﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Kosanovic, D
   Tian, X
   Pak, O
   Lai, YJ
   Hsieh, YL
   Seimetz, M
   Weissmann, N
   Schermuly, RT
   Dahal, BK
AF Kosanovic, Djuro
   Tian, Xia
   Pak, Oleg
   Lai, Ying-Ju
   Hsieh, Yi-Ling
   Seimetz, Michael
   Weissmann, Norbert
   Schermuly, Ralph Theo
   Dahal, Bhola Kumar
TI Rhodiola: an ordinary plant or a promising future therapy for
   pulmonary hypertension? a brief review
SO PULMONARY CIRCULATION
LA English
DT Review
DE Rhodiola; pulmonary hypertension; pulmonary vascular remodeling; Chinese
   medicine; salidroside
ID ARTERIAL-HYPERTENSION; PHENOLIC-COMPOUNDS; REACTIVE OXYGEN; ANTIOXIDANT;
   EXPRESSION; MANAGEMENT; INHIBITOR; ROSEA
AB Pulmonary hypertension (PH) is a chronic, complex, and progressive disease that eventuates in fatality. Research efforts over the past decades have resulted in therapeutic options that improve quality of life and prolong survival of patients, but they do not offer a cure. We propose a philosophical model that a disturbed balance of yin and yang results in pulmonary vascular remodeling, the hallmark of PH pathology. The model may be useful in exploring the wisdom of traditional Chinese medicine and incorporating it into mainstream PH research. In this context, the medicinal plant Rhodiola can be of profound interest owing to its variety of health-friendly attributes. Rhodiola has been shown to be beneficial in high-altitude-related symptoms and acute exacerbation of PH; moreover, improvement of PH has been demonstrated experimentally in chronically hypoxic rats. The beneficial effects of Rhodiola in PH may be attributable to its potential targeting of the signaling pathways, such as endothelin-1, nitric oxide, vascular endothelial growth factor, angiotensin-converting enzyme, nuclear factor kappa-B, tumor necrosis factor alpha, and interleukin-6. Alterations in these mediators are implicated in PH pathogenesis, the characteristics of which include chronic pulmonary vasoconstriction, vasoproliferation, and vascular inflammation. Salidroside, one of the compounds extracted from Rhodiola, has been found to provide therapeutic benefits in experimental PH. As the data are limited and the field is in its infancy, further studies including in-depth analysis of the therapeutic effects on various animal models of PH are desirable. We believe that future PH research should place an adequate and special emphasis on exploring and promoting the potential of traditional Chinese medicine, and to this end, the medicinal plant Rhodiola offers a promising field on which to embark.
C1 [Kosanovic, Djuro; Tian, Xia; Pak, Oleg; Seimetz, Michael; Weissmann, Norbert; Schermuly, Ralph Theo; Dahal, Bhola Kumar] Univ Giessen & Marburg Lung Ctr, Dept Internal Med, Giessen, Germany.
   [Lai, Ying-Ju] Chang Gung Univ, Coll Med, Dept Resp Therapy, Taoyuan, Taiwan.
   [Hsieh, Yi-Ling] Chang Gung Univ, Coll Med, Grad Inst Clin Med Sci, Taoyuan, Taiwan.
C3 Chang Gung University; Chang Gung University
RP Schermuly, RT (corresponding author), Univ Giessen & Marburg Lung Ctr, Justus Liebig Univ Aulweg 130, D-35392 Giessen, Germany.
EM ralph.schermuly@innere.med.uni-giessen.de
RI Kosanovic, Djuro/AAQ-7510-2021
OI Kosanovic, Djuro/0000-0002-7094-2269; Weissmann,
   Norbert/0000-0003-2675-3871; Hsieh, Yi-Ling/0000-0002-7929-5213;
   Schermuly, Ralph/0000-0002-5167-6970; Lai, Ying-Ju/0000-0001-9750-7649
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NR 47
TC 29
Z9 34
U1 1
U2 14
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 2045-8932
EI 2045-8940
J9 PULM CIRC
JI Pulm. Circ.
PD SEP
PY 2013
VL 3
IS 3
BP 499
EP 506
DI 10.1086/674303
PG 8
WC Cardiac & Cardiovascular Systems; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System
GA V47WJ
UT WOS:000209981600005
PM 24618536
OA Bronze
DA 2026-05-27
ER

PT J
AU Chen, X
   Deng, AQ
   Zhou, TQ
   Ding, F
AF Chen, Xia
   Deng, Aiqing
   Zhou, Tianqiu
   Ding, Fei
TI Pretreatment with
   2-(4-Methoxyphenyl)ethyl-2-acetamido-2-deoxy-β-D-pyranoside Attenuates
   Cerebral Ischemia/Reperfusion-Induced Injury In Vitro and In
   Vivo
SO PLOS ONE
LA English
DT Article
ID ISCHEMIC BRAIN-INJURY; CULTURED HIPPOCAMPAL-NEURONS; INDUCED OXIDATIVE
   STRESS; NITRIC-OXIDE SYNTHASE; BCL-2 FAMILY PROTEINS; GLUCOSE
   DEPRIVATION; REPERFUSION INJURY; CORTICAL-NEURONS; CELL-DEATH; COGNITIVE
   IMPAIRMENT
AB Salidroside, extracted from the root of Rhodiola rosea L, is known for its pharmacological properties, in particular its neuroprotective effects. 2-(4-Methoxyphenyl) ethyl-2-acetamido-2-deoxy-beta-D- pyranoside (GlcNAc-Sal), an analog of salidroside, was recently synthesized and shown to possess neuroprotective properties. The purpose of the current study was to investigate the neuroprotective effects of GlcNAc-Sal against oxygen-glucose deprivation-reperfusion (OGD-R)-induced neurotoxicity in vitro and global cerebral ischemia-reperfusion (GCI-R) injury in vivo. Cell viability tests and Hoechst 33342 staining confirmed that GlcNAc-Sal pretreatment markedly attenuated OGD-R induced apoptotic cell death in immortalized mouse hippocampal HT22 cells. Western blot, immunofluorescence and PCR analyses revealed that GlcNAc-Sal pretreatment restored the balance of pro-and anti-apoptotic proteins and inhibited the activation of caspase-3 and PARP induced by OGD-R treatment. Further analyses showed that GlcNAc-Sal pretreatment antagonized reactive oxygen species (ROS) generation, iNOS-derived NO production and NO-related apoptotic cell death during OGD-R stimulation. GCI-R was induced by bilateral common carotid artery occlusion (BCCAO) and reperfusion in mice in vivo. Western blot analysis showed that GlcNAc-Sal pretreatment decreased the expression of caspase-3 and increased the expression of Bcl-2 (B-cell lymphoma 2)/Bax (Bcl-2-associated X protein) induced by GCI-R treatment. Our findings suggest that GlcNAc-Sal pretreatment prevents brain ischemia reperfusion injury by the direct or indirect suppression of cell apoptosis and GlcNAc-Sal could be developed as a broad-spectrum agent for the prevention and/or treatment of cerebral ischemic injury.
C1 [Chen, Xia] Nantong Univ, Basic Med Res Ctr, Sch Med, Nantong, Peoples R China.
   [Deng, Aiqing] Nantong Univ, Affiliated Hosp, Dept Pharm, Nantong, Peoples R China.
   [Zhou, Tianqiu] Nantong Univ, Affiliated Hosp, Dept Ophthalmol, Nantong, Peoples R China.
   [Ding, Fei] Nantong Univ, Jiangsu Key Lab Neuroregenerat, Nantong, Peoples R China.
C3 Nantong University; Nantong University; Nantong University; Nantong
   University
RP Ding, F (corresponding author), Nantong Univ, Jiangsu Key Lab Neuroregenerat, Nantong, Peoples R China.
EM dingfei@ntu.edu.cn
RI DING, FEI/KLD-8925-2024
FU Natural Science Foundation of the Jiangsu Higher Education Institutions
   of China [12KJD310002]; Priority Academic Program Development of Jiangsu
   Higher Education Institutions (PAPD)
FX Project supported by the Natural Science Foundation of the Jiangsu
   Higher Education Institutions of China (Grant No. 12KJD310002) and the
   Priority Academic Program Development of Jiangsu Higher Education
   Institutions (PAPD). The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 63
TC 15
Z9 18
U1 0
U2 15
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 3
PY 2014
VL 9
IS 7
AR e100126
DI 10.1371/journal.pone.0100126
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AO3RT
UT WOS:000341253400018
PM 24991917
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhang, P
   Zhao, HX
   Xia, XP
   Xiao, H
   Han, C
   You, ZB
   Wang, JJ
   Cao, F
AF Zhang, Peng
   Zhao, Hongxin
   Xia, Xiangping
   Xiao, Hua
   Han, Chong
   You, Zhibo
   Wang, Junjie
   Cao, Fang
TI Network pharmacology and molecular-docking-based strategy to explore the
   potential mechanism of salidroside-inhibited oxidative stress in retinal
   ganglion cell
SO PLOS ONE
LA English
DT Article
ID MITOCHONDRIA
AB Background Salidroside (SAL), the main component of Rhodiola rosea extract, is a flavonoid with biological activities, such as antioxidative stress, anti-inflammatory, and hypolipidemic. In this study, the potential therapeutic targets and mechanisms of SAL against oxidative stress in retinal ganglion cells (RGCs) were investigated on the basis of in-vitro experiments, network pharmacology, and molecular docking techniques.Methods RGC oxidative stress models were constructed, and cell activity, reactive oxygen species (ROS), and apoptosis levels were examined for differences. The genes corresponding to rhodopsin, RGCs, and oxidative stress were screened from GeneCards, TCMSP database, and an analysis platform. The intersection of the three was taken, and a Venn diagram was drawn. Protein interactions, GO functional enrichment, and KEGG pathway enrichment data were analyzed by STRING database, Cytohubba plugin, and Metascape database. The key factors in the screening pathway were validated using qRT-PCR. Finally, molecular docking prediction was performed using MOE 2019 software, molecular dynamic simulations was performed using Gromacs 2018 software.Results In the RGC oxidative stress model in vitro, the cell activity was enhanced, ROS was reduced, and apoptosis was decreased after SAL treatment. A total of 16 potential targets of oxidative stress in SAL RGCs were obtained, and the top 10 core targets were screened by network topology analysis. GO analysis showed that SAL retinal oxidative stress treatment mainly involved cellular response to stress, transcriptional regulatory complexes, and DNA-binding transcription factor binding. KEGG analysis showed that most genes were mainly enriched in multiple cancer pathways and signaling pathways in diabetic complications, nonalcoholic fatty liver, and lipid and atherosclerosis. Validation by PCR, molecular docking and molecular dynamic simulations revealed that SAL may attenuate oxidative stress and reduce apoptosis in RGCs by regulating SIRT1, NRF2, and NOS3.Conclusion This study initially revealed the antioxidant therapeutic effects and molecular mechanisms of SAL on RGCs, providing a theoretical basis for subsequent studies.
C1 [Zhang, Peng; Zhao, Hongxin; Xia, Xiangping; Xiao, Hua; Han, Chong; You, Zhibo; Wang, Junjie; Cao, Fang] Zunyi Med Univ, Affiliated Hosp, Dept Neurosurg, Zunyi, Guizhou, Peoples R China.
C3 Zunyi Medical University
RP Cao, F (corresponding author), Zunyi Med Univ, Affiliated Hosp, Dept Neurosurg, Zunyi, Guizhou, Peoples R China.
EM caof@zmu.edu.cn
RI Zhang, Peng/KEH-1065-2024
OI Wang, Junjie/0009-0007-9978-9345
FU Guizhou Provincial Department of Science and Technology [ZK[2021]YB473]]
FX P.Z. has received funding from Guizhou Provincial Department of Science
   and Technology, through the Science and Technology Program of Guizhou
   Province (ZK[2021]YB473]). The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 35
TC 9
Z9 10
U1 1
U2 15
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 5
PY 2024
VL 19
IS 7
AR e0305343
DI 10.1371/journal.pone.0305343
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA XX2C1
UT WOS:001264900000050
PM 38968273
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Ke, Z
   Ting, L
   Xing-Cheng, G
   Li-Bo, C
   Jun, L
   Peng-Fei, T
   Qing-Qing, S
   Yue-Lin, S
AF Ke, Zhang
   Ting, Li
   Xing-Cheng, Gong
   Li-Bo, Cao
   Jun, Li
   Peng-Fei, Tu
   Qing-Qing, Song
   Yue-Lin, Song
TI Online energy-resolved MS boosts the potential of LC-MS towards
   metabolite characterization of salidroside and tyrosol
SO ANALYTICAL METHODS
LA English
DT Article
ID MASS-SPECTROMETRY; IN-VITRO; SAPONINS; BEHAVIOR; PROFILE; RATS
AB Although currently serving as the workhorse for metabolite characterization, one of the most challenging tasks for LC-MS is isomeric differentiation because isomers frequently yield identical quasi-molecular ions and fragmented ion species. Our previous studies have demonstrated that online energy-resolved MS (ER-MS) is an orthogonal technique for MS/MS experiments to facilitate isomeric identification. Herein, attempts were made for the in-depth characterization of the metabolic profiles of an effective natural product named salidroside (SA) in rats using LC coupled with three-dimensional mass spectrometry (LC-3D MS) that was configured by MS1, MS2 and online ER-MS as 1(st), 2(nd), and 3(rd) dimensions, respectively. Moreover, the metabolism characterization of its aglycone, namely, tyrosol (Try) was conducted in parallel to aid in proposing metabolic pathways. High-resolution MS1 and MS2 spectra were acquired by IT-TOF-MS, and subsequent data processing provided theoretical formula and sub-structures for each metabolite. Subsequently, online ER-MS was conducted for precursor > product ion transitions-of-interest to offer linkage information among the sub-structures via building breakdown graphs. As a result, ten (M1-10) and nine (M1, M2, and M5-11) metabolites were detected in SA- and Tyr-administrated biological samples, respectively, and their structures were qualitatively identified. Crucial metabolism occurred for either component. SA initially underwent hydrolysis to produce Tyr, and subsequently hydroxylation, oxidation, glucuronidation, and sulfation were observed as the primary metabolic pathways. To summarize, the metabolic fate of SA was understood in depth, and Tyr, as the hydrolytic product, was responsible for the occurrences of most metabolites (M1, M2, and M5-10). More importantly, identification confidences of the metabolites were significantly advanced by LC-3D MS, suggesting that it is eligible to serve as an integral part of the analyst's toolbox.
C1 [Ke, Zhang; Ting, Li; Xing-Cheng, Gong; Li-Bo, Cao; Jun, Li; Peng-Fei, Tu; Qing-Qing, Song; Yue-Lin, Song] Univ Chinese Med, Sch Chinese Mat Med, Beijing 100029, Peoples R China.
RP Yue-Lin, S (corresponding author), Univ Chinese Med, Sch Chinese Mat Med, Beijing 100029, Peoples R China.
EM song_qingq@bucm.edu.cn
RI Song, Yuelin/J-6508-2014; Li, Jun/M-9884-2016
OI Song, Yuelin/0000-0001-9431-6257; 
FU National Key Research and Development Project [2018YFC1707300]; National
   Natural Science Foundation of China [81773875, 81973444, 82003911];
   Young Scientist Program by Beijing University of Chinese Medicine
   [BUCM-2019QNKXJB006]
FX This work was financially supported by the National Key Research and
   Development Project (2018YFC1707300), the National Natural Science
   Foundation of China (81773875, 81973444 and 82003911), and the Young
   Scientist Program by Beijing University of Chinese Medicine
   (BUCM-2019QNKXJB006).
CR Argikar UA, 2012, DRUG METAB DISPOS, V40, P1239, DOI 10.1124/dmd.112.045096
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NR 23
TC 8
Z9 9
U1 0
U2 30
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 1759-9660
EI 1759-9679
J9 ANAL METHODS-UK
JI Anal. Methods
PD NOV 14
PY 2020
VL 12
IS 42
BP 5120
EP 5127
DI 10.1039/d0ay01639j
PG 8
WC Chemistry, Analytical; Food Science & Technology; Spectroscopy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Food Science & Technology; Spectroscopy
GA OM6CZ
UT WOS:000586111600010
PM 33057462
DA 2026-05-27
ER

PT J
AU Yan, W
   Li, K
   Buhe, A
   Li, TX
   Tian, PR
   Hong, J
AF Yan, Wei
   Li, Kai
   Buhe, Amin
   Li, Tianxiong
   Tian, Peirong
   Hong, Jun
TI RETRACTED: Salidroside inhibits the proliferation and migration of
   gastric carcinoma cells and tumor growth via the activation of
   ERS-dependent autophagy and apoptosis (Retracted Article)
SO RSC ADVANCES
LA English
DT Article; Retracted Publication
ID CANCER CELLS; EXPRESSION; INVASION; PATHWAY
AB The endoplasmic reticulum stress (ERS)-induced autophagy and apoptosis are favorable for the suppression of many cancer types. Salidroside (Salid) has been proven to be capable of inducing the apoptosis of many cancer cells. However, the underlying mechanisms and whether Salid can activate the autophagic system have still not been explained thoroughly. Herein, the inhibition effect of Salid on the growth and progress of gastric cancer and the underlying mechanisms were investigated. With the SGC-7901 cells acting as the cancer model cells, we ascertained that Salid exerted a superior antagonism effect on the growth and migration of gastric cancer cells in a dose-dependent manner. Additionally, Salid exhibited strong capacity to induce cell apoptosis by the down-regulation of proliferation-related genes (Ki67 and PCNA), increase in the pro-apoptotic protein C-caspase-3, and changing the levels of other related genes. A mechanism study revealed that the levels of the ERS-related genes, such as CHOP, C-caspase-12, GADD34, and BiP, in the SGC-7901 cells dramatically changed post-treatment by Salid, indicating the involvement of ERS in Salid-inducing cell apoptosis. In addition, the increased LC3(+) autophagic vacuoles, enhanced conversion of LC3-I to LC3-II, and inhibition of the PI3K/Akt/mTOR pathway further confirmed the activation of autophagy induced by Salid. Importantly, the effect of Salid in regulating the levels of autophagy-related proteins or the signaling pathway could be markedly depressed by co-incubating with Wortmannin (Wort), an autophagy inhibitor. The final evaluation of the tumor therapy efficacy exhibited satisfactory cancer growth inhibition by Salid with negligible toxicity to normal tissues. In summary, the present work provides a comprehensive effective evaluation of Salid for treating gastric cancer. The detailed investigation of the underlying mechanisms may offer a rational reference for the future applications of Salid in clinic.
C1 [Yan, Wei; Li, Kai; Buhe, Amin; Li, Tianxiong; Tian, Peirong] Capital Med Univ, Beijing Shijitan Hosp, Dept Gen Surg, Beijing, Peoples R China.
   [Hong, Jun] Vanderbilt Univ, Dept Surg, Med Ctr, Nashville, TN 37240 USA.
C3 Capital Medical University; Vanderbilt University
RP Yan, W (corresponding author), Capital Med Univ, Beijing Shijitan Hosp, Dept Gen Surg, Beijing, Peoples R China.
EM wei_yan1@aliyun.com
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NR 40
TC 8
Z9 9
U1 0
U2 8
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
EI 2046-2069
J9 RSC ADV
JI RSC Adv.
PD AUG 18
PY 2019
VL 9
IS 44
BP 25655
EP 25666
DI 10.1039/c9ra00044e
PG 12
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA IS0YP
UT WOS:000481879400039
PM 35530072
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Mudge, E
   Lopes-Lutz, D
   Brown, PN
   Schieber, A
AF Mudge, Elizabeth
   Lopes-Lutz, Daise
   Brown, Paula N.
   Schieber, Andreas
TI Purification of Phenylalkanoids and Monoterpene Glycosides from
   Rhodiola rosea L. Roots by High-speed Counter-current
   Chromatography
SO PHYTOCHEMICAL ANALYSIS
LA English
DT Article
DE HSCCC; phenylalkanoids; Rhodiola rosea L.
ID STANDARDIZED EXTRACT SHR-5; DOUBLE-BLIND; LIQUID-CHROMATOGRAPHY;
   UNDERGROUND PART; PLACEBO; STRESS; SALIDROSIDE; PERFORMANCE; FATIGUE;
   TRIAL
AB Introduction - Rhodiola rosea L. is a medicinal herb used for its adaptogenic properties. The main active components are the phenylpropanoids collectively referred to as rosavins.
   Objectives - To develop an isolation method for phytochemicals present in Rhodiola rosea roots using high-speed countercurrent chromatography (HSCCC).
   Methodology - The roots of Rhodiola rosea were extracted with methanol and fractionated using liquid-liquid partition and polyamide column clean-up. The purified fraction (100 mg) was subjected to semi-preparative HSCCC using the two-phase solvent system ethyl acetate: butanol: water (3: 2: 5). The head-to-tail elution mode was employed with a flow rate of 1.5 mL/min and a rotary speed of 1000 rpm.
   Results - The separation yielded six main fractions with four components more than 90% pure. The sixth fraction was further purified using semi-preparative HPLC with a Synergi-hydro RP C-18-column to obtain rosin and geranyl 1-O-alpha-L-arabinopyranosyl (1 -> 6)-beta-D-glucopyranoside. The main components isolated were rosavin (3.4 mg, 97% purity), salidroside (0.5 mg, 90% purity), benzyl-O-beta-D-glucopyranoside (1.2 mg, 85% purity), rosarin (1.3 mg, 99% purity), rosiridin (1.8 mg, 92% purity), rosin (1.2 mg, 95% purity) and geranyl 1-O-alpha-L-arabinopyranosyl(1 -> 6)-beta-D-glucopyranoside (6.5 mg, 97% purity). The identity and purity of these components were confirmed using ultrafast liquid chromatography-diode-array detector-MS/MS analysis, 1 H-and C-13-NMR spectroscopy.
   Conclusion - High-speed counter-current chromatography was successful in the isolation of several phytochemicals present in Rhodiola rosea roots, including two components that are not commercially available. Copyright (C) 2012 John Wiley & Sons, Ltd.
C1 [Mudge, Elizabeth; Lopes-Lutz, Daise; Schieber, Andreas] Univ Alberta, Dept Agr Food & Nutr Sci, Agr Forestry Ctr 4 10, Edmonton, AB T6G 2P5, Canada.
   [Mudge, Elizabeth; Brown, Paula N.] British Columbia Inst Technol, Burnaby, BC V5G 3H2, Canada.
   [Schieber, Andreas] Univ Bonn, Inst Nutr & Food Sci, D-53117 Bonn, Germany.
C3 University of Alberta; British Columbia Institute of Technology;
   University of Bonn
RP Schieber, A (corresponding author), Univ Bonn, Inst Nutr & Food Sci, Romerstr 164, D-53117 Bonn, Germany.
EM Schieber@uni-bonn.de
OI Mudge, Elizabeth M/0000-0003-2266-5639; Schieber,
   Andreas/0000-0002-1082-9547
FU Alberta Innovates-BioSolutions [ALSI-09-G19]; Advanced Foods and
   Materials Network; Canada Research Chairs programme
FX We gratefully acknowledge financial support from Alberta
   Innovates-BioSolutions (Project ALSI-09-G19) and the Advanced Foods and
   Materials Network. This research was undertaken, in part, thanks to
   funding from the Canada Research Chairs programme.
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NR 32
TC 27
Z9 30
U1 0
U2 88
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0958-0344
EI 1099-1565
J9 PHYTOCHEM ANALYSIS
JI Phytochem. Anal.
PY 2013
VL 24
IS 2
BP 129
EP 134
DI 10.1002/pca.2391
PG 6
WC Biochemical Research Methods; Plant Sciences; Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Plant Sciences; Chemistry
GA 131OI
UT WOS:000318002600005
PM 22811209
DA 2026-05-27
ER

PT J
AU Choo, HJ
   Kim, EJ
   Kim, SY
   Lee, Y
   Kim, BG
   Ahn, JH
AF Choo, Hye Jeong
   Kim, Eun Ji
   Kim, So Yeon
   Lee, Youngshim
   Kim, Bong-Gyu
   Ahn, Joong-Hoon
TI Microbial synthesis of hydroxytyrosol and hydroxysalidroside
SO APPLIED BIOLOGICAL CHEMISTRY
LA English
DT Article
DE Hydroxysalidroside; Hydroxytyrosol; Metabolic engineering
ID ESCHERICHIA-COLI; ARABIDOPSIS-THALIANA; BIOSYNTHESIS; OXIDATION;
   GLYCOSIDE
AB Plant-derived phenolic compounds, such as hydroxytyrosol and hydroxysalidroside, have a beneficial impact on human health owing to their antioxidant activity. In this study, we used Escherichia coli to synthesize hydroxytyrosol. Tyrosine decarboxylase from Papaver somniferum, tyrosine oxidase from Micrococcus luteus, and 4-hydroxyphenylacetate 3-monooxygenase from E. coli were transformed into the bacterial cell. The resulting transformant successfully synthesized hydroxytyrosol. Furthermore, we used the engineered E. coli strains to synthesize similar to 268.3 mg/L hydroxytyrosol. Three uridine diphosphate-dependent glycosyltransferases (UGTs), which were previously shown to convert tyrosol into salidroside, were tested to synthesize hydroxysalidroside, and one of UGTs was used to synthesize hydroxysalidroside from hydroxytyrosol. Finally, E. coli harboring this UGT converted approximately 50% of hydroxytyrosol into hydroxysalidroside.
C1 [Choo, Hye Jeong; Kim, Eun Ji; Kim, So Yeon; Lee, Youngshim; Ahn, Joong-Hoon] Konkuk Univ, Biomol Informat Ctr, Dept Integrat Biosci & Biotechnol, Seoul 05029, South Korea.
   [Kim, Bong-Gyu] Gyeongnam Natl Univ Sci & Technol, Dept Forest Resources, 33 Dongjin Ro, Jinju Si 52725, Gyeongsangnam D, South Korea.
C3 Konkuk University; Gyeongnam National University of Science and
   Technology
RP Ahn, JH (corresponding author), Konkuk Univ, Biomol Informat Ctr, Dept Integrat Biosci & Biotechnol, Seoul 05029, South Korea.
EM jhahn@konkuk.ac.kr
FU Next-Generation BioGreen 21 Program through the National Research
   Foundation of Korea - Ministry of Education, Science, and Technology
   [PJ01326001]; Rural Development Administration through the National
   Research Foundation of Korea - Ministry of Education, Science, and
   Technology; Priority Research Centers Program through the National
   Research Foundation of Korea - Ministry of Education, Science, and
   Technology [2009-0093824]
FX This work was supported by a grant from the Next-Generation BioGreen 21
   Program (PJ01326001), Rural Development Administration, and Priority
   Research Centers Program through the National Research Foundation of
   Korea funded by the Ministry of Education, Science, and Technology
   (2009-0093824).
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NR 25
TC 32
Z9 41
U1 3
U2 117
PU KOREAN SOC  APPLIED BIOLOGICAL CHEMISTRY
PI KANGNAM-GU
PA RM 803,  KOREA SCIENCE & TECHNOLOGY CENTER, 635-4 YEOGSAM-DONG,
   KANGNAM-GU, SEOUL 135-703, SOUTH KOREA
SN 2468-0834
EI 2468-0842
J9 APPL BIOL CHEM
JI Appl. Biol. Chem.
PD JUN
PY 2018
VL 61
IS 3
BP 295
EP 301
DI 10.1007/s13765-018-0360-x
PG 7
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA GJ0CV
UT WOS:000434915700006
OA gold
DA 2026-05-27
ER

PT J
AU Feng, C
   Zheng, W
   Han, L
   Wang, JK
   Zha, XP
   Xiao, Q
   He, ZJ
   Kang, JC
AF Feng, Can
   Zheng, Wen
   Han, Long
   Wang, Jian-kang
   Zha, Xing-ping
   Xiao, Qing
   He, Zhang-jiang
   Kang, Ji-chuan
TI AaLaeA targets AaFla1 to mediate the production of antitumor compound in
   Alternaria alstroemeria
SO JOURNAL OF BASIC MICROBIOLOGY
LA English
DT Article
DE Alternaria alstroemeria; antitumor substances; FAD-binding domain
   protein; global regulator AaLaeA; metabolomics
ID CANCER; EXPRESSION; LAEA; FLAVOENZYMES; REGULATOR; APOPTOSIS; PACKAGE;
   GROWTH; DAMAGE
AB Endophytic fungi are an important source of novel antitumor substances. Previously, we isolated an endophytic fungus, Alternaria alstroemeria, from the medicinal plant Artemisia artemisia, whose crude extracts strongly inhibited A549 tumor cells. We obtained a transformant, namely AaLaeA(OE26), which completely loses its antitumor activity due to overexpression of the global regulator AaLaeA. Re-sequencing analysis of the genome revealed that the insertion site was in the noncoding region and did not destroy any other genes. Metabolomics analysis revealed that the level of secondary antitumor metabolic substances was significantly lower in AaLaeA(OE26) compared with the wild strain, in particular flavonoids were more downregulated according to the metabolomics analysis. A further comparative transcriptome analysis revealed that a gene encoding FAD-binding domain protein (Fla1) was significantly downregulated. On the other hand, overexpression of AaFla1 led to significant enhancement of antitumor activity against A549 with a sevenfold higher inhibition ratio than the wild strain. At the same time, we also found a significant increase in the accumulation of antitumor metabolites including quercetin, gitogenin, rhodioloside, liensinine, ginsenoside Rg2 and cinobufagin. Our data suggest that the global regulator AaLaeA negatively affects the production of antitumor compounds via controlling the transcription of AaFla1 in endophytic A. alstroemeria.
C1 [Feng, Can; He, Zhang-jiang; Kang, Ji-chuan] Guizhou Univ, Coll Pharm, Guiyang 550025, Peoples R China.
   [Feng, Can; Zheng, Wen; Han, Long; Wang, Jian-kang; Zha, Xing-ping; Xiao, Qing; He, Zhang-jiang; Kang, Ji-chuan] Guizhou Univ, Minist Educ, Southwest Biomed Resources, Guiyang, Peoples R China.
C3 Guizhou University; Guizhou University
RP He, ZJ; Kang, JC (corresponding author), Guizhou Univ, Coll Pharm, Guiyang 550025, Peoples R China.
EM zjhe3@gzu.edu.cn; jckang@gzu.edu.cn
FU National Natural Science Foundation of China [32160667, 31901947,
   32170019]; Guizhou University Incubation [[2019] 19];  [Qian Kehe-ZK
   [2021]-145];  [Gui Da Ren Ji He Zi (2019) 71]
FX National Natural Science Foundation of China, Grant/Award Numbers:
   32160667, 31901947, 32170019; Qian Kehe-ZK [2021]-145; Gui Da Ren Ji He
   Zi (2019) 71; Guizhou University Incubation [2019] 19
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NR 46
TC 4
Z9 4
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0233-111X
EI 1521-4028
J9 J BASIC MICROB
JI J. Basic Microbiol.
PD JAN
PY 2024
VL 64
IS 1
SI SI
BP 68
EP 80
DI 10.1002/jobm.202300319
EA SEP 2023
PG 13
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA EL0V3
UT WOS:001067821500001
PM 37717245
DA 2026-05-27
ER

PT J
AU Jensen, SR
   Opitz, SEW
   Gotfredsen, CH
AF Jensen, Soren Rosendal
   Opitz, Sebastian Ed Wieland
   Gotfredsen, Charlotte Held
TI A new phenylethanoid triglycoside in Veronica beccabunga L
SO BIOCHEMICAL SYSTEMATICS AND ECOLOGY
LA English
DT Article
DE Veronica beccabunga; Plantaginaceae; Mannitol; Iridoid glucoside;
   Phenylethanoid glycoside; Chionoside J
ID IRIDOID GLUCOSIDES; GLYCOSIDES; CHEMOTAXONOMY; MARKERS
AB Besides the expected iridoid glucosides aucubin and catalpol as well as three known esters of the latter, Veronica beccabunga (brooklime) was shown to contain five carboxylated iridoid glucosides, namely gardoside, mussaenosidic acid, 8-epiloganic acid, arborescosidic acid and alpinoside. In addition to these compounds, the plant contained salidroside and a previously unknown caffeoyl phenylethanoid glycoside (CPG) which we have named chionoside J. The structure was elucidated mainly by 1D and 2D NMR spectroscopy to be 2 ''-(beta-glucopyranosyl)-plantamajoside. The distribution of plantamajoside and its derivatives as well as that of carbocyclic iridoids with an 8,9-double bond is briefly discussed, and it is noted that such compounds are mainly confined to the tribe Veroniceae of the Plantaginaceae. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Jensen, Soren Rosendal; Gotfredsen, Charlotte Held] Tech Univ Denmark, Dept Chem, DK-2800 Lyngby, Denmark.
   [Opitz, Sebastian Ed Wieland] Univ Bielefeld, Dept Chem Ecol, D-33615 Bielefeld, Germany.
C3 Technical University of Denmark; University of Bielefeld
RP Jensen, SR (corresponding author), Tech Univ Denmark, Dept Chem, DK-2800 Lyngby, Denmark.
EM srj@kemi.dtu.dk
RI ; Gotfredsen, Charlotte Held/ABC-8211-2021; Opitz, Sebastian Ed
   Wieland/AFK-4118-2022
OI Jensen, Soren/0000-0003-4573-9282; Gotfredsen, Charlotte
   Held/0000-0002-7386-119X; 
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NR 24
TC 16
Z9 16
U1 0
U2 29
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0305-1978
EI 1873-2925
J9 BIOCHEM SYST ECOL
JI Biochem. Syst. Ecol.
PD JUN
PY 2011
VL 39
IS 3
BP 193
EP 197
DI 10.1016/j.bse.2011.02.008
PG 5
WC Biochemistry & Molecular Biology; Ecology; Evolutionary Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Environmental Sciences & Ecology;
   Evolutionary Biology
GA 781AL
UT WOS:000291902900004
DA 2026-05-27
ER

PT J
AU Zheng, LZ
   Su, JM
   Zhang, ZY
   Jiang, L
   Wei, JL
   Xu, XY
   Lv, SM
AF Zheng, Lanzhi
   Su, Jianming
   Zhang, Zhuoyi
   Jiang, Lu
   Wei, Jinling
   Xu, Xiaoyang
   Lv, Shumin
TI Salidroside regulates inflammatory pathway of alveolar macrophages by
   influencing the secretion of miRNA-146a exosomes by lung epithelial
   cells
SO SCIENTIFIC REPORTS
LA English
DT Article
ID RESPONSES; INJURY
AB The purpose of this study was to explore the investigative mechanism of salidroside (SAL) on LPS-induced acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). The exosomes from RLE-6TN are extracted and identified by transmission electron microscopy, particle size analysis and protein marker detection, and co-cultured with NR8383 cells. The ALI/ARDS model of SD rats was established by LPS (10 mg/kg) intratracheal instillation. Following a four-hour intratracheal instillation of LPS, 50 mu l of RLE-6TN exosomes were injected through the tail vein. After that, SAL and miR-146a antagomir were injected into the tail vein for 72 h, respectively. As the changes of HE stain, body weight and ALI score are observed. The expression of miR-146a, TLR4, NF-kB, IRAK1, TRAF6 and their related proteins were detected by RT-PCR and Western blot, respectively. TNF-alpha, IL-6, IL-8 and IL-1 beta inflammatory factors were detected by ELISA. The expression of miR-146a, NF-kB, IRAK, TRAF6 and related inflammatory factors in LPS-induced NR8383 was significantly higher than that in the control group, while SAL has greatly reduced the expression of TLR4 mediated NF-kB inflammatory pathway and related inflammatory factors. SAL can significantly improve the LPS-induced lung morphological abnormalities, slowed down the rate of weight loss in rats, and reducing the ALI score. The expression trend of NF-kB, IRAK, TRAF6 and related inflammatory factors in rats' lung tissues was consistent with that in NR8383 cells. SAL has a protective effect on ALI/ARDS caused by sepsis, which is likely to be developed to a potential treatment for the disease. To sum up, this study provides a new theoretical basis for the treatment of ALI/ARDS with SAL.
C1 [Zheng, Lanzhi; Su, Jianming; Zhang, Zhuoyi; Jiang, Lu; Wei, Jinling; Xu, Xiaoyang] Zhejiang Chinese Med Univ, Emergency Dept, Affiliated Hosp 1, Hangzhou 310006, Zhejiang, Peoples R China.
   [Lv, Shumin] Zhejiang Chinese Med Univ, Dept Cardiol, Affiliated Hosp 1, Hangzhou 310006, Zhejiang, Peoples R China.
C3 Zhejiang Chinese Medical University; Zhejiang Chinese Medical University
RP Lv, SM (corresponding author), Zhejiang Chinese Med Univ, Dept Cardiol, Affiliated Hosp 1, Hangzhou 310006, Zhejiang, Peoples R China.
EM ShuminLv666@126.com
FU project of science and technology plan of traditional Chinese medicine
   in Zhejiang Province [2019ZB035]
FX This work was supported by the project of science and technology plan of
   traditional Chinese medicine in Zhejiang Province (Grant no. 2019ZB035).
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NR 25
TC 32
Z9 40
U1 1
U2 17
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD DEC 27
PY 2020
VL 10
IS 1
AR 20750
DI 10.1038/s41598-020-77448-6
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA PB4QU
UT WOS:000596308000008
PM 33247202
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Borgonetti, V
   Governa, P
   Biagi, M
   Dalia, P
   Corsi, L
AF Borgonetti, Vittoria
   Governa, Paolo
   Biagi, Marco
   Dalia, Pasquale
   Corsi, Lorenzo
TI Rhodiola rosea L. modulates inflammatory processes in a
   CRH-activated BV2 cell model
SO PHYTOMEDICINE
LA English
DT Article
DE Rhodiola rosea L.; microglia; CRH; HSP70; MAPK; NF-kappa B
ID MOLECULAR-MECHANISMS; SIGNAL-TRANSDUCTION; STRESS; SALIDROSIDE;
   ADAPTOGENS; EXTRACT; SUPPRESSES
AB Background: Rhodiola rosea L. (Crassulaceae) has been used for years in the traditional medicine of several countries as an adaptogen drug, able to preserve homeostasis in response to stress stimuli. Currently R. rosea roots and rhizome are classified as a traditional herbal medicinal product for temporary relief of symptoms of stress, such as fatigue and sensation of weakness by the European Medicines Agency.
   Hypothesis/Purpose: Increasing evidences suggest the involvement of neuroinflammation in response to stress. However, whether the modulation of neuroinflammatory parameters could be involved in the anti-stress effect of R. rosea has been barely studied. Thus, the aim of this work is to investigate the possible modulation of molecular inflammatory processes elicited by a R. rosea roots and rhizome ethanolic extract in an in vitro model of corticotropin releasing hormone (CRH)-stimulated BV2 microglial cells.
   Methods: BV2 cells were stimulated with CRH 100 nM and changes in cell viability, cytokines production and heat shock protein 70 (HSP70) levels were evaluated. Intracellular pathways related to inflammation, such as nuclear factor kappa-light-chain enhancer of activated B cells (NF-kappa B) nuclear translocation and mitogen-activated protein kinases (MAPK) activation were also analyzed.
   Results: We found that R. rosea extract (2.7% m/m rosavin and 1% m/m salidroside) 20 mu g/ml was able to counteract the neuroinflammatory effect of CRH by inhibiting NF-kappa B nuclear translocation with a mechanism of action involving the modulation of mitogen-activated protein kinase-activated protein kinase 2 (MKK2), extracellular signal-regulated kinase 1/2 (ERK 1/2) and c-Jun n-terminal kinase (JNK), resulting in a reduction of HSP70 expression.
   Conclusion: This work expands the knowledge of the intracellular mechanisms involved in R. rosea anti-stress activity and may be useful for the study of other adaptogen drugs.
C1 [Borgonetti, Vittoria] Univ Florence, Dept Neurosci Psychol Pharmacol & Child Hlth NEUR, Florence, Italy.
   [Governa, Paolo] Univ Siena, Dept Biotechnol Chem & Pharm, Dept Excellence 2018 2022, Siena, Italy.
   [Biagi, Marco] Univ Siena, Dept Phys Sci Earth & Environm, Str Laterina 8, I-53100 Siena, Italy.
   [Dalia, Pasquale; Corsi, Lorenzo] Univ Modena & Reggio Emilia, Dept Life Sci, Modena, Italy.
C3 University of Florence; University of Siena; University of Siena;
   Universita di Modena e Reggio Emilia
RP Biagi, M (corresponding author), Univ Siena, Dept Phys Sci Earth & Environm, Str Laterina 8, I-53100 Siena, Italy.
EM biagi4@unisi.it
RI Biagi, Marco/AAB-7660-2020; Governa, Paolo/I-6286-2019; Borgonetti,
   Vittoria/ABD-8135-2021; /D-2213-2015
OI Biagi, Marco/0000-0003-2997-4178; Governa, Paolo/0000-0002-5976-780X;
   Borgonetti, Vittoria/0000-0002-2203-5285; 
CR Ahmed T, 2016, BRAIN RES BULL, V125, P30, DOI 10.1016/j.brainresbull.2016.04.002
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NR 33
TC 31
Z9 39
U1 2
U2 21
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD MAR
PY 2020
VL 68
AR 153143
DI 10.1016/j.phymed.2019.153143
PG 7
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA LD2GA
UT WOS:000525848500005
PM 32018209
OA Green Submitted, Bronze
DA 2026-05-27
ER

PT J
AU Hou, Y
   Zhang, YT
   Jiang, SN
   Xie, N
   Zhang, Y
   Meng, XL
   Wang, XB
AF Hou, Ya
   Zhang, Yating
   Jiang, Shengnan
   Xie, Na
   Zhang, Yi
   Meng, Xianli
   Wang, Xiaobo
TI Salidroside intensifies mitochondrial function of
   CoCl2-damaged HT22 cells by stimulating PI3K-AKT-MAPK
   signaling pathway
SO PHYTOMEDICINE
LA English
DT Article
DE Salidroside; Hypoxia injury; HT22; Mitochondrial function; PI3K-AKT-MAPK
ID INJURY; HYPOXIA; APOPTOSIS; ISCHEMIA
AB Background: Salidroside (Sal), an active component from Rhodiola crenulata, has been confirmed to exert neu-roprotective effects against hypoxia. However, its molecular mechanisms of intensifying mitochondrial function still largely unknown. In the present study, we aimed to explore the mechanisms by which Sal heightened mitochondrial function in CoCl2-induced HT22 hypoxic injury.
   Methods: The hypoxic condition of HT22 cells was performed by CoCl2 stimulus. We then investigated the effects of Sal on the viability of hypoxic HT22 cells by cell counting kit-8. The contents of lactate dehydrogenase (LDH) release in cultured supernatant were detected by using commercial biochemical kit. Superoxide free radical scavenging activity, total antioxidant capacity assay kit with ferric reducing ability of plasma and 2,2 '-azino-bis (3-ethylbenzthiazoline-6-sulfonic acid) methods were employed to detect the free radical scavenging ability and antioxidant capacity of Sal. Meanwhile, intracellular reactive oxygen species (ROS), Ca2+ and mitochondrial membrane potential (MMP) were determined by corresponding specific labeled probes. Mitochondrial morphology was tested by Mito-tracker green with confocal microscopy. Hoechst 33342 and Annexin V-FITC/ propidium iodide staining were also employed to evaluate the effect of Sal on cell apoptosis. Oxygen con-sumption rate (OCR), real-time ATP production and proton efflux rate were measured using a Seahorse analyzer. Additionally, the potential interactions of Sal with PI3K-AKT signaling pathway-related proteins were predicted and tested by molecular docking, molecular dynamics simulation (MDS) and localized surface plasmon resonance (LSPR) techniques, respectively. Furthermore, the protein levels of p-PI3K, PI3K, p-AKT, AKT, p-JNK, JNK, p-p38 and p38 were estimated by western blot analysis.
   Results: Sal alleviated CoCl2-induced hypoxic injury in HT22 cells as evidenced by increased cell viability and decreased LDH release. In vitro antioxidant test confirmed that Sal had marvelous antioxidant abilities. The protected mitochondrial function by Sal treatment was illustrated by the decrease of ROS, Ca2+, mitochondrial fragment and the increase of MMP. In addition, Sal ameliorated the apoptosis of HT22 cells by decreasing Hoechst 33342 positive cells and the rate of apoptotic cells. Enhancement of energy metabolism in HT22 by Sal was demonstrated by increased OCR, real-time ATP generation and proton efflux rate. The molecular docking confirmed the potential binding of Sal to PI3K, AKT and CaMK II proteins with calculated binding energy of-1.32,-4.21 and-4.38 kcal/mol, respectively. The MDS test revealed the average hydrogen bond of complex Sal-PI3K and Sal-AKT were 0.79 and 4.46, respectively. The results of LSPR verified the potential binding of Sal to proteins PI3K, AKT and HIF-1 alpha with affinity values of 5.20 x 10 -3, 2.83 x 10 -3 and 3.97 x 10 -3 KD, respectively. Western blot analysis further argued that Sal consolidated the levels of p-PI3K and p-AKT. Mean-while, Sal could downregulate the proteins expression of p-JNK and p-p38.
   Conclusion: Collectively, our findings suggested that Sal can intensify mitochondrial function of CoCl2-simulated hypoxia injury in HT22 cells by stimulating PI3K-AKT-MAPK signaling pathway. Sal is a potential agent for mitochondrial protection against hypoxia with the underlying molecular mechanisms of energy metabolism being further elucidated.
C1 [Hou, Ya; Zhang, Yating; Jiang, Shengnan; Xie, Na; Zhang, Yi; Meng, Xianli] Chengdu Univ Tradit Chinese Med, Sch Pharm, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China.
   [Meng, Xianli; Wang, Xiaobo] Chengdu Univ Tradit Chinese Med & Pharm, Innovat Inst Chinese Med, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine
RP Meng, XL (corresponding author), Chengdu Univ Tradit Chinese Med, Sch Pharm, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China.; Meng, XL; Wang, XB (corresponding author), Chengdu Univ Tradit Chinese Med & Pharm, Innovat Inst Chinese Med, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China.
EM xlm999@cdutcm.edu.cn; VitaDrwang@cdutcm.edu.cn
FU National Natural Science Foundation of China [82104533, 81973569]; China
   Postdoctoral Science Foundation [2020M683273]; Science & Technology
   Department of Sichuan Province [2021YJ0175]
FX This work was supported by the National Natural Science Foundation of
   China (82104533 and 81973569) , the China Postdoctoral Science
   Foundation (2020M683273) , the Science & Technology Department of
   Sichuan Province (2021YJ0175) . The authors would like to thank Mr.
   Jiayi Sun, at the Innovative Institute of Chinese Medicine and Pharmacy,
   Chengdu University of Traditional Chinese Medicine, Chengdu, China, for
   providing technical services for laser confocal instrument.
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NR 69
TC 79
Z9 85
U1 20
U2 152
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD JAN
PY 2023
VL 109
AR 154568
DI 10.1016/j.phymed.2022.154568
EA JAN 2023
PG 16
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA 8K9YD
UT WOS:000923447300001
PM 36610162
DA 2026-05-27
ER

PT J
AU Li, SC
   Sun, X
   Bi, L
   Tong, YJ
   Liu, X
AF Li, Sicong
   Sun, Xu
   Bi, Lei
   Tong, Yujia
   Liu, Xin
TI Research Progress on Natural Product Ingredients' Therapeutic Effects on
   Parkinson's Disease by Regulating Autophagy
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Review
ID ASTRAGALOSIDE-IV; ALPHA-SYNUCLEIN; BETA-ASARONE; MUCUNA-PRURIENS;
   OXIDATIVE STRESS; PC12 CELLS; SIGNALING PATHWAY; INDUCED APOPTOSIS;
   ISCHEMIC-STROKE; MOUSE MODEL
AB Parkinson's disease (PD) is a common neurodegenerative disease in middle-aged and older adults. Abnormal proteins such as alpha-synuclein are essential factors in PD's pathogenesis. Autophagy is the main participant in the clearance of abnormal proteins. The overactive or low function of autophagy leads to autophagy stress. Not only is it difficult to clear abnormal proteins but also it can cause damage to neurons. In this article, the effects of natural products ingredients, such as salidroside, paeoniflorin, curcumin, resveratrol, corynoxine, and baicalein, on regulating autophagy and protecting neurons were discussed in detail to provide a reference for the research and development of drugs for the treatment of PD.
C1 [Li, Sicong] Peking Univ Hlth Sci Ctr, Sch Pharm, Beijing, Peoples R China.
   [Sun, Xu] Guangzhou Univ Tradit Chinese Med, Dept Pharm, Affiliated Hosp 1, Guangzhou, Peoples R China.
   [Bi, Lei; Liu, Xin] Beijing Univ Tradit Chinese Med, Sch Tradit Chinese Med, Beijing 100029, Peoples R China.
   [Tong, Yujia] Chinese Acad Med Sci Peking Union Med Coll, Inst Med Informat, Beijing, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Beijing University of Chinese
   Medicine; Chinese Academy of Medical Sciences - Peking Union Medical
   College; Peking Union Medical College
RP Liu, X (corresponding author), Beijing Univ Tradit Chinese Med, Sch Tradit Chinese Med, Beijing 100029, Peoples R China.
EM lisicong32@163.com; sxapril@163.com; learn1972@163.com;
   tongyoga@163.com; xinliu1011@126.com
OI bi, lei/0000-0002-2004-4356; Li, Sicong/0000-0002-6414-6645; Liu,
   Xin/0000-0003-3593-3460; 童, 俞嘉/0000-0002-2348-842X
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NR 117
TC 9
Z9 12
U1 2
U2 64
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PD APR 24
PY 2021
VL 2021
AR 5538200
DI 10.1155/2021/5538200
PG 11
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA SX0EX
UT WOS:000664886400002
PM 33981351
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Chang, YX
   Lin, JJ
   Pan, SQ
   Jing, YL
   Guo, AL
   Deng, Y
AF Chang Yuexing
   Lin Junjie
   Pan Siqing
   Jing Yanlin
   Guo Ailing
   Deng Yun
TI Effects of Different Drying Methods on the Contents of Nine Components
   and Immunomodulatory Activities of Four Components in Osmamthus
   fragrans Flowers
SO NATURAL PRODUCT COMMUNICATIONS
LA English
DT Article
DE bioactivity; Osmamthus fragrans; drying methods; chemical components;
   immunomodulatory activity
ID OSMANTHUS-FRAGRANS; ESSENTIAL OIL; SULFATED POLYSACCHARIDE; VAR.
   AURANTIACUS; SENSORY QUALITY; ANTIOXIDANT; BIOACTIVITIES; EXTRACT
AB The effects of drying methods on the contents of four nonvolatile and five volatile components and the immunoregulatory activities of four components in Osmamthus fragrans flowers were investigated. In general, microwaving preserved more nonvolatile components than the other methods, while the sun or shade method preserved more volatile components. Nonvolatile components such as salidroside and acteoside and volatile ingredients such as linalool and linalool oxide exhibited better immunore atory activity than the other ingredients. Taken together, O. fragrans flowers dried by microwaving resulted in the best immunoregulatory activity. This study provides evidence for the optimal drying method for O. fragrans flowers as food and medicine.
C1 [Chang Yuexing; Lin Junjie; Pan Siqing; Jing Yanlin; Guo Ailing; Deng Yun] Anhui Univ Sci & Technol, Med Sch, Dept Pharm, Huainan, Anhui, Peoples R China.
C3 Anhui University of Science & Technology
RP Chang, YX (corresponding author), Anhui Univ Sci & Technol, Med Sch, 168 Taifeng St, Huainan City 232001, Anhui, Peoples R China.
EM yxchang@aust.edu.cn
OI Chang, Yuexing/0000-0001-6381-3189
FU Anhui University Natural Science Research Projects of China
   [KJ2019A0097]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This work
   was supported by the Anhui University Natural Science Research Projects
   of China under Grant (KJ2019A0097).
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NR 48
TC 3
Z9 3
U1 3
U2 54
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1934-578X
EI 1555-9475
J9 NAT PROD COMMUN
JI Nat. Prod. Commun.
PD FEB
PY 2021
VL 16
IS 2
DI 10.1177/1934578X21996160
PG 9
WC Chemistry, Medicinal; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology
GA QL1HC
UT WOS:000620830000001
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhu, J
   Jin, RY
   Su, M
   Pei, JR
   Chang, YX
   Jiang, MM
AF Zhu, Jian
   Jin, Ruyi
   Su, Mei
   Pei, Jierong
   Chang, Yanxu
   Jiang, Miaomiao
TI Quantitative analysis of active components in Rhodiola species
   based on disease module-guided network pharmacology
SO ARABIAN JOURNAL OF CHEMISTRY
LA English
DT Article
DE Rhodiola species; Chemical profile; Network pharmacology; Quantitative
   analysis; Quality markers
ID SALIDROSIDE
AB Many different species of Rhodiola are traditional botanical medicines with various effects, and their roots and rhizomes are the medicinal parts, which have been recorded in many ancient medical books. The 2020th edition of Chinese Pharmacopoeia stipulates Rhodiola crenulata (Hook. f. et Thoms.) H. Ohba (R. crenulata) as the only medicinal species. However, the wild resources of R. crenulata are gradually decreasing, and it is difficult to achieve artificial cultivation of R. crenulata nowadays. It is important to find several alternative species of R. crenulata. In the present study, an integrated strategy based on chemical profiling, disease module-guided network pharmacology, and quantitative analysis (CDMQ) has been developed to estimate the chemical char-acteristics, determine active components and related disease modules, discover potential quality markers, and identify alternative species in a step-by-step manner for 9 species of Rhodiola. Firstly, a total of 109 compounds were identified in accordance with their retention times, accurate masses and characteristic MS/MS fragment patterns, which mainly included phenylpropanoid glycosides, gallic acid glycosides, flavonoids and their gly-cosides, flavanols, organic acids, and others. Subsequently, disease module-guided network pharmacology analysis was performed based on the related targets of 109 compounds. In combination of the limit of detection of the UPLC-QQQ-MS/MS, 12 compounds were identified as active components. The enriched disease modules of circulatory system, mouth, respiratory system, skin and connective tissue showed close relationship with traditional efficacy of Rhodiola species. It also revealed that salidroside, rhodiosin, epicatechin gallate, catechin gallate, and 6 '-O-galloylsalidroside changed significantly in different species to be served as potential quality markers for Rhodiola. Among the 9 species, Rhodiola kirilowii (Regel) Maxim (R. kirilowii) and Rhodiola sacra (Prain ex Hamet) S.H. Fu (R. sacra) could probably be used as an alternative species of R. crenulata. Overall, this study established a solid foundation and provided theoretical guidance for the chemical profiling, prediction of clinical application, and quality control of different Rhodiola species.
C1 [Zhu, Jian; Jin, Ruyi; Jiang, Miaomiao] Tianjin Univ Tradit Chinese Med, State Key Lab Component Based Chinese Med, 10 Poyanghu Rd, Tianjin 301617, Peoples R China.
   [Su, Mei; Chang, Yanxu] Haihe Lab Modern Chinese Med, Tianjin 301617, Peoples R China.
   [Pei, Jierong] Tianjin Key Lab Therapeut Subst Tradit Chinese Med, Tianjin 301617, Peoples R China.
C3 Tianjin University of Traditional Chinese Medicine
RP Jiang, MM (corresponding author), Tianjin Univ Tradit Chinese Med, State Key Lab Component Based Chinese Med, 10 Poyanghu Rd, Tianjin 301617, Peoples R China.
EM miaomiaojiang@tjutcm.edu.cn
FU Tianjin Committee of Science and Technology of China [23ZYJDSS00030];
   Science and Tech- nology Project of Haihe Laboratory of Modern Chinese
   Medicine [22HHZYSS00007, 22HHZYJC00003]
FX <BOLD>Acknowledgements</BOLD> This study was supported by the Tianjin
   Committee of Science and Technology of China (No. 23ZYJDSS00030) and the
   Science and Tech- nology Project of Haihe Laboratory of Modern Chinese
   Medicine (Nos. 22HHZYSS00007 and 22HHZYJC00003) .
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NR 67
TC 4
Z9 4
U1 19
U2 49
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1878-5352
EI 1878-5379
J9 ARAB J CHEM
JI Arab. J. Chem.
PD FEB
PY 2024
VL 17
IS 2
AR 105570
DI 10.1016/j.arabjc.2023.105570
EA DEC 2023
PG 11
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA FM2O8
UT WOS:001146153200001
OA gold
DA 2026-05-27
ER

PT J
AU Chen, YQ
   Tang, ML
   Yuan, S
   Fu, S
   Li, YF
   Li, Y
   Wang, Q
   Cao, YY
   Liu, LP
   Zhang, QG
AF Chen, Yingqing
   Tang, Minli
   Yuan, Shuo
   Fu, Shuang
   Li, Yifei
   Li, You
   Wang, Qi
   Cao, Yuying
   Liu, Liping
   Zhang, Qinggao
TI Rhodiola rosea: A Therapeutic Candidate on Cardiovascular Diseases
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID OXIDATIVE STRESS; PI3K/AKT PATHWAY; LIFE-SPAN; SALIDROSIDE; INJURY;
   HEART; ATHEROSCLEROSIS; ACTIVATION; APOPTOSIS; FAILURE
AB Cardiovascular diseases, also known as circulatory diseases, are diseases of the heart and blood vessels, and its etiology is hyperlipidemia, thick blood, atherosclerosis, and hypertension. Due to its high prevalence, disability, and mortality, it seriously threatens human health. According to reports, the incidence of cardiovascular disease is still on the rise. Rhodiola rosea is a kind of traditional Chinese medicine, which has the effects of antimyocardial ischemia-reperfusion injury, lowering blood fat, antithrombosis, and antiarrhythmia. Rhodiola rosea has various chemical components, and different chemical elements have the same pharmacological effects and medicinal values for various cardiovascular diseases. This article reviews the research on the pharmacological effects of Rhodiola rosea on cardiovascular diseases and provides references for the clinical treatment of cardiovascular diseases.
C1 [Chen, Yingqing; Tang, Minli; Yuan, Shuo; Fu, Shuang; Li, Yifei; Li, You; Wang, Qi; Liu, Liping; Zhang, Qinggao] Dalian Univ, Chron Dis Res Ctr, Coll Med, Dalian 116622, Liaoning, Peoples R China.
   [Yuan, Shuo] Yanbian Univ, Jilin 133022, Yanji, Peoples R China.
   [Cao, Yuying] Dalian Univ, Zhongshan Hosp, Dalian 116001, Liaoning, Peoples R China.
C3 Dalian University; Yanbian University; Dalian University
RP Liu, LP; Zhang, QG (corresponding author), Dalian Univ, Chron Dis Res Ctr, Coll Med, Dalian 116622, Liaoning, Peoples R China.
EM chenyq1211@163.com; 1070497132@qq.com; yuanqiqi0710@yeah.net;
   1336719871@qq.com; 823674666@qq.com; 424085935@qq.com; 921045357@qq.com;
   caoyuying0821@yeah.net; liuliping@dlu.edu.cn; zhangqinggao@dlu.edu.cn
RI li, yifei/IWU-7824-2023; Yuan, Shuo/KMY-6341-2024; Liu,
   Liping/R-4375-2019; Chen, Yingqing/AAH-1367-2020
OI Zhang, Qing-Gao/0000-0002-7140-3822; wang, qi/0000-0002-0064-9032; Chen,
   Yingqing/0000-0003-2326-7587
FU National Natural Science Foundation of China [82000074]; Liaoning
   Provincial Department of Education [jyt-dldxjc202005]; Dalian University
   Doctoral Program [2020QL023]; Dalian Youth Science and Technology Star
   Research Project [2020RQ080]
FX This paper was supported by the National Natural Science Foundation of
   China (82000074), the Scientific Research Funding Project of Liaoning
   Provincial Department of Education (jyt-dldxjc202005), the Dalian
   University Doctoral Program (2020QL023), and the Dalian Youth Science
   and Technology Star Research Project (2020RQ080).
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NR 75
TC 33
Z9 39
U1 7
U2 76
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD FEB 27
PY 2022
VL 2022
AR 1348795
DI 10.1155/2022/1348795
PG 14
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 0D6QK
UT WOS:000776117500011
PM 35265260
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Al-Otaibi, NAS
   Cassoli, JS
   Martins-de-Souza, D
   Slater, NKH
   Rahmoune, H
AF Al-Otaibi, Noha A. S.
   Cassoli, Juliana S.
   Martins-de-Souza, Daniel
   Slater, Nigel K. H.
   Rahmoune, Hassan
TI Human leukemia cells (HL-60) proteomic and biological signatures
   underpinning cryo-damage are differentially modulated by novel
   cryo-additives
SO GIGASCIENCE
LA English
DT Article
DE cryopreservation; oxidative stress; dimethylsulfoxide; nigerose;
   salidroside
ID OXIDATIVE STRESS; OVARIAN TISSUE; STEM-CELLS; CRYOPRESERVATION;
   VITRIFICATION
AB Background: Cryopreservation is a routinely used methodology for prolonged storage of viable cells. The use of cryo-protective agents (CPAs) such as dimethylsulfoxide (DMSO), glycerol, or trehalose is paramount to reducing cellular cryo-injury, but their effectiveness is still limited. The current study focuses on establishing and modulating the proteomic and the corresponding biological profiles associated with the cryo-injury of human leukemia (HL-60) cells cryopreserved in DMSO alone or DMSO +/-novel CPAs (e. g., nigerose [Nig] or salidroside [Sal]). Findings: To reduce cryo-damage, HL-60 cells were cultured prior and post cryopreservation in malondialdehyde Roswell Park Memorial Institute medium-1640 media +/- Nig or Sal. Shotgun proteomic analysis showed significant alterations in the levels of proteins in cells cryopreserved in Nig or Sal compared to DMSO. Nig mostly affected cellular metabolism and energy pathways, whereas Sal increased the levels of proteins associated with DNA repair/duplication, RNA transcription, and cell proliferation. Validation testing showed that the proteome profile associated with Sal was correlated with a 2.8-fold increase in cell proliferative rate. At the functional level, both Nig and Sal increased glutathione reductase (0.0012 +/- 6.19E-05 and 0.0016 +/- 3.04E-05 mU/mL, respectively) compared to DMSO controls (0.0003 +/- 3.7E-05 mU/mL) and reduced cytotoxicity by decreasing lactate dehydrogenase activities (from -2.5 to -4.75 fold) and lipid oxidation (-1.6 fold). In contrast, only Nig attenuated protein carbonylation or oxidation. Conclusions: We have identified key molecules and corresponding functional pathways underpinning the effect of cryopreservation (+/- CPAs) of HL-60 cells. We also validated the proteomic findings by identifying the corresponding biological profiles associated with promoting an anti-oxidative environment post cryopreservation. Nig or Sal in comparison to DMSO showed differential or additive effects in regard to reducing cryo-injury and enhancing cell survival/proliferation post thaw. These results can provide useful insight to cryo-damage and the design of enhanced cryomedia formulation.
C1 [Al-Otaibi, Noha A. S.; Slater, Nigel K. H.; Rahmoune, Hassan] Univ Cambridge, Dept Chem Engn & Biotechnol, Philippa Fawcett Dr, Cambridge CB3 0AS, England.
   [Al-Otaibi, Noha A. S.] King Abdulaziz City Sci & Technol, POB 6086, Riyadh 11442, Saudi Arabia.
   [Cassoli, Juliana S.; Martins-de-Souza, Daniel] Univ Campinas UNICAMP, Inst Biol, Dept Biochem & Tissue Biol, Lab Neuroprote, Campinas, SP, Brazil.
C3 University of Cambridge; King Abdulaziz City for Science & Technology;
   Universidade de Sao Paulo; Universidade Estadual de Campinas
RP Rahmoune, H (corresponding author), Univ Cambridge, Dept Chem Engn & Biotechnol, Philippa Fawcett Dr, Cambridge CB3 0AS, England.
EM hr228@cam.ac.uk
RI Martins-de-Souza, Daniel/E-7021-2010; Silva Cassoli, Juliana/L-3783-2013
OI Martins-de-Souza, Daniel/0000-0003-3595-5846; Slater,
   Nigel/0000-0002-0207-9440; Rahmoune, Hassan/0000-0002-4889-0992;
   Alotaibi, Noha/0000-0002-7770-604X; Silva Cassoli,
   Juliana/0000-0002-2174-6309
FU King Abdul Aziz City for Science and Technology research fund - FAPESP
   (Sao Paulo Research Foundation) [2014/14 881-1, 2013/0 8711-3, 2014/10
   068-4]; CNPq (the Brazilian National Council for Scientific and
   Technological Development) [460 289/2014-4]
FX This work was supported by the King Abdul Aziz City for Science and
   Technology research fund. J.S.C. and D.,M.S. are funded by FAPESP (Sao
   Paulo Research Foundation, grants 2014/14 881-1, 2013/0 8711-3, and
   2014/10 068-4) and CNPq (the Brazilian National Council for Scientific
   and Technological Development, grant 460 289/2014-4).
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NR 48
TC 6
Z9 7
U1 0
U2 8
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2047-217X
J9 GIGASCIENCE
JI GigaScience
PD MAR
PY 2019
VL 8
IS 3
AR giy155
DI 10.1093/gigascience/giy155
PG 13
WC Biology; Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Science & Technology - Other
   Topics
GA HW5JX
UT WOS:000466726800002
PM 30535373
OA Green Submitted, Green Published, gold
DA 2026-05-27
ER

PT J
AU Cui, LJ
   Ye, C
   Luo, T
   Jiang, HY
   Lai, BA
   Wang, HJ
   Chen, ZY
   Li, Y
AF Cui, Lijuan
   Ye, Chuan
   Luo, Ting
   Jiang, Hongyan
   Lai, Boan
   Wang, Haojun
   Chen, Zhongyi
   Li, Yi
TI Exploring the Pharmacological Action and Molecular Mechanism of
   Salidroside in Inhibiting MCF-7 Cell Proliferation and Migration
SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
LA English
DT Article
ID CANCER; INVOLVEMENT
AB Salidroside (Sal) contains anti-carcinogenic, anti-hypoxic, and anti-inflammatory pharmacological activities. However, its underlying anti-breast cancer mechanisms have been only incompletely elucidated. Hence, this protocol intended to decode the potential of Sal in regulating the PI3K-AKT-HIF-1 & alpha;-FoxO1 pathway in the malignant proliferation of human breast cancer MCF-7 cells. First, the pharmacological activity of Sal against MCF-7 was evaluated by CCK-8 and cell scratch assays. Moreover, the resistance of MCF-7 cells was measured by migration and Matrigel invasion assays. For cell apoptosis and cycle assays, MCF-7 cells were processed in steps with annexin V-FITC/PI and cell cycle-staining detection kits for flow cytometry analyses, respectively. The levels of reactive oxygen species (ROS) and Ca2+ were examined by DCFH-DA and Fluo-4 AM immunofluorescence staining. The activities of Na+- K+-ATPase and Ca2+-ATPase were determined using the corresponding commercial kits. The protein and gene expression levels in apoptosis and the PI3K-AKT-HIF-1 & alpha;-FoxO1 pathway were further determined using western blot and qRT-PCR analyses, respectively. We found that Sal treatment significantly restricted the proliferation, migration, and invasion of MCF-7 cells with dose-dependent effects. Meanwhile, Sal administration also dramatically forced MCF-7 cells to undergo apoptosis and cell cycle arrest. The immunofluorescence tests showed that Sal observably stimulated ROS and Ca2+ production in MCF-7 cells. Further data confirmed that Sal promoted the expression levels of pro-apoptotic proteins, Bax, Bim, cleaved caspase-9/7/3, and their corresponding genes. Consistently, Sal intervention prominently reduced the expression of the Bcl-2, p-PI3K/PI3K, p-AKT/AKT, mTOR, HIF-1 & alpha;, and FoxO1 proteins and their corresponding genes. In conclusion, Sal can be used as a potential herb-derived compound for treating breast cancer, as it may reduce the malignant proliferation, migration, and invasion of MCF-7 cells by inhibiting the PI3K-AKT-HIF-1 & alpha;-FoxO1 pathway.
C1 [Cui, Lijuan; Ye, Chuan; Luo, Ting; Jiang, Hongyan; Lai, Boan; Wang, Haojun; Chen, Zhongyi] Suining Cent Hosp, Pathol Dept, Chenghe, Peoples R China.
   [Li, Yi] Southwest Jiaotong Univ, Gen Surg Day Ward, Dept Gen Surg, Peoples Hosp Chengdu 3, Chengdu, Peoples R China.
   [Li, Yi] Southwest Jiaotong Univ, Affiliated Hosp, Gen Surg Day Ward, Dept Gen Surg, Chengdu, Peoples R China.
C3 Southwest Jiaotong University; Southwest Jiaotong University
RP Li, Y (corresponding author), Southwest Jiaotong Univ, Gen Surg Day Ward, Dept Gen Surg, Peoples Hosp Chengdu 3, Chengdu, Peoples R China.; Li, Y (corresponding author), Southwest Jiaotong Univ, Affiliated Hosp, Gen Surg Day Ward, Dept Gen Surg, Chengdu, Peoples R China.
EM lyi1980@126.com
FU Health Commission of Sichuan Province [120025]
FX This work was supported by the Health Commission of Sichuan Province
   (120025) .
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NR 18
TC 3
Z9 3
U1 0
U2 6
PU JOURNAL OF VISUALIZED EXPERIMENTS
PI CAMBRIDGE
PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA
SN 1940-087X
J9 JOVE-J VIS EXP
JI J. Vis. Exp.
PD JUN
PY 2023
IS 196
DI 10.3791/65634
PG 21
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA K6VA0
UT WOS:001017787900033
PM 37358272
DA 2026-05-27
ER

PT J
AU Nikolaichuk, H
   Studzinski, M
   Choma, IM
AF Nikolaichuk, Hanna
   Studzinski, Marek
   Choma, Irena Maria
TI Effect directed detection of Rhodiola rosea L. root and rhizome
   extract
SO JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
LA English
DT Article
DE Densitometry; EDD; Rhodiola rosea; TLC-DB
ID ACETYLCHOLINESTERASE INHIBITORS; AUTHENTICITY
AB Rhodiola rosea is a well-known adaptogen plant with antioxidant, antidepressant, anti-stress, and anti-dementive properties that seems to be important in the potential treatment of disorders associated with central nervous system such as Alzheimer's disease. The aim of this study was to effect directed detection (EDD) of biologically active substances in the root and rhizome of R. rosea L. based on chemical and biological assays performed directly on a thin-layer chromatography (TLC) plate. TLC-direct bioautography revealed the presence of both antioxidants (DPPH assay) and antibacterials (Bacillus subtilis assay) in the plant methanol extract. Unfortunately, the presence of acetylcholinesterase (AChE) inhibitors was not evident. The marker compounds, typical for R. rosea L. that is salidroside, rosavin, p-tyrosol, and hydroquinone were searched in the extract using TLC densitometry. In fact, only rosavin was found in the investigated extract.
C1 [Nikolaichuk, Hanna; Choma, Irena Maria] Marie Curie Sklodowska Univ, Inst Chem Sci, Fac Chem, Dept Chromatog, Lublin, Poland.
   [Studzinski, Marek] Marie Curie Sklodowska Univ, Inst Chem Sci, Fac Chem, Dept Phys Chem, Lublin, Poland.
C3 Maria Curie-Sklodowska University; Maria Curie-Sklodowska University
RP Choma, IM (corresponding author), Marie Curie Sklodowska Univ, Inst Chem Sci, Fac Chem, Dept Chromatog, Lublin, Poland.
EM irena.choma@poczta.umcs.lublin.pl
RI Choma, Irena/AAG-9790-2021; Studziński, Marek/D-4824-2011
OI Choma, Irena/0000-0002-6878-3748; Nikolaichuk,
   Hanna/0000-0001-6292-483X; Studziński, Marek/0000-0001-8226-1922
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NR 25
TC 4
Z9 5
U1 0
U2 31
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1082-6076
EI 1520-572X
J9 J LIQ CHROMATOGR R T
JI J. Liq. Chromatogr. Relat. Technol.
PD JUL 20
PY 2020
VL 43
IS 11-12
BP 361
EP 366
DI 10.1080/10826076.2020.1725549
EA FEB 2020
PG 6
WC Biochemical Research Methods; Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA ME2IZ
UT WOS:000513980000001
DA 2026-05-27
ER

PT J
AU Wan, SL
   Yang, R
   Zhang, H
   Li, XL
   Gu, MX
   Guan, TB
   Ren, JB
   Sun, HM
   Dai, CY
AF Wan, Shulin
   Yang, Rui
   Zhang, Han
   Li, Xuelian
   Gu, Mingxian
   Guan, Tianbing
   Ren, Jianbing
   Sun, Huimin
   Dai, Chuanyun
TI Application of the SeDeM Expert System in Studies for Direct Compression
   Suitability on Mixture of Rhodiola Extract and an Excipient
SO AAPS PHARMSCITECH
LA English
DT Article
DE SeDeM expert system; preformulation; direct compression; rhodiola
   extract
ID SALIDROSIDE; PREFORMULATION; TABLETS; DIAGRAM
AB The SeDeM expert system is used to reveal direct compression (DC) suitability of the active ingredients and excipients in preformulation. In this study, the system was used to predict compressibility of rhodiola extract (RhE) and its mixture with excipients. The parameter index (IP), parameter profile index (IPP), and good compressibility index (IGC) of RhE mixtures with different fillers were investigated. The results showed that RhE and mixture with lactose or starch were not suitable for DC according to the values of IP, IPP, and IGC, which can be corrected by pregelatinized starch (P-STA). The quality of tablets corrected by P-STA all satisfied the USP monograph limit. The findings from this study showed that the system is a useful tool to predict DC suitability on the mixture of RhE and an excipient.
C1 [Wan, Shulin; Zhang, Han; Li, Xuelian; Gu, Mingxian; Guan, Tianbing; Ren, Jianbing; Dai, Chuanyun] Chongqing Univ Sci & Technol, 20 Univ City East Rd, Chongqing 401331, Peoples R China.
   [Yang, Rui; Sun, Huimin] Natl Inst Food & Drug Control, 2 Tiantan Xili Rd, Beijing 100050, Peoples R China.
   [Ren, Jianbing] Chongqing LIYUN Nozzle Co Ltd, 98 Xiyuan 2nd Rd, Chongqing 401332, Peoples R China.
C3 Chongqing University of Science & Technology; National Institute of Food
   & Drug Control - China
RP Dai, CY (corresponding author), Chongqing Univ Sci & Technol, 20 Univ City East Rd, Chongqing 401331, Peoples R China.; Sun, HM (corresponding author), Natl Inst Food & Drug Control, 2 Tiantan Xili Rd, Beijing 100050, Peoples R China.
EM sunhm@126.com; cydai@cqust.edu.cn
RI Li, Xuelian/ABF-9104-2020; dai, chuanyun/ABE-3233-2021
OI dai, chuanyun/0000-0001-8890-3017
FU National Science & Technology Major Project Key New Drug Creation and
   Manufacturing Program [2015ZX09303001002007]; Industrial Key Research
   and Development Project of the Chongqing Science & Technology Commission
   [cstc2017zdcy-cdyf193]; Postgraduate Science and Technology Innovation
   Program of Chongqing University of Science and Technology [YKJCX1820507]
FX We wish to thank Anhui Shanhe Medicinal Excipients Co., Ltd., China, and
   Meggle Pharma-Excipients & Technology Co., Ltd., Germany, for providing
   the necessary materials to carry out this study. This work has emanated
   from research conducted with the financial support of the National
   Science & Technology Major Project Key New Drug Creation and
   Manufacturing Program (2015ZX09303001002007), the Industrial Key
   Research and Development Project of the Chongqing Science & Technology
   Commission (cstc2017zdcy-cdyf193), and the Postgraduate Science and
   Technology Innovation Program of Chongqing University of Science and
   Technology (YKJCX1820507).
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NR 33
TC 15
Z9 22
U1 0
U2 26
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1530-9932
J9 AAPS PHARMSCITECH
JI AAPS PharmSciTech
PD APR
PY 2019
VL 20
IS 3
AR 105
DI 10.1208/s12249-019-1320-4
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HL0AL
UT WOS:000458355900004
PM 30746569
DA 2026-05-27
ER

PT J
AU Liu, Y
   Chen, ZC
   Li, AJ
   Liu, RH
   Yang, HY
   Xia, X
AF Liu, Yang
   Chen, Zhouchun
   Li, Aijie
   Liu, Runhan
   Yang, Haoying
   Xia, Xue
TI The Phytochemical Potential for Brain Disease Therapy and the Possible
   Nanodelivery Solutions for Brain Access
SO FRONTIERS IN ONCOLOGY
LA English
DT Review
DE phytochemicals; blood-brain barrier; brain diseases; nanodelivery;
   therapeutics development
ID DRUG-DELIVERY; MOUSE MODEL; IN-VITRO; NEUROPROTECTIVE AGENT; ADJUVANT
   TEMOZOLOMIDE; BARRIER; LUTEOLIN; NANOPARTICLES; GLIOBLASTOMA;
   SALIDROSIDE
AB Plant-derived phytochemicals have gifted humans with vast therapeutic potentials. Yet, the unique features of the blood-brain barrier significantly limit their accession to the target tissue and thus clinical translation in brain disease treatment. Herein, we explore the medicinal outcomes of both the rare examples of phytochemicals that can easily translocate across the blood-brain barrier and most of the phytochemicals that were reported with brain therapeutic effects, but a bizarre amount of dosage is required due to their chemical nature. Lastly, we offer the nanodelivery platform that is capable of optimizing the targeted delivery and application of the non-permeable phytochemicals as well as utilizing the permeable phytochemicals for boosting novel applications of nanodelivery toward brain therapies.
C1 [Liu, Yang; Chen, Zhouchun; Li, Aijie; Liu, Runhan; Yang, Haoying; Xia, Xue] Henan Univ, Henan Macquarie Univ Joint Ctr Biomed Innovat, Sch Life Sci, Kaifeng, Henan, Peoples R China.
   [Liu, Yang; Chen, Zhouchun; Li, Aijie; Liu, Runhan; Yang, Haoying; Xia, Xue] Henan Univ, Sch Life Sci & Sch Pharm, Henan Key Lab Brain Targeted Bionanomed, Kaifeng, Peoples R China.
C3 Henan University; Henan University
RP Xia, X (corresponding author), Henan Univ, Henan Macquarie Univ Joint Ctr Biomed Innovat, Sch Life Sci, Kaifeng, Henan, Peoples R China.; Xia, X (corresponding author), Henan Univ, Sch Life Sci & Sch Pharm, Henan Key Lab Brain Targeted Bionanomed, Kaifeng, Peoples R China.
EM x.xia@henu.edu.cn
RI LIU, Yang/KHX-6807-2024; Xia, Xue/LDF-3270-2024
OI LIU, Yang/0000-0002-8752-4346; 
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NR 103
TC 28
Z9 28
U1 0
U2 16
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2234-943X
J9 FRONT ONCOL
JI Front. Oncol.
PD JUN 23
PY 2022
VL 12
AR 936054
DI 10.3389/fonc.2022.936054
PG 11
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 2S5DR
UT WOS:000821813100001
PM 35814371
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Song, JA
   Zhao, LL
   Rui, W
   Guo, J
   Feng, YF
AF Song, Jianao
   Zhao, Lili
   Rui, Wen
   Guo, Jiao
   Feng, Yifan
TI IDENTIFICATION AND FRAGMENTATION PATTERN ANALYSIS OF IRIDOID GLYCOSIDES
   FROM FRUCTUS LIGUSTRI LUCIDI BY UPLC/ESI-QTOF-MS
SO JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
LA English
DT Article
DE UPLC-Q-TOF-MS; Ligustrum lucidum Ait; iridoid glycosides;
   identification; fragmentation pattern analysis; traditional Chinese
   medicine
ID LIQUID-CHROMATOGRAPHY
AB We herein developed an ultra-performance liquid chromatography coupled with an electrospray ionization quadruple time-of-flight tandem mass spectrometry (UPLC/ESI-QTOF-MS) for the first time to characterize 12 iridoid glycosides from Fructus Ligustri Lucidi (FLL), a commonly used traditional Chinese medicinal herb for the treatment of kidney-deficiency and osteoporosis. In this study, a rapid and effective method was established to analyze iridoid glycosides, and 12 iridoid glycosides were detected and identified by high accurate MS data using Masslynx software. The results reveal that the iridoid glycosides were subjected to deglycosylation, major fragmentation, McLafferty rearrangement and ring cleavage, successively. Salidroside was firstly found in FLL. We have demonstrated UPLC/ESI-QTOF-MS is feasible to rapidly and reliably characterize the iridoid glycosides in FLL.
C1 [Song, Jianao; Zhao, Lili; Rui, Wen; Feng, Yifan] Guangdong Pharmaceut Univ, Ctr Lab, Guangzhou 510006, Guangdong, Peoples R China.
   [Guo, Jiao] Guangdong TCM Key Lab Metab Dis, Key Unit Modulating Liver Treat Hyperlipemia SATC, Level Lab Lipid Metab SATCM 3, Guangzhou, Guangdong, Peoples R China.
C3 Guangdong Pharmaceutical University
RP Feng, YF (corresponding author), Guangdong Pharmaceut Univ, Ctr Lab, Guangzhou 510006, Guangdong, Peoples R China.
EM yffeng@139.com
RI Zhao, Lili/HSI-4541-2023; Guo, Jiao/PFK-0669-2025
OI Guo, Jiao/0000-0002-0050-5055
FU Guangdong Natural Science Foundation [10351022401000000]; Cooperative
   Project in Industry, Education, and Research of Guangdong Province;
   Ministry of Education of China [2011B090400379]
FX This study was financially supported by the Project Supported by
   Guangdong Natural Science Foundation (10351022401000000), and the
   Cooperative Project in Industry, Education, and Research of Guangdong
   Province and the Ministry of Education of China (2011B090400379).
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NR 11
TC 7
Z9 10
U1 0
U2 71
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1082-6076
EI 1520-572X
J9 J LIQ CHROMATOGR R T
JI J. Liq. Chromatogr. Relat. Technol.
PD JUL 21
PY 2014
VL 37
IS 12
BP 1763
EP 1770
DI 10.1080/10826076.2013.809544
PG 8
WC Biochemical Research Methods; Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA AE5QC
UT WOS:000334042700010
DA 2026-05-27
ER

PT J
AU Liu, K
   Chen, HL
   You, QS
   Ye, Q
   Wang, F
   Wang, S
   Zhang, SL
   Yu, KJ
   Lu, Q
AF Liu, Kun
   Chen, Honglin
   You, Qing-Sheng
   Ye, Qing
   Wang, Fei
   Wang, Shuo
   Zhang, Shuang-Long
   Yu, Kang-Jun
   Lu, Qi
TI Curcumin attenuates myocardial ischemia-reperfusion injury
SO ONCOTARGET
LA English
DT Article
DE curcumin; myocardial ischemia-reperfusion; inflammation
ID ACUTE LUNG INJURY; RATS; KINASE; SALIDROSIDE; PATHWAY; INFLAMMATION;
   INHIBITION; MICE
AB Background: Cardiovascular diseases (CVDs) are at a badly high-risk of morbidity and mortality in the world.
   Methods: Our study was attempted to investigate the cardioprotective role of curcumin. Hearts injury was assessed in isolated hearts and the rats of coronary artery ligated.
   Results and Conclusions: The inhibition of pro-inflammatory cytokines was observed by curcumin in coronary artery ligated rats. ST segment was also reduced by curcumin. Triphenyltetrazolium chloride staining (TTC) staining and pathological analysis were also showed that curcumin could dramatically alleviate myocardial injury. Besides, the results in vitro also demonstrated that curcumin could improved the function of isolated hearts. Besides, the expressions of inflammation-related pathway in both rats and isolated hearts treated with curcumin were significantly decreased. The present study investigated the protective effects of curcumin on myocardial injury and its mechanism.
C1 [Liu, Kun; You, Qing-Sheng; Wang, Fei; Wang, Shuo; Zhang, Shuang-Long; Yu, Kang-Jun] Nantong Univ, Affiliated Hosp, Dept Cardiothorac Surg, Nantong, Peoples R China.
   [Chen, Honglin] Nantong Univ, Sch Nursing, Nantong, Peoples R China.
   [Ye, Qing] Nantong Univ, Affiliated Hosp, Dept Obstet & Gynecol, Nantong, Peoples R China.
   [Lu, Qi] Nantong Univ, Affiliated Hosp, Dept Cardiol, Nantong, Peoples R China.
C3 Nantong University; Nantong University; Nantong University; Nantong
   University
RP Lu, Q (corresponding author), Nantong Univ, Affiliated Hosp, Dept Cardiol, Nantong, Peoples R China.
EM ntluqi@sina.com
RI Chen, Hong-Lin/E-5418-2010
FU Six Talent Peaks Project in Jiangsu Province, China [2014-YY-006,
   2016-WSN-103]; China Postdoctoral Science Foundation of China
   [2013M541705]; Postdoctoral Research Foundation of Jiangsu Province,
   China [1301072C]; Science Foundation of Nantong City, Jiangsu Province,
   China [MS32015016, MS32015030]; Natural Science Foundation of Jiangsu
   Province, China [BK20171257]; "333 Project" of Jiangsu Province, China
   [BRA2017557]
FX This work was supported by grants from Six Talent Peaks Project in
   Jiangsu Province, China (no. 2014-YY-006 and no. 2016-WSN-103), the
   China Postdoctoral Science Foundation of China (no. 2013M541705), the
   Postdoctoral Research Foundation of Jiangsu Province, China (no.
   1301072C) and the Science Foundation of Nantong City, Jiangsu Province,
   China (no. MS32015016 and no. MS32015030), the Natural Science
   Foundation of Jiangsu Province, China (no. BK20171257), the "333
   Project" of Jiangsu Province, China (no. BRA2017557).
CR Chang XY, 2016, INT J CARDIOL, V215, P532, DOI 10.1016/j.ijcard.2016.04.108
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NR 17
TC 23
Z9 27
U1 2
U2 38
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
EI 1949-2553
J9 ONCOTARGET
JI Oncotarget
PD DEC 19
PY 2017
VL 8
IS 67
BP 112051
EP 112059
DI 10.18632/oncotarget.23002
PG 9
WC Oncology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Cell Biology
GA FS1VO
UT WOS:000419567000103
PM 29340110
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Marchev, AS
   Aneva, IY
   Koycheva, IK
   Georgiev, MI
AF Marchev, Andrey S.
   Aneva, Ina Y.
   Koycheva, Ivanka K.
   Georgiev, Milen I.
TI Phytochemical variations of Rhodiola rosea L. wild-grown in Bulgaria
SO PHYTOCHEMISTRY LETTERS
LA English
DT Article; Proceedings Paper
CT International Symposium on Chromatography of Natural Products (ISCNP)
CY 2016
CL Lublin, POLAND
DE Golden root; Phenylethanoids; Phenylpropanoids; NMR; Multivariate data
   analysis; HPLC
ID LIQUID-CHROMATOGRAPHY; FLAVONOIDS; GLYCOSIDES; AGE
AB Rhodiola rosea L. is a plant species with highly recognized adaptogenic properties and hence with an intensive application in traditional medicine, as well as, in clinical practice. The plant is characterized by a high phytochemical variability, depending on the geographical location among others. In this study, we report on the application of NMR-based metabolomics (1D and 2D) combined with multivariate data analysis and an HPLC method development for quantitative determination of the metabolic differences in R. rosea rhizomes, roots and aerial parts from its natural habitat in Bulgaria.
   In the rhizomes the content of salidroside, rosarin, rosavin and rosin was 2.67%, 0.37%, 1.97% and 0.04%, respectively, while their respective amounts in the roots were 0.31%, 0.06%, 0.39% and 0.01%. (C) 2016 Phytochemical Society of Europe. Published by Elsevier Ltd. All rights reserved.
C1 [Marchev, Andrey S.; Koycheva, Ivanka K.; Georgiev, Milen I.] Bulgarian Acad Sci, Stephan Angeloff Inst Microbiol, Grp Plant Cell Biotechnol & Metabol, 139 Ruski Blvd, Plovdiv 4000, Bulgaria.
   [Aneva, Ina Y.] Bulgarian Acad Sci, Inst Biodivers & Ecosyst Res, BU-1113 Sofia, Bulgaria.
C3 Bulgarian Academy of Sciences; Stephan Angeloff Institute of
   Microbiology, Bulgarian Academy of Sciences; Bulgarian Academy of
   Sciences
RP Marchev, AS; Georgiev, MI (corresponding author), Bulgarian Acad Sci, Stephan Angeloff Inst Microbiol, Grp Plant Cell Biotechnol & Metabol, 139 Ruski Blvd, Plovdiv 4000, Bulgaria.
EM andrey.marchev@yahoo.com; milengeorgiev@gbg.bg
RI Georgiev, Milen I/P-6948-2015; Marchev, Andrey/PFR-2450-2026; Aneva,
   Ina/AAI-4487-2020
OI Georgiev, Milen I/0000-0001-5248-6135; Marchev,
   Aney/0000-0002-7660-683X; Aneva, Ina/0000-0002-6476-5438; Koycheva,
   Ivanka/0000-0002-0785-2308
FU Program for career development of young scientists, Bulgarian Academy of
   Sciences [DFNP58]
FX The study was supported by Program for career development of young
   scientists, Bulgarian Academy of Sciences, Project no. DFNP58.
CR Booker A, 2016, PHYTOMEDICINE, V23, P754, DOI 10.1016/j.phymed.2015.10.006
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   The United States Pharmacopeial Convention, 2016, RHOD ROS ROOT RHIZ
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   Varejao EVV, 2013, QUIM NOVA, V36, P1004, DOI 10.1590/S0100-40422013000700014 
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NR 23
TC 28
Z9 32
U1 0
U2 28
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1874-3900
EI 1876-7486
J9 PHYTOCHEM LETT
JI Phytochem. Lett.
PD JUN
PY 2017
VL 20
BP 386
EP 390
DI 10.1016/j.phytol.2016.12.030
PG 5
WC Plant Sciences; Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Plant Sciences; Pharmacology & Pharmacy
GA FA5FF
UT WOS:000405467600071
DA 2026-05-27
ER

PT J
AU Li, CW
   Liang, HJ
   Zhang, ZX
   Wang, ZY
   Yu, L
   Liu, HX
   An, FL
   Wang, SH
   Ma, LX
   Xue, WH
AF Li, Changwei
   Liang, Haijing
   Zhang, Zhan-xin
   Wang, Zhaoyan
   Yu, Lan
   Liu, Huanxiang
   An, Fengli
   Wang, Shaohua
   Ma, Lixia
   Xue, Weihua
TI A catalytic Koenigs-Knorr glycosylation based on acceptor activation
   with In(NTf2)3
SO TETRAHEDRON
LA English
DT Article
DE Koenigs-Knorr glycosylation; Acceptor activation; In(NTf2)(3);
   Catalytic; Stereoselective
ID GOLD(I)-CATALYZED GLYCOSYLATION; STEREOSELECTIVE-SYNTHESIS; CHEMICAL
   GLYCOSYLATION; GLYCOSIDES; DONORS; OLIGOSACCHARIDES; ALKYNYLBENZOATES;
   GLYCOBIOLOGY; SALIDROSIDE; ANALOGS
AB The development of efficient glycosylation methods is important for gaining better insight into biological processes of significance to medicinal chemistry. Herein, we describe an In(NTf2)(3)-catalyzed Koenigs-Knorr glycosylation based on the activation of an alcoholic hydroxyl group. A catalytic amount of In(NTf2)(3) enables effective glycosylation of diverse alcohols with peracylated aldosyl bromides as donors, leading to the stereoselective formation of a series of glycosides in satisfactory yields. The protocol is characterized by mild reaction conditions and good functional-group tolerance, while obviating any need for any additive. Moreover, the potential utility of this transformation is demonstrated by the convenient syntheses of key building blocks for biomolecules of medicinal relevance. (C) 2018 Published by Elsevier Ltd.
C1 [Li, Changwei; Liang, Haijing; Zhang, Zhan-xin; Wang, Zhaoyan; Yu, Lan; Liu, Huanxiang; An, Fengli; Wang, Shaohua; Ma, Lixia; Xue, Weihua] Lanzhou Univ, Sch Pharm, Lanzhou 730000, Gansu, Peoples R China.
C3 Lanzhou University
RP Xue, WH (corresponding author), Lanzhou Univ, Sch Pharm, Lanzhou 730000, Gansu, Peoples R China.
EM xuewh@lzu.edu.cn
RI Liu, Huanxiang/C-9690-2013; Wang, Shao-Hua/AGJ-2505-2022; yu,
   lan/LWI-1332-2024
OI Liu, Huanxiang/0000-0002-9284-3667; 
FU National Science Foundation of China [51501080, 21772071, 21675070,
   21405067, 31670350]; Fundamental Research Funds for the Central
   Universities, Lanzhou University [lzujbky-2017-207, lzujbky-2017-k24,
   lzujbky-2017-k25]
FX The work was supported by the National Science Foundation of China
   (51501080, 21772071, 21675070, 21405067 and 31670350) and the
   Fundamental Research Funds for the Central Universities, Lanzhou
   University (lzujbky-2017-207, lzujbky-2017-k24, and lzujbky-2017-k25).
   We gratefully acknowledge the financial support from the Fundamental
   Research Funds for the Central Universities, Lanzhou University
   (lzujbky-2017-207, lzujbky-2017-k24, and lzujbky-2017-k25).
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NR 37
TC 11
Z9 11
U1 1
U2 33
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0040-4020
J9 TETRAHEDRON
JI Tetrahedron
PD JUL 19
PY 2018
VL 74
IS 29
BP 3963
EP 3970
DI 10.1016/j.tet.2018.05.080
PG 8
WC Chemistry, Organic
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC); Current Chemical Reactions (CCR-EXPANDED)
SC Chemistry
GA GM3LG
UT WOS:000438005500005
DA 2026-05-27
ER

PT J
AU Alipieva, KI
   Taskova, RM
   Evstatieva, LN
   Handjieva, NV
   Popov, SS
AF Alipieva, KI
   Taskova, RM
   Evstatieva, LN
   Handjieva, NV
   Popov, SS
TI Benzoxazinoids and iridoid glucosides from four Lamium species
SO PHYTOCHEMISTRY
LA English
DT Article
DE Lamium; Lamiaceae; benzoxazinoids; iridoid glucosides; chemotaxonomy
ID CYCLIC HYDROXAMIC ACIDS; BENZOXAZOLINONE; IDENTIFICATION; GLYCOSIDES
AB A new class of compounds for the plant family Lamiaceae, benzoxazinoids, was found in Lamium galeobdolon. From the aerial parts of the species were isolated the new 2-O-beta-D-glucopyranosyl-6-hydroxy-2H-1,4-benzoxazin-3(4H)-one (6-hydroxy blepharin) together with four known benzoxazinoids, DHBOA-Glc, blepharin, DIBOA, DIBOA-Glc, as well as harpagide, 8-O-acetyl-harpagide and salidroside. Eight known iridoid glucosides, 24-epi-pterosterone and verbascoside were isolated from Lamium amplexicaule, L. purpureum and L. garganicum. The iridoids, 5-deoxylamiol and sesamoside, as well as the phytoecdysone, 24-epi-pterosterone, were found for the first time for the genus Lamium. The phytochemical data are discussed from a systematic and evolutionary point of view. (C) 2003 Elsevier Ltd. All rights reserved.
C1 Bulgarian Acad Sci, Inst Organ Chem, Ctr Phytochem, BU-1113 Sofia, Bulgaria.
   Bulgarian Acad Sci, Inst Bot, BU-1113 Sofia, Bulgaria.
C3 Bulgarian Academy of Sciences; Bulgarian Academy of Sciences
RP Handjieva, NV (corresponding author), Bulgarian Acad Sci, Inst Organ Chem, Ctr Phytochem, BU-1113 Sofia, Bulgaria.
EM nechy@orgchm.bas.bg
RI Alipieva, Kalina/HTN-5677-2023
OI Alipieva, Kalina/0000-0003-2395-5339
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NR 35
TC 65
Z9 72
U1 0
U2 29
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9422
EI 1873-3700
J9 PHYTOCHEMISTRY
JI Phytochemistry
PD DEC
PY 2003
VL 64
IS 8
BP 1413
EP 1417
DI 10.1016/j.phytochem.2003.08.001
PG 5
WC Biochemistry & Molecular Biology; Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Biochemistry & Molecular Biology; Plant Sciences
GA 747KT
UT WOS:000186804200015
PM 14630008
DA 2026-05-27
ER

PT J
AU Mácsai, L
   Datki, ZL
   Csupor, D
   Horváth, A
   Zomborszki, ZP
AF Macsai, Lilla
   Datki, Zsolt L.
   Csupor, Dezso
   Horvath, Attila
   Zomborszki, Zoltan P.
TI Biological Activities of Four Adaptogenic Plant Extracts and Their
   Active Substances on a Rotifer Model
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
AB Rotifers have been widely used as well-characterized models of aging, since their multiorgan character makes them suitable as in vivo toxicological and lifespan models. Here we report the assessment of four adaptogenic plants and their extracts for the first time in this model. The effects on rotifer viability of extracts and characteristic active markers of Panax ginseng, Withania somnifera, Leuzea carthamoides, and Rhodiola rosea were tested in vivo. The crude extracts were nontoxic to Philodina acuticornis bdelloid rotifers; however, the pure substances of the plants influenced negatively the viability. Ginsenoside Rb1 and secondary metabolites of Withania somnifera exerted deleterious effect on the animals. The aglycone tyrosol and cinnamyl alcohol (from Rhodiola rosea) were more toxic than their glycosides salidroside and rosavin. Although the 20-OH-ecdysone and ajugasterone C (from Leuzea carthamoides) are chemically very similar, the latter was less toxic.
C1 [Macsai, Lilla; Datki, Zsolt L.] Univ Szeged, Fac Med, Dept Psychiat, H-6720 Szeged, Hungary.
   [Csupor, Dezso; Horvath, Attila; Zomborszki, Zoltan P.] Univ Szeged, Fac Pharm, Dept Pharmacognosy, H-6720 Szeged, Hungary.
C3 Szeged University; Szeged University
RP Csupor, D (corresponding author), Univ Szeged, Fac Pharm, Dept Pharmacognosy, H-6720 Szeged, Hungary.
EM csupor.dezso@pharmacognosy.hu
RI Csupor, Dezső/ABE-1830-2021
OI Csupor, Dezső/0000-0002-4088-3333; Borbélyné Mácsai,
   Lilla/0000-0002-9503-6449
FU National Research, Development and Innovation Office [OTKA K115796];
   Economic Development and Innovation Operative Programme
   [GINOP-2.3.2-15-2016-00012]; Janos Bolyai Research Scholarship of the
   Hungarian Academy of Sciences
FX The authors thank Wieland Peschel for his inspiring cooperation on the
   topic of adaptogenic plants and for providing plant material for these
   studies. This work was supported by the National Research, Development
   and Innovation Office [OTKA K115796], Economic Development and
   Innovation Operative Programme [GINOP-2.3.2-15-2016-00012], and Janos
   Bolyai Research Scholarship of the Hungarian Academy of Sciences.
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NR 12
TC 7
Z9 10
U1 0
U2 13
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2018
VL 2018
AR 3690683
DI 10.1155/2018/3690683
PG 4
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA GY4GN
UT WOS:000448519600001
PM 30405739
OA Green Submitted, Green Accepted, hybrid
DA 2026-05-27
ER

PT J
AU Moreno-González, R
   Juan, ME
   Planas, JM
AF Moreno-Gonzalez, Rocio
   Emilia Juan, M.
   Planas, Joana M.
TI Table olive polyphenols: A simultaneous determination by liquid
   chromatography-mass spectrometry
SO JOURNAL OF CHROMATOGRAPHY A
LA English
DT Article
DE Hydroxytyrosol; LC-ESI-MS/MS; Olea europaea L.; Luteolin; Tyrosol; Table
   olives
ID SPANISH-STYLE GREEN; PHENOLIC-COMPOUNDS; BLACK RIPE; FRUIT; OLEUROPEIN;
   ARBEQUINA; FERMENTATION; QUANTITATION; BIOPHENOLS; PROFILE
AB Table olives contain a wide range of polyphenols responsible for protective effects on health that have been associated with a lower prevalence of chronic diseases. A new method to identify and quantify these compounds in table olives, by means of methanol:ethanol (1:1; v/v) extraction followed by LC-ESI-MS/MS, has been developed and validated. The chromatographic column Eclipse-XDB-C18, never used before in this kind of application, provided the best results using Milli-Q water with 0.025% acetic acid and acetonitrile with 5% acetone as eluents. This method allows the quantification of 17 polyphenols, namely, hydroxytyrosol, tyrosol, salidroside, hydroxytyrosol acetate, catechol, vanillic acid, caffeic acid, o-coumaric acid, p-coumaric acid, verbascoside; oleuropein: pinoresinol, apigenin, luteolin, luteolin-7-O-glucoside, quercetin and rutin. The new method has been validated and shows linear correlations (R-2>0.996), recoveries superior to 95%, high sensitivity, adequate precision and accuracy (RSD < 15%) as well as a short chromatographic analysis of 9 min. Its application to the analysis of Marfil table olives enabled the quantification of 15 polyphenols, among which hydroxytyrosol (384.1 +/- 1 81.2 mg/kg), tyrosol (201.2 +/- 3.8 mg/kg), luteolin (88.0 +/- 3.8 mg/kg) and salidroside (85.9 +/- 13.2 mg/kg) stand out. Furthermore, this method allows to assess whether the intake of a certain number of olives can meet the health claim associated to olive oil polyphenols (Reg. EU n.432/2012). Our results indicate that the daily intake of only 7 olives, which corresponds to 8 g of edible portion, provide an amount of hydroxytyrosol and derivatives (e.g. oleuropein complex and tyrosol) of 5 mg, according to the health claim of the EU. In view of the results, it could be stated that table olives are an excellent source of bioactive compounds, thus emerging as a promising functional food. (C) 2019 Elsevier B.V. All rights reserved.
C1 Univ Barcelona, Dept Bioquim & Fisiol, Av Joan XXIII 27-31, E-08028 Barcelona, Spain.
   Univ Barcelona, Inst Recerca Nutr & Seguretat Alimentaria INSA UB, Av Joan XXIII 27-31, E-08028 Barcelona, Spain.
C3 University of Barcelona; University of Barcelona
RP Juan, ME; Planas, JM (corresponding author), Univ Barcelona, Dept Bioquim & Fisiol, Fac Farm & Ciencies Alimentacio, Av Joan XXIII 27-31, E-08028 Barcelona, Spain.
EM rociomorenogonzalez@ub.edu; mejuan@ub.edu; jmplanas@ub.edu
RI Moreno Gonzalez, Rocio/AAB-9034-2020; Juan, M Emília/L-9458-2014;
   Planas, Joana M/M-3446-2014
OI Moreno Gonzalez, Rocio/0000-0002-2300-9660; Juan, M
   Emília/0000-0002-8756-2051; Planas, Joana M/0000-0001-7799-5884
FU Ministerio de Economia y Competitividad [AGL2013-41188]; Generalitat de
   Catalunya, Spain [2014SGR1221, 2017SGR945]; Miniesterio de Economia y
   Competitividad [BES-2014-06945]
FX This work was funded by grants AGL2013-41188 from Ministerio de Economia
   y Competitividad and 2014SGR1221 and 2017SGR945 from Generalitat de
   Catalunya, Spain. R.M-G. holds a training grant entitled "Ayuda para
   Contratos Predoctorales para la Formacion de Doctores" from Miniesterio
   de Economia y Competitividad (BES-2014-06945). El Moli de la Creu (La
   Galera, Tarragona, Spain) was the kind supplier of Marfil table olives.
   The authors thank Drs. Isidre Casals, Olga Jauregui and Alberto Adeva
   from CCi-TUB for technical assistance and advice. We also thank Ms.
   Cristina Camps and Ms. Madeleine Bergna for their help at the beginning
   of the set-up of the chromatographic conditions.
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NR 43
TC 37
Z9 38
U1 2
U2 44
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0021-9673
EI 1873-3778
J9 J CHROMATOGR A
JI J. Chromatogr. A
PD JAN 4
PY 2020
VL 1609
AR 460434
DI 10.1016/j.chroma.2019.460434
PG 11
WC Biochemical Research Methods; Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA KG0LK
UT WOS:000509632500023
PM 31416621
DA 2026-05-27
ER

PT J
AU Guo, XC
   Xia, ZY
   Song, MM
   Li, CQ
   Wang, JM
   Kang, WY
AF Guo, Xiuchun
   Xia, Zhaoyang
   Song, Miaomiao
   Li, Changqin
   Wang, Jinmei
   Kang, Wenyi
TI Dynamic Changes of Secondary Metabolites and Antioxidant Activity of
   Ligustrum lucidum During Fruit Growth
SO OPEN CHEMISTRY
LA English
DT Article
DE Ligustri Lucidi Fructus; Dynamic changes; Antioxidative effects;
   Sepctrum-efficacy
ID CHINESE MEDICINAL HERBS; OLEANOLIC ACID; PHENOLIC-COMPOUNDS; SIGNALING
   PATHWAY; IN-VITRO; GLUCOSIDES; MECHANISM; INSULIN; LEAVES; RATS
AB There are a number of secondary metabolites having medicinal values in Ligustri Lucidi Fructus. In this study, the target analytes salidroside, ligustroflavone, specnuezhenide, oleuropein, oleanolic acid and ursolic acid were chosen, aiming to establish a method to investigate the content of six compounds during eight growth stages of Ligustri Lucidi Fructus. Even though the results indicated that the contents of six compounds in different growth periods reached their maximum value, they displayed a downward trend. The antioxidant activity of the analyzed samples also decreased along with the growth period. The relationship between the content of six secondary metabolites and the activity has been elucidated. Hence, this research provides a theoretical basis for guiding efficient use of Ligustri Lucidi Fructus.
C1 [Guo, Xiuchun; Xia, Zhaoyang; Song, Miaomiao; Li, Changqin; Wang, Jinmei; Kang, Wenyi] Henan Univ, Inst Chinese Med Mat, Kaifeng 475004, Peoples R China.
   [Guo, Xiuchun; Li, Changqin; Wang, Jinmei; Kang, Wenyi] Kaifeng Key Lab Funct Components Hlth Food, Kaifeng 475004, Peoples R China.
C3 Henan University
RP Kang, WY (corresponding author), Henan Univ, Inst Chinese Med Mat, Kaifeng 475004, Peoples R China.; Kang, WY (corresponding author), Kaifeng Key Lab Funct Components Hlth Food, Kaifeng 475004, Peoples R China.
EM kangweny@hotmail.com
FU Henan Province University Science and Technology Innovation Team
   [16IRTSTHN019]; Science and Technology Innovation Team of Kaifeng City
   [2016-124]; Key Project in Science and Technology Agency of Kaifeng City
   [1608003]; Kaifeng City Science and Technology Innovation Talent
   [1509010]; National Cooperation Project of Henan province [2015GH12];
   Key Project in Education Agency of Henan Province [16A360008]
FX This work was supported by Henan Province University Science and
   Technology Innovation Team (16IRTSTHN019), Science and Technology
   Innovation Team of Kaifeng City (2016-124), Key Project in Science and
   Technology Agency of Kaifeng City (1608003), Kaifeng City Science and
   Technology Innovation Talent (1509010), National Cooperation Project of
   Henan province (2015GH12), Key Project in Education Agency of Henan
   Province (16A360008).
CR [Anonymous], 2020, THESIS DALIAN MARITI
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NR 36
TC 3
Z9 4
U1 0
U2 16
PU DE GRUYTER POLAND SP ZOO
PI WARSAW
PA BOGUMILA ZUGA 32A STR., 01-811 WARSAW, POLAND
SN 2391-5420
J9 OPEN CHEM
JI Open Chem.
PD JAN
PY 2018
VL 16
IS 1
BP 99
EP 107
DI 10.1515/chem-2018-0012
PG 9
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA FZ5QL
UT WOS:000427650900007
OA gold
DA 2026-05-27
ER

PT J
AU Jin, JY
   Yin, XJ
   Wu, N
   Sun, CH
   Zhao, MJ
   Wang, SH
   Jiang, QW
   Jin, LL
   Zhang, CH
AF Jin, Junyi
   Yin, Xiongjie
   Wu, Nan
   Sun, Chonghao
   Zhao, Mingjing
   Wang, Sihong
   Jiang, Qingwei
   Jin, Lili
   Zhang, Changhao
TI Chemical constituents of Acer tegmentosum Maxim and their chemotaxonomic
   significance
SO BIOCHEMICAL SYSTEMATICS AND ECOLOGY
LA English
DT Article
DE Acer tegmentosum maxim; Chemical constituents; Chemotaxonomy
ID PHENOLIC-COMPOUNDS; ANTIOXIDANT ACTIVITIES; PERIPLOCA-SEPIUM; EXTRACTS;
   ACID; GLYCOSIDES; COUMARIN; LEAVES; ROOTS
AB A phytochemical study of Acer tegmentosum Maxim (the dried stem bark of Acer tegmentosum Maxim) led to the isolation of 28 compounds, including thirteen phenols, five coumarins, four benzoate esters, three tetracyclic triterpenoids, one carbohydrate, one hydrocarbon and one lignan. The structures of these isolated compounds were identified using NMR spectroscopy (1H and 13C) by comparison with previously reported data. To the best of our knowledge, salidroside, 2-(4-Hydroxyphenyl)ethyl beta-D-galactopyranoside, 2-(4-hydroxyphenyl)ethyl 3,4,5-trihydroxybenzoate, 3,3",4,4"-tetrahydroxybiphenyl, (4-methoxyphenyl)acetic acid, daphnetin, 5,6,7-trimethoxycoumarin, 1,2-bis(2-methylheptyl) 1,2-benzenedicarboxylate, 1,4-benzenedicarboxylic acid, periplocoside N and 3,4-dimethoxycinnamyl alcohol were reported from this plant for the first time. Chemotaxonomic significance was discussed.
C1 [Jin, Junyi; Yin, Xiongjie; Wu, Nan; Sun, Chonghao; Zhao, Mingjing; Wang, Sihong; Jin, Lili; Zhang, Changhao] Yanbian Univ, Coll Pharm, Key Lab Nat Med Changbai Mt, Minist Educ, Yanji 133002, Peoples R China.
   [Jiang, Qingwei] Jilin Tianheng Pharmaceut Co Ltd, Meihekou 135000, Peoples R China.
C3 Yanbian University
RP Jin, LL; Zhang, CH (corresponding author), Yanbian Univ, Coll Pharm, Key Lab Nat Med Changbai Mt, Minist Educ, Yanji 133002, Peoples R China.
EM jinlili@ybu.edu.cn; zhangch@ybu.edu.cn
RI si-hong, wang/AAH-6104-2020; Lili, Jin/GQI-2718-2022
OI 尹, 雄杰/0009-0005-1592-784X; Zhang, Changhao/0009-0007-9111-1572
FU National Natural Science Foundation of China [82160741]; Jilin
   Provincial Department of Education [JJKH20230640KJ]
FX This work was supported by the National Natural Science Foundation of
   China [grant number 82160741] and Jilin Provincial Department of
   Education [grant number JJKH20230640KJ] .
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NR 82
TC 3
Z9 3
U1 4
U2 22
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0305-1978
EI 1873-2925
J9 BIOCHEM SYST ECOL
JI Biochem. Syst. Ecol.
PD OCT
PY 2024
VL 116
AR 104882
DI 10.1016/j.bse.2024.104882
EA AUG 2024
PG 7
WC Biochemistry & Molecular Biology; Ecology; Evolutionary Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Environmental Sciences & Ecology;
   Evolutionary Biology
GA D7M1K
UT WOS:001297978500001
DA 2026-05-27
ER

PT J
AU Yang, HQ
   Xue, YX
   Yang, C
   Shen, W
   Fan, Y
   Chen, XZ
AF Yang, Haiquan
   Xue, Yuxiang
   Yang, Cui
   Shen, Wei
   Fan, You
   Chen, Xianzhong
TI Modular Engineering of Tyrosol Production in Escherichia coli
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE tyrosol; module; metabolic engineering; Escherichia coli
ID CANDIDA-ALBICANS BIOFILMS; PATHWAY; DEHYDROGENASE; BIOSYNTHESIS;
   SALIDROSIDE; EXPRESSION
AB In this study, we investigated the effects of the different critical genes in the three modules on tyrosol production in Escherichia coli. Coexpression of the yahK and AR010 genes increased the yield of tyrosol by 10% compared to that of the control. Tyrosol production by E. coli BFPT1 and E. coli BFPA1 was higher by 15.0% and 17.8% than that by the control, respectively, via coordinated expression of key genes from modules 2 and 3. The tyrosol yield of E. coli BFPE2 was 58.3% higher than that of the control (reaching 5.72 mM) when the expression levels of the key genes aroA and tyrA* from module 2 were balanced. The tyrosol yield of E. coli BFPG1 was increased by 52.6% (reaching 5.8 mM) compared to the control via coexpression of modules 1, 2, and 3. This work suggested that microbial production of tyrosol in E. coli has potential for industrial applications.
C1 [Yang, Haiquan; Xue, Yuxiang; Yang, Cui; Shen, Wei; Fan, You; Chen, Xianzhong] Jiangnan Univ, Minist Educ, Key Lab Carbohydrate Chem & Biotechnol, Wuxi 214122, Peoples R China.
   [Yang, Haiquan; Xue, Yuxiang; Yang, Cui; Fan, You; Chen, Xianzhong] Jiangnan Univ, Sch Biotechnol, Wuxi 214122, Peoples R China.
C3 Jiangnan University; Jiangnan University
RP Chen, XZ (corresponding author), Jiangnan Univ, Minist Educ, Key Lab Carbohydrate Chem & Biotechnol, Wuxi 214122, Peoples R China.; Chen, XZ (corresponding author), Jiangnan Univ, Sch Biotechnol, Wuxi 214122, Peoples R China.
EM xzchen@jiangnan.edu.cn
OI Chen, Xianzhong/0000-0003-0695-3382; Yang, Haiquan/0000-0001-6173-8787
FU Priority Academic Program Development of Jiangsu Higher Education
   Institutions; Fundamental Research Funds for the Central Universities
   [JUSRP51611A, JUSRP51504, 2013AA102101-5]; 111 Project [1112-06];
   Postgraduate Education Research and Practice Project of Jiangnan
   University [YJSJG2017004]
FX This study was funded by the Priority Academic Program Development of
   Jiangsu Higher Education Institutions, the Fundamental Research Funds
   for the Central Universities (JUSRP51611A and JUSRP51504),
   2013AA102101-5 (863 program), the 111 Project (no. 1112-06), and
   Postgraduate Education Research and Practice Project of Jiangnan
   University (YJSJG2017004).
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NR 33
TC 27
Z9 33
U1 1
U2 93
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD APR 10
PY 2019
VL 67
IS 14
BP 3900
EP 3908
DI 10.1021/acs.jafc.9b00227
PG 9
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA HT7UA
UT WOS:000464768700008
PM 30873833
DA 2026-05-27
ER

PT J
AU Wang, K
   Wang, L
   Zhao, GJ
   Liu, Y
   Wang, FC
   Song, H
   Sun, Y
   Zhou, ZS
   Lu, XC
   Hu, HB
   Cui, HT
AF Wang, Kun
   Wang, Li
   Zhao, Guojing
   Liu, Yong
   Wang, Fengchan
   Song, Huan
   Sun, Yin
   Zhou, Zhaoshan
   Lu, Xuechao
   Hu, Haibo
   Cui, Huantian
TI Mechanistic study of salidroside on ovalbumin-induced asthmatic model
   mice based on untargeted metabolomics analysis
SO FOOD & FUNCTION
LA English
DT Article
ID ALLERGIC AIRWAY INFLAMMATION; ACETYL-L-CARNITINE; OXIDATIVE STRESS;
   SERUM-LEVELS; EXPRESSION; PATHOGENESIS; PREVENTION; INJURY; ACID; LUNG
AB Salidroside (SAL) is a natural component derived from Rhodiola rosea and is well known for its wide range of biological activities such as its anti-inflammatory and anti-oxidative properties. However, its effects and mechanisms of action related to asthma have not been well explored yet. Recent studies have found that changes in host metabolism are closely related to the progression of asthma. Many natural components can ameliorate asthma by affecting host metabolism. The use of untargeted metabolomics can allow for a better understanding of the metabolic regulatory mechanisms of herbs on asthma. This study aimed to demonstrate the anti-asthmatic effects and metabolic regulatory mechanisms of SAL. In this study, the therapeutic effects of SAL on asthmatic mice were tested at first. Secondly, the effects of SAL on the airway inflammatory reaction, oxidative stress, and airway remodeling were investigated. Finally, untargeted metabolomics analysis was used to explore the influence of SAL on lung metabolites. The results showed that SAL had a significant therapeutic effect on asthmatic model mice. Moreover, SAL treatment lowered interleukin (IL)-4, IL-5, and IL-13 levels but elevated interferon gamma (IFN-gamma) and IL-10 levels in bronchoalveolar lavage fluid (BALF). Additionally, it also increased superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities and decreased methane dicarboxylic aldehyde (MDA) levels in the lungs. Besides, SAL-treated mice showed decreased expression of smooth muscle actin (alpha-SMA), matrix metallopeptidase 2 (MMP2), matrix metallopeptidase 9 (MMP9), and transforming growth factor-beta 1 (TGF-beta 1) in the lung. Untargeted metabolomics analysis showed 31 metabolites in the lungs that were influenced by SAL. These metabolites were related to pyrimidine metabolism, steroid hormone biosynthesis, and tricarboxylic acid (TCA) cycle. In conclusion, SAL treatment can reduce the inflammatory response, oxidative stress, and airway remodeling in asthmatic model mice. The mechanism of SAL in the treatment of asthma may be related to the regulation of pyrimidine metabolism, steroid hormone biosynthesis, and the TCA cycle. Further studies can be carried out using targeted metabolomics and in vitro models to deeply elucidate the anti-inflammatory and anti-oxidative mechanisms of SAL on asthma based on regulating metabolism.
C1 [Wang, Kun; Wang, Li; Zhao, Guojing; Liu, Yong; Wang, Fengchan; Song, Huan; Sun, Yin; Zhou, Zhaoshan; Lu, Xuechao; Hu, Haibo] Qingdao Univ, Qingdao Tradit Chinese Med Hosp, Qingdao Hiser Hosp, Qingdao, Peoples R China.
   [Cui, Huantian] Shandong Univ, Sch Life Sci, Shandong Prov Key Lab Anim Cell & Dev Biol, Jinan, Shandong, Peoples R China.
C3 Qingdao University; Shandong University
RP Lu, XC; Hu, HB (corresponding author), Qingdao Univ, Qingdao Tradit Chinese Med Hosp, Qingdao Hiser Hosp, Qingdao, Peoples R China.; Cui, HT (corresponding author), Shandong Univ, Sch Life Sci, Shandong Prov Key Lab Anim Cell & Dev Biol, Jinan, Shandong, Peoples R China.
EM hospitalbreathing@163.com; iamhhb1982@163.com; 1762316411@qq.com
RI Cui, Huantian/AAS-4283-2021
FU Qingdao Health Science and Technology Project; Shandong Provincial TCM
   Science and Technology Development Plan Project; TCM Science and
   Technology Project of Shandong Province;  [2020-WJZD053];  [2019-0596]; 
   [A-1244]
FX This work was supported by the Qingdao Health Science and Technology
   Project (2020-WJZD053) and the Shandong Provincial TCM Science and
   Technology Development Plan Project (2019-0596) and TCM Science and
   Technology Project of Shandong Province (A-1244).
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NR 47
TC 16
Z9 19
U1 4
U2 45
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD JAN 3
PY 2023
VL 14
IS 1
BP 413
EP 426
DI 10.1039/d2fo02225g
EA NOV 2022
PG 14
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA 7I4QQ
UT WOS:000897017000001
PM 36515134
DA 2026-05-27
ER

PT J
AU Chen, G
   Li, J
   Zhang, SJ
   Song, CH
   Li, GL
   Sun, ZW
   Suo, YR
   You, JM
AF Chen, Guang
   Li, Jun
   Zhang, Shijuan
   Song, Cuihua
   Li, Guoliang
   Sun, Zhiwei
   Suo, Yourui
   You, Jinmao
TI A sensitive and efficient method to systematically detect two biophenols
   in medicinal herb, herbal products and rat plasma based on thorough
   study of derivatization and its convenient application to
   pharmacokinetics with semi-automated device
SO JOURNAL OF CHROMATOGRAPHY A
LA English
DT Article
DE Biophenol; Medicinal herb; Derivatization; Multivariate optimization;
   Artificial neural network; Pharmacokinetics
ID PERFORMANCE LIQUID-CHROMATOGRAPHY; ARTIFICIAL NEURAL-NETWORKS;
   QUANTITATIVE-DETERMINATION; RHODIOLA-CRENULATA; GENETIC ALGORITHMS;
   MASS-SPECTROMETRY; SALIDROSIDE; FLUORESCENCE; TYROSOL; HPLC
AB A sensitive and efficient method using a semi-automated pretreatment device, pre-column derivatization, multivariate optimization and high performance liquid chromatography with fluorescence and mass spectrometric detection was developed and validated for the systematic determination of two biophenols in four herb-related samples (medicinal herb; herbal products in tablet, capsule and oral liquid forms) and plasma samples after oral administration to rat. Only micro-sampling of 20 mu L blood was needed for the analysis, and the pretreatment procedure including blood collection, derivatization by 10-ethyl-acridine-3-sulfonyl chloride (EASC) and injection to the sampling vials was efficiently finished in 10 min with no cumbersome and complicated operation. The novel application of artificial neural network (ANN) coupled with genetic algorithm (GA) to optimization of derivatization condition was executed and compared with the classical response surface methodology (RSM). The optimal condition for derivatization was validated by multi-criteria and nonparametric tests and used successfully to achieve the higher sensitivity (limit of detection: 0.6 and 0.8 ng/mL). The limit of reactant concentration (LORC) was put forward for derivatization method for the first time, and the lower values (2.0-2.7 ng/mL) provided the guarantee for the trace detection with the micro samples (<50 mu L) required. The results of validation including selectivity, sensitivity, linearity, accuracy, precision, recovery, matrix effect and stability demonstrated the advantages of this method. The pharmacokinetic study of major bioactive components salidroside and p-tyrosol in herb Rhodiola crenulata and its products was more conveniently performed in 25 min. The established method could be the sensitive and efficient alternative method for the systematic detection of bioactive components in series of drug carriers from raw herb to herbal products and to blood in medical research. And the approaches of the thorough study played the guiding role in seeking a novel analytical method. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Chen, Guang; Zhang, Shijuan; Li, Guoliang; Suo, Yourui; You, Jinmao] Chinese Acad Sci, NW Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining 810001, Peoples R China.
   [Chen, Guang; Zhang, Shijuan; Li, Guoliang] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China.
   [Chen, Guang; Li, Jun; Song, Cuihua; Sun, Zhiwei; You, Jinmao] Qufu Normal Univ, Key Lab Life Organ Anal, Qufu 273165, Shandong, Peoples R China.
   [Chen, Guang; Li, Jun; Song, Cuihua; Sun, Zhiwei; You, Jinmao] Qufu Normal Univ, Key Lab Pharmaceut Intermediates & Anal Nat Med, Qufu 273165, Shandong, Peoples R China.
C3 Chinese Academy of Sciences; Chinese Academy of Sciences; University of
   Chinese Academy of Sciences, CAS; Qufu Normal University; Qufu Normal
   University
RP You, JM (corresponding author), Chinese Acad Sci, NW Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining 810001, Peoples R China.
EM jmyou6304@163.com
OI Sun, Zhiwei/0000-0003-2171-6035
FU Chinese Academy of Sciences [328]; Key Laboratory of Bioorganic Analysis
   Shandong Province; Key Laboratory of Pharmaceutical Intermediates and
   Analysis of Natural Medicine Shandong Province; Qufu Normal University
   [XJ201102]; undergraduate research-training programs [2011A026]
FX This work was supported by the 100 Talents Program of the Chinese
   Academy of Sciences (no. 328), Key Laboratory of Bioorganic Analysis
   Shandong Province, Key Laboratory of Pharmaceutical Intermediates and
   Analysis of Natural Medicine Shandong Province, the research project
   fund (XJ201102) of Qufu Normal University, and the undergraduate
   research-training programs (2011A026).
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NR 41
TC 6
Z9 7
U1 1
U2 41
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0021-9673
EI 1873-3778
J9 J CHROMATOGR A
JI J. Chromatogr. A
PD AUG 3
PY 2012
VL 1249
BP 190
EP 200
DI 10.1016/j.chroma.2012.06.027
PG 11
WC Biochemical Research Methods; Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 979KK
UT WOS:000306818700020
PM 22749364
DA 2026-05-27
ER

PT J
AU Molina, CN
   Gasparre, N
   Mañes, J
   Scanlon, MG
AF Molina, Carla N.
   Gasparre, Nicola
   Manes, Jordi
   Scanlon, Martin G.
TI Development of high-protein functional crackers enriched with
   adaptogenic compounds
SO LWT-FOOD SCIENCE AND TECHNOLOGY
LA English
DT Article
DE Cracker; Functional food; Adaptogen; Eleutherococcus senticosus;
   Rhodiola rosea
ID RHODIOLA-ROSEA; PULSE FLOURS
AB Consumers increasingly seek convenient, healthy snacks with innovative flavors and strong nutritional profiles. Traditional crackers are versatile but low in protein. Adding faba bean protein isolate offers a plant-based way to enhance protein content. Incorporating powdered roots from Rhodiola rosea (RR) and Eleutherococcus senticosus (ES) can further provide functional health benefits. This study aimed to develop high-protein crackers enriched with root powders and examined their impact on dough rheology, pasting properties, cracker texture, and bioactive compound stability after processing. RR and ES powders significantly reduced both G ' and G '' moduli of the dough and increased apparent peak and final viscosity. Cracker hardness and distance to break decreased with root addition. Quantification of bioactive compounds confirmed that higher RR and ES levels led to increased salidroside, tyrosol, rosarin and eleutheroside E contents. These findings highlight the functional and structural advantages of incorporating Rhodiola rosea and Eleutherococcus senticosus into cracker formulations.
C1 [Molina, Carla N.; Gasparre, Nicola; Scanlon, Martin G.] Univ Manitoba, Dept Food & Human Nutr Sci, Winnipeg, MB, Canada.
   [Molina, Carla N.; Manes, Jordi] Univ Valencia, Fac Pharm, Dept Publ Hlth, Burjassot, Spain.
C3 University of Manitoba; University of Valencia
RP Scanlon, MG (corresponding author), Univ Manitoba, Dept Food & Human Nutr Sci, Winnipeg, MB, Canada.
EM Martin.Scanlon@umanitoba.ca
RI Mañes, Jordi/K-3709-2014; Gasparre, Nicola/GPS-4429-2022; Scanlon,
   Martin/LKL-9024-2024
OI Molina, Carla N/0000-0001-6813-3086; Gasparre,
   Nicola/0000-0001-5687-0249; 
FU NSERC Discovery Research Program [RGPIN-2024-05467]
FX This study was supported by the NSERC Discovery Research Program
   (RGPIN-2024-05467) .
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NR 40
TC 1
Z9 1
U1 6
U2 11
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0023-6438
EI 1096-1127
J9 LWT-FOOD SCI TECHNOL
JI LWT-Food Sci. Technol.
PD AUG 15
PY 2025
VL 230
AR 118257
DI 10.1016/j.lwt.2025.118257
EA AUG 2025
PG 8
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 5VY2D
UT WOS:001545619700003
OA gold
DA 2026-05-27
ER

PT J
AU Wu, ZH
   Wang, YH
   Gao, R
   Chen, JR
   Chen, YF
   Li, MX
   Gao, Y
AF Wu, Zhenhui
   Wang, Yihao
   Gao, Rong
   Chen, Junru
   Chen, Yingfan
   Li, Maoxing
   Gao, Yue
TI Potential therapeutic effects of traditional Chinese medicine in acute
   mountain sickness: pathogenesis, mechanisms and future directions
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE traditional Chinese medicine; acute mountain sickness; hypobaric
   hypoxia; pathogenesis; mechanism
ID ALTITUDE CEREBRAL EDEMA; SUPPRESSING OXIDATIVE STRESS; ACUTE HYPOBARIC
   HYPOXIA; INFLAMMATION; EXTRACT; MODEL
AB Background and objectives Acute mountain sickness (AMS) is a pathology with different symptoms in which the organism is not adapted to the environment that occurs under the special environment of high altitude. Its main mechanism is the organism's tissue damage caused by acute hypobaric hypoxia. Traditional Chinese medicine (TCM) theory focuses on the holistic concept. TCM has made remarkable achievements in the treatment of many mountain sicknesses. This review outlines the pathogenesis of AMS in modern and traditional medicine, the progress of animal models of AMS, and summarizes the therapeutic effects of TCM on AMS.
   Methods Using the keywords "traditional Chinese medicine," "herbal medicine," "acute mountain sickness," "high-altitude pulmonary edema," "high-altitude cerebral edema," "acute hypobaric hypoxia," and "high-altitude," all relevant TCM literature published up to November 2023 were collected from Scopus, Web of Science, PubMed, and China National Knowledge Infrastructure databases, and the key information was analyzed.
   Results We systematically summarised the effects of acute hypobaric hypoxia on the tissues of the organism, the study of the methodology for the establishment of an animal model of AMS, and retrieved 18 proprietary Chinese medicines for the clinical treatment of AMS. The therapeutic principle of medicines is mainly invigorating qi, activating blood and removing stasis. The components of botanical drugs mainly include salidroside, ginsenoside Rg1, and tetrahydrocurcumin. The mechanism of action of TCM in the treatment of AMS is mainly through the regulation of HIF-1 alpha/NF-kappa B signaling pathway, inhibition of inflammatory response and oxidative stress, and enhancement of energy metabolism.
   Conclusion The main pathogenesis of AMS is unclear. Still, TCM formulas and components have been used to treat AMS through multifaceted interventions, such as compound danshen drip pills, Huangqi Baihe granules, salidroside, and ginsenoside Rg1. These components generally exert anti-AMS pharmacological effects by inhibiting the expression of VEGF, concentration of MDA and pro-inflammatory factors, down-regulating NF-kappa B/NLRP3 pathway, and promoting SOD and Na + -K + -ATPase activities, which attenuates acute hypobaric hypoxia-induced tissue injury. This review comprehensively analyses the application of TCM in AMS and makes suggestions for more in-depth studies in the future, aiming to provide some ideas and insights for subsequent studies.
C1 [Wu, Zhenhui; Gao, Yue] Jiangxi Univ Chinese Med, Sch Pharm, Nanchang, Peoples R China.
   [Wu, Zhenhui] Jiangxi Univ Chinese Med, Dept Hematol, Affiliated Hosp, Nanchang, Peoples R China.
   [Wang, Yihao; Gao, Rong; Chen, Junru; Li, Maoxing; Gao, Yue] Beijing Inst Radiat Med, Beijing, Peoples R China.
   [Chen, Yingfan] Sixth Med Ctr Chinese Peoples Liberat Army Gen Hos, Dept Tradit Chinese Med, Beijing, Peoples R China.
C3 Jiangxi University of Traditional Chinese Medicine; Jiangxi University
   of Traditional Chinese Medicine; Academy of Military Medical Sciences -
   China
RP Gao, Y (corresponding author), Jiangxi Univ Chinese Med, Sch Pharm, Nanchang, Peoples R China.; Li, MX; Gao, Y (corresponding author), Beijing Inst Radiat Med, Beijing, Peoples R China.
EM gaoyue@bmi.ac.cn; limaox2020@aliyun.com
RI 伍, 振辉/HTS-1374-2023; Chen, Junru/KHC-6427-2024
FU National Natural Science Foundation of China10.13039/501100001809
FX No Statement Available
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NR 127
TC 16
Z9 21
U1 16
U2 64
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD JUN 4
PY 2024
VL 15
AR 1393209
DI 10.3389/fphar.2024.1393209
PG 17
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA UM4L6
UT WOS:001248463500001
PM 38895636
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Feng, Z
   Yang, Y
   Shi, CX
   Liu, AQ
   Wu, CL
   Liu, WQ
   Yu, SX
   Yu, HD
   Zuo, ZF
   Liu, XZ
AF Feng, Zhen
   Yang, Yang
   Shi, Cai-xing
   Liu, An-Qi
   Wu, Chuan-Ling
   Liu, Wen-Qiang
   Yu, Sheng-Xue
   Yu, Hong -Dan
   Zuo, Zhong-Fu
   Liu, Xue-Zheng
TI Salidroside ameliorates diabetic retinopathy and Müller cell
   inflammation via the PI3K/Akt/GSK-3β/NF-kB pathway
SO MOLECULAR VISION
LA English
DT Article
ID FACTOR-KAPPA-B; BREAST-CANCER; MULLER CELL; ENDOTHELIAL-CELLS;
   ACTIVATION; CYTOKINES; PROTECTS; SYNTHASE; BETA; RATS
AB Purpose: To determine whether salidroside (SAL) modulates inflammatory cytokines in rat retinal Muller cells (rMC-1) in a hyperglycemic environment by investigating the anti-inflammatory mechanisms of SAL in vitro and in vivo. Methods: A streptozotocin (STZ)-induced diabetic rat model was established to examine the effects of SAL using hematoxylin and eosin (H&E) staining and immunohistochemistry. rMC-1 cells were grown in 50 mM of high -glucose medium. These simulated diabetic conditions were used to evaluate the anti-inflammatory effects of SAL using a Cell Counting Kit -8 (CCK-8) assay, immunofluorescence staining, western blotting, and real-time polymerase chain reaction (qRT-PCR). H&E staining was used to analyze the number of ganglion cells in the retina. rMC-1 lysates were processed for qRT-PCR to measure the steady-state mRNA expression levels of inflammatory markers, such as interleukin 6 (IL -6), interleukin 10 (IL -10), and interleukin 1 beta (IL-1 beta). Western blot analysis and immunofluorescence staining were performed to determine the levels of these inflammatory markers. Results: Our study showed that SAL reversed retinal ganglion cell loss and attenuated nuclear factor kappa B (NF-kB) p65 translocation to the nucleus in STZ-induced diabetic rats. Incubating rMC-1 in different concentrations of SAL for 24 to 48 h affected cell viability. Furthermore, SAL treatment significantly decreased the protein levels of IL -6, TNF-alpha, and IL-1 beta compared with those in cells cultured in high glucose (HG). The mRNA expression levels of IL -6 and IL-1 beta were considerably reduced after SAL treatment, whereas the mRNA expression levels of IL -10 were significantly increased. Interestingly, the beneficial effects of SAL on HG -treated rMC-1 cells were abolished by the PI3K inhibitor LY294002. Conclusions: These results indicate that SAL treatment reduces cytokine activation in cultured rMC-1. Furthermore, SAL prevents diabetic retinopathy (DR), in part, by modulating the PI3K/Akt/GSK-3 beta/NF-kB pathway to inhibit Muller cell activation. Thus, SAL is expected to be a potential agent for ameliorating the progression of DR.
C1 [Feng, Zhen; Yang, Yang; Liu, An-Qi; Liu, Wen-Qiang; Yu, Sheng-Xue; Yu, Hong -Dan; Zuo, Zhong-Fu; Liu, Xue-Zheng] Jinzhou Med Univ, Dept Anat Histol & Embryol, Liaoning Key Lab Diabet Cognit & Percept Dysfunct, Jinzhou, Liaoning, Peoples R China.
   [Feng, Zhen; Yang, Yang] Zhejiang Changzheng Vocat Tech Coll, Shenyang, Peoples R China.
   [Shi, Cai-xing] China Med Univ, Shenyang, Peoples R China.
   [Wu, Chuan-Ling] Zhejiang Ind Vocat & Tech Coll, Shaoxing, Zhejiang, Peoples R China.
   [Zuo, Zhong-Fu] Guangxi Med Univ, Dept Anat Histol & Embryol, Postdoctoral Res Stn, Nanning, Guangxi, Peoples R China.
   [Liu, Xue-Zheng] Jinzhou Med Univ, Dept Anat Histol & Embryol, Jinzhou 121000, Liaoning, Peoples R China.
C3 Jinzhou Medical University; China Medical University; Guangxi Medical
   University; Jinzhou Medical University
RP Liu, XZ (corresponding author), Jinzhou Med Univ, Dept Anat Histol & Embryol, Jinzhou 121000, Liaoning, Peoples R China.
EM 164352674@qq.com; 951564552@qq.com
RI /AAS-9154-2020; Liu, Anqi/HHS-8668-2022
FU Foundation of Education Department of Liaoning Province [LJKMZ20221241,
   951564552, 164352674]
FX The author (s) disclosed receipt of the following financial support for
   the research, authorship, and publication of this article: This work was
   supported by the Foundation of Education Department of Liaoning Province
   (N0s. LJKMZ20221241) . Dr. Xue-Zheng Liu (951564552@ qq.com ) and Dr.
   Zhong-Fu Zuo (164352674@qq.com ) are co-corresponding authors for this
   paper.
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NR 45
TC 5
Z9 6
U1 0
U2 3
PU MOLECULAR VISION
PI ATLANTA
PA C/O JEFF BOATRIGHT, LAB B, 5500 EMORY EYE CENTER, 1327 CLIFTON RD, N E,
   ATLANTA, GA 30322 USA
SN 1090-0535
J9 MOL VIS
JI Mol. Vis.
PD FEB 10
PY 2024
VL 30
BP 1
EP 16
PG 16
WC Biochemistry & Molecular Biology; Ophthalmology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Ophthalmology
GA IS1M6
UT WOS:001168229700001
PM 39588324
DA 2026-05-27
ER

PT J
AU Cui, WX
   Ruan, X
   Li, ZH
   Zhang, H
   Liu, B
   Wang, Q
AF Cui, Wenxia
   Ruan, Xiao
   Li, Zhaohui
   Zhang, Huan
   Liu, Ben
   Wang, Qiang
TI Optimization of process parameters of extraction of lotaustralin from
   the roots of Rhodiola rosea L using supercritical CO2
   plus modifier
SO TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY
LA English
DT Article
DE Supercritical carbon dioxide extraction; response surface methodology;
   Rhodiola rosea L; lotaustralin modifier; high-performance liquid
   chromatography
ID CARBON-DIOXIDE EXTRACTION; SALIDROSIDE; VOLATILES; MICE
AB Lotaustralin from the root of Rhodiola rosea L was extracted using supercritical carbon dioxide with methanol as modifier. Response surface methodology using Box-Behnken experimental design was utilized to explore parameters for supercritical carbon dioxide extraction. The effects of various values of temperatures (50-70 degrees C), pressures (200-400 bar), and percentages of methanol modifier (80%-100%) on the extraction yields of lotaustralin were evaluated. Extract identification was performed using high-performance liquid chromatography. The experimental data obtained were fitted to second-order polynomial equations and assessed using analysis of variance. The highest yields predicted from the experiments were 2.05 g kg(1) lotaustralin at the optimal values, i.e. temperature 65 degrees C, pressure 316 bar, 88% methanol modifier at a flow rate of 0.4 mL min(1), and dynamic extraction time 90 min.
C1 [Cui, Wenxia; Ruan, Xiao; Zhang, Huan; Liu, Ben; Wang, Qiang] Zhejiang Univ, Ningbo Inst Technol, Dept Chem & Biol Engn, Ningbo, Zhejiang, Peoples R China.
   [Li, Zhaohui] Zhejiang Pharmaceut Coll, Dept Tradit Chinese Med, Ningbo, Zhejiang, Peoples R China.
C3 Zhejiang University
RP Wang, Q (corresponding author), Zhejiang Univ, Ningbo Inst Technol, Dept Chem & Biol Engn, Ningbo, Zhejiang, Peoples R China.
EM wangqiangsky@263.net
RI Zhang, Huan/OXB-2365-2025
FU Natural Science Foundation of China (NSFC) [30470330]; Department of
   Science and Technology of Ningbo [2014C10021]; Natural Science
   Foundation of Zhejiang Province [Y2110691]
FX The authors are grateful to the Natural Science Foundation of China
   (NSFC) [grant number 30470330]; Department of Science and Technology of
   Ningbo [grant number 2014C10021]; Natural Science Foundation of Zhejiang
   Province [grant number Y2110691] for the financial support of the work.
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NR 20
TC 2
Z9 3
U1 1
U2 15
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0277-2248
EI 1029-0486
J9 TOXICOL ENVIRON CHEM
JI Toxicol Environ. Chem.
PY 2016
VL 98
IS 7
BP 727
EP 735
DI 10.1080/02772248.2015.1137100
PG 9
WC Environmental Sciences; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Toxicology
GA DR1XW
UT WOS:000379699200004
DA 2026-05-27
ER

PT J
AU György, Z
   Fjelldal, E
   Ladányi, M
   Aspholm, PE
   Pedryc, A
AF Gyoergy, Zsuzsanna
   Fjelldal, Erling
   Ladanyi, Marta
   Aspholm, Paul Eric
   Pedryc, Andrzej
TI Genetic diversity of roseroot (Rhodiola rosea) in North-Norway
SO BIOCHEMICAL SYSTEMATICS AND ECOLOGY
LA English
DT Article
DE Rhodiola rosea; Molecular markers; ISSR; Genetic diversity; Rosavins;
   Salidroside
ID PLATEAU
AB Roseroot (Rhodiola rosea L.), an adaptogenic herb, has received increased attention in the last years. Genetic diversity of roseroot in Northern-Norway was studied with ISSR markers. Plants were collected in Finnmark County, Norway at 10 habitats. Using 8 ISSR primers 53 DNA fragments were generated and 92.45% of those were found to be polymorphic, indicating high genetic variability at the species level (Shannon index = 0,4122). Lower level of diversity was detected at the population level (Shannon-index ranged from 0.21 to 0.36). Generated UPGMA dendrogram revealed 2 groups. An attempt was made to connect molecular marker data to the pharmacologically important glycoside content of the plants. The habitat with the lowest glycoside content separated from the others on the dendrogram, but no ISSR marker could be assigned to this trait. AMOVA showed that molecular variance has no effect on the glycoside content, it is only effected by environmental factors. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Gyoergy, Zsuzsanna; Pedryc, Andrzej] Corvinus Univ Budapest, Dept Genet & Plant Breeding, H-1518 Budapest, Hungary.
   [Ladanyi, Marta] Corvinus Univ Budapest, Dept Math & Informat, H-1518 Budapest, Hungary.
C3 Corvinus University Budapest; Corvinus University Budapest
RP György, Z (corresponding author), Corvinus Univ Budapest, Dept Genet & Plant Breeding, POB 53, H-1518 Budapest, Hungary.
EM zsuzsanna.gyorgy@uni-corvinus.hu; erling.fjelldal@bioforsk.no;
   marta.ladanyi@uni-corvinus.hu; paul.eric.aspholm@bioforsk.no;
   andrzej.pedryc@uni-corvius.hu
RI Ladanyi, Marta/AAX-9067-2021; György, Zsuzsanna/L-7105-2016
OI Ladanyi, Marta/0000-0003-3114-8289; György,
   Zsuzsanna/0000-0002-7803-5487
FU Hungarian Scientific Research Fund [OTKA 83728]; National Development
   Agency [TAMOP-4.2.1/B-09/1/KMR-2010-0005, TAMOP-4.2.2/B-10/1-2010-0023]
FX This study was financed by Hungarian Scientific Research Fund (OTKA
   83728), and the National Development Agency
   (TAMOP-4.2.1/B-09/1/KMR-2010-0005 and TAMOP-4.2.2/B-10/1-2010-0023).
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NR 21
TC 4
Z9 4
U1 1
U2 37
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0305-1978
EI 1873-2925
J9 BIOCHEM SYST ECOL
JI Biochem. Syst. Ecol.
PD OCT
PY 2013
VL 50
BP 361
EP 367
DI 10.1016/j.bse.2013.05.009
PG 7
WC Biochemistry & Molecular Biology; Ecology; Evolutionary Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Environmental Sciences & Ecology;
   Evolutionary Biology
GA 233VM
UT WOS:000325597600053
DA 2026-05-27
ER

PT J
AU Chabane, FA
   Tamendjari, A
   Rovellini, P
   Romero, C
   Medina, E
AF Chabane, F. Ait
   Tamendjari, A.
   Rovellini, P.
   Romero, C.
   Medina, E.
TI Chemical parameters and antioxidant activity of turning color
   natural-style table olives of the Sigoise cultivar
SO GRASAS Y ACEITES
LA English
DT Article
DE Antioxidant activity; Polyphenols; Sigoise cultivar; Sugars; Tocopherols
ID LACTIC-ACID BACTERIA; OLEUROPEIN HYDROLYSIS; GREEN OLIVES; FERMENTATION;
   L.; TOCOPHEROL; VARIETIES; PHENOLICS; PROFILE; YEASTS
AB A chemical characterization of turning color table olives of the Sigoise variety was made through their processing as natural-style. Polyphenols, sugars, tocopherols, fatty acids, and antioxidant activity in the olives were monitored throughout the elaboration process. Oleuropein, salidroside, hydroxytyrosol 4-glucoside, rutin, ligustroside and verbascoside showed a decrease of 16.90-83.34%, while hydroxytyrosol increased during the first months of brining. Glucose was consumed by 90% due to the metabolism of the fermentative microbiota. The tocopherol content remained stable during the process and only the alpha-tocopherol decreased. The fatty acids were not affected. The loss in antioxidant compounds resulted in a decrease in the percentage of DPPH radical inhibition from 75.91% in the raw fruit to 44.20% after 150 days of brining. Therefore, the turning color natural table olives of the Sigoise variety are a good source of bioactive compounds.
C1 [Chabane, F. Ait; Tamendjari, A.] Univ Bejaia, Fac Sci Nat & Vie, Lab Biochim Appl, Bejaia 06000, Algeria.
   [Rovellini, P.] INNOVHUB SSI Azienda Speciale Camera Commercio Mi, Via Giuseppe Colombo 79, I-20133 Milan, Italy.
   [Romero, C.; Medina, E.] IG CSIC, Food Biotechnol Dept, Inst Grasa, Crta Utrera Km 1,Ed 46, Seville 41013, Spain.
C3 Universite de Bejaia; Consejo Superior de Investigaciones Cientificas
   (CSIC); CSIC - Instituto de la Grasa (IG)
RP Medina, E (corresponding author), IG CSIC, Food Biotechnol Dept, Inst Grasa, Crta Utrera Km 1,Ed 46, Seville 41013, Spain.
EM emedina@ig.csic.es
RI ; Romero, Concepcion/F-2268-2016; Eduardo, Medina/D-3296-2014
OI Ait Chabane, Fadila/0000-0003-0708-0974; Romero,
   Concepcion/0000-0003-1885-1770; Eduardo, Medina/0000-0002-9978-4524
FU Algerian Ministry of Higher Education and Scientific Research; Spanish
   Government [RTI2018-093994-J-I00]; Spanish Government (AEI/FEDER);
   Spanish Government (UE); Spanish Government (Ramon y Cajal Programme )
   [RyC2018-024752-I]
FX We want to thank the Algerian Ministry of Higher Education and
   Scientific Research for sponsoring this work. The authors are grateful
   to the staff of the company KHODJA & CO Seddouk (Bejaia, Algeria) for
   providing the samples. This work was also supported by the Spanish
   Government (Project RTI2018-093994-J-I00, AEI/FEDER, UE and Ramon y
   Cajal Programme RyC2018-024752-I).
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NR 33
TC 3
Z9 3
U1 0
U2 28
PU CONSEJO SUPERIOR INVESTIGACIONES CIENTIFICAS-CSIC
PI MADRID
PA Editorial CSIC, C/VITRUVIO 8, 28006 MADRID, SPAIN
SN 0017-3495
EI 1988-4214
J9 GRASAS ACEITES
JI Grasas Aceites
PD JUL-SEP
PY 2021
VL 72
IS 3
AR e419
DI 10.3989/gya.0559201
PG 11
WC Chemistry, Applied; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Food Science & Technology
GA WM7GM
UT WOS:000711249600001
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Shi, Q
   Chen, HB
   Wu, Y
   Tong, P
   Gao, JY
AF Shi, Qiang
   Chen, Hongbing
   Wu, Yong
   Tong, Ping
   Gao, Jinyan
TI Integrative analysis of transcriptomic and metabolomic profiles uncovers
   health-promoting mechanisms of ovotransferrin in
   Caenorhabditis elegans
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Caenorhabditis elegans; Ovotransferrin; Physiology; Transcriptomics;
   Metabolomics
ID LIFE-SPAN; ANTIOXIDANT; LACTOFERRIN; STRESS; COPPER
AB Ovotransferrin (OVT) is a natural protein with various nutritional and biological benefits. However, further research is required to explore its effects and underlying mechanisms. To bridge this gap, conventional physiological methods with modern multi-omics approaches were employed to investigate the functional effects, metabolic targets and potential mechanisms of OVT, using Caenorhabditis elegans (C. elegans) as the model. Results revealed that OVT could improve oxidative stress and prolong lifespan in C. elegans by enhancing the activities of antioxidant enzymes and lowering levels of malondialdehyde, lipofuscin, and reactive oxygen species. Integrative analysis indicated that the upregulation of genes encoding Cytochrome P450 and sod-2, and the increase in polyunsaturated fatty acids and salidroside should be closely associated with its effects in C. elegans. Moreover, enhanced intestinal mitochondria activity was observed in SJ4143 mutants. These results suggested that the action mechanisms of OVT in health promotion involved regulating lipid metabolism and boosting energy metabolism.
C1 [Shi, Qiang; Chen, Hongbing; Tong, Ping] Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Peoples R China.
   [Shi, Qiang; Gao, Jinyan] Nanchang Univ, Coll Food Sci & Technol, Nanchang 330031, Peoples R China.
   [Chen, Hongbing; Wu, Yong] Nanchang Univ, Jiangxi OAI Joint Res Inst, Nanchang 330047, Jiangxi, Peoples R China.
   [Tong, Ping] Nanchang Univ, State Key Lab Food Sci & Technol, 235 Nanjing Eastern Rd, Nanchang 330047, Peoples R China.
   [Gao, Jinyan] Nanchang Univ, Coll Food Sci & Technol, 235 Nanjing Eastern Rd, Nanchang 330047, Peoples R China.
C3 Nanchang University; Nanchang University; Nanchang University; Nanchang
   University; Nanchang University
RP Tong, P (corresponding author), Nanchang Univ, State Key Lab Food Sci & Technol, 235 Nanjing Eastern Rd, Nanchang 330047, Peoples R China.; Gao, JY (corresponding author), Nanchang Univ, Coll Food Sci & Technol, 235 Nanjing Eastern Rd, Nanchang 330047, Peoples R China.
EM tongping@ncu.edu.cn; gaojy2013@ncu.edu.cn
OI Tong, Ping/0000-0002-0298-6411
FU National Natural Science Foundation Grant of China [32072339]; Central
   Government Guide Local Special Found Project for Scientific and
   Technological Development of Jiangxi Province [20221ZDD02001]
FX Funding This work is supported by the National Natural Science
   Foundation Grant of China (32072339) and the Central Government Guide
   Local Special Found Project for Scientific and Technological Development
   of Jiangxi Province (20221ZDD02001) .
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EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD AUG
PY 2023
VL 107
AR 105660
DI 10.1016/j.jff.2023.105660
EA JUL 2023
PG 11
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA M3MD1
UT WOS:001029244100001
OA gold
DA 2026-05-27
ER

PT J
AU Su, JQ
   Zhou, F
   Wu, S
   Tong, ZY
AF Su, Jingqian
   Zhou, Fen
   Wu, Shun
   Tong, Zhiyong
TI Research Progress on Natural Small-Molecule Compounds for the Prevention
   and Treatment of Sepsis
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE sepsis; small molecule compounds; inflammatory response; organ failure
ID ACUTE KIDNEY INJURY; NF-KAPPA-B; ACUTE LUNG INJURY; INDUCED
   INFLAMMATION; NLRP3 INFLAMMASOME; SIGNALING PATHWAY; SEPTIC RATS; LPS;
   APOPTOSIS; EXERTS
AB Sepsis is a serious disease with high mortality and has been a hot research topic in medical research in recent years. With the continuous reporting of in-depth research on the pathological mechanisms of sepsis, various compounds have been developed to prevent and treat sepsis. Natural small-molecule compounds play vital roles in the prevention and treatment of sepsis; for example, compounds such as resveratrol, emodin, salidroside, ginsenoside, and others can modulate signaling through the NF-?B, STAT3, STAT1, PI3K, and other pathways to relieve the inflammatory response, immunosuppression, and organ failure caused by sepsis. Here, we discuss the functions and mechanisms of natural small-molecule compounds in preventing and treating sepsis. This review will lay the theoretical foundation for discovering new natural small-molecule compounds that can potentially prevent and treat sepsis.
C1 [Su, Jingqian; Zhou, Fen; Wu, Shun; Tong, Zhiyong] Fujian Normal Univ, Coll Life Sci, Biomed Res Ctr South China, Fujian Key Lab Innate Immune Biol, Fuzhou 350117, Peoples R China.
C3 Fujian Normal University
RP Su, JQ (corresponding author), Fujian Normal Univ, Coll Life Sci, Biomed Res Ctr South China, Fujian Key Lab Innate Immune Biol, Fuzhou 350117, Peoples R China.
EM sjq027@fjnu.edu.cn; 15859446856@163.com;
   qsx20221412@student.fjnu.edu.cn; tongzhiyong1998@163.com
RI Su, Jingqian/AAR-3115-2021
OI Su, Jingqian/0000-0002-0920-7177
FU We would like to thank Songying Ouyang and Qi Chen, who provided
   suggestions regarding the manuscript.
FX We would like to thank Songying Ouyang and Qi Chen, who provided
   suggestions regarding the manuscript.
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Z9 21
U1 1
U2 28
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD AUG
PY 2023
VL 24
IS 16
AR 12732
DI 10.3390/ijms241612732
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA Q1UL9
UT WOS:001055439100001
PM 37628912
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Nie, Y
   Yao, WF
AF Nie, Ying
   Yao, Weifeng
TI A Comprehensive Quality Evaluation Method Based on C30-HPLC
   and an Analytic Hierarchy Process for the Chinese Herbal Formula,
   Erzhiwan
SO MOLECULES
LA English
DT Article
DE analytic hierarchy process; C-30-HPLC; Erzhiwan; herbal formula; quality
   evaluation
ID IN-VITRO; ANTIOXIDANT; MEDICINE; WEDELOLACTONE; SALIDROSIDE;
   FINGERPRINT; SEPARATION; RESPONSES; INJURY; ACID
AB The quantitative analysis of multiple indexes remains an important quality evaluation method of traditional Chinese medicine (TCM) herbal formulas. The Chinese Pharmacopoeia 2015 only stipulates the content of a single component, specnuezhenide, in Erzhiwan composed of the Fructus Ligustri Lucidi (FLL) powder and aqueous extracts of Herba Ecliptae (HE). To generalize the intrinsic quality of Erzhiwan, a novel C-30-HPLC method with good precision, accuracy, and reproducibility was developed for the simultaneous determination of six compounds, including two isomers, and then an analytic hierarchy process was further applied to integrate and discriminate the quality of four samples prepared via different methods. The results of the analysis were in agreement with the antioxidant tests in vitro. This comprehensive strategy could provide a reference and suggestions for the improvement of the quality evaluation method of TCM herbal formulas.
C1 [Nie, Ying] China Pharmaceut Univ, Sch Pharm, Nanjing 210009, Peoples R China.
   [Yao, Weifeng] Nanjing Univ Chinese Med, Sch Pharm, Nanjing 210023, Jiangsu, Peoples R China.
C3 China Pharmaceutical University; Nanjing University of Chinese Medicine
RP Yao, WF (corresponding author), Nanjing Univ Chinese Med, Sch Pharm, Nanjing 210023, Jiangsu, Peoples R China.
EM nieyingcpu@163.com; yaowf@njucm.edu.cn
RI Yao, Weifeng/I-7394-2013
FU National Natural Science Foundation of China [81573554]; Priority
   Academic Program Development of Jiangsu Higher Education Institutions
   (PAPD); Qing Lan Project of Jiangsu Province; Six Talent Peaks Project
   in Jiangsu Province [2016-YY-026]
FX This work was financially supported by the National Natural Science
   Foundation of China (Grant No. 81573554), and a Project Funded by the
   Priority Academic Program Development of Jiangsu Higher Education
   Institutions (PAPD). This research was also supported by a Project
   Funded by the Qing Lan Project of Jiangsu Province and the Six Talent
   Peaks Project in Jiangsu Province (2016-YY-026).
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NR 32
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Z9 15
U1 2
U2 27
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1420-3049
J9 MOLECULES
JI Molecules
PD AUG
PY 2018
VL 23
IS 8
AR 2045
DI 10.3390/molecules23082045
PG 11
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA GU5AA
UT WOS:000445295500210
PM 30111749
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Wang, T
   Zhang, XY
   Xie, WY
AF Wang, Tian
   Zhang, Xiaoying
   Xie, Wenyan
TI Cistanche deserticola Y. C. Ma, "Desert Ginseng": A Review
SO AMERICAN JOURNAL OF CHINESE MEDICINE
LA English
DT Article
DE Cistanche deserticola Y. C. Ma (C. deserticola); Phenylethanoid
   Glycosides (PhGs); Traditional Chinese Medicine (TCM); Tonifying Kidney;
   Antioxidative Effect; Neuroprotective Activity; Review
ID 1-METHYL-4-PHENYLPYRIDINIUM ION; PHENYLETHANOID OLIGOGLYCOSIDES;
   PHENYLPROPANOID GLYCOSIDES; HEPATOPROTECTIVE ACTIVITY; NEURONAL CELLS;
   ECHINACOSIDE; SALIDROSIDE; APOPTOSIS; ACTEOSIDE; EXTRACT
AB Cistanche deserticola Y. C. Ma (C. deserticola, "Rou Cong Rong" in Chinese) is an officinal plant that grows in arid or semi-arid areas. The dried fleshy stem of C. deserticola has been generally used as a tonic in China and Japan for many years. Modern pharmacology studies have since demonstrated that C. deserticola possesses broad medicinal functions, especially for use in hormone regulation, aperient, immunomodulatory, neuroprotective, antioxidative, anti-apoptotic, anti-nociceptive, anti-inflammatory, anti-fatigue activities and the promotion of bone formation. The phenylethanoid glycosides (PhGs) presented in C. deserticola have been identified as the major active components. This review summarizes the up-to-date and comprehensive information on C. deserticola covering the aspects of the botany, traditional uses, phytochemistry, and pharmacology.
C1 [Wang, Tian; Zhang, Xiaoying; Xie, Wenyan] NW A&F Univ, Coll Vet Med, Yangling 712100, Shaanxi, Peoples R China.
C3 Northwest A&F University - China
RP Zhang, XY (corresponding author), NW A&F Univ, Coll Vet Med, Post Box 19,Xinong Rd 22, Yangling 712100, Shaanxi, Peoples R China.
EM zhang.xy@nwsuaf.edu.cn
RI Zhang, Xiaoying/O-2606-2016; xie, wenyan/KRP-5540-2024
OI Zhang, Xiaoying/0000-0002-0055-7322; xie, wenyan/0000-0001-6898-3216
FU Ministry of Education and State Administration of Foreign Experts
   Affairs "Overseas Teacher" project [MS2011XBNL057]; Northwest A & F
   University, China [01140407]
FX This work was supported by the Ministry of Education and State
   Administration of Foreign Experts Affairs "Overseas Teacher" project
   (No. MS2011XBNL057) and a grant (No. 01140407) for returned oversee
   Chinese scholars of Northwest A & F University, China. The authors thank
   Mr. F.M.J. He for his technique support in figure preparation.
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NR 71
TC 129
Z9 150
U1 10
U2 130
PU WORLD SCIENTIFIC PUBL CO PTE LTD
PI SINGAPORE
PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE
SN 0192-415X
EI 1793-6853
J9 AM J CHINESE MED
JI Am. J. Chin. Med.
PY 2012
VL 40
IS 6
BP 1123
EP 1141
DI 10.1142/S0192415X12500838
PG 19
WC Integrative & Complementary Medicine; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; General & Internal Medicine
GA 052PN
UT WOS:000312210400003
PM 23227786
DA 2026-05-27
ER

PT J
AU Qin, YJ
   Su, J
AF Qin, Yajing
   Su, Juan
TI Salidroside suppresses cell growth and inflammatory response of
   fibroblast-like synoviocytes via inhibition of phosphoinositol-3
   kinase/threonine kinase signaling in rheumatoid arthritis
SO ZEITSCHRIFT FUR RHEUMATOLOGIE
LA English
DT Article
DE Synovial tissue hyperplasia; Herbal medicine; Complete Freund's
   adjuvant; TNF-alpha; Fibroblast-like synoviocyte migration
ID IN-VITRO; MYOCARDIAL INJURY; PATHWAY; APOPTOSIS; MIGRATION;
   PROLIFERATION; ACTIVATION; CYTOKINES; INVASION; TARGET
AB Background: Salidroside (Sal) is a natural product commonly isolated from Rhodiola rosea L., which has been found to have numerous pharmacological activities (e.g., ameliorating apoptosis and inflammation, and acting as an antioxidant) in various diseases, but its concrete function in rheumatoid arthritis (RA) has not been revealed yet. Here, we aimed to explore the specific role and underlying mechanisms of Sal in RA-fibroblast-like synoviocytes (RA-FLSs).Methods: Cell counting kit 8 (CCK-8) was used to assess the viability of normal-FLSs and RA-FLSs. Cell apoptosis in RA-FLSs was evaluated by flow cytometry. Western blotting was prepared to examine the levels of apoptosis- and signaling-related proteins. Wound-healing and Transwell assays were conducted to examine RA-FLSs migration and invasion. Enzyme-linked immunosorbent assay (ELISA) was used to assess the effect of Sal on tumor necrosis factor-alpha (TNF-alpha)-induced inflammation in RA-FLSs. RA animal model was established through complete Freund's adjuvant (CFA) induction, and the histopathological changes in synovial tissues of the rat model were analyzed by H&E staining.Results: RA-FLSs were treated with 200 mu M Sal for 24 h, and cell viability was significantly suppressed. Sal promoted RA-FLSs apoptosis. The migratory and invasive abilities of RA-FLSs were markedly inhibited by Sal. Sal incubation reduced the levels of inflammatory cytokines interleukin-8 (IL-8), IL-1 beta, and IL-6 in RA-FLSs under the stimulation of TNF-alpha. Subsequently, Sal downregulated phosphorylated phosphatidylinositol-3 kinase (p-PI3K) and protein kinase (p-AKT) expression in RA-FLSs. After the treatment with pathway activator 740Y-P (20 mu M) in RA-FLSs, the promotive effect of Sal on cell apoptosis was reversed, and inhibitory effects of it on cell viability, migration, invasion, and inflammatory response were abolished. Sal inhibited RA development in the CFA-induced rat model.Conclusion: Sal suppressed cell growth and inflammation in RA-FLSs by inactivating PI3K/AKT-signaling pathways.
C1 [Qin, Yajing; Su, Juan] Qinghai Univ, Affiliated Hosp, Dept Rheumatol & Immunol, Xining, Peoples R China.
   [Su, Juan] Qinghai Univ, Affiliated Hosp, 29 Tongren Rd, Xining, Qinghai, Peoples R China.
C3 Qinghai University; Qinghai University
RP Su, J (corresponding author), Qinghai Univ, Affiliated Hosp, 29 Tongren Rd, Xining, Qinghai, Peoples R China.
EM drsujuan@hotmail.com
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NR 39
TC 6
Z9 8
U1 0
U2 11
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0340-1855
EI 1435-1250
J9 Z RHEUMATOL
JI Z. Rheumatol.
PD FEB
PY 2024
VL 83
IS SUPPL 1
SU 1
SI SI
BP 78
EP 87
DI 10.1007/s00393-023-01431-5
EA OCT 2023
PG 10
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA KA4G7
UT WOS:001089600500003
PM 37851166
DA 2026-05-27
ER

PT J
AU Zhang, YT
   Li, R
   Jiang, H
   Hou, Y
   Zhang, Y
   Meng, XL
   Wang, XB
AF Zhang, Yating
   Li, Rui
   Jiang, Hong
   Hou, Ya
   Zhang, Yi
   Meng, Xianli
   Wang, Xiaobo
TI Salidroside modulates repolarization through stimulating Kv2.1 in rats
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Arrhythmia; Salidroside; Kv2.1 channel; P-V loop; Repolarization
ID OUTWARD K+ CURRENT; LONG-QT SYNDROME; GENE-EXPRESSION; CHANNEL;
   POTASSIUM; BLOCK; HERG; MECHANISM; HYPOXIA; INJURY
AB Background: Voltage-gated potassium (Kv) channel growth is strongly associated with the development of arrhythmia. Salidroside (Sal), an active component from Rhodiola crenulata, has been shown to exert protective effects against heart disease. The present study was conducted to investigate the effects of Sal on Kv2.1 channel, and to explore the ionic mechanism of anti-arrhythmic. Methods: In this study, we utilized cisapride (Cis., A stimulant that prolongs the QT interval and causes cardiac arrhythmias) by intravenous injection to establish an arrhythmia model, and detected the effects of Sal on electrocardiography (ECG) and pressure volume loop (P-V loop) in SD rats. The effect of Sal on ECG of citalopram (Cit., a Kv2 channel inhibition)-evoked arrhythmia rat models was further evaluated by monitoring the dynamic changes of multiple indicators of ECG. Then, we detected the effect of Sal on the viability of hypoxic H9c2 cells using CCK-8 assay. After that, the effect of Sal on Kv channel currents (IKv) and Kv2.1 channel currents (IKv2.1) in H9c2 cells under normal and hypoxic conditions was examined using whole-cell patch clamp technique. In addition, the effect of Sal on IKv and IKv2.1 in H9c2 cells was determined under the inhibition of Kv and Kv2.1 channels. HEK293 cells stably transfected with Kv2.1 plasmids were also used to investigate the IKv2.1 changes under Sal pre-treated and co-incubated conditions. In addition, potential interactions of Sal with Kv2.1 protein were predicted and tested by molecular docking, molecular dynamics simulation (MDS), localized surface plasmon resonance (LSPR), and cellular thermal shift assay (CETSA) techniques, respectively. Furthermore, gene and protein levels of Kv2.1 in Sal-treated H9c2 cell were estimated by qRT-PCR, Western blot (WB) and immunofluorescence (IF) analysis. Results: Sal shortened the prolongated QT interval and ameliorated the cardiac impairment associated with arrhythmia in SD rats caused by Cis., as reflected in the ECG and P-V loop data. And Sal was also protective against arrhythmia in rats caused by Kv2 channel inhibition. At the cellular level, Sal increased cell viability after CoCl2-induced hypoxic injury in H9c2 cells. Whole-cell patch clamp assay confirmed that Sal inhibited both IKv and IKv2.1 in normal H9c2 cells, while enhanced IKv and IKv2.1 in cardiomyocytes after hypoxic injury. And Sal enhanced IKv inhibited by 1.5 mM 4-AP and upregulated all inhibition of Kv2 channels induced by 20 mM 4-AP administration, antagonized the IKv2.1 inhibitory effect of Cit. Moreover, Sal pre-administration for 24 h and immediate administration increased IKv2.1 in HEK293 cells stably transfected with Kv2.1 plasmids. Molecular docking demonstrated the potential binding of Sal to the Kv2.1 protein, with calculated binding energy of -5.4 kcal/mol. MDS test illustrated that the average hydrogen bonding of the Sal-Kv2.1 complexes was 30.89%. LSPR results verified the potential binding of Sal to Kv2.1 protein with an affinity value of 9.95 x 10-4 M. CETSA assay confirmed Sal can enhance the expression of Kv2.1 protein in H9c2 cells treated with heat, which suggests that Sal may bind to Kv2.1 protein. The results of WB, qRT-PCR, and IF further argued that Sal pre-administration for 24 h enhanced the levels of the Kv2.1 gene and protein (with no effects on the Kv2.1 gene and protein for H9c2 cells co-incubated with Sal for 6 h and 12 h).
   Conclusion: Overall, our findings indicate that Sal can resist drug-induced arrhythmias in SD rats, partially by modulating repolarization through stimulating Kv2.1.
C1 [Zhang, Yating; Jiang, Hong; Hou, Ya; Zhang, Yi; Meng, Xianli; Wang, Xiaobo] Chengdu Univ Tradit Chinese Med, Sch Pharm, Sch Modern Chinese Med Ind, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China.
   [Zhang, Yating; Jiang, Hong; Meng, Xianli; Wang, Xiaobo] Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Acad Interdiscipline, Chengdu 611137, Peoples R China.
   [Li, Rui; Jiang, Hong; Meng, Xianli; Wang, Xiaobo] Chengdu Univ Tradit Chinese Med, Res Serv Off, Meishan Hosp, Meishan 620000, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine; Chengdu University of Traditional
   Chinese Medicine
RP Meng, XL; Wang, XB (corresponding author), Chengdu Univ Tradit Chinese Med, Sch Pharm, Sch Modern Chinese Med Ind, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China.
EM zhangyating@stu.cdutcm.edu.cn; xlm999@cdutcm.edu.cn;
   VitaDrwang@cdutcm.edu.cn
FU National Natural Science Foundation of China [82274207, 82104533];
   Science & Technology Department of Sichuan Province [2024NSFSC1845,
   2024NSFSC0701, 2024NSFSC0697]; Xinglin Scholar Research Promotion
   Project of Chengdu University of TCM [QJRC2023037, XKTD2022013]
FX This work was supported by the National Natural Science Foundation of
   China (82274207 and 82104533) , the Science & Technology Department of
   Sichuan Province (2024NSFSC1845, 2024NSFSC0701 and 2024NSFSC0697) , and
   the Xinglin Scholar Research Promotion Project of Chengdu University of
   TCM (QJRC2023037 and XKTD2022013) .
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NR 61
TC 5
Z9 5
U1 2
U2 13
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD AUG 15
PY 2024
VL 977
AR 176741
DI 10.1016/j.ejphar.2024.176741
EA JUN 2024
PG 19
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA I8V1M
UT WOS:001332967500001
PM 38880221
DA 2026-05-27
ER

PT J
AU Mu, L
   Wang, G
   Yang, XB
   Liang, J
   Tong, H
   Li, LY
   Geng, KY
   Bo, YN
   Hu, XD
   Yang, RB
   Xu, XQ
   Zhang, Y
   Zhang, H
AF Mu, Lu
   Wang, Ge
   Yang, Xuebing
   Liang, Jing
   Tong, Huan
   Li, Lingyu
   Geng, Kaiying
   Bo, Yingnan
   Hu, Xindi
   Yang, Ruobing
   Xu, Xueqiang
   Zhang, Yan
   Zhang, Hua
TI Physiological premature aging of ovarian blood vessels leads to decline
   in fertility in middle-aged mice
SO NATURE COMMUNICATIONS
LA English
DT Article
ID ANGIOGENESIS; FOLLICLE; GROWTH; CELLS; OOCYTES; ATLAS; VEGF
AB Ovarian function declines significantly as females enter middle-age, but the mechanisms underlying this decline remain unclear. Here, we utilize whole-organ imaging to observe a notable decrease in ovarian blood vessel (oBV) density and angiogenesis intensity of middle-aged mice. This leads to a diminished blood supply to the ovaries, resulting in inadequate development and maturation of ovarian follicles. Utilizing genetic-modified mouse models, we demonstrate that granulosa cell secreted VEGFA governs ovarian angiogenesis, but the physiological decline in oBV is not attributed to VEGFA insufficiency. Instead, through single-cell sequencing, we identify the aging of the ovarian vascular endothelium as the primary factor contributing to oBV decline. Consequently, the administration of salidroside, a natural compound that is functional to reverse oBV aging and promote ovarian angiogenesis, significantly enhances ovarian blood supply and improve fertility in older females. Our findings highlight that enhancing oBV function is a promising strategy to boost fertility in females.
C1 [Mu, Lu; Wang, Ge; Yang, Xuebing; Liang, Jing; Tong, Huan; Li, Lingyu; Geng, Kaiying; Bo, Yingnan; Hu, Xindi; Yang, Ruobing; Xu, Xueqiang; Zhang, Yan; Zhang, Hua] China Agr Univ, Coll Biol Sci, State Key Lab Anim Biotech Breeding, Beijing, Peoples R China.
   [Xu, Xueqiang] Peking Univ, Acad Adv Interdisciplinary Studies, Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China.
C3 China Agricultural University; Peking University
RP Zhang, H (corresponding author), China Agr Univ, Coll Biol Sci, State Key Lab Anim Biotech Breeding, Beijing, Peoples R China.
EM huazhang@cau.edu.cn
RI ; li, lingyu/JLL-2578-2023; Hu, xindi/GSI-9429-2022; mu,
   lu/LZG-4045-2025
OI Zhang, Hua/0000-0002-4700-5971; Xu, Xueqiang/0000-0001-8240-3521
FU National Science Foundation of China | Key Programme [2022YFC2703803];
   National Key Research and Development Program of China [82230051]; Key
   Program of National Natural Science Foundation of China [2023SKLAB1-6,
   1021-00109035]; Innovative Project of State Key Laboratory of Animal
   Biotech Breeding
FX The authors are grateful to Dr. Longzhong Jia (School of Life Sciences,
   Tsinghua University) and Wenji Wang (School of Life Sciences, Taizhou
   University), Dr. Da Mi (School of Life Sciences, Tsinghua University)
   for scRNA-seq technology support. This study was supported by the
   National Key Research and Development Program of China to H.Z.
   (2022YFC2703803), the Key Program of National Natural Science Foundation
   of China to H.Z. (82230051), the Innovative Project of State Key
   Laboratory of Animal Biotech Breeding to H.Z. (2023SKLAB1-6) and the
   2115 Talent Development Program of China Agricultural University to H.Z.
   (1021-00109035).
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NR 70
TC 34
Z9 35
U1 13
U2 61
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
EI 2041-1723
J9 NAT COMMUN
JI Nat. Commun.
PD JAN 2
PY 2025
VL 16
IS 1
AR 72
DI 10.1038/s41467-024-55509-y
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA R2Q5D
UT WOS:001389959100044
PM 39747922
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Lee, JI
   Hwang, IH
   Jang, TS
   Na, MK
AF Lee, JungIn
   Hwang, In Hyun
   Jang, Tae Su
   Na, MinKyun
TI Isolation and Quantification of Phenolic Compounds in Acer
   tegmentosum by High Performance Liquid Chromatography
SO BULLETIN OF THE KOREAN CHEMICAL SOCIETY
LA English
DT Article
DE Acer tegmentosum; Quantification method; High performance liquid
   chromatography
ID THISTLE SILYBUM-MARIANUM; OXIDATIVE STRESS; CONSTITUENTS; SEPARATION;
   SILYMARIN; EXTRACT; CANCER; BARK
AB Determination of bioactive chemicals in Acer tegmentosum is essential for its industrial application. Twelve phenolic compounds were isolated from A. tegmentosum. Specific seven compounds in the plant were simultaneously analyzed by high performance liquid chromatography-UV. The content of bioactive chemicals in the branch extract was determined to be 3.38 mg/g of (-)-epigallocatechin, 66.95 mg/g of salidroside, 39.61 mg/g of tyrosol, 17.04 mg/g of catechin, 7.39 mg/g of 1,2,4-tri-O-galloyl-beta-D-glucose, 8.88 mg/g of 6-O-galloylsalidroside, and 4.61 mg/g of scopoletin. The method was validated with linearity (R-2 > 0.9947), as well as intra-and inter-day precision (0.07-2.77%) and accuracy (> 97.0%). This analytical method is expected to be applied for standardization of dietary food containing A. tegmentosum.
C1 [Lee, JungIn; Na, MinKyun] Chungnam Natl Univ, Coll Pharm, Daejeon 34134, South Korea.
   [Hwang, In Hyun] UT Southwestern Med Ctr, Dept Biochem, Dallas, TX 75235 USA.
   [Jang, Tae Su] Seoul Natl Univ, Inst Green Bio Sci & Technol, Seoul 151742, South Korea.
C3 Chungnam National University; University of Texas System; University of
   Texas Southwestern Medical Center; Seoul National University (SNU)
RP Na, MK (corresponding author), Chungnam Natl Univ, Coll Pharm, Daejeon 34134, South Korea.; Jang, TS (corresponding author), Seoul Natl Univ, Inst Green Bio Sci & Technol, Seoul 151742, South Korea.
EM jangts@snu.ac.kr; mkna@cnu.ac.kr
RI Na, MinKyun/K-4873-2013
OI Na, MinKyun/0000-0002-4865-6506
FU Ministry of Trade, Industry and Energy, Republic of Korea. [R0004165]
FX This study was supported by Ministry of Trade, Industry and Energy
   (R0004165), Republic of Korea.
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NR 29
TC 4
Z9 5
U1 0
U2 15
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 0253-2964
EI 1229-5949
J9 B KOREAN CHEM SOC
JI Bull. Korean Chem. Soc.
PD MAR
PY 2017
VL 38
IS 3
BP 392
EP 396
DI 10.1002/bkcs.11099
PG 5
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA EP1VM
UT WOS:000397172400016
DA 2026-05-27
ER

PT J
AU Song, YF
   Han, B
   Feng, YF
   Jiang, YJ
   Zhang, WM
   Wang, HM
   Xin, FX
   Jiang, WK
AF Song, Yifan
   Han, Bing
   Feng, Yifan
   Jiang, Yujia
   Zhang, Wenming
   Wang, Hongmei
   Xin, Fengxue
   Jiang, Wankui
TI Recent Advances in the Biological Synthesis of l-Tyrosine Derivatives by
   Genetically Engineered Microbes
SO ACS SYNTHETIC BIOLOGY
LA English
DT Review
DE engineered microbes; l-tyrosine derivatives; aromatic compounds;
   biosynthesis; metabolicengineering
ID P-COUMARIC ACID; ESCHERICHIA-COLI; L-DOPA; ANTIOXIDANT ACTIVITY;
   IN-VITRO; PATHWAY; METABOLISM; HYDROXYTYROSOL; SALIDROSIDE; EVOLUTION
AB l-Tyrosine (l-Tyr) is an important aromatic amino acid. Meanwhile, derivatives of l-Tyr also exhibit promising applications across various industries, including food, cosmetics, and pharmaceuticals. Empowered by synthetic biology, the biological synthesis of l-Tyr derivatives via microbial fermentation has emerged as a promising alternative to overcome the limitations of traditional production methods, such as the low production efficiency, high cost, and environmental pollution. This review summarized recent advances on the biological synthesis of l-Tyr derivatives, including tyrosol, levodopa (l-DOPA), p-coumaric acid (p-CA), and relevant derivatives by different microorganisms. Strategies for improving the production of l-Tyr derivatives including metabolic engineering, enzyme modification, and strain breeding were also introduced. In addition, the future development trend of the microbial synthesis of l-tyrosine derivatives was proposed.
C1 [Song, Yifan; Han, Bing; Feng, Yifan; Jiang, Yujia; Zhang, Wenming; Xin, Fengxue; Jiang, Wankui] Nanjing Tech Univ, Coll Biotechnol & Pharmaceut Engn, State Key Lab Mat Oriented Chem Engn, Nanjing 211816, Peoples R China.
   [Wang, Hongmei] Huanghe Sci & Technol Coll, Inst Agr Engn, Zhengzhou 450006, Peoples R China.
C3 Nanjing Tech University
RP Xin, FX; Jiang, WK (corresponding author), Nanjing Tech Univ, Coll Biotechnol & Pharmaceut Engn, State Key Lab Mat Oriented Chem Engn, Nanjing 211816, Peoples R China.; Wang, HM (corresponding author), Huanghe Sci & Technol Coll, Inst Agr Engn, Zhengzhou 450006, Peoples R China.
EM whm8998@163.com; xinfengxue@njtech.edu.cn; jiangwankui@njtech.edu.cn
OI Zhang, Wenming/0000-0002-9575-7713
FU National Natural Science Foundation of China [2023YFC3403500]; National
   Key Research and Development Program of China [22408164, 22478183,
   22378199]; National Natural Science Foundation of China [BK20220052];
   Jiangsu Natural Science Fund for Distinguished Young Scholars
   [202306155]; Shandong Taishan Industrial Experts Program [KL-MCE-23A10];
   State Key Laboratory of Materials-Oriented Chemical Engineering [CX(24)
   3085]; Jiangsu Agriculture Science and Technology Independent Innovation
   Fund Project (JASTIF) [BK20233003]; Jiangsu Basic Research Center for
   Synthetic Biology
FX This work was supported by the National Key Research and Development
   Program of China (2023YFC3403500), the National Natural Science
   Foundation of China (22408164, 22478183, and 22378199), the Jiangsu
   Natural Science Fund for Distinguished Young Scholars (BK20220052), the
   Shandong Taishan Industrial Experts Program (202306155), the State Key
   Laboratory of Materials-Oriented Chemical Engineering (KL-MCE-23A10),
   the Jiangsu Agriculture Science and Technology Independent Innovation
   Fund Project (JASTIF, CX(24) 3085), and the Jiangsu Basic Research
   Center for Synthetic Biology (BK20233003)
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NR 142
TC 6
Z9 6
U1 30
U2 47
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 2161-5063
J9 ACS SYNTH BIOL
JI ACS Synth. Biol.
PD SEP 19
PY 2025
VL 14
IS 9
BP 3332
EP 3347
DI 10.1021/acssynbio.5c00475
EA AUG 2025
PG 16
WC Biochemical Research Methods
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 7NP5A
UT WOS:001554084200001
PM 40833382
DA 2026-05-27
ER

PT J
AU Jiao, Y
   Zhao, ZL
   Li, X
   Li, LL
   Xiao, D
   Wan, SY
   Wu, T
   Li, T
   Li, P
   Zhao, RJ
AF Jiao, Yu
   Zhao, Zhenglin
   Li, Xin
   Li, Lulu
   Xiao, Dan
   Wan, Siyuan
   Wu, Tong
   Li, Tong
   Li, Ping
   Zhao, Rongjie
TI Salidroside ameliorates memory impairment following long-term ethanol
   intake in rats by modulating the altered intestinal microbiota content
   and hippocampal gene expression
SO FRONTIERS IN MICROBIOLOGY
LA English
DT Article
DE Salidroside; ethanol; memory impairment; gut microbiota; hippocampus;
   metagenomics
AB BackgroundSalidroside (Sal), the main component of a famous herb Rhodiola rosea L, enhances memory performance and reduces fatigue. Therefore, this study assessed the effect of Sal on memory impairment induced by a long-term intake of ethanol (EtOH) in rats and investigated its relevant mechanisms using gut microbiota metagenomic analysis and hippocampal transcriptomic analysis. MethodsEighteen male SD rats were divided into the normal control group (CON group), EtOH model group (Model group), and Sal treatment group (Sal group). The rats in the Model and Sal groups intragastrically (i.g.) received 2 g/kg EtOH for 30 consecutive days, whereas the CON group was given an equal volume of distilled water. Meanwhile, the rats in the Sal group were administered i.g. 30 mg/kg Sal 60 min after EtOH intake. All rats were tested in the eight-arm maze for their memory function every 3 days. On the 30th day, metagenomic analyses of gut microbiota and transcriptomic analyses of the hippocampus were performed. ResultsCompared with the Model group, Sal treatment reduced the total time to complete the eight-arm maze task, decreased the number of arm entries, and abated the working memory error that was significant from the 9th day. Additionally, Sal intervention improved the gut microbiota composition, such as the increased abundance of Actinobacteria and Bifidobacterium, which was related to the metabolism of amino acids and terpenoid carbohydrate, endocrine function, and signal transduction by neurotransmitters. In the hippocampus, the EtOH intake differentially expressed 68 genes (54 genes increased, whereas 14 genes decreased), compared with the CON group, whereas Sal intervention affected these changes: 15 genes increased whereas 11 genes decreased. And, enrichment analyses revealed these genes were related to the structural components of the ribosome, mRNA splicing process, protein translation, mitochondria function, and immunological reaction. Finally, a correlation analysis found the memory impairment was positively correlated with the abnormal upregulation of Tomm7 but negatively correlated with decreased abundance of gut Alistipes_indistinctus, Lactobacillus_taiwanensis, Lactobacillus_paragasseri, and Lactobacillus johnsonii. ConclusionSal improved memory impairment caused by long-term EtOH intake in rats, which may be related to its regulation of gut dysbiosis and hippocampal dysfunction.
C1 [Jiao, Yu; Wu, Tong; Li, Tong; Li, Ping; Zhao, Rongjie] Qiqihar Med Univ, Dept Psychiat, Qiqihar, Heilongjiang, Peoples R China.
   [Zhao, Zhenglin; Li, Lulu] Qiqihar Med Univ, Dept Biochem, Qiqihar, Heilongjiang, Peoples R China.
   [Li, Xin] Qiqihar Med Univ, Dept Psychiat, Affiliated Hosp 4, Qiqihar, Heilongjiang, Peoples R China.
   [Xiao, Dan] Harbin Inst Technol, Sch Med & Hlth, Harbin, Heilongjiang, Peoples R China.
   [Xiao, Dan] Harbin Inst Technol, Dept Med & Hlth, Zhengzhou Res Inst, Zhengzhou, Henan, Peoples R China.
   [Wan, Siyuan] Qiqihar Med Univ, Dept Prevent Med, Qiqihar, Heilongjiang, Peoples R China.
C3 Qiqihar Medical University; Qiqihar Medical University; Qiqihar Medical
   University; Harbin Institute of Technology; Harbin Institute of
   Technology; Qiqihar Medical University
RP Li, P; Zhao, RJ (corresponding author), Qiqihar Med Univ, Dept Psychiat, Qiqihar, Heilongjiang, Peoples R China.
EM lipingchxyy@163.com; zhao_rongjie@yahoo.com
RI Li, Ping/GYV-4914-2022; Xiao, Dan/JXW-9182-2024
OI Xiao, Dan/0009-0008-2177-6795
FU National Natural Science Foundation of China [82104173]; Qiqihar Academy
   of Medical Sciences [QMSI2019M-09]; Heilongjiang Provincial College
   Students Innovation and Entrepreneurship Project [201911230056]; Science
   Research Foundation of Qiqihar Medical Institute [2021-ZDPY-014];
   Science Research Foundation of Qiqihar city, China [LHYD-2021015];
   Science Research Foundation of Qiqihar city, Qiqihar city, China
   [LHYD-202011]
FX This study was funded by the National Natural Science Foundation of
   China (82104173), and Qiqihar Academy of Medical Sciences, Grant No.
   QMSI2019M-09; Heilongjiang Provincial College Students Innovation and
   Entrepreneurship Project, Grant No. 201911230056; The Science Research
   Foundation of Qiqihar Medical Institute No. 2021-ZDPY-014; The Science
   Research Foundation of Qiqihar city, China No. LHYD-2021015; The Science
   Research Foundation of Qiqihar city, Qiqihar city, China No.
   LHYD-202011.
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NR 65
TC 11
Z9 11
U1 0
U2 20
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-302X
J9 FRONT MICROBIOL
JI Front. Microbiol.
PD JUN 9
PY 2023
VL 14
AR 1172936
DI 10.3389/fmicb.2023.1172936
PG 14
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA K4LU0
UT WOS:001016177600001
PM 37362918
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Harsányová, T
   Wolaschka, T
   Matusová, D
   Bauerová, K
AF Harsanyova, Terezia
   Wolaschka, Tomas
   Matusova, Desana
   Bauerova, Katarina
TI Influence of Technological Properties of Dry Extract on Properties of
   Tablets
SO CHEMICKE LISTY
LA Slovak
DT Article
DE extract; Rhodiola rosea; peroral tablets; sorbitol; microcrystalline
   cellulose; dissolution
AB Salidroside, as a chemical compound from the group of phenylpropanoids, and rosavin are used for the standardization of dry extracts from the underground stem and root of Rhodiola rosea. In this study we monitored two different extracts from Rhodiola rosea, which differ in content of active compounds, colour, technological and physico-chemical properties (e.g. flow properties). These extracts were mixed with excipients and the flow characteristics of mixture bulk volume and tapped volume were determined. After formulating the tablets by compression, qualitative parameters like disintegration, resistance to crushing, friability, mass uniformity and texturometric parameters were tested. Also, dissolution profiles were evaluated using first order kinetic model, Korsmeyer-Peppas model and Weibull model for correlation. In some formulations, the impact of the properties of dry extracts on various technological properties of final tablets was more marked. We suggest that in case of a higher extract:excipients ratio, these properties manifest themselves by an even higher impact.
C1 [Harsanyova, Terezia; Matusova, Desana; Bauerova, Katarina] Univ Komenskeho, Farmaceut Fak, Katedra Galenickej Farm, Odbojarov 10, Bratislava 83232, Slovakia.
   [Wolaschka, Tomas] Univ Vet Lekarstva Farm & Kosiciach, Katedra Farmaceut Technol, Komenskeho 73, Kosice 04181, Slovakia.
   [Bauerova, Katarina] Slovak Acad Sci, Ustav Expt Farmakol Toxikol, Ctr Expt Med, Dubravska Cesta 9, Bratislava 84104, Slovakia.
C3 Comenius University Bratislava; Slovak Academy of Sciences; Centre of
   Experimental Medicine, SAS
RP Harsányová, T (corresponding author), Univ Komenskeho, Farmaceut Fak, Katedra Galenickej Farm, Odbojarov 10, Bratislava 83232, Slovakia.
EM terezia.harsanyova@gmail.com
RI Bauerova, Katarina/JBR-8725-2023; /AAQ-7883-2021
FU  [APVV-15-0308];  [VEGA 2/0115/19];  [HMS 26210120028]
FX The work was supported by grants APVV-15-0308, VEGA 2/0115/19 and a
   projectfrom structuralfunds Renewal of research and development
   infrastructure and equipment at ULF", HMS 26210120028.
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NR 15
TC 1
Z9 1
U1 0
U2 3
PU CHEMICKE LISTY
PI PRAGUE 6
PA NOVOTNEHO LAVKA 5, PRAGUE 6 116 68, CZECH REPUBLIC
SN 0009-2770
EI 1213-7103
J9 CHEM LISTY
JI Chem. Listy
PY 2020
VL 114
IS 12
BP 847
EP 852
PG 6
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA PF3JJ
UT WOS:000598954700009
DA 2026-05-27
ER

PT J
AU Jiang, MY
   Xu, GC
   Ni, J
   Zhang, K
   Dong, JJ
   Han, RZ
   Ni, Y
AF Jiang, Mingyang
   Xu, Guochao
   Ni, Jie
   Zhang, Kai
   Dong, Jinjun
   Han, Ruizhi
   Ni, Ye
TI Improving Soluble Expression of Tyrosine Decarboxylase from
   Lactobacillus brevis for Tyramine Synthesis with High Total Turnover
   Number
SO APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
LA English
DT Article
DE Soluble expression; Tyrosine decarboxylase; Tyramine; Glucose; Tween-80
ID IN-VITRO; PURIFICATION; SALIDROSIDE; ACID; GENE; RECEPTOR
AB The soluble expression of tyrosine decarboxylase (TDC) in heterologous host is often challenging. Here, acidic condition was found to be favorable for improving the soluble expression of TDC from Lactobacillus brevis in Escherichia coli, while addition of carbohydrates (such as glucose, arabinose, and fructose) was vital for decreasing the insoluble fraction. By simple pH control and addition of glucose, the specific activity of TDC in crude extract was enhanced to 46.3Umg(-1), 3.67-fold of that produced from LB medium. Optimization of the reaction conditions revealed that Tween-80 was effective in improving the tyramine production catalyzed by TDC, especially at high tyrosine loadings. As much as 400mM tyrosine could be completely converted into tyramine with a substrate to catalyst ratio of 29.0gg(-1) and total turnover number of 23,300. This study provides efficient strategies for the highly soluble expression of TDC and biocatalytic production of tyramine.
C1 [Jiang, Mingyang; Xu, Guochao; Ni, Jie; Dong, Jinjun; Han, Ruizhi; Ni, Ye] Jiangnan Univ, Sch Biotechnol, Minist Educ, Key Lab Ind Biotechnol, Wuxi 214122, Jiangsu, Peoples R China.
   [Zhang, Kai] SUNY Stony Brook, Dept Biochem & Cell Biol, Stony Brook, NY 11794 USA.
C3 Jiangnan University; State University of New York (SUNY) System; Stony
   Brook University
RP Jiang, MY (corresponding author), Jiangnan Univ, Sch Biotechnol, Minist Educ, Key Lab Ind Biotechnol, Wuxi 214122, Jiangsu, Peoples R China.
EM yni@jiangnan.edu.en
RI Han, Ruizhi/HJY-5563-2023; Ni, Jie/PRV-8611-2026; guochao,
   xu`/AAV-6760-2021; Ni, Ye/P-3977-2019
OI Zhang, Kai/0009-0001-6168-7569; Ni, Ye/0000-0003-4887-7517
FU National Natural Science Foundation of China [21506073, 21776112];
   Natural Science Foundation of Jiangsu Province [BK20150003, BK20171135];
   six talent peaks project of Jiangsu Province [2015-SWYY-008]; Program of
   Introducing Talents of Discipline to Universities [111-2-06]; Priority
   Academic Program Development of Jiangsu Higher Education Institutions;
   national first-class discipline program of Light Industry Technology and
   Engineering [LITE2018-07]
FX The study was financially supported by the National Natural Science
   Foundation of China (21506073, 21776112), the Natural Science Foundation
   of Jiangsu Province (BK20150003, BK20171135), six talent peaks project
   of Jiangsu Province (2015-SWYY-008), national first-class discipline
   program of Light Industry Technology and Engineering (LITE2018-07), the
   Program of Introducing Talents of Discipline to Universities (111-2-06),
   and a project funded by the Priority Academic Program Development of
   Jiangsu Higher Education Institutions.
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NR 30
TC 12
Z9 14
U1 3
U2 53
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0273-2289
EI 1559-0291
J9 APPL BIOCHEM BIOTECH
JI Appl. Biochem. Biotechnol.
PD JUN
PY 2019
VL 188
IS 2
BP 436
EP 449
DI 10.1007/s12010-018-2925-x
PG 14
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
GA HY5JZ
UT WOS:000468165500011
PM 30520007
DA 2026-05-27
ER

PT J
AU Liu, Y
   Zhou, R
   Guo, YF
   Hu, B
   Xie, LQ
   An, YZ
   Wen, J
   Liu, ZY
   Zhou, M
   Kuang, WH
   Xiao, Y
   Wang, M
   Xie, GQ
   Zhou, HY
   Lu, RB
   Peng, H
   Huang, Y
AF Liu, Ya
   Zhou, Rui
   Guo, Yifan
   Hu, Biao
   Xie, Lingqi
   An, Yuze
   Wen, Jie
   Liu, Zheyu
   Zhou, Min
   Kuang, Weihong
   Xiao, Yao
   Wang, Min
   Xie, Genqing
   Zhou, Haiyan
   Lu, Renbin
   Peng, Hui
   Huang, Yan
TI Muscle-derived small extracellular vesicles induce liver fibrosis during
   overtraining
SO CELL METABOLISM
LA English
DT Article
ID LACTATE; EXPRESSION; CROSSTALK
AB The benefits of exercise for metabolic health occur in a dose-dependent manner. However, the adverse effects of overtraining and their underlying mechanisms remain unclear. Here, we show that overtraining induces hepatic fibrosis. Mechanistically, we find that excessive lactate accumulation in skeletal muscle leads to the lactylation of SH3 domain-containing 3 (SORBS3), triggering its liquid-liquid phase separation (LLPS). LLPS of SORBS3 enhances its interaction with flotillin 1 and selectively facilitates the sorting of F-box protein 2 (FBXO2) into small extracellular vesicles, referred to as "lactate bodies."Lactate bodies induce hepatocyte apoptosis followed by hepatic stellate cell activation via myeloid cell leukemia sequence 1 (MCL1)-BAX/BAK signaling. Inhibition of SORBS3 lactylation or FBXO2 disrupts lactate bodies formation and alleviates over-training-triggered liver fibrosis. Likewise, reduction of muscle lactate bodies formation by salidroside attenuates overtraining-induced liver fibrosis. Collectively, we identify a process by which overtraining induces hepatic fibrosis, highlighting a potential therapeutic target for liver health.
C1 [Liu, Ya; Zhou, Rui; Guo, Yifan; Hu, Biao; Xie, Lingqi; An, Yuze; Wen, Jie; Liu, Zheyu; Zhou, Min; Kuang, Weihong; Xiao, Yao; Wang, Min; Zhou, Haiyan; Lu, Renbin; Peng, Hui; Huang, Yan] Cent South Univ, Xiangya Hosp, Endocrinol Res Ctr, Dept Endocrinol, Changsha 410008, Hunan, Peoples R China.
   [Xie, Genqing] First Peoples Hosp Xiangtan City, Dept Endocrinol, Xiangtan 411100, Hunan, Peoples R China.
   [Huang, Yan] Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 410008, Hunan, Peoples R China.
   [Huang, Yan] FuRong Lab, Changsha 410078, Hunan, Peoples R China.
C3 Central South University; Central South University; Furong Laboratory
RP Lu, RB; Peng, H; Huang, Y (corresponding author), Cent South Univ, Xiangya Hosp, Endocrinol Res Ctr, Dept Endocrinol, Changsha 410008, Hunan, Peoples R China.; Huang, Y (corresponding author), Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 410008, Hunan, Peoples R China.; Huang, Y (corresponding author), FuRong Lab, Changsha 410078, Hunan, Peoples R China.
EM lurenbin@sklmg.edu.cn; penghui11083@csu.edu.cn; yanhuang1018@csu.edu.cn
RI Peng, HuiTing/OSH-7186-2025
FU National Natural Science Foundation of China [82370883]; Natural Science
   Foundation of Hunan Province, China [2023JJ30890]; Major Research plan
   of the National Natural Science Foundation of China [92149306]; Projects
   of International Cooperation and Exchanges NSFC [82120108009]; Key
   Program of National Natural Science Foundation of China [81930022];
   Major Project of Natural Science Foundation of Hunan Province (Open
   Competition) [2021JC0002-06]; Scientific Research Program of FuRong
   Laboratory [2024PT5104]
FX This work was supported by the National Natural Science Foundation of
   China (grant no. 82370883) , the Natural Science Foundation of Hunan
   Province, China (grant no. 2023JJ30890) , the Major Research plan of the
   National Natural Science Foundation of China (grant no. 92149306) , the
   Projects of International Cooperation and Exchanges NSFC (grant no.
   82120108009) , the Key Program of National Natural Science Foundation of
   China (grant no. 81930022) , the Major Project of Natural Science
   Foundation of Hunan Province (Open Competition) (grant no.
   2021JC0002-06) , and The Scientific Research Program of FuRong
   Laboratory (no. 2024PT5104). We appreciate the support and suggestions
   from Pai Zheng in the BMJ Group. We thank Prof. Yuqing Eugene Chen
   (University of Michigan) for his insightful advice.
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TC 47
Z9 52
U1 28
U2 84
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 1550-4131
EI 1932-7420
J9 CELL METAB
JI Cell Metab.
PD APR 1
PY 2025
VL 37
IS 4
DI 10.1016/j.cmet.2024.12.005
EA APR 2025
PG 27
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA 1FJ4O
UT WOS:001463710600001
PM 39879982
DA 2026-05-27
ER

PT J
AU Purgatorio, R
   Boccarelli, A
   Pisani, L
   de Candia, M
   Catto, M
   Altomare, CD
AF Purgatorio, Rosa
   Boccarelli, Angelina
   Pisani, Leonardo
   de Candia, Modesto
   Catto, Marco
   Altomare, Cosimo D.
TI A Critical Appraisal of the Protective Activity of Polyphenolic
   Antioxidants against Iatrogenic Effects of Anticancer Chemotherapeutics
SO ANTIOXIDANTS
LA English
DT Review
DE polyphenols; chemotherapy adjuvants; oxidative stress; cardiac toxicity
ID DOXORUBICIN-INDUCED CARDIOTOXICITY; ELLAGIC ACID; DIETARY POLYPHENOLS;
   ANTHRACYCLINE CARDIOTOXICITY; MEDITERRANEAN DIET; OXIDATIVE STRESS;
   CURCUMA-LONGA; GALLIC ACID; CANCER; SALIDROSIDE
AB Polyphenolic compounds, encompassing flavonoids (e.g., quercetin, rutin, and cyanidin) and non-flavonoids (e.g., gallic acid, resveratrol, and curcumin), show several health-related beneficial effects, which include antioxidant, anti-inflammatory, hepatoprotective, antiviral, and anticarcinogenic properties, as well as the prevention of coronary heart diseases. Polyphenols have also been investigated for their counteraction against the adverse effects of common anticancer chemotherapeutics. This review evaluates the outcomes of clinical studies (and related preclinical data) over the last ten years, with a focus on the use of polyphenols in chemotherapy as auxiliary agents acting against oxidative stress toxicity induced by antitumor drugs. While further clinical studies are needed to establish adequate doses and optimal delivery systems, the improvement in polyphenols' metabolic stability and bioavailability, through the implementation of nanotechnologies that are currently being investigated, could improve therapeutic applications of their pharmaceutical or nutraceutical preparations in tumor chemotherapy.
C1 [Purgatorio, Rosa; Pisani, Leonardo; de Candia, Modesto; Catto, Marco; Altomare, Cosimo D.] Univ Bari Aldo Moro, Dept Pharm Pharmaceut Sci, Via E Orabona 4, I-70125 Bari, Italy.
   [Boccarelli, Angelina] Univ Bari Aldo Moro, Dept Precis & Regenerat Med & Ionian Area, Sch Med, Piazza Giulio Cesare 11, I-70124 Bari, Italy.
C3 Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari
   Aldo Moro
RP Altomare, CD (corresponding author), Univ Bari Aldo Moro, Dept Pharm Pharmaceut Sci, Via E Orabona 4, I-70125 Bari, Italy.
EM rosa.purgatorio@uniba.it; angelina.boccarelli@uniba.it;
   leonardo.pisani@uniba.it; modesto.decandia@uniba.it;
   marco.catto@uniba.it; cosimodamiano.altomare@uniba.it
RI ; BOCCARELLI, Angelina/AAM-4813-2020; Purgatorio, Rosa/ABH-3216-2020;
   PISANI, Leonardo/AAJ-1311-2021
OI ALTOMARE, Cosimo Damiano/0000-0001-5016-5805; CATTO,
   Marco/0000-0002-8411-304X; BOCCARELLI, Angelina/0000-0002-9514-2022;
   Purgatorio, Rosa/0000-0003-1002-5087; PISANI,
   Leonardo/0000-0002-4198-3897; de Candia, Modesto/0000-0002-4570-1981
FU Italian Ministry of Education, Universities and Research (PRIN)
   [2017RPHBCW_002]; Apulian Region "Research for Innovation (REFIN)"-POR
   PUGLIA [FESR-FSE 2014/2020, F88A1A13]
FX R.P.: A.B., M.C., and C.D.A. are part of the research network carrying
   out a project of the Italian Ministry of Education, Universities and
   Research (PRIN, Grant 201744BNST_004). L.P. is a member of the research
   unit of a project of the Italian Ministry of Education, Universities and
   Research (PRIN, Grant 2017RPHBCW_002). R.P. is a researcher supported by
   Apulian Region "Research for Innovation (REFIN)"-POR PUGLIA FESR-FSE
   2014/2020 (Project F88A1A13), and this publication is congruent with her
   research project.
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NR 117
TC 14
Z9 19
U1 0
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JAN
PY 2024
VL 13
IS 1
AR 133
DI 10.3390/antiox13010133
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA FW3L9
UT WOS:001148850500001
PM 38275658
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Wang, YS
   Zhou, SS
   Shen, CY
   Jiang, JG
AF Wang, Yan-Shuo
   Zhou, Si-Si
   Shen, Chun-Yan
   Jiang, Jian-Guo
TI Isolation and identification of four antioxidants from Rhodiola
   crenulata and evaluation of their UV photoprotection capacity in
   vitro
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Rhodiola crenulata; Antioxidant; Photoprotection; UV radiation; Skin
   aging
ID SKIN DAMAGE; POLYSACCHARIDES; IRRADIATION; KAEMPFEROL; KERATINOCYTES;
   POLYPHENOLS; RADIATION; APOPTOSIS; PROTECTS; ROOTS
AB Rhodiola crenulata has recently been reported to be able to attenuate radiation induced oxidative injury and improve skin homeostasis. The purpose of this research is to identify and evaluate the active constituents responsible for its anti-photoaging effects. Four ingredients, Salidroside, Arbutin, Kaempferol and Rhodiolinin were purified form R. crenulata and their antioxidant effects were tested. Further, the protective effects of the four compounds against UVB irradiation on ITSF and HaCaT cells were determined and the proinflammatory cytokines IL-6 and TNF-alpha were analyzed by the ELISA kits. Results showed that the four compounds could effectively improve UVB irradiation-induced cell apoptosis and regulate the production of inflammatory cytokines IL-6 and TNF-alpha. Kaempferol and arbutin exerted more powerful repairing capacities and played more significant role in reversing the abnormity of cytokines secretion in cell supernatant, indicating that the two compounds may be the more effective ingredients from R. crenulata to exert anti-photoaging function.
C1 [Wang, Yan-Shuo; Zhou, Si-Si; Shen, Chun-Yan; Jiang, Jian-Guo] South China Univ Technol, Coll Food & Bioengn, Guangzhou 510640, Peoples R China.
C3 South China University of Technology
RP Shen, CY; Jiang, JG (corresponding author), South China Univ Technol, Coll Food & Bioengn, Guangzhou 510640, Peoples R China.
EM 201610104045@mail.scut.edu.cn; jgjiang@scut.edu.cn
RI ; Shen, Chun-Yan/GZH-0001-2022
OI Jiang, Jian-Guo/0000-0002-3361-6149; 
FU Science and Technology Project of Guangzhou City, China [201604020150]
FX The authors gratefully acknowledge the financial support from the
   Science and Technology Project of Guangzhou City, China (201604020150).
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PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD MAR
PY 2020
VL 66
AR 103825
DI 10.1016/j.jff.2020.103825
PG 11
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA KT0NV
UT WOS:000518708200029
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Xu, LX
   Yan, LJ
   Huang, SP
AF Xu Lixin
   Yan Lijun
   Huang Songping
TI Ganoderic acid A against cyclophosphamide-induced hepatic toxicity in
   mice
SO JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
LA English
DT Article
DE cyclophosphamide (CP); ganoderic acid A (GAA); hepatotoxicity
ID INFLAMMATION; INJURY; TETRAMETHYLPYRAZINE; APOPTOSIS; RATS; THIOREDOXIN;
   SALIDROSIDE; ACTIVATION; CYSTEINE; CELLS
AB This study clarified the protective effect of ganoderic acid A (GAA) on cyclophosphamide (CP)-induced hepatotoxicity in mice. Hepatic injury mice were induced by a single intraperitoneal injection of CP (200mg/kg). The results showed that the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum and liver of the CP group mice were increased, and the levels of cytokines such as interleukin (IL)-1, IL-6, and tumor necrosis factor- in serum were increased. With the increase of the thioredoxin interaction protein (Txnip)/Trx/NF-kB pathway, the histological structure of the liver has significantly changed as well as apoptosis events. On the contrary, the levels of ALT, AST, and cytokines in serum and liver in mice have been improved after GAA administration. Furthermore, the protein levels of the Txnip/Trx/NF-kB pathway and apoptosis-related protein including Bax, Bcl-2, caspase-3, and -9 were restored by GAA. In conclusion, GAA can be used as an effective drug to improve the hepatotoxicity caused by CP.
C1 [Xu Lixin; Yan Lijun; Huang Songping] Nantong Univ, Nantong Peoples Hosp 3, Dept Hepatol, Nantong, Peoples R China.
C3 Nantong University
RP Xu, LX (corresponding author), Nantong Univ, Nantong Peoples Hosp 3, Nantong 226301, Peoples R China.
EM xlxwjp@126.com
RI lijun, yan/ADS-0663-2022
OI lijun, yan/0000-0002-5993-273X
FU Nantong Health Bureau Youth Project Fund [WQ2015032]
FX Nantong Health Bureau Youth Project Fund, Grant/Award Number: WQ2015032
CR [Anonymous], 2016, ELECT J QUALIT THEOR
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NR 21
TC 52
Z9 58
U1 0
U2 24
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1095-6670
EI 1099-0461
J9 J BIOCHEM MOL TOXIC
JI J. Biochem. Mol. Toxicol.
PD APR
PY 2019
VL 33
IS 4
AR e22271
DI 10.1002/jbt.22271
PG 5
WC Biochemistry & Molecular Biology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Toxicology
GA HY3LQ
UT WOS:000468028500007
PM 30506662
DA 2026-05-27
ER

PT J
AU Durazzo, A
   Lucarini, M
   Nazhand, A
   Coêlho, AG
   Souto, EB
   Arcanjo, DDR
   Santini, A
AF Durazzo, Alessandra
   Lucarini, Massimo
   Nazhand, Amirhossein
   Coelho, Angelica G.
   Souto, Eliana B.
   Arcanjo, Daniel D. R.
   Santini, Antonello
TI Rhodiola rosea: main features and its beneficial properties
SO RENDICONTI LINCEI-SCIENZE FISICHE E NATURALI
LA English
DT Article
DE Rhodiola rosea; Bioactive compounds; Biological properties; Literature
   quantitative research analysis approach; Technological prospecting
ID DOUBLE-BLIND; KAPPA-B; SALIDROSIDE; EXTRACT; PATHWAY; L.; FATIGUE;
   STRESS; MIGRATION; PLANTS
AB Medicinal plants have always been prescribed around the world with therapeutic purposes for various diseases and disorders related to their profile of biologically active substances and health-promoting effects. Meantime, Rhodiola rosea has been of particular importance among physicians, researchers and the general public. Accordingly, the present perspective aimed to explore the beneficial effects of this plant by focusing on in vitro and in vivo studies, and nutritional effects. The current work also provides a comprehensive analysis of the Rhodiola rosea studies in the literature throughout a quantitative literature research analysis approach. The literature search was carried out by means of the Scopus database to retrieve Rhodiola rosea-related publications. VOSviewer software (v.1.6.16, 2020) was used to extract and elaborate bibliometric data. 958 publications ranging from 1966 to 2021 were given by the literature search. Technological prospecting for patents was also assessed.
C1 [Durazzo, Alessandra; Lucarini, Massimo] CREA Res Ctr Food & Nutr, Via Ardeatina 546, I-00178 Rome, Italy.
   [Nazhand, Amirhossein] Sari Agr Sci & Nat Resource Univ, Dept Biotechnol, 9th Km Farah Abad Rd, Mazandaran 4818168984, Iran.
   [Coelho, Angelica G.; Arcanjo, Daniel D. R.] Univ Fed Piaui, Dept Biophys & Physiol, Lab Funct & Mol Studies Physiopharmacol LAFMOL, BR-64049550 Piaui, Brazil.
   [Souto, Eliana B.] Univ Porto, Fac Pharm, Dept Pharmaceut Technol, Rua Jorge Viterbo Ferreira 228, P-4050313 Porto, Portugal.
   [Santini, Antonello] Univ Napoli Federico II, Dept Pharm, Via D Montesano 49, I-80131 Naples, Italy.
C3 Consiglio per la Ricerca in Agricoltura e L'analisi Dell'economia
   Agraria (CREA); Universidade Federal do Piaui; Universidade do Porto;
   University of Naples Federico II
RP Durazzo, A; Lucarini, M (corresponding author), CREA Res Ctr Food & Nutr, Via Ardeatina 546, I-00178 Rome, Italy.
EM alessandra.durazzo@crea.gov.it; massimo.lucarini@crea.gov.it;
   nazhand.ah@gmail.com; angelicacoelho13@gmail.com;
   souto.eliana@gmail.com; daniel.arcanjo@ufpi.edu.br; asantini@unina.it
RI Arcanjo, Daniel/D-8851-2012; Souto, Eliana B/T-1645-2019; Lucarini,
   Massimo/AAL-9254-2020; Durazzo, Alessandra/AAN-4182-2020; Santini,
   Antonello/J-4923-2019; Nazhand, Amirhossein/C-4791-2018
OI Arcanjo, Daniel/0000-0001-7021-2744; Souto, Eliana
   B/0000-0002-9737-6017; Durazzo, Alessandra/0000-0002-7747-9107; 
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NR 76
TC 9
Z9 10
U1 2
U2 39
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 2037-4631
EI 1720-0776
J9 REND LINCEI-SCI FIS
JI Rend. Lincei.-Sci. Fis. Nat.
PD MAR
PY 2022
VL 33
IS 1
SI SI
BP 71
EP 82
DI 10.1007/s12210-022-01055-y
EA MAR 2022
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 0C9LC
UT WOS:000768117800001
DA 2026-05-27
ER

PT J
AU Liu, ZX
   Wang, WX
   Luo, J
   Zhang, YR
   Zhang, YS
   Gan, ZQ
   Shen, XF
   Zhang, Y
   Meng, XL
AF Liu, Zixuan
   Wang, Wenxiang
   Luo, Jie
   Zhang, Yingrui
   Zhang, Yunsen
   Gan, Zhiqiang
   Shen, Xiaofei
   Zhang, Yi
   Meng, Xianli
TI Anti-Apoptotic Role of Sanhuang Xiexin Decoction and Anisodamine in
   Endotoxemia
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE endotoxemia; anti-apoptosis; immunosuppression; herbal medicine;
   sanhuang xiexin decoction; anisodamine
ID NF-KAPPA-B; ACUTE KIDNEY INJURY; CELL APOPTOSIS; LYMPHOCYTE APOPTOSIS;
   RAT MODEL; LIPOPOLYSACCHARIDE; BAICALIN; SALIDROSIDE; STRESS; PREVENTS
AB Endotoxemia is characterized by initial uncontrollable inflammation, terminal immune paralysis, significant cell apoptosis and tissue injury, which can aggravate or induce multiple diseases and become one of the complications of many diseases. Therefore, anti-inflammatory and anti-apoptotic therapy is a valuable strategy for the treatment of endotoxemia-induced tissue injury. Traditional Chinese medicine exhibits great advantages in the treatment of endotoxemia. In this review, we have analyzed and summarized the active ingredients and their metabolites of Sanhuang Xiexin Decoction, a famous formula in endotoxemia therapy. We then have summarized the mechanisms of Sanhuang Xiexin Decoction against endotoxemia and its mediated tissue injury. Furthermore, silico strategy was used to evaluate the anti-apoptotic mechanism of anisodamine, a well-known natural product that widely used to improve survival in patients with septic shock. Finally, we also have summarized other anti-apoptotic natural products as well as their therapeutic effects on endotoxemia and its mediated tissue injury.
C1 [Liu, Zixuan; Wang, Wenxiang; Luo, Jie; Zhang, Yingrui; Gan, Zhiqiang; Zhang, Yi] Chengdu Univ Tradit Chinese Med, Ethn Med Acad Heritage Innovat Res Ctr, Chengdu, Peoples R China.
   [Liu, Zixuan; Wang, Wenxiang; Luo, Jie; Zhang, Yingrui; Zhang, Yunsen; Gan, Zhiqiang; Zhang, Yi] Chengdu Univ Tradit Chinese Med, Sch Ethn Med, Chengdu, Peoples R China.
   [Shen, Xiaofei] Hosp Chengdu Univ Tradit Chinese Med, TCM Regulating Metab Dis Key Lab Sichuan Prov, Chengdu, Peoples R China.
   [Meng, Xianli] Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Chengdu, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine; Chengdu University of Traditional
   Chinese Medicine; Chengdu University of Traditional Chinese Medicine
RP Zhang, Y (corresponding author), Chengdu Univ Tradit Chinese Med, Ethn Med Acad Heritage Innovat Res Ctr, Chengdu, Peoples R China.; Zhang, Y (corresponding author), Chengdu Univ Tradit Chinese Med, Sch Ethn Med, Chengdu, Peoples R China.; Meng, XL (corresponding author), Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Chengdu, Peoples R China.
EM zhangyi@cdutcm.edu.cn; xlm999@cdutcm.edu.cn
RI Wang, Wenxiang/JAO-4417-2023; Zhang, Yunsen/NKP-3243-2025; shen,
   xiaofei/LRT-1082-2024
OI Wang, Wenxiang/0000-0001-8797-1413; Zhang, Yunsen/0000-0003-3476-6728; 
FU National Natural Science Foundation of China [81773974]; National Key
   R&D program of China [2017YFC1703904]; Science and Technology Department
   of Sichuan Province [19SYXHZ0095, 2018JY0467]
FX This work was supported by the National Natural Science Foundation of
   China (81773974), the National Key R&D program of China
   (2017YFC1703904), the Science and Technology Department of Sichuan
   Province (19SYXHZ0095, 2018JY0467).
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NR 96
TC 17
Z9 19
U1 2
U2 40
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD APR 21
PY 2021
VL 12
AR 531325
DI 10.3389/fphar.2021.531325
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA RX1RU
UT WOS:000646999200001
PM 33967742
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Wani, TA
   Banat, F
AF Wani, Touseef Ahmed
   Banat, Fawzi
TI Nutraceutical versatility of Tyrosol: A review
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Tyrosol; Phenylethanoid; Nutraceutical potential in vitro; Bioactive
   properties in vivo; Quorum sensing properties
ID VIRGIN OLIVE OIL; GLOBAL CEREBRAL-ISCHEMIA; IN-VITRO;
   PHENOLIC-COMPOUNDS; OXIDATIVE STRESS; P-TYROSOL; CELLS; ANTIOXIDANT;
   SALIDROSIDE; METABOLISM
AB Tyrosol (TY) is a phenolic compound mainly reported from olive oil. Over the years, researchers worldwide have increased the exploration of TY, revealing multiple natural sources. TY demonstrates antioxidant and antiinflammatory properties by reducing reactive oxygen species, restoring antioxidant enzymes, and modulating inflammatory pathways. TY exhibits antidiabetic, antiobesity, and hepatoprotective effects via modulation of lipid metabolism, insulin sensitivity, adipogenesis, and gut microbiota. Through antioxidant, anti-inflammatory and gene-regulatory functions, TY contributes to respiratory protection, ameliorates ulcerative colitis, improves reproductive health, and enhances stress resilience. TY shows tumor-specific toxicity by inhibiting cell proliferation, inducing cell cycle arrest, and modulating cancer pathways. TY offers robust neuroprotection against ischemic and neurodegenerative insults. Furthermore, TY exhibits broad-spectrum antimicrobial activity by inhibiting quorum sensing-regulated virulence factors, biofilm formation, and mycotoxin biosynthesis without promoting antimicrobial resistance. These multifaceted effects underscore the therapeutic potential of TY for incorporation into functional foods and pharmacological formulations for combating chronic diseases.
C1 [Wani, Touseef Ahmed] Khalifa Univ Sci & Technol, Dept Chem & Petr Engn, POB 127788, Abu Dhabi, U Arab Emirates.
   [Banat, Fawzi] Khalifa Univ Sci & Technol, Food Secur & Technol Ctr, POB 127788, Abu Dhabi, U Arab Emirates.
C3 Khalifa University of Science & Technology; Khalifa University of
   Science & Technology
RP Wani, TA (corresponding author), Khalifa Univ Sci & Technol, Dept Chem & Petr Engn, POB 127788, Abu Dhabi, U Arab Emirates.; Banat, F (corresponding author), Khalifa Univ Sci & Technol, Food Secur & Technol Ctr, POB 127788, Abu Dhabi, U Arab Emirates.
EM wanitouseef24@gmail.com; fawzi.banat@ku.ac.ae
RI Wani, Touseef/A-1011-2016
FU Khalifa University of Science and Tech-nology, Abu Dhabi, United Arab
   Emirates [8474000593]
FX The authors are grateful to Khalifa University of Science and
   Tech-nology, Abu Dhabi, United Arab Emirates for supporting this
   research (8474000593) .
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NR 103
TC 1
Z9 1
U1 12
U2 16
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD SEP
PY 2025
VL 132
AR 106978
DI 10.1016/j.jff.2025.106978
EA SEP 2025
PG 13
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA 5TQ7A
UT WOS:001544061800002
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Liu, R
   Jiang, CH
   Zhao, ZZ
   Lv, YT
   Wang, GX
AF Liu, Rui
   Jiang, Cuihong
   Zhao, Zhizheng
   Lv, Yutong
   Wang, Gaoxing
TI Rosavin exerts an antitumor role and inactivates the MAPK/ERK pathway in
   small-cell lung carcinoma in vitro
SO ACTA PHARMACEUTICA
LA English
DT Article
DE small-cell lung cancer; rosavin; MEK; ERK
ID RHODIOLA-ROSEA; PHASE-III; CANCER; SALIDROSIDE; CISPLATIN; ETOPOSIDE;
   INDUCTION; EXTRACT; GROWTH
AB This study attempts to explore the function and mechanism of action of rosavin in small-cell lung cancer (SCLC) in vitro. The viability and clone formation of SCLC cells were assessed using cell counting kit-8 and colony formation assays, respectively. Apoptosis and cell cycle were detected using flow cytometry and cell cycle analysis, respectively. Wound healing and transwell assays were performed to evaluate the migration and invasion of SCLC cells. Besides, protein levels of p-ERK, ERK, p-MEK and MEK were determined using Western blot analysis. Rosavin repressed the viability and clone formation of SCLC cells, and promoted apoptosis and G(0)/G(1) arrest of SCLC cells. At the same time, rosavin suppressed migration and invasion of SCLC cells. Moreover, protein levels of p-ERK/ERK and p-MEK/MEK were decreased after rosavin addition in SCLC cells. Rosavin impaired malignant behaviors of SCLC cells, which may be associated with inhibition of the MAPK/ERK pathway in vitro.
C1 [Liu, Rui; Jiang, Cuihong; Zhao, Zhizheng; Lv, Yutong; Wang, Gaoxing] China Acad Chinese Med Sci, Guanganmen Hosp, Dept Oncol, South Campus, Beijing 102618, Peoples R China.
C3 Guang'anmen Hospital, CACMS; China Academy of Chinese Medical Sciences
RP Wang, GX (corresponding author), China Acad Chinese Med Sci, Guanganmen Hosp, Dept Oncol, South Campus, Beijing 102618, Peoples R China.
EM drruiliu@163.com
OI Jiang, Cuihong/0000-0002-1755-8073
FU National Natural Science Foundation of China [81703918]
FX This study was supported by the National Natural Science Foundation of
   China (81703918).
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NR 33
TC 4
Z9 4
U1 1
U2 7
PU SCIENDO
PI WARSAW
PA BOGUMILA ZUGA 32A, WARSAW, MAZOVIA, POLAND
SN 1330-0075
EI 1846-9558
J9 ACTA PHARMACEUT
JI Acta Pharm.
PD JUN 1
PY 2023
VL 73
IS 2
BP 269
EP 280
DI 10.2478/acph-2023-0015
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA J1RX5
UT WOS:001007464100008
PM 37307376
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Tang, B
   Guo, D
   Lin, X
   Yan, J
   Yang, HQ
   Li, H
AF Tang, Bin
   Guo, Dan
   Lin, Xia
   Yan, Jin
   Yang, Hongqin
   Li, Hui
TI Separation and Determination of Phenylpropanoid Glycosides in
   Rhodiola by Microemulsion Electrokinetic Chromatography
SO CURRENT PHARMACEUTICAL ANALYSIS
LA English
DT Article
DE Capillary electrophoresis; microemulsion electrokinetic chromatography;
   phenylpropanoid glycosides; rhodiola; rosarin; rosavin; rosin
ID PERFORMANCE LIQUID-CHROMATOGRAPHY; ROSEA EXTRACTS;
   CAPILLARY-ELECTROPHORESIS; ELECTROCHEMICAL DETECTION; INJECTION;
   SPECTROMETRY; DITERPENOIDS; SALIDROSIDE; ALKALOIDS; SAMPLES
AB A novel microemulsion electrokinetic chromatography (MEEKC) method for the simultaneous separation and quantitative determination of phenylpropanoid glycosides in Rhodiola L. was developed. The effects of many parameters influencing separation characteristics were optimized. Retention factor met rosarin<rosavin<rosin at the same 2-propanol concentration. Both selectivity and resolution of rosarin and rosavin increased with increasing 2-propanol content. The similar chemical structure led to a small difference in theoretical plates. The resolution of rosarin and rosavin showed greater improvements than rosavin and rosin with increasing buffer pH. According to the separation characteristics, the optimal running buffer was determined: 80 mmol/ L sodium dodecyl sulfate, 1.0% n-heptane, 7.5% 1-buatnol, 22.5% 2-propanol, and 10 mmol/ L sodium borate buffer at pH 9.25. Validation showed that this simple MEEKC method possesses feasible accuracy and precision. Furthermore, the developed method successfully quantified three phenylpropanoid glucosides in the Rhodiola rosea sample extracts and three oral liquids.
C1 [Tang, Bin; Guo, Dan; Lin, Xia; Yan, Jin; Yang, Hongqin; Li, Hui] Sichuan Univ, Coll Chem Engn, Chengdu 610064, Peoples R China.
C3 Sichuan University
RP Li, H (corresponding author), Sichuan Univ, Coll Chem Engn, Chengdu 610064, Peoples R China.
EM lihuilab@sina.com
RI /P-2270-2016
FU Science and Technology Department of Sichuan Province in China
   [2014JY0042]
FX This work was financially supported by Science and Technology Department
   of Sichuan Province in China (NO. 2014JY0042).
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NR 28
TC 1
Z9 1
U1 0
U2 30
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1573-4129
EI 1875-676X
J9 CURR PHARM ANAL
JI Curr. Pharm. Anal.
PY 2015
VL 11
IS 3
BP 224
EP 230
DI 10.2174/1573412911666150121231557
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CH6CU
UT WOS:000354124200009
DA 2026-05-27
ER

PT J
AU Panossian, A
   Hamm, R
   Kadioglu, O
   Wikman, G
   Efferth, T
AF Panossian, Alexander
   Hamm, Rebecca
   Kadioglu, Onat
   Wikman, Georg
   Efferth, Thomas
TI Synergy and antagonism of active constituents of ADAPT-232 on
   transcriptional level of metabolic regulation of isolated neuroglial
   cells
SO FRONTIERS IN NEUROSCIENCE
LA English
DT Article
DE pharmacogenomics; Rhodiola rosea; Schisandra chinensis; Eleutherococcus
   senticosus; ADAPT-232; salidroside; eleutheroside E; schizandrin
ID RHODIOLA-ROSEA EXTRACT; ESTROGEN-RECEPTOR-ALPHA; MITOCHONDRIAL
   ANTIOXIDANT STATUS; MESSENGER-RIBONUCLEIC-ACID; PROTEIN-COUPLED
   RECEPTORS; FOCAL CEREBRAL-ISCHEMIA; LONG-TERM POTENTIATION; ESTER
   TRANSFER PROTEIN; CENTRAL-NERVOUS-SYSTEM; SCHISANDRIN-B
AB Gene expression profiling was performed on the human neuroglial cell line T98G after treatment with adaptogen ADAPT-232 and its constituents extracts of Eleutherococcus senticosus root, Schisandra chinensis berry, and Rhodiola rosea root as well as several constituents individually, namely, eleutheroside E, schizandrin B, salidroside, triandrin, and tyrosol. A common feature for all tested adaptogens was their effect on G-protein-coupled receptor signaling pathways, i.e., cAMP, phospholipase C (PLC), and phosphatidylinositol signal transduction pathways. Adaptogens may reduce the cAMP level in brain cells by down-regulation of adenylate cyclase gene ADC2Y and up-regulation of phosphodiesterase gene PDE4D that is essential for energy homeostasis as well as for switching from catabolic to anabolic states and vice versa. Down-regulation of cAMP by adaptogens may decrease cAMP-dependent protein kinase A activity in various cells resulting in inhibition stress-induced catabolic transformations and saving of ATP for many ATP-dependant metabolic transformations. All tested adaptogens up-regulated the PLCB1 gene, which encodes phosphoinositide-specific PLC and phosphatidylinositol 3-kinases (PI3Ks), key players for the regulation of NE-kappa B-mediated defense responses. Other common targets of adaptogens included genes encoding ER alpha estrogen receptor (2.9-22.6 fold down-regulation), cholesterol ester transfer protein (5.1-10.6 fold down-regulation), heat shock protein Hsp70 (3.0-45.0 fold up-regulation), serpin peptidase inhibitor (neuroserpin), and 5-HT3 receptor of serotonin (2.2-6.6 fold down-regulation). These findings can be reconciled with the observed beneficial effects of adaptogens in behavioral, mental, and aging-associated disorders. Combining two or more active substances in one mixture significantly changes deregulated genes profiles: synergetic interactions result in activation of genes that none of the individual substances affected, while antagonistic interactions result in suppression some genes activated by individual substances. These interactions can have an influence on transcriptional control of metabolic regulation both on the cellular level and the level of the whole organism. Merging of deregulated genes array profiles and intracellular networks is specific to the new substance with unique pharmacological characteristics. Presumably, this phenomenon could be used to eliminate undesirable effects (e.g., toxic effects) and increase the selectivity of pharmacological intervention.
C1 [Panossian, Alexander; Wikman, Georg] Swedish Herbal Inst Res & Dev, SE-41262 Gothenburg, Sweden.
   [Hamm, Rebecca; Kadioglu, Onat; Efferth, Thomas] Johannes Gutenberg Univ Mainz, Inst Pharm & Biochem, Dept Pharmacol Biol, D-55122 Mainz, Germany.
C3 Johannes Gutenberg University of Mainz
RP Panossian, A (corresponding author), Swedish Herbal Inst Res & Dev, Grondalsgatan 11 A, SE-41262 Gothenburg, Sweden.
EM alexander.panossian@shi.se
RI ; Panossian, Alexander/AAK-8720-2021
OI Efferth, Thomas/0000-0002-2637-1681; Efferth,
   Thomas/0000-0002-3096-3292; Panossian, Alexander/0000-0002-8467-4525
FU Swedish Herbal Institute
FX This work was supported in part by the Swedish Herbal Institute
   (Alexander Panossian, Georg Wikman). We are indebted to Dr. Tolga
   Eichhorn (Department of Pharmaceutical Biology, Institute of Pharmacy
   and Biochemistry, University of Mainz, Mainz, Germany) for his
   scientific discussions and Karen Duffy (Cornell University, Ithaka, NY,
   USA) for critically reading the manuscript.
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NR 141
TC 60
Z9 68
U1 5
U2 26
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1662-453X
J9 FRONT NEUROSCI-SWITZ
JI Front. Neurosci.
PY 2013
VL 7
AR 16
DI 10.3389/fnins.2013.00016
PG 17
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA AW9HF
UT WOS:000346567300016
PM 23430930
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Noleto-Dias, C
   Wu, YQ
   Bellisai, A
   Macalpine, W
   Beale, MH
   Ward, JL
AF Noleto-Dias, Clarice
   Wu, Yanqi
   Bellisai, Alice
   Macalpine, William
   Beale, Michael H.
   Ward, Jane L.
TI Phenylalkanoid Glycosides (Non-Salicinoids) from Wood Chips of Salix
   triandra x dasyclados Hybrid Willow
SO MOLECULES
LA English
DT Article
DE phenylalkanoids; phenolic glycosides; Salix triandra; Salix dasyclados;
   chavicol; rosarin
ID PHENOLIC-COMPOUNDS; STRUCTURAL ELUCIDATION; BARK
AB Salix triandra (almond leaved willow) is an established crop, grown in coppicing regimes for basket-making materials. It is known as a source of non-salicinoid phenolic glycosides, such as triandrin and salidroside. A spontaneous natural hybrid of S. triandra and S. dasyclados was subjected to metabolite profiling by high resolution LC-MS, and 22 phenolic glycosides, including 18 that are new to the Salicaceae, were identified. Structures were determined by HPLC isolation and NMR methods. The hybridisation process has introduced novel chemistry into the Salix phenolic glycoside palette, in particular, the ability to generate disaccharide conjugates where the glycosyl group is further extended by a range of sugars, including apiose, rhamnose, xylose, and arabinose. Also of note is the appearance of chavicol derivatives, also not previously seen in Salix spp. The work demonstrates the plasticity of the phenolic glycoside biosynthetic pathway, and the potential to improve established crops such as S. triandra and S. dasyclados, via high-value metabolites, for both basketry and bioenergy markets.
C1 [Noleto-Dias, Clarice; Wu, Yanqi; Bellisai, Alice; Macalpine, William; Beale, Michael H.; Ward, Jane L.] Rothamsted Res, Harpenden AL5 2JQ, Herts, England.
   [Wu, Yanqi] Zhejiang Univ Technol, 18 Chaowang Rd, Hangzhou 310014, Zhejiang, Peoples R China.
C3 UK Research & Innovation (UKRI); Biotechnology and Biological Sciences
   Research Council (BBSRC); Rothamsted Research; Zhejiang University of
   Technology
RP Ward, JL (corresponding author), Rothamsted Res, Harpenden AL5 2JQ, Herts, England.
EM clarice.noleto-dias@rothamsted.ac.uk; wuyanqi@zjut.edu.cn;
   alice.bellisai@rothamsted.ac.uk; william.macalpine@rothamsted.ac.uk;
   mike.beale@rothamsted.ac.uk; jane.ward@rothamsted.ac.uk
RI Noleto-Dias, Clarice/AAW-3612-2020; Macalpine, William/HPF-3976-2023
OI Noleto-Dias, Clarice/0000-0003-0241-2888; Macalpine,
   William/0000-0001-9397-9243
FU Biotechnology and Biological Sciences Research Council (BBSRC) of the
   United Kingdom; Institute Strategic Programme grants "Tailoring Plant
   Metabolism" [BB/E/C/000I0410]; Cropping Carbon - BBSRC
   [BBS/E/C/00005199]; BBSRC [BBS/E/C/00005199, BBS/E/C/000I0410] Funding
   Source: UKRI; Biotechnology and Biological Sciences Research Council
   [BBS/E/C/000I0410, BBS/E/C/00005199] Funding Source: researchfish
FX Rothamsted Research receives grant-aided support from the Biotechnology
   and Biological Sciences Research Council (BBSRC) of the United Kingdom.
   The work in this study was supported by an Institute Strategic Programme
   grants "Tailoring Plant Metabolism" [BB/E/C/000I0410] and Cropping
   Carbon [BBS/E/C/00005199], funded by the BBSRC.
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NR 27
TC 16
Z9 18
U1 3
U2 19
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD MAR 2
PY 2019
VL 24
IS 6
AR 1152
DI 10.3390/molecules24061152
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA HU8AD
UT WOS:000465503800114
PM 30909533
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Karkeszová, K
   Antosová, M
   Potocká, EK
   Mastihuba, V
   Polakovic, M
AF Karkeszova, Klaudia
   Antosova, Monika
   Potocka, Elena Karnisova
   Mastihuba, Vladimir
   Polakovic, Milan
TI Medium engineering of phenylethanoid transfructosylation catalysed by
   yeast β-fructofuranosidase
SO BIOPROCESS AND BIOSYSTEMS ENGINEERING
LA English
DT Article
DE Tyrosol; Hydroxytyrosol; Transfructosylation; Yeast
   beta-fructofuranosidase; Deep eutectic solvents
ID ENZYMATIC-SYNTHESIS; INVERTASE; SUCROSE; HYDROLYSIS; SALIDROSIDE;
   SELECTIVITY; STABILITY; WATER
AB Tyrosol and hydroxytyrosol, by-products of olive oil production, are valuable substrates for enzymatic transglycosylation that can provide products with pharmaceutical potential. Phenylethanoid fructosides are produced from sucrose and phenylethanoids by the catalytic action of beta-fructofuranosidases. This work dealt with the potential of the most abundant beta-fructofuranosidase, baker's yeast invertase, for this bioconversion. The effects of sucrose and phenylethanoid concentrations were investigated with a focus on the selectivity of phenylethanoid transfructosylation and fructoside yields. For this purpose, initial rate and progress curve experiments were carried out for the initial (hydroxy)tyrosol and sucrose concentrations of 0.072-0.3 M and 1-2 M, respectively. Reaction courses exhibited either a maximum or plateau of fructoside yield in the range of about 10-18%. The addition of deep eutectic solvents was applied in the concentration range from 5 to 70% (v/v) to investigate the possibility of shifting the reaction equilibrium towards fructoside synthesis.
   [GRAPHICS]
C1 [Karkeszova, Klaudia; Antosova, Monika; Polakovic, Milan] Slovak Univ Technol Bratislava, Fac Chem & Food Technol, Inst Chem & Environm Engn, Dept Chem & Biochem Engn, Radlinskeho 9, Bratislava 81237, Slovakia.
   [Potocka, Elena Karnisova; Mastihuba, Vladimir] Slovak Acad Sci, Inst Chem, Dubrayska Cesta 9, Bratislava 84538, Slovakia.
C3 Slovak University of Technology Bratislava; Slovak Academy of Sciences;
   Institute of Chemistry, SAS
RP Polakovic, M (corresponding author), Slovak Univ Technol Bratislava, Fac Chem & Food Technol, Inst Chem & Environm Engn, Dept Chem & Biochem Engn, Radlinskeho 9, Bratislava 81237, Slovakia.
EM milan.polakovic@stuba.sk
RI Mastihuba, Vladimír/S-7938-2017; Polakovic, Milan/A-1080-2015; Antosova,
   Monika/HFZ-9237-2022; Karnišová Potocká, Elena/AAU-9718-2021
OI Mastihuba, Vladimír/0000-0003-2587-2553; Polakovic,
   Milan/0000-0003-0238-8996; Antosova, Monika/0000-0003-3671-9108;
   Karnišová Potocká, Elena/0000-0003-1546-4134
FU Slovak Research and Development Agency; Slovak Grant Agency for Science;
   VEGA;  [APVV-18-0188];  [1/0515/22]
FX AcknowledgementsThis work was supported by grants from the Slovak
   Research and Development Agency (Grant No. APVV-18-0188) and the Slovak
   Grant Agency for Science (Grant No. VEGA 1/0515/22).
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NR 47
TC 4
Z9 4
U1 2
U2 15
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1615-7591
EI 1615-7605
J9 BIOPROC BIOSYST ENG
JI Bioprocess. Biosyst. Eng.
PD FEB
PY 2023
VL 46
IS 2
BP 237
EP 249
DI 10.1007/s00449-022-02828-3
EA DEC 2022
PG 13
WC Biotechnology & Applied Microbiology; Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Engineering
GA 8H2TU
UT WOS:000893397400001
PM 36463528
DA 2026-05-27
ER

PT J
AU Harfouche, A
   Alata, W
   Leblanc, K
   Heslaut, G
   Figadère, B
   Maciuk, A
AF Harfouche, Abha
   Alata, Wael
   Leblanc, Karine
   Heslaut, Ghislain
   Figadere, Bruno
   Maciuk, Alexandre
TI Label-free LC-HRMS-based enzymatic activity assay for the detection of
   DDC, MAO and COMT inhibitors
SO JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
LA English
DT Article
DE COMT; MAO; Dopa decarboxylase; Screening; Parkinson
ID CATECHOL-O-METHYLTRANSFERASE; ST-JOHNS-WORT; RHODIOLA-ROSEA L.;
   PARKINSONS-DISEASE; B INHIBITORS; EXTRACT; MODEL; DECARBOXYLASE;
   SALIDROSIDE; DEFICIENCY
AB Pharmacological treatment of Parkinson's disease consists of a combined chemotherapy that mostly relies on levodopa (L-DOPA) administration together with inhibitors of dopa-decarboxylase (DDC), monoamine oxidase (MAO) and catechol-methyltransferase (COMT). Identification of inhibitors specifically targeting these enzymes is still a significative part of the development of new alternative antiparkinsonian drugs. Most of the available methods use measurement of enzymatic reactions through radioactive labeling, antibody-recognized products or coupled enzymatic assays. Mass spectrometry (MS) represents an interesting alternative approach as it allows direct and specific detection and quantification of enzymatic reactions. We describe the development of a simple, reliable, label-free assay based on high-resolution mass spectrometry (HRMS) for the detection and relative quantification of three different enzymatic reactions using non-isolated enzymes. The assay was applied both to reference drugs and plant crude extracts. This method can be used to detect hits in extracts libraries as well as determine relative IC50 of inhibitors.
C1 [Harfouche, Abha; Leblanc, Karine; Heslaut, Ghislain; Figadere, Bruno; Maciuk, Alexandre] Univ Paris Saclay, CNRS, BioCIS, F-92290 Chatenay Malabry, France.
   [Alata, Wael] Natl Res Council Canada, Human Hlth Therapeut Portfolio, Ottawa, ON K1A 0R6, Canada.
C3 Centre National de la Recherche Scientifique (CNRS); Universite Paris
   Saclay; National Research Council Canada
RP Maciuk, A (corresponding author), Univ Paris Saclay, CNRS, BioCIS, F-92290 Chatenay Malabry, France.
EM Abha.harfouche@hotmail.com; wael.alata@nrc-cnrc.gc.ca;
   karine.leblanc@universite-paris-saclay.fr;
   bruno.figadere@universite-paris-saclay.fr;
   alexandre.maciuk@universite-paris-saclay.fr
RI ; Maciuk, Alexane/J-2270-2018
OI ALATA, WAEL/0000-0003-4443-9173; Leblanc, Karine/0009-0002-9396-0870;
   Maciuk, Alexane/0000-0003-1436-6436
FU Ministry of Higher Education of Syria
FX This work was supported by Ministry of Higher Education of Syria (A. H.)
   .We thank Prof. Alain Gardier (Univ. Paris-Sud) , Prof. Erwan Poupon
   (Univ. Paris-Saclay) and Dr Sarah Karolak for fruitful discus-sions, Dr
   Guillaume Bernadat for graphics editing assistance, Dr San-drine Cojean
   and Stephanie Denis (Univ. Paris-Saclay) for access to some reagents,
   consumables and instrumentation, the IPSIT AnimEx platform for the gift
   of animals.
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NR 34
TC 6
Z9 7
U1 1
U2 18
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0731-7085
EI 1873-264X
J9 J PHARMACEUT BIOMED
JI J. Pharm. Biomed. Anal.
PD APR 1
PY 2022
VL 212
AR 114598
DI 10.1016/j.jpba.2022.114598
EA FEB 2022
PG 7
WC Chemistry, Analytical; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Pharmacology & Pharmacy
GA ZK2BW
UT WOS:000762800200005
PM 35152005
DA 2026-05-27
ER

PT J
AU Liu, ZB
   Fan, XY
   Wang, CW
   Ye, X
   Wu, CJ
AF Liu, Zi-bo
   Fan, Xin-yun
   Wang, Chen-wei
   Ye, Xun
   Wu, Chun-jie
TI Potentially active compounds that improve PAD through angiogenesis: A
   review
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Review
DE PAD; Natural products; Synthetic compounds; Angiogenesis; Hindlimb
   ischemia
ID ENDOTHELIAL PROGENITOR CELLS; PERIPHERAL ARTERY-DISEASE; PROMOTES
   ANGIOGENESIS; MYOCARDIAL-INFARCTION; RISK-FACTORS; MUSCLE; AUTOPHAGY;
   RECEPTOR; DIFFERENTIATION; INFLAMMATION
AB Peripheral arterial disease (PAD) has been historically neglected, which has resulted in a lack of effective drugs in clinical practice. However, with the increasing prevalence of diseases like atherosclerosis and diabetes, the incidence of PAD is rising and cannot be ignored. Researchers are exploring the potential of promoting angiogenesis through exogenous compounds to improve PAD. This paper focuses on the therapeutic effect of natural products (Salidroside, Astragaloside IV, etc.) and synthetic compounds (Cilostazol, Dapagliflozin, etc.). Specifically, it examines how they can promote autocrine secretion of vascular endothelial cells, enhance cell paracrine interactions, and regulate endothelial progenitor cell function. The activation of these effects may be closely related to PI3K, AMPK, and other pathways. Overall, these exogenous compounds have promising therapeutic potential for PAD. This study aims to summarize the potential active compounds, provide a variety of options for the search for drugs for the treatment of PAD, and bring light to the treatment of patients.
C1 [Liu, Zi-bo; Fan, Xin-yun; Wang, Chen-wei; Ye, Xun] Chengdu Univ Tradit Chinese Med, Sch Pharm, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China.
   [Wu, Chun-jie] Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Acad Interdiscipline, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine
RP Wu, CJ (corresponding author), Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Acad Interdiscipline, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China.
EM wuchunjie@cdutcm.edu.cn
RI ye, xun/JCD-9587-2023; liu, zibo/IYS-2200-2023
OI ye, xun/0000-0002-1321-0942; 
FU Sichuan Science and Technology Program [2021ZYCD012]
FX <BOLD> Sources of Funding </BOLD> This study was supported by the
   Sichuan Science and Technology Program (2021ZYCD012) .
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NR 99
TC 3
Z9 3
U1 1
U2 11
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD DEC
PY 2023
VL 168
AR 115634
DI 10.1016/j.biopha.2023.115634
EA OCT 2023
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA W6PF1
UT WOS:001092819900001
PM 37879211
OA gold
DA 2026-05-27
ER

PT J
AU Adeleke, BS
   Babalola, OO
AF Adeleke, Bartholomew Saanu
   Babalola, Olubukola Oluranti
TI Pharmacological Potential of Fungal Endophytes Associated with Medicinal
   Plants: A Review
SO JOURNAL OF FUNGI
LA English
DT Review
DE antibiotics; antimicrobial; fungal metabolites; medicinal plants;
   pharmacology
ID ARBUSCULAR MYCORRHIZAL FUNGI; SECONDARY METABOLITES; NATURAL-PRODUCTS;
   IDENTIFICATION; BIODIVERSITY; MECHANISMS; RESISTANCE; DIVERSITY;
   BACTERIA; AGENTS
AB Endophytic microbes are microorganisms that colonize the intracellular spaces within the plant tissues without exerting any adverse or pathological effects. Currently, the world population is facing devastating chronic diseases that affect humans. The resistance of pathogens to commercial antibiotics is increasing, thus limiting the therapeutic potential and effectiveness of antibiotics. Consequently, the need to search for novel, affordable and nontoxic natural bioactive compounds from endophytic fungi in developing new drugs with multifunction mechanisms to meet human needs is essential. Fungal endophytes produce invaluable bioactive metabolic compounds beneficial to humans with antimicrobial, anticancer, antidiabetic, anti-inflammatory, antitumor properties, etc. Some of these bioactive compounds include pestacin, taxol, camptothecin, ergoflavin, podophyllotoxin, benzopyran, isopestacin, phloroglucinol, tetrahydroxy-1-methylxanthone, salidroside, borneol, dibenzofurane, methyl peniphenone, lipopeptide, peniphenone etc. Despite the aforementioned importance of endophytic fungal metabolites, less information is available on their exploration and pharmacological importance. Therefore, in this review, we shall elucidate the fungal bioactive metabolites from medicinal plants and their pharmacological potential.
C1 [Adeleke, Bartholomew Saanu; Babalola, Olubukola Oluranti] North West Univ, Fac Nat & Agr Sci, Food Secur & Safety Niche Area, Private Bag X2046, ZA-2735 Mmabatho, South Africa.
C3 North West University - South Africa
RP Babalola, OO (corresponding author), North West Univ, Fac Nat & Agr Sci, Food Secur & Safety Niche Area, Private Bag X2046, ZA-2735 Mmabatho, South Africa.
EM olubukola.babalola@nwu.ac.za
RI Babalola, Olubukola Oluranti/Y-7564-2019; Adeleke,, Bartholomew
   Saanu/ACQ-1241-2022
OI Babalola, Olubukola Oluranti/0000-0003-4344-1909; Adeleke,, Bartholomew
   Saanu/0000-0001-7707-8816
FU National Research Foundation of South Africa [123634]
FX This study was funded by the National Research Foundation of South
   Africa (UID: 123634).
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NR 111
TC 93
Z9 121
U1 2
U2 86
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2309-608X
J9 J FUNGI
JI J. Fungi
PD FEB
PY 2021
VL 7
IS 2
AR 147
DI 10.3390/jof7020147
PG 16
WC Microbiology; Mycology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology; Mycology
GA QN7DR
UT WOS:000622615800001
PM 33671354
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Grech-Baran, M
   Syklowska-Baranek, K
   Krajewska-Patan, A
   Wyrwal, A
   Pietrosiuk, A
AF Grech-Baran, Marta
   Syklowska-Baranek, Katarzyna
   Krajewska-Patan, Anna
   Wyrwal, Anna
   Pietrosiuk, Agnieszka
TI Biotransformation of cinnamyl alcohol to rosavins by non-transformed
   wild type and hairy root cultures of Rhodiola kirilowii
SO BIOTECHNOLOGY LETTERS
LA English
DT Article
DE Biotransformation; Cinnamyl alcohol; Hairy root culture; Non-transformed
   wild type root culture; Rhodiola kirilowii; Rosavin; Rosarin
ID SALIDROSIDE PRODUCTION; ROSEA; EXTRACTS; TYROSOL
AB Non-transformed wild type (NTWT) and hairy root cultures of Rhodiola kirilowii were grown in medium supplemented with 2.5 mM cinnamyl alcohol as a precursor and/or sucrose (1 %) on the day of inoculation or on the 14th day of culture. Rosarin, rosavin, and rosin were produced by NTWT root culture but only rosarin and rosavin by hairy roots. Approximately 80 and 95 % of the glycosides were released into the medium for NTWT and hairy root cultures, respectively. The highest rosavin yield, 505 +/- A 106 mg/l, was in hairy root culture when cinnamyl alcohol was applied on the day of inoculation with the addition of sucrose on the 14th day of culture. For rosin production, supplementation with cinnamyl alcohol alone on day 14 was more favourable with the highest amount 74 +/- A 10 mg/l in NTWT root culture. Only traces of rosarin were detected.
C1 [Grech-Baran, Marta; Syklowska-Baranek, Katarzyna; Wyrwal, Anna; Pietrosiuk, Agnieszka] Med Univ Warsaw, Fac Pharm, Dept Biol & Pharmaceut Bot, PL-02097 Warsaw, Poland.
   [Krajewska-Patan, Anna] Inst Nat Fibres & Med Plants, PL-61707 Poznan, Poland.
C3 Medical University of Warsaw; Institute of Natural Fibres & Medicinal
   Plants
RP Grech-Baran, M (corresponding author), Med Univ Warsaw, Fac Pharm, Dept Biol & Pharmaceut Bot, Banacha 1 St, PL-02097 Warsaw, Poland.
EM mgrech@wum.edu.pl
RI Sykłowska-Baranek, Katarzyna/U-4650-2018; Pietrosiuk,
   Agnieszka/A-1320-2012
OI Sykłowska-Baranek, Katarzyna/0000-0002-9150-7872; Grech-Baran,
   Marta/0000-0002-3095-8944; Pietrosiuk, Agnieszka/0000-0001-7165-5336
FU Medical University of Warsaw [FW21/PM31D/12]
FX This study was supported by a research grant from the Young Scientists
   Program of the Medical University of Warsaw (FW21/PM31D/12).
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PU SPRINGER
PI DORDRECHT
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PD MAR
PY 2014
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BP 649
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DI 10.1007/s10529-013-1401-5
PG 8
WC Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology
GA AD6EX
UT WOS:000333349300029
PM 24190481
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Ha, H
   Shim, KS
   Kim, T
   An, H
   Lee, CJ
   Lee, KJ
   Ma, JY
AF Ha, Hyunil
   Shim, Ki-Shuk
   Kim, Taesoo
   An, Hyosun
   Lee, Chung-Jo
   Lee, Kwang Jin
   Ma, Jin Yeul
TI Water Extract of Acer tegmentosum Reduces Bone Destruction by
   Inhibiting Osteoclast Differentiation and Function
SO MOLECULES
LA English
DT Article
DE Acer tegmentosum; osteoclast; bone; RANKL
ID NF-KAPPA-B; IN-VIVO; C-FOS; BLOCKS OSTEOCLASTOGENESIS; SIGNALING
   PATHWAY; NFATC1 INDUCTION; ETHANOL EXTRACT; NUCLEAR-FACTOR; RANKL;
   SALIDROSIDE
AB The stem of Acer tegmentosum has been widely used in Korea for the treatment of hepatic disorders. In this study, we investigated the bone protective effect of water extract of the stem of Acer tegmentosum (WEAT). We found that WEAT inhibits osteoclast differentiation induced by receptor activator of nuclear factor-kappa B ligand (RANKL), an essential cytokine for osteoclast differentiation. In osteoclast precursor cells, WEAT inhibited RANKL-induced activation of JNK, NF-kappa B, and cAMP response element-binding protein, leading to suppression of the induction of c-Fos and nuclear factor of activated T cells cytoplasmic 1, key transcription factors for osteoclast differentiation. In addition, WEAT inhibited bone resorbing activity of mature osteoclasts. Furthermore, the oral administration of WEAT reduced RANKL-induced bone resorption and trabecular bone loss in mice. Taken together, our study demonstrates that WEAT possesses a protective effect on bone destruction by inhibiting osteoclast differentiation and function.
C1 [Ha, Hyunil; Shim, Ki-Shuk; Kim, Taesoo; An, Hyosun; Lee, Chung-Jo; Lee, Kwang Jin; Ma, Jin Yeul] Korea Inst Oriental Med, KM Based Herbal Drug Dev Grp, Taejon 305811, South Korea.
C3 Korea Institute of Oriental Medicine (KIOM)
RP Ma, JY (corresponding author), Korea Inst Oriental Med, KM Based Herbal Drug Dev Grp, Taejon 305811, South Korea.
EM jyma@kiom.re.kr
FU Korea Institute of Oriental Medicine, Ministry of Science, ICT and
   Future Planning, Republic of Korea [K14050]
FX This work was supported by a grant (K14050) from the Korea Institute of
   Oriental Medicine, Ministry of Science, ICT and Future Planning,
   Republic of Korea.
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NR 44
TC 25
Z9 28
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD APR
PY 2014
VL 19
IS 4
BP 3940
EP 3954
DI 10.3390/molecules19043940
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA AH4HK
UT WOS:000336087800007
PM 24694651
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Shen, J
   Liu, PF
   Zhang, B
   Ye, BC
   Xu, SQ
   Su, WK
   Chu, XH
AF Shen, Jian
   Liu, Pengfu
   Zhang, Bin
   Ye, Bangce
   Xu, Shunqing
   Su, Weike
   Chu, Xiaohe
TI Expanding the application of tyrosine: engineering microbes for the
   production of tyrosine and its derivatives
SO FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
LA English
DT Review
DE aromatic compounds; tyrosine; biomanufacturing; microbial fermentation;
   metabolic engineering
ID CAFFEIC ACID PRODUCTION; ESCHERICHIA-COLI; BIOTECHNOLOGICAL PRODUCTION;
   L-DOPA; SALVIANIC ACID; SKIN COLOR; PHENYLALANINE; OPTIMIZATION; GENOME;
   FERMENTATION
AB Aromatic compounds are widely used in the fields of medicine, chemical industry, and food, with a considerable market size. Tyrosine, an aromatic amino acid, boasts not only a wide range of applications but also serves as a valuable precursor for synthesizing a diverse array of high-value aromatic compounds. Amid growing concerns over environmental and resource challenges, the adoption of green, clean, and sustainable biotechnology for producing aromatic compounds is gaining increasing recognition as a viable alternative to traditional chemical synthesis and plant extraction methods. This article provides an overview of the current status of tyrosine biomanufacturing and explores the methods for generating derivatives, including resveratrol, levodopa, p-coumaric acid, caffeic acid, zosteric acid, tyrosol, hydroxytyrosol, tanshinol, naringenin, eriodictyol, and salidroside, using tyrosine as a primary raw material. Furthermore, this review examines the current challenges and outlines future directions for microbial fermentation for the production of tyrosine and its derivatives.
C1 [Shen, Jian; Liu, Pengfu; Xu, Shunqing; Su, Weike; Chu, Xiaohe] Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg, Green Pharmaceut, Hangzhou 310014, Zhejiang, Peoples R China.
   [Zhang, Bin] Jiangxi Agr Univ, Coll Biosci & Bioengn, Nanchang, Jiangxi, Peoples R China.
   [Ye, Bangce] East China Univ Sci & Technol, Shanghai, Peoples R China.
C3 Zhejiang University of Technology; Jiangxi Agricultural University; East
   China University of Science & Technology
RP Su, WK; Chu, XH (corresponding author), Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg, Green Pharmaceut, Hangzhou 310014, Zhejiang, Peoples R China.
EM suweike@zjut.edu.cn; chuxhe@zjut.edu.cn
RI Peijie, Zou/AAG-7580-2019
FU National Key Research and Development Program of China [2023YFA0914200];
   National Natural Science Foundation of China [32360021]; Major
   Discipline Academic and Technical Leaders Training Program of Jiangxi
   Province [20212BCJ23012]
FX The author(s) declare that financial support was received for the
   research and/or publication of this article. This work was supported by
   the National Key Research and Development Program of China (No.
   2023YFA0914200), National Natural Science Foundation of China (No.
   32360021), and Major Discipline Academic and Technical Leaders Training
   Program of Jiangxi Province (No. 20212BCJ23012).
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NR 100
TC 4
Z9 5
U1 15
U2 31
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-4185
J9 FRONT BIOENG BIOTECH
JI Front. Bioeng. Biotechnol.
PD APR 24
PY 2025
VL 13
AR 1519764
DI 10.3389/fbioe.2025.1519764
PG 13
WC Biotechnology & Applied Microbiology; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Engineering
GA 2IJ6B
UT WOS:001483377000001
PM 40343203
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Chen, DJ
   Fan, JT
   Wang, P
   Zhu, LY
   Jin, Y
   Peng, Y
   Du, SH
AF Chen, Danjun
   Fan, Junting
   Wang, Peng
   Zhu, Lanying
   Jin, Yang
   Peng, Yan
   Du, Shuhu
TI Isolation, identification and antioxidative capacity of water-soluble
   phenylpropanoid compounds from Rhodiola crenulata
SO FOOD CHEMISTRY
LA English
DT Article
DE Rhodiola crenulata; High-speed counter-current chromotography;
   Semi-preparative high-performance liquid chromatography; Identification;
   Antioxidative activity
ID COUNTER-CURRENT CHROMATOGRAPHY; ROSEA; CONSTITUENTS; EXTRACT;
   SALIDROSIDE; GLYCOSIDES; MEDICINES; ROOTS; SACRA; DRUG
AB Six water-soluble phenylpropanoid compounds obtained from Rhodiola crenulata (R. crenulata) were fractionated by high-speed counter-current chromatography (HSCCC), and purified by semi-preparative high-performance liquid chromatography (Semi-prep HPLC). The purities of the six compounds were all above 98.0% and their structures were identified by spectroscopic methods. Among them, a new compound, 2-(4-hydroxyphenyl)-ethyl-O-beta-D-glucopyranosyl-6-O-beta-D-glucopyranoside (1), together with two known phenylpropanoids, p-hydroxyphenacyl-beta-D-glucopyranoside (3) and picein (4) were isolated from R. crenulata for the first time. Meanwhile, the contents of six isolated ingredients from the crude extract of R. crenulata had been simultaneously detected, with satisfactory results. Furthermore, the antioxidant activities of the six compounds were accessed by measuring the radical scavenging activity against 2,2-diphenyl-1-picrylhydrazy (DPPH), and four compounds exhibited potent antioxidative activity. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Chen, Danjun; Fan, Junting; Wang, Peng; Zhu, Lanying; Jin, Yang; Peng, Yan; Du, Shuhu] Nanjing Med Univ, Sch Pharm, Nanjing 210029, Jiangsu, Peoples R China.
C3 Nanjing Medical University
RP Du, SH (corresponding author), Nanjing Med Univ, Sch Pharm, Nanjing 210029, Jiangsu, Peoples R China.
EM shuhudu@njmu.edu.cn
RI peng, yan/PDX-1705-2025
FU Specialized Research Fund for the Doctoral Program of Higher Education
   of China [20113234110001]; National Natural Science Foundation of China
   [21075066]
FX This work is supported by the Specialized Research Fund for the Doctoral
   Program of Higher Education of China (No. 20113234110001) and the
   National Natural Science Foundation of China (No. 21075066). The authors
   gratefully appreciate the assistance of Professor Dongjun Chen for his
   excellent technical support.
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SN 0308-8146
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PD OCT 15
PY 2012
VL 134
IS 4
BP 2126
EP 2133
DI 10.1016/j.foodchem.2012.04.011
PG 8
WC Chemistry, Applied; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Food Science & Technology; Nutrition & Dietetics
GA 966TH
UT WOS:000305859800055
PM 23442665
DA 2026-05-27
ER

PT J
AU Tsvetov, N
   Paukshta, O
   Fokina, N
   Volodina, N
   Samarov, A
AF Tsvetov, Nikita
   Paukshta, Oksana
   Fokina, Nadezhda
   Volodina, Natalia
   Samarov, Artemiy
TI Application of Natural Deep Eutectic Solvents for Extraction of
   Bioactive Components from Rhodiola rosea (L.)
SO MOLECULES
LA English
DT Article
DE natural deep eutectic solvents; Rhodiola rosea (L; );
   ultrasound-assisted extraction; antibacterial activity
ID MICROWAVE-ASSISTED EXTRACTION; SALIDROSIDE
AB Rhodiola rosea (L.) is a valuable source of nutrients. Nutrients have adaptogenic, immunostimulating, nootropic, anti-inflammatory and anti-cancer properties. Natural deep eutectic solvents (NADES) consisting of choline chloride and malonic, malic, tartaric or citric acids have been first used to extract biologically active substances from R. rosea. The total content of polyphenols has been determined by the Folin-Ciocalteu method for all extracts. Antioxidant activity has been determined by the phosphomolybdate method, and antiradical activity has been determined by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. Rosavin concentration has been determined by high-performance liquid chromatography (HPLC). Extraction kinetics has been evaluated regarding the effectiveness of NADES with each other and with reference solvents (water and 50% ethanol) has been made. Extraction conditions have been optimized according to the Box-Behnken design of the experiment. The optimal parameters of the extraction process have been established. The antibacterial activity of NADES-based extracts against bacterial cultures of Micrococcus luteus, Pseudomonas fluorescens, and Bacillus subtilis has been studied.
C1 [Tsvetov, Nikita] Russian Acad Sci, Kola Sci Ctr, Subdiv Fed Res Ctr, Tananaev Inst Chem & Technol Rare Elements & Miner, Akademgorodok 26a, Apatity 184209, Russia.
   [Paukshta, Oksana] Murmansk State Tech Univ, Chem Dept, Sportivnaja Str 13, Murmansk 183010, Russia.
   [Fokina, Nadezhda] Russian Acad Sci, Kola Sci Ctr, Subdiv Fed Res Ctr, Inst North Ind Ecol Problems, Akademgorodok 14a, Apatity 184209, Russia.
   [Volodina, Natalia; Samarov, Artemiy] St Petersburg State Univ, Inst Chem, Dept Chem Thermodynam & Kinet, Univ Skiy Prosp 26, St Petersburg 198504, Russia.
C3 Russian Academy of Sciences; Kola Science Centre of the Russian Academy
   of Sciences; Tananaev Institute of Chemistry, Kola Science Centre of the
   Russian Academy of Sciences; Russian Academy of Sciences; Kola Science
   Centre of the Russian Academy of Sciences; Institute of North Industrial
   Ecology Problems, Kola Science Centre of the Russian Academy of
   Sciences; Saint Petersburg State University
RP Tsvetov, N (corresponding author), Russian Acad Sci, Kola Sci Ctr, Subdiv Fed Res Ctr, Tananaev Inst Chem & Technol Rare Elements & Miner, Akademgorodok 26a, Apatity 184209, Russia.
EM tsvet.nik@mail.ru
RI Samarov, Artemiy/I-7156-2013; Tsvetov, Nikita/I-2623-2013; Volodina,
   Natalia/AAD-2174-2022; Fokina, Nadezhda/S-4421-2018
OI Samarov, Artemiy/0000-0002-9385-1335; 
FU Russian Science Foundation [22-26-20114] Funding Source: Medline
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NR 25
TC 25
Z9 27
U1 4
U2 58
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD JAN
PY 2023
VL 28
IS 2
AR 912
DI 10.3390/molecules28020912
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 7Z6TD
UT WOS:000915688600001
PM 36677969
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhang, ZX
   Song, XF
   Du, XY
   Cui, Y
   Dai, JS
AF Zhang, Zhenxing
   Song, Xiaofeng
   Du, Xiaoyuan
   Cui, Yu
   Dai, Jishou
TI Protective effect of tyrosol on apoptosis in PC12 cell induced by
   paraquat
SO AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY
LA English
DT Article
DE Tyrosol; PC12 cell; paraquat; protective effect
ID ENVIRONMENTAL RISK-FACTORS; RHODIOLA-ROSEA EXTRACT; PARKINSONS-DISEASE;
   OXIDATIVE STRESS; P-TYROSOL; EXPRESSION; RATS; NEUROTOXICITY;
   SALIDROSIDE; INHIBITION
AB The protective effect of tyrosol on apoptosis in PC12 cell induced by paraquat (PQ) was studied. The PC12 cell was cultured in RPMI-1640 medium supplemented with 10% newborn calf serum at 37 degrees C in a 5% CO2 incubator. 800 mu m of PQ solution was added to establish an oxidative-stress injury model in vitro. The protective effect of tyrosol was evaluated by using this model. We compared the lactate dehydrogenase (LDH) release rate and malondialdehyde (MDA) content of PC12 cells in different treatment group. The cell apoptosis was detected by using flow cytometry (FCM) and the cell proliferation by using 5-diphenyltetrazolium (MTT) assay. The results showed that pretreatment with tyrosol could improve cell growth and proliferation in a concentration dependent manner, reduce the release of LDH and MDA content, suppress the PQ-induced apoptosis of PC12 cells. Therefore, these results suggested that tyrosol possessed protective activity of PC12 cell's injury by PQ in vitro.
C1 [Zhang, Zhenxing; Cui, Yu; Dai, Jishou] Liaoning Med Univ, Dept Neurosurg, Affiliated Hosp 1, Jinzhou 121001, Peoples R China.
   [Song, Xiaofeng] Liaoning Med Univ, Dept Histol & Embryol, Jinzhou 121001, Peoples R China.
   [Du, Xiaoyuan] Liaoning Med Univ, Dept Pathol, Affiliated Hosp 1, Jinzhou 121001, Peoples R China.
C3 Jinzhou Medical University; Jinzhou Medical University; Jinzhou Medical
   University
RP Zhang, ZX (corresponding author), Liaoning Med Univ, Dept Neurosurg, Affiliated Hosp 1, Jinzhou 121001, Peoples R China.
EM tangf66@126.com
RI Song, Xiaofeng/AAP-4087-2020
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NR 36
TC 1
Z9 1
U1 0
U2 13
PU ACADEMIC JOURNALS
PI VICTORIA ISLAND
PA P O BOX 5170-00200 NAIROBI, VICTORIA ISLAND, LAGOS 73023, NIGERIA
SN 1996-0816
J9 AFR J PHARM PHARMACO
JI Afr. J. Pharm. Pharmacol.
PD AUG
PY 2012
VL 6
IS 29
BP 2224
EP 2228
DI 10.5897/AJPP12.396
PG 5
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 994YX
UT WOS:000307972900007
OA gold
DA 2026-05-27
ER

PT J
AU Yuan, M
   Nguyen, TTT
   Gibb, AJ
   Xian, YF
   Xu, HX
AF Yuan, Man
   Nguyen, Trinh Thach Thi
   Gibb, Alasdair J.
   Xian, Yan-Fang
   Xu, Hong-Xi
TI Potential of phytochemicals in the treatment of Alzheimer disease by
   modulating lysosomal dysfunction: a systematic review
SO CHINESE MEDICINE
LA English
DT Review
DE Alzheimer disease; Lysosomes; Phytochemicals; Autophagy; Phagocytosis
ID OXIDATIVE STRESS; TANSHINONE IIA; A-BETA; AUTOPHAGY; INFLAMMATION; TAU;
   CROCIN; MODEL
AB Alzheimer disease (AD) is a primary international health dilemma, especially in elderly populations, due to its progressive nature and its adverse cognitive impact. The dysfunction of lysosomes, which impairs protein degradation and leads to toxic accumulation in neurons, is a pivotal factor in AD. We explore phytochemicals that specifically target lysosomal dysfunction via the activation of autophagy, phagocytosis, and lysosome function, exhibiting anti-inflammatory and antioxidant properties. This study involves extracting and evaluating phytochemicals by exploring multiple databases, Google Scholar, PubMed, the Science Citation Index Expanded (SCIE), and the China National Knowledge Infrastructure (CNKI), integrating contemporary biochemical evidence with TCM principles-highlighting the interconnected roles of deficiency, stasis, and phlegm-to provide a comprehensive therapeutic framework. Key phytochemicals-magnolol, trehalose, and salidroside- demonstrate notable promise in enhancing lysosomal function, reducing amyloid beta accumulation, and improving cognitive outcomes. Addressing traditional theory and modern science, we underline the potential for future research by clarifying the mechanisms of compounds and their effectiveness, which may delay the disease process.
C1 [Yuan, Man; Nguyen, Trinh Thach Thi; Xu, Hong-Xi] Shanghai Univ Tradit Chinese Med, Sch Pharm, 1200 Cailun Rd, Shanghai 201203, Peoples R China.
   [Yuan, Man; Nguyen, Trinh Thach Thi; Xu, Hong-Xi] Shanghai Coll TCM New Drug Discovery, Engn Res Ctr, Shanghai 201203, Peoples R China.
   [Gibb, Alasdair J.] UCL, Dept Neurosci Physiol & Pharmacol, London, England.
   [Xian, Yan-Fang] Chinese Univ Hong Kong, Fac Med, Sch Chinese Med, Shatin, Hong Kong, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; University of
   London; University College London; Chinese University of Hong Kong
RP Xu, HX (corresponding author), Shanghai Univ Tradit Chinese Med, Sch Pharm, 1200 Cailun Rd, Shanghai 201203, Peoples R China.; Xu, HX (corresponding author), Shanghai Coll TCM New Drug Discovery, Engn Res Ctr, Shanghai 201203, Peoples R China.; Xian, YF (corresponding author), Chinese Univ Hong Kong, Fac Med, Sch Chinese Med, Shatin, Hong Kong, Peoples R China.
EM lisaxian@cuhk.edu.hk; xuhongxi88@gmail.com
RI Xian, Yan-Fang/AAA-6876-2020; Xu, Hongxi/AAC-2799-2020; Gibb,
   Alasdair/AAL-1605-2020
OI Xu, Hongxi/0000-0001-6238-4511; Gibb, Alasdair/0000-0002-2145-1615
FU National Natural Science Foundation of China
FX We want to acknowledge the support of our institution and resources.
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NR 212
TC 4
Z9 4
U1 4
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-8546
J9 CHIN MED-UK
JI Chin. Med.
PD SEP 1
PY 2025
VL 20
IS 1
AR 138
DI 10.1186/s13020-025-01204-z
PG 42
WC Integrative & Complementary Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; Pharmacology & Pharmacy
GA 6WO9C
UT WOS:001563740000005
PM 40890872
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Chen, RS
   Zhang, YX
   Patel, N
   Wu, KD
   Li, MM
   Mo, XM
   Yang, ZC
AF Chen, Runsen
   Zhang, Yuxi
   Patel, Nishant
   Wu, Kede
   Li, Manman
   Mo, Xuming
   Yang, Zhaocong
TI CARD9 mediated MAPK/NF-κB signal pathway participates in the
   pathophysiological process of septic hepatitis: The role of tiliroside
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE CARD9; Septic hepatitis; MAPK; NF-kappa B
ID ISCHEMIA-REPERFUSION INJURY; ACUTE LUNG INJURY; SALIDROSIDE; SEPSIS;
   MODEL; RATS
AB The purpose of the present study was to search for biomarker and effective treatment measures for septic hepatitis. Lipopolysaccharide (LPS) was used to establish septic hepatitis (SH) model in vivo and in vitro. Proteomics, immunoprecipitation, molecular docking techniques, and CARD9 knockout (KO) mice and silence Chang liver Cell (CLC) were used to search for biomarker and possible treatment targets and treatment measures for SH. 46 differentially expressed proteins were found in the liver tissues of sepsis mice, among which CARD9 changed most. CARD9 KO and silence significantly relieved sepsis induced SH in vivo and in vitro. Tiliroside (TIS), an effective component of Buddleja officinalis Maxim, significantly improved SH by regulating CARD9 mediated MAPK/NF-kappa B signal pathway. In conclusion, CARD9 may be the important molecular targets for SH. TIS could protect SH via CARD9 mediated MAPK/NF-kappa B signal pathway. The findings provide a new treatment target for SH and a potential treatment measure.
C1 [Chen, Runsen; Zhang, Yuxi; Patel, Nishant; Wu, Kede; Mo, Xuming; Yang, Zhaocong] Nanjing Med Univ, Dept Cardiothorac Surg, Childrens Hosp, Nanjing 210008, Peoples R China.
   [Li, Manman] China Pharmaceut Univ, Sch Life Sci & Technol, Nanjing 210008, Peoples R China.
C3 Nanjing Medical University; China Pharmaceutical University
RP Mo, XM; Yang, ZC (corresponding author), Nanjing Med Univ, Dept Cardiothorac Surg, Childrens Hosp, Nanjing 210008, Peoples R China.
EM mohsuming15@njmu.edu.cn; yangzhaocong34@126.com
RI Patel, Nishant/AAT-1604-2021; Yang, Zhaocong/IWM-0733-2023
OI Patel, Nishant/0000-0002-2573-7469; 
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NR 18
TC 4
Z9 4
U1 0
U2 10
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD NOV
PY 2023
VL 124
AR 110275
DI 10.1016/j.intimp.2023.110275
EA SEP 2023
PN B
PG 9
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA W1EB0
UT WOS:001089116800001
PM 37741127
DA 2026-05-27
ER

PT J
AU Zhou, W
   Bi, HP
   Zhuang, YB
   He, QL
   Yin, H
   Liu, T
   Ma, YH
AF Zhou, Wei
   Bi, Huiping
   Zhuang, Yibin
   He, Qinglin
   Yin, Hua
   Liu, Tao
   Ma, Yanhe
TI Production of Cinnamyl Alcohol Glucoside from Glucose in
   Escherichia coli
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE cinnamyl alcohol; rosin; Rhodiola rosea; E. coli; biosynthesis; UGT73B6;
   UGT73C5
ID RHODIOLA-ROSEA L.; UDP-GLUCOSYLTRANSFERASE; ARABIDOPSIS-THALIANA;
   MICROBIAL-PRODUCTION; LIGNIN BIOSYNTHESIS; AROMATIC-COMPOUNDS;
   SALIDROSIDE; GLYCOSYLTRANSFERASES; CINNAMALDEHYDE; SACHALINENSIS
AB Rosin, a cinnamyl alcohol glucoside, is one of the important ingredients in Rhodiola rosea, which is a valuable medicinal herb used for centuries. Rosin displayed multiple biological activities. The traditional method for producing rosin and derivatives is direct extraction from Rhodiola rosea, which suffers from limited availability of natural resources and complicated purification procedure. This work achieved de novo biosynthesis of rosin in Escherichia coli. First, a biosynthetic pathway of aglycon cinnamyl alcohol from phenylalanine was constructed. Subsequently, the UGT genes from Rhodiola sachalinensis (UGT73B6) or Arabidopsis thaliana (UGT73C5) were introduced into the above recombinant E. coli strain to produce rosin. Then the phenylalanine metabolic pathway of E. coli was optimized by genetic manipulation, and the production of rosin by the engineered E. coli reached 258.5 +/- 8.8 mg/L. This study lays a significant foundation for microbial production of rosin and its derivatives using glucose as the renewable carbon source.
C1 [Zhou, Wei; Bi, Huiping; Zhuang, Yibin; He, Qinglin; Yin, Hua; Liu, Tao; Ma, Yanhe] Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Tianjin 300308, Peoples R China.
   [Zhou, Wei; Bi, Huiping; Zhuang, Yibin; He, Qinglin; Yin, Hua; Liu, Tao] Chinese Acad Sci, Key Lab Syst Microbial Biotechnol, Tianjin 300308, Peoples R China.
   [Zhou, Wei] Univ Chinese Acad Sci, Beijing, Peoples R China.
C3 Chinese Academy of Sciences; Tianjin Institute of Industrial
   Biotechnology, CAS; Chinese Academy of Sciences; Chinese Academy of
   Sciences; University of Chinese Academy of Sciences, CAS
RP Liu, T (corresponding author), Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Tianjin 300308, Peoples R China.; Liu, T (corresponding author), Chinese Acad Sci, Key Lab Syst Microbial Biotechnol, Tianjin 300308, Peoples R China.
EM liu_t@tib.cas.cn
RI Zhou, Wei/GSE-0071-2022
OI Zhou, Wei/0000-0001-7540-2459
FU 973 Program of China [2012CB721100]; National Natural Science Foundation
   of China [31300040, 21302214, 31400026]; Biological Resources Service
   Plan of CAS [ZSTH-023]; Sciences and Technology Planning Projects of
   Tianjin city [13ZCZDSY05100]; Youth Innovation Promotion Association CAS
   [2017207]
FX This work was supported by grants from the 973 Program of China
   (2012CB721100), the National Natural Science Foundation of China
   (31300040, 21302214, and 31400026), the Biological Resources Service
   Plan of CAS (ZSTH-023), the Sciences and Technology Planning Projects of
   Tianjin city (13ZCZDSY05100), and the Youth Innovation Promotion
   Association CAS (2017207).
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NR 41
TC 21
Z9 28
U1 0
U2 82
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD MAR 15
PY 2017
VL 65
IS 10
BP 2129
EP 2135
DI 10.1021/acs.jafc.7b00076
PG 7
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA EO6MJ
UT WOS:000396806900014
PM 28229589
DA 2026-05-27
ER

PT J
AU Chen, N
   Wang, NN
   Du, C
   Zhang, JL
   Guo, YX
   Zhang, Y
AF Chen, Nan
   Wang, Na-Ni
   Du, Chen
   Zhang, Jia-Li
   Guo, Yi-Xun
   Zhang, Yan
TI Amelioration of Fructus Ligustri Lucidi and its phenol glycosides on
   hypercalciuria via stimulating PTH1R/PKA/TRPV5 signaling
SO PHYTOMEDICINE
LA English
DT Article
DE Calcium; Fructus Ligustri Lucidi; Kidney; Parathyroid hormone; Phenol
   glycoside; TRPV5
ID EPITHELIAL CALCIUM-CHANNEL; PARATHYROID-HORMONE; OVARIECTOMIZED MICE;
   WATER FRACTION; EXTRACT; RECEPTOR; BALANCE; TRPV5; EXPRESSION;
   PHYSIOLOGY
AB Background: Our early studies performed on aged rats, ovariectomized (OVX) rats and diabetic mice, indicated the calciotropic role of Fructus Ligustri Lucidi (FLL), the fruit of Ligustrum lucidum Ait., in mediating calcium homeostasis which was partially attributed to its stimulation on renal calcium reabsorption.
   Purpose: This study aimed to explicate the underlying molecular mechanism and explore the potential bioactive ingredients in FLL.
   Study design and methods: The OVX C57BL/6 J mice were orally administered with low (FL, 75 mg/kg), middle (FM, 225 mg/kg) or high (FH, 675 mg/kg) dose of extract of Fructus Ligustri Lucidi for 10 weeks. The biological properties of trabecular bone were measured by micro-CT and H & E staining. The molecular expression was assessed by immunoblotting and immunostaining. The potential active components were identified by cell membrane chromatography (CMC) and explored in renal tubular cells with Fluo-3/AM fluorescent staining to indicate intracellular calcium level. The male mice fed with high calcium diet (1.2% Ca) and orally treated with active components for 3 weeks.
   Results: Treatment of OVX mice with FLL extract suppressed the elevation in urinary calcium level (FH, 0.081 +/- 0.012, vs. OVX, 0.189 +/- 0.038 mg/mg), and increased bone mineral density (FH, 62.41 +/- 2.57, vs. OVX, 43.72 +/- 8.43 mg/ccm) and percentage of trabecular bone area. It also decreased circulating PTH level (FH, 66.69 +/- 10.94, vs. OVX, 303.50 +/- 26.56 pg/ml) and up-regulated TRPV5 expression in renal cortex of OVX mice as well as enhanced the expression of PTH receptor (PTH1R) and the ratio of p-PKA/PKA. The PKA inhibitor H89 abolished the induction of serum, prepared from rats treated with FLL extract, on PKA/TRPV5 signaling in renal tubular cells. The CMC identified phenol glycosides, including salidroside and oleuropein, which increased intracellular calcium content, promoted expression of PTH1R and TRPV5 and ratio of p-PKA/PKA as well as decreased calcium excretion in urine of mice fed with high calcium diet.
   Conclusion: Salidroside and oleuropein are major ingredients contributing to the anti-hypercalciuria effects of FLL via acting on PTH1R/PKA/TRPV5 signaling in kidney. Further translational research would be required.
C1 [Chen, Nan; Zhang, Jia-Li; Guo, Yi-Xun; Zhang, Yan] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Spine Dis Res Inst, Shanghai 200032, Peoples R China.
   [Chen, Nan; Zhang, Jia-Li; Guo, Yi-Xun; Zhang, Yan] Minist Educ, Key Lab Theory & Therapy Muscles & Bones, Shanghai 200032, Peoples R China.
   [Wang, Na-Ni] Zhejiang Acad Tradit Chinese Med, Dept Med, Hangzhou 310007, Peoples R China.
   [Du, Chen] Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western, Dept Gynecol, Shanghai 200437, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Tongde Hospital of
   Zhejiang Province; Shanghai University of Traditional Chinese Medicine
RP Zhang, Y (corresponding author), 725 South Wanping Rd, Shanghai 200032, Peoples R China.
EM medicineyan@aliyun.com
OI Zhang, Jiali/0000-0003-4885-5254; chen, nan/0000-0003-4353-0127
FU National Natural Science Foundation of China [82074468, 81973447];
   Program of Shanghai Academic Research Leader [19XD1423800]; Scientific
   and Innovative Action Plan from Science and Technology Commission of
   Shanghai Municipality [21400760400]; Shanghai Collaborative Innovation
   Center of Industrial Transformation of Hospital TCM Preparation
FX This study was supported in part by National Natural Science Foundation
   of China (82074468, 81973447), Program of Shanghai Academic Research
   Leader (19XD1423800), and Scientific and Innovative Action Plan from
   Science and Technology Commission of Shanghai Municipality
   (21400760400). Shanghai Collaborative Innovation Center of Industrial
   Transformation of Hospital TCM Preparation.
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NR 44
TC 5
Z9 7
U1 1
U2 24
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD APR
PY 2022
VL 98
AR 153982
DI 10.1016/j.phymed.2022.153982
PG 14
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA 7X1RF
UT WOS:000913980800001
PM 35168092
DA 2026-05-27
ER

PT J
AU Park, J
   Yasir, M
   Han, ET
   Han, JH
   Park, WS
   Choe, J
   Chun, W
AF Park, Jinyoung
   Yasir, Muhammad
   Han, Eun-Taek
   Han, Jin-Hee
   Park, Won Sun
   Choe, Jongseon
   Chun, Wanjoo
TI Exploring the Therapeutic Potential of Rehmannia glutinosa: A
   Network Pharmacology and Molecular Docking Analysis Across Multiple
   Diseases
SO CURRENT ISSUES IN MOLECULAR BIOLOGY
LA English
DT Article
DE <italic>Rehmannia glutinosa</italic> (Orobanchaceae); network
   pharmacology; molecular docking; bioactive compounds; protein-protein
   interaction; allergy; anemia; diabetes; menopause
ID GLYCATION END-PRODUCTS; OXIDATIVE STRESS; CAFFEIC ACID; EXPRESSION;
   INFLAMMATION; CYCLOOXYGENASE-2; COMPONENTS; MELATONIN; GERANIOL; URIDINE
AB Rehmannia glutinosa (RG), a fundamental herb in traditional Chinese medicine belonging to the Orobanchaceae family, has been widely used for centuries due to its diverse therapeutic properties, including promoting blood circulation, enhancing immunity, managing diabetes, reducing inflammation, and supporting kidney function. Despite its traditional significance, scientific studies on RG's therapeutic mechanisms remain limited, and its underlying pharmacological pathways are not extensively elucidated. This study employed network pharmacology and molecular docking to identify RG's active compounds and investigate their therapeutic potential in allergy, anemia, diabetes, and menopause. From an initial pool of 122 compounds, 50 bioactive compounds were screened based on bioavailability and drug-likeness, resulting in 40 active compounds and 11 target proteins closely associated with these conditions. Key active compounds identified included iridoid glycosides (rehmaglutin A, B, C, D, jioglutin A, B, C, jioglutolide) and other bioactive molecules such as caffeic acid, geraniol, 5-hydroxytryptamine, melatonin, and rhodioloside. Molecular docking technology was employed to verify the stable binding of target proteins with active compounds. Protein-protein interaction (PPI) analysis revealed that RG's core target proteins are central to pathways regulating inflammation, cell survival, apoptosis, and immune response. Enrichment analyses demonstrated that RG's target proteins intersect significantly with pathways including the AGE-RAGE signaling pathway in diabetic complications, IL-17, HIF-1 signaling, and neuroactive ligand-receptor interactions, all of which are essential in managing diabetes and menopause symptoms. These findings underscore RG's multi-target therapeutic potential, particularly in modulating immunity, metabolism, and inflammation. This study highlights RG's potential as a therapeutic agent and provides a framework for future research to further elucidate its mechanisms and support the development of targeted drugs based on RG's active compounds.
C1 [Park, Jinyoung; Yasir, Muhammad; Chun, Wanjoo] Kangwon Natl Univ, Sch Med, Dept Pharmacol, Chunchon 24341, South Korea.
   [Han, Eun-Taek; Han, Jin-Hee] Kangwon Natl Univ, Sch Med, Dept Med Environm Biol & Trop Med, Chunchon 24341, South Korea.
   [Park, Won Sun] Kangwon Natl Univ, Sch Med, Dept Physiol, Chunchon 24341, South Korea.
   [Choe, Jongseon] Kangwon Natl Univ, Sch Med, Dept Microbiol & Immunol, Chunchon 24341, South Korea.
C3 Kangwon National University; Kangwon National University; Kangwon
   National University; Kangwon National University
RP Chun, W (corresponding author), Kangwon Natl Univ, Sch Med, Dept Pharmacol, Chunchon 24341, South Korea.
EM jinyoung0326@kangwon.ac.kr; yasir.khokhar1999@gmail.com;
   ethan@kangwon.ac.kr; han.han@kangwon.ac.kr; parkws@kangwon.ac.kr;
   jchoe@kangwon.ac.kr; wchun@kangwon.ac.kr
OI Han, Jin-Hee/0000-0003-0836-6675; Chun, Wanjoo/0000-0003-1984-3545;
   Choe, Jongseon/0000-0002-0424-1667
FU Korea Basic Science Institute (National Research Facilities and
   Equipment Center) [2022R1A6C101A739, 2020R1A6C101A195]; Korea Basic
   Science Institute (National Research Facilities and Equipment Center) -
   Ministry of Education
FX This work was supported by Korea Basic Science Institute (National
   Research Facilities and Equipment Center) grants funded by the Ministry
   of Education (2022R1A6C101A739, W.C.; 2020R1A6C101A195, J.C.).
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NR 53
TC 2
Z9 3
U1 7
U2 12
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1467-3037
EI 1467-3045
J9 CURR ISSUES MOL BIOL
JI Curr. Issues Mol. Biol.
PD MAY 3
PY 2025
VL 47
IS 5
AR 329
DI 10.3390/cimb47050329
PG 16
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 3AI5L
UT WOS:001495596100001
PM 40699728
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Haas, R
   Alenciks, E
   Meddle, S
   Fraley, GS
AF Haas, R.
   Alenciks, E.
   Meddle, S.
   Fraley, G. S.
TI Expression of deep brain photoreceptors in the Pekin drake: a possible
   role in the maintenance of testicular function
SO POULTRY SCIENCE
LA English
DT Article
DE rhodopsin; melanopsin; opsin 5; vertebrate ancient opsin; gonadal
   recrudescence; luteinizing hormone
ID GONADOTROPIN-RELEASING-HORMONE; EXTRARETINAL LIGHT PERCEPTION;
   DOPAMINE-MELATONIN NEURONS; BLUE MONOCHROMATIC LIGHT; VERTEBRATE ANCIENT
   OPSIN; PINEAL-GLAND; PREMAMMILLARY NUCLEUS; MELANOPSIN EXPRESSION;
   PHOTOSEXUAL RESPONSE; TURKEY HYPOTHALAMUS
AB Several putative deep brain photoreceptors (DBPs) have been identified, such as melanopsin, opsin 5, and vertebrate ancient opsin. The aim of this study was to elucidate the role of DBPs in gonadal regulation in the Pekin drake. As previously reported, we observed opsin-like immunoreactivity (-ir) in the lateral septum (LS), melanopsin-ir in the premammillary nucleus (PMM), and opsin 5-ir in the periventricular organ. To determine the sensitivity of the DBPs to specific wavelengths of light, drakes were given an acute exposure to red, blue, or white light. Blue light stimulated an increase (P < 0.01) in the immediate early gene fra-2-ir co-expression in melanopsin-ir neurons in the PMM, and red light increased (P < 0.05) fra-2-ir co-expression in opsin-ir neurons, suggesting these neurons are blue- and red-receptive, respectively. To further investigate this photoperiodic response, we exposed drakes to chronic red, long-day white, short-day white, or blue light. Blue light elicited gonadal regression, as testes weight (P < 0.001) and plasma luteinizing hormone (LH) levels (P < 0.001) were lower compared to drakes housed under long-day white light. Photo-regressed drakes experienced complete gonadal recrudescence when housed under long-day red and blue light. qRT-PCR analyses showed that gonadally regressed drakes showed reduced levels (P < 0.01) of gonadotropin releasing hormone (GnRH) mRNA but not photoreceptor or GnIH mRNAs compared to gonadally functional drakes. Our data suggest DBP in the LS may be rhodosin and multiple DBPs are required to fully maintain gonadal function in Pekin drakes.
C1 [Haas, R.; Alenciks, E.; Fraley, G. S.] Hope Coll, Biol Dept, Holland, MI 49423 USA.
   [Meddle, S.] Univ Edinburgh, Roslin Inst, Roslin Inst Bldg,Easter Bush Campus, Roslin EH25 9RG, Midlothian, Scotland.
   [Meddle, S.] Univ Edinburgh, Royal Dick Sch Vet Studies, Roslin Inst Bldg,Easter Bush Campus, Roslin EH25 9RG, Midlothian, Scotland.
C3 Hope College; University of Edinburgh; UK Research & Innovation (UKRI);
   Biotechnology and Biological Sciences Research Council (BBSRC); Roslin
   Institute; UK Research & Innovation (UKRI); Biotechnology and Biological
   Sciences Research Council (BBSRC); Roslin Institute; University of
   Edinburgh
RP Fraley, GS (corresponding author), Hope Coll, Biol Dept, Holland, MI 49423 USA.
EM fraley@hope.edu
RI ; Meddle, Simone/C-7748-2013
OI Fraley, Gregory S/0000-0002-5488-1320; 
FU Maple Leaf Farms, Inc.; National Science Foundation REU [0754293];
   Department of Biology at Hope College; Roslin Institute from
   Biotechnology and Biological Sciences Research Council [BB/J004316/1,
   BB/J004332/1]; BBSRC [BBS/E/D/30002276, BBS/E/D/20221655,
   BBS/E/D/20251969] Funding Source: UKRI; Biotechnology and Biological
   Sciences Research Council [BBS/E/D/30002276, BBS/E/D/20251969,
   BBS/E/D/20221655] Funding Source: researchfish; Direct For Biological
   Sciences; Div Of Biological Infrastructure [0754293] Funding Source:
   National Science Foundation
FX The authors wish to thank Maple Leaf Farms, Inc. for their support for
   this research project. This work was funded in part by the National
   Science Foundation REU award 0754293 to GSF. We also wish to thank the
   Department of Biology at Hope College for their continued support of our
   research. SLM acknowledges Roslin Institute strategic grant funding from
   the Biotechnology and Biological Sciences Research Council (BB/J004316/1
   and BB/J004332/1). We also thank Dr. S.M. Fraley and Dr. Wayne J.
   Kuenzel for their critical comments on this manuscript.
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NR 68
TC 23
Z9 27
U1 0
U2 13
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0032-5791
EI 1525-3171
J9 POULTRY SCI
JI Poult. Sci.
PD AUG
PY 2017
VL 96
IS 8
BP 2908
EP 2919
DI 10.3382/ps/pex037
PG 12
WC Agriculture, Dairy & Animal Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture
GA FC3UI
UT WOS:000406764500047
PM 28339754
OA Green Submitted, Green Published, hybrid
DA 2026-05-27
ER

PT J
AU Li, ZH
   Xiao, R
   Pan, CD
   Jiang, DA
   Wang, Q
AF Li, Zhao-Hui
   Xiao, Ruan
   Pan, Cun-De
   Jiang, De-An
   Wang, Qiang
TI Morphological characteristics, Distribution Morphological Secondary
   Metabolites and Biological Activity of Rhodiolu L.
SO MINI-REVIEWS IN ORGANIC CHEMISTRY
LA English
DT Review
DE Bioactivity; distribution; morphological characteristics; Rhodiola L;
   salidroside; secondary metabolites
ID STANDARDIZED EXTRACT SHR-5; CHINESE NATURAL MEDICINES; ROSEA L.;
   DOUBLE-BLIND; BIOACTIVE CONSTITUENTS; CHEMICAL-COMPOSITION; OXIDATIVE
   STRESS; IMBRICATA EDGEW; AQUEOUS EXTRACT; ESSENTIAL OIL
AB Members of the genus Rhodiola L. are perennial herbaceous plants indigenous to high altitudes in the Arctic, throughout the central Himalayan Mountain regions, Qinghai-Tibetan Plateau and to the European Alps. Nearly, 84 Rhodiola species (including subspecies and varieties) are recorded worldwide. For thousands of years, Rhodiola species has been in use as an important adaptogen, hemostatic, and tonic in traditional Tibetan medicines (TTM). The review describes the morphological characteristics of Rhodiola species, provides information about their distribution, summarizes the secondary metabolites of R. rosea that is the predominant species screened in efficacy studies, and compares the differences of secondary metabolites among other species such as R. crenulata, R. sachlinesis and R. sacra. Rhodiola L containing numerous active chemical compounds: phenyl propanoids, phenylethanol derivatives, flavanoids, terpenes, and phenolic acids. These compounds have important biological activities, such as adaptogenic/adaptogen, antioxidant, antifatigue, anticancer, postponing ageing, immunomodulatory, cardioprotective, metabolic effects, and antineuronal apoptosis effects.
C1 [Li, Zhao-Hui; Xiao, Ruan; Wang, Qiang] Zhejiang Univ, Ningbo Inst Technol, Ningbo 315100, Zhejiang, Peoples R China.
   [Li, Zhao-Hui] Zhejiang Pharmaceut Coll, Dept Tradit Chinese Med, Ningbo, Zhejiang, Peoples R China.
   [Pan, Cun-De] Xinjiang Agr Univ, Coll Forest, Urumqi, Peoples R China.
   [Jiang, De-An] Zhejiang Univ, Coll Life Sci, Hangzhou, Zhejiang, Peoples R China.
C3 Zhejiang University; Xinjiang Agricultural University; Zhejiang
   University
RP Wang, Q (corresponding author), Zhejiang Univ, Ningbo Inst Technol, Ningbo 315100, Zhejiang, Peoples R China.
EM wangqiangsky@263.net
FU Natural Science Foundation of China (NSFC) [30470330, 30360087,
   30770334, 30960313]
FX The authors declare no conflict of interest. The authors are grateful to
   the Natural Science Foundation of China (NSFC, Project No: 30470330,
   30360087, 30770334,30960313) for the financial support of the work.
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NR 95
TC 2
Z9 2
U1 2
U2 66
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1570-193X
EI 1875-6298
J9 MINI-REV ORG CHEM
JI Mini-Rev. Org. Chem.
PY 2016
VL 13
IS 5
BP 389
EP 401
DI 10.2174/1570193X13666161017142011
PG 13
WC Chemistry, Organic
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA EO2HM
UT WOS:000396517200006
DA 2026-05-27
ER

PT J
AU Li, MQ
   Xu, T
   Zhou, F
   Wang, MM
   Song, HX
   Xiao, X
   Lu, BY
AF Li, Maiquan
   Xu, Tao
   Zhou, Fei
   Wang, Mengmeng
   Song, Huaxin
   Xiao, Xing
   Lu, Baiyi
TI Neuroprotective Effects of Four Phenylethanoid Glycosides on
   H2O2-Induced Apoptosis on PC12 Cells via the
   Nrf2/ARE Pathway
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE Keap1; Nrf2; Neuroprotective; PC12 cells; PhGs
ID TRAUMATIC BRAIN-INJURY; OXIDATIVE STRESS; MOUSE MODEL; ANTIOXIDANT;
   PROTECTS; DISEASE; SYSTEM; VITRO
AB Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key transcription factor against oxidative stress and neurodegenerative disorders. Phenylethanoid glycosides (PhGs; salidroside, acteoside, isoacteoside, and echinacoside) exhibit antioxidant and neuroprotective bioactivities. This study was performed to investigate the neuroprotective effect and molecular mechanism of PhGs. PhGs pretreatment significantly suppressed H2O2-induced cytotoxicity in PC12 cells by triggering the nuclear translocation of Nrf2 and reversing the downregulated protein expression of heme oxygenase 1 (HO-1), NAD(P)H quinone oxidoreductase 1 (NQO1), glutamate cysteine ligase-catalytic subunit (GCLC), and glutamate-cysteine ligase modifier subunit (GCLM). Nrf2 siRNA or HO-1 inhibitor zinc protoporphyrin (ZnPP) reduced the neuroprotective effect. PhGs showed potential interaction with the Nrf2 binding site in Kelch-like ECH-association protein 1 (Keap1). This result may support the hypothesis that PhGs are activators of Nrf2. We demonstrated the potential binding between PhGs and the Keap1-activated Nrf2/ARE pathway, and that PhGs with more glycosides had enhanced effects.
C1 [Li, Maiquan; Xu, Tao; Zhou, Fei; Wang, Mengmeng; Song, Huaxin; Lu, Baiyi] Zhejiang Univ, Zhejiang Key Lab Agrofood Proc,Minist Agr & Rural, Natl Engn Lab Intelligent Food Technol & Equipmen, Key Lab Agroprod Nutr Evaluat,Key Lab Agroprod Po, Hangzhou 310058, Zhejiang, Peoples R China.
   [Xiao, Xing] Guangzhou Univ Chinese Med, Coll Clin Med 1, Guangzhou 510006, Guangdong, Peoples R China.
C3 Zhejiang University; Guangzhou University of Chinese Medicine
RP Lu, BY (corresponding author), Zhejiang Univ, Zhejiang Key Lab Agrofood Proc,Minist Agr & Rural, Natl Engn Lab Intelligent Food Technol & Equipmen, Key Lab Agroprod Nutr Evaluat,Key Lab Agroprod Po, Hangzhou 310058, Zhejiang, Peoples R China.
EM 11413040@zju.edu.cn; txu@zju.edu.cn; feizhou@zju.edu.cn;
   11613027@zju.edu.cn; 21713034@zju.edu.cn; fushengmengxx@gmail.com;
   bylu@zju.edu.cn
RI ; Xiao, Xinghuo/LCD-9599-2024; Yang, Bowen/KWV-0501-2024
OI Wang, Mengmeng/0000-0003-0856-4831; Xu, Tao/0000-0002-7683-7785; 
FU National Major R & D Program of China [2017YFD0400200]; Zhejiang
   Provincial Natural Science Foundation of China [R15C200002]; Special
   Project of Agricultural Product Quality Safety Risk Assessment, Ministry
   of Agriculture and Rural affairs of China [GJFP2018015]
FX This study was supported by the National Major R & D Program of China
   (No. 2017YFD0400200), the Zhejiang Provincial Natural Science Foundation
   of China (No. R15C200002) and the Special Project of Agricultural
   Product Quality Safety Risk Assessment (No. GJFP2018015), Ministry of
   Agriculture and Rural affairs of China.
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NR 39
TC 69
Z9 75
U1 1
U2 54
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR
PY 2018
VL 19
IS 4
AR 1135
DI 10.3390/ijms19041135
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA GJ0XU
UT WOS:000434978700214
PM 29642608
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Sist, P
   Tramer, F
   Lorenzon, P
   Urbani, R
   Vrhovsek, U
   Bernareggi, A
   Sciancalepore, M
AF Sist, Paola
   Tramer, Federica
   Lorenzon, Paola
   Urbani, Ranieri
   Vrhovsek, Urska
   Bernareggi, Annalisa
   Sciancalepore, Marina
TI Rhodiola rosea, a protective antioxidant for intense physical
   exercise: An in vitro study
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Rhodiola rosea; Mouse myotubes; Skeletal muscle; Physical exercise;
   Reactive oxygen species
ID SKELETAL-MUSCLE CELLS; INDUCED OXIDATIVE STRESS; REACTIVE OXYGEN;
   VERSATILE ADAPTOGEN; PHENOLIC-COMPOUNDS; EXTRACTS; SUPPLEMENTATION;
   ROOTS; SALIDROSIDE; PERFORMANCE
AB In physiological conditions, the response to oxidative stress induced by strenuous physical training, is not always efficient. Furthermore, a weak muscle fiber antioxidant system can contribute to muscle wasting during ageing and pathological conditions. Natural antioxidant supplements could counteract the effects of oxidative stress. An in vitro model of exercise allowed us to mimic intense or moderate exercise by electrically stimulating cultured mouse myotubes with high- and/or low-frequency pulses; the resulting ROS production was then monitored. The herbal supplement Rhodiola rosea aqueous extract was characterized in terms of its polyphenol content and used to test for antioxidant activity against ROS, produced during muscle contraction. Our results showed that Rhodiola rosea extract reduced the oxidative stress produced by muscle contraction and brought values of ROS production back to physiological levels. We suggest that Rhodiola rosea root extract could exert a protective antioxidant role during intense physical exercise.
C1 [Sist, Paola; Urbani, Ranieri] Univ Trieste, Dept Chem & Pharmaceut Sci, Via L Giorgieri 1, I-34127 Trieste, Italy.
   [Tramer, Federica; Lorenzon, Paola; Bernareggi, Annalisa; Sciancalepore, Marina] Univ Trieste, Dept Life Sci, Via A Fleming 22, I-34127 Trieste, Italy.
   [Tramer, Federica; Lorenzon, Paola; Bernareggi, Annalisa; Sciancalepore, Marina] Univ Trieste, Ctr Neurosci BRAIN, Via A Fleming 22, I-34127 Trieste, Italy.
   [Vrhovsek, Urska] FEM, Res & Innovat Ctr, Dept Food Qual & Nutr, Via E Mach 1, I-38010 San Michele All Adige, Italy.
C3 University of Trieste; University of Trieste; University of Trieste;
   Fondazione Edmund Mach
RP Sciancalepore, M (corresponding author), Univ Trieste, Dept Life Sci, Via A Fleming 22, I-34127 Trieste, Italy.; Sciancalepore, M (corresponding author), Univ Trieste, Ctr Neurosci BRAIN, Via A Fleming 22, I-34127 Trieste, Italy.
EM psist@units.it; ftramer@units.it; plorenzon@units.it; urbani@units.it;
   urska.vrhovsek@fmach.it; abernareggi@units.it; msciancalepore@units.it
RI ; Bernareggi, Annalisa/AET-2182-2022; Vrhovsek, Urska/E-9950-2011
OI Urbani, Ranieri/0000-0002-7802-3697; Bernareggi,
   Annalisa/0000-0002-7007-8466; LORENZON, Paola/0000-0002-9526-6471;
   SCIANCALEPORE, MARINA/0000-0002-6872-9477; 
FU grants FRA2013 (University of Trieste, Italy); Fondazione Beneficentia
   Stiftung (Liechtenstein)
FX The authors are grateful to Dr. Andrew Constanti (UCL School of
   Pharmacy, London, UK) for critically reading the manuscript and to Gaia
   Ziraldo for preparing the cell cultures. This work was supported by
   grants FRA2013 (University of Trieste, Italy) and Fondazione
   Beneficentia Stiftung (Liechtenstein).
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NR 84
TC 10
Z9 14
U1 1
U2 42
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1756-4646
J9 J FUNCT FOODS
JI J. Funct. Food.
PD SEP
PY 2018
VL 48
BP 27
EP 36
DI 10.1016/j.jff.2018.06.022
PG 10
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA GX2TS
UT WOS:000447573600004
OA Green Submitted
DA 2026-05-27
ER

PT J
AU Long, ZM
   Bi, KS
   Huo, YS
   Yan, XY
   Zhao, X
   Chen, XH
AF Long, Zhi-Min
   Bi, Kai-Shun
   Huo, Yan-Shuang
   Yan, Xiao-Yu
   Zhao, Xu
   Chen, Xiao-Hui
TI Simultaneous quantification of three iridoids in rat plasma after oral
   administration of Zhi-zi-chi decoction using LC-MS
SO JOURNAL OF SEPARATION SCIENCE
LA English
DT Article
DE 6 alpha-Hydroxygeniposide; Geniposide; Genipin gentiobioside;
   Pharmacokinetics study; Zhi-zi-chi decoction
ID GARDENIA-JASMINOIDES; MASS-SPECTROMETRY; PAEONIFLORIN; GENIPOSIDE;
   EXTRACT; GENIPIN; MICE
AB A sensitive and efficient liquid chromatography-mass spectrometry (LC-MS) method was developed and validated for the simultaneous determination of geniposide, 6 alpha-hydroxygeniposide, and genipin gentiobioside in rat plasma. After the addition of internal standard (I. S.) salidroside and acidification (formic acid, 0.1%), plasma samples were carried out by protein precipitation with acetonitrile and separated on a Kromasil C(18) column (200 mm x 4.6 mm, 5 mu m) within a runtime of 15.0 min. The linear ranges were 2-250 ng/mL for both 6 alpha-hydroxygeniposide and genipin gentiobioside and 2-2000 ng/mL for geniposide, respectively. The lower limit of quantification (LLOQ) was 2 ng/mL for all the analytes. The validated method was successfully applied to the pharmacokinetics study of geniposide, 6 alpha-hydroxygeniposide, and genipin gentiobioside in rats after oral administration of Zhi-zi-chi decoction.
C1 [Long, Zhi-Min; Bi, Kai-Shun; Huo, Yan-Shuang; Yan, Xiao-Yu; Zhao, Xu; Chen, Xiao-Hui] Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China.
C3 Shenyang Pharmaceutical University
RP Chen, XH (corresponding author), Shenyang Pharmaceut Univ, Sch Pharm, Wenhua Rd 103, Shenyang 110016, Peoples R China.
EM cxh_syphu@yahoo.com.cn
CR [Anonymous], 2014, Guidance for industry: bioanalytical method validation FDA (draft guidance)
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NR 17
TC 14
Z9 19
U1 0
U2 29
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1615-9306
J9 J SEP SCI
JI J. Sep. Sci.
PD OCT
PY 2011
VL 34
IS 20
SI SI
BP 2854
EP 2860
DI 10.1002/jssc.201100387
PG 7
WC Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA 846LY
UT WOS:000296905400009
PM 21796788
DA 2026-05-27
ER

PT J
AU Xu, WQ
   Yang, TC
   Zhang, JY
   Li, HG
   Guo, M
AF Xu, Wenqian
   Yang, Tianchuang
   Zhang, Jinyuan
   Li, Heguo
   Guo, Min
TI Rhodiola rosea: a review in the context of PPPM approach
SO EPMA JOURNAL
LA English
DT Review
DE Rhodiola rosea; Adaptogens; Neocoronitis; Non-communicable illnesses;
   Suboptimal health; Predictive preventive personalised medicine (PPPM /
   3PM)
ID TRADITIONAL CHINESE MEDICINE; DRUG-DELIVERY SYSTEMS; INDUCED LUNG
   INJURY; MOLECULAR-MECHANISMS; ADIPOSE-TISSUE; CANCER CELLS; SALIDROSIDE;
   STRESS; PROLIFERATION; INHIBITION
AB A natural "medicine and food" plant, Rhodiola rosea (RR) is primarily made up of organic acids, phenolic compounds, sterols, glycosides, vitamins, lipids, proteins, amino acids, trace elements, and other physiologically active substances. In vitro, non-clinical and clinical studies confirmed that it exerts anti-inflammatory, antioxidant, and immune regulatory effects, balances the gut microbiota, and alleviates vascular circulatory disorders. RR can prolong life and has great application potential in preventing and treating suboptimal health, non-communicable diseases, and COVID-19. This narrative review discusses the effects of RR in preventing organ damage (such as the liver, lung, heart, brain, kidneys, intestines, and blood vessels) in non-communicable diseases from the perspective of predictive, preventive, and personalised medicine (PPPM/3PM). In conclusion, as an adaptogen, RR can provide personalised health strategies to improve the quality of life and overall health status.
C1 [Xu, Wenqian] Henan Univ Tradit Chinese Med, Zhengzhou, Henan, Peoples R China.
   [Yang, Tianchuang] Zhongshan Huangpu Peoples Hosp, Zhongshan, Peoples R China.
   [Zhang, Jinyuan] Third Peoples Hosp Henan Prov, Zhengzhou, Peoples R China.
   [Li, Heguo; Guo, Min] Henan Univ Tradit Chinese Med, Dept Spleen Stomach Liver & Gallbladder, Affiliated Hosp 1, Zhengzhou, Peoples R China.
C3 Henan University of Traditional Chinese Medicine; Henan University of
   Traditional Chinese Medicine
RP Guo, M (corresponding author), Henan Univ Tradit Chinese Med, Dept Spleen Stomach Liver & Gallbladder, Affiliated Hosp 1, Zhengzhou, Peoples R China.
EM lhg1964@163.com; hbguomin@sina.com
RI xu, wenqian/KPB-0028-2024
OI xu, wenqian/0000-0003-2815-1276
FU Henan Province key specialty for the treatment of major diseases
FX No Statement Available
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NR 230
TC 12
Z9 13
U1 8
U2 30
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 1878-5077
EI 1878-5085
J9 EPMA J
JI EPMA J.
PD JUN
PY 2024
VL 15
IS 2
BP 233
EP 259
DI 10.1007/s13167-024-00367-3
EA MAY 2024
PG 27
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA SX9R9
UT WOS:001232221600001
PM 38841616
OA Green Submitted, Bronze
DA 2026-05-27
ER

PT J
AU Liu, K
   Ren, XM
   You, QS
   Gu, MM
   Wang, F
   Wang, S
   Ma, CH
   Li, WN
   Ye, Q
AF Liu, Kun
   Ren, Xiu-mei
   You, Qing-sheng
   Gu, Ming-Ming
   Wang, Fei
   Wang, Shuo
   Ma, Chun-Hui
   Li, Wei-Nan
   Ye, Qing
TI Ameliorative Effect of Dangguibuxue Decoction against
   Cyclophosphamide-Induced Heart Injury in Mice
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID ACUTE LUNG INJURY; INDUCED MYOCARDIAL-INFARCTION; TANSHINONE IIA
   SULFONATE; KAPPA-B PATHWAY; IN-VITRO; RATS; SALIDROSIDE; VIVO;
   INFLAMMATION; ARTHRITIS
AB Dangguibuxue decoction (DBD), a kind of Chinese herbal medicine, has been widely used to treat blood deficiency disease in China. In this experiment, we studied the effects of the Dangguibuxue decoction (DBD) on the myocardial injury induced by cyclophosphamide in mice. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatine kinase (CK), and lactic dehydrogenase (LDH) in serum were detected by commercial kits. Total white blood cell (WBCs), platelets, and cytokines pathological changes of heart tissue were also examined. In addition, the protein levels of the NF-kappa B pathway were detected to reveal its mechanism. The results showed that DBD significantly decreased the levels of ALT, AST, CK, and LDH and increased WBCs in CTX-induced mice. In addition, DBD significantly alleviated pathological changes of heart tissue. DBD significantly reduced the protein expressions of NF-kappa B signaling pathway. In summary, DBD can be considered an effective drug to alleviate CTX-induced heart damage in mice.
C1 [Liu, Kun; You, Qing-sheng; Gu, Ming-Ming; Wang, Fei; Wang, Shuo; Ma, Chun-Hui; Li, Wei-Nan] Nantong Univ, Affiliated Hosp, Dept Cardiothorac Surg, Nantong, Peoples R China.
   [Ren, Xiu-mei] Nantong Univ, Affiliated Hosp, Dept Tradit Chinese Med, Nantong, Peoples R China.
   [Ye, Qing] Nantong Univ, Affiliated Hosp, Dept Obstet & Gynecol, Nantong, Peoples R China.
C3 Nantong University; Nantong University; Nantong University
RP Ye, Q (corresponding author), Nantong Univ, Affiliated Hosp, Dept Obstet & Gynecol, Nantong, Peoples R China.
EM jsntyeqing001@sina.com
RI ma, chunhui/KJM-2967-2024
FU Six Talent Peaks Project in Jiangsu Province, China [2014-YY-006]; China
   Postdoctoral Science Foundation of China [2013M541705]; Postdoctoral
   Research Foundation of Jiangsu Province, China [1301072C]; Science
   Foundation of Nantong City, Jiangsu Province, China [MS32015016];
   Natural Science Foundation of Jiangsu Province, China [BK20171257]; "333
   Project" of Jiangsu Province, China [BRA2017557]
FX The present study was supported by grants from the Six Talent Peaks
   Project in Jiangsu Province, China (Grant no. 2014-YY-006), the China
   Postdoctoral Science Foundation of China (Grant no. 2013M541705), the
   Postdoctoral Research Foundation of Jiangsu Province, China (Grant no.
   1301072C), the Science Foundation of Nantong City, Jiangsu Province,
   China (Grant no. MS32015016), the Natural Science Foundation of Jiangsu
   Province, China (Grant no. BK20171257), and the "333 Project" of Jiangsu
   Province, China (Grant no. BRA2017557).
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NR 34
TC 18
Z9 19
U1 0
U2 7
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PY 2018
VL 2018
AR 8503109
DI 10.1155/2018/8503109
PG 10
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA GZ8YD
UT WOS:000449781100001
PM 30515415
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Si, YC
   Li, Q
   Xie, CE
   Niu, X
   Xia, XH
   Yu, CY
AF Si, Yin-chu
   Li, Qiang
   Xie, Chun-e
   Niu, Xin
   Xia, Xiao-hui
   Yu, Chang-yuan
TI Chinese herbs and their active ingredients for activating xue
   (blood) promote the proliferation and differentiation of neural stem
   cells and mesenchymal stem cells
SO CHINESE MEDICINE
LA English
DT Review
ID GENERATION; MIGRATION; THERAPY; NEURONS
AB Some Chinese herbs are anti-thrombolysis, and anti-inflammatory, improves brain RNA content, promotes brain protein synthesis, enhances dopamine function, regulates brain hormones, and improves microcirculation in central nervous system that might improve, repair and rehabilitation from the stroke and brain injury. Specific Chinese herbs and their components, such as Acanthopanax, Angelica, could maintain the survival of neural stem cells, and Rhodiola, Ganoderma spore Polygala, Tetramethylpyrazine, Gardenia, Astragaloside and Ginsenoside Rg1 promoted proliferation of neural stem cells, and Rhodiola, Astragaloside promoted differentiation of neural stem cell into neuron and glia in vivo. Astragalus, Safflower, Musk, Baicalin, Geniposide, Ginkgolide B, Cili polysaccharide, Salidroside, Astragaloside, Antler polypeptides, Ginsenoside Rg1, Panax notoginseng saponins promoted proliferation and differentiation of neural stem cells in vitro. Salvia, Astragalus, Ginsenoside Rg1, P. notoginseng saponins, Musk polypeptide, Muscone and Ginkgolide B promoted neural-directed differentiation of MSCs into nerve cells. These findings are encouraging further research into the Chinese herbs for developing drugs in treating patients of stroke and brain injury.
C1 [Si, Yin-chu] Beijing Univ Chinese Med, Dept Anat, Beijing 100029, Peoples R China.
   [Li, Qiang] Beijing Univ Chinese Med, Sch Chinese Mat Med, Dept Phytochem, Beijing 100029, Peoples R China.
   [Xie, Chun-e] Dongfang Hosp, Dept Gastroenterol, Beijing, Peoples R China.
   [Niu, Xin] Beijing Univ Chinese Med, Dept Physiol, Beijing, Peoples R China.
   [Xia, Xiao-hui] Inst China Resources Double Crane Pharmaceut Co L, Beijing, Peoples R China.
   [Yu, Chang-yuan] Beijing Univ Chem & Technol, Coll Life Sci & Technol, Beijing 100029, Cleveland, Peoples R China.
C3 Beijing University of Chinese Medicine; Beijing University of Chinese
   Medicine; China Resources Group; Beijing University of Chemical
   Technology
RP Si, YC (corresponding author), Beijing Univ Chinese Med, Dept Anat, Beijing 100029, Peoples R China.
EM siyc@bucm.edu.cn
FU National Key Basic Research and Development Program (973 Program)
   [2011CB505404]; National Natural Science Foundation of China [81373830,
   81273631]; Innovation team project of Beijing University of Chinese
   Medicine [2011-CXTD-05, 2011-CXTD-15]
FX This paper was sponsored by the National Key Basic Research and
   Development Program (973 Program) (NO.2011CB505404), the National
   Natural Science Foundation of China (81373830, 81273631) and the
   Innovation team project of Beijing University of Chinese Medicine
   (NO.2011-CXTD-05, 2011-CXTD-15).
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NR 65
TC 50
Z9 64
U1 3
U2 116
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-8546
J9 CHIN MED-UK
JI Chin. Med.
PD APR 9
PY 2014
VL 9
DI 10.1186/1749-8546-9-13
PG 8
WC Integrative & Complementary Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; Pharmacology & Pharmacy
GA AF0DK
UT WOS:000334381700001
PM 24716802
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Chen, F
   Chai, YH
   Zhang, F
   Liu, YQ
   Zhang, Y
   Shi, YJ
   Zhang, JM
   Leng, YF
AF Chen, Feng
   Chai, Yi-hong
   Zhang, Fa
   Liu, Yong-qiang
   Zhang, Yan
   Shi, Ya-jing
   Zhang, Jian-ming
   Leng, Yu-fang
TI Network pharmacology analysis combined with experimental validation to
   explore the therapeutic mechanism of salidroside on intestine ischemia
   reperfusion
SO BIOSCIENCE REPORTS
LA English
DT Article
ID ISCHEMIA/REPERFUSION INJURY; PHOSPHORYLATION; INFLAMMATION; DYSFUNCTION
AB Ethnopharmacological relevance: Salidroside (SAL), a phenolic natural product present in Rhodiola rosea, are commonly used in the treatment of various ischemic-hypoxic diseases, including intestinal ischemia-reperfusion (IR) injury. However, their efficacy and potential mechanisms in the treatment of intestinal IR injury have not been investigated. Objective: The objective of the present study is to investigate the pharmacological mecha-nism of action of SAL on intestinal IR injury using a network pharmacology approach com-bined with experimental validation. Methods: In the present study, we used the Traditional Chinese Medicine Systematic Pharmacology (TCMSP) database and analysis platform and Comparative Toxicogenomics Database (CTD) to predict possible target genes of SAL, collected relevant target genes of intestinal IR injury from GeneCards and DisGenet websites, and collected summary data to screen common target genes. Then, the protein-protein interaction (PPI) target network was constructed and analyzed by STRING database and Cytoscape 3.8.2 with the above inter-secting genes. Then, gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed and the component-target-pathway network was constructed, followed by the use of molecular docking and molecular dynamic sim-ulation to verify the possible binding conformation between SAL and candidate targets to further explore the potential targets of SAL in the treatment of intestinal IR injury. Finally, an in vivo model of mouse superior mesenteric artery ligation was established to assess the anti-intestinal IR injury effect of SAL by assessing histopathological changes in mouse small intestine by HE staining, detecting inflammatory factor expression by ELISA kit, and detecting the expression of key protein targets by Western blotting. Results: A total of 166 SAL target genes and 1740 disease-related targets were retrieved, and 88 overlapping proteins were obtained as potential therapeutic targets. The pathway enrich-ment analysis revealed that the pharmacological effects of SAL on intestinal IR injury were anti-hypoxic, anti-inflammatory and metabolic pathway related, and the molecular dock -ing and molecular dynamic simulation results showed that the core bioactive components had good binding affinity for TXNIP and AMPK, and the immunoblotting results indicated that the expression levels of TXNIP and AMPK in the small intestinal tissues of mice in the drug-treated group compared with the model group were significantly changed. Conclusion: SAL may target AMPK and TXNIP domains to act as a therapeutic agent for intestinal IR. These findings comprehensively reveal the potential therapeutic targets for by Analytics August SAL against intestinal IR and provide theoretical basis for the clinical application of SAL in the treatment of intestinal IR.
C1 [Chen, Feng; Chai, Yi-hong; Liu, Yong-qiang; Zhang, Yan; Shi, Ya-jing; Zhang, Jian-ming; Leng, Yu-fang] Lanzhou Univ, Clin Med Coll 1, Lanzhou 730000, Gansu, Peoples R China.
   [Chen, Feng; Liu, Yong-qiang; Zhang, Yan; Leng, Yu-fang] First Hosp Lanzhou Univ, Dept Anesthesiol, Lanzhou 730000, Gansu, Peoples R China.
   [Zhang, Fa] Gansu Prov Hosp, Dept Urol, Lanzhou, Gansu, Peoples R China.
C3 Lanzhou University
RP Leng, YF (corresponding author), Lanzhou Univ, Clin Med Coll 1, Lanzhou 730000, Gansu, Peoples R China.; Leng, YF (corresponding author), First Hosp Lanzhou Univ, Dept Anesthesiol, Lanzhou 730000, Gansu, Peoples R China.
EM lengyf@lzu.edu.cn
RI SHI, Yajing/AAR-2964-2020; /AAL-2786-2021; chen, feng/PDX-5000-2025
OI zhang, yan/0000-0002-9625-2581; 
FU National Natural Science Foundation of China [82260381, 22JR11RA032];
   Natural Science Foundation of Gansu Province [23JRRA0951]; Gansu
   Provincial Youth Science Foundation [lzuyxcx-2022-108]; Medical
   Innovation and Development Project of Lanzhou University; First Hospital
   of Lanzhou University Youth Fund;  [81960345];  [ldyyyn2022-45]
FX This work was supported by the National Natural Science Foundation of
   China [81960345 and 82260381] , Natural Science Foundation of Gansu
   Province [22JR11RA032] ,Gansu Provincial Youth Science Foundation
   [23JRRA0951] , The First Hospital of Lanzhou University Youth Fund
   [ldyyyn2022-45] and Medical Innovation and Development Project of
   Lanzhou University [lzuyxcx-2022-108] .
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NR 59
TC 8
Z9 10
U1 0
U2 6
PU PORTLAND PRESS LTD
PI LONDON
PA 1ST FLR, 10 QUEEN STREET PLACE, LONDON, ENGLAND
SN 0144-8463
EI 1573-4935
J9 BIOSCIENCE REP
JI Biosci. Rep.
PD AUG
PY 2023
VL 43
IS 8
AR BSR20230539
DI 10.1042/BSR20230539
PG 16
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA Q2CT1
UT WOS:001055655300001
PM 37530723
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Wang, JA
   Jian, AQ
   Cui, MX
   Piao, CX
   Wang, J
   Mu, BD
   Li, GH
   Li, HM
AF Wang, Jianan
   Jian, Aqing
   Cui, Mingxun
   Piao, Chunxiang
   Wang, Juan
   Mu, Baide
   Li, Guanhao
   Li, Hongmei
TI Exploring the potential mechanisms of Acer tegmentosum Maxim in
   preventing alcoholic liver disease based on network pharmacology and
   molecular docking
SO NATURAL PRODUCT RESEARCH
LA English
DT Article
DE <italic>Acer tegmentosum</italic> Maxim; alcoholic liver disease;
   molecular docking; network pharmacology; mechanism
AB To investigate the potential mechanisms of Acer tegmentosum Maxim (AT) in preventing Alcoholic liver disease (ALD), this study used network pharmacology and molecular docking methods to screen the main active ingredients of AT for preventing core target proteins related to ALD, conducted GO and KEGG pathway enrichment analysis and performed molecular docking and visualisation. The results showed that AT's top five active components were kaempferol-3-rhamnoside, salidroside, linoleic acid, ethyl linoleate, and tyrosol. The top five core target proteins for preventing ALD with AT were SRC, AKT1, STAT3, MAPK1, and ESR1. Gene enrichment analysis indicated that AT may inhibit the occurrence of ALD by improving inflammation and cancer pathways, and the core components of AT were well combined with critical targets, further elucidated the preventive mechanism of ALD through multiple components, targets, and pathways. It can provide a new idea for studying the mechanism of AT active ingredients to prevent ALD.
C1 [Wang, Jianan; Jian, Aqing; Cui, Mingxun; Piao, Chunxiang; Wang, Juan; Mu, Baide; Li, Guanhao; Li, Hongmei] Yanbian Univ, Coll Agr, Yanji, Jilin, Peoples R China.
   [Wang, Jianan; Jian, Aqing; Cui, Mingxun; Piao, Chunxiang; Wang, Juan; Mu, Baide; Li, Guanhao; Li, Hongmei] Yanbian Univ, Food Res Ctr, Yanji, Jilin, Peoples R China.
C3 Yanbian University; Yanbian University
RP Li, GH; Li, HM (corresponding author), Yanbian Univ, Coll Agr, Yanji, Jilin, Peoples R China.; Li, GH; Li, HM (corresponding author), Yanbian Univ, Food Res Ctr, Yanji, Jilin, Peoples R China.
EM ghli@ybu.edu.cn; hmli2018@ybu.edu.cn
OI Wang, Juan/0000-0002-4160-6151
FU Yanbian University Doctoral Research Start-up Fund Project; Natural
   Science Foundation Project of Jilin Province [20200201152JC]; Yanbian
   University School-Enterprise Cooperation Project [[2021]18]
FX This work was supported by Yanbian University Doctoral Research Start-up
   Fund Project, Natural Science Foundation Project of Jilin Province
   (20200201152JC) and Yanbian University School-Enterprise Cooperation
   Project ([2021]18)
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NR 13
TC 9
Z9 12
U1 1
U2 16
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1478-6419
EI 1478-6427
J9 NAT PROD RES
JI Nat. Prod. Res.
PD MAR 19
PY 2026
VL 40
IS 6
BP 1565
EP 1569
DI 10.1080/14786419.2024.2436115
EA NOV 2024
PG 5
WC Chemistry, Applied; Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Pharmacology & Pharmacy
GA FA7IZ
UT WOS:001370315500001
PM 39628131
OA Green Submitted
DA 2026-05-27
ER

PT J
AU Gomez-Verjan, JC
   Zepeda-Arzate, EA
   Santiago-de-la-Cruz, JA
   Estrella-Parra, EA
   Rivero-Segura, NA
AF Gomez-Verjan, Juan Carlos
   Zepeda-Arzate, Emmanuel Alejandro
   Santiago-de-la-Cruz, Jose Alberto
   Estrella-Parra, Edgar Antonio
   Rivero-Segura, Nadia Alejandra
TI Unraveling the Neuroprotective Effect of Natural Bioactive Compounds
   Involved in the Modulation of Ischemic Stroke by Network Pharmacology
SO PHARMACEUTICALS
LA English
DT Article
DE natural bioactive compounds; natural products; network pharmacology;
   neuroprotection; ischemic stroke; flavonoids; terpenoids
ID MANAGEMENT; MECHANISM; BURDEN; IMPACT; AGENT; CELLS
AB Ischemic stroke (IS) is one of the leading causes of mortality worldwide. It is characterized by the partial or total occlusion of arteries that supply blood to the brain, leading to the death of brain cells. In recent years, natural bioactive compounds (NBCs) have shown properties that ameliorate the injury after IS and improve the patient's outcome, which has proven to be a potential therapeutic strategy due to their neuroprotective effects. Hence, in the present study, we use both systems pharmacology and chemoinformatic analyses to identify which NBCs have the most potential to be used against IS in clinics. Our results identify that flavonoids and terpenoids are the most studied NBCs, and, mainly, salidrosides, ginkgolides A, B, C, and K, cordycepin, curcumin, baicalin, resveratrol, fucose, and cannabidiol, target the main pathological processes occurring in IS. However, the medicinal chemistry properties of such compounds demonstrate that only six fulfill such criteria. However, only cordycepin and salidroside possess properties as leader molecules, suggesting that these compounds may be considered in developing novel drugs against IS.
C1 [Gomez-Verjan, Juan Carlos; Zepeda-Arzate, Emmanuel Alejandro; Santiago-de-la-Cruz, Jose Alberto; Rivero-Segura, Nadia Alejandra] Inst Nacl Geriatria INGER, Direcc Invest, Blvd Adolfo Ruiz Cortines 2767, Mexico City 10200, Mexico.
   [Estrella-Parra, Edgar Antonio] Unidad Nacl Autonoma Mexico, Lab Fitoquim, UBIPRO, FES Iztacala, Ave Barrios 1, Tlalnepantla 54090, Mexico.
RP Rivero-Segura, NA (corresponding author), Inst Nacl Geriatria INGER, Direcc Invest, Blvd Adolfo Ruiz Cortines 2767, Mexico City 10200, Mexico.
EM jverjan@inger.gob.mx; bm.ezepeda@gmail.com;
   alberto.santiago@alumnos.uacm.edu.mx; estreparr@iztacala.unam.mx;
   nrivero@inger.gob.mx
RI Rivero-Segura, Nadia Alejana/ABE-5424-2020
OI Rivero-Segura, Nadia Alejana/0000-0002-2659-6864; Gomez Verjan, Juan
   Carlos/0000-0001-7186-8067; Santiago de la Cruz, José
   Alberto/0009-0002-5801-0319; Zepeda Arzate, Emmanuel
   Alejano/0009-0008-6447-4041
FU Consejo Nacional de Humanidades, Ciencias y Tecnologias, Mexico
   [319706]; Consejo Nacional de Humanidades Ciencias y Tecnologias
   (CONAHCYT), Mexico
FX This study was supported by the Consejo Nacional de Humanidades,
   Ciencias y Tecnologias, Mexico; Project 319706. The publication of this
   paper was conducted by the Instituto Nacional de Geriatria, Mexico, and
   financially supported by the Consejo Nacional de Humanidades, Ciencias y
   Tecnologias, Mexico; Project 319706. E.A.Z.-A. received a scholarship
   from the Consejo Nacional de Humanidades Ciencias y Tecnologias
   (CONAHCYT), Mexico project 319706, "ISe puedenrevertir el envejecimiento
   con farmacos?"
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NR 71
TC 6
Z9 7
U1 0
U2 13
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1424-8247
J9 PHARMACEUTICALS-BASE
JI Pharmaceuticals
PD OCT
PY 2023
VL 16
IS 10
AR 1376
DI 10.3390/ph16101376
PG 13
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA W2AO1
UT WOS:001089712100001
PM 37895847
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Liu, ZL
   Liu, YY
   Liu, CS
   Song, ZQ
   Li, Q
   Zha, QL
   Lu, C
   Wang, C
   Ning, ZC
   Zhang, YX
   Tian, C
   Lu, AP
AF Liu, Zhenli
   Liu, Yuanyan
   Liu, Chunsheng
   Song, Zhiqian
   Li, Qing
   Zha, Qinglin
   Lu, Cheng
   Wang, Chun
   Ning, Zhangchi
   Zhang, Yuxin
   Tian, Cheng
   Lu, Aiping
TI The chemotaxonomic classification of Rhodiola plants and its
   correlation with morphological characteristics and genetic taxonomy
SO CHEMISTRY CENTRAL JOURNAL
LA English
DT Article
DE Rhodiola plants; Morphological characteristic; Genetic taxonomy;
   Phytochemical taxonomy
ID ROSEA L. EXTRACT; ELECTROSPRAY-IONIZATION; PHENOLIC-COMPOUNDS;
   SALIDROSIDE; CONSTITUENTS; STRESS; ROOTS
AB Background: Rhodiola plants are used as a natural remedy in the western world and as a traditional herbal medicine in China, and are valued for their ability to enhance human resistance to stress or fatigue and to promote longevity. Due to the morphological similarities among different species, the identification of the genus remains somewhat controversial, which may affect their safety and effectiveness in clinical use.
   Results: In this paper, 47 Rhodiola samples of seven species were collected from thirteen local provinces of China. They were identified by their morphological characteristics and genetic and phytochemical taxonomies. Eight bioactive chemotaxonomic markers from four chemical classes (phenylpropanoids, phenylethanol derivatives, flavonoids and phenolic acids) were determined to evaluate and distinguish the chemotaxonomy of Rhodiola samples using an HPLC-DAD/UV method. Hierarchical cluster analysis (HCA) and principal component analysis (PCA) were applied to compare the two classification methods between genetic and phytochemical taxonomy.
   Conclusions: The established chemotaxonomic classification could be effectively used for Rhodiola species identification.
C1 [Liu, Zhenli; Song, Zhiqian; Li, Qing; Wang, Chun] China Acad Chinese Med Sci, Inst Basic Theory, Beijing 100700, Peoples R China.
   [Liu, Yuanyan; Liu, Chunsheng; Ning, Zhangchi; Zhang, Yuxin; Tian, Cheng] Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing Municipal Key Lab Basic Res Chinese Med, Beijing, Peoples R China.
   [Zha, Qinglin; Lu, Cheng; Lu, Aiping] China Acad Chinese Med Sci, Inst Basic Res Clin Med, Beijing 100700, Peoples R China.
   [Lu, Aiping] Hong Kong Baptist Univ, Sch Chinese Med, Kowloon Tong, Hong Kong, Peoples R China.
C3 China Academy of Chinese Medical Sciences; Institute of Basic Theory for
   Chinese Medicine, CACMS; Beijing University of Chinese Medicine;
   Institute of Basic Research In Clinical Medicine, CACMS; China Academy
   of Chinese Medical Sciences; Hong Kong Baptist University
RP Lu, AP (corresponding author), China Acad Chinese Med Sci, Inst Basic Res Clin Med, Beijing 100700, Peoples R China.
EM lap64067611@126.com
RI Zhang, Yuxin/PWG-6470-2026; lu, chenghong/MIQ-3356-2025; Zha,
   Qinglin/POY-3302-2026; LU, Aiping/JDX-0577-2023
OI Zhang, Yuxin/0000-0003-4067-1047; LU, Aiping/0000-0002-2303-0494
FU National Science Foundation of China [30772726, 30825047, 30902000,
   81001623]
FX This study was financially supported by the National Science Foundation
   of China (Project No. 30772726, No. 30825047, No. 30902000 and No.
   81001623).
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NR 29
TC 27
Z9 29
U1 3
U2 62
PU SPRINGEROPEN
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 1752-153X
J9 CHEM CENT J
JI Chem. Cent. J.
PD JUL 12
PY 2013
VL 7
AR 118
DI 10.1186/1752-153X-7-118
PG 8
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA 186HU
UT WOS:000322034100001
PM 23844866
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhou, ZB
   Zhao, MZ
   Fang, HQ
   Lin, ZY
   Zheng, XR
   Zhuo, Y
   Li, ZM
   Zhou, WM
   Wang, XL
AF Zhou, Zhibin
   Zhao, Mengzhen
   Fang, Huaqiang
   Lin, Ziyue
   Zheng, Xinrui
   Zhuo, Yi
   Li, Zimeng
   Zhou, Weiming
   Wang, Xiaolei
TI Conductive hydrogel with responsive release of Herbal-Derived carbon
   dots for neurovascular reconstruction in diabetic critical limb ischemia
SO CHEMICAL ENGINEERING JOURNAL
LA English
DT Article
DE Diabetes mellitus; Critical limb ischemia; Conductive hydrogel;
   Anti-inflammatory; Neurovascular reconstruction
ID DISEASE
AB Diabetic critical limb ischemia (CLI), a common complication of diabetes with high morbidity and amputation rates, has seriously endangered the patients' health and quality of life. Diabetic CLI is commonly characterized by inflammatory imbalance, vasculopathy, and neuropathy, which significantly impede tissue regeneration. Most biomaterials offer limited angiogenic functions, of which neuropathy treatment is still in its infancy. Herein, we report a composite conductive hydrogel (MSC@COP) by combining the salidroside-derived carbon dots (CDs)embedded magnesium silicate nanoflowers (MSC) with the PEDOT:PSS-based hydrogel. Responding to the lowpH environment of diabetic CLI, CDs and magnesium ions (Mg2+) are released to scavenge reactive oxygen species in the ischemic microenvironment and promote the M1-to-M2 polarization of macrophages to reshape the inflammatory environment. Meanwhile, the high conductivity of the hydrogel conferred by PEDOT:PSS not only repairs the endogenous electric field but also synergizes with CDs and Mg2+ to inhibit Schwann cell pyroptosis, improve the recruitment of Schwann cells, consequently promoting the dual reconstruction of neural and vascular tissues.
C1 [Zhou, Zhibin; Fang, Huaqiang; Zhou, Weiming] Nanchang Univ, Affiliated Hosp 2, Dept Vasc Surg, Nanchang 330006, Jiangxi, Peoples R China.
   [Zhou, Zhibin; Lin, Ziyue; Zheng, Xinrui; Zhuo, Yi; Li, Zimeng; Zhou, Weiming; Wang, Xiaolei] Nanchang Univ, Inst Translat Med, Natl Engn Res Ctr Bioengn Drugs & Technol, Nanchang 330088, Jiangxi, Peoples R China.
   [Zhao, Mengzhen; Wang, Xiaolei] Nanchang Univ, Sch Chem & Chem Engn, Nanchang 330088, Jiangxi, Peoples R China.
C3 Nanchang University; Nanchang University; Nanchang University
RP Zhou, WM; Wang, XL (corresponding author), Nanchang Univ, Inst Translat Med, Natl Engn Res Ctr Bioengn Drugs & Technol, Nanchang 330088, Jiangxi, Peoples R China.
EM zwmsubmit@126.com; wangxiaolei@ncu.edu.cn
RI Zhou, Zhibin/IST-0217-2023
FU Interdiscipline Innovation Fund project of Nanchang University
   [PYJX20230001]; Key Research and Development Program of Jiangxi Province
   [20212BBG73004]; National Natural Science Foundation of China
   [82060095]; Key Science and Technology Innovation Project of Jiangxi
   Provincial Health Commission [2024ZD005]; Second Affiliated Hospital of
   Nanchang University Funding Program [2023efyA02]; Natural Science
   Foundation in Jiangxi Province [20202BABL206008]
FX This study was supported by the Interdiscipline Innovation Fund project
   of Nanchang University (Grant No. PYJX20230001 to Xiaolei Wang) , the
   Key Research and Development Program of Jiangxi Province (Grant No.
   20212BBG73004 to Xiaolei Wang) , the National Natural Science Foundation
   of China (Grant No. 82060095 to Weimin Zhou) , Key Science and
   Technology Innovation Project of Jiangxi Provincial Health Commission
   (Grant No. 2024ZD005 to Weimin Zhou) , the Second Affiliated Hospital of
   Nanchang University Funding Program (Grant No.2023efyA02 to Weimin Zhou)
   and the Natural Science Foundation in Jiangxi Province (Grant No.
   20202BABL206008 to Weimin Zhou) ,.
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NR 59
TC 6
Z9 7
U1 15
U2 70
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 1385-8947
EI 1873-3212
J9 CHEM ENG J
JI Chem. Eng. J.
PD NOV 15
PY 2024
VL 500
AR 157265
DI 10.1016/j.cej.2024.157265
EA NOV 2024
PG 17
WC Engineering, Environmental; Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering
GA L4N1C
UT WOS:001350491300001
DA 2026-05-27
ER

PT J
AU Lee, KJ
   Song, NY
   Oh, YC
   Cho, WK
   Ma, JY
AF Lee, Kwang Jin
   Song, Na-Young
   Oh, You Chang
   Cho, Won-Kyung
   Ma, Jin Yeul
TI Isolation and Bioactivity Analysis of Ethyl Acetate Extract from Acer
   tegmentosum Using In Vitro Assay and On-Line Screening
   HPLC-ABTS+ System
SO JOURNAL OF ANALYTICAL METHODS IN CHEMISTRY
LA English
DT Article
ID HPLC; CONSTITUENTS
AB The Acer tegmentosum (3 kg) was extracted using hot water, and the freeze-dried extract powder was partitioned successively using dichloromethane (DCM), ethyl acetate (EA), butyl alcohol (n-BuOH), and water. From the EA extract fraction (1.24 g), five phenolic compounds were isolated by the silica gel, octadecyl silica gel, and Sephadex LH-20 column chromatography. Based on spectroscopic methods such as H-1-NMR, C-13-NMR, and LC/MS the chemical structures of the compounds were confirmed as feniculin (1), avicularin (2), (+)-catechin (3), (-)-epicatechin (4), and 6'-O-galloyl salidroside (5). Moreover, a rapid on-line screening HPLC-ABTS + system for individual bioactivity of the EA-soluble fraction (five phenolic compounds) was developed. The results indicated that compounds 1 and 2 were first isolated from the A. tegmentosum. The anti-inflammatory activities and on-line screening HPLC-ABTS(+) assay method of these compounds in LPS-stimulated murine macrophages were rapid and efficient for the investigation of bioactivity of A. tegmentosum.
C1 [Lee, Kwang Jin; Song, Na-Young; Oh, You Chang; Cho, Won-Kyung; Ma, Jin Yeul] KIOM, KM Based Herbal Drug Dev Grp, Taejon 305811, South Korea.
C3 Korea Institute of Oriental Medicine (KIOM)
RP Ma, JY (corresponding author), KIOM, KM Based Herbal Drug Dev Grp, 1672 Yuseongdae Ro, Taejon 305811, South Korea.
EM jyma@kiom.re.kr
FU Study on Drug Efficacy Enhancement Using Bioconversion for Herbal
   Medicines Project [K14050]
FX This study was achieved at KM-Based Herbal Drug Development Group, KIOM.
   The authors also acknowledge the support from the "Study on Drug
   Efficacy Enhancement Using Bioconversion for Herbal Medicines" (K14050)
   Project.
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NR 23
TC 13
Z9 19
U1 0
U2 17
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2090-8865
EI 2090-8873
J9 J ANAL METHODS CHEM
JI J. Anal. Methods Chem.
PY 2014
VL 2014
AR 150509
DI 10.1155/2014/150509
PG 15
WC Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA AT6GA
UT WOS:000345036200001
PM 25386382
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Xie, YC
   Yang, AQ
   Li, NH
   Zheng, HW
   Zhong, Y
   Jin, YT
   Li, JB
   Ye, R
   Du, L
   Hu, F
AF Xie, Yicheng
   Yang, Anqi
   Li, Nihong
   Zheng, Huiwen
   Zhong, Ye
   Jin, Yuting
   Li, Jiabin
   Ye, Rui
   Du, Le
   Hu, Fan
TI Lapagyl mitigates UV-induced inflammation and immunosuppression
   via Foxp3+Tregs and CCL pathway: A single-cell transcriptomics study
SO PHYTOMEDICINE
LA English
DT Article
DE Lapagyl; Ultraviolet radiation; Photoaging; Skin inflammation; Skin
   immunosuppression; Foxp3 Tregs; CCL8
ID INNER BARK; T-CELLS; EXTRACT; ACTIVATION; OLEUROPEIN; RESPONSES;
   TAHEEBO; MAPK; ACID
AB Background: As the largest organ of the body, the skin is constantly subjected to ultraviolet radiation (UVR), leading to inflammations and changes that mirror those seen in chronological aging. Although various small molecule drugs have been explored for treating skin photoaging, they typically suffer from low stability and a high incidence of adverse reactions. Consequently, the continued investigation of photoaging treatments, particularly those utilizing herbal products, remains a critical clinical endeavor. One such herbal product, Lapagyl, is derived from the bark of the lapacho tree and possesses antioxidant efficacies that could be beneficial in combating skin photoaging. Purpose: This research aimed to evaluate the efficacy of the herbal product Lapagyl in combating UVR-induced skin photoaging. Additionally, it sought to unravel the mechanisms by which Lapagyl promotes the regeneration of the skin extracellular matrix. Methods: To investigate whether Lapagyl can alleviate skin aging and damage, a UVR radiation model was established using SKH-1 hairless mice. The dorsal skins of these mice were evaluated for wrinkle formation, texture, moisture, transepidermal water loss (TEWL), and elasticity. Pathological assessments were conducted to determine Lapagyl's efficacy. Additionally, single-cell sequencing and spectrum analysis were employed to elucidate the working mechanisms and primary components of Lapagyl in addressing UVR-induced skin aging and injury. Results: Lapagyl markedly reduced UVR-induced wrinkles, moisture loss, and elasticity decrease in SKH-1 mice. Single-cell sequencing demonstrated that Lapagyl corrected the imbalance in cell proportions caused by UVR, decreased UVR-induced ROS expression, and protected basal and spinous cells from skin damage. Additionally, Lapagyl effectively prevented the entry of inflammatory cells into the skin by reducing CCL8 expression and curtailed the UVR-induced formation of Foxp3+ regulatory T cells (Tregs) in the skin. Both pathological assessments and ex vivo skin model results demonstrated that Lapagyl effectively reduced UVR-induced damage to collagen and elastin. Spectrum analysis identified Salidroside as the primary compound remaining in the skin following Lapagyl treatment. Taken together, our study elucidated the skin protection mechanism of the herbal product Lapagyl against UVR damage at the cellular level, revealing its immunomodulatory effects, with salidroside identified as the primary active compound for skin. Conclusion: Our study provided a thorough evaluation of Lapagyl's protective effects on skin against UVR damage, delving into the mechanisms at the cellular level. We discovered that Lapagyl mitigates skin inflammation and immunosuppression by regulating Foxp3+ Tregs and the CCL pathway. These insights indicate that Lapagyl has potential as a novel therapeutic option for addressing skin photoaging.
C1 [Xie, Yicheng; Yang, Anqi; Zheng, Huiwen; Li, Jiabin] Zhejiang Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth, Sch Med,Dept Dermatol, Hangzhou 310052, Zhejiang Prov, Peoples R China.
   [Li, Nihong; Zhong, Ye; Jin, Yuting; Ye, Rui; Du, Le; Hu, Fan] Inertia Shanghai Biotechnol Co Ltd, UNISKIN Res Inst Skin Aging, Shanghai, Peoples R China.
   [Li, Nihong; Zhong, Ye; Jin, Yuting; Ye, Rui; Du, Le; Hu, Fan] DermaHlth Shanghai Biotechnol Co Ltd, Shanghai, Peoples R China.
   [Xie, Yicheng] 3333 Binsheng Rd, Hangzhou 310052, Zhejiang, Peoples R China.
   [Hu, Fan] 8 Huaihai Rd M,Lansheng Bldg 19F, Shanghai 200021, Peoples R China.
C3 Zhejiang University
RP Xie, YC (corresponding author), 3333 Binsheng Rd, Hangzhou 310052, Zhejiang, Peoples R China.; Hu, F (corresponding author), 8 Huaihai Rd M,Lansheng Bldg 19F, Shanghai 200021, Peoples R China.
EM ycxie@zju.edu.cn; hufan@uniskin.com
RI ; Hu, Fan/OQK-8178-2025; 谢, 诒诚/JVY-8205-2024
OI ZHENG, HUIWEN/0000-0001-5184-7226; Zhong, Ye/0009-0006-7074-1922
FU National Natural Sci- ence Foundation of China [82173819]; Zhejiang
   Province Research Project of Public Welfare Technology Application
   [LGF22H110001]
FX <BOLD>Funding</BOLD> This work was supported by a grant from the
   National Natural Sci- ence Foundation of China (No. 82173819 to YX) ,
   and by the Zhejiang Province Research Project of Public Welfare
   Technology Application (LGF22H110001 to HZ) .
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NR 52
TC 5
Z9 6
U1 3
U2 28
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD JUL
PY 2024
VL 129
AR 155679
DI 10.1016/j.phymed.2024.155679
EA MAY 2024
PG 16
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA SV8C8
UT WOS:001237306200001
PM 38701542
OA hybrid
DA 2026-05-27
ER

PT J
AU Kundisová, I
   Juan, ME
   Planas, JM
AF Kundisova, Ivana
   Emilia Juan, M.
   Planas, Joana M.
TI Simultaneous Determination of Phenolic Compounds in Plasma by
   LC-ESI-MS/MS and Their Bioavailability after the Ingestion of Table
   Olives
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE table olives; polyphenols; LC-ESI-MS/MS; bioavailability; plasma
ID RAT PLASMA; HYDROXYTYROSOL; ABSORPTION; METABOLITES; ACID
AB The role attributed to polyphenols on human health needs to be correlated with their plasmatic concentrations after food consumption. Then, a method based on liquid-liquid extraction followed by highly sensitive LC-ESI-MS/MS analysis was developed to determinate 16 phenolic compounds in plasma. Validation gave appropriate recovery, matrix effect (80%-120%), linear correlation (R-2 > 0.995), precision (<15%), LOQ (0.04-2.51 nM), and short chromatographic run. The method was verified after the administration of Arbequina table olives to rats. A single dose of destoned olives was given by gavage, and plasmatic concentrations of polyphenols were analyzed at 30 min. Interestingly, the profile found in plasma greatly differed from that of the olives. Plasmatic concentrations, from highest to lowest, were salidroside, p-coumaric acid, hydroxytyrosol, verbascoside, tyrosol, luteolin, and luteolin-7-O-glucoside. In conclusion, a simple and robust method was developed, enabling the identification and quantification of unaltered polyphenols in plasma after olives consumption, thus demonstrating its suitability for pharmacokinetics studies.
C1 [Kundisova, Ivana; Emilia Juan, M.; Planas, Joana M.] Univ Barcelona UB, Dept Bioquim & Fisiol, Barcelona 08028, Spain.
   [Kundisova, Ivana; Emilia Juan, M.; Planas, Joana M.] Univ Barcelona UB, Inst Recerca Nutr & Seguretat Alimentaria INSA UB, Barcelona 08028, Spain.
C3 University of Barcelona; University of Barcelona
RP Juan, ME; Planas, JM (corresponding author), Univ Barcelona UB, Dept Bioquim & Fisiol, Barcelona 08028, Spain.; Juan, ME; Planas, JM (corresponding author), Univ Barcelona UB, Inst Recerca Nutr & Seguretat Alimentaria INSA UB, Barcelona 08028, Spain.
EM mejuan@ub.edu; jmplanas@ub.edu
RI Planas, Joana M/M-3446-2014; Juan, M Emília/L-9458-2014
OI Planas, Joana M/0000-0001-7799-5884; Juan, M Emília/0000-0002-8756-2051
FU Ministerio de Economia y Competitividad [AGL2013-41188]; Generalitat de
   Catalunya, Spain [2014SGR1221, 2017SGR945]
FX This work was funded by grants AGL2013-41188 from Ministerio de Economia
   y Competitividad and 2014SGR1221 and 2017SGR945 from Generalitat de
   Catalunya, Spain.
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NR 30
TC 12
Z9 14
U1 7
U2 48
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD SEP 16
PY 2020
VL 68
IS 37
BP 10213
EP 10222
DI 10.1021/acs.jafc.0c04036
PG 10
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA NU1GW
UT WOS:000573390100037
PM 32833444
DA 2026-05-27
ER

PT J
AU Chen, DH
   Sun, H
   Shen, JQ
   Igor, LP
   Zheng, XY
   Hu, SP
   Xiang, Z
AF Chen, Dahui
   Sun, Hao
   Shen, Jiaqi
   Igor, Longo Phemba
   Zheng, Xiaoyong
   Hu, Shuping
   Xiang, Zheng
TI A Simple and Rapid UPLC Method for the Determination of Rosavin in Rat
   Plasma and Its Application to a Pharmacokinetic Study
SO JOURNAL OF CHROMATOGRAPHIC SCIENCE
LA English
DT Article
ID RHODIOLA-ROSEA L.; LIQUID-CHROMATOGRAPHY; GOLDEN ROOT; PERFORMANCE;
   EXTRACT; STRESS; SALIDROSIDE
AB Rosavin is a bioactive antidepressant component isolated from Rhodiola rosea L. In this work, an ultra-performance liquid chromatography (UPLC) method was established for the determination of rosavin in rat plasma. The chromatographic separation was achieved on a HSS T3 column (100 mm x 2.1 mm, 1.8 mu m) with a gradient mobile phase consisting of acetonitrile and water (0.1% formic acid). Plasma samples were processed with one-step protein precipitation. Rutin was chosen as internal standard and the detection wavelength was 249 nm. The pharmacokinetic parameters were analyzed using the drug and statistics software. The results showed that the established method has an excellent linearity in the range of 10-1,000 ng/mL (R-2 = 0.992) with a lower limit of quantification (10 ng/mL). The intra-and interday precision (relative standard deviation) were from 2.0 to 10.6% and the extraction recovery was 92.4-95.1%. The simple and rapid UPLC method was successfully applied to the pharmacokinetic and bioavailability study of rosavin in rats.
C1 [Chen, Dahui; Sun, Hao; Shen, Jiaqi; Zheng, Xiaoyong; Hu, Shuping; Xiang, Zheng] Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Peoples R China.
   [Igor, Longo Phemba] Wenzhou Med Univ, Sch Int Studies, Wenzhou 325035, Peoples R China.
C3 Wenzhou Medical University; Wenzhou Medical University
RP Xiang, Z (corresponding author), Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Peoples R China.
EM xzh0077@126.com
RI zheng, xiaoyong/OSI-7726-2025
FU Zhejiang Xinmiao Talents Program [2014R413028]; Nature Foundation
   Committee of Zhejiang Province, China [Y2110407]; Zhejiang Traditional
   Chinese Medicine Scientific Research fund project [2011ZA071]
FX The authors acknowledge the financial support from the Zhejiang Xinmiao
   Talents Program (2014R413028), Nature Foundation Committee of Zhejiang
   Province, China (Y2110407) and Zhejiang Traditional Chinese Medicine
   Scientific Research fund project (2011ZA071).
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NR 22
TC 5
Z9 6
U1 0
U2 17
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0021-9665
EI 1945-239X
J9 J CHROMATOGR SCI
JI J. Chromatogr. Sci.
PD AUG
PY 2016
VL 54
IS 7
SI SI
BP 1166
EP 1170
DI 10.1093/chromsci/bmw044
PG 5
WC Biochemical Research Methods; Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA ED8RN
UT WOS:000389138700014
PM 27048645
OA Bronze
DA 2026-05-27
ER

PT J
AU Wang, H
   Zhang, TZ
   Li, Y
   Wang, SM
AF Wang Huan
   Zhang Tianzhu
   Li Yu
   Wang Shumin
TI Effects of Ergosterol on COPD in Mice via JAK3/STAT3/NF-κB Pathway
SO INFLAMMATION
LA English
DT Article
DE Ergosterol; COPD; JAK3/STAT3/NF-kappa B
ID ACUTE LUNG INJURY; NF-KAPPA-B; INDUCED INFLAMMATION; SIGNALING PATHWAY;
   IN-VITRO; CELLS; MODEL; CHRYSOPHANOL; SALIDROSIDE; ACTIVATION
AB The present study was to evaluate the effect of ergosterol (ER) on CS (cigarette smoke)-induced chronic obstructive pulmonary disease (COPD) in mice. Fifty male ICR mice were randomly assigned to five groups: control group, CS group, CS + dexamethasone (Dex, 2 mg/kg) group, CS + ER (ER, 25 mg/kg) group, CS + ER (ER, 50 mg/kg). H&E staining demonstrated that ER inhibited CS-induced pathological injury in lung tissue. Besides, ER could restore the activities of superoxide dismutase (SOD) in serum and in the lung, catalase (CAT) in serum and reduce the content of malondialdehyde (MDA) in serum and in the lung. ER also inhibited pro-inflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1 beta (IL-1 beta) in serum and the lung. Furthermore, ER significantly inhibited the protein expression of JAK3/STAT3/NF-kappa B pathway in CS-induced mice. Our findings suggested that ER might effectively ameliorate the progression of COPD via JAK3/STAT3/NF-kappa B pathway in mice.
C1 [Wang Huan; Zhang Tianzhu; Li Yu] Jilin Agr Univ Jilin, Chinese Minist Educ Edible & Med Fungi, Engn Res Ctr, Changchun 130118, Peoples R China.
   [Wang Shumin] Changchun Univ Chinese Med, Changchun 130117, Jilin, Peoples R China.
C3 Changchun University of Chinese Medicine
RP Li, Y (corresponding author), Jilin Agr Univ Jilin, Chinese Minist Educ Edible & Med Fungi, Engn Res Ctr, Changchun 130118, Peoples R China.; Wang, SM (corresponding author), Changchun Univ Chinese Med, Changchun 130117, Jilin, Peoples R China.
EM fungi966@126.com; wangshuminch@126.com
OI Wang, Huan/0000-0002-1659-3918
FU National Twelve Five Major Drug Discovery Project [2011ZX09102-002-01];
   National Natural Science Foundation of China [81274037]
FX This work was supported by the National Twelve Five Major Drug Discovery
   Project (2011ZX09102-002-01). This research was supported by National
   Natural Science Foundation of China (No. 81274037).
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NR 37
TC 40
Z9 47
U1 1
U2 40
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0360-3997
EI 1573-2576
J9 INFLAMMATION
JI Inflammation
PD JUN
PY 2017
VL 40
IS 3
BP 884
EP 893
DI 10.1007/s10753-017-0533-5
PG 10
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA EU8CN
UT WOS:000401264900017
PM 28251448
DA 2026-05-27
ER

PT J
AU Shi, H
   Wang, FY
AF Shi Hui
   Wang Fangyu
TI Protective effects of bilobalide against ethanol-induced gastric ulcer
   in vivo/vitro
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Bilobalide; Ethanol-induced gastric ulcer; MAPK/NF-kappa B pathway
ID ACUTE LUNG INJURY; KAPPA-B PATHWAY; IN-VITRO; GASTROPROTECTIVE ACTIVITY;
   ANIMAL-MODELS; RATS; MICE; VIVO; SALIDROSIDE; MECHANISMS
AB Bilobalide (BI) has been widely known as a unique constituent extracted from Ginkgo biloba. The aim of the current study was to reveal the potential efficacy as well as the underlying mechanism of the action of BI on ethanol-induced lesion in gastric mucosa in vivo/vitro. Ethanol (0.2 ml/kg) was applied to induce gastric ulcer mice model. Our results indicated that treatment with BI markedly decreased the levels of interleukin-6 (IL-6), IL-1 beta and tumor necrosis factor-alpha (TNF-alpha) in vivo. Additionally, BI intervation exhibited elevated myeloperoxidase (MPO) level in stomach, increased superoxide dismutase (SOD) activity and decreased malonaldehyde (MDA) content in serum and stomach when compared with those of the model group. It could be also observed that inhibited MAPK/NF-kappa B pathway expressions occurred after BI treatment both in vivo and in vitro. Taken together, BI exerted a gastro-protective effect against gastric ulceration, which was presumed to be associated with MAPK/NF-kappa B pathway. (C) 2016 Published by Elsevier Masson SAS.
C1 [Shi Hui; Wang Fangyu] Southern Med Univ Guangzhou, Nanjing Clin Sch, Jinling Hosp, Dept Gastroenterol & Hepatol, Nanjing, Jiangsu, Peoples R China.
C3 Southern Medical University - China
RP Wang, FY (corresponding author), Southern Med Univ Guangzhou, Nanjing Clin Sch, Jinling Hosp, Dept Gastroenterol & Hepatol, Nanjing, Jiangsu, Peoples R China.
EM wangfy65@nju.edu.cn
RI /E-7198-2014
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   Chen T., 2015, INFLAMMATION
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NR 29
TC 36
Z9 46
U1 0
U2 29
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD JAN
PY 2017
VL 85
BP 592
EP 600
DI 10.1016/j.biopha.2016.11.068
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA EM7WK
UT WOS:000395522800069
PM 27903426
DA 2026-05-27
ER

PT J
AU Gong, Y
   Kang, PP
   Wang, JH
   Chen, Y
   Wei, ZL
AF Gong, Yi
   Kang, Peipei
   Wang, Junhui
   Chen, Yan
   Wei, Zhongliang
TI Neuroprotective potential of sevoflurane against isoflurane induced
   cognitive dysfunction in rats via anti-inflammatory and antioxidant
   effect
SO ACTA CIRURGICA BRASILEIRA
LA English
DT Article
DE Sevoflurane; Isoflurane; Cognitive Dysfunction; Oxidative Stress;
   Inflammation
ID OXIDATIVE STRESS; IMMUNE FUNCTION; IMPAIRMENT; CURCUMIN; SALIDROSIDE;
   ANESTHESIA; DEFICITS; DISEASE; MODEL
AB Purpose: Intravenous anesthetics have excellent analgesic activity without inducing the side effect in the respiratory system. The aim and objective of the current experimental study was to access the neuroprotective effect of sevoflurane against isoflurane induced cognitive dysfunction in rats. Methods: Isoflurane was used for induction the neurodysfunction in the rats, and rats received the oral administration of sevoflurane (2.5, 5 and 10 mg/kg). Morris water test was carried out for the estimation of cognitive function. Neurochemical parameters, antioxidant parameters and pro-inflammatory cytokines were also estimated. Results: Sevoflurane significantly (P < 0.001) altered the neurochemical parameters such as anti-choline acetyltransferase, acetylcholine esterase, acetylcholine, protein carbonyl, choline brain-derived neurotrophic factor, and amyloid beta; antioxidant parameters such as glutathione, superoxide dismutase, and malondialdehyde; pro-inflammatory cytokines include interleukin (IL-2, IL-10, IL-4, IL-6, IL-10, IL-1 beta), and tumor necrosis factor-alpha. Sevoflurane significantly reduced the activity of caspase-3. Conclusion: Sevoflurane exhibited the neuroprotection against the cognitive dysfunction in rats via anti-inflammatory and antioxidant mechanism.
C1 [Gong, Yi] Xiamen Univ, Sch Med, Dept Anesthesiol, Xiamen, Fujian, Peoples R China.
   [Kang, Peipei] Nantong Tumor Hosp, Dept Anesthesiol, Nantong, Jiangsu, Peoples R China.
   [Wang, Junhui] Taizhou Boai Hosp, Dept Anesthesiol, Taizhou, Zhangjiang, Peoples R China.
   [Chen, Yan] Xian Fourth Hosp, Dept Anesthesiol, Xian, Shaanxi, Peoples R China.
   [Wei, Zhongliang] Youjiang Med Univ Nationalities, Affiliated Hosp, Dept Anesthesia Baise, Guilin, Guangxi, Peoples R China.
C3 Xiamen University; Youjiang Medical University for Nationalities
RP Wei, ZL (corresponding author), Youjiang Med Univ Nationalities, Affiliated Hosp, Dept Anesthesia Baise, Guilin, Guangxi, Peoples R China.
EM wzl13877632127@sina.com
RI Wei, zhongliang/KIG-0124-2024; Wang, Junhui/AAA-2706-2021
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NR 28
TC 1
Z9 1
U1 0
U2 6
PU ACTA CIRURGICA BRASILEIRA
PI SAO PAULO
PA ALAMEDA RIO CLARO, 179-41, SAO PAULO, SP 01332-010, BRAZIL
SN 0102-8650
EI 1678-2674
J9 ACTA CIR BRAS
JI Acta Cir. Bras.
PY 2023
VL 38
AR e385523
DI 10.1590/acb385523
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CJ0Z8
UT WOS:001124780800001
PM 38055394
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Terletskaya, NV
   Korbozova, NK
   Grazhdannikov, AE
   Seitimova, GA
   Meduntseva, ND
   Kudrina, NO
AF Terletskaya, Nina, V
   Korbozova, Nazym K.
   Grazhdannikov, Alexander E.
   Seitimova, Gulnaz A.
   Meduntseva, Nataliya D.
   Kudrina, Nataliya O.
TI Accumulation of Secondary Metabolites of Rhodiola semenovii
   Boriss. In Situ in the Dynamics of Growth and Development
SO METABOLITES
LA English
DT Article
DE Rhodiola semenovii; secondary metabolites; ontogenesis; source-sink
   interaction
ID PLANT DEFENSE; ORGANS; SUGARS; GRAIN; YIELD; ACQUISITION; ALLOCATION;
   PATTERNS; STRESS; COSTS
AB Rhodiola semenovii Boriss. (Regel and Herder) might be a promising replacement for the well-known but endangered Rhodiola rosea L. In this research, the metabolic profile of R. semenovii, including drug-active and stress-resistant components, was studied in the context of source-sink interactions in situ in the dynamics of growth and development. Gas chromatography with mass spectrometric detection and liquid chromatography methods were used. The data obtained allow for assumptions to be made about which secondary metabolites determine the level of stress resistance in R. semenovii at different stages of ontogeny in situ. For the first time, an expansion in the content of salidroside in the above-ground organs, with its maximum value during the period of seed maturation, and a significant decrease in its content in the root were revealed in the dynamics of vegetation. These results allow us to recommend collecting the ground component of R. semenovii for pharmaceutical purposes throughout the seed development stage without damaging the root system.
C1 [Terletskaya, Nina, V; Korbozova, Nazym K.; Seitimova, Gulnaz A.; Meduntseva, Nataliya D.; Kudrina, Nataliya O.] Al Farabi Kazakh Natl Univ, Fac Biol & Biotechnol, Al Farabi Ave 71, Alma Ata 050040, Kazakhstan.
   [Terletskaya, Nina, V; Korbozova, Nazym K.; Seitimova, Gulnaz A.; Meduntseva, Nataliya D.; Kudrina, Nataliya O.] Al Farabi Kazakh Natl Univ, Fac Chem & Chem Technol, Al Farabi Ave 71, Alma Ata 050040, Kazakhstan.
   [Terletskaya, Nina, V; Korbozova, Nazym K.; Seitimova, Gulnaz A.; Kudrina, Nataliya O.] Inst Genet & Physiol, Al Farabi Ave 93, Alma Ata 050040, Kazakhstan.
   [Grazhdannikov, Alexander E.] Russian Acad Sci, NN Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, Novosibirsk 630090, Russia.
C3 Farabi University; Farabi University; Russian Academy of Sciences;
   Siberian Branch of the Russian Academy of Sciences; Vorozhtsov
   Novosibirsk Institute of Organic Chemistry
RP Terletskaya, NV; Kudrina, NO (corresponding author), Al Farabi Kazakh Natl Univ, Fac Biol & Biotechnol, Al Farabi Ave 71, Alma Ata 050040, Kazakhstan.; Terletskaya, NV; Kudrina, NO (corresponding author), Al Farabi Kazakh Natl Univ, Fac Chem & Chem Technol, Al Farabi Ave 71, Alma Ata 050040, Kazakhstan.; Terletskaya, NV; Kudrina, NO (corresponding author), Inst Genet & Physiol, Al Farabi Ave 93, Alma Ata 050040, Kazakhstan.
EM teni02@mail.ru; naz-ik@mail.ru; agrash@nioch.nsc.ru; sitigulnaz@mail.ru;
   nat.mdnt@gmail.com; kudrina_nat@mail.ru
RI Kudrina, Nataliya/JDV-8793-2023; Seitimova, Gulnaz/B-1744-2015;
   Terletskaya, Nina/T-4097-2018
OI Seitimova, Gulnaz/0000-0002-5157-1255; Meduntseva,
   Natalya/0000-0002-7700-1904; Terletskaya, Nina/0000-0003-3176-820X;
   Kuina, Natalya/0000-0002-0882-0447
FU Ministry of Education and Science of the Republic of Kazakhstan; 
   [AP08855699]
FX This research was carried out in the framework of the project AP08855699
   "The impact of abiotic stresses on the morphophysiological and
   phytochemical aspects of adaptation and biological activity of
   Kazakhstan plant Rhodiola semenovii Boriss." (2020-2022). This grant is
   funded by the Ministry of Education and Science of the Republic of
   Kazakhstan.
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NR 79
TC 13
Z9 14
U1 3
U2 20
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD JUL
PY 2022
VL 12
IS 7
AR 622
DI 10.3390/metabo12070622
PG 15
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 3H5OM
UT WOS:000832085600001
PM 35888746
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Wu, SB
   Xue, YT
   Yang, SJ
   Xu, CY
   Liu, CJ
   Liu, X
   Liu, JH
   Zhu, HJ
   Zhao, GR
   Yang, AD
   Qiao, JJ
AF Wu, Shengbo
   Xue, Yanting
   Yang, Shujuan
   Xu, Chengyang
   Liu, Chunjiang
   Liu, Xue
   Liu, Jiaheng
   Zhu, Hongji
   Zhao, Guang-Rong
   Yang, Aidong
   Qiao, Jianjun
TI Combinational quorum sensing devices for dynamic control in
   cross-feeding cocultivation
SO METABOLIC ENGINEERING
LA English
DT Article
DE Quorum sensing; Synchronized lysis circuit; Metabolic toggle switches;
   Microbial community; Biofuels; Glycosides; Synthetic biology
ID ESCHERICHIA-COLI; METABOLIC PATHWAY; COMMUNICATION; AUTOINDUCER;
   CONSORTIUM; CIRCUIT; SYSTEMS; FLUX
AB Quorum sensing (QS) offers cell density dependent dynamic regulations in cell culture through devices such as synchronized lysis circuit (SLC) and metabolic toggle switch (MTS). However, there is still a lack of studies on cocultivation with a combination of different QS-based devices. Taking the production of isopropanol and salidroside as case studies, we have mathematically modeled a comprehensive set of QS-regulated cocultivation schemes and constructed experimental combinations of QS devices, respectively, to evaluate their feasibility and optimality for regulating growth competition and corporative production. Glucose split ratio is proposed for the analysis of competition between cell growth and targeted production. Results show that the combination of different QS devices across multiple members offers a new tool with the potential to effectively coordinate synthetic microbial consortia for achieving high product titer in cross-feeding cocultivation. It is also evident that the performance of such systems is significantly affected by dynamic characteristics of chosen QS devices, carbon source control and the operational settings. This study offers insights for future applications of combinational QS devices in synthetic microbial consortia.
C1 [Wu, Shengbo; Xue, Yanting; Yang, Shujuan; Xu, Chengyang; Liu, Chunjiang; Liu, Xue; Liu, Jiaheng; Zhu, Hongji; Zhao, Guang-Rong; Qiao, Jianjun] Tianjin Univ, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China.
   [Wu, Shengbo; Liu, Chunjiang] Tianjin Univ, State Key Lab Chem Engn, Tianjin 300072, Peoples R China.
   [Yang, Aidong] Univ Oxford, Dept Engn Sci, Oxford OX1 3PJ, England.
   [Liu, Chunjiang; Zhao, Guang-Rong; Qiao, Jianjun] Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300072, Peoples R China.
   [Liu, Xue; Liu, Jiaheng; Zhu, Hongji; Zhao, Guang-Rong; Qiao, Jianjun] Tianjin Univ, Key Lab Syst Bioengn, Minist Educ, Tianjin 300072, Peoples R China.
   [Liu, Xue; Liu, Jiaheng; Zhu, Hongji; Zhao, Guang-Rong; Qiao, Jianjun] Tianjin Univ, Minist Educ, Frontiers Sci Ctr Synthet Biol, Tianjin 300072, Peoples R China.
C3 Tianjin University; Tianjin University; University of Oxford; Nankai
   University; Tianjin University; Collaborative Innovation Center of
   Chemical Science & Engineering Tianjin; Tianjin University; Tianjin
   University
RP Qiao, JJ (corresponding author), Tianjin Univ, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China.; Yang, AD (corresponding author), Univ Oxford, Dept Engn Sci, Oxford OX1 3PJ, England.
EM Aidong.Yang@eng.ox.ac.uk; jianjunq@tju.edu.cn
RI ; Wu, Shengbo/GRK-0088-2022; Yang, Aidong/M-2887-2013; Xu,
   Chengyang/PVE-5647-2026; Liu, Jiaheng/NYS-4190-2025
OI , Xue/0000-0003-3165-5539; Zhu, Hongji/0000-0001-5232-6844; Wu,
   Shengbo/0000-0001-7497-2935; 
FU National Key Research and Development Program of China [2020YFA0907900];
   Funds for Creative Research Groups of China [21621004]
FX The present study was supported by grants from National Key Research and
   Development Program of China (No. 2017YFD0201400), the Funds for
   Creative Research Groups of China (21621004), and National Key Research
   and Development Program of China (No. 2020YFA0907900).
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NR 53
TC 27
Z9 36
U1 4
U2 106
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1096-7176
EI 1096-7184
J9 METAB ENG
JI Metab. Eng.
PD SEP
PY 2021
VL 67
BP 186
EP 197
DI 10.1016/j.ymben.2021.07.002
EA JUL 2021
PG 12
WC Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology
GA UR9AI
UT WOS:000697032300009
PM 34229080
OA Green Submitted, Bronze
DA 2026-05-27
ER

PT J
AU Zhou, BG
   Zhao, HM
   Lu, XY
   Wang, X
   Zou, Y
   Xu, R
   Yue, HY
   Liu, Y
   Zuo, ZY
   Liu, DY
AF Zhou, Bu-gao
   Zhao, Hai-mei
   Lu, Xiu-yun
   Wang, Xin
   Zou, Yong
   Xu, Rong
   Yue, Hai-yang
   Liu, Yi
   Zuo, Zheng-yun
   Liu, Duan-yong
TI Erzhi Pill® Repairs Experimental Liver Injury via TSC/mTOR Signaling
   Pathway Inhibiting Excessive Apoptosis
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID FRUCTUS-LIGUSTRI-LUCIDI; HEPATIC OVAL CELLS; OLEANOLIC ACID; MTOR
   PATHWAY; HEPATECTOMY; EXPRESSION; GROWTH; SALIDROSIDE; ACTIVATION;
   PROTECTS
AB The present study aimed to investigate the mechanism of hepatoprotective effect of Erzhi Pill (EZP) on the liver injury via observing TSC/mTOR signaling pathway activation. The experimental liver injury was induced by 2-acetylaminofluorene (2-AAF) treatment combined with partial hepatectomy (PH). EZP treated 2-AAF/PH-induced liver injury by the therapeutic and prophylactic administration. After the administration of EZP, the activities of aspartic transaminase (AST), alanine aminotransferase (ALT), alkaline phosphatase (AKP), and gamma-glutamyl transpeptidase (gamma-GT) were decreased, followed by the decreased levels of hepatocyte apoptosis and caspase-3 expression. However, the secretion of albumin, liver weight, and index of liver weight were elevated. Microscopic examination showed that EZP restored pathological liver injury. Meanwhile, Rheb and mammalian target of rapamycin (mTOR) activation were suppressed, and tuberous sclerosis complex (TSC) expression was elevated in liver tissues induced by 2-AAF/PHx and accompanied with lower-expression of Bax, Notch1, p70S6K, and 4E-EIF and upregulated levels of Bcl-2 and Cyclin D. Hepatoprotective effect of EZP was possibly realized via inhibiting TSC/mTOR signaling pathway to suppress excessive apoptosis of hepatocyte.
C1 [Zhou, Bu-gao; Lu, Xiu-yun; Liu, Duan-yong] Jiangxi Univ Tradit Chinese Med, Sci & Technol Coll, Nanchang 330004, Jiangxi, Peoples R China.
   [Zhao, Hai-mei] Jiangxi Univ Tradit Chinese Med, Sch Basic Med Sci, Nanchang 330004, Jiangxi, Peoples R China.
   [Wang, Xin; Zou, Yong; Xu, Rong; Yue, Hai-yang; Liu, Yi] Jiangxi Univ Tradit Chinese Med, Dept Postgrad, Nanchang 330004, Jiangxi, Peoples R China.
   [Zuo, Zheng-yun] Jiangxi Univ Tradit Chinese Med, Sci & Technol Coll, Affiliated Hosp, Nanchang 330006, Jiangxi, Peoples R China.
C3 Nanchang Medical College; Jiangxi University of Traditional Chinese
   Medicine; Jiangxi University of Traditional Chinese Medicine; Jiangxi
   University of Traditional Chinese Medicine; Nanchang Medical College;
   Jiangxi University of Traditional Chinese Medicine
RP Liu, DY (corresponding author), Jiangxi Univ Tradit Chinese Med, Sci & Technol Coll, Nanchang 330004, Jiangxi, Peoples R China.; Zuo, ZY (corresponding author), Jiangxi Univ Tradit Chinese Med, Sci & Technol Coll, Affiliated Hosp, Nanchang 330006, Jiangxi, Peoples R China.
EM zzy61@163.com; liuduanyong@163.com
RI Duanyong, Liu/GRS-6297-2022
FU National Natural Science Foundation of China [81360525, 81460679];
   Natural Science Foundation of Jiangxi Province [20142BAB205077,
   2013BBG70018]
FX This research is supported in part by the Project of National Natural
   Science Foundation of China (nos. 81360525 and 81460679) and Natural
   Science Foundation of Jiangxi Province (nos. 20142BAB205077 and
   2013BBG70018).
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NR 83
TC 10
Z9 12
U1 0
U2 19
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2017
VL 2017
AR 5653643
DI 10.1155/2017/5653643
PG 15
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA EW3TH
UT WOS:000402425200001
PM 28638431
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU He, B
   Bai, X
   Tan, YM
   Xie, WT
   Feng, Y
   Yang, GY
AF He, Bo
   Bai, Xue
   Tan, Yumeng
   Xie, Wentao
   Feng, Yan
   Yang, Guang-Yu
TI Glycosyltransferases: Mining, engineering and applications in
   biosynthesis of glycosylated plant natural products
SO SYNTHETIC AND SYSTEMS BIOTECHNOLOGY
LA English
DT Article
DE Glycosyltransferases; Glycosylated plant natural products; Enzyme
   mining; Protein engineering; Biosynthesis
ID GENOME-WIDE ANALYSIS; GLUCOSE ANTHOCYANIDIN 3-O-GLUCOSYLTRANSFERASE;
   FAMILY-1 UDP-GLYCOSYLTRANSFERASES; CRYSTAL-STRUCTURES; ESCHERICHIA-COLI;
   STRUCTURAL BASIS; FUNCTIONAL-CHARACTERIZATION; SUSTAINABLE PRODUCTION;
   SAPONIN BIOSYNTHESIS; MOLECULAR-CLONING
AB UDP-Glycosyltransferases (UGTs) catalyze the transfer of nucleotide-activated sugars to specific acceptors, among which the GT1 family enzymes are well-known for their function in biosynthesis of natural product glycosides. Elucidating GT function represents necessary step in metabolic engineering of aglycone glycosylation to produce drug leads, cosmetics, nutrients and sweeteners. In this review, we systematically summarize the phylogenetic distribution and catalytic diversity of plant GTs. We also discuss recent progress in the identification of novel GT candidates for synthesis of plant natural products (PNPs) using multi-omics technology and deep learning predicted models. We also highlight recent advances in rational design and directed evolution engineering strategies for new or improved GT functions. Finally, we cover recent breakthroughs in the application of GTs for microbial biosynthesis of some representative glycosylated PNPs, including flavonoid glycosides (fisetin 3-O-glycosides, astragalin, scutellarein 7-O-glucoside), terpenoid glycosides (rebaudioside A, ginsenosides) and polyketide glycosides (salidroside, polydatin).
C1 [He, Bo; Bai, Xue; Tan, Yumeng; Xie, Wentao; Feng, Yan; Yang, Guang-Yu] Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, State Key Lab Microbial Metab, Joint Int Res Lab Metab & Dev Sci, Shanghai 200240, Peoples R China.
C3 Shanghai Jiao Tong University
RP Yang, GY (corresponding author), Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, State Key Lab Microbial Metab, Joint Int Res Lab Metab & Dev Sci, Shanghai 200240, Peoples R China.
EM yanggy@sjtu.edu.cn
FU National Key R&D Pro-gram of China [2020YFA0907900, 2018YFE0200501];
   National Natural Science Foundation of China [32030063]
FX This study was financially supported by the National Key R&D Pro-gram of
   China (2020YFA0907900, 2018YFE0200501) , and the National Natural
   Science Foundation of China (Grant number 32030063) .
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NR 185
TC 100
Z9 106
U1 19
U2 197
PU KEAI PUBLISHING LTD
PI BEIJING
PA 16 DONGHUANGCHENGGEN NORTH ST, Building 5, Room 411, BEIJING, DONGCHENG
   DISTRICT 100009, PEOPLES R CHINA
SN 2405-805X
J9 SYN SYST BIOTECHNO
JI Synth. Syst. Biotechnol.
PD MAR
PY 2022
VL 7
IS 1
BP 602
EP 620
DI 10.1016/j.synbio.2022.01.001
PG 19
WC Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology
GA ZL5EB
UT WOS:000763699100006
PM 35261926
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Jitkaroon, W
   Sutassanawichanna, W
   Srisuphan, R
   Wongprayoon, P
   Charoensuksai, P
   Rayanil, KO
AF Jitkaroon, Watcharapa
   Sutassanawichanna, Wirunya
   Srisuphan, Roongtiwa
   Wongprayoon, Pawaris
   Charoensuksai, Purin
   Rayanil, Kanok-on
TI A new acylated triterpene glycoside and cytotoxic constituents from
   Dolichandrone serrulata (Wall. ex DC.) Seem
SO NATURAL PRODUCT RESEARCH
LA English
DT Article
DE Dolichandrone serrulata; bignoniaceae; pentacyclic triterpenoid;
   cycloartane; cyclohexylethane derivative; glycoside
ID CLEROINDICINS
AB In this study, a new acylated triterpene glycoside, 3 alpha-O-stearoyl-28-[2 '-stearoyl-alpha-l-arabinopyranosyl]-olean-12-en-28-oic acid (1), was isolated from the flowers of Dolichandrone serrulata. In addition to this compound, eleven known compounds were also isolated, including a related pentacyclic triterpenoid: ursolic acid (2), two cycloartane triterpenoids: 24-methylenecycloartanol (3) and 24-methylenecycloartane-3,28-diol (4), three cyclohexylethane derivatives: (-)-rengyolone (5), (-)-cleroindicin C (6) and (-)-cleroindicin D (7), an iridoid: 6-O-trans-feruloyl catalpol (8), two phenylethanoid glycosides: salidroside (9) and verbascoside (10), and two steroids: beta-sitosterol (11) and beta-sitosterol-3-O-beta-d-glucopyranoside (12). The chemical structures of these compounds were determined by analysing their HRMS and NMR spectroscopic data. Additionally, their cytotoxic activities against NH22, HCT116, MCF7, MDA-MB-231, and HeLa cell lines were evaluated for all the compounds. Ursolic acid exhibited moderate cytotoxic activity against all cancer cell lines tested, particularly against HN22, MDA-MB-231, MCF-7, and HCT116 cells with IC50 values of approximately 19-34 mu M.
   [GRAPHICS]
   .
C1 [Jitkaroon, Watcharapa; Sutassanawichanna, Wirunya; Rayanil, Kanok-on] Silpakorn Univ, Dept Chem, Fac Sci, Nakhon Pathom, Thailand.
   [Srisuphan, Roongtiwa] Silpakorn Univ, Fac Pharm, Bioact Nat Resources Res Collaborat Excellence Pha, Nakhon Pathom, Thailand.
   [Wongprayoon, Pawaris; Charoensuksai, Purin] Silpakorn Univ, Fac Pharm, Dept Biomed & Hlth Informat & Bioact Nat Resources, Nakhon Pathom, Thailand.
C3 Silpakorn University; Silpakorn University; Silpakorn University
RP Rayanil, KO (corresponding author), Silpakorn Univ, Dept Chem, Fac Sci, Nakhon Pathom, Thailand.
OI Rayanil, Kanok-on/0000-0002-1133-1740
FU Faculty of Science, Silpakorn University [HCT116, HN22]
FX The authors thank Prof. Praneet Opanasopit, Faculty of Pharmacy,
   Silpakorn University, Thailand for providing the cell lines MCF7,
   MDA-MB-231, HeLa, HCT116, HN22, and hydroxypropyl-beta-cyclodextrin. The
   authors thank Assist. Prof. Dr. Veerawat Teeranachaidekul, Department of
   Pharmacy, Faculty of Pharmacy, Mahidol University, Thailand for
   providing HaCaT cells.
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NR 28
TC 0
Z9 0
U1 0
U2 7
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1478-6419
EI 1478-6427
J9 NAT PROD RES
JI Nat. Prod. Res.
PD JUL 3
PY 2025
VL 39
IS 13
BP 3657
EP 3664
DI 10.1080/14786419.2024.2306173
EA JAN 2024
PG 8
WC Chemistry, Applied; Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Pharmacology & Pharmacy
GA 4JI5X
UT WOS:001150074800001
PM 38263853
OA Green Submitted
DA 2026-05-27
ER

PT J
AU Shao, JH
   Chen, J
   Zhao, CC
   Shen, J
   Liu, WY
   Gu, WY
   Li, KH
AF Shao, Jian-Hua
   Chen, Jia
   Zhao, Chun-Chao
   Shen, Jie
   Liu, Wen-Yan
   Gu, Wen-Yan
   Li, Ke-Huan
TI Insecticidal and α-glucosidase inhibitory activities of chemical
   constituents from Viburnum fordiae Hance
SO NATURAL PRODUCT RESEARCH
LA English
DT Article
DE Viburnum fordiae Hance; chemical constituents; insecticidal activity;
   alpha-glucosidase inhibitory activity
ID STEREOCONTROLLED SYNTHESIS
AB The ethanolic extract of the stems of Viburnum fordiae Hance showed insecticidal and alpha-glucosidase inhibitory activities and then was fractionated by bioactivity-guided fractionation to obtain a rare C-13-norisoprenoid (1), together with a new phenolic glycoside (2), and seven known compounds, alangionoside C (3), pisumionoside (4), koaburaside (5), 3,5-dimethoxy-benzyl alcohol 4-O-beta-d-glucopyranoside (6), 3,4,5-trimethoxybenzyl-beta-d-glucopyranoside (7), arbutin (8), and salidroside (9). The previously undescribed compounds were elucidated as (3R,9R)-3-hydroxy-7,8-didehydro-beta-ionyl 9-O-alpha-d-arabinopyranosyl-(1 -> 6)-beta-d-glucopyranoside (1) and 2-(4-O-beta-d-glucopyranosyl)syringylpropane-1,3-diol (2) by spectroscopic data (H-1 and C-13 NMR, HSQC, HMBC, H-1-H-1 COSY, HSQC-TOCSY, HRESIMS, IR and ORD) and chemical methods. Compound 1 showed potent insecticidal effect against Mythimna separata with LD50 value of 140 mu g g(-1). Compounds 2, 5, 6, 8 and 9 showed varying alpha-glucosidase inhibitory activity with IC50 values ranging from 148.2 to 230.9 mu M.
   [GRAPHICS]
   .
C1 [Shao, Jian-Hua; Chen, Jia; Zhao, Chun-Chao; Gu, Wen-Yan; Li, Ke-Huan] Yangzhou Univ, Coinnovat Ctr Modern Prod Technol Grain Crops, Jiangsu Key Lab Crop Genet & Physiol, Yangzhou, Jiangsu, Peoples R China.
   [Zhao, Chun-Chao; Shen, Jie; Liu, Wen-Yan] Yangzhou Univ, Minist Educ China, Joint Int Res Lab Agr & Agri Prod Safety, Yangzhou, Jiangsu, Peoples R China.
C3 Yangzhou University; Yangzhou University
RP Chen, J; Zhao, CC (corresponding author), Yangzhou Univ, Coinnovat Ctr Modern Prod Technol Grain Crops, Jiangsu Key Lab Crop Genet & Physiol, Yangzhou, Jiangsu, Peoples R China.
EM chartishchen@hotmail.com; cczhao@yzu.edu.cn
RI liu, wenyan/PSM-1023-2026; zhao, chunchao/AAU-8036-2021
FU National Natural Science Foundation of China [31201563]
FX This work was supported by the National Natural Science Foundation of
   China [grant number 31201563].
CR [Anonymous], ZHONGH
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NR 20
TC 14
Z9 16
U1 3
U2 32
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1478-6419
EI 1478-6427
J9 NAT PROD RES
JI Nat. Prod. Res.
PD SEP 17
PY 2019
VL 33
IS 18
BP 2662
EP 2667
DI 10.1080/14786419.2018.1466130
PG 6
WC Chemistry, Applied; Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Pharmacology & Pharmacy
GA II9FJ
UT WOS:000475501100011
PM 29703100
DA 2026-05-27
ER

PT J
AU He, J
   Zhu, NL
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   Li, LF
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   Zhang, YL
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AF He, Jing
   Zhu, Nai-Liang
   Kong, Jing
   Peng, Ping
   Li, Lin-Fu
   Wei, Xiao-Lu
   Jiang, Yan-Yan
   Zhang, Yan-Ling
   Bian, Bao-Lin
   She, Gai-Mei
   Shi, Ren-Bing
TI A Newly Discovered Phenylethanoid Glycoside from Stevia
   rebaudiana Bertoni Affects Insulin Secretion in Rat INS-1 Islet β
   Cells
SO MOLECULES
LA English
DT Article
DE DS; insulin secretion; phenylethanoid glycoside; Stevia rebaudiana
   Bertoni; structure
ID IN-VIVO; STEVIOSIDE; IDENTIFICATION; ANTIOXIDANT; L.
AB The tea-like beverage Stevia rebaudiana Bertoni (Stevia) is popular in China because it reduces blood glucose and has a sweet taste. In this work, a comprehensive quality assessment of Stevia led to the discovery of five phenylethanoid glycosides, namely steviophethanoside (1), cuchiloside (2), salidroside (3), icariside D (4), and tyrosol (5). Of them, compound 1 is a novel compound. Mass spectrometry and NMR spectroscopy were employed to confirm the absolute configuration. A hydrolytic step with 4 N TFA at 95 degrees C for 4 h was used to confirm the monosaccharides. In addition, Discovery Studio 4.0 was used to predict the ADME and toxicity activity of compound 1. The results suggested that compound 1 was biocompatible and had poor toxicity, which was verified by rat INS-1 islet beta cells through an MTT assay. Meanwhile, a significant stimulatory effect on INS-1 cells was observed, which indicated a hypoglycemic effect of compound 1. This is the first report that describes a natural, novel, and hypoglycemic phenylethanoid glycoside in Stevia.
C1 [He, Jing; Zhu, Nai-Liang; Kong, Jing; Peng, Ping; Li, Lin-Fu; Jiang, Yan-Yan; Zhang, Yan-Ling; She, Gai-Mei; Shi, Ren-Bing] Beijing Univ Chinese Med, Sch Chinese Mat Med, Key Unit Exploring Effect Subst Class & Famous Pr, Beijing 102488, Peoples R China.
   [Zhu, Nai-Liang] Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 200293, Peoples R China.
   [Wei, Xiao-Lu; Bian, Bao-Lin] China Acad Chinese Med Sci, Inst Chinese Mat Med, Key Lab Beijing Identificat & Safety Evaluat Chin, Qual Stand, Beijing 100700, Peoples R China.
C3 Beijing University of Chinese Medicine; Chinese Academy of Medical
   Sciences - Peking Union Medical College; Institute of Medicinal Plant
   Development - CAMS; China Academy of Chinese Medical Sciences; Institute
   of Chinese Materia Medica, CACMS
RP She, GM; Shi, RB (corresponding author), Beijing Univ Chinese Med, Sch Chinese Mat Med, Key Unit Exploring Effect Subst Class & Famous Pr, Beijing 102488, Peoples R China.
EM hejing0932@163.com; zhu13liang@126.com; kj556776@163.com;
   pengping2177@126.com; lflfllf2001@126.com; xlwei@icmm.ac.cn;
   jyyjm1129@163.com; collean_zhang@163.com; blbian@icmm.ac.cn;
   shegaimei@126.com; shirb@126.com
RI Wei, Xiaolu/HTO-7227-2023
OI zhu, nailiang/0000-0001-7488-1291; She, Gai-Mei/0000-0003-1754-2140
FU innovative research team of the Beijing University of Chinese Medicine
   of China [2011-CXTD-12]; Twelfth Five-Year National Science and
   Technology Support Program [2012BAI29B06]; fundamental research funds of
   Beijing University of Chinese Medicine [2016-JYB-XS060]
FX This research was financially by the innovative research team of the
   Beijing University of Chinese Medicine of China (Grant no.
   2011-CXTD-12), the Twelfth Five-Year National Science and Technology
   Support Program (Grant no. 2012BAI29B06), and fundamental research funds
   of Beijing University of Chinese Medicine (2016-JYB-XS060).
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NR 40
TC 21
Z9 22
U1 0
U2 18
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD NOV
PY 2019
VL 24
IS 22
AR 4178
DI 10.3390/molecules24224178
PG 11
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA JU2TU
UT WOS:000501529700167
PM 31752141
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Wu, LP
   Georgiev, M
   Cao, H
   Nahar, L
   El-Seedi, HR
   Sarker, SD
   Xiao, JB
   Lu, BY
AF Wu, Lipeng
   Georgiev, Milen, I
   Cao, Hui
   Nahar, Lutfun
   El-Seedi, Hesham R.
   Sarker, Satyajit D.
   Xiao, Jianbo
   Lu, Baiyi
TI Therapeutic potential of phenylethanoid glycosides: A systematic review
SO MEDICINAL RESEARCH REVIEWS
LA English
DT Review
DE bioavailability; echinacoside; phenylethanoid glycosides; salidroside;
   verbascoside
ID PERFORMANCE LIQUID-CHROMATOGRAPHY; HUMAN INTESTINAL BACTERIA; LINKED
   CHITOSAN MICROSPHERES; FRAGRANS LOUR. FLOWERS; IN-VITRO; RAT PLASMA;
   CISTANCHE-TUBULOSA; PHENYLPROPANOID GLYCOSIDES; ANTIBACTERIAL ACTIVITY;
   OSMANTHUS-FRAGRANS
AB Phenylethanoid glycosides (PhGs) are generally water-soluble phenolic compounds that occur in many medicinal plants. Until June 2020, more than 572 PhGs have been isolated and identified. PhGs possess antibacterial, anticancer, antidiabetic, anti-inflammatory, antiobesity, antioxidant, antiviral, and neuroprotective properties. Despite these promising benefits, PhGs have failed to fulfill their therapeutic applications due to their poor bioavailability. The attempts to understand their metabolic pathways to improve their bioavailability are investigated. In this review article, we will first summarize the number of PhGs compounds which is not accurate in the literature. The latest information on the biological activities, structure-activity relationships, mechanisms, and especially the clinical applications of PhGs will be reviewed. The bioavailability of PhGs will be summarized and factors leading to the low bioavailability will be analyzed. Recent advances in methods such as bioenhancers and nanotechnology to improve the bioavailability of PhGs are also summarized. The existing scientific gaps of PhGs in knowledge are also discussed, highlighting research directions in the future.
C1 [Wu, Lipeng; Lu, Baiyi] Zhejiang Univ, Zhejiang Int Sci & Technol Cooperat Base Hlth Foo, Key Lab Agroprod Postharvest Handling,Minist Agr, Zhejiang Key Lab Agrofood Proc,Coll Biosyst Engn, Hangzhou, Peoples R China.
   [Wu, Lipeng; Lu, Baiyi] Zhejiang Univ, Fuli Inst Food Sci, Hangzhou, Peoples R China.
   [Wu, Lipeng; Lu, Baiyi] Zhejiang Univ, Ningbo Res Inst, Ningbo, Peoples R China.
   [Georgiev, Milen, I] Bulgarian Acad Sci, Stephan Angeloff Inst Microbiol, Lab Metabol, Plovdiv, Bulgaria.
   [Georgiev, Milen, I] Ctr Plant Syst Biol & Biotechnol, Plovdiv, Bulgaria.
   [Cao, Hui; Xiao, Jianbo] Univ Macau, SKL Qual Res Chinese Med, Inst Chinese Med Sci, Ave Univ, Taipa 999078, Macao, Peoples R China.
   [Nahar, Lutfun; Sarker, Satyajit D.] Liverpool John Moores Univ, Ctr Nat Prod Discovery CNPD, Sch Pharm & Biomol Sci, Liverpool, Merseyside, England.
   [El-Seedi, Hesham R.] Uppsala Univ, Dept Med Chem, Pharmacognosy Grp, Uppsala, Sweden.
   [El-Seedi, Hesham R.] Jiangsu Univ, Int Res Ctr Food Nutr & Safety, Zhenjiang, Jiangsu, Peoples R China.
C3 Zhejiang University; Zhejiang University; Zhejiang University; Bulgarian
   Academy of Sciences; Stephan Angeloff Institute of Microbiology,
   Bulgarian Academy of Sciences; University of Macau; Liverpool John
   Moores University; Uppsala University; Jiangsu University
RP Xiao, JB (corresponding author), Univ Macau, SKL Qual Res Chinese Med, Inst Chinese Med Sci, Ave Univ, Taipa 999078, Macao, Peoples R China.; Lu, BY (corresponding author), Zhejiang Univ, Coll Biosyst Engn & Food Sci, Hangzhou 310058, Peoples R China.
EM jianboxiao@yahoo.com; bylu@zju.edn.cn
RI lipeng, wu/AGX-5565-2022; Georgiev, Milen I/P-6948-2015; Nahar,
   Lutfun/AHE-0048-2022; Sarker, Satyajit/ABC-6278-2021; Cao,
   Hui/AAA-9324-2020
OI Georgiev, Milen I/0000-0001-5248-6135; Nahar,
   Lutfun/0000-0002-1157-2405; Sarker, Satyajit/0000-0003-4038-0514; Cao,
   Hui/0000-0002-0584-4734
FU Zhejiang Provincial Basic Public Welfare Research [LGN20C200010];
   Zhejiang Provincial Major RD Program [2019C02070]; National Major R and
   D Program of China [2017YFD0400200]; Special Project of Agricultural
   Product Quality Safety Risk Assessment [GJFP2019043]; European Regional
   Development Fund [BG05M2OP001-1.003-001-C01]; European Union [739582,
   664620]
FX Zhejiang Provincial Basic Public Welfare Research, Grant/Award Number:
   LGN20C200010; Zhejiang Provincial Major R&D Program, Grant/Award Number:
   2019C02070; National Major R and D Program of China, Grant/Award Number:
   2017YFD0400200; Special Project of Agricultural Product Quality Safety
   Risk Assessment, Grant/Award Number: GJFP2019043; European Regional
   Development Fund, Grant/Award Number: BG05M2OP001-1.003-001-C01 project;
   European Union's Horizon 2020 research and innovation programme,
   Grant/Award Number: SGA No 739582 under FPA No. 664620
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NR 275
TC 146
Z9 163
U1 10
U2 178
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0198-6325
EI 1098-1128
J9 MED RES REV
JI Med. Res. Rev.
PD NOV
PY 2020
VL 40
IS 6
BP 2605
EP 2649
DI 10.1002/med.21717
EA AUG 2020
PG 45
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA NX8JI
UT WOS:000557807200001
PM 32779240
OA Green Submitted
DA 2026-05-27
ER

PT J
AU Fan, ZL
   Pu, X
   Li, LL
   Li, Q
   Jiang, T
   Lu, LP
   Tang, JW
   Pan, M
   Zhang, LY
   Chai, YH
AF Fan, Zhiliang
   Pu, Xiang
   Li, Lailai
   Li, Qian
   Jiang, Te
   Lu, Liping
   Tang, Jingwen
   Pan, Mei
   Zhang, Liyan
   Chai, Yihui
TI Mechanism of Polygonum capitatum intervention in pulmonary
   fibrosis based on network pharmacology and molecular docking technology:
   A review
SO MEDICINE
LA English
DT Review
DE molecular docking; network pharmacology; pulmonary fibrosis; THL
ID CELLS; SALIDROSIDE; ACTIVATION; AUTOPHAGY; GROWTH
AB Pulmonary fibrosis (PF) is a serious interstitial disease that includes diffuse collagen deposition of lung tissue. Polygonum capitatum Buch.-Ham. ex D. Don (THL) is a traditional vaccine that has antibacterial and anti-inflammatory effects. In this research, to investigate the mechanism of action of THL in the intervention of pulmonary fibrosis by network pharmacology and molecular docking related research methods, in order to provide a theoretical basis for expanding the scope of THL medication. A total of 49 active ingredients were analyzed and screened in Cephalus cephalusis, including 35 pulmonary fibrosis targets, and 10 key targets such as ALB, EGFR were screened after software analysis. The molecular docking results showed that there were 44 binding energies less than -3 kcal<middle dot>mol(-1) in the 60 docking results, indicating that most proteins had strong binding energies with compounds. The key targets of KEGG enrichment analysis were mainly enriched in 20 core action pathways, such as hemostasisrelated pathway, regulation of kinase activity. This study shows that based on network pharmacology, the multicomponent- multitarget-multipathway effect of THL intervention in pulmonary fibrosis is discussed.
C1 [Fan, Zhiliang; Jiang, Te; Zhang, Liyan] Guizhou Univ Tradit Chinese Med, Sch Pharm, Guiyang, Peoples R China.
   [Pu, Xiang; Li, Lailai; Li, Qian; Chai, Yihui] Guizhou Univ Tradit Chinese Med, Sch Preclin Med, Guiyang 550025, Guizhou, Peoples R China.
   [Lu, Liping; Tang, Jingwen; Pan, Mei] Guizhou Weimen Pharmaceut Co Ltd, Tech Patent Dept, Guiyang, Peoples R China.
C3 Guizhou University of Traditional Chinese Medicine; Guizhou University
   of Traditional Chinese Medicine
RP Chai, YH (corresponding author), Guizhou Univ Tradit Chinese Med, Sch Preclin Med, Guiyang 550025, Guizhou, Peoples R China.
EM 18039501831@163.com; 314745595@qq.com; 1037541016@qq.com;
   1037541016@qq.com; 389938423@qq.com; 309527171@qq.com; cyun819@163.com;
   896221375@qq.com; zly1964@163.com; di410349931@163.com
FU Science and Technology Plan Project of Guiyang [(2020)-10-12]; National
   Natural Science Foundation of China [(2021)43-11]; Science and
   Technology Project of Guizhou Provincial Administration of Traditional
   Chinese Medicine [8260913];  [QZYY-2023-048]
FX This work was supported by the Science and Technology Plan Project of
   Guiyang [(2020)-10-12], Science and Technology Plan Project of Guiyang
   [(2021)43-11], National Natural Science Foundation of China (8260913),
   and Science and Technology Project of Guizhou Provincial Administration
   of Traditional Chinese Medicine (QZYY-2023-048).
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SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD SEP 15
PY 2023
VL 102
IS 37
AR e34912
DI 10.1097/MD.0000000000034912
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA W6CC2
UT WOS:001092474400015
PM 37713849
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Lv, YF
   Zhen, XY
   Liang, QQ
   Zhang, DF
   Yi, SM
   Li, XP
   Li, JR
AF Lv, Yanfang
   Zhen, Xiaoyan
   Liang, Qianqian
   Zhang, Defu
   Yi, Shumin
   Li, Xuepeng
   Li, Jianrong
TI Effects of polyphenols on the gel and digestive properties of Penaeus
   vannamei myosin after freezing
SO FOOD & FUNCTION
LA English
DT Article
ID CHEMICAL INTERACTIONS; MYOFIBRILLAR PROTEIN; SURIMI GELS; ACID; QUALITY;
   FOODS
AB Polyphenols could inhibit the freezing-induced denaturation of myosin, and affect its nutritional and functional properties, which have rarely been studied to date. Therefore, the effects of interactions between polyphenols and myosin after freezing on myosin gel and digestive properties were investigated using low field NMR, a texture analyzer, a dynamic rheometer, ultraviolet-visible spectra, scanning electron microscopy, LC-MS/MS, an automatic amino acid analyzer, etc. Hesperetin (HE), dihydroquercetin (DI), salidroside (SA), and mangiferin (MA) increased the water-holding capacity, non-flowable water content, gel strength, texture, storage modulus, and fractal dimensions of the myosin gel, while modifying its leading force. The results of scanning electron microscopy revealed that the surfaces of polyphenol groups were relatively smoother than those of the control group. Meanwhile, the four types of polyphenols under study significantly improved the gastric and gastrointestinal digestibility of myosin. Furthermore, they significantly increased the contents of essential, flavor, and total free amino acids, as well as the unique peptide numbers in myosin digestion products. This work provides reliable guidance for polyphenols to improve protein function and nutritional properties.
C1 [Lv, Yanfang; Zhen, Xiaoyan; Liang, Qianqian; Zhang, Defu; Yi, Shumin; Li, Xuepeng; Li, Jianrong] Bohai Univ, Coll Food Sci & Technol, Jinzhou 121013, Peoples R China.
   [Liang, Qianqian] Shanghai Ocean Univ, Coll Food Sci, Shanghai 201306, Peoples R China.
C3 Bohai University; Shanghai Ocean University
RP Li, XP; Li, JR (corresponding author), Bohai Univ, Coll Food Sci & Technol, Jinzhou 121013, Peoples R China.
EM xuepengli8234@163.com; lijr6491@163.com
OI Li, xuepeng/0000-0002-2445-7158
FU National Natural Science Foundation of China [U20A2067]
FX This study was supported by the National Natural Science Foundation of
   China (U20A2067).
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NR 40
TC 14
Z9 15
U1 12
U2 117
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD JUL 17
PY 2023
VL 14
IS 14
BP 6624
EP 6635
DI 10.1039/d3fo00973d
EA JUL 2023
PG 12
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA M0RU2
UT WOS:001018176800001
PM 37395469
DA 2026-05-27
ER

PT J
AU Wang, J
   Li, WR
   Zhao, F
   Han, QQ
   Shan, LL
   Qian, YM
AF Wang, Jing
   Li, Wanrong
   Zhao, Fang
   Han, Qianqian
   Shan, Lingling
   Qian, Yumei
TI Sirt3 regulates NLRP3 and participates in the effects of plantainoside D
   on acute lung injury sepsis
SO AGING-US
LA English
DT Article
DE sirt3; NLRP3; sepsis; ALI
ID ISCHEMIA-REPERFUSION INJURY; SALIDROSIDE; MODEL; RATS
AB Sepsis, a common critical disease, has high morbidity and mortality. Acute lung injury (ALI) is one of the important complications of sepsis, its effective treatment measures remain scarce. The purpose of the present study was to search for the biomarker and effective treatment measures. Lipopolysaccharide (LPS) was used to establish sepsis induced ALI model in vivo and in vitro. Proteomics, immunoprecipitation, molecular docking techniques, and Sirt3 knockout (KO) mice and silence MLE-12 cells were used to search for biomarker and treatment measures for sepsis ALI. 38 differentially expressed proteins were found in the lung tissues of sepsis ALI mice, among which Sirt3 changed most. Further study found that Sirt3 could inhibit NLRP3 activation. Sirt3 KO or silence significantly aggravated sepsis induced ALI and MLE-12 cell injury. Plantainoside D (PD), an effective component of Plantago asiatica L., significantly improved sepsis induced ALI by regulation of Sirt3/NLRP3 pathway. In conclusion, Sirt3 may be the important molecular targets for sepsis ALI. PD could protect sepsis ALI via Sirt3/NLRP3 signal pathway. The findings provide a new treatment target for sepsis ALI and a potential treatment measure.
C1 [Wang, Jing; Li, Wanrong; Zhao, Fang; Han, Qianqian; Shan, Lingling; Qian, Yumei] Suzhou Univ, Inst Pharmaceut, Sch Biol & Food Engn, Pharmacol Res Ctr, Suzhou, Anhui, Peoples R China.
C3 Suzhou University
RP Wang, J; Shan, LL; Qian, YM (corresponding author), Suzhou Univ, Inst Pharmaceut, Sch Biol & Food Engn, Pharmacol Res Ctr, Suzhou, Anhui, Peoples R China.
EM hjwang@ahszu.edu.cn; sll300@ahszu.edu.cn; Qianyumei@ahszu.edu.cn
FU Youth fund of Natural Science Foundation of Anhui Province
   [2208085QH261]; Pharmaceutical Pharmacology Research Center
   [2021XJPT37ZC]; Research platform opening project of Suzhou University
   [2020ykf19]; International Cooperation Projects of Anhui Province
   [202104b11020017]; Overseas Students Innovation Program based Funding
   Project of Anhui Province at 2022 [20221CX034]
FX Youth fund of Natural Science Foundation of Anhui Province
   (2208085QH261); Pharmaceutical Pharmacology Research Center
   (2021XJPT37ZC); Research platform opening project of Suzhou University
   (2020ykf19); International Cooperation Projects of Anhui Province
   (202104b11020017), Overseas Students Innovation Program based Funding
   Project of Anhui Province at 2022 (20221CX034).
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TC 10
Z9 12
U1 1
U2 12
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
SN 1945-4589
J9 AGING-US
JI Aging-US
PD JUL 31
PY 2023
VL 15
IS 14
BP 6710
EP 6720
PG 11
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA O5XD1
UT WOS:001044526700010
PM 37494665
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Wang, C
   Lin, MX
   Yang, ZL
   Lu, XY
   Liu, YF
   Lu, HZ
   Zhu, J
   Sun, XM
   Gu, Y
AF Wang, Chang
   Lin, Mingxin
   Yang, Zhiliang
   Lu, Xueyao
   Liu, Yinfang
   Lu, Huizhi
   Zhu, Jiang
   Sun, Xiaoman
   Gu, Yang
TI Characterization of the endogenous promoters in Yarrowia
   lipolytica for the biomanufacturing applications
SO PROCESS BIOCHEMISTRY
LA English
DT Article
DE Endogenous promoters; Yarrowia lipolytica; Promoter library; Synthetic
   biology; Microbial cell factories
ID LIPID-ACCUMULATION; PATHWAY; NITROGEN; COA
AB Yarrowia lipolytica, an oleaginous yeast with the GRAS status, has been developed as a platform for the chemical production. Promoter engineering is an important approach to regulating gene expression at the transcriptional level, which is of great significance in constructing microbial cell factories. Although some work on promoter study has been carried out in Y. lipolytica, obtained achievements still need further replenishment and development, compared explicitly with Saccharomyces cerevisiae, Bacillus subtilis, and other microorganisms. For this, we screened 81 endogenous promoters in Y. lipolytica, mainly involved in carbon metabolism and nitrogen metabolism. As a result, we obtained 15 strong promoters, 41 medium strength promoters, and 25 weak promoters, with the strength spanning from 0.06 % to 1.60-fold of P-TEF promoter. Moreover, as a proof-of-concept, the identified promoter library was applied for expressing UDP-glycosyltransferase to produce salidroside, resulting in a production of 95.64 mg/l in shake flask, which is 3.92-times that of the parental strain. In general, our study provides a unique and available endogenous promoter library for Y. lipolytica.
C1 [Wang, Chang; Lin, Mingxin; Lu, Xueyao; Liu, Yinfang; Lu, Huizhi; Zhu, Jiang; Sun, Xiaoman; Gu, Yang] Nanjing Normal Univ, Sch Food Sci & Pharmaceut Engn, Nanjing 210023, Peoples R China.
   [Yang, Zhiliang] Zhejiang Hisun Pharmaceut Co Ltd, Zhejiang Key Lab Antifungal Drugs, Taizhou 318000, Peoples R China.
C3 Nanjing Normal University; Zhejiang Hisun Pharmaceutical Co., Ltd.
RP Sun, XM; Gu, Y (corresponding author), Nanjing Normal Univ, Sch Food Sci & Pharmaceut Engn, Nanjing 210023, Peoples R China.
EM xiaomansun@njnu.edu.cn; guyang@nnu.edu.cn
RI Lin, Mingxin/JNT-4208-2023; Wang, Chang/E-5303-2019
FU Natural Science Foundation of Jiangsu Province [BK20202002, BK20210572];
   National Natural Science Foundation of China [22108126]
FX This work was financially supported by the Natural Science Foundation of
   Jiangsu Province (BK20202002) and (BK20210572), and National Natural
   Science Foundation of China (22108126).
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Z9 22
U1 13
U2 92
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1359-5113
EI 1873-3298
J9 PROCESS BIOCHEM
JI Process Biochem.
PD JAN
PY 2023
VL 124
BP 245
EP 252
DI 10.1016/j.procbio.2022.11.023
EA DEC 2022
PG 8
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Engineering
GA 8Y7TE
UT WOS:000932896700009
DA 2026-05-27
ER

PT J
AU Guo, W
   Huang, QL
   Liu, H
   Hou, SL
   Niu, SH
   Jiang, Y
   Bao, XM
   Shen, Y
   Fang, X
AF Guo, Wei
   Huang, Qiulan
   Liu, Hao
   Hou, Shaoli
   Niu, Suhao
   Jiang, Yi
   Bao, Xiaoming
   Shen, Yu
   Fang, Xu
TI Rational Engineering of Chorismate-Related Pathways in Saccharomyces
   cerevisiae for Improving Tyrosol Production
SO FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
LA English
DT Article
DE tyrosol; Ehrlich pathway; shikimate pathway; chorismate; Saccharomyces
   cerevisiae
ID INTACT YEAST-CELLS; P-COUMARIC ACID; PYRUVATE DECARBOXYLASE; BIOCHEMICAL
   EVALUATION; ESCHERICHIA-COLI; STRAIN; SALIDROSIDE; ENZYME;
   HYDROXYTYROSOL; TRANSFORMATION
AB Tyrosol is extensively used in the pharmaceutical industry as an important natural product from plants. In this study, an exogenous pathway involved in catalyzing tyrosine to tyrosol was introduced into Saccharomyces cerevisiae. Furthermore, The pyruvate decarboxylase gene pdc1 was deleted to redirect the flux distribution at the pyruvate node, and a bifunctional NAD(+)-dependent fused chorismate mutase/prephenate dehydrogenase from E. coli (Ec TyrA) and its' tyrosine inhibition resistant mutant (EcTyrA(M53I/A354V)) were heterologously expression in S. cerevisiae to tuning up the chorismate metabolism effectively directed the metabolic flux toward tyrosol production. Finally, the tyrosol yield of the engineered strain GFT-4 was improved to 126.74 +/- 6.70 mg/g DCW at 48 h, increased 440 times compared with that of the control strain GFT-0 (0.28 +/- 0.01 mg/g DCW). The new synergetic engineering strategy developed in this study can be further applied to increase the production of high value-added aromatic compounds derived from aromatic amino acid or shikimate in S. cerevisiae
C1 [Guo, Wei; Huang, Qiulan; Niu, Suhao; Jiang, Yi; Shen, Yu; Fang, Xu] Shandong Univ, State Key Lab Microbial Technol, Qingdao, Shandong, Peoples R China.
   [Liu, Hao] Tianjin Univ Sci & Technol, Minist Educ, Key Lab Ind Fermentat Microbiol, Tianjin, Peoples R China.
   [Hou, Shaoli] Shandong Henglu Biol Technol Co Ltd, Jinan, Shandong, Peoples R China.
   [Bao, Xiaoming] Qilu Univ Technol, Sch Bioengn, State Key Lab Biobased Mat & Green Papermaking, Jinan, Shandong, Peoples R China.
C3 Shandong University; Tianjin University of Science & Technology; Qilu
   University of Technology
RP Fang, X (corresponding author), Shandong Univ, State Key Lab Microbial Technol, Qingdao, Shandong, Peoples R China.; Liu, H (corresponding author), Tianjin Univ Sci & Technol, Minist Educ, Key Lab Ind Fermentat Microbiol, Tianjin, Peoples R China.
EM liuhao@tust.edu.cn; fangxu@sdu.edu.cn
RI Fang, Xu/B-8313-2015
OI Fang, Xu/0000-0002-9196-5697
FU Major Program of Shandong Province Natural Science Foundation
   [ZR2018ZB0209]; Foundation of Key Laboratory of Industrial Fermentation
   Microbiology of the Ministry of Education [2018KF003]; Tianjin Key Lab
   of Industrial Microbiology (Tianjin University of Science Technology)
   [2018KF003]; Key Technologies R&D Program of Shandong Province
   [2018GSF121021]; 111 Project [B16030]; National Natural Science
   Foundation of China [31570040, 31870785]
FX This work was financially supported by the Major Program of Shandong
   Province Natural Science Foundation (No. ZR2018ZB0209), the Foundation
   of Key Laboratory of Industrial Fermentation Microbiology of the
   Ministry of Education and the Tianjin Key Lab of Industrial Microbiology
   (Tianjin University of Science & Technology) (No. 2018KF003), the Key
   Technologies R&D Program of Shandong Province (No. 2018GSF121021), the
   111 Project (No. B16030), and the National Natural Science Foundation of
   China (No. 31570040 and No. 31870785).
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NR 42
TC 35
Z9 42
U1 5
U2 75
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-4185
J9 FRONT BIOENG BIOTECH
JI Front. Bioeng. Biotechnol.
PD JUL 3
PY 2019
VL 7
AR 152
DI 10.3389/fbioe.2019.00152
PG 7
WC Biotechnology & Applied Microbiology; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Engineering
GA IG4AV
UT WOS:000473747400001
PM 31334226
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Li, YT
   Zhao, YY
   Li, XT
   Liu, TF
   Jiang, XW
   Han, F
AF Li, Yanting
   Zhao, Yangyang
   Li, Xintong
   Liu, Tianfeng
   Jiang, Xiwei
   Han, Fei
TI Characterization of global metabolic profile of Rhodiola
   crenulata after oral administration in rat plasma, urine, bile and
   feces based on UHPLC-FT-ICR MS
SO JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
LA English
DT Article
DE Metabolic profile; Rhodiola crenulata; In vivo; Metabolites;
   UHPLC-FT-ICR MS
ID PERFORMANCE LIQUID-CHROMATOGRAPHY; FLIGHT MASS-SPECTROMETRY;
   CHEMICAL-CONSTITUENTS; IDENTIFICATION; SALIDROSIDE; EXTRACT; MEDIATORS;
   DISCOVERY; MS/MS; ACID
AB Rhodiola crenulata has been widely used as a health food, antifatigue and antidepressant in China and many other countries for centuries. However, to date the metabolism of it in vivo still remains unclear. In this study, UHPLC-FT-ICR MS was used to analyze the major components and their metabolites in rats after oral administration of Rhodiola crenulata for the first time. A total of 179 constituents, including 37 prototype compounds and 142 metabolites (89 phase I metabolites and 53 phase II metabolites) were tentatively identified. The metabolic pathways included hydroxylation, deglycosylation, dehydrogenation, glucuronidation and sulphate conjugation. In summary, this study showed an insight into the metabolism of Rhodiola crenulata in vivo, which may provide helpful chemical information for better understanding the multiple functions of it. And also, the developed method could be used as a reliable strategy to study the metabolic profile for other traditional chinese medicines. (C) 2017 Elsevier B.V. All rights reserved.
C1 [Li, Yanting; Zhao, Yangyang; Li, Xintong; Liu, Tianfeng; Han, Fei] Shenyang Pharmaceut Univ, Sch Pharm, 103 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China.
   [Han, Fei] Liaoning Univ Tradit Chinese Med, Key Lab, Minist Educ TCM Viscera State Theory & Applicat, Shenyang 110016, Liaoning, Peoples R China.
   [Jiang, Xiwei] Shenyang Pharmaceut Univ, Sch Med Devices, 103 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China.
C3 Shenyang Pharmaceutical University; Liaoning University of Traditional
   Chinese Medicine; Shenyang Pharmaceutical University
RP Han, F (corresponding author), Shenyang Pharmaceut Univ, Sch Pharm, 103 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China.; Jiang, XW (corresponding author), Shenyang Pharmaceut Univ, Sch Med Devices, 103 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China.
EM jiangxiwei810616@163.com; hanfei_spu@163.com
RI Liu, Tianfeng/NRA-9206-2025
FU National Natural Science Foundation of China [81673573]; Open fund of
   Key Laboratory of Ministry of Education; National Natural Science
   Foundation of China [81673573]; Open fund of Key Laboratory of Ministry
   of Education
FX This research was supported by the National Natural Science Foundation
   of China (No. 81673573) and the Open fund of Key Laboratory of Ministry
   of Education for TCM Viscera-State Theory and Applications, Liaoning
   University of Traditional Chinese Medicine.
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NR 27
TC 24
Z9 26
U1 4
U2 53
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0731-7085
EI 1873-264X
J9 J PHARMACEUT BIOMED
JI J. Pharm. Biomed. Anal.
PD FEB 5
PY 2018
VL 149
BP 318
EP 328
DI 10.1016/j.jpba.2017.10.032
PG 11
WC Chemistry, Analytical; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Pharmacology & Pharmacy
GA FV1IV
UT WOS:000424315700040
PM 29132111
DA 2026-05-27
ER

PT J
AU Xu, BJ
   Chen, B
   Qi, XL
   Liu, SL
   Zhao, YB
   Tang, C
   Meng, XL
AF Xu, Binjie
   Chen, Bang
   Qi, Xiaoli
   Liu, Shunli
   Zhao, Yibing
   Tang, Ce
   Meng, Xianli
TI Genome-wide Identification and Expression Analysis of RcMYB Genes
   in Rhodiola crenulata
SO FRONTIERS IN GENETICS
LA English
DT Article
DE Rhodiola crenulata; MYB transcription factors family; genome-wide
   identification; gene expression analysis; WGCNA analysis
ID MYB TRANSCRIPTION FACTORS; STRESS TOLERANCE; ARABIDOPSIS; RESPONSES;
   PLANT; DIVERGENCE; REGULATORS; EVOLUTION; FAMILY; DNA
AB Modern research has proved that the main medicinal component of Rhodiola crenulata, which has a wide range of medicinal value, is its secondary metabolite salidroside. The MYB transcription factor family is widely involved in biosynthesis of second metabolism and other roles in the stress response in plants, so a genome-wide identification and analysis for this family in R. crenulata is worth conducting. In this research, genome-wide analysis identified 139 MYB genes based on conserved domains in the R. crenulata genome, and 137 genes were used to construct a phylogenetic tree and modified with expression files to reveal evolutionary characteristics. Physical and chemical characteristics, gene structure, and conserved motif analysis were also used to further analyze RcMYBs. Additionally, cis-acting elements related to transcription, hormone, and MYB binding were found in the promoter region of the selected RcMYBs. Four RcMYBs were cloned, sequenced, and their gene expression pattern was analyzed for further analysis of their functions. The research results lay the foundation for further research on the function of RcMYB and R. crenulata.
C1 [Xu, Binjie; Tang, Ce; Meng, Xianli] Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R China.
   [Xu, Binjie] China Resources Sanjiu Yaan Pharmaceut Co Ltd, Yaan, Peoples R China.
   [Chen, Bang; Qi, Xiaoli; Liu, Shunli; Zhao, Yibing] Chengdu Univ Tradit Chinese Med, Sch Med Technol, Chengdu, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; China Resources
   Group; Chengdu University of Traditional Chinese Medicine
RP Xu, BJ; Meng, XL (corresponding author), Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R China.; Xu, BJ (corresponding author), China Resources Sanjiu Yaan Pharmaceut Co Ltd, Yaan, Peoples R China.
EM binjiexu@outlook.com; xlm999@cdutcm.edu.cn
RI Xu, Binjie/GWN-1300-2022
FU National Natural Science Foundation of China [81973569]; Xinglin Talent
   Program of Chengdu University of TCM [030058042]
FX This study was supported by the National Natural Science Foundation of
   China (No. 81973569) and the Xinglin Talent Program of Chengdu
   University of TCM (No. 030058042).
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TC 12
Z9 13
U1 9
U2 173
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-8021
J9 FRONT GENET
JI Front. Genet.
PD MAR 31
PY 2022
VL 13
AR 831611
DI 10.3389/fgene.2022.831611
PG 12
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA 0V9IY
UT WOS:000788653900001
PM 35432456
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Ye, C
   Jin, M
   Jin, CS
   Jin, L
   Sun, JF
   Ma, YJ
   Zhou, W
   Li, G
AF Ye, Chao
   Jin, Mei
   Jin, Chunshi
   Jin, Lan
   Sun, Jinfeng
   Ma, Ying Jie
   Zhou, Wei
   Li, Gao
TI Inhibitory Effects of Chemical Constituents fromActinidia
   kolomiktaon LPS-Induced Inflammatory Responses
SO REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
LA English
DT Article
DE Lignan glycosides; Phenolic glycosides; Glycosides; Flavonoids;
   Anti-inflammatory activity
ID ACTINIDIA-KOLOMIKTA; ANTIOXIDANT; GLYCOSIDES; PHENOLICS; EXTRACTS;
   RHIZOMES; ARGUTA; ROOTS
AB Sixteen known compounds, including three lignan glycosides (1-3), seven phenolic glycosides (4-10), three glycosides (11-13), and three flavonoids (14-16), were isolated from the rhizomes ofActinidia kolomikta(Rupr. & Maxim.) Maxim., Actinidiaceae. Their structures were elucidated through extensive spectroscopic analyses and comparison with those reported in the literature. This study is the first confirmation of the presence of the twelve compounds (1-4,6-13) isolated from the Actinidiaceae family. The isolated compounds were evaluated for their inhibitory effects on NO, TNF-alpha, and IL-6 production in LPS-induced RAW264.7 cells. Among them, salidroside (9),D-threo-guaiacylglycerol 7-O-beta-D-glucopyranoside (10), andepi-afzelechin (15) exhibited the potent anti-inflammatory effect against NO, TNF-alpha, and IL-6. In addition, compound10showed significant inhibitory effects on COX-2 expression at 50 mu M, and compound15showed significant inhibitory effects on iNOS expression at 50 mu M. These results suggest that the anti-inflammatory activity ofA. kolomiktamight in part occur via the inhibition of the expression of the pro-inflammatory cytokines.
C1 [Ye, Chao; Jin, Chunshi; Jin, Lan; Sun, Jinfeng; Ma, Ying Jie; Zhou, Wei; Li, Gao] Yanbian Univ, Coll Pharm, Minist Educ, Key Lab Nat Resources Changbai Mt & Funct Mol, Yanji, Peoples R China.
   [Jin, Mei] Yanbian Univ Hosp, Dept Pharm, Yanji, Peoples R China.
   [Ma, Ying Jie] Univ Copenhagen, Lab Mol Med, Dept Clin Immunol, Rigshosp,Fac Hlth & Med Sci, Sect 7631, Copenhagen, Denmark.
C3 Yanbian University; Yanbian University; University of Copenhagen;
   Copenhagen University Hospital; Rigshospitalet
RP Zhou, W; Li, G (corresponding author), Yanbian Univ, Coll Pharm, Minist Educ, Key Lab Nat Resources Changbai Mt & Funct Mol, Yanji, Peoples R China.
EM zw2015@ybu.edu.cn; gli@ybu.edu.cn
RI ; ZHOU, WEI/HHC-2054-2022; Ma, Ying Jie/AAJ-4697-2021
OI Li, Gao/0000-0002-1722-8859; Jin, Lan/0000-0001-5702-0182; Sun,
   Jinfeng/0000-0002-5576-1654; Ye, Chao/0000-0001-9149-6635; Ma, Ying
   Jie/0000-0003-4003-2579
FU National Natural Science Foundation of China [81660699, 81660579,
   81760627]
FX This work was supported by the National Natural Science Foundation of
   China under Grant numbers (81660699, 81660579, and 81760627).
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NR 27
TC 8
Z9 10
U1 0
U2 10
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0102-695X
EI 1981-528X
J9 REV BRAS FARMACOGN
JI Rev. Bras. Farmacogn.-Braz. J. Pharmacogn.
PD FEB
PY 2020
VL 30
IS 1
BP 127
EP 131
DI 10.1007/s43450-020-00004-w
PG 5
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA LZ9PH
UT WOS:000541550400018
DA 2026-05-27
ER

PT J
AU Liao, ZH
   Qiu, F
   Zeng, JL
   Gu, L
   Wang, BJ
   Lan, XZ
   Chen, M
AF Liao, Zhihua
   Qiu, Fei
   Zeng, Junlan
   Gu, Li
   Wang, Bangjun
   Lan, Xiaozhong
   Chen, Min
TI A Novel UDP-Glycosyltransferase of Rhodiola crenulata Converts
   Tyrosol to Specifically Produce Icariside D2
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID SALIDROSIDE BIOSYNTHESIS; OVEREXPRESSION
AB Rhodiola crenulata is a Tibetan native herbal plant belonging to the family of Crassulaceae, which produces the pharmaceutical icariside D2 with the activities of inhibiting angiotensin-converting enzyme and killing leukemia cancer cells. In this study, we functionally characterized a novel UDP-glycosyltransferase (RcUGT1) that converted tyrosol to specifically produce icariside D2 from R. crenulata at molecular and biochemical levels. RcUGT1 was highly expressed in flowers and roots, while the icariside D2 content wasmuch higher in stems than that in other organs, suggesting the potential translocation of icariside D2 from flowers and roots to stems. The high production of icariside D2 in stems provided a reasonable suggestion to farmers to harvest stems instead of roots for icariside D2 production. Enzymatic assays of recombinant RcUGT1 indicated that it converted tyrosol to specifically form icariside D2, with the values of Km 0.97 +/- 0.10 mM, Vmax 286 +/- 8.26 pKat/mg, Kcat 0.01552 s(-1), and Kcat/Km 159.55 s(-1) M-1. Functional identification of RcUGT1 facilitated the icariside D2 production through metabolic engineering in plants or synthetic biology in microbes.
C1 [Liao, Zhihua; Gu, Li; Lan, Xiaozhong] Xizang Agr & Husb Coll, TAAHC SWU Med Plant Joint R&D Ctr, Nyingchi Of Tibet 860000, Peoples R China.
   [Liao, Zhihua; Qiu, Fei; Zeng, Junlan; Wang, Bangjun] Southwest Univ, Sch Life Sci, SWU TAAHC Med Plant Joint R&D Ctr,Minist Educ,Key, Chongqing Key Lab Plant Ecol & Resources Res Thre, Chongqing 400715, Peoples R China.
   [Chen, Min] Southwest Univ, Minist Educ, Coll Pharmaceut Sci, Key Lab Luminescent & Real Time Analyt Chem, Chongqing 400715, Peoples R China.
C3 Xizang Agricultural & Animal Husbandry University; Southwest University
   - China; Southwest University - China
RP Lan, XZ (corresponding author), Xizang Agr & Husb Coll, TAAHC SWU Med Plant Joint R&D Ctr, Nyingchi Of Tibet 860000, Peoples R China.; Chen, M (corresponding author), Southwest Univ, Minist Educ, Coll Pharmaceut Sci, Key Lab Luminescent & Real Time Analyt Chem, Chongqing 400715, Peoples R China.
EM lanxiaozhong@163.com; mminchen@swu.edu.cn
RI ; Zeng, Junlan/KFA-6761-2024
OI Liao, Zhihua/0000-0002-1283-4649; Chen, Min/0000-0002-0140-4192; Qiu,
   Fei/0000-0002-5040-8018; Zeng, Junlan/0000-0002-0062-1873; Gu,
   Li/0000-0001-9072-4704
FU NSFC [81660628, 31370317]; Sci-Tech Project of the Education Bureau of
   Xizang Autonomous Region (Quality Control and Improvement of Resource
   Plants for Tibetan Medicines); Xizang Agricultural and Husbandry College
   [YJS2016-1]
FX This work was financially supported by the NSFC projects (81660628 and
   31370317), the Sci-Tech Project of the Education Bureau of Xizang
   Autonomous Region (Quality Control and Improvement of Resource Plants
   for Tibetan Medicines), and the Ph.D. funding of Xizang Agricultural and
   Husbandry College (YJS2016-1).
CR Bai YF, 2016, METAB ENG, V35, P138, DOI 10.1016/j.ymben.2016.01.002
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NR 16
TC 9
Z9 9
U1 4
U2 44
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PY 2018
VL 2018
AR 7970590
DI 10.1155/2018/7970590
PG 8
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA GJ9WU
UT WOS:000435757400001
PM 30027099
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Chen, Y
   Jiang, W
   Chen, Y
   Chen, XL
   Chen, W
   Li, FT
   Li, YJ
   Yao, X
AF Chen, Yu
   Jiang, Wei
   Chen, Yuan
   Chen, Xiao-Lan
   Chen, Wei
   Li, Feng-Tao
   Li, Yong-Jun
   Yao, Xin
TI Protective effect of betulinic acid for treating unpredictable chronic
   mild stress-induced depression in mice by inhibiting brain RIP140
   activation
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Betulinic acid; depression; RIP140
ID TAIL SUSPENSION TEST; ACUTE LUNG INJURY; IN-VIVO; MODEL; SALIDROSIDE;
   CYTOKINES; BEHAVIOR; RECEPTOR; COMPLEX
AB The present study was designed to evaluate whether betulinic acid (BA) could exert an antidepressant-like effect in mice exposed to unpredictable chronic mild stress (UCMS) and to explain its underlying mechanisms. Behavioral changes, which was investigated through sucrose preference test (SPT), open field test (OFT), forced swimming test (FST) and tail suspension test (TST), indicated that BA (20 mg/kg, 40 mg/kg) could improve depression symptoms. Cytokines interleukin (IL)- 6, IL-1 beta and tumor necrosis factor (TNF)-alpha in hippocampus presented significant decreases with exposure to betulinic acid. The expressions of RIP140, p-NF-kappa Bp65, p-I kappa B alpha, p-IKK alpha and p-IKK beta were inhibited with BA (20 mg/kg, 40 mg/kg) treatment according to western blot analysis, while immunohistochemical analysis also exhibited certain alterations of RIP140, p-NF-kappa Bp65. The current results suggested the potential antidepressant-like roles of betulinic acid in the UCMS-induced mouse model via inhibiting brain RIP140 activation.
C1 [Chen, Yu; Chen, Yuan; Chen, Xiao-Lan; Chen, Wei; Li, Feng-Tao; Li, Yong-Jun] Jiangsu Anim Husb & Vet Coll, Taizhou 225300, Peoples R China.
   [Jiang, Wei] Taizhou Inst Food & Drug Control, Taizhou 225300, Peoples R China.
   [Yao, Xin] Soochow Univ, Affiliated Hosp 1, Dept Pharm, Suzhou 215006, Peoples R China.
C3 Soochow University - China
RP Jiang, W (corresponding author), Taizhou Inst Food & Drug Control, Taizhou 225300, Peoples R China.; Yao, X (corresponding author), Soochow Univ, Affiliated Hosp 1, Dept Pharm, Suzhou 215006, Peoples R China.
EM jiangwei0624@yeah.net; 2079-723733@qq.com
FU Policy Guidance Class Plan (Industrial-Academic-Research Cooperation) of
   Science and Technology of Jiangsu Province [BY2015066-01]
FX This project was supported by Policy Guidance Class Plan
   (Industrial-Academic-Research Cooperation) of Science and Technology of
   Jiangsu Province (BY2015066-01).
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NR 30
TC 3
Z9 5
U1 0
U2 6
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2017
VL 10
IS 12
BP 16492
EP 16498
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FR6XO
UT WOS:000419211000074
DA 2026-05-27
ER

PT J
AU Liu, H
   Lv, PZ
   Zhu, YJ
   Wu, HY
   Zhang, K
   Xu, FB
   Zheng, L
   Zhao, JM
AF Liu, Hui
   Lv, Peizhen
   Zhu, Yongjia
   Wu, Huayu
   Zhang, Kun
   Xu, Fuben
   Zheng, Li
   Zhao, Jinmin
TI Salidroside promotes peripheral nerve regeneration based on tissue
   engineering strategy using Schwann cells and PLGA: in vitro and
   in vivo
SO SCIENTIFIC REPORTS
LA English
DT Article
ID SPINAL-CORD-INJURY; REPAIR; TRANSPLANTATION
AB Salidriside (SDS), a phenylpropanoid glycoside derived from Rhodiola rosea L, has been shown to be neuroprotective in many studies, which may be promising in nerve recovery. In this study, the neuroprotective effects of SDS on engineered nerve constructed by Schwann cells (SCs) and Poly (lactic-co-glycolic acid) (PLGA) were studied in vitro. We further investigated the effect of combinational therapy of SDS and PLGA/SCs based tissue engineering on peripheral nerve regeneration based on the rat model of nerve injury by sciatic transection. The results showed that SDS dramatically enhanced the proliferation and function of SCs. The underlying mechanism may be that SDS affects SCs growth through the modulation of neurotrophic factors (BDNF, GDNF and CNTF). 12 weeks after implantation with a 12 mm gap of sciatic nerve injury, SDS-PLGA/SCs achieved satisfying outcomes of nerve regeneration, as evidenced by morphological and functional improvements upon therapy by SDS, PLGA/SCs or direct suture group assessed by sciatic function index, nerve conduction assay, HE staining and immunohistochemical analysis. Our results demonstrated the significant role of introducing SDS into neural tissue engineering to promote nerve regeneration.
C1 [Liu, Hui; Lv, Peizhen; Zhang, Kun; Xu, Fuben; Zheng, Li; Zhao, Jinmin] Guangxi Med Univ, Guangxi Engn Ctr Biomed Mat Tissue & Organ Regene, Nanning, Peoples R China.
   [Liu, Hui; Zheng, Li; Zhao, Jinmin] Guangxi Med Univ, Collaborat Innovat Ctr Guangxi Biol Med, Nanning, Peoples R China.
   [Lv, Peizhen] Guangxi Med Univ, Affiliated Hosp 3, Dept Spine Surg, Nanning, Peoples R China.
   [Zhu, Yongjia; Zhang, Kun; Zhao, Jinmin] Guangxi Med Univ, Affiliated Hosp 1, Dept Orthopaed Trauma & Hand Surg, Nanning, Peoples R China.
   [Wu, Huayu] Guangxi Med Univ, Sch Premed Sci, Dept Cell Biol & Genet, Nanning, Peoples R China.
   [Xu, Fuben; Zheng, Li] Guangxi Med Univ, Med & Sci Res Ctr, Nanning, Peoples R China.
   [Zhao, Jinmin] Guangxi Med Univ, Guangxi Key Lab Regenerat Med, Nanning, Peoples R China.
C3 Guangxi Medical University; Guangxi Medical University; Guangxi Medical
   University; Guangxi Medical University; Guangxi Medical University;
   Guangxi Medical University; Guangxi Medical University
RP Zheng, L; Zhao, JM (corresponding author), Guangxi Med Univ, Guangxi Engn Ctr Biomed Mat Tissue & Organ Regene, Nanning, Peoples R China.; Zheng, L; Zhao, JM (corresponding author), Guangxi Med Univ, Collaborat Innovat Ctr Guangxi Biol Med, Nanning, Peoples R China.; Zhao, JM (corresponding author), Guangxi Med Univ, Affiliated Hosp 1, Dept Orthopaed Trauma & Hand Surg, Nanning, Peoples R China.; Zheng, L (corresponding author), Guangxi Med Univ, Med & Sci Res Ctr, Nanning, Peoples R China.; Zhao, JM (corresponding author), Guangxi Med Univ, Guangxi Key Lab Regenerat Med, Nanning, Peoples R China.
EM zhengli224@163.com; zhaojinmin@126.com
RI ; zhu, yongjia/OGB-1312-2025; Zhao, Jinmin/LBH-0351-2024
OI Zheng, Li/0000-0002-9666-0024; Zhao, Jinmin/0000-0002-1047-8820
FU National Natural Science Foundation of China [81160221]; Innovation
   Project of Guangxi Graduate Education of China [YCSZ2015126]; Research
   Center for Regenerative Medicine
FX This work has been financially supported by National Natural Science
   Foundation of China (Grant No. 81160221) and Innovation Project of
   Guangxi Graduate Education of China (Grant No. YCSZ2015126). This work
   has been supported by Research Center for Regenerative Medicine.
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NR 33
TC 47
Z9 55
U1 0
U2 45
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JAN 5
PY 2017
VL 7
AR 39869
DI 10.1038/srep39869
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA EG6VG
UT WOS:000391183800001
PM 28054637
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhang, XY
   Jiang, QW
   Li, P
   Chang, ZY
   Li, F
AF Zhang, Xing-yue
   Jiang, Qi-wu
   Li, Ping
   Chang, Zhi-yong
   Li, Fei
TI The chemometrics analysis and integrated pharmacology approach to
   decipher the effect and mechanism between raw and processed cistanche
   tubulosa
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Cistanche tubulosa; Yellow-wine processing; Kidney-yang deficiency;
   Functional constipation; Spectrum-effect relationship
ID MODEL
AB Ethnopharmacological relevance: Cistanche tubulosa (CT) is the dried fleshy stem with scaly leaves of Cistanche tubiflora (Schenk) Wight, which has the effects of tonifying the kidney-yang, benefiting the vital essence and blood, and moisturizing the intestines and laxatives. There are differences in the activity of CT before and after processing, but the mechanism of processing is not clear. Aim of the study: The study aimed to compare the strength of action of CT before and after yellow-wine processing in the treatment of constipation and kidney yang deficiency and to identify the active ingredients responsible for the differences in activity before and after yellow-wine processing. Materials and methods: This study established the fingerprints of CT and PCT using HPLC to identify their shared components. Then efficacy of KYDS and FC were carried out to compare the differences between CT and PCT in terms of efficacy. Next, this study established the spectrum-effect relationship between the shared chemical components and the medical effects of CT and PCT using the gray correlation analysis and entropy methods. Ultimately, the activity of the analyzed chemical components was verified using the zebrafish model. Results: CT was more effective than PCT in promoting intestinal peristalsis, regulating gastrointestinal hormone levels, and thus treating FC. PCT was more effective than CT in improving the level of hormone indexes of the hypothalamus-pituitary-target gland axis, replenishing blood, and enhancing immunity. Through the analysis of the spectrum-effect relationship, it was finally found that 5, 6, 12 (tubuloside A), and 13 (isoacteoside) might be more closely related to the activity of tonifying kidney yang, and peaks 9, 10, and 11 (acteoside) are more closely associated with the treatment of constipation, and peaks 3 (salidroside), 4, 1, 2 (geniposidic acid), and 8 (echinacoside) were associated with both kidney yang tonic and treatment of constipation. At the same time, an activity verification experiment showed that echinacoside, geniposidic acid, and salidroside were effective in the treatment of FC and KYDS, while acteoside was very effective in the treatment of FC, and tubuloside A was significant in supplementing the blood, which validated the spectrum-effect relationship analysis. Conclusion: This study proved that the raw CT had a better laxative effect, while the yellow-wine processed CT had a better kidney-yang tonic effect; moreover, spectrum-effect relationships were established to analyze the chemical components leading to changes in the activity of CT before and after yellow-wine processing.
C1 [Zhang, Xing-yue; Jiang, Qi-wu; Li, Ping; Li, Fei] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 211198, Peoples R China.
   [Chang, Zhi-yong] Nanjing Univ Chinese Med, Jiangsu Prov Hosp Chinese Med, Affiliated Hosp, Dept Orthoped, Nanjing 210029, Jiangsu, Peoples R China.
   [Li, Fei] Xinjiang Med Univ, Coll Pharm, Urumqi 830011, Peoples R China.
C3 China Pharmaceutical University; Nanjing University of Chinese Medicine;
   Xinjiang Medical University
RP Li, P; Li, F (corresponding author), China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 211198, Peoples R China.; Chang, ZY (corresponding author), Nanjing Univ Chinese Med, Jiangsu Prov Hosp Chinese Med, Affiliated Hosp, Dept Orthoped, Nanjing 210029, Jiangsu, Peoples R China.
EM liping2004@126.com; changzhiyong1987@126.com; lifei@cpu.edu.cn
RI chang, zy/IQV-3632-2023
FU National Key Research and Development Program of China [2023YFC3502605];
   National Natural Science Foundation of China [82322072]
FX Acknowledgements This study was supported by grants from the
   National Key Research and Development Program of China
   (No.2023YFC3502605) and the National Natural Science Foundation of China
   (No. 82322072) .
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NR 26
TC 7
Z9 7
U1 11
U2 40
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
EI 1872-7573
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD JUN 28
PY 2024
VL 328
AR 118097
DI 10.1016/j.jep.2024.118097
EA MAR 2024
PG 14
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA QF9P5
UT WOS:001219584700001
PM 38531432
DA 2026-05-27
ER

PT J
AU Li, HL
   Chai, Z
   Shen, GX
   Li, CY
AF Li, Hong-Ling
   Chai, Zhi
   Shen, Garry X.
   Li, Chun-Yang
TI Polyphenol Profiles and Antioxidant Properties of Ethanol Extracts from
   Osmanthus Fragrans (Thunb.) Lour. Flowers
SO POLISH JOURNAL OF FOOD AND NUTRITION SCIENCES
LA English
DT Article
DE ethanol extracts of Osmanthus fragrans flowers; antioxidant; polyphenol
   profiles; cultured endothelial cells
ID IONIZATION MASS-SPECTROMETRY; PHENOLIC-COMPOUNDS; LIQUID-CHROMATOGRAPHY;
   VAR. AURANTIACUS; FLAVONOIDS; IDENTIFICATION; CAPACITIES
AB This study evaluated the antioxidant activity of ethanol extracts of Osmanthus fragrans (Thunb.) Lour. flowers (EOF) and identified phenolic compounds in EOF using liquid chromatography-mass spectrometry. Nine compounds, 3-O-caffeoylquinic acid, caffeic acid 4-O-glucoside, salidroside, 5-O-coumaroylquinic acid, 4-O-coumaroylquinic acid, acteoside, ligustroside, fucosterol and arjunolic acid were identified. To our knowledge, caffeic acid 4-O-glucoside, 5-O-coumaroylquinic acid and 4-O-coumaroylquinic acid have not been detected in EOF. In vitro antioxidant activity analysis demonstrated that EOF possessed strong DPPH and ABTS radicals scavenging activity with EC50 values at 0.26 +/- 0.06 mg/mL and 0.36 +/- 0.01 mg/mL, respectively, and reducing power with Ab(0.5) value at 13.04 +/- 0.16 mu g/mL. The value of oxygen radical absorbance capacity (ORAC) was 333.23 +/- 13.39 mu mol Trolox/g. Antioxidant activity assay in human umbilical vein endothelial cells (HUVEC) showed that the activity of superoxide dismutase (SOD) was significantly improved and the reactive oxygen species (ROS) was removed effectively from cells when treated with EOF of 300 similar to 3000 mu g/L.
C1 [Li, Hong-Ling; Chai, Zhi; Li, Chun-Yang] Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing, Jiangsu, Peoples R China.
   [Li, Hong-Ling; Li, Chun-Yang] Jiangsu Acad Agr Sci, Inst Farm Prod Proc, Dept Funct Food & Bioact Cpds, 50 Zhongling St, Nanjing 210014, Jiangsu, Peoples R China.
   [Shen, Garry X.] Univ Manitoba, Dept Internal Med, Winnipeg, MB R3E 3P4, Canada.
   [Shen, Garry X.] Univ Manitoba, Dept Human Nutr Sci, Winnipeg, MB R3E 3P4, Canada.
C3 Nanjing Agricultural University; Jiangsu Academy of Agricultural
   Sciences; University of Manitoba; University of Manitoba
RP Li, CY (corresponding author), Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing, Jiangsu, Peoples R China.; Li, CY (corresponding author), Jiangsu Acad Agr Sci, Inst Farm Prod Proc, Dept Funct Food & Bioact Cpds, 50 Zhongling St, Nanjing 210014, Jiangsu, Peoples R China.
EM lichunyang968@126.com
RI Chai, Zhi/KIG-1970-2024; Li, Chunyang/H-2324-2013
OI Li, Hongling/0000-0003-3293-3625; Li, Chunyang/0000-0002-1180-0869
FU Agricultural Technology Extension Foundation of Central Finance [TG (14)
   113]; Jiangsu Provincial Agriculture Self-Renovation Foundation [CX (14)
   2120]; Natural Science foundation of Jiangsu Province [BK20141386];
   China Scholarship Council [[2015/]3012]
FX This research was supported by grants from the Agricultural Technology
   Extension Foundation of Central Finance [TG (14) 113], the Jiangsu
   Provincial Agriculture Self-Renovation Foundation [CX (14) 2120], and
   the Natural Science foundation of Jiangsu Province (BK20141386). It is
   also supported by China Scholarship Council ([2015/]3012).
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NR 35
TC 12
Z9 14
U1 3
U2 52
PU INST ANIMAL REPRODUCTION & FOOD RESEARCH POLISH ACAD SCIENCES OLSZTYN
PI OLSZTYN
PA UL J TUWIMA 10, OLSZTYN, 10-747, POLAND
SN 1230-0322
EI 2083-6007
J9 POL J FOOD NUTR SCI
JI Pol. J. food Nutr. Sci.
PD DEC
PY 2017
VL 67
IS 4
BP 317
EP 325
DI 10.1515/pjfns-2017-0008
PG 9
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA FI8YO
UT WOS:000412289400008
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhao, LL
   Zhou, Z
   Zhu, CS
   Fu, ZH
   Yu, DS
AF Zhao, Lingling
   Zhou, Zheng
   Zhu, Chunsheng
   Fu, Zhihui
   Yu, Dongsheng
TI Luteolin alleviates myocardial ischemia reperfusion injury in rats via
   Siti1/NLRP3/NF-κB pathway
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE Luteolin, myocardial infarction, Siti1; NLRP3; NF-kappa B pathway
ID KINASE; INHIBITION; SALIDROSIDE
AB The purpose of this study was to investigate the effects of luteolin (Lu) on myocardial ischemia-reperfusion (I/R) injury in rats. I/R model was established by ligating left anterior descending branch of coronary artery in rats. Cardiac hemodynamic measurement, myocardial infarction and damage assessment, antioxidant enzymes activities analysis, and various biochemical indexes of myocardial tissue were measured. Finally, the expression of proteins levels of Siti1/NLRP3/NF-kappa B pathway of myocardial tissue in rat were measured by Western Blotting. Lu obviously reduced the myocardial infarction in rats. Compared with sham group, I/R rats showed significant increase in LDH and CK-MB levels. In Lu group, LDH and CK-MB in I/R rats significantly decreased. In addition, Lu significantly reduced leukocyte infiltration compared with the sham group. On the other hand, Lu pretreatment effectively decreased the levels of cytokines in serum. The Siti1/NLRP3/NF-kappa B pathway in I/R group was significantly imbalance that in I/R group. Lu significantly restored the above protein changes. Lu may reduce I/R by regulation of Sirt1/NLRP3/NF-kappa B pathway.
C1 [Zhao, Lingling; Zhou, Zheng; Zhu, Chunsheng; Fu, Zhihui; Yu, Dongsheng] Zhengzhou Univ, Dept Tradit Chinese Med, Affiliated Hosp 1, Zhengzhou 450052, Henan, Peoples R China.
C3 Zhengzhou University
RP Fu, ZH; Yu, DS (corresponding author), Zhengzhou Univ, Dept Tradit Chinese Med, Affiliated Hosp 1, Zhengzhou 450052, Henan, Peoples R China.
EM bucmfzh@126.com; dsyu2008@163.com
OI Zhou, Zheng/0000-0002-7485-1030
CR Bao WK, 2004, CARDIOVASC RES, V61, P548, DOI 10.1016/j.cardiores.2003.12.004
   Chen T, 2016, INFLAMMATION, V39, P483, DOI 10.1007/s10753-015-0272-4
   Deng XY, 2015, CHEM-BIOL INTERACT, V240, P22, DOI 10.1016/j.cbi.2015.08.001
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NR 12
TC 42
Z9 49
U1 0
U2 20
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD AUG
PY 2020
VL 85
AR 106680
DI 10.1016/j.intimp.2020.106680
PG 8
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA MJ5QA
UT WOS:000548143500033
PM 32544871
DA 2026-05-27
ER

PT J
AU Zhao, CC
   Shen, J
   Chen, J
   Shao, JH
   Li, KH
   Gu, WY
   Miao, BJ
AF Zhao, Chun-Chao
   Shen, Jie
   Chen, Jia
   Shao, Jian-Hua
   Li, Ke-Huan
   Gu, Wen-Yan
   Miao, Ben-Jie
TI Phenolic glycoside constituents from Brassica rapa flowers and
   their ?-glucosidase inhibitory activity
SO NATURAL PRODUCT RESEARCH
LA English
DT Article
DE Brassica rapa L; phenolic glycoside constituents; -glucosidase
   inhibitory activity
ID ALPHA-GLUCOSIDASE; LIQUID-CHROMATOGRAPHY; RED CABBAGE; PLANT; ACID
AB Two new phenolic glycoside compounds (1, 2) and ten known analogues (3?12) have been isolated from the ethanolic extract of Brassica rapa flowers and identified as 2-O-?-d-glucopyranosyl-(1S)-(4-methoxyphenyl)ethylene glycol (1), 2-(4-O-?-d-allopyranosyl)phenyl-ethanol (2), 2-O-?-d-glucopyranosyl-(1S)-phenylethylene glycol (3), 2-O-?-d-glucopyranosyl-(1R)-phenylethylene glycol (4), (Z)-p-coumaryl-O-?-d-glucopyranoside (5), phenyl-O-?-d-glucopyranoside (6), 2-phenylethyl-O-?-d-glucopyranoside (7), salidroside (8), 2-(2-hydroxyphenyl)ethanol-O-?-d-glucopyranoside (9), 4-methoxybenzyl-O-?-d-glucopyranoside (10), 2,4,6-trimethoxyphenyl-1-O-?-d-glucopyranoside (11) and sachaliside 1 (12). The structures of 1 and 2, including absolute configurations, were determined by spectroscopic data (H-1 NMR, C-13 NMR, HSQC, HMBC and ORD) and chemical methods. In addition, most of them exhibited inhibitory activity with IC50 values ranging from 14.43 to 50.20??M in comparison to the positive control acarbose (IC50?=?15.76??M) in intestinal ?-glucosidase inhibitory activity tests.
C1 [Zhao, Chun-Chao; Chen, Jia; Shao, Jian-Hua; Li, Ke-Huan; Gu, Wen-Yan; Miao, Ben-Jie] Yangzhou Univ, Coinnovat Ctr Modern Prod Technol Grain Crops, Jiangsu Key Lab Crop Genet & Physiol, Yangzhou, Jiangsu, Peoples R China.
   [Zhao, Chun-Chao; Shen, Jie] Yangzhou Univ, Minist Educ China, Joint Int Res Lab Agr & Agriprod Safety, Yangzhou, Jiangsu, Peoples R China.
C3 Yangzhou University; Yangzhou University
RP Zhao, CC; Shao, JH (corresponding author), Yangzhou Univ, Coinnovat Ctr Modern Prod Technol Grain Crops, Jiangsu Key Lab Crop Genet & Physiol, Yangzhou, Jiangsu, Peoples R China.; Zhao, CC (corresponding author), Yangzhou Univ, Minist Educ China, Joint Int Res Lab Agr & Agriprod Safety, Yangzhou, Jiangsu, Peoples R China.
EM cczhao@yzu.edu.cn; jhshao@yzu.edu.cn
RI zhao, chunchao/AAU-8036-2021
FU National Natural Science Foundation of China [31201563]
FX This work was supported by the National Natural Science Foundation of
   China [grant number 31201563].
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NR 26
TC 20
Z9 22
U1 2
U2 35
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1478-6419
EI 1478-6427
J9 NAT PROD RES
JI Nat. Prod. Res.
PD DEC 2
PY 2019
VL 33
IS 23
BP 3398
EP 3403
DI 10.1080/14786419.2018.1479704
PG 6
WC Chemistry, Applied; Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Pharmacology & Pharmacy
GA JC1AU
UT WOS:000489011700010
PM 29888963
DA 2026-05-27
ER

PT J
AU Wang, HQ
   Chen, L
   Zhang, LM
   Gao, XJ
   Wang, YH
   Tao, WW
AF Wang, Hanqing
   Chen, Li
   Zhang, Liming
   Gao, Xiaojuan
   Wang, Yinghua
   Tao Weiwei
TI Protective effect of Sophoraflavanone G on streptozotocin (STZ)-induced
   inflammation in diabetic rats
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Sophoraflavanone G; STZ Oxidative stress; Txnip/Trx/NF-kB
ID ACUTE LUNG INJURY; KAPPA-B ACTIVATION; OXIDATIVE STRESS;
   SOPHORA-FLAVESCENS; IN-VIVO; THIOREDOXIN; SALIDROSIDE; IMPAIRMENT;
   PATHWAYS; MODEL
AB The present study was designed to investigate the protective effect of Sophoraflavanone G (SG) on streptozotocin (STZ)-induced diabetic rats. The rats were intraperitoneally injected with STZ (35 mg/kg). 7 days later, the rats were intragastrically administered with Metformin (MET, 150 mg/kg), SG (20 mg/kg) or SG (40 mg/kg) once daily for consecutive 30 days. The animals were anaesthetized, the blood and liver samples were also collected for further assay. SG significantly decreased the serum levels of glucose, insulin, aspartate transaminase (AST), alanine aminotransferase (ALT). In addition, SG increased superoxide dismutase (SOD) activity and inhibited malondialdehyde (MDA) content in serum. SG also ameliorated the histopathological condition. Furthermore, SG attenuated the expressions of thioredoxin (Trx), thioredoxin-interacting protein (Txnip) and the phosphorylations of inhibitory kappa B kinase (IKK)alpha, IKKb, nuclear factor-kB inhibitory proteins (IkB)alpha, nuclear factor kB (NF-kB). These findings demonstrated that SG showed beneficial effects on STZ-induced diabetic rats. (C) 2016 Elsevier Masson SAS. All rights reserved.
C1 [Wang, Hanqing; Chen, Li; Zhang, Liming; Gao, Xiaojuan; Wang, Yinghua] Ningxia Med Univ, Coll Pharm, 1160 Shengli St, Ningxia 750004, Peoples R China.
   [Tao Weiwei] Nanjing Univ Chinese Med, Sch Basic Biomed Sci, Ctr Translat Syst Biol & Neurosci, Nanjing 210023, Jiangsu, Peoples R China.
C3 Ningxia Medical University; Nanjing University of Chinese Medicine
RP Wang, HQ (corresponding author), Ningxia Med Univ, Coll Pharm, 1160 Shengli St, Ningxia 750004, Peoples R China.; Tao, WW (corresponding author), Nanjing Univ Chinese Med, Sch Basic Biomed Sci, Ctr Translat Syst Biol & Neurosci, Nanjing 210023, Jiangsu, Peoples R China.
EM wwwhhq@163.com; taoweiweinanjing@126.com
RI Wang, Hanqing/JJD-8795-2023
OI Gao, Xiaojuan/0009-0008-5445-1380
FU National Natural Science Foundation of China [81460645, 81603227];
   Special Talents Foundation of Ningxia Medical University [XT201408]
FX This work was supported by the National Natural Science Foundation of
   China (No. 81460645, No. 81603227) and the Special Talents Foundation of
   Ningxia Medical University (No. XT201408).
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TC 13
Z9 15
U1 0
U2 15
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD DEC
PY 2016
VL 84
BP 1617
EP 1622
DI 10.1016/j.biopha.2016.10.113
PG 6
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA EF6JU
UT WOS:000390438100189
PM 27832995
DA 2026-05-27
ER

PT J
AU Soliman, MM
   Althobaiti, SA
   Sayed, S
AF Soliman, Mohamed Mohamed
   Althobaiti, Saed A.
   Sayed, Samy
TI Ameliorative impacts of Rhodiola rosea against hepatic toxicity induced
   by monosodium glutamate: role of inflammation-, oxidative-stress-, and
   apoptosis-associated markers
SO JOURNAL OF TAIBAH UNIVERSITY FOR SCIENCE
LA English
DT Article
DE Rhodiola rosea; liver dysfunction; monosodium glutamate; apoptosis;
   antioxidant; Nrf2 and HO-1 expression
ID ISCHEMIA-REPERFUSION INJURY; SALIDROSIDE; LIVER; RAT; ACID; DYSFUNCTION;
   PROTECTION; DISEASE; KIDNEY; DAMAGE
AB Current study examined the protective impact of Rhodiola rosea (R. rosea) extract on hepatic toxicity markers caused by MSG. MSG induced significant increases in hepatic stress biomarkers. There were significant declines in GSH, catalase and SOD levels, which were accompanied by substantial elevations in IL-1 beta, IL-6, and TNF-alpha. There was hepatic cellular damage, and upregulation of caspase-3 and a decrease in Bcl-2 expression. The hepatotoxic impacts of MSG were normalized by Rhodiola supplementation. R. rosea downregulated caspase-3 and upregulated HO-1 and Nrf2 mRNA expression. R. rosea regulated the immunoreactivity of COX-2, TGF-beta 1, and NFkB genes associated with hepatic toxicity. R. rosea extract normalized histopathological changes induced by MSG and restored hepatic architecture. R. rosea extract exhibited anti-apoptotic, antioxidant, and anti-inflammatory properties. In conclusion, R. rosea extract is a promising medication against hepatic toxicity induced by MSG, which works by regulating the different signaling pathways of inflammation-, oxidative-stress-, and apoptosis-associated markers.
C1 [Soliman, Mohamed Mohamed] Taif Univ, Dept Clin Lab Sci, Tarif, Saudi Arabia.
   [Althobaiti, Saed A.] Taif Univ, Turabah Univ Coll, Dept Biol, Taif, Saudi Arabia.
   [Sayed, Samy] Taif Univ, Univ Coll Ranyah, Dept Sci & Technol, Taif, Saudi Arabia.
   [Soliman, Mohamed Mohamed] Taif Univ, Dept Clin Lab Sci, Tarif 21995, Saudi Arabia.
C3 Taif University; Taif University; Taif University; Taif University
RP Soliman, MM (corresponding author), Taif Univ, Dept Clin Lab Sci, Tarif 21995, Saudi Arabia.
EM mmsoliman@tu.edu.sa
RI Althobaiti, Saed/GRS-4168-2022; Soliman, Mohamed Mohamed/ABJ-0997-2022;
   Sayed, Samy/AAD-2389-2020
OI Soliman, Mohamed Mohamed/0000-0001-7208-7123; Sayed,
   Samy/0000-0002-7002-568X
FU The authors would like to acknowledge the Deanship of Scientific
   Research, Taif University, for funding this work.; Deanship of
   Scientific Research, Taif University
FX The authors would like to acknowledge the Deanship of Scientific
   Research, Taif University, for funding this work.
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NR 59
TC 7
Z9 7
U1 3
U2 16
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1658-3655
J9 J TAIBAH UNIV SCI
JI J. Taibah Univ. Sci.
PD DEC 31
PY 2023
VL 17
IS 1
AR 2244749
DI 10.1080/16583655.2023.2244749
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA X0IS3
UT WOS:001095380200001
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Rahman, MA
   Akter, S
   Dorotea, D
   Mazumder, A
   Uddin, MN
   Hannan, MA
   Hossen, MJ
   Ahmed, MS
   Kim, W
   Kim, B
   Uddin, MJ
AF Rahman, Md. Ataur
   Akter, Sumaya
   Dorotea, Debra
   Mazumder, Arpita
   Uddin, Md. Naim
   Hannan, Md. Abdul
   Hossen, Muhammad Jahangir
   Ahmed, Md. Selim
   Kim, Woojin
   Kim, Bonglee
   Uddin, Md Jamal
TI Renoprotective potentials of small molecule natural products targeting
   mitochondrial dysfunction
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE kidney diseases; mitochondrial dysfunction; small molecule natural
   products; traditional medicine; renoprotective effect
ID ACUTE KIDNEY INJURY; OXIDATIVE STRESS; DIABETIC-NEPHROPATHY; CURCUMIN;
   PROTECTS; RESVERATROL; DAMAGE; INFLAMMATION; INHIBITION; BERBERINE
AB Kidney diseases, including acute kidney injury (AKI) and chronic kidney disease (CKD), have become critical clinical, socioeconomic, and public health concerns worldwide. The kidney requires a lot of energy, and mitochondria act as the central organelle for the proper functioning of the kidney. Mitochondrial dysfunction has been associated with the pathogenesis of AKI and CKD. Natural products and their structural analogs have been sought as an alternative therapeutic strategy despite the challenges in drug discovery. Many studies have shown that small-molecule natural products can improve renal function and ameliorate kidney disease progression. This review summarizes the nephroprotective effects of small-molecule natural products, such as berberine, betulinic acid, celastrol, curcumin, salidroside, polydatin, and resveratrol. Treatment with small-molecule natural products was shown to attenuate renal oxidative stress and mitochondrial DNA (mtDNA) damage and restore mitochondrial biogenesis and dynamics in the kidneys against various injury stimuli. Therefore, small-molecule natural products should be recognized as multi-target therapeutics and promising drugs to prevent kidney diseases, particularly those with mitochondrial dysfunction.
C1 [Rahman, Md. Ataur; Akter, Sumaya; Mazumder, Arpita; Uddin, Md. Naim; Hannan, Md. Abdul; Uddin, Md Jamal] ABEx Biores Ctr, Dhaka, Bangladesh.
   [Rahman, Md. Ataur; Kim, Bonglee] Kyung Hee Univ, Coll Korean Med, Dept Pathol, Seoul, South Korea.
   [Rahman, Md. Ataur; Kim, Woojin; Kim, Bonglee] Kyung Hee Univ, Coll Korean Med, Korean Med Based Drug Repositioning Canc Res Ctr, Seoul, South Korea.
   [Dorotea, Debra; Uddin, Md Jamal] Ewha Womans Univ, Coll Pharm, Grad Sch Pharmaceut Sci, Seoul, South Korea.
   [Hannan, Md. Abdul] Bangladesh Agr Univ, Dept Biochem & Mol Biol, Mymensingh, Bangladesh.
   [Hossen, Muhammad Jahangir] Patuakhali Sci & Technol Univ, Dept Anim Sci, Dumki, Patuakhali, Bangladesh.
   [Ahmed, Md. Selim] Patuakhali Sci & Technol Univ, Fac Anim Sci & Vet Med, Dept Med Surg & Obstet, Barisal, Bangladesh.
   [Kim, Woojin] Kyung Hee Univ, Coll Korean Med, Dept Physiol, Seoul, South Korea.
C3 Kyung Hee University; Kyung Hee University; Ewha Womans University;
   Bangladesh Agricultural University (BAU); Kyung Hee University
RP Uddin, MJ (corresponding author), ABEx Biores Ctr, Dhaka, Bangladesh.; Kim, B (corresponding author), Kyung Hee Univ, Coll Korean Med, Dept Pathol, Seoul, South Korea.; Kim, B (corresponding author), Kyung Hee Univ, Coll Korean Med, Korean Med Based Drug Repositioning Canc Res Ctr, Seoul, South Korea.; Uddin, MJ (corresponding author), Ewha Womans Univ, Coll Pharm, Grad Sch Pharmaceut Sci, Seoul, South Korea.
EM bongleekim@khu.ac.kr; hasan800920@gmail.com
RI Kim, Bonglee/AAH-9077-2020; Ahmed, Selim/ABI-4729-2022; Kim,
   Woojin/AAK-2464-2020; Akter, Sumaya/HSB-7540-2023; Rahman,
   Ataur/AAE-1071-2019; Hannan, Md. Abdul/V-5720-2019; Hossen, Muhammad
   Jahangir/JXM-1076-2024; Uddin, Jamal/W-3434-2017
OI Ahmed, Selim/0000-0002-9601-8031; Dorotea, Debra/0000-0002-5302-0617;
   Miah, Asaduzzaman/0000-0003-2966-249X; Akter,
   Sumaya/0009-0008-0407-7722; Rahman, Ataur/0000-0001-6649-3694; Hossen,
   Muhammad Jahangir/0000-0003-1030-5898; Uddin, Jamal/0000-0003-2911-3255
FU Basic Science Research Program through the National Research Foundation
   of Korea (NRF) - Ministry of Education [NRF-2020R1I1A2066868]; National
   Research Foundation of Korea (NRF) - Korea government (MSIT)
   [2020R1A5A2019413]; National Research Foundation [2020R1I1A1A01072879,
   2015H1D3A1062189]; Brain Pool program - Ministry of Science and ICT
   through the National Research Foundation, South Korea
   [2020H1D3A2A02110924]
FX This research was supported by Basic Science Research Program through
   the National Research Foundation of Korea (NRF) funded by the Ministry
   of Education (NRF-2020R1I1A2066868), the National Research Foundation of
   Korea (NRF) grant funded by the Korea government (MSIT) (No.
   2020R1A5A2019413). Additionally, this work acknowledges the National
   Research Foundation (No. 2020R1I1A1A01072879 and 2015H1D3A1062189), and
   the Brain Pool program funded by the Ministry of Science and ICT through
   the National Research Foundation (No. 2020H1D3A2A02110924), South Korea.
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NR 91
TC 23
Z9 25
U1 3
U2 36
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD JUL 15
PY 2022
VL 13
AR 925993
DI 10.3389/fphar.2022.925993
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 3K8DX
UT WOS:000834305900001
PM 35910356
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Chang, PK
   Yen, IC
   Tsai, WC
   Chang, TC
   Lee, SY
AF Chang, Pi-Kai
   Yen, I-Chuan
   Tsai, Wei-Cheng
   Chang, Tsu-Chung
   Lee, Shih-Yu
TI Protective Effects of Rhodiola Crenulata Extract on
   Hypoxia-Induced Endothelial Damage via Regulation of AMPK and ERK
   Pathways
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE Rhodiola crenulata; hypoxia; endothelial cell; endothelial NOS; ERK;
   AMPK
ID INFLAMMATORY-BOWEL-DISEASE; OBSTRUCTIVE SLEEP-APNEA; NITRIC-OXIDE;
   OXIDATIVE STRESS; CELL APOPTOSIS; HYPOXIA/REOXYGENATION INJURY;
   DYSFUNCTION; SALIDROSIDE; INDIVIDUALS; GLUTATHIONE
AB Rhodiola crenulata root extract (RCE) has been shown to possess protective activities against hypoxia both in vitro and in vivo. However, the effects of RCE on response to hypoxia in the endothelium remain unclear. In this study, we aimed to examine the effects of RCE in endothelial cells challenged with hypoxic exposure and to elucidate the underlying mechanisms. Human umbilical vein endothelial cells were pretreated with or without RCE and then exposed to hypoxia (1% O-2) for 24 h. Cell viability, nitric oxide (NO) production, oxidative stress markers, as well as mechanistic readouts were studied. We found that hypoxia-induced cell death, impaired NO production, and oxidative stress. These responses were significantly attenuated by RCE treatment and were associated with the activation of AMP-activated kinase and extracellular signal-regulated kinase 1/2 signaling pathways. In summary, we showed that RCE protected endothelial cells from hypoxic insult and suggested that R. crenulata might be useful for the prevention of hypoxia-associated vascular dysfunction.
C1 [Chang, Pi-Kai; Lee, Shih-Yu] Natl Def Med Ctr, Grad Inst Med Sci, Taipei 11490, Taiwan.
   [Chang, Pi-Kai] Natl Def Med Ctr, Triserv Gen Hosp, Div Colon & Rectal Surg, Dept Surg, Taipei 11490, Taiwan.
   [Yen, I-Chuan] Natl Def Med Ctr, Sch Pharm, Taipei 11490, Taiwan.
   [Tsai, Wei-Cheng; Lee, Shih-Yu] Natl Def Med Ctr, Grad Inst Aerosp & Undersea Med, Taipei 11490, Taiwan.
   [Chang, Tsu-Chung] Natl Def Med Ctr, Dept Biochem, Taipei 11490, Taiwan.
C3 National Defense Medical University; Tri-Service General Hospital;
   National Defense Medical University; National Defense Medical
   University; National Defense Medical University; National Defense
   Medical University
RP Lee, SY (corresponding author), Natl Def Med Ctr, Grad Inst Med Sci, Taipei 11490, Taiwan.; Lee, SY (corresponding author), Natl Def Med Ctr, Grad Inst Aerosp & Undersea Med, Taipei 11490, Taiwan.
EM pencil8850@mail.ndmctsgh.edu.tw; yenichuan@mail.ndmctsgh.edu.tw;
   j4418m@gmail.com; tcchang@mail.ndmctsgh.edu.tw;
   leeshihyuno1@mail.ndmctsgh.edu.tw
RI Lee, Shih-Yu/AAO-4110-2020
OI Lee, Shih-Yu/0000-0002-4713-6410
FU Ministry of National Defense-Medical Affairs Bureau [MAB-106-025,
   MAB-107-041, MAB-107-035]; Cheng Hsin General Hospital Taipei, Taiwan
   [CH-106-15]
FX This work was supported by Grants from the Ministry of National
   Defense-Medical Affairs Bureau (MAB-106-025 and MAB-107-041 to S.-Y.L.,
   MAB-107-035 to T.-C.C.) and the Cheng Hsin General Hospital (CH-106-15
   to T.-C.C.) Taipei, Taiwan.
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Z9 29
U1 2
U2 20
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD AUG
PY 2018
VL 19
IS 8
AR 2286
DI 10.3390/ijms19082286
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA GR7LE
UT WOS:000442869800138
PM 30081534
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Tao, WW
   Wang, HQ
   Su, Q
   Chen, YY
   Xue, WD
   Xia, BM
   Duan, JN
   Chen, G
AF Tao, Weiwei
   Wang, Hanqing
   Su, Qiang
   Chen, Yanyan
   Xue, Wenda
   Xia, Baomei
   Duan, Jinao
   Chen, Gang
TI Paeonol attenuates lipopolysaccharide-induced depressive-like behavior
   in mice
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Paeonol; LPS-induced depression; Inflammation
ID ACUTE LUNG INJURY; KAPPA-B; IN-VIVO; SALIDROSIDE; INFLAMMATION;
   EXPRESSION; CYTOKINES; RECEPTOR; STRESS
AB The present study was designed to detect the anti-depressant effects of paeonol and the possible mechanisms in the lipopolysaccharide-induced depressive-like behavior. Open-field test(OFT), tail suspension test(TST) and forced swimming test(FST) were used to evaluate the behavioral activity. The contents of 5-hydroxytryptamine (5-HT) and norepinephrine (NE) in mice hippocampus were determined by HPLC-ECD. Serum interleukin (IL)-1 beta, IL-6 and tumor necrosis factor (TNF)-alpha levels were evaluated by enzyme-linked immunosorbent assay (ELISA). Our results showed that LPS significantly decreased the levels of 5-HT and NE in the hippocampus. LPS also reduced open-field activity, as well as increased immobility duration in FST and TST. Paeonol administration could effectively reverse the alterations in the concentrations of 5-HT, NE and reduce the IL-6 and TNF-alpha levels. Moreover, paeonol effectively downregulated brain-derived neurotrophic factor (BDNF), tropomyosin-related kinase B (TrkB) and Nuclear factor-kappa B (NF-kappa B) in hippocampal. In conclusion, paeonol administration exhibited significant antidepressant-like effects in mice with LPS-induced depression. (C) 2016 Published by Elsevier Ireland Ltd.
C1 [Tao, Weiwei; Su, Qiang; Chen, Yanyan; Xue, Wenda; Xia, Baomei; Chen, Gang] Nanjing Univ Chinese Med, Sch Basic Biomed Sci, Ctr Translat Syst Biol & Neurosci, Nanjing 210023, Jiangsu, Peoples R China.
   [Tao, Weiwei; Duan, Jinao] Nanjing Univ Chinese Med, Jiangsu Collaborat Innovat Ctr Chinese Med Resour, Nanjing 210023, Jiangsu, Peoples R China.
   [Tao, Weiwei; Duan, Jinao] Nanjing Univ Chinese Med, Natl & Local Collaborat Engn Ctr Chinese Med Reso, Nanjing 210023, Jiangsu, Peoples R China.
   [Wang, Hanqing] Ningxia Med Univ, Coll Pharm, Ningxia 750004, Peoples R China.
C3 Nanjing University of Chinese Medicine; Nanjing University of Chinese
   Medicine; Nanjing University of Chinese Medicine; Ningxia Medical
   University
RP Chen, G (corresponding author), Nanjing Univ Chinese Med, Sch Basic Biomed Sci, Ctr Translat Syst Biol & Neurosci, Nanjing 210023, Jiangsu, Peoples R China.
EM chengang@njucm.edu.cn
RI ; Xue, Wenda/AAR-9273-2020; baomei, Xia/JSL-5441-2023; Wang,
   Hanqing/JJD-8795-2023
OI Chen, Gang/0000-0002-3507-1218; Wang, Hanqing/0000-0003-1010-6098
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NR 28
TC 47
Z9 53
U1 0
U2 57
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD APR 30
PY 2016
VL 238
BP 116
EP 121
DI 10.1016/j.psychres.2016.02.033
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA DL0ZT
UT WOS:000375362300018
PM 27086220
DA 2026-05-27
ER

PT J
AU Jin, HG
   Kim, AR
   Ko, HJ
   Lee, SK
   Woo, ER
AF Jin, Hong-Guang
   Kim, A. Ryun
   Ko, Hae Ju
   Lee, Sang Kook
   Woo, Eun-Rhan
TI Three New Lignan Glycosides with IL-6 Inhibitory Activity from Akebia
   quinata
SO CHEMICAL & PHARMACEUTICAL BULLETIN
LA English
DT Article
DE lignan glycoside; interleukin-6 (IL-6) inhibitory effect;
   Lardizabalaceae; Akebia quinata
ID PHENYLPROPANOID GLYCOSIDES; STEM BARK; NEOLIGNAN; CONSTITUENTS; SAPONINS
AB Three new lignan glycosides, akeqintoside A [7S,85)-7,8-dihydro-8-hydroxymethy1-7-(4-hydroxy-3-methoxyphenyl)-1'-benzofuranpropanol 2'-O-beta-D-glucopyranoside] (1), akeqintoside B [(7R,8R)-7,8-dihydro-8-hydroxymethy1-7-(4-hydroxy-3-methoxypheny1)-1'-(9'-methoxy-7'-propenyl) benzofuran 2'-O-beta-D-oglucopyranoside] (2), and akequintoside C [7R*,8R*-dihydroxy-7-(4-hydroxy-3-methoxypheny1)-glycerol 9-O-beta-D-(6'-O-caffeoyl)-glucopyranoside] (3) were isolated from Akebia quinata along with five known compounds, syringin (4), vanilloloside (5), salidroside (6), 3,4-dihydroxyphenylethyl alcohol 8-O-beta-D-glucopyranoside (7), and calceolarioside B (8). The structures of the compounds were identified based on one dimensional (1D)and 2D-NMR, including H-1-H-1 correlation spectroscopy (COSY), heteronuclear single quantum coherence (HSQC), heteronuclear multiple bond connectivity (HMBC) and nuclear Overhauser effect spectroscopy (NOESY) spectroscopic analyses. The inhibitory activity of these isolated compounds against interleukin-6 (IL-6) production in tumor necrosis factor-alpha (TNF-alpha) stimulated MG-63 cells was also examined.
C1 [Jin, Hong-Guang; Kim, A. Ryun; Ko, Hae Ju; Woo, Eun-Rhan] Chosun Univ, Coll Pharm, Kwangju 501759, South Korea.
   [Lee, Sang Kook] Seoul Natl Univ, Coll Pharm, Inst Nat Prod Res, Seoul 151742, South Korea.
   [Jin, Hong-Guang] Jilin Med Coll, Coll Pharm, Jilin 132013, Peoples R China.
C3 Chosun University; Seoul National University (SNU); Jilin Medical
   University
RP Woo, ER (corresponding author), Chosun Univ, Coll Pharm, Kwangju 501759, South Korea.
EM wooer@chosun.ac.kr
RI LEE, Keun Woo/PMF-8891-2026
FU Ministry of Food and Drug Safety [12172MFDS989]
FX This research was supported by a Grant (12172MFDS989) from Ministry of
   Food and Drug Safety in 2013. We thank Dr. K. D. Park, and Mr. S.-T.
   Hong at the Korea Basic Science Institute for Gwangju Center for their
   aid in obtaining the NMR and mass spectra.
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U2 26
PU PHARMACEUTICAL SOC JAPAN
PI TOKYO
PA 2-12-15 SHIBUYA, SHIBUYA-KU, TOKYO, 150-0002, JAPAN
SN 0009-2363
J9 CHEM PHARM BULL
JI Chem. Pharm. Bull.
PD MAR
PY 2014
VL 62
IS 3
BP 288
EP 293
DI 10.1248/cpb.c13-00668
PG 6
WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Pharmacology & Pharmacy; Chemistry
GA AB8RI
UT WOS:000332057300011
PM 24583784
OA gold
DA 2026-05-27
ER

PT J
AU Lin, XL
   Liu, YY
   Ma, LL
   Ma, XM
   Chen, ZY
   Chen, H
   Si, L
   Ma, XY
   Yu, ZL
   Chen, XH
AF Lin, Xiuli
   Liu, Yingying
   Ma, Lili
   Ma, Xiaomeng
   Chen, Zhaoyu
   Chen, Hao
   Si, Lei
   Ma, Xueying
   Yu, Zhiling
   Chen, Xiaohong
TI Amelioration of experimental autoimmune encephalomyelitis by Rhodiola
   rosea, a natural adaptogen
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Rhodiola rosea; Adaptogen; Cytokines activities; T cell response;
   Experimental autoimmune encephalomyelitis
ID MULTIPLE-SCLEROSIS; T-CELLS; TH17 CELLS; SALIDROSIDE; STAT3; MECHANISMS;
   PATHWAY; HELPER; IL-6; PATHOGENESIS
AB Adaptogens are stress-response modifiers which have been considered to exert important influences on cytokines activities and immune response. Here, we investigated the effects of Rhodiola rosea (R. rosea), a natural adaptogen on the experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). We found that R. rosea alleviated the severity of EAE as evaluated by clinical and histopathology scores. R. rosea decreased IL-6, sIL-6R, IFN-gamma and IL-17A in both serum and splenocytes supernatants while increased IL-4 in splenocytes supernatants of EAE mice. R. rosea also modulated the T cell response by inhibiting Th1 and Th17 cells, restoring Treg cells, combining with regulated Th17/Th1, Th17/Th2 and Th17/Treg ratios in the spleen, inguinal lymph nodes, brain and spinal cord of EAE mice. Furthermore, R. rosea regulated the expression of JAK1, JAK2, STAT3 and ROR gamma t in the spinal cord of EAE mice. Together, our findings suggested the adaptogenic effects of R. rosea on EAE, which may help to deepen the understanding of potential therapeutic values of traditional Chinese medicines for autoimmune diseases of CNS.
C1 [Lin, Xiuli; Liu, Yingying; Ma, Lili; Ma, Xiaomeng; Chen, Zhaoyu; Chen, Hao; Si, Lei; Ma, Xueying; Chen, Xiaohong] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Neurol, Guangzhou, Guangdong, Peoples R China.
   [Lin, Xiuli; Liu, Yingying; Ma, Lili; Ma, Xiaomeng; Chen, Zhaoyu; Chen, Hao; Si, Lei; Ma, Xueying; Chen, Xiaohong] Sun Yat Sen Univ, Affiliated Hosp 3, Multiple Sclerosis Res Ctr, Guangzhou, Guangdong, Peoples R China.
   [Yu, Zhiling] Hong Kong Baptist Univ, Sch Chinese Med, Ctr Canc & Inflammat Res, Hong Kong, Peoples R China.
C3 Sun Yat Sen University; Sun Yat Sen University; Hong Kong Baptist
   University
RP Chen, XH (corresponding author), Sun Yat Sen Univ, Affiliated Hosp 3, Dept Neurol, Guangzhou, Guangdong, Peoples R China.; Chen, XH (corresponding author), Sun Yat Sen Univ, Affiliated Hosp 3, Multiple Sclerosis Res Ctr, Guangzhou, Guangdong, Peoples R China.; Yu, ZL (corresponding author), Hong Kong Baptist Univ, Sch Chinese Med, Ctr Canc & Inflammat Res, Hong Kong, Peoples R China.
EM zlyu@hkbu.edu.hk; xiaohongchenzssy@aliyun.com
OI Ma, Xueying/0009-0007-8343-1090
FU National Natural Science Foundation of China (NSFC) [81971141,
   813111290]; Israel Science Foundation (ISF)
FX This work was supported by grants (to X Chen) from the National Natural
   Science Foundation of China (NSFC, No. 81971141), and the Israel Science
   Foundation (ISF) and the National Natural Science Foundation of China
   (NSFC) joint programme (No. 813111290).
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NR 68
TC 15
Z9 17
U1 0
U2 19
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD MAY
PY 2020
VL 125
AR 109960
DI 10.1016/j.biopha.2020.109960
PG 11
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA KU2DX
UT WOS:000519520000019
PM 32058218
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Song, N
   Xia, HL
   Xie, YR
   Guo, SK
   Zhou, R
   Shangguan, LL
   Zhuang, K
   Zhang, HY
   An, FR
   Zheng, XY
   Yao, L
   Yang, SH
   Chen, X
   Dai, J
AF Song, Na
   Xia, Huili
   Xie, Yaoru
   Guo, Shuaikang
   Zhou, Rong
   Shangguan, Lingling
   Zhuang, Kun
   Zhang, Huiyan
   An, Feiran
   Zheng, Xueyun
   Yao, Lan
   Yang, Shihui
   Chen, Xiong
   Dai, Jun
TI Semi-rational design and modification of phosphoketolase to improve the
   yield of tyrosol in Saccharomyces cerevisiae
SO SYNTHETIC AND SYSTEMS BIOTECHNOLOGY
LA English
DT Article
DE Tyrosol; D-Erythrose 4-phosphate; Phosphoketolase; PHK pathway
ID 3-DEOXY-D-ARABINO-HEPTULOSONATE-7-PHOSPHATE SYNTHASE; PATHWAY;
   BIOSYNTHESIS; SALIDROSIDE; EFFICIENCY; GENE
AB Tyrosol is an important component of pharmaceuticals, nutraceuticals, and cosmetics, and their biosynthetic pathways are currently a hot research topic. D-Erythrose 4-phosphate is a key precursor for the biosynthesis of tyrosol in Saccharomyces cerevisiae. Hence, the flux of D-Erythrose 4-phosphate determined the yield of tyrosol synthesis. In this study, we first obtained an S. cerevisiae strain S19 with a tyrosol yield of 247.66 mg/L by metabolic engineering strategy. To increase the production of D-Erythrose 4-phosphate, highly active phosphoketolase BA-C was obtained by bioinformatics combined with tyrosol yield assay. The key residue sites 183, 217, and 320 were obtained by molecular docking, kinetic simulation, and tyrosol yield verification. After mutation, the highly efficient phosphoketolase BA-C His320Met was obtained, with a 37.32 % increase in enzyme activity. The tyrosol production of strain S26 with BA-C His320Arg increased by 43.05 % than strain S25 with BA-C and increased by 151.19 % compared with the strain S19 without phosphoketolase in a 20 L fermenter. The mining and modification of phosphoketolase will provide strong support for the de novo synthesis of aromatic compounds.
C1 [Song, Na; Xie, Yaoru; Guo, Shuaikang; Zhou, Rong; Shangguan, Lingling; Zhuang, Kun; Zhang, Huiyan; An, Feiran; Zheng, Xueyun; Yao, Lan; Chen, Xiong; Dai, Jun] Hubei Univ Technol, Cooperat Innovat Ctr Ind Fermentat, Natl Ctr Cellular Regulat & Mol Pharmaceut 111, Key Lab Fermentat Engn,Minist Educ & Hubei Prov,Hu, Wuhan 430068, Peoples R China.
   [Xia, Huili] Huanghuai Univ, Coll Biol & Food Engn, Zhumadian 463000, Peoples R China.
   [Zhuang, Kun] Wuhan Polytech Univ, Sch Food Sci & Engn, Wuhan 430023, Peoples R China.
   [Yang, Shihui; Dai, Jun] Hubei Univ, Sch Life Sci, State Key Lab Biocatalysis & Enzyme Engn, Wuhan 430062, Hubei, Peoples R China.
C3 Hubei University of Technology; Huanghuai University; Wuhan Polytechnic
   University; Hubei University
RP Chen, X; Dai, J (corresponding author), Hubei Univ Technol, Sch Life & Hlth Sci, 28 Nanli Rd, Wuhan 430068, Hubei, Peoples R China.
EM cx163_qx@163.com; jundai@hbut.edu.cn
RI Yang, Shihui/AAE-4100-2020
FU National Natural Science Foundations of China [31871789, 41876114]; key
   project of Hubei Provincial Department of Education [T2022011]; Natural
   Science Foundation of Hubei Province [2024AFB803]
FX This work was supported by the National Natural Science Foundations of
   China (Grant Nos. 31871789 and 41876114) , the key project of Hubei
   Provincial Department of Education (T2022011) , the Natural Science
   Foundation of Hubei Province (No. 2024AFB803) .
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NR 64
TC 4
Z9 5
U1 9
U2 49
PU KEAI PUBLISHING LTD
PI BEIJING
PA 16 DONGHUANGCHENGGEN NORTH ST, Building 5, Room 411, BEIJING, DONGCHENG
   DISTRICT 100009, PEOPLES R CHINA
SN 2405-805X
J9 SYN SYST BIOTECHNO
JI Synth. Syst. Biotechnol.
PY 2025
VL 10
IS 1
BP 294
EP 306
DI 10.1016/j.synbio.2024.11.007
PG 13
WC Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology
GA P6M3B
UT WOS:001379021200001
PM 39686978
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Li, JH
   Cui, YY
   Yao, JM
   Guo, CC
   Jiao, MW
AF Li, Junhan
   Cui, Yuying
   Yao, Jinming
   Guo, Congcong
   Jiao, Mingwen
TI Mechanistic insights of Rhodiola crenulata in treating diabetic
   kidney disease via network pharmacology
SO JOURNAL OF MOLECULAR ENDOCRINOLOGY
LA English
DT Article
DE <italic>Rhodiola crenulata</italic>; renal fibrosis; diabetic kidney
   disease; network pharmacology; TGF-beta 1; myofibroblasts
ID EXTRACELLULAR-MATRIX ACCUMULATION; CELL-PROLIFERATION; MESANGIAL CELLS;
   FIBROBLASTS; PATHWAY; TRANSITION; EXPRESSION; PROTEIN
AB Rhodiola crenulata (RC) has been traditionally used for its therapeutic benefits, including alleviating high-altitude sickness, fatigue, and diabetes. Diabetic kidney disease (DKD), a severe complication of diabetes, often leads to progressive renal fibrosis. This study explored the protective effects of RC against kidney fibrosis in DKD rat models, identifying active compounds and their therapeutic targets, with a focus on salidroside (SAL), a key component of RC. After administering RC to DKD rats, network pharmacology analysis identified 22 core components and 141 DKD-related therapeutic targets, with TGFB1 emerging as a primary target in kidney fibrosis. In vivo experiments demonstrated that RC reduced fibrosis markers by decreasing glomerular mesangial expansion, collagen deposition, and myofibroblast proliferation, alongside lowering TGF-beta 1 levels. In vitro analyses revealed that SAL inhibited high glucose-induced fibroblast activation and suppressed TGF-beta 1 expression in proximal renal tubular epithelial cells (PTECs), suggesting its direct role in slowing fibrosis progression. These findings indicate that the antifibrotic effects of RC in DKD may be attributed to SAL's ability to regulate fibroblast activity and suppress TGF-beta 1, highlighting its potential as a therapeutic component for DKD management.
C1 [Li, Junhan; Yao, Jinming; Guo, Congcong] Shandong First Med Univ & Shandong Prov Qianfoshan, Shandong Med Univ 1, Affiliated Hosp 1,Shandong Key Lab Rheumat Dis & T, Shandong Inst Nephrol,Dept Endocrinol & Metabol, Shandong Key Lab Rheumat Dis & Translat Med, Jinan, Shandong, Peoples R China.
   [Cui, Yuying; Yao, Jinming] Shandong Univ Tradit Chinese Med, Jinan, Shandong, Peoples R China.
   [Jiao, Mingwen] Shandong First Med Univ & Shandong Prov Qianfoshan, Affiliated Hosp 1, Dept Gen Surg, Jinan, Shandong, Peoples R China.
C3 Shandong University of Traditional Chinese Medicine
RP Guo, CC (corresponding author), Shandong First Med Univ & Shandong Prov Qianfoshan, Shandong Med Univ 1, Affiliated Hosp 1,Shandong Key Lab Rheumat Dis & T, Shandong Inst Nephrol,Dept Endocrinol & Metabol, Shandong Key Lab Rheumat Dis & Translat Med, Jinan, Shandong, Peoples R China.; Jiao, MW (corresponding author), Shandong First Med Univ & Shandong Prov Qianfoshan, Affiliated Hosp 1, Dept Gen Surg, Jinan, Shandong, Peoples R China.
EM gccqfshospital@163.com; 2018120218@mail.sdu.edu.cn
RI Cui, Yuying/NJS-4430-2025
FU National Natural Science Foundation of China
FX The chemical structures in Table 2 were created with BioRender.com. We
   would like to acknowledge Prof. Jianjun Dong, professor of Shandong
   University, for his guidance on the work.
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NR 66
TC 1
Z9 2
U1 5
U2 7
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA STARLING HOUSE, 1600 BRISTOL PARKWAY N, BRISTOL, ENGLAND
SN 0952-5041
EI 1479-6813
J9 J MOL ENDOCRINOL
JI J. Mol. Endocrinol.
PD JUL 1
PY 2025
VL 75
IS 1
AR e250006
DI 10.1530/JME-25-0006
PG 19
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 6TU9X
UT WOS:001561860900004
PM 40504978
DA 2026-05-27
ER

PT J
AU Wang, S
   Feng, YM
   Zheng, L
   He, PF
   Tan, JY
   Cai, JH
   Wu, MH
   Ye, XX
AF Wang, Shen
   Feng, Yanmin
   Zheng, Lin
   He, Panfeng
   Tan, Jingyi
   Cai, Jinhui
   Wu, Minhua
   Ye, Xiaoxia
TI Rosavin: Research Advances in Extraction and Synthesis, Pharmacological
   Activities and Therapeutic Effects on Diseases of the Characteristic
   Active Ingredients of Rhodiola rosea L.
SO MOLECULES
LA English
DT Review
DE Rhodiola rosea L.; rosavin; extraction and synthesis; pharmacological
   activity; therapeutic effect
ID SALIDROSIDE; COMBINATION; COMPONENTS; MODEL; MICE
AB Rhodiola rosea L. (RRL) is a popular plant in traditional medicine, and Rosavin, a characteristic ingredient of RRL, is considered one of the most important active ingredients in it. In recent years, with deepening research on its pharmacological actions, the clinical application value and demand for Rosavin have been steadily increasing. Various routes for the extraction and all-chemical or biological synthesis of Rosavin have been gradually developed for the large-scale production and broad application of Rosavin. Pharmacological studies have demonstrated that Rosavin has a variety of biological activities, including antioxidant, lipid-lowering, analgesic, antiradiation, antitumor and immunomodulation effects. Rosavin showed significant therapeutic effects on a range of chronic diseases, including neurological, digestive, respiratory and bone-related disorders during in vitro and vivo experiments, demonstrating the great potential of Rosavin as a therapeutic drug for diseases. This paper gives a comprehensive and insightful overview of Rosavin, focusing on its extraction and synthesis, pharmacological activities, progress in disease-treatment research and formulation studies, providing a reference for the production and preparation, further clinical research and applications of Rosavin in the future.
C1 [Wang, Shen; Tan, Jingyi; Cai, Jinhui] Guangdong Med Univ, Sch Pharm, Zhanjiang 524023, Peoples R China.
   [Feng, Yanmin; Zheng, Lin; He, Panfeng] Guangdong Med Univ, Clin Med Coll 1, Zhanjiang 524023, Peoples R China.
   [Wu, Minhua; Ye, Xiaoxia] Guangdong Med Univ, Sch Basic Med, Zhanjiang 524023, Peoples R China.
C3 Guangdong Medical University; Guangdong Medical University; Guangdong
   Medical University
RP Ye, XX (corresponding author), Guangdong Med Univ, Sch Basic Med, Zhanjiang 524023, Peoples R China.
EM wangshen@gdmu.edu.cn; 13533928525@163.com; jacqueline_linlin@163.com;
   13032863621@163.com; 1131043180tjy@gdmu.edu.cn; kikoyd2023@163.com;
   wugdmczp@gdmu.edu.cn; yexx@gdmu.edu.cn
RI ; Zheng, Lin/AIF-3061-2022
OI Minhua, WU/0000-0003-4454-5507; Ye, Xiaoxia/0000-0001-5995-4456; Zheng,
   Lin/0000-0001-5617-5895
FU Guangdong Basic and Applied Basic Research Foundation [2018A030310106];
   National College Students' Innovation and Entrepreneurship Training
   Program [202210571027]; Scientific and Technological Innovation for
   Guangdong College Students [pdjh2023b0236]; Guangdong College Students'
   Innovation and Entrepreneurship Training Program [S202310571061]
FX This research was supported by the Guangdong Basic and Applied Basic
   Research Foundation (number 2018A030310106), National College Students'
   Innovation and Entrepreneurship Training Program (number 202210571027),
   Scientific and Technological Innovation for Guangdong College Students
   (number pdjh2023b0236) and Guangdong College Students' Innovation and
   Entrepreneurship Training Program (number S202310571061).
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NR 71
TC 16
Z9 23
U1 7
U2 50
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD NOV
PY 2023
VL 28
IS 21
AR 7412
DI 10.3390/molecules28217412
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA Y2AZ8
UT WOS:001103359600001
PM 37959831
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Lu, L
   Zhu, JJ
   Zhang, HY
   Li, XP
   Chen, KD
AF Lu, Lu
   Zhu, Jiajie
   Zhang, Haiyan
   Li, Xiaoping
   Chen, Keda
TI Advances in the Pharmacological Intervention of Endothelial Progenitor
   Cells in the Treatment of Ischemic Stroke
SO CEREBROVASCULAR DISEASES
LA English
DT Review
DE Ischemic stroke; Endothelial progenitor cells; Novel drug therapy
ID SALIDROSIDE; DAMAGE
AB Background: Ischemic stroke, a common central nervous system disease that seriously threatens human life and health, is characterized by rapid progress and a high disability fatality rate. Ischemic tissue can produce a large amount of vascular endothelial growth factor (VEGF) and stromal cell-derived factor 1 (SDF-1) to promote the mobilization of endothelial progenitor cells (EPCs). Summary: As newly discovered stem cells, EPCs can promote angiogenesis in ischemic tissue, repair the damaged vascular endothelium, and maintain vascular homeostasis. Thus, EPCs have become a new research hotspot in this field. This review focuses on the mechanism of EPCs and the intervention of various novel drugs, including small molecules and biomolecules, which will promote the capture, proliferation, and differentiation of EPCs. Then, we explore the promotion of vascular health and the prospect of its application in the treatment of cerebral ischemic stroke (CIS). Key Message: It is clinically significant to study the potential of new drug therapy to target EPCs. More effective cytokines, signal pathways, and other drugs should be explored in the future and their specific mechanisms determined. Research should reveal more biological functions of EPCs and achieve their efficient amplification to improve therapy against CIS stroke.
C1 [Lu, Lu; Zhu, Jiajie; Li, Xiaoping; Chen, Keda] Zhejiang Shuren Univ, Shulan Int Med Coll, Hangzhou, Peoples R China.
   [Zhang, Haiyan] Zhejiang Chinese Med Univ, Hangzhou, Peoples R China.
C3 Zhejiang Shuren University; Zhejiang Chinese Medical University
RP Li, XP; Chen, KD (corresponding author), Zhejiang Shuren Univ, Shulan Int Med Coll, Hangzhou, Peoples R China.
EM 1019717619@qq.com; chenkd@zjsru.edu.cn
RI Li, xiaoping/GPX-5591-2022; Chen, Keda/AAK-5804-2021; Zhang,
   Haiyan/HPG-4116-2023
OI Li, xiaoping/0000-0003-0156-0803; zhu, jiajie/0000-0003-3376-726X; Chen,
   Keda/0000-0002-9469-0991; 
FU Zhejiang provincial basic public welfare research program
   [LGF21H200007]; Major horizontal projects of Zhejiang Shuren University
   [202111842040]
FX This study was financially supported by the Zhejiang provincial basic
   public welfare research program (LGF21H200007) and the Major horizontal
   projects of Zhejiang Shuren University (202111842040).
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NR 55
TC 6
Z9 8
U1 0
U2 17
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1015-9770
EI 1421-9786
J9 CEREBROVASC DIS
JI Cerebrovasc. Dis.
PD DEC
PY 2022
VL 51
IS 6
BP 697
EP 705
DI 10.1159/000524414
EA MAY 2022
PG 9
WC Clinical Neurology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Cardiovascular System & Cardiology
GA 8M6YB
UT WOS:000795877800001
PM 35512667
DA 2026-05-27
ER

PT J
AU Yousef, GG
   Grace, MH
   Cheng, DM
   Belolipov, IV
   Raskin, I
   Lila, MA
AF Yousef, Gad G.
   Grace, Mary H.
   Cheng, Diana M.
   Belolipov, Igor V.
   Raskin, Ilya
   Lila, Mary Ann
TI Comparative phytochemical characterization of three Rhodiola
   species
SO PHYTOCHEMISTRY
LA English
DT Article
DE Rhodiola heterodonta; Rhodiola semenovii; Rhodiola rosea; Crassulaceae;
   heterodontoside; phenylethanoid glycosides; cyanogenic glucosides;
   proanthocyanidins; prodelphinidins; EGCG; EGC; HPLC-ESI-MS
ID HIGHLY POLYMERIZED PROCYANIDINS; PROANTHOCYANIDINS; GLYCOSIDES; ROSEA;
   FOODS; TEA; BIOSYNTHESIS; CONSTITUENTS; IONIZATION; KERMERRIEN
AB In comparison to the well-recognized adaptogenic herb Rhodiola rosea, phytochemical constituents of two other Rhodiola species (R. heterodonta and R. semenovii) were elucidated and characterized. Two major phytochemical groups; phenolic and/or cyanogenic glycosides and proanthocyanidins, were isolated and identified in the three species. Chemical similarities among the three species were observed; however, each species displayed differences in phytochemical constituents. R. heterodonta contained a newly detected phenyl-ethanoid glycoside, heterodontoside, in addition to the known compounds tyrosol, viridoside, salidroside, and rhodiocyanoside A. Both R. heterodonta and R. rosea contained phenylethanoid/propanoid. compounds that were not detected in R. semenovii. For R. semenovii, the cyanogenic glucosides rhodiocyanoside A and lotaustralin were detected. Although the three species have proanthocyanidins composed of (-)-epigallocatechin and its 3-O-gallate esters in common, the degree of polymerization greatly differed between them. In contrast to R. heterodonta and R. semenovii, R. rosea has higher molecular weight polymeric proanthocyanidins. This study resulted in the identification and isolation of phytochemical constituents for direct cross-comparison between three Rhodiola species of medicinal and pharmacological value. (c) 2006 Elsevier Ltd. All rights reserved.
C1 Univ Illinois, Dept Nat Resources & Environm Sci, Urbana, IL 61801 USA.
   Tashkent State Univ, Tashkent, Uzbekistan.
   Rutgers State Univ, Cook Coll, Biotech Ctr, New Brunswick, NJ 08901 USA.
C3 University of Illinois System; University of Illinois Urbana-Champaign;
   National University of Uzbekistan; Tashkent State Technical University
   named after Islam Karimov; Rutgers University System; Rutgers University
   New Brunswick
RP Lila, MA (corresponding author), Univ Illinois, Dept Nat Resources & Environm Sci, Urbana, IL 61801 USA.
EM imagemal@uiuc.edu
RI Grace, Mary/AAE-4629-2021
OI Grace, Mary/0000-0002-8536-4211; Lila, Mary Ann/0000-0002-4928-3836;
   Raskin, Ilya/0000-0002-3025-8112
FU FIC NIH HHS [U01 TW006674] Funding Source: Medline
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NR 41
TC 96
Z9 106
U1 1
U2 57
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9422
J9 PHYTOCHEMISTRY
JI Phytochemistry
PD NOV
PY 2006
VL 67
IS 21
BP 2380
EP 2391
DI 10.1016/j.phytochem.2006.07.026
PG 12
WC Biochemistry & Molecular Biology; Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Biochemistry & Molecular Biology; Plant Sciences
GA 104BQ
UT WOS:000241931300009
PM 16956631
DA 2026-05-27
ER

PT J
AU Yao, JF
AF Yao, Jinfu
TI Tiao He Yi Wei Granule, a Traditional Chinese Medicine, against
   Ethanol-Induced Gastric Ulcer in Mice
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID ACUTE LUNG INJURY; IN-VIVO; GASTROPROTECTIVE ACTIVITY; PROTECTIVE
   ACTIVITY; SALIDROSIDE; MECHANISMS; POLYDATIN; APIGENIN; DAMAGE
AB Tiao He Yi Wei granule (DHYW), a traditional Chinese medicine, has been used for the treatment of gastric ulcer in clinical setting. The purpose of the present study was to investigate the possible effect of DHYW and explore the underlying mechanism against ethanol-induced gastric ulcer in mice. The model of ethanol-induced gastric ulcer in mice was induced by ethanol (0.2 mL/kg). Administration of DHYW at the doses of 250, 500 mg/kg body weight prior to the ethanol ingestion could effectively protect the stomach from ulceration. The gastric lesions were significantly ameliorated in the DHYW group compared with that in the model group. Treatment with DHYW markedly decreased the levels of interleukin-6 (IL-6), IL-1 beta, and tumor necrosis factor-alpha (TNF-alpha). In addition, DHYW treatment elevated myeloperoxidase (MPO) level in stomach, increased superoxide dismutase (SOD) activity, and decreased malonaldehyde(MDA) content in serum and stomach compared with those in the model group. DHYW significantly inhibited NF-kappa B pathway expressions in the gastric mucosa ulcer group. Taken together, DHYW exerted a gastroprotective effect against gastric ulceration and the underlying mechanism might be associated with NF-kappa B pathway.
C1 [Yao, Jinfu] Changchun Univ Chinese Med, Changchun 130117, Peoples R China.
C3 Changchun University of Chinese Medicine
RP Yao, JF (corresponding author), Changchun Univ Chinese Med, Changchun 130117, Peoples R China.
EM yaojinfuch@126.com
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NR 29
TC 15
Z9 16
U1 1
U2 17
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2015
VL 2015
AR 647283
DI 10.1155/2015/647283
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA CZ1FW
UT WOS:000366852300001
PM 26779276
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Zhou, YZ
   Lin, Y
   Liu, XH
   Ju, WZ
AF Zhou, Yizhi
   Lin, Ying
   Liu, Xunhong
   Ju, Wenzheng
TI Simultaneous Determination of 12 Index Components and Compatibility
   Changes in Longchai Decoction by Liquid Chromatography-Mass Spectrometry
SO JOURNAL OF CHROMATOGRAPHIC SCIENCE
LA English
DT Article
ID IDENTIFICATION; CONSTITUENTS; METABOLITES; SAPONINS; GINSENG
AB The aim of this study was to explore the traditional decoction theory of Chinese medicine compound prescriptions. To control the quality of Longchai decoction and to analyze the changes of chemical components before and after compatibility, the determination method of 12 index components including salidroside, wogonoside, liquiritin, isoliquiritin, liquiritigenin, quercetin, isoliquiritigenin, isorhamnetin, wogonin, saikosaponin A, saikosaponin D and ursolic acid by liquid chromatography-mass spectrometry (LC-MS) was established. The 12 index components were detected by LC-MS with the Agilent Zorbax SB C18 (3.1 x 100 mm, 3.6 mu m) column, the mobile phase consisted of acetonitrile-0.1% methanoic acid with gradient elution at the flow rate of 0.25 mL min(-1) and the column temperature was maintained at 30 degrees C. All the samples were isolated to baseline. All calibration curves showed good linear regression (r(2) > 0.9978). The average recoveries were between 99.16 and 103.25% of relative standard deviation <2.82% (n = 5). Obtained results indicated that the content of index components was increased in traditional decoction, compared with mixed individual decoctions. This method with good resolution and high precision could be used for the quality control of Longchai decoction.
C1 [Zhou, Yizhi; Lin, Ying; Liu, Xunhong] Nanjing Univ Chinese Med, Pharmaceut Coll, Nanjing 210023, Jiangsu, Peoples R China.
   [Ju, Wenzheng] Nanjing Univ Chinese Med, Clin Med Coll 1, Nanjing 210029, Jiangsu, Peoples R China.
C3 Nanjing University of Chinese Medicine; Nanjing University of Chinese
   Medicine
RP Liu, XH (corresponding author), Nanjing Univ Chinese Med, Pharmaceut Coll, Nanjing 210023, Jiangsu, Peoples R China.
EM liuxunh1959@sohu.com
RI Zhou, Yizhi/KEJ-3463-2024
FU "Science and Technology Foundation Construction Plan" of Jiangsu
   Province [BM2009903]; Priority Academic Program Development of Jiangsu
   Higher Education Institutions [ysxk-2010]
FX This project was supported by "Science and Technology Foundation
   Construction Plan" of Jiangsu Province (No. BM2009903) and a project
   funded by the Priority Academic Program Development of Jiangsu Higher
   Education Institutions (No. ysxk-2010).
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NR 19
TC 4
Z9 5
U1 0
U2 32
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0021-9665
EI 1945-239X
J9 J CHROMATOGR SCI
JI J. Chromatogr. Sci.
PD JAN
PY 2015
VL 53
IS 1
BP 60
EP 65
DI 10.1093/chromsci/bmu015
PG 6
WC Biochemical Research Methods; Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA CE8OA
UT WOS:000352101300009
PM 24714141
DA 2026-05-27
ER

PT J
AU Li, XA
   Jia, JZ
   Li, T
   Zhao, ZF
   Liu, HJ
   Song, N
   Pei, J
AF Li, Xiaoan
   Jia, Jianzhong
   Li, Tao
   Zhao, Zefeng
   Liu, Haijing
   Song, Na
   Pei, Jin
TI Metabolomics analysis of Ligustri Lucidi Fructus at different harvest
   times during the whole growing period based on ultra-high-performance
   liquid chromatography with mass spectrometry
SO JOURNAL OF SEPARATION SCIENCE
LA English
DT Article
DE differential metabolites; Ligustri Lucidi Fructus; multivariate
   statistical analysis
ID BONE-MINERAL DENSITY; IN-VITRO; FERULIC ACID; EXTRACT; ANTIOXIDANT;
   CELLS; POLYSACCHARIDES; BRAN
AB After medicinal market research, it was found that the harvest time of Ligustri Lucidi Fructus (LLF) was chaotic in practice. In order to determine the optimal harvest period of LLF to ensure its pharmacological activity, metabolomics analysis of LLF at different harvest times based on ultra-high-performance liquid chromatography-triple quadrupole-(linear ion trap)-tandem mass spectrometry was established. In this study, 166 differential metabolites (DMs) in 448 metabolites at different harvest times were screened out based on variable importance in projection value, and among them, 94 DMs with regular trends of change in relative content (59 increased and 35 decreased with the growth period) were chosen to further research. The result of the multivariate statistical analysis showed that November was the optimal harvest period of LLF. Additionally, 10-hydroxyligustroside, oleoside 11-methyl ester, and salidroside were screened out to be used as the evaluation indicators of immature LLF, while specnuezhenide, nuezhenoside G13, and neonuezhenide were the evaluation indicators of mature LLF. This study provides fundamental insight for metabolite identification and proposes the best harvest period of LLF to avoid confusion in the medicinal market.
C1 [Li, Xiaoan; Pei, Jin] Chengdu Univ Tradit Chinese Med, Sch Pharm, Natl Key Lab Breeding Base Systemat Res Dev & Util, Chengdu, Peoples R China.
   [Li, Xiaoan] Ankang Inspect & Testing Ctr Food & Drug, Ankang, Peoples R China.
   [Jia, Jianzhong; Li, Tao; Liu, Haijing] Shaanxi Inst Food & Drug Control, Shaanxi Key Lab Food & Drug Safety Monitoring, Xian, Peoples R China.
   [Zhao, Zefeng] Shaanxi Univ Chinese Med, Xianyang, Peoples R China.
   [Song, Na] Xian Cent Hosp, Xian, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Shaanxi University
   of Chinese Medicine
RP Pei, J (corresponding author), Chengdu Univ Tradit Chinese Med, Sch Pharm, Natl Key Lab Breeding Base Systemat Res Dev & Util, Chengdu, Peoples R China.; Jia, JZ (corresponding author), Shaanxi Inst Food & Drug Control, Shaanxi Key Lab Food & Drug Safety Monitoring, Xian, Peoples R China.
EM jiajianzhong126@hotmail.com; peixjin@163.com
OI Jia, Jianzhong/0000-0003-3260-4899
FU We sincerely thank the Innovation Team and Talents Cultivation Program
   of the National Administration of Traditional Chinese Medicine. (No:
   ZYYCXTD-D-202209). [ZYYCXTD-D-202209]; Innovation Team and Talents
   Cultivation Program of the National Administration of Traditional
   Chinese Medicine
FX We sincerely thank the Innovation Team and Talents Cultivation Program
   of the National Administration of Traditional Chinese Medicine. (No:
   ZYYCXTD-D-202209).
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NR 52
TC 7
Z9 7
U1 1
U2 21
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 1615-9306
EI 1615-9314
J9 J SEP SCI
JI J. Sep. Sci.
PD NOV
PY 2023
VL 46
IS 22
DI 10.1002/jssc.202300196
EA OCT 2023
PG 15
WC Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA AZ3Y0
UT WOS:001077105400001
PM 37806751
DA 2026-05-27
ER

PT J
AU Nawrot, J
   Gornowicz-Porowska, J
   Budzianowski, J
   Nowak, G
   Schroeder, G
   Kurczewska, J
AF Nawrot, Joanna
   Gornowicz-Porowska, Justyna
   Budzianowski, Jaromir
   Nowak, Gerard
   Schroeder, Grzegorz
   Kurczewska, Joanna
TI Medicinal Herbs in the Relief of Neurological, Cardiovascular, and
   Respiratory Symptoms after COVID-19 Infection A Literature Review
SO CELLS
LA English
DT Review
DE COVID-19; complications; viral infections; phytotherapy; medicinal herbs
ID DOUBLE-BLIND; GINKGO-BILOBA; KAVA-EXTRACT; CONTROLLED TRIAL; MIXED
   ANXIETY; ESSENTIAL OIL; PLACEBO; INHIBITION; MODULATION; MECHANISMS
AB COVID-19 infection causes complications, even in people who have had a mild course of the disease. The most dangerous seem to be neurological ailments: anxiety, depression, mixed anxiety-depressive (MAD) syndromes, and irreversible dementia. These conditions can negatively affect the respiratory system, circulatory system, and heart functioning. We believe that phytotherapy can be helpful in all of these conditions. Clinical trials confirm this possibility. The work presents plant materials (Valerian officinalis, Melissa officinalis, Passiflora incarnata, Piper methysticum, Humulus lupulus, Ballota nigra, Hypericum perforatum, Rhodiola rosea, Lavandula officinalis, Paullinia cupana, Ginkgo biloba, Murraya koenigii, Crataegus monogyna and oxyacantha, Hedera helix, Polygala senega, Pelargonium sidoides, Lichen islandicus, Plantago lanceolata) and their dominant compounds (valeranon, valtrate, apigenin, citronellal, isovitexin, isoorientin, methysticin, humulone, farnesene, acteoside, hypericin, hyperforin, biapigenin, rosavidin, salidroside, linalool acetate, linalool, caffeine, ginkgolide, bilobalide, mihanimbine, epicatechin, hederacoside C,alpha-hederine, presegenin, umckalin, 6,7,8-trixydroxybenzopyranone disulfate, fumaroprotocetric acid, protolichesteric acid, aucubin, acteoside) responsible for their activity. It also shows the possibility of reducing post-COVID-19 neurological, respiratory, and cardiovascular complications, which can affect the functioning of the nervous system.
C1 [Nawrot, Joanna; Gornowicz-Porowska, Justyna; Budzianowski, Jaromir; Nowak, Gerard] Poznan Univ Med Sci, Dept & Div Pract Cosmetol & Skin Dis Prophylaxis, Rokietnicka 3, PL-60806 Poznan, Poland.
   [Schroeder, Grzegorz; Kurczewska, Joanna] Adam Mickiewicz Univ, Fac Chem, Uniwersytetu 5,Poznanskiego 8, PL-61614 Poznan, Poland.
C3 Poznan University of Medical Sciences; Adam Mickiewicz University
RP Nawrot, J (corresponding author), Poznan Univ Med Sci, Dept & Div Pract Cosmetol & Skin Dis Prophylaxis, Rokietnicka 3, PL-60806 Poznan, Poland.
EM joannac@ump.edu.pl; justyna.gornowicz-porowska@ump.edu.pl;
   jbudzian@ump.edu.pl; gnowak.gerard@gmail.com; schroede@amu.edu.pl;
   asiaw@amu.edu.pl
RI Kurczewska, Joanna/C-6259-2014; Budzianowski, Jaromir/GRX-4015-2022
OI Kurczewska, Joanna/0000-0002-9046-3230; Nawrot,
   Joanna/0000-0002-1904-5503; Budzianowski, Jaromir/0000-0001-6931-011X;
   Schroeder, Grzegorz/0000-0002-6626-9542
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NR 131
TC 31
Z9 40
U1 2
U2 46
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD JUN
PY 2022
VL 11
IS 12
AR 1897
DI 10.3390/cells11121897
PG 25
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 2K2QV
UT WOS:000816188100001
PM 35741026
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Silva, EK
   Saldana, MDA
AF Silva, Eric Keven
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TI High-intensity ultrasound-assisted recovery of cinnamyl alcohol
   glycosides from Rhodiola rosea roots: Effect of probe diameter on
   the ultrasound energy performance for the extraction of bioactive
   compounds
SO FOOD AND BIOPRODUCTS PROCESSING
LA English
DT Article
DE Rosavin; Rosin; Acoustic cavitation; Ultrasound energy efficiency;
   Antioxidant activity; Total phenolic content; Ferric reducing ability of
   plasma
ID PHENOLIC-COMPOUNDS; ANTIOXIDANT; L.; POWER; OPTIMIZATION; SALIDROSIDE;
   PEEL
AB High-intensity ultrasound (HIUS) energy performance was evaluated using different probe diameters (10 and 20 mm) and specific energies (0.5, 1.0, 3.0, and 5.0 kJ/g) to recover rosavin and rosin from Rhodiola rosea roots. Also, intensified HIUS process conditions (5, 10, 15, and 20 kJ/g) assisted by a cold bath were studied. HIUS energy performance depended on probe diameter at the same nominal power. The larger diameter probe was more energy-efficient, however, the smaller diameter had more ultrasonic intensity (W/cm(2)). The diameters evaluated did not influence the extraction yields, however, the increase of the HIUS specific energy from 0.5 to 5.0 kJ/g increased phenolic compounds content, antioxidant activities, and rosavin and rosin yields. The HIUS process intensification confirmed that the main extraction mechanism was diffusion and the role of the ultrasound was to increase the diffusion coefficients by increasing the turbulence in the liquid medium due to acoustic cavitation. (C) 2020 Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.
C1 [Silva, Eric Keven; Saldana, Marleny D. A.] Univ Alberta, Dept Agr Food & Nutr Sci, Edmonton, AB T6G 2P5, Canada.
C3 University of Alberta
RP Saldana, MDA (corresponding author), 3-18A Agr Forestry Ctr,115 St 90 Ave, Edmonton, AB T6G 2P5, Canada.
EM engerickeven@gmail.com; marleny.saldana@ualberta.ca
RI Silva, Eric Keven/M-9379-2014
OI Silva, Eric Keven/0000-0002-7623-8539
FU Natural Sciences and Engineering Research Council of Canada (NSERC)
   [04371-2019]; 2017-2018 McCalla Professorship award; FAPESP
   [2018/14550-6]; Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
   (FAPESP) [18/14550-6] Funding Source: FAPESP
FX We would like to acknowledge the Natural Sciences and Engineering
   Research Council of Canada (NSERC, #04371-2019) for funding this
   research. Marleny DA. Saldafia thanks the 2017-2018 McCalla
   Professorship award. Eric Keven Silva thanks FAPESP (2018/14550-6) for
   his postdoctoral assistantship at University of Alberta. We also thank
   St. Francis Herb Farm Inc. for providing the Rhodiola sample.
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NR 45
TC 40
Z9 41
U1 1
U2 19
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0960-3085
EI 1744-3571
J9 FOOD BIOPROD PROCESS
JI Food Bioprod. Process.
PD JUL
PY 2020
VL 122
BP 245
EP 253
DI 10.1016/j.fbp.2020.05.012
PG 9
WC Biotechnology & Applied Microbiology; Engineering, Chemical; Food
   Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Engineering; Food Science &
   Technology
GA MZ0CC
UT WOS:000558789900009
DA 2026-05-27
ER

PT J
AU Hadjmohammadi, MR
   Kiasari, ZM
   Nazari, SSSJ
AF Hadjmohammadi, M. R.
   Kiasari, Z. Mousavi
   Nazari, S. S. S. J.
TI Separation of some phenolic acids in micellar liquid chromatography
   using design of experiment-response surface methodology
SO JOURNAL OF ANALYTICAL CHEMISTRY
LA English
DT Article
DE micellar liquid chromatography; response surface methodology; central
   composite design; phenolic acid
ID SIMULTANEOUS-OPTIMIZATION; RHODIOLA-ROSEA; RAT PLASMA; PERFORMANCE;
   SELECTIVITY; IONIZATION; SALIDROSIDE; FLAVONOIDS; RESOLUTION; MIXTURE
AB Derringer's desirability function combined with face-centered cube central composite design was used to map the chromatographic response surface for simultaneous optimization of resolution and analysis time of four phenolic acids (vanilic, cafeic, para-coumaric and ferulic) in micellar liquid chromatography. The factors studied were the concentration of sodium dodecyl sulfate (SDS), volume percentage of propanol (PrOH), and acetic acid (AcOH) in mobile phase. The chromatographic response functions (CRFs) were formed using two sigmoidal desirability functions. The quality of the obtained chromatograms in each experiment was calculated using CRF, and the model was built by the use of multiple linear regression (MLR) to correlate the obtained CRFs with the experimental factors and their interactions. The developed MLR model showed good descriptive and predictive ability (R (2) = 0.9569 and F = 24.45). The optimum mobile phase composition was found to be [SDS] = 20 mM, 1.0% (v/v) PrOH and 2.0% (v/v) AcOH, which provided good resolution and analysis time for the separation of target phenolic acids. The efficiency of prediction of polynomial model was confirmed by performing the experiment under the predicted optimal conditions.
C1 [Hadjmohammadi, M. R.; Kiasari, Z. Mousavi; Nazari, S. S. S. J.] Univ Mazandaran, Dept Chem, POB 47516-95447,Niroo Havaii St, Babol Sar, Iran.
C3 University of Mazandaran
RP Nazari, SSSJ (corresponding author), Univ Mazandaran, Dept Chem, POB 47516-95447,Niroo Havaii St, Babol Sar, Iran.
EM s.nazari@umz.ac.ir
RI /AAM-4079-2021
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NR 39
TC 5
Z9 5
U1 0
U2 14
PU PLEIADES PUBLISHING INC
PI MOSCOW
PA PLEIADES PUBLISHING INC, MOSCOW, 00000, RUSSIA
SN 1061-9348
EI 1608-3199
J9 J ANAL CHEM+
JI J. Anal. Chem.
PD JUN
PY 2016
VL 71
IS 6
BP 610
EP 616
DI 10.1134/S106193481606006X
PG 7
WC Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA DO2DS
UT WOS:000377590500012
DA 2026-05-27
ER

PT J
AU Rodrigues, CF
   Cernáková, L
AF Rodrigues, Celia F.
   Cernakova, Lucia
TI Farnesol and Tyrosol: Secondary Metabolites with a Crucial
   quorum-sensing Role in Candida Biofilm Development
SO GENES
LA English
DT Review
DE quorum-sensing molecules; farnesol; tyrosol; biofilm
ID VIRGIN OLIVE OIL; BIOSYNTHESIS PATHWAY; MOLECULE FARNESOL; INDUCED
   APOPTOSIS; OXIDATIVE-STRESS; ALBICANS; SECRETION; YEAST; COMMUNICATION;
   SALIDROSIDE
AB When living in biological and interactive communities, microorganisms use quorum-sensing mechanisms for their communication. According to cell density, bacteria and fungi can produce signaling molecules (e.g., secondary metabolites), which participate, for example, in the regulation of gene expression and coordination of collective behavior in their natural niche. The existence of these secondary metabolites plays a main role in competence, colonization of host tissues and surfaces, morphogenesis, and biofilm development. Therefore, for the design of new antibacterials or antifungals and understanding on how these mechanisms occur, to inhibit the secretion of quorum-sensing (e.g., farnesol and tyrosol) molecules leading the progress of microbial infections seems to be an interesting option. In yeasts, farnesol has a main role in the morphological transition, inhibiting hyphae production in a concentration-dependent manner, while tyrosol has a contrary function, stimulating transition from spherical cells to germ tube form. It is beyond doubt that secretion of both molecules by fungi has not been fully described, but specific meaning for their existence has been found. This brief review summarizes the important function of these two compounds as signaling chemicals participating mainly in Candida morphogenesis and regulatory mechanisms.
C1 [Rodrigues, Celia F.] Univ Porto, LEPABE Lab Proc Engn Environm Biotechnol & Energy, Fac Engn, Rua Dr Roberto Frias, P-4200465 Porto, Portugal.
   [Cernakova, Lucia] Comenius Univ, Dept Microbiol & Virol, Fac Nat Sci, Ilkovicova 6, Bratislava 84215, Slovakia.
C3 Universidade do Porto; Comenius University Bratislava
RP Cernáková, L (corresponding author), Comenius Univ, Dept Microbiol & Virol, Fac Nat Sci, Ilkovicova 6, Bratislava 84215, Slovakia.
EM c.fortunae@gmail.com; lucia.cernakova@uniba.sk
RI Rodrigues, Celia F/N-2619-2013
OI Rodrigues, Celia F/0000-0001-8633-2230; Černáková,
   Lucia/0000-0001-5300-3254
FU Slovak Research and Development Agency [APVV-15-0347]; Grant VEGA -
   Ministry of Education, Science, Research, and Sport of the Slovak
   Republic [1/0537/19]; Project-Laboratory of Process Engineering,
   Environment, Biotechnology and Energy (LEPABE) - national funds through
   FCT/MCTES (PIDDAC) [UID/EQU/00511/2020]
FX This work and Article Processing Charge (APC) were funded by the Slovak
   Research and Development Agency under the contract No. (APVV-15-0347)
   and by the Grant VEGA (1/0537/19) supported by the Ministry of
   Education, Science, Research, and Sport of the Slovak Republic. C.F.R.
   would like to acknowledge the UID/EQU/00511/2020 Project-Laboratory of
   Process Engineering, Environment, Biotechnology and Energy (LEPABE),
   financed by national funds through FCT/MCTES (PIDDAC).
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NR 77
TC 94
Z9 107
U1 6
U2 81
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4425
J9 GENES-BASEL
JI Genes
PD APR
PY 2020
VL 11
IS 4
AR 444
DI 10.3390/genes11040444
PG 15
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA LT7CM
UT WOS:000537224600047
PM 32325685
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Aydogan, F
   Anouar, E
   Aygün, M
   Yusufoglu, H
   Karaalp, C
   Bedir, E
AF Aydogan, Fadime
   Anouar, El Hassane
   Aygun, Muhittin
   Yusufoglu, Hasan
   Karaalp, Canan
   Bedir, Erdal
TI An unprecedented diterpene with three new neoclerodanes from Teucrium
   sandrasicum O. Schwarz
SO JOURNAL OF MOLECULAR STRUCTURE
LA English
DT Article
DE Teucrium sandrasicum; Phenylethanoids; Iridoids; neo clerodanes;
   Cytotoxicity
ID ABSOLUTE STEREOCHEMISTRY; NEO-CLERODANES; GLYCOSIDES; C-12
AB From the polar fractions of Teucrium sandrasicum O. Schwarz. roots, eleven known glycosides were isolated including three iridoids [8O-acetyl harpagide (1), harpagide (2) and teuhircoside (3)], a flavanone [hesperidin (4)], an acetophenone [androsin (5)] and six phenylethanoids [salidroside (6), leonoside E (7), isoacteoside (8), leonoside B (9), sideritiside A (10), isolavandulifolioside (11)]. In addition, a known [teusandrin A (16)] and four new neoclerodane diterpenoids [isoteusandrin B (12), teusandrin H (13), teusandrin I (14) and teusandrin J (15)] were isolated from the non-polar fraction of T. sandrasicum aerial parts. The structures were elucidated by spectroscopic analysis (1D-, 2D NMR, HR-TOFMS, and IR) and absolute configurations were determined by ECD analysis with TD-DFT at SCRF-B3LYP/6-31 + G (d,p) level of theory studies, and the structures of compounds 12 and 15 were confirmed by X-ray crystallography. Teusandrin H (13) was determined to be a rearranged diterpene formed via cleavage of the ring B of the neoclerodane skeleton. All diterpenes were tested for their cytotoxic activities using MTT assay, and none showed cytotoxicity versus cancer (DU-145 and HeLa) or normal (MRC-5) cell lines at 50 mu M and lower concentrations. (C) 2021 Elsevier B.V. All rights reserved.
C1 [Aydogan, Fadime; Karaalp, Canan] Ege Univ, Dept Pharmaceut Bot, Fac Pharm, TR-35040 Izmir, Turkey.
   [Anouar, El Hassane] Prince Sattam Bin Abdulaziz Univ, Dept Chem, Coll Sci & Humanities Al Kharj, Al Kharj 11942, Saudi Arabia.
   [Aygun, Muhittin] Dokuz Eylul Univ, Dept Phys, Fac Sci, TR-35160 Izmir, Turkey.
   [Yusufoglu, Hasan] Prince Sattam Bin Abdulaziz Univ, Dept Pharmacognosy, Coll Pharm, Al Kharj 11942, Saudi Arabia.
   [Bedir, Erdal] Izmir Inst Technol, Dept Bioengn, Fac Engn, TR-35430 Izmir, Turkey.
C3 Ege University; Prince Sattam Bin Abdulaziz University; Dokuz Eylul
   University; Prince Sattam Bin Abdulaziz University; Izmir Institute of
   Technology
RP Bedir, E (corresponding author), Izmir Inst Technol, Dept Bioengn, Fac Engn, TR-35430 Izmir, Turkey.
EM erdalbedir@iyte.edu.tr
RI AYDOĞAN, Fadime/ABM-8891-2022; Aygün, Muhittin/P-3605-2019; Anouar, El
   Hassane/H-5088-2017; yusufoglu, hasan/V-7829-2017; karaalp,
   canan/JQV-8163-2023; /ABI-3895-2020
OI AYDOĞAN, Fadime/0000-0001-7810-3067; Aygün,
   Muhittin/0000-0001-9670-9062; Anouar, El Hassane/0000-0001-9240-7163; 
FU Ege University Scientific Research Project [18-ECZ-013]; Dokuz Eylul
   University [2010.KB.FEN.13]
FX This project was supported by Ege University Scientific Research
   Project-18-ECZ-013. Special thanks to Prof. Dr. Petek Ballar
   Kirmizibayrak and Sinem Yilmaz for assisting bioactivity studies (Ege
   University, Faculty of Pharmacy), and A. Anzarulhaque for running NMR
   experiments (Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi
   Arabia). The authors also acknowledge Dokuz Eylul University for the use
   of the Oxford Rigaku Xcalibur Eos Diffractometer (purchased under
   University Research Grant No: 2010.KB.FEN.13).
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NR 51
TC 7
Z9 7
U1 1
U2 35
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0022-2860
EI 1872-8014
J9 J MOL STRUCT
JI J. Mol. Struct.
PD MAY 5
PY 2021
VL 1231
AR 129919
DI 10.1016/j.molstruc.2021.129919
EA JAN 2021
PG 12
WC Chemistry, Physical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA QL7QB
UT WOS:000621276500011
OA Green Submitted
DA 2026-05-27
ER

PT J
AU Mirmazloum, I
   Forgáes, I
   Zok, A
   Pedryc, A
   György, Z
AF Mirmazloum, Iman
   Forgaes, Istvan
   Zok, Aniko
   Pedryc, Andrzej
   Gyoergy, Zsuzsanna
TI TRANSGENIC CALLUS CULTURE ESTABLISHMENT, A TOOL FOR METABOLIC
   ENGINEERING OF Rhodiola rosea L.
SO ACTA SCIENTIARUM POLONORUM-HORTORUM CULTUS
LA English
DT Article
DE roseroot; transformation; transgenic callus culture; A. tumefaciens;
   nptII; GUS
ID AGROBACTERIUM-TUMEFACIENS; SALIDROSIDE BIOSYNTHESIS; MEDIATED
   TRANSFORMATION; T-DNA; OVEREXPRESSION; REGENERATION; PLANTS
AB Agrobacterium tumefaciens EHA101 (pTd33) strain carrying uidA (GUS) reporter gene was used in model experiments on roseroot callus transformation. The T-DNA of pTd33 binary vector plasmid harbors nptII gene conferring resistance to kanamycin, and a uidA reporter gene, encodes the beta-glucuronidase enzyme. Roseroot seeds were sterilized and germinated on half strength MS media of which 70% germinated without any pretreatment. Calli were obtained from leaf segments of the in vitro grown seedlings. Calli was grown on solid MS medium supplemented with 1 mg l(-1) NAA and 0.5 mg l(-1) BAP. Different types of calli were obtained of which the green and compact type was chosen for transformation experiments. After co-cultivation with agrobacteria, calli were transferred to the same medium supplemented with 20 mg l(-1) kanamycin, 200 mg l(-1) (c)arbenicillin and 300 mg l(-1) claforan with antioxidants (Polyclar and DTE) for selection. GUS test using a titron buffer was applied for monitoring the transformation of the calli. DNAs of 20 individual samples was extracted and subjected for PCR analysis proved the stable transformation in all of the taken samples by amplifying the nptII gene
C1 [Mirmazloum, Iman; Forgaes, Istvan; Zok, Aniko; Pedryc, Andrzej; Gyoergy, Zsuzsanna] Corvinus Univ Budapest, H-1518 Budapest, Hungary.
C3 Corvinus University Budapest
RP Mirmazloum, I (corresponding author), Corvinus Univ Budapest, Dept Genet & Plant Breeding, POB 53, H-1518 Budapest, Hungary.
EM imanmedica@gmail.corn
RI Mirmazloum, Iman/AAJ-5673-2020; György, Zsuzsanna/L-7105-2016
OI Mirmazloum, Iman/0000-0002-1461-0382; György,
   Zsuzsanna/0000-0002-7803-5487
FU OTKA [PD83728, TAMOP-4.2.1/B-09/1/KMR-2010-0005,
   TAMOP-4.2.2/B-10/1-2010-0023]
FX The research was supported by OTKA (PD83728.),
   TAMOP-4.2.1/B-09/1/KMR-2010-0005 and TAMOP-4.2.2/B-10/1-2010-0023. The
   authors are thankful to Dr. Peter Radacsi for photography assistance and
   Mrs. Zahra Sadeghi for helping in sub-culturing the calluses.
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NR 37
TC 6
Z9 6
U1 3
U2 18
PU UNIV LIFE SCIENCES LUBLIN
PI LUBLIN
PA AKADEMICKA 15, LUBLIN, POLAND
SN 1644-0692
EI 2545-1405
J9 ACTA SCI POL-HORTORU
JI Acta Sci. Pol.-Hortorum Cultus
PY 2014
VL 13
IS 4
BP 95
EP 106
PG 12
WC Horticulture
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture
GA AX4IN
UT WOS:000346896700009
DA 2026-05-27
ER

PT J
AU Tulsawani, R
   Meena, DK
   Shukla, H
   Sharma, P
   Meena, RN
   Gupta, V
   Kumar, R
   Divekar, HM
   Sawhney, RC
AF Tulsawani, Rajkumar
   Meena, Dharmendra Kumar
   Shukla, Hem
   Sharma, Priyanka
   Meena, Ram Niwas
   Gupta, Vanita
   Kumar, Ratan
   Divekar, Harish Madan
   Sawhney, Ramesh Chand
TI Ninety days of repeated gavage administration of Rhodiola imbricata
   extract in rats
SO JOURNAL OF APPLIED TOXICOLOGY
LA English
DT Article
DE Rhodiola; safety assessment; adaptogen; sub-chronic; toxicity
ID AQUEOUS EXTRACT; DOUBLE-BLIND; ROSEA; STRESS; L.; SACHALINENSIS;
   CONSTITUENTS; SALIDROSIDE; PERFORMANCE; FATIGUE
AB Rhodiola imbricata is a high-altitude plant, possesses adaptogenic, immunomodulatory, anti-oxidant and cytoprotective activity, and is widely used in traditional medicine. The present study was designed to ascertain the safety of aqueous extract of R. imbricata root when administered by gavage to rats for 90days. Four groups of animals, each consisting of 15 males and 15 females, were administered 0, 100, 250 or 500mgkg1 extract, in a single dose per day. The experimental rats when administered 100mgkg1 of extract did not show any significant change in their body weight gain, organ/body weight ratio, or histological, hematological and biochemical variables studied. However, at higher doses of 250 and 500mgkg1 extract, an increase in the body weight of rats of both the sexes was apparent without any change in their organ/body weight ratio. Furthermore, a noteworthy increase in plasma glucose and protein levels was recorded at both the higher doses, which were restored to normal after a 2-week withdrawal of treatment. Based on the findings of this study, the no observed effect level was 100mgkg1 body weight per day of aqueous root extract of R. imbricata in rats administered subchronically. Copyright (c) 2011 John Wiley & Sons, Ltd.
C1 [Tulsawani, Rajkumar; Meena, Dharmendra Kumar; Shukla, Hem; Sharma, Priyanka; Meena, Ram Niwas; Gupta, Vanita; Kumar, Ratan; Divekar, Harish Madan; Sawhney, Ramesh Chand] Def Inst Physiol & Allied Sci, Delhi 110054, India.
C3 Defence Research & Development Organisation (DRDO); Defence Institute of
   Physiology & Allied Sciences (DIPAS)
RP Tulsawani, R (corresponding author), Def Inst Physiol & Allied Sci, Lucknow Rd, Delhi 110054, India.
EM rktulsawani@yahoo.com
RI Tulsawani, Rajkumar/AAF-2017-2019; Meena, D.K/KVZ-3197-2024
OI Meena, D.K/0000-0003-3764-6617
FU Defence Research and Development Organisation, Ministry of Defence,
   India
FX Authors are thankful to the Director, DIPAS, and Dr Kshipra Misra, Head
   of the Department for their constant support for this study. This work
   was supported by the Defence Research and Development Organisation,
   Ministry of Defence, India.
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J9 J APPL TOXICOL
JI J. Appl. Toxicol.
PD MAY
PY 2013
VL 33
IS 5
BP 350
EP 356
DI 10.1002/jat.1739
PG 7
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA 113WC
UT WOS:000316699100002
PM 21938734
DA 2026-05-27
ER

PT J
AU Lee, HY
   Jeon, Y
   Kim, YK
   Jang, JY
   Cho, YS
   Bhak, J
   Cho, KH
AF Lee, Hwang-Yeol
   Jeon, Yeonsu
   Kim, Yeon Kyung
   Jang, Jae Young
   Cho, Yun Sung
   Bhak, Jong
   Cho, Kwang-Hyun
TI Identifying molecular targets for reverse aging using integrated network
   analysis of transcriptomic and epigenomic changes during aging
SO SCIENTIFIC REPORTS
LA English
DT Article
ID DNA METHYLATION; GENE-EXPRESSION; LIFE-SPAN; AGE PREDICTION; SIGNAL
   FLOW; MOUSE MODEL; STEM-CELLS; SALIDROSIDE; BLOOD; SENESCENCE
AB Aging is associated with widespread physiological changes, including skeletal muscle weakening, neuron system degeneration, hair loss, and skin wrinkling. Previous studies have identified numerous molecular biomarkers involved in these changes, but their regulatory mechanisms and functional repercussions remain elusive. In this study, we conducted next-generation sequencing of DNA methylation and RNA sequencing of blood samples from 51 healthy adults between 20 and 74 years of age and identified aging-related epigenetic and transcriptomic biomarkers. We also identified candidate molecular targets that can reversely regulate the transcriptomic biomarkers of aging by reconstructing a gene regulatory network model and performing signal flow analysis. For validation, we screened public experimental data including gene expression profiles in response to thousands of chemical perturbagens. Despite insufficient data on the binding targets of perturbagens and their modes of action, curcumin, which reversely regulated the biomarkers in the experimental dataset, was found to bind and inhibit JUN, which was identified as a candidate target via signal flow analysis. Collectively, our results demonstrate the utility of a network model for integrative analysis of omics data, which can help elucidate inter-omics regulatory mechanisms and develop therapeutic strategies against aging.
C1 [Lee, Hwang-Yeol; Cho, Kwang-Hyun] Korea Adv Inst Sci & Technol, Dept Bio & Brain Engn, Daejeon 34141, South Korea.
   [Lee, Hwang-Yeol; Cho, Yun Sung; Bhak, Jong] Clinom Inc, Genome Res Inst, Ulsan 44919, South Korea.
   [Jeon, Yeonsu; Kim, Yeon Kyung; Jang, Jae Young; Bhak, Jong] Ulsan Natl Inst Sci & Technol, Coll Informat & Biotechnol, Dept Biomed Engn, Ulsan 44919, South Korea.
   [Jeon, Yeonsu; Kim, Yeon Kyung; Jang, Jae Young; Bhak, Jong] Ulsan Natl Inst Sci & Technol, Korea Genom Ctr KOGIC, Ulsan 44919, South Korea.
   [Bhak, Jong] Genome Res Fdn, Personal Genom Inst, Osong 28160, South Korea.
C3 Korea Advanced Institute of Science & Technology (KAIST); Ulsan National
   Institute of Science & Technology (UNIST); Ulsan National Institute of
   Science & Technology (UNIST)
RP Cho, KH (corresponding author), Korea Adv Inst Sci & Technol, Dept Bio & Brain Engn, Daejeon 34141, South Korea.; Bhak, J (corresponding author), Clinom Inc, Genome Res Inst, Ulsan 44919, South Korea.; Bhak, J (corresponding author), Ulsan Natl Inst Sci & Technol, Coll Informat & Biotechnol, Dept Biomed Engn, Ulsan 44919, South Korea.; Bhak, J (corresponding author), Ulsan Natl Inst Sci & Technol, Korea Genom Ctr KOGIC, Ulsan 44919, South Korea.; Bhak, J (corresponding author), Genome Res Fdn, Personal Genom Inst, Osong 28160, South Korea.
EM jongbhak@genomics.org; ckh@kaist.ac.kr
RI Bhak, Jong/ONJ-2646-2025; Lee, Hwang-Yeol/HHS-2673-2022; Jang,
   Jae/AAN-1508-2020; Cho, Kwang-Hyun/C-1684-2011
OI Bhak, Jong/0000-0002-4228-1299; 
FU National Research Foundation of Korea (NRF) - Korean Government the
   Ministry of Science and ICT [2020R1A2B5B03094920]; KAIST Grand Challenge
   30 Project; Electronics and Telecommunications Research Institute (ETRI)
   - Korean government [21ZS1100]; Leading Business for Happy Living for
   Ulsan and Miryang - City Research Fund and Miryang City Research Fund
   [2.160475.01, 2.170010.01, 2.180016.01]; Ulsan City Research Fund of
   Ulsan National Institute of Science & Technology (UNIST) [1.200047.01];
   U-K Brand Research Fund of UNIST [1.200108.01]; BioBank of Ulsan
   University Hospital [60SA2016001-001, 60SA2016001-003]; Leading Business
   for Happy Living for Ulsan and Miryang project (Genome-based Biomedical
   Industry Promotion Business)
FX This work was supported by grants from the National Research Foundation
   of Korea (NRF) funded by the Korean Government the Ministry of Science
   and ICT (Grant No. 2020R1A2B5B03094920), the KAIST Grand Challenge 30
   Project, and the Electronics and Telecommunications Research Institute
   (ETRI) funded by the Korean government (Grant No. 21ZS1100; Core
   Technology Research for Self-Improving Integrated Artificial
   Intelligence System). This work was also supported by the Leading
   Business for Happy Living for Ulsan and Miryang (Genome-based Biomedical
   Industry Promotion Business) funded by the Ulsan City Research Fund and
   Miryang City Research Fund (Grant Nos. 2.160475.01, 2.170010.01, and
   2.180016.01); the Research Project funded by the Ulsan City Research
   Fund (Grant No. 1.200047.01) of Ulsan National Institute of Science &
   Technology (UNIST); and the U-K Brand Research Fund (GRANT NO.
   1.200108.01) of UNIST. Human-derived materials used in this study were
   obtained from the BioBank of Ulsan University Hospital (60SA2016001-001
   and 60SA2016001-003). We appreciate all participants and Ulsan as well
   as Miryang citizens who supported the Leading Business for Happy Living
   for Ulsan and Miryang project (Genome-based Biomedical Industry
   Promotion Business).
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NR 107
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U1 0
U2 15
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUN 10
PY 2021
VL 11
IS 1
AR 12317
DI 10.1038/s41598-021-91811-1
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA SV4JC
UT WOS:000663785600067
PM 34112891
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Ma, CH
   Long, HY
   Zhu, WN
   Liu, Z
   Ruan, J
   Zhang, YJ
   Wang, YR
AF Ma Chunhua
   Long Hongyan
   Zhu Weina
   Liu Zheng
   Ruan Jie
   Zhang Yajie
   Wang Yarui
TI Betulin inhibited cigarette smoke-induced COPD in mice
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Betulin; COPD; ROCK/NF-kappa B
ID ACUTE LUNG INJURY; KAPPA-B; CELL-DEATH; IN-VITRO; PATHWAY; SALIDROSIDE;
   INFLAMMATION; MODEL; CARDIOMYOCYTES; CHRYSOPHANOL
AB The purpose of the present study was to evaluate the protective effect of betulin (BE) on CS (cigarette smoke)-induced COPD in mice and explore its underlying mechanisms. 60 male ICR mice were randomly assigned to five groups: control group, model group, dexamethasone (2 mg/kg) group, BE (20 mg/kg) group and BE (40 mg/kg) group. The COPD mice were induced by cigarette smoke exposure for 8 weeks. The result of H&E staining demonstrated that BE inhibited CS-induced pathological injury in lung tissue. Besides, BE could restore the activities of superoxide dismutase (SOD) in serum and in lung, catalase (CAT) in serum and reduce the content of malondialdehyde (MDA) in serum and in lung. BE also inhibited the overproductions of pro-inflammatory cytokines including tumor necrosis factor-a (TNF-alpha), interleukin-6 (IL-6) and interleukin-1 beta (IL-1 beta). Furthermore, the administration of BE significantly inhibited the protein expression of ROCK/NF-kappa B pathway in CS-induced mice. Our findings suggested that BE might effectively ameliorate the progression of COPD via ROCK/NF-kappa B pathway in mice. (C) 2016 Elsevier Masson SAS. All rights reserved.
C1 [Ma Chunhua; Long Hongyan; Zhu Weina; Liu Zheng; Ruan Jie; Zhang Yajie; Wang Yarui] Nanjing Univ TCM, Cent Lab, Nanjing Municipal Hosp TCM, Affiliated Hosp 3, Nanjing 210001, Jiangsu, Peoples R China.
C3 Nanjing University of Chinese Medicine
RP Long, HY (corresponding author), Nanjing Univ TCM, Cent Lab, Nanjing Municipal Hosp TCM, Affiliated Hosp 3, Nanjing 210001, Jiangsu, Peoples R China.
EM longhongyantcm@163.com
RI Ma, Chunhua/NFS-9026-2025
FU National twelve five major drug discovery project [2011ZX09102-002-01]
FX This work was supported by National twelve five major drug discovery
   project (2011ZX09102-002-01).
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SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
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PD JAN
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BP 679
EP 686
DI 10.1016/j.biopha.2016.11.079
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA EM7WK
UT WOS:000395522800078
PM 27899253
DA 2026-05-27
ER

PT J
AU Peng, JF
   Salami, OM
   Lei, C
   Ni, D
   Habimana, O
   Yi, GH
AF Peng, Jin-Fu
   Salami, Oluwabukunmi Modupe
   Lei, Cai
   Ni, Dan
   Habimana, Olive
   Yi, Guang-Hui
TI Targeted mitochondrial drugs for treatment of myocardial
   ischaemia-reperfusion injury
SO JOURNAL OF DRUG TARGETING
LA English
DT Review
DE Myocardial ischaemia-reperfusion injury; targeting mitochondrial quality
   control; targeting mitochondrial quantity control; targeted
   mitochondrial drugs
ID POST-CONDITIONING PROTECTS; ISCHEMIA/REPERFUSION INJURY; THERAPEUTIC
   TARGET; QUALITY-CONTROL; FISSION; DYNAMICS; MECHANISMS; FUSION;
   CARDIOPROTECTION; SALIDROSIDE
AB Myocardial ischaemia-reperfusion injury (MI/RI) refers to the further damage done to ischaemic cardiomyocytes when restoring blood flow. A large body of evidence shows that MI/RI is closely associated with excessive production of mitochondrial reactive oxygen species, mitochondrial calcium overload, disordered mitochondrial energy metabolism, mitophagy, mitochondrial fission, and mitochondrial fusion. According to the way it affects mitochondria, it can be divided into mitochondrial quality abnormalities and mitochondrial quantity abnormalities. Abnormal mitochondrial quality refers to the dysfunction caused by the severe destruction of mitochondria, which then affects the balance of mitochondrial density and number, causing an abnormal mitochondrial quantity. In the past, most of the reports were limited to the study of the mechanism of myocardial ischaemia-reperfusion injury, some of which involved mitochondria, but no specific countermeasures were proposed. In this review, we outline the mechanisms for treating myocardial ischaemia-reperfusion injury from the direction of mitochondria and focus on targeted interventions and drugs to restore mitochondrial health during abnormal mitochondrial quality control and abnormal mitochondrial quantity control. This is an update in the field of myocardial ischaemia-reperfusion injury.
C1 [Peng, Jin-Fu; Yi, Guang-Hui] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Inst Pharm & Pharmacol, Hengyang, Peoples R China.
   [Peng, Jin-Fu; Lei, Cai; Ni, Dan; Yi, Guang-Hui] Univ South China, Hengyang Med Sch, Hunan Int Sci & Technol Cooperat Base Arterioscle, Inst Cardiovasc,Dis Key Lab Arteriosclerotic Dis, 28 Changsheng West Rd, Hengyang 421001, Peoples R China.
   [Salami, Oluwabukunmi Modupe; Habimana, Olive] Univ South China, Internat Coll, Hengyang, Peoples R China.
C3 University of South China; University of South China; University of
   South China
RP Yi, GH (corresponding author), Univ South China, Hengyang Med Sch, Hunan Int Sci & Technol Cooperat Base Arterioscle, Inst Cardiovasc,Dis Key Lab Arteriosclerotic Dis, 28 Changsheng West Rd, Hengyang 421001, Peoples R China.
EM ghyi6108@163.com
OI Salami, Oluwabukunmi/0000-0002-2226-2488
FU National Natural Sciences Foundation of China [81770490]; Planned
   Science and Technology Project of Hunan Province, China [2020JJ4535]
FX This work was supported by the National Natural Sciences Foundation of
   China [No. 81770490], the Planned Science and Technology Project of
   Hunan Province, China [No.2020JJ4535].
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NR 111
TC 13
Z9 15
U1 4
U2 74
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1061-186X
EI 1029-2330
J9 J DRUG TARGET
JI J. Drug Target.
PD AUG 24
PY 2022
VL 30
IS 8
BP 833
EP 844
DI 10.1080/1061186X.2022.2085728
EA JUN 2022
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 3X1UC
UT WOS:000818802200001
PM 35652502
DA 2026-05-27
ER

PT J
AU Jia, TJ
   Nazir, MF
   Bovio-Zenteno, EM
   Dai, LY
   Xu, J
   Zhao, YF
   Zou, SY
AF Jia, Tianjiao
   Nazir, Mian Faisal
   Bovio-Zenteno, Edgar Manuel
   Dai, Longyu
   Xu, Jie
   Zhao, Yafang
   Zou, Shuaiyu
TI Widely Targeted Metabolomics Analysis Reveals Developmental Shifts in
   Antioxidants and Functional Peptides in Akebia trifoliata
SO ANTIOXIDANTS
LA English
DT Article
DE <italic>Akebia trifoliata</italic>; widely targeted metabolomics;
   secondary metabolites; bioactive compounds; oligopeptides
ID FRUIT; TRITERPENOIDS; SALIDROSIDE; CAPACITY; MATURITY; QUALITY; LEAVES
AB Akebia trifoliata is an emerging fruit crop in China, valued for its medicinal and nutritional properties. To elucidate the developmental dynamics of its bioactive compounds, we performed widely targeted metabolomics using Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry (UPLC-MS/MS) across four fruit developmental stages (S1-S4). A total of 1595 metabolites were identified, of which 988 were differentially accumulated and categorized into three distinct accumulation patterns. Flavonoids and phenolic acids exhibited a marked decline during fruit maturation, corresponding with decreasing antioxidant and alpha-glucosidase inhibitory activities. Conversely, functional oligopeptides and specific terpenoids accumulated significantly at later stages. K-means clustering revealed dynamic shifts in metabolic profiles, and 23 functional oligopeptides with antioxidative, antidiabetic, and ACE-inhibitory activities (angiotensin-converting enzyme, ACE) were predicted. KEGG enrichment highlighted stage-specific pathway transitions from flavonoid biosynthesis during early development to sugar metabolism at ripening. Correlation analysis identified key flavonoids, phenolic acids, and amino acid derivatives associated with antioxidant capacity and alpha-glucosidase inhibition. This study provides comprehensive metabolomic landscape of A. trifoliata fruit development and offers valuable insights for its functional exploitation in food and medicinal applications.
C1 [Jia, Tianjiao; Nazir, Mian Faisal; Bovio-Zenteno, Edgar Manuel; Dai, Longyu; Xu, Jie; Zhao, Yafang; Zou, Shuaiyu] Jiangxi Prov & Chinese Acad Sci, Lushan Bot Garden, Jiujiang 332900, Peoples R China.
   [Bovio-Zenteno, Edgar Manuel] Univ Veracruzana, Inst Biotecnol & Ecol Aplicada INBIOTECA, Av Culturas Veracruzanas 101,Col E Zapata, Xalapa 91090, Veracruz, Mexico.
C3 Chinese Academy of Sciences; Universidad Veracruzana
RP Zou, SY (corresponding author), Jiangxi Prov & Chinese Acad Sci, Lushan Bot Garden, Jiujiang 332900, Peoples R China.
EM jiatj@lsbg.cn; mfn121@hotmail.com; boviozentenoedgar@gmail.com;
   dlongyu1997@163.com; xj13707060350@163.com; fang10302021@163.com;
   zousy@lsbg.cn
RI Nazir, Mian Faisal/AAO-1942-2021
OI Nazir, Mian Faisal/0000-0002-7097-181X; Bovio Zenteno, Edgar
   Manuel/0009-0008-6209-9882
FU National Natural Science Foundation of China; Natural Science Foundation
   of Jiangxi Province [20232BAB216121]; Jiujiang City Talent Project
   [JJXC2023134, S2024KXJJ0001];  [32460101]
FX This research was funded by the National Natural Science Foundation of
   China (32460101), the Natural Science Foundation of Jiangxi Province
   (20232BAB216121), the Jiujiang City Talent Project (JJXC2023134), and
   the Science and Technology Project of Jiujiang (S2024KXJJ0001).
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NR 62
TC 0
Z9 0
U1 7
U2 9
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD AUG 24
PY 2025
VL 14
IS 9
AR 1039
DI 10.3390/antiox14091039
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 7TS2I
UT WOS:001579432900001
PM 41008949
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Mei, HD
   Xu, X
   Xu, SN
AF Mei, Handong
   Xu, Xiao
   Xu, Sinan
TI Sargent Gloryvine Extract Modulates Nuclear Factor κB Signaling Pathway
   to Improve Severe Pancreatitis
SO CURRENT TOPICS IN NUTRACEUTICAL RESEARCH
LA English
DT Article
DE Network pharmacology; NF kappa B; Sargent gloryvine; Severe pancreatitis
ID INJURY
AB This study explored the mechanism of action of Sargent gloryvine extract in treating severe pancreatitis. We used the PubChem and SwissTargetPredicton databases to predict the potential targets. The database for Annotation, Visualization, and Integrated Discovery was used to perform Gene Ontology. The Kyoto Encyclopedia of Genes was used to perform Genomes enrichment analyses. These analyses, visualized via Cytoscape software followed by molecular docking validation, identified Salidroside, Lignans, Emodin, and Physcion as key active compounds in the extract. The protein-protein interaction network analysis highlighted tumor necrosis factor, interleukin-6, and nuclear factor kappa B as critical targets with 42 signaling pathways identified as relevant. The nuclear factor kappa B pathway emerged as especially significant in the extract's effect on severe pancreatitis. Enrichment analysis screened 42 related signaling pathways, among which the nuclear factor kappa B pathway may play a vital role in treating severe pancreatitis with Sargent gloryvine extract. The molecular docking results indicated an excellent binding activity between Sargent gloryvine extract and nuclear factor kappa B. In conclusion, the therapeutic approach of Sargent gloryvine extract in severe pancreatitis involves a complex interaction of multiple components, targets, and pathways, with a potential mechanism linked to the downregulation of the nuclear factor kappa B signaling pathway.
C1 [Mei, Handong; Xu, Xiao] Jinhua Municipal Cent Hosp, Dept Crit Care Med, Jinhua 321000, Zhejiang, Peoples R China.
   [Xu, Sinan] Haining Peoples Hosp, Dept Gastroenterol, Haining 314400, Zhejiang, Peoples R China.
RP Mei, HD (corresponding author), Jinhua Municipal Cent Hosp, Dept Crit Care Med, Jinhua 321000, Zhejiang, Peoples R China.
EM mhd7291@163.com
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NR 21
TC 0
Z9 0
U1 1
U2 2
PU NEW CENTURY HEALTH PUBLISHERS, LLC
PI COPPELL
PA PO BOX 175, COPPELL, TX 75019 USA
SN 1540-7535
EI 2641-452X
J9 CURR TOP NUTRACEUT R
JI Curr. Top. Nutraceutical Res.
PD MAY
PY 2024
VL 22
IS 2
BP 405
EP 411
PG 7
WC Nutrition & Dietetics; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Pharmacology & Pharmacy
GA SU8J3
UT WOS:001237048800006
DA 2026-05-27
ER

PT J
AU Li, CL
   Li, Y
   Huang, X
   Li, S
   Sangji, KZ
   Gu, R
AF Li, Canlin
   Li, Yuan
   Huang, Xi
   Li, Si
   Sangji, Kangzhuo
   Gu, Rui
TI Traditional Tibetan medicine: therapeutic potential in lung diseases
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE traditional Tibetan medicine; natural medicine; lung diseases;
   pharmacological properties; bioactive components
ID INDUCED PULMONARY-FIBROSIS; NF-KAPPA-B; SIGNALING PATHWAY; TOTAL
   FLAVONOIDS; CANCER CELLS; IN-VITRO; SALIDROSIDE; INJURY; PROTECTS;
   INFLAMMATION
AB Lung diseases have become a major threat to human health worldwide. Despite advances in treatment and intervention in recent years, effective drugs are still lacking for many lung diseases. As a traditional natural medicine, Tibetan medicine has had a long history of medicinal use in ethnic minority areas, and from ancient times to the present, it has a good effect on the treatment of lung diseases and has attracted more and more attention. In this review, a total of 586 Tibetan medicines were compiled through literature research of 25 classical works on Tibetan medicine, drug standards, and some Chinese and English databases. Among them, 33 Tibetan medicines have been studied to show their effectiveness in treating lung diseases. To investigate the uses of these Tibetan medicines in greater depth, we have reviewed the ethnomedicinal, phytochemical and pharmacological properties of the four commonly used Tibetan medicines for lung diseases (rhodiola, gentian, sea buckthorn, liexiang dujuan) and the five most frequently used Tibetan medicines (safflower, licorice, sandalwood, costus, myrobalan). It is expected to provide some reference for the development of new drugs of lung diseases in the future.
C1 [Li, Canlin; Sangji, Kangzhuo; Gu, Rui] Chengdu Univ Tradit Chinese Med, Sch Ethn Med, Chengdu, Peoples R China.
   [Li, Yuan; Huang, Xi; Li, Si] Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine
RP Gu, R (corresponding author), Chengdu Univ Tradit Chinese Med, Sch Ethn Med, Chengdu, Peoples R China.
EM gurui@cdutcm.edu.cn
OI Li, Yuan/0009-0002-8703-431X
FU Ministry of Science and Technology of the People's Republic of China
   [2019YFC1712305]; National Natural Science Foundation of China
   [82073964]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This work was supported
   by the Ministry of Science and Technology of the People's Republic of
   China (No. 2019YFC1712305), and the National Natural Science Foundation
   of China (No. 82073964).
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NR 191
TC 11
Z9 14
U1 13
U2 48
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD MAR 18
PY 2024
VL 15
AR 1365911
DI 10.3389/fphar.2024.1365911
PG 23
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA MO2P4
UT WOS:001194501000001
PM 38567353
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Han, R
   Han, GY
   Yan, YQ
   Han, LF
   Li, L
   Zhang, H
AF Han, Rui
   Han, Guoying
   Yan, Yiqi
   Han, Lifeng
   Li, Lin
   Zhang, Han
TI Protective effects and mechanisms of the Erzhi formula on glucocorticoid
   induced primary cortical neuron injury
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE the erzhi formula; primary cortical neuron; stress; depression;
   glucocorticoids; apoptosis; synaptic plasticity; network analysis
ID DEHYDROGENASE TYPE-1; STRESS; EXPRESSION; BRAIN; APOPTOSIS
AB High concentrations of glucocorticoids (GC) can cross the blood-brain barrier into the brain parenchyma, triggering a stress state that can lead to a range of physiological changes. This study investigated whether Erzhi formula has neuroprotective effects against glucocorticoid damage by establishing a dexamethasone-induced primary cortical neuron injury model in vitro. The results showed that Erzhi formula could reduce dexamethasone-induced apoptosis in primary cultured cortical neurons and improve synaptic damage. Further, network pharmacological analysis revealed that Erzhi formula may exert antidepressant effects by multi-component, multi-target, and multi-pathway characteristics, in which Salidroside, Biochanin-A and other ingredients are key components, HSD11B1, NR3C1, and other proteins are key targets, and steroid metabolism may be a key process in its action. Moreover, our study found that the neuroprotective effect of Erzhi formula might be related to the 11 beta-HSD1-GC/glucocorticoid receptor (GR) signaling pathway. The Erzhi formula could significantly inhibit the activity of 11 beta-hydroxysteroid dehydrogenase 1 (11 beta-HSD1) in vitro using homogeneous time-resolved fluorescence. In addition to providing evidence for the pharmacological effects of the Erzhi formula, the present study lays down the foundation for subsequent experiments.
C1 [Han, Rui; Han, Guoying; Yan, Yiqi; Han, Lifeng; Li, Lin; Zhang, Han] Tianjin Univ Tradit Chinese Med, Inst Tradit Chinese Med, Tianjin, Peoples R China.
   [Han, Rui; Han, Guoying; Yan, Yiqi; Li, Lin; Zhang, Han] Tianjin Univ Tradit Chinese Med, Key Lab Pharmacol Tradit Chinese Med Formulae, Minist Educ, Tianjin, Peoples R China.
   [Han, Rui; Han, Guoying; Yan, Yiqi; Han, Lifeng; Li, Lin; Zhang, Han] Tianjin Univ Tradit Chinese Med, State Key Lab Component Based Chinese Med, Tianjin, Peoples R China.
C3 Tianjin University of Traditional Chinese Medicine; Tianjin University
   of Traditional Chinese Medicine; Tianjin University of Traditional
   Chinese Medicine
RP Li, L; Zhang, H (corresponding author), Tianjin Univ Tradit Chinese Med, Inst Tradit Chinese Med, Tianjin, Peoples R China.; Li, L; Zhang, H (corresponding author), Tianjin Univ Tradit Chinese Med, Key Lab Pharmacol Tradit Chinese Med Formulae, Minist Educ, Tianjin, Peoples R China.; Li, L; Zhang, H (corresponding author), Tianjin Univ Tradit Chinese Med, State Key Lab Component Based Chinese Med, Tianjin, Peoples R China.
EM 13516122373@126.com; zhanghan0023@126.com
RI Li, Lin/ABF-3496-2022; Yang, Yiqi/A-6900-2009
OI Li, Lin/0000-0002-1103-2185; 
FU National Natural Science Foundation of China [81973792]; Innovation Team
   and Talents Cultivation Program of National Administration of
   Traditional Chinese Medicine [ZYYCXTD-C-202009]
FX This work was supported by National Natural Science Foundation of China
   (81973792). This work is supported by Innovation Team and Talents
   Cultivation Program of National Administration of Traditional Chinese
   Medicine (No: ZYYCXTD-C-202009).
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NR 38
TC 7
Z9 7
U1 0
U2 17
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD FEB 27
PY 2023
VL 14
AR 1038492
DI 10.3389/fphar.2023.1038492
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 9U7LA
UT WOS:000947886800001
PM 36923359
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zdanowski, R
   Lewicki, S
   Skopinska-Rózewska, E
   Buchwald, W
   Mrozikiewicz, PM
   Stankiewicz, W
AF Zdanowski, Robert
   Lewicki, Slawomir
   Skopinska-Rozewska, Ewa
   Buchwald, Waldemar
   Mrozikiewicz, Przemyslaw Michal
   Stankiewicz, Wanda
TI Alcohol- and water-based extracts obtained from Rhodiola rosea
   affect differently the number and metabolic activity of circulating
   granulocytes in Balb/c mice
SO ANNALS OF AGRICULTURAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article
DE Rhodiola rosea; mice; granulocytes; chemiluminescence
ID POLYMORPHONUCLEAR LEUKOCYTES; QUADRIFIDA EXTRACTS; PHAGOCYTIC FUNCTION;
   CHEMI-LUMINESCENCE; CELLULAR-IMMUNITY; IN-VITRO; SALIDROSIDE;
   ANGIOGENESIS; CELLS; APOPTOSIS
AB Introduction and objective. Rhodiola rosea (RR) rhizomes with root extracts are traditional natural drugs originating from Asia and now commonly used as adaptogens and antidepressants. The aim of the presented study was to examine the in vivo effect of aqueous (RRW) and 50% hydro-alcoholic (RRA) extracts on the number and metabolic activity of blood granulocytes in mice.
   Material and methods. Mice were fed for 7 days with RR extract at daily doses of 0.05, 0.1, 0.2 or 0.4 mg. The metabolic activity of blood granulocytes was determined by measuring of their luminol-dependent chemiluminescent activity on a scintillation counter, after zymosan stimulation.
   Results. The number of blood granulocytes was diminished and their chemiluminescence was enhanced in all groups of mice fed R.rosea hydro-alcoholic extract. Aqueous extract (RRW) was ineffective in all doses applied.
   Conclusion. The presented study revealed difference in the number and metabolic activity of granulocytes mice fed RRA or RRW extracts. Immune characteristics of some individual compounds from RRA and RRW extracts, selected by HPLC analysis, should be carried out in subsequent experiments.
C1 [Zdanowski, Robert; Lewicki, Slawomir] Mil Inst Hyg & Epidemiol, Dept Regenerat Med, PL-03352 Warsaw, Poland.
   [Skopinska-Rozewska, Ewa] Med Univ Warsaw, Dept Pathol, Biostruct Ctr, Warsaw, Poland.
   [Buchwald, Waldemar] Inst Nat Fibres & Med Plants, Dept Bot Breeding & Agr, Team Bot & Agr Med Plants, Plewiska, Poland.
   [Mrozikiewicz, Przemyslaw Michal] Poznan Univ Med Sci, Dept Clin Pharm & Biopharm, Lab Expt Pharmacogenet, Poznan, Poland.
   [Mrozikiewicz, Przemyslaw Michal] Inst Nat Fibres & Med Plants, Dept Qual Control Med Prod & Dietary Supplements, Poznan, Poland.
   [Stankiewicz, Wanda] Mil Inst Hyg & Epidemiol, Dept Microwawe Safety, PL-03352 Warsaw, Poland.
C3 Military Institute of Hygiene & Epidemiology (MIHE); Medical University
   of Warsaw; Institute of Natural Fibres & Medicinal Plants; Poznan
   University of Medical Sciences; Institute of Natural Fibres & Medicinal
   Plants; Military Institute of Hygiene & Epidemiology (MIHE)
RP Lewicki, S (corresponding author), Mil Inst Hyg & Epidemiol, Dept Regenerat Med, Boleslawicka 17-9, PL-03352 Warsaw, Poland.
EM lewickis@gmail.com
RI Lewicki, Sławomir/AAZ-4709-2020
OI Lewicki, Sławomir/0000-0002-0539-0680; Buchwald,
   Waldemar/0000-0002-4180-510X; Zdanowski, Robert/0000-0003-0455-1072
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NR 23
TC 14
Z9 16
U1 0
U2 9
PU INST AGRICULTURAL MEDICINE
PI LUBLIN
PA JACZEWSKIEGO 2, PO BOX 185, 20-950 LUBLIN, POLAND
SN 1232-1966
EI 1898-2263
J9 ANN AGR ENV MED
JI Ann. Agr. Env. Med.
PY 2014
VL 21
IS 1
BP 120
EP 123
PG 4
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA AE3HO
UT WOS:000333867800022
PM 24738509
DA 2026-05-27
ER

PT J
AU Zhang, WL
   Zhu, L
   Jiang, JG
AF Zhang, W. -L.
   Zhu, L.
   Jiang, J. -G.
TI Active ingredients from natural botanicals in the treatment of obesity
SO OBESITY REVIEWS
LA English
DT Review
DE Active ingredients; obesity; traditional Chinese medicine; treatment
ID CHINESE MEDICINE; BODY-WEIGHT; FOOD-INTAKE; OVERWEIGHT; INHIBITORS;
   BURDEN; LINK
AB Obesity is considered as a chronic disease that can induce a series of comorbidities and complications. Chinese medicine has long clinical experiences in the treatment of obesity. This review summarizes the natural products from traditional Chinese medicine (TCM) that are reported to have anti-obesity effects in the past two decades. Botanic TCM comprises 90% of total Chinese crude drugs, and generally contains various active ingredients, in which the effective anti-obesity ingredients identified can be divided into saponins, polysaccharides, alkaloids, polyphenols and others. Astragaloside IV, glycyrrhizin, macrostemonoside A, berberine, betaine, capsaicin, matrine, methyl piperate, piperine, rutaecarpine, asimilobine, epigallocatechingallate, magnolol, resveratrol, soybean-isoflavone, -linolenic acid, emodin, geniposide, phillyrin, salidroside and ursolic acid are specified in this review, and their sources, models, efficacy are described. It is concluded that the mechanisms of these components for the treatment of obesity include: (i) suppression of appetite, increase of satiety, reduction of energy intake; (ii) reduction in the digestion and absorption of exogenous lipid; (iii) attenuation of the synthesis of endogenous lipid; (iv) promotion of the oxidation and expenditure of lipid and (v) improvement of lipid metabolism disorder. Authors believe that the effective compounds from TCM will provide an alternative and hopeful way for the treatment of obesity.
C1 [Zhang, W. -L.; Zhu, L.; Jiang, J. -G.] S China Univ Technol, Coll Food & Bioengn, Guangzhou 510640, Guangdong, Peoples R China.
C3 South China University of Technology
RP Zhu, L (corresponding author), S China Univ Technol, Coll Food & Bioengn, Guangzhou 510640, Guangdong, Peoples R China.
EM zhuliang@scut.edu.cn; jgjiang@scut.edu.cn
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NR 116
TC 121
Z9 132
U1 3
U2 165
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1467-7881
EI 1467-789X
J9 OBES REV
JI Obes. Rev.
PD DEC
PY 2014
VL 15
IS 12
BP 957
EP 967
DI 10.1111/obr.12228
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AU5EY
UT WOS:000345631100003
PM 25417736
DA 2026-05-27
ER

PT J
AU Ma, YC
   Wang, XQ
   Hou, FF
   Ma, J
   Luo, M
   Lu, S
   Jin, P
   Chen, A
   Xu, I
   Patel, AV
   Gorecki, D
AF Ma, Yuan-Chun
   Wang, Xiao-Qiang
   Hou, FeiFei
   Ma, Jie
   Luo, Mai
   Lu, Shane
   Jin, Peter
   Chen, Alice
   Xu, Iris
   Patel, Asmita V.
   Gorecki, Derek
TI Simultaneous quantification of polyherbal formulations containing
   Rhodiola rosea L. and Eleutherococcus senticosus Maxim.
   using rapid resolution liquid chromatography (RRLC)
SO JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
LA English
DT Article
DE Rhodiola rosea L.; Eleutherococcus senticosus; Rapid resolution liquid
   chromatography (RRLC); Polyherbal formulation
ID QUANTITATIVE-DETERMINATION; ACANTHOPANAX-SENTICOSUS; MASS-SPECTROMETRY;
   GLYCOSIDES; PLANTS
AB An RRLC method capable of simultaneous identification and rapid quantification of six biologically active compounds (salidroside, tyrosol, rosarin, rosavin, rosin, rosiridin) in Rhodiola rosea L and two active compounds (eleutheroside B and eleutheroside E) in Eleutherococcus senticosus Maxim, was developed. The chromatographic analyses were performed on a reversed phase Phenomenex C18 (2)-HST column at 40 degrees C with a neutral mobile phase (purified water and acetonitrile) gradient system at a flow rate of 1.0 ml/min and UV detection at 205 and 220 nm simultaneously. Baseline separation of eight active compounds was achieved within 8 min. This developed method provides good linearity (R > 0.9997). precision (RSD < 1.99%) and recovery of the bioactive compounds. The RRLC method developed is capable of controlling the quality of R. rosea and E. senticosus raw herbs, commercial extracts, as well as polyherbal formulations containing R. rosea and E. senticosus as ingredients. This RRLC method is accurate and sensitive; in addition, it greatly increases sample analysis throughput with reduced analysis time, which is suitable for routine quality control analysis. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Ma, Yuan-Chun; Wang, Xiao-Qiang; Hou, FeiFei; Ma, Jie; Luo, Mai; Lu, Shane; Jin, Peter; Chen, Alice; Xu, Iris] Canadian Phytopharmaceut Corp, Richmond, BC V6W 1K8, Canada.
   [Ma, Yuan-Chun; Wang, Xiao-Qiang; Ma, Jie] Canadian Inst Med Plants, Richmond, BC V6W 1K8, Canada.
   [Ma, Jie; Patel, Asmita V.; Gorecki, Derek] Univ Portsmouth, Sch Pharm & Biomed Sci, Portsmouth PO1 2DT, Hants, England.
C3 University of Portsmouth
RP Ma, J (corresponding author), Canadian Phytopharmaceut Corp, 12233 Riverside Way, Richmond, BC V6W 1K8, Canada.
EM jiem0121@gmail.com
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NR 28
TC 21
Z9 22
U1 0
U2 28
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0731-7085
J9 J PHARMACEUT BIOMED
JI J. Pharm. Biomed. Anal.
PD JUL 15
PY 2011
VL 55
IS 5
BP 908
EP 915
DI 10.1016/j.jpba.2011.03.013
PG 8
WC Chemistry, Analytical; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Pharmacology & Pharmacy
GA 771AN
UT WOS:000291129700007
PM 21466940
DA 2026-05-27
ER

PT J
AU Rumalla, CS
   Avula, B
   Ali, Z
   Smillie, TJ
   Filion, V
   Cuerrier, A
   Arnason, JT
   Khan, IA
AF Rumalla, Chidananda Swamy
   Avula, Bharathi
   Ali, Zulfiqar
   Smillie, Troy J.
   Filion, Vicky
   Cuerrier, Alain
   Arnason, John T.
   Khan, Ikhlas A.
TI Quantitative HPTLC Analysis of Phenylpropanoids in Rhodiola
   Species
SO JPC-JOURNAL OF PLANAR CHROMATOGRAPHY-MODERN TLC
LA English
DT Article
DE Phenylpropanoids; Rhodiola rosea; Rhodiola sachalinensis; Validation;
   HPTLC
ID QUALITY-CONTROL; ROSEA; PERFORMANCE; IDENTIFICATION; SALIDROSIDE;
   PHENYLALKANOIDS; EXTRACTION
AB A simple and rapid HPTLC method with densitometric detection has been established for analysis of rosin, rosarin, and rosavin, three marker compounds from the roots of Rhodiola rosea L. and Rhodiola sachalinensis Borissova. The method was successfully used for quantitative evaluation of commercial samples. Separation on silica gel HPTLC plates was achieved with chloroform-methanol-water 65:35:10.5 (v/v) as mobile phase. After development, plates were observed under UV light at 250 nm. The method was validated for linearity, precision, accuracy, and limits of detection (LOD) and quantification (LOQ). The calibration plots were linear in the range 100 to 500 ng per band with all correlation coefficients >0.999. Recovery of the three compounds was between 97 and 101%. The LOD and LOQ were 30 and 100 ng per band, respectively, for all three compounds. The rosin, rosarin, and rosavin content of Rhodiola rosea L. was 0.059, 0.238, and 0.421% (w/w), respectively. Rhodiola sachalinensis Borissova contained 0.034 and 0.109% (w/w) rosarin and rosavin, respectively. The method, which has the advantages of rapid sample preparation and simplicity, can be used for routine quality-control analysis of commercial preparations and for stability studies.
C1 [Khan, Ikhlas A.] Univ Mississippi, Sch Pharm, Pharmaceut Sci Res Inst, Natl Ctr Nat Prod Res, University, MS 38677 USA.
   [Khan, Ikhlas A.] Univ Mississippi, Sch Pharm, Dept Pharmacognosy, University, MS 38677 USA.
   [Filion, Vicky; Arnason, John T.] Univ Ottawa, Dept Biol, Ctr Adv Res Environm Genom, Ottawa, ON K1N 6N5, Canada.
   [Cuerrier, Alain] Univ Montreal, Plant Biol Res Inst, Montreal, PQ H1X 2B2, Canada.
C3 University of Mississippi; University of Mississippi; University of
   Ottawa; Universite de Montreal
RP Khan, IA (corresponding author), Univ Mississippi, Sch Pharm, Pharmaceut Sci Res Inst, Natl Ctr Nat Prod Res, University, MS 38677 USA.
EM ikhan@olemiss.edu
RI Khan, Ikhlas/AAA-1829-2020; Arnason, John/GXM-3860-2022
FU United States Department of Agriculture, Agricultural Research Service
   [58-6408-2-0009]; Food and Drug Administration [5U01FD002071-09,
   1U0FD00387-01]
FX This research was funded in part by The United States Department of
   Agriculture, Agricultural Research Service, Specific Cooperative
   Agreement No. 58-6408-2-0009. Botanical Dietary Supplement Research
   funded by the Food and Drug Administration grant numbers 5U01FD002071-09
   and 1U0FD00387-01.
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NR 16
TC 6
Z9 6
U1 0
U2 19
PU AKADEMIAI KIADO ZRT
PI BUDAPEST
PA BUDAFOKI UT 187-189-A-3, H-1117 BUDAPEST, HUNGARY
SN 0933-4173
EI 1789-0993
J9 JPC-J PLANAR CHROMAT
JI JPC-J. Planar Chromatogr.-Mod. TLC
PD APR
PY 2011
VL 24
IS 2
BP 116
EP 120
DI 10.1556/JPC.24.2011.2.6
PG 5
WC Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA 761TM
UT WOS:000290423900006
DA 2026-05-27
ER

PT J
AU Yang, KL
   Zeng, LT
   He, Q
   Wang, SS
   Xu, H
   Ge, JW
AF Yang, Kailin
   Zeng, Liuting
   He, Qi
   Wang, Shanshan
   Xu, Hao
   Ge, Jinwen
TI Advancements in research on the immune-inflammatory mechanisms mediated
   by NLRP3 inflammasome in ischemic stroke and the regulatory role of
   natural plant products
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE ischemic stroke; NLRP3 inflammasome; immune mechanism; inflammatory
   mechanism; natural plant products
ID CEREBRAL ISCHEMIA/REPERFUSION INJURY; SULFORAPHANE PROTECTS; REPERFUSION
   INJURY; PANAX-NOTOGINSENG; GINSENOSIDE RD; ACTIVATION; AUTOPHAGY;
   NEUROPROTECTION; NEURONS; OXYGEN
AB Ischemic stroke (IS) is a major cause of mortality and disability among adults. Recanalization of blood vessels to facilitate timely reperfusion is the primary clinical approach; however, reperfusion itself may trigger cerebral ischemia-reperfusion injury. Emerging evidence strongly implicates the NLRP3 inflammasome as a potential therapeutic target, playing a key role in cerebral ischemia and reperfusion injury. The aberrant expression and function of NLRP3 inflammasome-mediated inflammation in cerebral ischemia have garnered considerable attention as a recent research focus. Accordingly, this review provides a comprehensive summary of the signaling pathways, pathological mechanisms, and intricate interactions involving NLRP3 inflammasomes in cerebral ischemia-reperfusion injury. Moreover, notable progress has been made in investigating the impact of natural plant products (e.g., Proanthocyanidins, methylliensinine, salidroside, alpha-asarone, acacia, curcumin, morin, ginsenoside Rd, paeoniflorin, breviscapine, sulforaphane, etc.) on regulating cerebral ischemia and reperfusion by modulating the NLRP3 inflammasome and mitigating the release of inflammatory cytokines. These findings aim to present novel insights that could contribute to the prevention and treatment of cerebral ischemia and reperfusion injury.
C1 [Yang, Kailin; Wang, Shanshan; Xu, Hao; Ge, Jinwen] Hunan Univ Chinese Med, Sch Integrated Chinese & Western Med, Key Lab Hunan Prov Integrated Tradit Chinese & Wes, Changsha, Peoples R China.
   [Yang, Kailin; Ge, Jinwen] Hunan Acad Chinese Med, Changsha, Hunan, Peoples R China.
   [Zeng, Liuting] Chinese Acad Med Sci & Peking Union Med Coll, Grad Sch, Beijing, Peoples R China.
   [He, Qi] Peoples Hosp Ningxiang City, Dept Crit Care Med, Ningxiang, Peoples R China.
C3 Hunan University of Chinese Medicine; Hunan University of Chinese
   Medicine; Chinese Academy of Medical Sciences - Peking Union Medical
   College; Peking Union Medical College
RP Ge, JW (corresponding author), Hunan Univ Chinese Med, Sch Integrated Chinese & Western Med, Key Lab Hunan Prov Integrated Tradit Chinese & Wes, Changsha, Peoples R China.; Ge, JW (corresponding author), Hunan Acad Chinese Med, Changsha, Hunan, Peoples R China.
EM 001267@hnucm.edu.cn
RI ; Kailin, Yang/IWU-6739-2023; Zeng, Liuting/OVZ-3753-2025; 曾,
   柳庭/OVZ-3753-2025
OI Yang, Kailin/0000-0002-1442-8644; 曾, 柳庭/0000-0003-4654-8760
FU National Key Research and Development Project of China [2018YFC1704904];
   National Natural Science Foundation of China [81774174]; Provincial
   Discipline Construction Project of Hunan University of Chinese Medicine;
   Postgraduate Scientific Research Innovation Project of Hunan Province
   [CX20230800]
FX The research is supported by National Key Research and Development
   Project of China (No. 2018YFC1704904), the National Natural Science
   Foundation of China (81774174), the Provincial Discipline Construction
   Project of Hunan University of Chinese Medicine (Integrated Traditional
   Chinese and Western Medicine) and the Postgraduate Scientific Research
   Innovation Project of Hunan Province (CX20230800).
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NR 188
TC 22
Z9 24
U1 2
U2 22
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD MAR 27
PY 2024
VL 15
AR 1250918
DI 10.3389/fphar.2024.1250918
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA NE6V0
UT WOS:001198824900001
PM 38601463
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Li, CJ
   Song, LL
   Zhou, Y
   Yuan, JS
   Zhang, SC
AF Li, Congjun
   Song, Lili
   Zhou, Yang
   Yuan, Jiangshui
   Zhang, Shicui
TI Identification of Isthmin1 in the small annual fish, Nothobranchius
   guentheri, as a novel biomarker of aging and its potential
   rejuvenation activity
SO BIOGERONTOLOGY
LA English
DT Article
DE Annual fish; Nothobranchius; Aging; Biomarkers; Lifespan; Isthmin
ID ANNUAL CYPRINODONT FISH; AGE-RELATED MARKERS; PROLONGS LIFE-SPAN;
   VERTEBRATE MODEL; IMMUNE-RESPONSE; GROWTH; ONSET; RESVERATROL;
   EXPRESSION; SYSTEM
AB Isthmin 1 (Ism1) has been shown to play roles in multiple biological processes including morphogenesis, hematopoiesis, antiviral immune response and suppression of tumor growth. However, it remains unknown if it plays any role in aging process. Here we showed for the first time that Ism1 was a new age-related biomarker, which decreased with age in fish, mice and humans. Interestingly, Ism1 was also useful to measure the "rejuvenated" age of fish Nothobranchius guentheri reversed by salidroside treatment and temperature reduction, providing additional evidence that Ism1 was an aging biomarker. In addition, we clearly showed that dietary intake of recombinant Ism1 had little effects on the body length and weight of aging N. guentheri, but it retarded the onset of age-related biomarkers and prolonged both the maximum and median lifespan of the fish. We also showed that Ism1 exerted its rejuvenation activity via the enhancement of antioxidant system. Collectively, our results indicate that Ism1 is not only is a novel biomarker of aging but also a potential rejuvenation factor capable of reversing aging of N. guentheri.
C1 [Li, Congjun; Song, Lili; Zhou, Yang; Zhang, Shicui] Ocean Univ China, Inst Evolut & Marine Biodivers, 5 Yushan Rd, Qingdao 266003, Peoples R China.
   [Li, Congjun; Song, Lili; Zhou, Yang; Zhang, Shicui] Ocean Univ China, Dept Marine Biol, 5 Yushan Rd, Qingdao 266003, Peoples R China.
   [Yuan, Jiangshui] Qingdao Municipal Hosp, Clin Lab, Qingdao 266011, Shandong, Peoples R China.
   [Zhang, Shicui] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266003, Peoples R China.
C3 Ocean University of China; Ocean University of China; Qingdao Municipal
   Hospital; Laoshan Laboratory
RP Zhang, SC (corresponding author), Ocean Univ China, Inst Evolut & Marine Biodivers, 5 Yushan Rd, Qingdao 266003, Peoples R China.; Zhang, SC (corresponding author), Ocean Univ China, Dept Marine Biol, 5 Yushan Rd, Qingdao 266003, Peoples R China.
EM sczhang@ouc.edu.cn
FU National Natural Science Foundation of China [32073000]; Marine S&T Fund
   of Shandong province for Pilot National Laboratory for Marine Science
   and Technology (Qingdao) [2018SDKJ0302-1]
FX This work was supported by the National Natural Science Foundation of
   China (Grant No: 32073000) and the Marine S&T Fund of Shandong province
   for Pilot National Laboratory for Marine Science and Technology
   (Qingdao) (Grant No: 2018SDKJ0302-1).
CR [Anonymous], 2017, World population projected to reach 9.8 billion in 2050
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NR 59
TC 16
Z9 18
U1 2
U2 13
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1389-5729
EI 1573-6768
J9 BIOGERONTOLOGY
JI Biogerontology
PD FEB
PY 2022
VL 23
IS 1
BP 99
EP 114
DI 10.1007/s10522-021-09948-5
EA JAN 2022
PG 16
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA ZK1QH
UT WOS:000739274800001
PM 34988750
DA 2026-05-27
ER

PT J
AU He, YF
   Liu, WL
   Su, R
   Xiu, Y
   Pei, J
AF He Yangfang
   Liu Wenlong
   Su Rui
   Xiu Yang
   Pei Jin
TI Detection of Saponins and Oligosaccharides in Herbs Using Direct
   Analysis in Real-time Mass Spectrometry
SO CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
LA English
DT Article
DE Saponin; Oligosaccharide; Direct analysis in real-time(DART);
   Methylation
ID ION-SOURCE; MS; GINSENG; CHROMATOGRAPHY; GINSENOSIDES; IONIZATION;
   ALKALOIDS; GLYCANS
AB The use of direct analysis in real-time(DART) mass spectrometry(MS) for direct detection of saponins and oligosaccharides is difficult mainly because of the strong polarity of these molecules, which results in challenges regarding desorption and ionization of the compounds. Structure derivatization, such as methylation, is essential for improving the volatility and the proton affinity of saponin and oligosaccharides. In this study, solid-phase methylation of saponins and oligosaccharides was accomplished in a stainless steel methylation column, and the methylated products of astragaloside, salidroside, icariin, ginsenosides(Rbl, Rb2, Rb3, Rd, Re, Rf and Rgl), maltose, isomaltose, sucrose and maltotriose were analyzed using DART-MS. Fragmentations occurred during ionization and tandem mass spectrometry, and most fragments corresponded to the glycosidic bond, cross-ring cleavages, and the neutral loss of CH3OH ions, but the aglycone cleavage fragment was not detected. Furthermore, the method was successfully used in the rapid and simultaneous analysis of saponins and oligosaccharides in a ginseng extract; quantitative analysis of ginsenoside Rbl was also carried out, and consistent content results were obtained in DART-MS and high-performance liquid chromatography(HPLC).
C1 [He Yangfang; Pei Jin] Jilin Univ, Sch Pharmaceutial Sci, Changchun 130021, Peoples R China.
   [Liu Wenlong; Su Rui; Xiu Yang] Changchun Univ Chinese Med, Jilin Ginseng Acad, Changchun 130117, Peoples R China.
   [He Yangfang] Jilin Univ, Hosp 2, Changchun 130041, Peoples R China.
C3 Jilin University; Changchun University of Chinese Medicine; Jilin
   University
RP Pei, J (corresponding author), Jilin Univ, Sch Pharmaceutial Sci, Changchun 130021, Peoples R China.
EM peijin1965@163.com
FU National Natural Science Foundation of China [21475012]
FX Supported by the National Natural Science Foundation of
   China(No.21475012).
CR Auyeung KK, 2016, AM J CHINESE MED, V44, P1, DOI 10.1142/S0192415X16500014
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NR 30
TC 12
Z9 13
U1 1
U2 68
PU HIGHER EDUCATION PRESS
PI BEIJING
PA CHAOYANG DIST, 4, HUIXINDONGJIE, FUSHENG BLDG, BEIJING 100029, PEOPLES R
   CHINA
SN 1005-9040
EI 2210-3171
J9 CHEM RES CHINESE U
JI Chem. Res. Chin. Univ.
PD APR
PY 2017
VL 33
IS 2
BP 172
EP 178
DI 10.1007/s40242-017-6297-5
PG 7
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA ES9HK
UT WOS:000399867100004
DA 2026-05-27
ER

PT J
AU Shi, XL
   Ma, JY
   Liu, W
   Shen, J
   Xu, GL
   Zhang, JW
   Liu, L
AF Shi, Xiaoli
   Ma, Jingya
   Liu, Wei
   Shen, Jie
   Xu, Guanglin
   Zhang, Jianwei
   Liu, Li
TI Pharmacokinetics Integrated With Network Pharmacology to Investigate the
   Potential Mechanism of Lu-Jiao Fang Inhibited Endothelial-to-Mesenchymal
   Transition in Pressure Overload-Induced Cardiac Fibrosis
SO BIOMEDICAL CHROMATOGRAPHY
LA English
DT Article
DE cardiac fibrosis; Lu-Jiao Fang; pharmacokinetics; pharmacology network;
   RXFP1 signaling
ID PATHWAY
AB The aim of this study was to investigate the potential mechanism of Lu-Jiao Fang (LJF) inhibiting endothelial-to-mesenchymal transition (EndMT) in pressure overload-induced cardiac fibrosis. Pharmacokinetic behaviors of the ingredients of LJF were evaluated by LC-MS/MS analysis. Then putative pathways by which LJF regulates EndMT were analyzed by network pharmacology and verified in transverse aortic constriction-induced cardiac fibrosis rats. Loganin, morroniside, salidroside, isopsoralen, and psoralen showed higher plasma, left and right ventricular Cmax and AUC0-t values than hesperidin, specnuezhenide, and icariside II. Twenty-four potential targets related to EndMT were identified, which were mainly involved in relaxin signaling pathway. AKT1, TP53, MMP9, HIF1A, Snail1, and MMP2 were key therapeutic targets in protein-protein interaction network. LJF reversed cardiac dysfunction, left ventricular dilation, and fibrosis and significantly downregulated collagen type I and III and EndMT regulators (Snail1 and Twist1) mRNA expression. In relaxin signaling pathway, the RXFP1 protein expression increased by 22.52%, and the protein phosphorylation of Smad2 and Smad3 decreased by 33.52% and 12.79%, in response to the treatment with LJF. This study initially revealed the EndMT inhibition effects and molecular mechanisms of LJF in cardiac fibrosis, providing a reference basis for the promotion of LJF in the clinic.
C1 [Shi, Xiaoli; Ma, Jingya; Liu, Wei; Shen, Jie; Xu, Guanglin; Zhang, Jianwei; Liu, Li] Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Dept Pharm, Shanghai, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine
RP Liu, L (corresponding author), Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Dept Pharm, Shanghai, Peoples R China.
EM lujiaofang_liu@126.com
OI shi, xiaoli/0000-0002-1597-0312
FU National Natural Science Foundation of China [82104429, 82104616,
   81573648]
FX This study was funded by the National Natural Science Foundation of
   China (Grant Numbers 82104429, 82104616 and 81573648).
CR Chen HH, 2017, BIOMED PHARMACOTHER, V95, P461, DOI 10.1016/j.biopha.2017.08.102
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NR 31
TC 0
Z9 0
U1 2
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0269-3879
EI 1099-0801
J9 BIOMED CHROMATOGR
JI Biomed. Chromatogr.
PD JAN 8
PY 2025
VL 39
IS 2
AR e6075
DI 10.1002/bmc.6075
PG 15
WC Biochemical Research Methods; Biochemistry & Molecular Biology;
   Chemistry, Analytical; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Pharmacology & Pharmacy
GA R4N2B
UT WOS:001391227300001
PM 39775935
DA 2026-05-27
ER

PT J
AU Wang, XS
   Zhang, JM
   Wang, PX
   Zhang, YL
   Yang, QY
   Zhang, ZC
   Ma, ZQ
   Wu, YF
   Ma, JY
   Fan, EG
AF Wang, Xinsheng
   Zhang, Jiameng
   Wang, Panxu
   Zhang, Yanlong
   Yang, Qinyu
   Zhang, Zichen
   Ma, Zhanqiang
   Wu, Yanfang
   Ma, Junying
   Fan, Enguo
TI Evaluation of alpha-glucosidase inhibition activity and glycosides in
   the Syringa pubescens Turcz from different geographical origin
SO SCIENTIA HORTICULTURAE
LA English
DT Article
DE Syringa pubescens Turcz; Simultaneous determination; &
   alpha;-glucosidase inhibitory activity; Glycosides
ID SECONDARY METABOLITES; MECHANISM; LEAVES
AB Inhibition of a-glucosidase is an attractive strategy for the control of hyperglycaemia. Naturally occurring bioactive compounds are potential sources of a-glucosidase inhibitors. The Syringa pubescens Turcz (SP) is commonly used as Chinese folk medicine for treatment of hepatitis and cirrhosis. However, the anti -hyperglycemic activity of SP was lack of study and the report on compounds of a-glucosidase inhibitory activity of SP was also insufficient. In this study, the a-glucosidase inhibitory activity of SP extract was firstly assessed in vitro. The quantification analysis of bioactive glycosides in SP collected at different geographical origins and its correlation with a-glucosidase inhibitory activities were investigated. As the results, six glycosides including salidroside, echinacoisde, forsythoside B, verbascoside, isoacteoside and oleuropein were simultaneously determined using HPLC-DAD method. Moreover, SP collected from different geographical origins exhibited different concentrations of bioactive glycosides and had potential a-glucosidase inhibitory activity. The results of correlation analysis indicated that the amounts of glycosides were positively correlated with the a-glucosidase inhibitory activities of SP. Then, the evaluation of a-glucosidase inhibitory activity of six glycosides was per-formed. And docking study was conducted to predict the possible binding sites of forsythoside B. Forsythoside B might be the most possible a-glucosidase inhibitor in SP.
C1 [Wang, Xinsheng; Zhang, Jiameng; Wang, Panxu; Zhang, Yanlong; Yang, Qinyu; Zhang, Zichen; Ma, Junying] Henan Univ Sci & Technol, Coll Chem & Chem Engn, Luoyang 471023, Peoples R China.
   [Ma, Zhanqiang] Henan Univ Sci & Technol, Coll Tree Peony, Luoyang 471023, Peoples R China.
   [Wu, Yanfang] Henan Univ Sci & Technol, Coll Basic Med Sci, Luoyang 471023, Peoples R China.
   [Fan, Enguo] Univ Freiburg, Inst Biochem & Mol Biol, Stefan Meier Str 17, D-79104 Freiburg, Germany.
C3 Henan University of Science & Technology; Henan University of Science &
   Technology; Henan University of Science & Technology; University of
   Freiburg
RP Wang, XS (corresponding author), Henan Univ Sci & Technol, Coll Chem & Chem Engn, Luoyang 471023, Peoples R China.
EM wxs501@gmail.com
OI wang, xinsheng/0000-0002-4962-5023
FU National Natural Science Foundation of China [U1804175, 202210464029,
   2022416]
FX This work was financially supported by the National Natural Science
   Foundation of China (U1804175) and Student Research Training Pro- gram
   (202210464029, 2022416) .
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TC 11
Z9 13
U1 1
U2 15
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0304-4238
EI 1879-1018
J9 SCI HORTIC-AMSTERDAM
JI Sci. Hortic.
PD OCT 1
PY 2023
VL 320
AR 112198
DI 10.1016/j.scienta.2023.112198
EA JUN 2023
PG 8
WC Horticulture
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture
GA L1CO6
UT WOS:001020706600001
DA 2026-05-27
ER

PT J
AU Hollá, V
   Karkeszová, K
   Antosová, M
   Polakovic, M
AF Holla, Veronika
   Karkeszova, Klaudia
   Antosova, Monika
   Polakovic, Milan
TI Transglycosylation properties of a Kluyveromyces lactis enzyme
   preparation: Production of tyrosol β-fructoside using free and
   immobilized enzyme
SO PROCESS BIOCHEMISTRY
LA English
DT Article
DE beta-fructofuranosidase; Kluyveromyces lactis; Transglycosylation;
   Tyrosol beta-fructoside; Immobilization; Deep eutectic solvents
ID DEEP EUTECTIC SOLVENTS; RHODIOLA-ROSEA L.; SALIDROSIDE; GALACTOSIDASE;
   GLUCOSIDASE; HYDROLYSIS; HYDROLASE; INSIGHTS; PROTEIN; LACTOSE
AB A variety of glycosides with interesting biological properties suitable for application in cosmetic and pharmaceutical industry can be found in nature. However, the demand exceeds the quantity and purity which can be obtained naturally and therefore enzymatic glycosylation has been of great interest in recent decades. In this study, crude Kluyveromyces lactis enzyme preparation Lactozym 3000 L was examined for the production of two phenolic glycosides - tyrosol beta-fructoside and tyrosol beta-galactoside. Its performance was compared to other commercial fungal and yeast enzyme preparations. It was found that the key enzyme, beta-galactosidase is un-suitable for tyrosol beta-galactoside production. However, one of the Lactozym 3000 L components, beta-fructofur-anosidase, performed very well in the tyrosol beta-fructoside production from sucrose and tyrosol. Lactozym 3000 L was effectively immobilized onto activated carrier Lifetech ECR8309 via covalent binding of the enzyme, which is a promising method to reduce very high enzyme consumption in its free form. Potential of deep-eutectic solvents to enhance transfructosylation selectivity has been studied proving their interesting stabilization effect on Lactozym 3000 L beta-fructofuranosidase.
C1 [Holla, Veronika; Karkeszova, Klaudia; Antosova, Monika; Polakovic, Milan] Slovak Univ Technol Bratislava, Fac Chem & Food Technol, Inst Chem & Environm Engn, Dept Chem & Biochem Engn, Radlinskeho 9, Bratislava 81237, Slovakia.
C3 Slovak University of Technology Bratislava
RP Polakovic, M (corresponding author), Slovak Univ Technol Bratislava, Fac Chem & Food Technol, Inst Chem & Environm Engn, Dept Chem & Biochem Engn, Radlinskeho 9, Bratislava 81237, Slovakia.
EM milan.polakovic@stuba.sk
RI Polakovic, Milan/A-1080-2015; Antosova, Monika/HFZ-9237-2022
OI Polakovic, Milan/0000-0003-0238-8996; Antosova,
   Monika/0000-0003-3671-9108
FU Slovak Research and Development Agency [APVV-18-0188]
FX This work was supported by a grant from the Slovak Research and
   Development Agency (Grant number: APVV-18-0188) . Ms. Alessandra Basso
   from Purolite company is acknowledged for kindly providing the
   immobilization carrier. Dr. Vladimir Mastihuba and dr. Elena Karnis?ova
   Potocka are kindly acknowledged for providing the
   tyrosol/3-D-galac-toside and tyrosol/3-D-fructoside standards.
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NR 44
TC 5
Z9 5
U1 1
U2 32
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1359-5113
EI 1873-3298
J9 PROCESS BIOCHEM
JI Process Biochem.
PD NOV
PY 2021
VL 110
BP 168
EP 175
DI 10.1016/j.procbio.2021.08.016
EA AUG 2021
PG 8
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Engineering
GA WA4ST
UT WOS:000702877400010
DA 2026-05-27
ER

PT J
AU Zhang, SJ
   Zhang, L
   Zhang, H
   Fan, GW
   Qiu, JW
   Fang, ZB
   Wu, HB
   Wang, Y
   Zhao, XP
AF Zhang, Shujing
   Zhang, Ling
   Zhang, Han
   Fan, Guanwei
   Qiu, Jiuwen
   Fang, Zongbao
   Wu, Haibo
   Wang, Yi
   Zhao, Xiaoping
TI Hongjingtian Injection Attenuates Myocardial Oxidative Damage via
   Promoting Autophagy and Inhibiting Apoptosis
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID ISCHEMIA/REPERFUSION INJURY; CELL-DEATH; SALIDROSIDE; PATHWAY;
   CROSSTALK; STRESS; EXTRACT; CANCER; ROLES
AB Natural products with antioxidative activities are widely applied to prevent and treat various oxidative stress related diseases, including ischemic heart disease. However, the cellular and molecular mechanisms of those therapies are still needed to be illustrated. In this study, we characterized the cardioprotective effects of Hongjingtian Injection (HJT), an extensively used botanical drug for treating coronary heart disease. The H/R-induced profound elevation of oxidative stress was suppressed by HJT. HJT also attenuates oxidative injury by promoting cell viability, intracellular ATP contents, and mitochondrial oxygen consumption. Validation experiments indicated that HJT inhibited H/R-induced apoptosis and regulated the expression of apoptosis-associated proteins Bcl-2 and cleaved caspase3. Interestingly, HJT significantly regulated the expression of autophagy-related proteins LC3, Beclin, and mTOR as well as ERK and AKT. We provide evidence that the mechanism involves activation of AKT/Beclin-1, AKT, and ERK/mTOR pathway in cardiomyocyte autophagy. Histological and physiological evaluation revealed that HJT significantly decreased the infarct area of the heart, improved cardiac function, and increased the expression of LC3B in a rat model of coronary occlusion. From the obtained data, we proposed that HJT diminished myocardial oxidative damage through regulating the balance of autophagy and apoptosis and reducing oxidative stress.
C1 [Zhang, Shujing; Wang, Yi] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China.
   [Zhang, Ling] Zhejiang Univ, Affiliated Hosp 2, Dept Cardiol, Coll Med, Hangzhou 310009, Zhejiang, Peoples R China.
   [Zhang, Han; Fan, Guanwei] Tianjin Univ Tradit Chinese Med, Key Lab Pharmacol Tradit Chinese Med Formulae, Minist Educ, Tianjin 300193, Peoples R China.
   [Qiu, Jiuwen; Fang, Zongbao; Wu, Haibo] Tonghua Yusheng Pharmaceut Co Ltd, Tonghua 134008, Peoples R China.
   [Zhao, Xiaoping] Zhejiang Chinese Med Univ, Coll Preclin Med, Hangzhou 310053, Zhejiang, Peoples R China.
C3 Zhejiang University; Zhejiang University; Tianjin University of
   Traditional Chinese Medicine; Zhejiang Chinese Medical University
RP Wang, Y (corresponding author), Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China.; Zhao, XP (corresponding author), Zhejiang Chinese Med Univ, Coll Preclin Med, Hangzhou 310053, Zhejiang, Peoples R China.
EM mysky@zju.edu.cn; zhaoxiaoping8686@sina.com
RI Wang, Yi/C-2871-2013; guanwei, fan/M-8193-2019; Zhao,
   xiaoping/ABE-3908-2020
OI Wang, Yi/0000-0002-3676-9183; Zhang, Shujing/0000-0001-6792-7386; 
FU Zhejiang Provincial Natural Science Foundation of China [LR16H280001];
   Fundamental Research Funds for the Central Universities [2017FZA7011,
   2017FZA7015]; Technology Project of Jilin Province [20170203005YY]
FX This work was supported by the grants from the Zhejiang Provincial
   Natural Science Foundation of China (no. LR16H280001), the Fundamental
   Research Funds for the Central Universities (nos. 2017FZA7011,
   2017FZA7015), and the Technology Project of Jilin Province
   (20170203005YY).
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NR 41
TC 10
Z9 14
U1 0
U2 31
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2017
VL 2017
AR 6965739
DI 10.1155/2017/6965739
PG 11
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA FC4MW
UT WOS:000406814900001
PM 28804535
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Landtag, J
   Baumert, A
   Degenkolb, T
   Schmidt, J
   Wray, V
   Scheel, D
   Strack, D
   Rosahl, S
AF Landtag, J
   Baumert, A
   Degenkolb, T
   Schmidt, J
   Wray, V
   Scheel, D
   Strack, D
   Rosahl, S
TI Accumulation of tyrosol glucoside in transgenic potato plants expressing
   a parsley tyrosine decarboxylase
SO PHYTOCHEMISTRY
LA English
DT Article
DE Solanum tuberosum; Solanaceae; pathogen response; salidroside
ID CELL-SUSPENSION CULTURES; TRYPTOPHAN DECARBOXYLASE; PROMOTER; GENES
AB As part of the response to pathogen infection, potato plants accumulate soluble and cell wall-bound phenolics such as hydroxycinnamic acid tyramine amides. Since incorporation of these compounds into the cell wall leads to a fortified barrier against pathogens, raising the amounts of hydroxycinnamic acid tyramine amides might positively affect the resistance response. To this end, we set out to increase the amount of tyramine, one of the substrates of the hydroxycinnamoyl-CoA:tyramine N-(hydroxycinnamoyl)-transferase reaction, by placing a cDNA encoding a pathogen-induced tyrosine decarboxylase from paisley under the control of the 35S promoter and introducing the construct into potato plants via Agrobacterium tumefaciens-mediated transformation. While no alterations were observed in the pattern and quantity of cell wall-bound phenolic compounds in transgenic plants, the soluble fraction contained several new compounds. The major one was isolated and identified as tyrosol glucoside by liquid chromatography-electrospray ionization-high resolution mass spectrometry and NMR analyses. Our results indicate that expression of a tyrosine decarboxylase in potato does not channel tyramine into the hydroxycinnamoyl-CoA:tyramine N-(hydroxycinnamoyl)-transferase reaction but rather unexpectedly, into a different pathway leading to the formation of a potential storage compound. (C) 2002 Elsevier Science Ltd. All rights reserved.
C1 Inst Plant Biochem, Dept Stress & Dev Biol, D-06120 Halle An Der Saale, Germany.
   Inst Plant Biochem, Dept Secondary Metab, D-06120 Halle An Der Saale, Germany.
   Inst Plant Biochem, Dept Bioorgan Chem, D-06120 Halle An Der Saale, Germany.
   German Res Ctr Biotechnol, D-38124 Braunschweig, Germany.
C3 Helmholtz Association; Helmholtz-Center for Infection Research
RP Rosahl, S (corresponding author), Inst Plant Biochem, Dept Stress & Dev Biol, Weinberg 3, D-06120 Halle An Der Saale, Germany.
EM srosahl@ipb-halle.de
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NR 22
TC 33
Z9 43
U1 1
U2 22
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9422
EI 1873-3700
J9 PHYTOCHEMISTRY
JI Phytochemistry
PD AUG
PY 2002
VL 60
IS 7
BP 683
EP 689
AR PII S0031-9422(02)00161-9
DI 10.1016/S0031-9422(02)00161-9
PG 7
WC Biochemistry & Molecular Biology; Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Biochemistry & Molecular Biology; Plant Sciences
GA 591JJ
UT WOS:000177875900003
PM 12127585
DA 2026-05-27
ER

PT J
AU Teng, GL
   Zhang, M
   Pan, YL
   Karampoor, S
   Mirzaei, R
AF Teng, Geling
   Zhang, Min
   Pan, Yuling
   Karampoor, Sajad
   Mirzaei, Rasoul
TI Modulating the tumor microenvironment: The role of traditional Chinese
   medicine in improving lung cancer treatment
SO OPEN LIFE SCIENCES
LA English
DT Review
DE lung cancer; TME; TCM; immunomodulation; apoptosis; metastasis: Side
   effect
ID CELLS IN-VITRO; EPITHELIAL-MESENCHYMAL TRANSITION; HISTONE DEACETYLASE
   INHIBITORS; ACTIVE INGREDIENTS; ANTITUMOR-ACTIVITY; INDUCED APOPTOSIS;
   PROSTATE-CANCER; DOWN-REGULATION; ORAL MUCOSITIS; DOUBLE-BLIND
AB The holistic approach of traditional Chinese medicine (TCM) has been increasingly being focused on as a potential adjuvant to conventional lung cancer therapies in an attempt at modulating the tumor microenvironment (TME). Covering a diverse range of herbal medicine, acupuncture, and dietary therapy, TCM brings a unique perspective to influencing the TME. Importantly, the study has found the effects of specific TCM compounds, such as cantharidin, boehmenan, shikonin, and salidroside, on lung cancer in the TME. These compounds interact intricately with key apoptotic regulators, oxidative stress pathways, and inflammation-related mechanisms, suggesting their potential role in enhancing conventional therapies. TCM compounds could modulate a variety of cellular and molecular pathways, potentially inhibiting tumor proliferation, invasion, and metastasis. Besides, the practices of TCM alleviate the side effects of conventional treatments and enhance immune function, hence promoting the quality of life among lung cancer patients. In this regard, this review gives a contemporary account of the state of affairs on the part of TCM within the framework of the treatment of lung cancer with reference to its recent developments, and diverse roles.
C1 [Teng, Geling] Shandong Univ, Shandong Publ Hlth Clin Ctr, Dept Resp & Crit Care Med, Jinan 250013, Peoples R China.
   [Zhang, Min] Shandong First Med Univ, Shandong Prov Hosp, Dept Resp & Crit Care Med, Jinan 250021, Peoples R China.
   [Pan, Yuling] Shandong Univ Tradit Chinese Med, Sch Med, Jinan 250355, Peoples R China.
   [Karampoor, Sajad] Iran Univ Med Sci, Gastrointestinal & Liver Dis Res Ctr, Tehran, Iran.
   [Mirzaei, Rasoul] Novinsin Biotechnol Inc, Tehran, Iran.
C3 Shandong University; Shandong First Medical University & Shandong
   Academy of Medical Sciences; Shandong University of Traditional Chinese
   Medicine; Iran University of Medical Sciences
RP Pan, YL (corresponding author), Shandong Univ Tradit Chinese Med, Sch Med, Jinan 250355, Peoples R China.
EM panyuling1980@sina.com
RI Karampoor, Sajad/AAY-7072-2021
CR Almeida V, 2023, HEALTHCARE-BASEL, V11, DOI 10.3390/healthcare11192621
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NR 238
TC 2
Z9 2
U1 11
U2 23
PU DE GRUYTER POLAND SP Z O O
PI WARSAW
PA BOGUMILA ZUGA 32A STR, 01-811 WARSAW, MAZOVIA, POLAND
SN 2391-5412
J9 OPEN LIFE SCI
JI Open Life Sci.
PD MAY 20
PY 2025
VL 20
IS 1
AR 20251100
DI 10.1515/biol-2025-1100
PG 28
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA 2YR5D
UT WOS:001494468900001
PM 40417000
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU García, P
   Romero, C
   Brenes, M
AF Garcia, P.
   Romero, C.
   Brenes, M.
TI Bioactive substances in black ripe olives produced in Spain and the USA
SO JOURNAL OF FOOD COMPOSITION AND ANALYSIS
LA English
DT Article
DE Food analysis; Food composition; Table olives; Phenolic; Oleanolic;
   Maslinic; Hydroxytyrosol; Bioactive
ID PHENOLIC-COMPOUNDS; TABLE OLIVES; ANTIOXIDANT ACTIVITY; QUALITY; OIL;
   PRESERVATION; POLYPHENOLS; OLEUROPEIN; ACIDS
AB The aim of this work was to assess the contents of phenolic and triterpenic substances in commercial olives produced in the USA and Spain, which currently use different olive cultivars and elaboration methods The phenolic compounds identified in black ripe olives were hydroxytyrosol, hydroxytyrosol-4-glucoside, hydroxytyrosol acetylated, salidroside, tyrosol, luteolin-7-glucoside, p-coumaric acid and comselogoside. The concentration of these substances in American black ripe olives was lower than 50 mg/kg whereas it was higher than 150 mg/kg in Spanish olives regardless of whether the American processors used the Manzanilla cultivar, which contains higher contents of these substances in the harvested fruit than the Hojiblanca cultivar. Moreover, the concentration of triterpenic acids (oleanolic and maslinic) in American black ripe olives was lower than 200 mg/kg whereas it was higher than 400 mg/kg in the Spanish product. These results indicate that the method used by American processors to elaborate black ripe olives gives rise to lower contents in bioactive substances than the Spanish method, and it must be related to the number of alkali/washing cycles used during processing. Hence, olive processors worldwide must keep in mind the increasing consumer demand for healthy products rich in bioactive substances when developing their elaboration methods.
C1 [Garcia, P.; Romero, C.; Brenes, M.] CSIC, IG, Campus Univ Pablo de Olavide,Ctra Utrera Km 1, Seville 41013, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto
   de la Grasa (IG)
RP Brenes, M (corresponding author), CSIC, IG, Campus Univ Pablo de Olavide,Ctra Utrera Km 1, Seville 41013, Spain.
EM brenes@ig.csic.es
RI Romero, Concepcion/F-2268-2016; García-García, Peo/F-3307-2016;
   /F-4603-2016
OI Romero, Concepcion/0000-0003-1885-1770; García-García,
   Peo/0000-0002-4842-5142; 
FU European Union FEDER funds;  [AGL-2013-42739-R]
FX This work was partially supported by the Project AGL-2013-42739-R and
   the European Union FEDER funds.
CR Alexandraki V, 2014, LWT-FOOD SCI TECHNOL, V58, P609, DOI 10.1016/j.lwt.2014.04.005
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NR 31
TC 19
Z9 19
U1 0
U2 23
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1575
EI 1096-0481
J9 J FOOD COMPOS ANAL
JI J. Food Compos. Anal.
PD MAR
PY 2018
VL 66
BP 193
EP 198
DI 10.1016/j.jfca.2017.12.022
PG 6
WC Chemistry, Applied; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Food Science & Technology
GA FV6XB
UT WOS:000424724300025
DA 2026-05-27
ER

PT J
AU Carlucci, V
   Ponticelli, M
   Russo, D
   Labanca, F
   Costantino, V
   Esposito, G
   Milella, L
AF Carlucci, Vittorio
   Ponticelli, Maria
   Russo, Daniela
   Labanca, Fabiana
   Costantino, Valeria
   Esposito, Germana
   Milella, Luigi
TI Nutraceutical Valorization of Exhausted Olive Pomace from Olea
   europaea L. Using Advanced Extraction Techniques
SO PLANTS-BASEL
LA English
DT Article
DE Olea europaea L.; by-products; olive pomace; green chemistry;
   nutraceuticals; circular economy
ID PHENOLIC-COMPOUNDS; ANTIOXIDANT ACTIVITY; SOLVENTS; BIOMASS; PROFILE;
   OIL
AB Exhausted olive pomace (EOP) represents the principal residue of olive pomace. Several studies have optimized the extraction of specialized metabolites from the EOP of Olea europaea L., but a comparison between different extractive methods has not been made. For this reason, the present investigation aims to compare four different extractive methods by using water and 15% ethanol/water as extractive solvents. Specifically, based on extract antioxidant activity, the methods compared were maceration (MAC), microwave-assisted extraction (MAE), ultrasound-assisted extraction (UAE), and Accelerated Solvent Extraction (ASE). Between these, the UAE and ASE hydroalcoholic EOP extracts were demonstrated to have the highest antioxidant activity. Subsequently, these extracts were investigated for their hypoglycemic and antiradical activity using in vitro cell-free and cell-based assays, respectively. ASE hydroalcoholic EOP extract demonstrated the greatest ability to inhibit the alpha-amylase enzyme and an in vitro antioxidant activity comparable to N-acetyl cysteine in HepG2 cells. UAE and ASE extracts' phytochemical characterization was also performed, identifying seven phenolic compounds, including 3-hydroxytyrosol, tyrosol, and, for the first time, salidroside. The ASE hydroalcoholic EOP extract was the richest from a phytochemical point of view, thus confirming its major biological activity. Therefore, ASE and 15% ethanol/water may represent the best extractive method for EOP nutraceutical valorization.
C1 [Carlucci, Vittorio; Ponticelli, Maria; Russo, Daniela; Labanca, Fabiana; Milella, Luigi] Univ Basilicata, Dept Sci, Via Ateneo Lucano 10, I-85100 Potenza, Italy.
   [Ponticelli, Maria] Bulgarian Acad Sci BAS, Inst Mol Biol Roumen Tsanev, Dept Biochem Pharmacol & Drug Design, Acad G Bonchev Str,Bl 21, Sofia 1113, Bulgaria.
   [Russo, Daniela] BioActiPlant Srl, Viale Ateneo Lucano 10, I-85100 Potenza, Italy.
   [Costantino, Valeria; Esposito, Germana] Univ Naples Federico II, Dept Pharm, Blue Chem Lab Grp, I-80131 Naples, Italy.
C3 University of Basilicata; Italfarmaco; Bulgarian Academy of Sciences;
   University of Naples Federico II
RP Milella, L (corresponding author), Univ Basilicata, Dept Sci, Via Ateneo Lucano 10, I-85100 Potenza, Italy.; Esposito, G (corresponding author), Univ Naples Federico II, Dept Pharm, Blue Chem Lab Grp, I-80131 Naples, Italy.
EM vittorio.carlucci@unibas.it; maria.ponticelli@unibas.it;
   daniela.russo@unibas.it; valeria.costantino@unina.it;
   germana.esposito@unina.it; luigi.milella@unibas.it
RI ; Costantino, Valeria/AAN-1960-2020; CARLUCCI, VITTORIO/LXV-0373-2024;
   ESPOSITO, Germana/ABF-6241-2020; Milella, Luigi/AAA-4431-2021; russo,
   daniela/ABC-4318-2021
OI Ponticelli, Maria/0000-0002-2145-0284; Costantino,
   Valeria/0000-0001-8723-9505; CARLUCCI, VITTORIO/0009-0002-3954-0170;
   ESPOSITO, Germana/0000-0001-9619-7511; Milella,
   Luigi/0000-0002-5874-1237; Labanca, Fabiana/0000-0003-1197-8402; russo,
   daniela/0000-0002-3086-784X
FU Regione Basilicata; PSR Basilicata [degrees 312/17 CUP:
   C31G18000210002]; Italian Ministry of Economic Development
   [F/200099/01-03/X45];  [G49J19001350004];  [527/2019]
FX This research was funded by the following: Regione Basilicata; Project
   SPIA-Valorization of by-products from the agro-food chain CUP:
   G49J19001350004; DGR n. 527/2019 "PO FESR BASILICATA 2014-2020-Axis
   I-Research, Innovation Action, and Technological Development-Action
   1B.1.2.1-Avviso Pubblico per il sostegno alla creazione e sviluppo dei
   Cluster Tecnologici della Regione Basilicata e alla realizzazione di
   progetti di Ricerca e Sviluppo"; Project ALIMINTEGRA, GO NUTRIBAS
   financed on 16.1 by PSR Basilicata funding ex D.G.R. n degrees 312/17
   CUP: C31G18000210002; Italian Ministry of Economic Development "Fondo
   per la Crescita Sostenibile-Sportello "Agrifood" PON I&C 2014-2020",
   Project n. F/200099/01-03/X45.
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NR 35
TC 7
Z9 8
U1 3
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2223-7747
J9 PLANTS-BASEL
JI Plants-Basel
PD AUG
PY 2024
VL 13
IS 16
AR 2310
DI 10.3390/plants13162310
PG 15
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences
GA F0P2V
UT WOS:001306920400001
PM 39204746
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Yao, YJ
   Gao, XM
   Guo, MY
   Liu, JQ
   Kang, MH
AF Yao, Yingjun
   Gao, Xuemeng
   Guo, Mengyun
   Liu, Jianquan
   Kang, Minghui
TI The key tyrosine decarboxylase gene and its negative transcription
   factor for GX-50 biosynthesis in Sichuan Pepper (Zanthoxylum
   armatum)
SO INDUSTRIAL CROPS AND PRODUCTS
LA English
DT Article
DE Zanthoxylum armatum; TyDC genes family; ZaTyDC14; Decarboxylation;
   Expression regulation; GX-50
ID MOUSE MODEL; IN-VITRO; EXPRESSION; PATHWAY; SALIDROSIDE; DATABASE
AB The natural chemical N-[2-(3,4-methoxyphenyl)ethyl]-3-phenylacrylamide (GX-50) found in Sichuan pepper (Zanthoxylum armatum) is well known for its important applications in anti-aging and the treatment of various diseases. However, the functional tyrosine decarboxylase (TyDC) gene, which plays a pivotal role as the initial key enzyme in the biosynthetic pathway of GX-50 by catalyzing the decarboxylation of tyrosine to tyramine, has yet to be identified. We identified 19 potential TyDC genes from the Z. armatum genome. Among them, ZaTyDC14 showed the highest expression level in the husks than others, suggesting its critical role involved in GX-50 biosynthesis in this tissue. Through transient transformation of tobacco leaves and prokaryotic expression experiments, we confirmed that ZaTyDC14 catalyzed the conversion of tyrosine to tyramine. Overexpression of ZaTyDC14 reduced malondialdehyde (MDA) content, indicate of its critical role in this chemical reaction. Furthermore, our study found that the Zinc-finger protein (ZFP) binds directly to the ZaTyDC14 promoter, inhibiting its expression. Collectively, the present studies reveal the major gene involved in the decarboxylation of tyrosine during GX-50 synthesis in Sichuan pepper, as well as the probable negative regulator influencing its expression.
C1 [Yao, Yingjun; Gao, Xuemeng; Guo, Mengyun; Liu, Jianquan; Kang, Minghui] Sichuan Univ, Coll Life Sci, Key Lab Bioresource & Ecoenvironm, Minist Educ, Chengdu 610065, Peoples R China.
   [Liu, Jianquan; Kang, Minghui] Lanzhou Univ, Coll Ecol, State Key Lab Herbage Improvement & Grassland Agro, Lanzhou 730000, Peoples R China.
C3 Sichuan University; Lanzhou University
RP Liu, JQ; Kang, MH (corresponding author), Sichuan Univ, Coll Life Sci, Key Lab Bioresource & Ecoenvironm, Minist Educ, Chengdu 610065, Peoples R China.; Liu, JQ; Kang, MH (corresponding author), Lanzhou Univ, Coll Ecol, State Key Lab Herbage Improvement & Grassland Agro, Lanzhou 730000, Peoples R China.
EM liujq@nwipb.cas.cn; kangminghui0106@gmail.com
RI Kang, Minghui/JRX-5925-2023
OI Kang, Minghui/0000-0003-3192-5068
FU Second Tibetan Plateau Scientific Expedition and Research Program
   [2019QZKK0502]
FX This work was supported by the Second Tibetan Plateau Scientific
   Expedition and Research Program (2019QZKK0502) .
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NR 43
TC 1
Z9 1
U1 6
U2 25
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0926-6690
EI 1872-633X
J9 IND CROP PROD
JI Ind. Crop. Prod.
PD APR
PY 2024
VL 210
AR 118128
DI 10.1016/j.indcrop.2024.118128
EA JAN 2024
PG 12
WC Agricultural Engineering; Agronomy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture
GA JN7X8
UT WOS:001173924100001
DA 2026-05-27
ER

PT J
AU Chen, DL
   Qu, ZP
   Yang, SJ
   Li, YJ
   Yu, SX
   Li, X
   Lu, YT
   Yang, AD
   Liu, CJ
   Wu, SB
   Qiao, JJ
AF Chen, Danlei
   Qu, Zheping
   Yang, Shujuan
   Li, Yujie
   Yu, Shuxuan
   Li, Xin
   Lu, Yutong
   Yang, Aidong
   Liu, Chunjiang
   Wu, Shengbo
   Qiao, Jianjun
TI Quorum sensing regulating the productivity and stability of
   cross-feeding cocultivation
SO CHEMICAL ENGINEERING JOURNAL
LA English
DT Article
DE Quorum sensing; Dynamic metabolic control; Synthetic microbial
   consortia; Genome-scale metabolic models; Cross-feeding fermentation;
   Systems biology
ID METABOLIC FLUX; COMMUNITIES
AB Quorum sensing (QS), a dynamic microbial communication mechanism, has been widely applied to synthetic biology for different functions. The incorporation of genome-scale models (GEMs) provides a powerful tool for understanding the metabolic capabilities and interactions within microbial communities. However, the introduction of the relevant QS devices for the stability and productivity of the microbial community lacks systematic analysis, let alone the GEMs-based rational design and optimization of QS-regulated microbial ecosystems. In this study, we integrated different QS regulation strategies with the metabolic division of labor to establish a combinational GEM for systematically designing and optimizing the process of the two-strain cross-feeding cocultivation. Specifically, taking the production of salidroside within two cross-feeding fermentation as an example, the GEMs were developed for the static and QS-based dynamic regulation strategies, and the corresponding simulation and optimization were performed. Then, we further constructed the QS-based self-regulating, cross-regulating, and hybrid-regulating QS communication network (QSCN) by using synthetic biology toolkits to investigate the productivity and stability of cross-feeding cocultivation. Results showed that the hybrid QSCN can better realize the cell density control and the improvement of productivity (562.57 mg/L). This study offers insights for developing more comprehensive model and regulation strategies for QS-based control in diverse applications.
C1 [Chen, Danlei; Qu, Zheping; Yang, Shujuan; Li, Yujie; Yu, Shuxuan; Li, Xin; Liu, Chunjiang; Wu, Shengbo; Qiao, Jianjun] Tianjin Univ, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China.
   [Chen, Danlei; Lu, Yutong; Liu, Chunjiang; Wu, Shengbo; Qiao, Jianjun] Tianjin Univ, Zhejiang Inst, Shaoxing 312300, Peoples R China.
   [Yang, Aidong] Univ Oxford, Dept Engn Sci, Oxford OX1 3PJ, England.
   [Qiao, Jianjun] Tianjin Univ, Key Lab Syst Bioengn, Minist Educ, Tianjin 300072, Peoples R China.
   [Qiao, Jianjun] Tianjin Univ, Frontiers Sci Ctr Synthet Biol, Minist Educ, Tianjin 300072, Peoples R China.
C3 Tianjin University; Tianjin University; University of Oxford; Tianjin
   University; Tianjin University
RP Wu, SB; Qiao, JJ (corresponding author), Tianjin Univ, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China.
EM wushengbo@tju.edu.cn; jianjunq@tju.edu.cn
RI Yang, Aidong/M-2887-2013; Wu, Shengbo/GRK-0088-2022; lu,
   tong/HFZ-8889-2022
FU China Postdoctoral Science Foundation [2023M732599]; National Natural
   Science Foundation of China [32070073]; National Key Research and
   Develop-ment Program of China [2020YFA0907900, 2019YFA0905600]; Funds
   for Creative Research Groups of China [21621004]
FX The present study was supported by grants from China Postdoctoral
   Science Foundation (2023M732599) , the National Natural Science
   Foundation of China (32070073) , National Key Research and Develop-ment
   Program of China (No. 2020YFA0907900, 2019YFA0905600) , and the Funds
   for Creative Research Groups of China (21621004) .
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NR 56
TC 12
Z9 13
U1 14
U2 63
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 1385-8947
EI 1873-3212
J9 CHEM ENG J
JI Chem. Eng. J.
PD DEC 15
PY 2024
VL 502
AR 158167
DI 10.1016/j.cej.2024.158167
EA DEC 2024
PG 12
WC Engineering, Environmental; Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering
GA P6H7Y
UT WOS:001378902900001
DA 2026-05-27
ER

PT J
AU Zhumagul, M
   Raseta, M
   Miskovic, J
   Myrzagalieva, AB
   Kurmanbayeva, M
   Gafforov, Y
   Kubentayev, SA
   Kobylina, T
   Shaikhymbekova, R
   Kusmangazinov, A
AF Zhumagul, Moldir
   Raseta, Milena
   Miskovic, Jovana
   Myrzagalieva, Anar B.
   Kurmanbayeva, Meruyert
   Gafforov, Yusufjon
   Kubentayev, Serik A.
   Kobylina, Tatyana
   Shaikhymbekova, Raushan
   Kusmangazinov, Adil
TI PHARMACOLOGICAL EVALUATION OF RHODIOLA ROSEA L. EXTRACT FROM THE
   KAZAKH ECOSYSTEM: IMPLICATIONS FOR OBESITY MANAGEMENT IN MALE RATS
SO FARMACIA
LA English
DT Article
DE lipids; medicinal plant; obesity; Rhodiola rosea
ID INSULIN-RESISTANCE; CONSTITUENTS; SALIDROSIDE; ALKALOIDS; MECHANISM;
   MODEL
AB The aim of the study was to conduct a comprehensive assessment of the pharmacotherapeutic effect of the extract R. rose a in obesity including GC-MS analysis, biochemical analysis of blood serum and open field test were also conducted. The purebred 3-month-old white male laboratory rats were divided into three groups, control and two experimental groups with alimentary obesity with and without R. rose a treatment and fed with a low-calorie diet. Body weight decreased significantly with concomitant administration of R. rose a extract in the third group, whereas active weight loss was observed from 263.39 +/- 10.80 g on day 25 to 213.34 +/- 8.74 g on day 30. Treatment with R. rose a extract reduced total body weight, abdominal fat mass, and lipids. The character of the pathological process was established in the rats with obesity after the application of R. rosea normalized the rats' liver enzyme levels. The open field test showed that the rats treated with R. rose a extract had a pronounced resistance of the nervous system and a moderate level of autonomic and emotional behaviour. The obtained results suggest that R. rosea extract should be used against obesity due to its anti-adipogenic properties.
C1 [Zhumagul, Moldir; Kurmanbayeva, Meruyert; Kobylina, Tatyana; Kusmangazinov, Adil] Dept Al Farabi Kazakh Natl Univ, Al Farabi Ave 71-19, Alma Ata 050060, Kazakhstan.
   [Zhumagul, Moldir; Kubentayev, Serik A.] Republican State Enterprise Right Econ Management, Astana Bot Garden Branch, Orynbor 16, Astana 010016, Kazakhstan.
   [Zhumagul, Moldir; Myrzagalieva, Anar B.] Astana Int Univ, Qabanbay Batyr Ave 8, Astana 020000, Kazakhstan.
   [Raseta, Milena] Univ Novi Sad, Fac Sci, Dept Chem Biochem & Environm Protect, Trg Dositeja Obradovica 3, Novi Sad 21000, Serbia.
   [Miskovic, Jovana] Univ Novi Sad, Fac Sci, Dept Biol & Ecol, Trg Dositeja Obradovica 2, Novi Sad 21000, Serbia.
   [Gafforov, Yusufjon] New Uzbekistan Univ, 54 Mustaqill Ave, Tashkent 100007, Uzbekistan.
   [Gafforov, Yusufjon] Cent Asian Univ, Tashkent 111221, Uzbekistan.
   [Gafforov, Yusufjon] Acad Sci Uzbek, Inst Bot, 32 Durmon Yuli, Tashkent 100125, Uzbekistan.
   [Kobylina, Tatyana] Inst Genet & Physiol, Prospect Al Farabi, 93 Bostandyk Dist,A15E3K2, Alma Ata 050060, Kazakhstan.
   [Shaikhymbekova, Raushan] Asfendiyarov Kazakh Natl Med Univ, Tole By 94, Alma Ata 050012, Kazakhstan.
C3 University of Novi Sad; University of Novi Sad; Central Asian
   University; Academy of Sciences of Uzbekistan; Institute of Botany,
   Uzbekistan; Asfendiyarov Kazakh National Medical University
RP Zhumagul, M (corresponding author), Dept Al Farabi Kazakh Natl Univ, Al Farabi Ave 71-19, Alma Ata 050060, Kazakhstan.; Zhumagul, M (corresponding author), Republican State Enterprise Right Econ Management, Astana Bot Garden Branch, Orynbor 16, Astana 010016, Kazakhstan.; Zhumagul, M (corresponding author), Astana Int Univ, Qabanbay Batyr Ave 8, Astana 020000, Kazakhstan.
EM mzhakypzhan@mail.ru
RI Gafforov, Yusufjon/C-5507-2015; Miskovic, Jovana/PHF-6039-2026;
   Kusmangazinov, Adil/ABD-6266-2021; Kurmanbayeva, Meruyert/O-1562-2016;
   Moldir, Zhumagul/ABE-9585-2021
OI Kobylina, Tatyana/0000-0003-2174-4140
FU Ministry of Education and Science of the Republic of Kazakhstan
   [AP19680461]
FX Acknowledgement This research was funded by grants from the Ministry of
   Education and Science of the Republic of Kazakhstan (No. AP19680461) .
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NR 62
TC 0
Z9 0
U1 0
U2 7
PU SOC STIINTE FARMACEUTICE ROMANIA
PI BUCURESTI
PA BUCURESTI, STR TRAIAN VUIA 6, SECT 1, BUCURESTI, 020956, ROMANIA
SN 0014-8237
EI 2065-0019
J9 FARMACIA
JI Farmacia
PD JAN-FEB
PY 2024
VL 72
IS 1
DI 10.31925/farmacia.2024.1.10
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA KJ7Q7
UT WOS:001179662100025
OA gold
DA 2026-05-27
ER

PT J
AU Stavrianidi, AN
   Baygildiev, TM
   Stekolshchikova, EA
   Shpigun, OA
   Rodin, IA
AF Stavrianidi, A. N.
   Baygildiev, T. M.
   Stekolshchikova, E. A.
   Shpigun, O. A.
   Rodin, I. A.
TI New Approaches to the Determination and Group Identification of
   Physiologically Active Compounds in Plant Materials and Commercial
   Products by High-Performance Liquid Chromatography-Mass Spectrometry
SO JOURNAL OF ANALYTICAL CHEMISTRY
LA English
DT Review
DE physiologically active components of plants; high-performance liquid
   chromatography with mass spectrometric detection; target analysis; group
   identification; quantitative analysis of a multicomponent system
ID GLYCYRRHIZA-URALENSIS FISCH; QUANTITATIVE-ANALYSIS; GLYCYRRHETINIC ACID;
   CHEMICAL-ANALYSIS; GINSENG; EXTRACTS; SAPONINS; MULTICOMPONENT;
   PROTODIOSCIN; GINSENOSIDES
AB An overview of methods for the target determination of physiologically active components of various plants: rosavin, rosarin, and salidroside from Rhodiola rosea; ginsenosides Rb1, Rg1, Rf, and Re from the Asian ginseng Panax ginseng, pseudoginsenosides F11 and RT5 from American ginseng Panax quinquefolius; schizandrols A and B from Schisandra chinensis seeds; bai?alin, baicalein, wogonin, and scutellarin from the root of the Baical skullcap Scutellariae baicalensis; and glycyrrhizin from the licorice Glycyrrhiza glabra root is presented. Methods for the individual and group identification of a wide range of saponins contained in plants of the genus Panax, leaves of the prayer leaf Abrus precatorius L., and licorice Glycyrrhiza glabra are also considered. Methods for estimating the amount of protodioscin, dioscin, and diosgenin in the aerial parts of Tribulus terrestris and a wide range of ginsenosides in various ginseng based products using the approaches to the quantitative analysis of a multicomponent system are reviewed. The developed methods are simple and reliable; they are original and can be used to control the quality of a wide range of plant products.
C1 [Stavrianidi, A. N.; Baygildiev, T. M.; Stekolshchikova, E. A.; Shpigun, O. A.; Rodin, I. A.] Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119991, Russia.
C3 Lomonosov Moscow State University
RP Stavrianidi, AN (corresponding author), Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119991, Russia.
EM stavrianidi.andrey@analyt.chem.msu.ru
RI Stavrianidi, Andrey/P-1736-2017; Stekolshchikova, Elena/U-1735-2018;
   Rodin, Igor A/M-3359-2016; Baygildiev, Timur/AAZ-4718-2020
OI Stekolshchikova, Elena/0000-0001-8607-9773; Rodin, Igor
   A/0000-0002-0588-6870; Baygildiev, Timur/0000-0003-2351-8403
FU Russian Science Foundation [17-13-01146]; Russian Science Foundation
   [17-13-01146] Funding Source: Russian Science Foundation
FX This work was supported by Russian Science Foundation (grant no.
   17-13-01146) for Moscow State University.
CR [Anonymous], BOTANIKO FARMAKOGNOS
   [Anonymous], ANALITIKA KONTROL
   [Anonymous], 2010, Pharmacopoeia of the People's Republic of China
   [Anonymous], EUR SCI COOP PHYT MO
   [Anonymous], CLIN GUIDE CHINESE H
   [Anonymous], MASS SPEKTROM
   [Anonymous], KHIM RASTIT SYRYA
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NR 40
TC 1
Z9 2
U1 0
U2 52
PU PLEIADES PUBLISHING LTD
PI TORTOLA
PA TROPIC ISLE BLDG, PO BOX 3331. ROAD TOWN, TORTOLA, BRITISH VIRGIN ISL
SN 1061-9348
EI 1608-3199
J9 J ANAL CHEM+
JI J. Anal. Chem.
PD JAN
PY 2019
VL 74
IS 1
BP 58
EP 70
DI 10.1134/S1061934819010106
PG 13
WC Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA HR4LM
UT WOS:000463117500006
DA 2026-05-27
ER

PT J
AU Liu, H
   Zhang, ZQ
   Xu, M
   Xu, R
   Wang, ZC
   Di, GF
AF Liu, Hua
   Zhang, Zhiqing
   Xu, Min
   Xu, Rong
   Wang, Zhichun
   Di, Guangfu
TI K6PC-5 Activates SphK1-Nrf2 Signaling to Protect Neuronal Cells from
   Oxygen Glucose Deprivation/Re-Oxygenation
SO CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Neuron; K6PC-5; SphK1; Nrf2; Oxidative stress
ID MITOCHONDRIAL PERMEABILITY TRANSITION; OXIDATIVE STRESS; CYCLOPHILIN-D;
   APOPTOSIS; PORE; SPHINGOSINE-KINASE-1; SALIDROSIDE; INHIBITION;
   ONCOGENE; CERAMIDE
AB Background/Aims: New strategies are required to combat neuronal ischemia-reperfusion injuries. K6PC-5 is a novel sphingosine kinase 1 (SphK1) activator whose potential activity in neuronal cells has not yet been tested. Methods: Cell survival and necrosis were assessed with a Cell Counting Kit-8 assay and lactate dehydrogenase release assay, respectively. Mitochondrial depolarization was tested by a JC-1 dye assay. Expression levels of nuclear factor erythroid 2-related factor 2 (Nrf2) signaling components were examined by quantitative real-timePCR and western blotting. Results: K6PC-5 protected SH-SY5Y neuronal cells and primary murine hippocampal neurons from oxygen glucose deprivation/re-oxygenation (OGDR). K6PC5 activated SphK1, and SphK1 knockdown by targeted short hairpin RNA (shRNA) almost completely abolished K6PC-5-induced neuronal cell protection. Further work showed that K6PC-5 inhibited OGDR-induced programmed necrosis in neuronal cells. Importantly, K6PC5 activated Nrf2 signaling, which is downstream of SphK1. Silencing of Nrf2 by targeted shRNA almost completely nullified K6PC-5-mediated neuronal cell protection against OGDR. Conclusion: K6PC-5 activates SphK1-Nrf2 signaling to protect neuronal cells from OGDR. K6PC-5 might be a promising neuroprotective strategy for ischemia-reperfusion injuries. (C) 2018 The Author(s) Published by S. Karger AG, Basel.
C1 [Liu, Hua] Jiangsu Univ, Peoples Hosp Kunshan 1, Dept Neurosurg, Suzhou, Peoples R China.
   [Zhang, Zhiqing] Soochow Univ, Inst Neurosci, Suzhou, Peoples R China.
   [Xu, Min] Kunshan Affiliated Hosp, Kunshan Hosp Tradit Chinese Med, Dept Neurosurg, Suzhou, Peoples R China.
   [Xu, Rong] Jiangsu Univ, Peoples Hosp Kunshan 1, Dept Pediat Surg, Suzhou, Peoples R China.
   [Wang, Zhichun; Di, Guangfu] Yijishan Hosp, Wannan Med Coll, Dept Neurosurg, 92Zheshan Rd, Wuhu 241001, Anhui, Peoples R China.
C3 Jiangsu University; Soochow University - China; Jiangsu University;
   Wannan Medical College
RP Di, GF (corresponding author), Yijishan Hosp, Wannan Med Coll, Dept Neurosurg, 92Zheshan Rd, Wuhu 241001, Anhui, Peoples R China.
EM wuhusjwk@163.com
RI Xu, Min/N-6142-2018
FU Clinical and Basic Researches of Brain Disease [KYC004]; National
   Natural Science Foundation of China [81502162]; Science Foundation of
   Wannan Medical College [WK2017F04]; Kunshan Science Project [KS1644]
FX This study was supported by Clinical and Basic Researches of Brain
   Disease (KYC004), the National Natural Science Foundation of China
   (81502162), the Science Foundation of Wannan Medical College (WK2017F04)
   and Kunshan Science Project (KS1644).
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NR 42
TC 27
Z9 28
U1 0
U2 4
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1015-8987
EI 1421-9778
J9 CELL PHYSIOL BIOCHEM
JI Cell. Physiol. Biochem.
PY 2018
VL 51
IS 4
BP 1908
EP 1920
DI 10.1159/000495716
PG 13
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA HF3WQ
UT WOS:000454165600028
PM 30504702
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Bai, NS
   He, K
   Ibarra, A
   Bily, A
   Roller, M
   Chen, XZ
   Rühl, R
AF Bai, Naisheng
   He, Kan
   Ibarra, Alvin
   Bily, Antoine
   Roller, Marc
   Chen, Xiaozhuo
   Ruehl, Ralph
TI Iridoids from Fraxinus excelsior with Adipocyte
   Differentiation-Inhibitory and PPARα Activation Activity
SO JOURNAL OF NATURAL PRODUCTS
LA English
DT Article
ID SECOIRIDOID GLUCOSIDES; MECHANISMS; GLYCOSIDE; DISEASES; OLEOSIDE; L.
AB Two new secoiridoid glucosides, excelsides A (1) and B (2), were isolated from the seeds of Fraxinus excelsior. Their structures were elucidated as (2S,4S,3E)-methyl 3-ethylidene-4-(2-methoxy-2-oxoethyl)-2-[(6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]-3,4-dihydro-2H-pyran-5-carboxylate and (2S,4S,3E)-methyl 3-ethylidene-4-{2-[2-(4-hydroxyphenyl)ethyl]oxy-2-oxoethyl}-2-[(6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]-3,4-dihydro-2H-pyran-5-carboxylate, respectively, on the basis of NMR and MS data. Eight known compounds were identified as nuzhenide (3), GI3 (4), GI5 (5), ligstroside (6), oleoside 11-methyl ester (7), oleoside dimethyl ester (8), 1 '''-O-beta-D-glucosylformoside (9), and salidroside (10). Compounds 1-9 inhibited adipocyte differentiation in 3T3-L1 cells. Dilutions of the aqueous extract of F. excelsior (1: 10 000) as well as compounds 2, 3, 4, 5, and 8 activated the peroxisome proliferator-mediated receptor-alpha (PPAR alpha) reporter cell system in the range of 10(-4) M, compared to 10(-7)-10(-8) M for the synthetic PPARoL activiator. WY14,643. Both biological activity profiles support the hypothesis that inhibition of adipocyte differentiation and PPAR alpha-mediated mechanisms might be relevant pathways for the antidiabetic activity of F. excelsior extract.
C1 [Bai, Naisheng; He, Kan; Ibarra, Alvin; Bily, Antoine] Naturex Inc, S Hackensack, NJ 07606 USA.
   [Roller, Marc] Naturex SA, F-84911 Avignon 9, France.
   [Chen, Xiaozhuo] Ohio Univ, Dept Biomed Sci, Athens, OH 45701 USA.
   [Chen, Xiaozhuo] Ohio Univ, Edison Biotechnol Inst, Athens, OH 45701 USA.
   [Ruehl, Ralph] Univ Debrecen, Dept Biochem & Mol Biol, Med & Hlth Sci Ctr, Debrecen, Hungary.
   [Ruehl, Ralph] Hungarian Acad Sci, Apoptosis & Genom Res Ctr, Debrecen, Hungary.
   [Ruehl, Ralph] Paprika Bioanalyt BT, Debrecen, Hungary.
C3 University System of Ohio; Ohio University; University System of Ohio;
   Ohio University; University of Debrecen; Hungarian Academy of Sciences
RP He, K (corresponding author), Naturex Inc, 375 Huyler St, S Hackensack, NJ 07606 USA.
EM k.he@naturex.us
RI ; He, Kan/AAH-4945-2020
OI Ibarra, Alvin/0000-0003-3952-8489; He, Kan/0000-0002-0125-8383
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NR 28
TC 52
Z9 57
U1 2
U2 21
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0163-3864
EI 1520-6025
J9 J NAT PROD
JI J. Nat. Prod.
PD JAN
PY 2010
VL 73
IS 1
BP 2
EP 6
DI 10.1021/np9003118
PG 5
WC Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Plant Sciences; Pharmacology & Pharmacy
GA 544JY
UT WOS:000273654000002
PM 20000781
OA Green Submitted
DA 2026-05-27
ER

PT J
AU Mattioli, L
   Perfumi, M
AF Mattioli, Laura
   Perfumi, Marina
TI Effects of a Rhodiola rosea L. extract on acquisition and
   expression of morphine tolerance and dependence in mice
SO JOURNAL OF PSYCHOPHARMACOLOGY
LA English
DT Article
DE dependence; mice; morphine; Rhodiola rosea; tolerance; withdrawal
ID CORTICOTROPIN-RELEASING-FACTOR; CONDITIONED PLACE PREFERENCE; OPIATE
   WITHDRAWAL; UNDERGROUND PART; DRUG-ADDICTION; RATS; STRESS; RECEPTORS;
   SALIDROSIDE; ADAPTOGENS
AB This study investigated the effect of Rhodiola rosea L. extract on acquisition and expression of morphine tolerance and dependence in mice. Therefore animals were injected with repeated administration of morphine (10mg/kg, subcutaneous) twice daily for five or six days, in order to make them tolerant or dependent. Rhodiola rosea L. extract (0, 10, 15 and 20mg/kg) was administered by the intragastric route 60 min prior to each morphine injection (for acquisition) or prior the last injection of morphine or naloxone on test day (for tolerance or dependence expression, respectively). Morphine tolerance was evaluated by testing its analgesic effect in the tail flick test at the 1st and 5th days. Morphine dependence was evaluated by counting the number of withdrawal signs (jumping, rearing, forepaw tremor, teeth chatter) after naloxone injection (5mg/kg; intraperitoneal) on the test day (day 6). Results showed that Rhodiola rosea L. extract significantly reduced the expression of morphine tolerance, while it was ineffective in modulating its acquisition. Conversely, Rhodiola rosea L. extract significantly and dose-dependently attenuated both development and expression of morphine dependence after chronic or acute administration. These data suggest that Rhodiola rosea L. may have human therapeutic potential for treatment of opioid addiction.
C1 [Mattioli, Laura; Perfumi, Marina] Univ Camerino, Dept Expt Med & Publ Hlth, I-62032 Camerino, MC, Italy.
C3 University of Camerino
RP Perfumi, M (corresponding author), Univ Camerino, Dept Expt Med & Publ Hlth, Via Madonna delle Carceri, I-62032 Camerino, MC, Italy.
EM marina.perfumi@unicam.it
RI Perfumi, Marina Cecilia/D-6218-2012
OI Perfumi, Marina Cecilia/0000-0002-3686-0577
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NR 77
TC 13
Z9 13
U1 0
U2 17
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0269-8811
EI 1461-7285
J9 J PSYCHOPHARMACOL
JI J. Psychopharmacol.
PD MAR
PY 2011
VL 25
IS 3
BP 411
EP 420
DI 10.1177/0269881109359096
PG 10
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 726NI
UT WOS:000287729200012
PM 20142299
DA 2026-05-27
ER

PT J
AU Zhang, W
   Bi, SM
   Li, P
   Liu, JH
   Zhou, CM
   Wang, X
   Zhang, W
   Wang, H
   Tang, B
AF Zhang, Wen
   Bi, Simin
   Li, Ping
   Liu, Jihong
   Zhou, Chunmiao
   Wang, Xin
   Zhang, Wei
   Wang, Hui
   Tang, Bo
TI In Situ Observation of mtDNA Damage during Hepatic Ischemia-Reperfusion
SO ANALYTICAL CHEMISTRY
LA English
DT Article
ID OXIDATIVE DAMAGE; DNA; INJURY; CELLS; MITOCHONDRIA; INHIBITION;
   ACTIVATION; PROBE
AB Hepatic ischemia-reperfusion (IR) injury is a severe pathophysiological event during liver surgery or transplantation and could lead to liver failure or even death. The energy supply of mitochondria plays an essential role in preventing IR injury. Mitochondrial DNA (mtDNA) is involved in maintaining the balance of energy by participating in an oxidative phosphorylation process. However, the exact relationship between IR and mtDNA remains unclear by reason of the lack of an accurate real-time analysis method. Herein, we fabricated a mitochondria-targeting fluorescent probe (mtDNA-BP) to explore mtDNA stability and supervise the changes in mtDNA in IR liver. By virtue of pyridinium electropositivity and suitable size, mtDNA-BP could accumulate in mitochondria and insert into the mtDNA groove, which made mtDNA-BP fluoresce strongly. This is attributed to the reduction of the intramolecular rotation energy loss that is restricted by DNA. By in situ fluorescence imaging, we observed in real time that mtDNA damage was aggravated by deteriorating IR injury, so the ROS-mtDNA-mediated IR damage signal pathway was speculated. Furthermore, on the basis of mtDNA-BP real-time response capability for mtDNA, we established a drug-screening method for inhibiting IR injury and found superior therapeutic performance of two potential drugs: pioglitazone and salidroside. This work contributes to our understanding of mtDNA-related disease and provides a new drug analysis method.
C1 [Zhang, Wen; Bi, Simin; Li, Ping; Liu, Jihong; Zhou, Chunmiao; Wang, Xin; Zhang, Wei; Wang, Hui; Tang, Bo] Shandong Normal Univ, Collaborat Innovat Ctr Functionalized Probes Chem, Coll Chem Chem Engn & Mat Sci, Minist Educ,Inst Biomed Sci,Key Lab Mol & Nano Pr, Jinan 250014, Peoples R China.
C3 Shandong Normal University
RP Li, P; Tang, B (corresponding author), Shandong Normal Univ, Collaborat Innovat Ctr Functionalized Probes Chem, Coll Chem Chem Engn & Mat Sci, Minist Educ,Inst Biomed Sci,Key Lab Mol & Nano Pr, Jinan 250014, Peoples R China.
EM lip@sdnu.edu.cn; tangb@sdnu.edu.cn
RI ; Wang, Xin/HNQ-8257-2023; zhang, wen/KTI-4782-2024
OI Li, Ping/0000-0002-2356-0962; 
FU National Natural Science Foundation of China [21535004, 91753111,
   21675105, 22077075, 21927811]; Key Research and Development Program of
   Shandong Province [2018YFJH0502]; National Major Scientific and
   Technological Special Project for "Significant New Drugs Development"
   [2017ZX09301030004]
FX This work was supported by the National Natural Science Foundation of
   China (21535004, 91753111, 21675105, 22077075, and 21927811), the Key
   Research and Development Program of Shandong Province (2018YFJH0502),
   and National Major Scientific and Technological Special Project for
   "Significant New Drugs Development" (2017ZX09301030004).
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NR 46
TC 19
Z9 20
U1 3
U2 63
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0003-2700
EI 1520-6882
J9 ANAL CHEM
JI Anal. Chem.
PD APR 13
PY 2021
VL 93
IS 14
BP 5782
EP 5788
DI 10.1021/acs.analchem.0c05220
EA MAR 2021
PG 7
WC Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA RN9BU
UT WOS:000640647600016
PM 33783186
DA 2026-05-27
ER

PT J
AU Long, ZM
   Zhang, RW
   Zhao, X
   Meng, X
   Bi, KS
   Chen, XH
AF Long, Zhimin
   Zhang, Ruowen
   Zhao, Xu
   Meng, Xia
   Bi, Kaishun
   Chen, Xiaohui
TI Determination and pharmacokinetics of geniposidic acid in rat plasma
   after oral administration of Gardenia jasminoides fruit crude extract
   and Zhi-zi-chi decoction
SO BIOMEDICAL CHROMATOGRAPHY
LA English
DT Article
DE geniposidic acid; G.jasminoides fruit crude; Zhi-zi-chi decoction;
   pharmacokinetics; LC-MS
ID PERFORMANCE LIQUID-CHROMATOGRAPHY; IRIDOID GLUCOSIDES;
   CAPILLARY-ELECTROPHORESIS; GENIPIN
AB A simple and efficient liquid chromatographymass spectrometry method was developed and validated for the determination of geniposidic acid in rat plasma. After the addition of internal standard salidroside and acidification (0.1% formic acid, pH = 3.2), plasma samples were carried out by protein precipitation with acetonitrile and separated on a Kromasil C18 column (150 x 4.6 mm, 5 mu m) within a run time of 9.0 min. Analysis was performed in selected ion monitoring mode with a positive electrospray ionization interface. No endogenous interference was observed at retention times of the analytes because of the high specificity of selected ion monitoring mode. The linear range was 0.024.0 mu g/mL and the lower limit of quantification was 0.02 mu g/mL. The mean extraction recoveries of geniposidic acid and internal standard from rat plasma were all >88.0% and the matrix effects were within acceptance criteria (90110%). The validated method was successfully applied to the pharmacokinetic study of geniposidic acid in rat plasma after oral administration of G. jasminoides fruit crude extract and Zhi-zi-chi decoction, respectively. Copyright (c) 2013 John Wiley & Sons, Ltd.
C1 [Long, Zhimin; Zhao, Xu; Meng, Xia; Bi, Kaishun; Chen, Xiaohui] Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China.
   [Zhang, Ruowen] NYU, Sch Med, Nelson Inst Environm Med, Tuxedo Pk, NY 10987 USA.
C3 Shenyang Pharmaceutical University; New York University
RP Chen, XH (corresponding author), Shenyang Pharmaceut Univ, Sch Pharm, Wenhua Rd 103, Shenyang 110016, Peoples R China.
EM cxh_syphu@yahoo.com.cn
OI Zhang, Ruowen/0000-0003-1403-2356
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NR 17
TC 15
Z9 18
U1 0
U2 35
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0269-3879
EI 1099-0801
J9 BIOMED CHROMATOGR
JI Biomed. Chromatogr.
PD JUN
PY 2013
VL 27
IS 6
BP 812
EP 816
DI 10.1002/bmc.2871
PG 5
WC Biochemical Research Methods; Biochemistry & Molecular Biology;
   Chemistry, Analytical; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Pharmacology & Pharmacy
GA 126KH
UT WOS:000317613200020
PM 23420755
DA 2026-05-27
ER

PT J
AU Wang, WC
   Xia, YM
   Yang, B
   Su, XN
   Chen, JK
   Li, W
   Jiang, T
AF Wang, Wen-chen
   Xia, Yan-min
   Yang, Bo
   Su, Xiang-ni
   Chen, Jia-kuan
   Li, Wei
   Jiang, Tao
TI Protective Effects of Tyrosol against LPS-Induced Acute Lung Injury
   via Inhibiting NF-κB and AP-1 Activation and Activating the
   HO-1/Nrf2 Pathways
SO BIOLOGICAL & PHARMACEUTICAL BULLETIN
LA English
DT Article
DE acute lung injury (ALI); tyrosol(Tyr); nuclear factor (NF)-kappa B;
   activator protein (AP)-1; heme oxygenase (HO)-1; nuclear factor
   erythroid-2 related factor 2(Nrf2)
ID RESPIRATORY-DISTRESS-SYNDROME; PHENOLIC-COMPOUNDS; OXIDATIVE STRESS;
   TNF-ALPHA; MAPK; MICE; INFLAMMATION; ANTIOXIDANT; SALIDROSIDE;
   EXPRESSION
AB Tyrosol (Tyr) is a natural antioxidant that displays anti-oxidant and anti-inflammatory properties. The present study aimed to investigate the effect and mechanism of Tyr on lipopolysaccharide (LPS)-induced acute lung injury (ALI). In a mouse model, we found that pretreatment with Tyr significantly improved survival rate, attenuated lung permeability, ameliorated histopathological alterations, reduced expression of the inflammatory mediators and improved expression of the antioxidant enzyme. Further study revealed that Tyr markedly inhibited nuclear factor-kappa B (NF-kappa B) and activator protein-1 (AP-1) activation at both in vivo and in vitro levels. To investigate the underlying mechanism, we examined the impact of Tyr on the heme oxygenase (HO)-1/nuclear factor erythroid-2 related factor 2 (Nrf2) pathway in vivo and in vitro. The results showed that Tyr significantly improved the expression of HO-1 and the activation of Nrf2. This study offers novel evidence to support the efficacy of Tyr against ALI, which helps to clarify the underlying causes of the therapeutic effects behind Tyr.
C1 [Wang, Wen-chen; Xia, Yan-min; Chen, Jia-kuan; Jiang, Tao] Fourth Mil Med Univ, Tangdu Hosp, Dept Thorac Surg, 1 Xin Si Rd, Xian 710038, Peoples R China.
   [Yang, Bo] Tianjin First Ctr Hosp, Dept Thorac Surg, 24 Fu Kang Rd, Tianjin 300192, Peoples R China.
   [Su, Xiang-ni] Fourth Mil Med Univ, Dept Nursing, 169 Changlexi Rd, Xian 710032, Peoples R China.
   [Li, Wei] Fourth Mil Med Univ, Dept Histol & Embryol, 169 Changlexi Rd, Xian 710032, Peoples R China.
C3 Air Force Medical University; Air Force Medical University; Air Force
   Medical University
RP Jiang, T (corresponding author), Fourth Mil Med Univ, Tangdu Hosp, Dept Thorac Surg, 1 Xin Si Rd, Xian 710038, Peoples R China.; Li, W (corresponding author), Fourth Mil Med Univ, Dept Histol & Embryol, 169 Changlexi Rd, Xian 710032, Peoples R China.
EM liweipepeyato@163.com; jiangtaochest@163.com
FU Shaanxi science and technology projects [2016SF-202]
FX We thank Mr. Tao Li (Research Center of Traditional Chinese Medicine,
   Xijing Hospital, Fourth Military Medical University, Shaanxi Province of
   China) for assisting with the experiments and Shaanxi science and
   technology projects for providing support (2016SF-202).
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U1 0
U2 19
PU PHARMACEUTICAL SOC JAPAN
PI TOKYO
PA 2-12-15 SHIBUYA, SHIBUYA-KU, TOKYO, 150-0002, JAPAN
SN 0918-6158
J9 BIOL PHARM BULL
JI Biol. Pharm. Bull.
PD MAY
PY 2017
VL 40
IS 5
BP 583
EP 593
DI 10.1248/bpb.b16-00756
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA ET5JD
UT WOS:000400319100008
PM 28190857
OA gold
DA 2026-05-27
ER

PT J
AU Huang, ZH
   Nan, C
   Wang, HQ
   Su, Q
   Xue, WD
   Chen, YY
   Shan, X
   Duan, JN
   Chen, G
   Tao, WW
AF Huang, Zhiheng
   Nan, Chen
   Wang, Hanqing
   Su, Qiang
   Xue, Wenda
   Chen, Yanyan
   Shan, Xin
   Duan, Jinao
   Chen, Gang
   Tao, Weiwei
TI Crocetin ester improves myocardial ischemia via Rho/ROCK/NF-κB pathway
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE Crocetin ester; Myocardial ischemia; Rho; NF-kappa B
ID ACUTE LUNG INJURY; NUCLEOTIDE EXCHANGE FACTOR; TANSHINONE IIA SULFONATE;
   RHOA/RHO KINASE PATHWAY; RHO-KINASE; IN-VITRO; THERAPEUTIC TARGET;
   REPERFUSION INJURY; RATS; SALIDROSIDE
AB Crocetin ester (CE) is the active ingredient of Crocus sativus L. stigmas and Gardenia jasminoides Ellis fruit. The main purpose of the present study was to investigate the protective effect of CE on isoproterenol (ISO)-induced acute myocardial ischemia (AMI) through Rho/ROCK/NF-kappa B pathway and explore its underlying mechanism. Administration of CE (25 and 50 mg/kg) could significantly reduce the serum contents of pro-inflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6). In addition, pretreatment with CE attenuated the contents of creatine kinase (CK), malondialdehyde (MDA) and the activities of lactate dehydrogenase (LDH), superoxide dismutase (SOD) in serum. Treatment with CE also improved the histopathological alteration and decreased the ST elevation. Furthermore, CE could ameliorate the cardiac expressions of Cu, Zn-superoxide dismutase (SOD1), MDA5, Rho, ROCK, p-I kappa B and p-NF-kappa Bp65 in ISO-induced rats. It was assumed that CE might be a new therapeutic candidate for the treatment of AMI possibly through the inhibition of Rho/ROCK/NF-kappa B pathway. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Huang, Zhiheng; Su, Qiang; Xue, Wenda; Chen, Yanyan; Shan, Xin; Chen, Gang; Tao, Weiwei] Nanjing Univ Chinese Med, Sch Basic Biomed Sci, Ctr Translat Syst Biol & Neurosci, Nanjing 210023, Jiangsu, Peoples R China.
   [Duan, Jinao; Tao, Weiwei] Nanjing Univ Chinese Med, Jiangsu Collaborat Innovat Ctr Chinese Med Resour, Nanjing 210023, Jiangsu, Peoples R China.
   [Duan, Jinao; Tao, Weiwei] Nanjing Univ Chinese Med, Natl & Local Collaborat Engn Ctr Chinese Med Reso, Nanjing 210023, Jiangsu, Peoples R China.
   [Wang, Hanqing] Ningxia Med Univ, Coll Pharm, Ningxia 750004, Peoples R China.
   [Nan, Chen] Soochow Univ, Coll Med, Suzhou 215000, Peoples R China.
C3 Nanjing University of Chinese Medicine; Nanjing University of Chinese
   Medicine; Nanjing University of Chinese Medicine; Ningxia Medical
   University; Soochow University - China
RP Tao, WW (corresponding author), Nanjing Univ Chinese Med, Sch Basic Biomed Sci, Ctr Translat Syst Biol & Neurosci, Nanjing 210023, Jiangsu, Peoples R China.
EM taoweiweinanjing@126.com
RI ; Chen, Nan/OTH-6049-2025; Wang, Hanqing/JJD-8795-2023; Xue,
   Wenda/AAR-9273-2020
OI Chen, Gang/0000-0002-3507-1218; Wang, Hanqing/0000-0003-1010-6098; 
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NR 43
TC 33
Z9 36
U1 0
U2 22
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD SEP
PY 2016
VL 38
BP 186
EP 193
DI 10.1016/j.intimp.2016.05.025
PG 8
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA DT5RQ
UT WOS:000381540700023
PM 27285672
DA 2026-05-27
ER

PT J
AU Chen, T
   Jiang, WJ
   Zhang, HX
   You, XT
   Liu, ML
   Wang, LN
   Xiang, PJ
   Xu, LJ
   Zheng, DS
   Zhang, XJ
   Ji, H
   Hao, K
   Yan, TH
AF Chen, Tong
   Jiang, Wenjiao
   Zhang, Huixin
   You, Xintong
   Liu, Manling
   Wang, Linna
   Xiang, Pengjun
   Xu, Lijie
   Zheng, Dongseng
   Zhang, Xuejiao
   Ji, Hui
   Hao, Kun
   Yan, Tianhua
TI Protective effect of trillin against ethanol-induced acute gastric
   lesions in an animal model
SO RSC ADVANCES
LA English
DT Article
ID ACUTE LUNG INJURY; KINASE C-ZETA; NF-KAPPA-B; ULCER; PHOSPHORYLATION;
   INFLAMMATION; SALIDROSIDE; INVOLVEMENT; MECHANISM; CYTOKINES
AB The purpose of the present study was to evaluate gastroprotective effect of trillin on mucosal lesions induced by ethanol. Mice were orally administered with trillin (25 mg kg(-1), 50 mg kg(-1), 100 mg kg(-1)) or OME (20 mg kg(-1)). 1 hour later, the mice were intragastrically given ethanol (0.2 ml kg(-1)) and were sacrificed at 4 h after ethanol administration. Compared with the ethanol group, trillin treatment significantly showed increased levels of superoxide dismutase (SOD) in serum, decreased malonaldehyde (MDA) content in serum and decreased activity of myeloperoxidase (MPO) in stomach tissues, which suggested that trillin could prevent oxidative damage. Meanwhile, the serum levels of interleukin-6 (IL-6), interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) declined after pretreatment with trillin. In HE staining sections, ameliorative pathological changes of gastric lesions were markedly observed in the trillin group compared with those in the ethanol group. In the mechanistic study, the data showed that pretreatment with the trillin also effectively down-regulated protein expressions of p-NF-kappa Bp65, p-I kappa B alpha and COX-2 in stomachs compared with those in the model group. Taken together, it could be concluded that trillin represented a potential therapeutic option to reduce the risk of gastric ulceration.
C1 [Chen, Tong; Jiang, Wenjiao; Wang, Linna; Xiang, Pengjun; Xu, Lijie; Zheng, Dongseng; Zhang, Xuejiao; Ji, Hui; Hao, Kun; Yan, Tianhua] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Peoples R China.
   [Zhang, Huixin] Nanjing Med Univ, Dept Neurobiol, Nanjing 210029, Peoples R China.
   [You, Xintong] Nanjing Forestry Univ, Dept Polymer Mat & Engn, Nanjing 210037, Jiangsu, Peoples R China.
   [Liu, Manling] China Pharmaceut Univ, Sch Pharm, Nanjing 210009, Peoples R China.
   [Yan, Tianhua] China Pharmaceut Univ, Dept Physiol & Pharmacol, Nanjing 210009, Peoples R China.
C3 China Pharmaceutical University; Nanjing Medical University; Nanjing
   Forestry University; China Pharmaceutical University; China
   Pharmaceutical University
RP Ji, H; Hao, K; Yan, TH (corresponding author), China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Peoples R China.; Yan, TH (corresponding author), China Pharmaceut Univ, Dept Physiol & Pharmacol, Nanjing 210009, Peoples R China.
EM huijicpu@163.com; haokun@cpu.edu.cn; yantianhuabest@126.com
RI Wang, Linna/ADO-8935-2022; Su, Tianyuan/Y-7054-2019; Xu,
   Lijie/J-5190-2016; Liu, Manling/PWG-1484-2026
FU National Twelve Five Major Drug Discovery Project [2011ZX09102-0 02-01];
   Natural Science Foundation of China [81302839]
FX This work was supported by the National Twelve Five Major Drug Discovery
   Project (no. 2011ZX09102-0 02-01) and Natural Science Foundation of
   China (81302839).
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NR 33
TC 32
Z9 38
U1 0
U2 22
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
EI 2046-2069
J9 RSC ADV
JI RSC Adv.
PY 2016
VL 6
IS 24
BP 20081
EP 20088
DI 10.1039/c5ra21158a
PG 8
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA DF1TU
UT WOS:000371122900058
DA 2026-05-27
ER

PT J
AU Chiang, HM
   Chien, YC
   Wu, CH
   Kuo, YH
   Wu, WC
   Pan, YY
   Su, YH
   Wen, KC
AF Chiang, Hsiu-Mei
   Chien, Yin-Chih
   Wu, Chieh-Hsi
   Kuo, Yueh-Hsiung
   Wu, Wan-Chen
   Pan, Yu-Yun
   Su, Yu-Han
   Wen, Kuo-Ching
TI Hydroalcoholic extract of Rhodiola rosea L. (Crassulaceae) and
   its hydrolysate inhibit melanogenesis in B16F0 cells by regulating the
   CREB/MITF/tyrosinase pathway
SO FOOD AND CHEMICAL TOXICOLOGY
LA English
DT Article
DE Rhodiola rosea; Melanin; Tyrosinase; MC1R; CREB; GSK3 beta
ID MELANIN SYNTHESIS; HUMAN MELANOCYTES; TYROSINASE; KINASE;
   MICROPHTHALMIA; PIGMENTATION; PERFORMANCE; MECHANISM; SYNTHASE; OXIDASE
AB We investigated the effects of an aqueous alcohol extract of Rhodiola rosea (R. rosea) and its hydrolysate on melanin synthesis and the mechanisms mediating the activity. The ratio of tyrosol to salidroside was 2.3 in hydroalcoholic extract, and 51.0 in hydrolysate. We found that R. rosea extract and its hydrolysate inhibited melanin synthesis and tyrosinase activity in mouse melanoma cells (B16F0 cells). R. rosea extract also inhibited gene and protein expression of melanocortin 1 receptor (MC1R) and inhibited c-AMP response element binding protein (CREB) phosphorylation, suppressed the activation of ART and glycogen synthase kinase-3 beta (GSK3 beta), and inhibited the expression of microphthalmia-associated transcription factor (MITF) and tyrosinase-related protein 1 (TRP-1). R. rosea hydrolysate inhibited the phosphorylation of CREB, the activation of AKT and GSK3 beta, and the expression of MITF and tyrosinase. Our results suggest that R. rosea extract is a novel tyrosinase inhibitor and that it exerts its effects by regulating the CREB/MITF/tyrosinase pathway in B16F0. Further in vivo studies are needed to determine the effectiveness of R. rosea extract as a skin whitening agent. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Chiang, Hsiu-Mei; Chien, Yin-Chih; Wu, Wan-Chen; Pan, Yu-Yun; Su, Yu-Han; Wen, Kuo-Ching] China Med Univ, Dept Cosmeceut, Taichung 404, Taiwan.
   [Chien, Yin-Chih; Wu, Chieh-Hsi] China Med Univ, Grad Inst Pharm, Taichung, Taiwan.
   [Kuo, Yueh-Hsiung] China Med Univ, Dept Chinese Pharmaceut Sci & Chinese Med Resourc, Taichung 404, Taiwan.
   [Kuo, Yueh-Hsiung] Asia Univ, Dept Biotechnol, Taichung 413, Taiwan.
C3 China Medical University Taiwan; China Medical University Taiwan; China
   Medical University Taiwan; Asia University Taiwan
RP Chiang, HM (corresponding author), China Med Univ, Dept Cosmeceut, Taichung 404, Taiwan.
EM hmchiang@mail.cmu.edu.tw; kcwen0520@mail.cmu.edu.tw
RI Wu, Chieh-Hsi/AAJ-1173-2020; Chiang, Hsiu-Mei/L-8150-2013
OI Wu, Chieh-Hsi/0000-0002-2006-8243; 
FU China Medical University, Taichung [CMU97-270, CMU97-271]; National
   Science Council, Taipei, Taiwan [NSC 96-2320-B-039-010]
FX This study was partly sponsored by the China Medical University
   (CMU97-270; CMU97-271), Taichung, and National Science Council (NSC
   96-2320-B-039-010), Taipei, Taiwan. The authors are grateful to Dr.
   Brian CS Lee for his contribution to experimental technique and
   equipment support and to Ko-Da Pharmaceutical Co. Ltd for supplying some
   experimental materials.
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NR 47
TC 76
Z9 86
U1 0
U2 70
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-6915
EI 1873-6351
J9 FOOD CHEM TOXICOL
JI Food Chem. Toxicol.
PD MAR
PY 2014
VL 65
BP 129
EP 139
DI 10.1016/j.fct.2013.12.032
PG 11
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA AC4OL
UT WOS:000332500500017
PM 24380755
DA 2026-05-27
ER

PT J
AU Qian, CJL
   Wang, SZ
   Chen, HY
   Li, JK
AF Qian, Chengjialu
   Wang, Shizhao
   Chen, Hongyan
   Li, Jiankuan
TI Ultrasound-assisted matrix solid-phase extraction based on deep eutectic
   solvents and zinc oxide: Extraction and determination of six active
   ingredients in Ligustri Lucidi Fructus
SO JOURNAL OF SEPARATION SCIENCE
LA English
DT Article
DE deep eutectic solvent; high performance liquid chromatography; Ligustri
   Lucidi Fructus; ultrasonic matrix solid-phase dispersion; zinc oxide
ID OLEANOLIC ACID; URSOLIC ACID; DISPERSION
AB In this study, we propose a novel strategy utilizing deep eutectic solvents (DESs) as both the extraction solvent and dispersing liquid, with nanometer zinc oxide (ZnO) serving as the adsorbent. This method incorporates ultrasound-assisted matrix solid phase dispersion (UA-MSPD) for the extraction of six active components (salidroside, echinacoside, acteoside, specnuezhenide, nuezhenoside G13, and oleanolic acid) from Ligustri Lucidi Fructus samples. The extracts were then analyzed using high-performance liquid chromatography equipped with a diode array detector. The effects of various parameters such as dispersant dosage, DESs volume, grinding time, ultrasonication duration, and eluent volume on extraction recovery were investigated and optimized using a central composite design under response surface methodology. The optimized conditions yielded detection limits ranging from 0.003 to 0.01 mg/g and relative standard deviations of 8.7% or lower. Extraction recoveries varied between 93% and 98%. The method demonstrated excellent linearity for the analytes (R-2 >= 0.9997). The simple, green, and efficient DESs/ZnO-UA-MSPD technique proved to be rapid, accurate, and reliable for extracting and analyzing the six active ingredients in Ligustri Lucidi Fructus samples.
C1 [Qian, Chengjialu; Wang, Shizhao] Hebei Univ Technol, Sch Chem Engn & Technol, Tianjin, Peoples R China.
   [Chen, Hongyan] Hebei Prov Hosp Tradit Chinese Med, Inst Technol Chinese Med Preparat Ind, Shijiazhuang, Peoples R China.
   [Li, Jiankuan] Shanxi Med Univ, Sch Pharmaceut Sci, Taiyuan 030001, Peoples R China.
C3 Hebei University of Technology; Hebei University of Chinese Medicine;
   Shanxi Medical University
RP Li, JK (corresponding author), Shanxi Med Univ, Sch Pharmaceut Sci, Taiyuan 030001, Peoples R China.; Chen, HY (corresponding author), Hebei Prov Hosp Tradit Chinese Med, Shijiazhuang 050000, Peoples R China.
EM shizhaow@163.com; Lijiankuan2004@163.com
RI Jiankuan, Li/J-7237-2019
FU Scientific Research Plan Project of Hebei Administration of Traditional
   Chinese Medicine [2022047, 2023044]; Key Research & Development Program
   of Hebei [22373101D]
FX This research was supported by the Key Research & Development Program of
   Hebei (22373101D)and the Scientific Research Plan Project of Hebei
   Administration of Traditional Chinese Medicine (2022047 and 2023044).
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NR 34
TC 4
Z9 5
U1 2
U2 24
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 1615-9306
EI 1615-9314
J9 J SEP SCI
JI J. Sep. Sci.
PD AUG 2
PY 2024
VL 47
IS 15
AR 2400275
DI 10.1002/jssc.202400275
PG 11
WC Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA A5G9I
UT WOS:001282824100001
PM 39091185
DA 2026-05-27
ER

PT J
AU Holla, V
   Antosova, M
   Karkeszova, K
   Mastihuba, V
   Polakovic, M
AF Holla, Veronika
   Antosova, Monika
   Karkeszova, Klaudia
   Mastihuba, Vladimir
   Polakovic, Milan
TI Screening of Commercial Enzymes for Transfructosylation of Tyrosol:
   Effect of Process Conditions and Reaction Network
SO BIOTECHNOLOGY JOURNAL
LA English
DT Article
DE beta-biocatalyst; fructofuranosidase; transfructosylation; tyrosol
   glycoside; tyrosol beta-d-fructofuranoside
ID ENZYMATIC-SYNTHESIS; BETA-GALACTOSIDASE; FRUCTOSYLTRANSFERASE;
   SALIDROSIDE; ANTIOXIDANT; PURIFICATION
AB Enzymatic fructosylation of organic acceptors other than saccharides brings new possibilities to synthesize molecules that do not exist in nature. The introduction of fructosyl moiety may lead to glycosides possessing enhanced physicochemical and bioactive properties which could be useful in the pharmaceutical and cosmetic industry. In this work, the regioselective synthesis of tyrosol beta-d-fructofuranoside (TF) catalyzed by beta-fructofuranosidase is investigated. In the first step, 32 commercial enzyme preparations are screened for fructoside-hydrolyzing activity. The most active preparations are subsequently examined for fructofuranosyl transfer from sucrose to tyrosol. The best candidate, Novozym 188, is chosen to study the effect of reaction conditions on the product formation in a batch reactor. The effects of substrate concentration, temperature, pH, time, and enzyme dosage on the concentration of TF produced are studied using the design of experiments methodology. The maximal product concentration of 3.8 g L-1 is achieved for the sucrose concentration of 1.5 m, tyrosol concentration of 29 g L-1, temperature of 41 degrees C, and pH 5.1. Besides the main transfructosylation reaction between sucrose and tyrosol, several side reactions take place. A reaction network includes also the formation of fructooligosaccharides and the hydrolysis of sucrose and all reaction products.
C1 [Holla, Veronika; Antosova, Monika; Karkeszova, Klaudia; Polakovic, Milan] Slovak Univ Technol Bratislava, Fac Chem & Food Technol, Inst Chem & Environm Engn, Dept Chem & Biochem Engn, Radlinskeho 9, Bratislava 81237, Slovakia.
   [Mastihuba, Vladimir] Slovak Acad Sci, Inst Chem, Dubravska Cesta 9, Bratislava 84538, Slovakia.
C3 Slovak University of Technology Bratislava; Slovak Academy of Sciences;
   Institute of Chemistry, SAS
RP Polakovic, M (corresponding author), Slovak Univ Technol Bratislava, Fac Chem & Food Technol, Inst Chem & Environm Engn, Dept Chem & Biochem Engn, Radlinskeho 9, Bratislava 81237, Slovakia.
EM milan.polakovic@stuba.sk
RI Antosova, Monika/HFZ-9237-2022; Polakovic, Milan/A-1080-2015; Mastihuba,
   Vladimír/S-7938-2017
OI Antosova, Monika/0000-0003-3671-9108; Polakovic,
   Milan/0000-0003-0238-8996; Mastihuba, Vladimír/0000-0003-2587-2553
FU Agentúra Ministerstva školstva, vedy, výskumu a športu SR [ITMS
   26240220084] Funding Source: Medline; Agentúra na Podporu Výskumu a
   Vývoja [APVV-16-0111] Funding Source: Medline; Vedecká Grantová Agentúra
   MŠVVaŠ SR a SAV [VEGA 1/0573/17] Funding Source: Medline
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NR 31
TC 7
Z9 7
U1 0
U2 17
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 1860-6768
EI 1860-7314
J9 BIOTECHNOL J
JI Biotechnol. J.
PD AUG
PY 2019
VL 14
IS 8
SI SI
AR 1800571
DI 10.1002/biot.201800571
PG 9
WC Biochemical Research Methods; Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
GA IM3ST
UT WOS:000477915800010
PM 30927487
DA 2026-05-27
ER

PT J
AU Yang, WH
   Peng, T
   Li, TG
   Cen, JR
   Wang, J
AF Yang, Wenhan
   Peng, Ting
   Li, Tingge
   Cen, Juren
   Wang, Jian
TI Tyramine and tyrosine decarboxylase gene contributes to the formation of
   cyanic blotches in the petals of pansy (Viola x
   wittrockiana)
SO PLANT PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Tyrosine decarboxylase gene; Co-pigment; Anthocyanin; Flower color
   patterning; Tyramine
ID FLOWER COLOR; ANTHOCYANIN; COPIGMENTATION; BIOSYNTHESIS; ACCUMULATION;
   EXPRESSION; STABILITY; PATHWAY; ACID
AB Tyrosine decarboxylase (TYDC) can catalyze tyrosine into tyramine. Several studies demonstrated its roles in the acidity, salidroside and defense response. Here we found that TYDC from Viola x wittrockiana Gam (VwTYDC) may contribute to the formation of cyaninc blotches in the petal. VwTYDC gene were cloned from Viola x wittrockiana and the cDNA full-length sequences were 1634 bp encoding 494 amino acids. Gene expression of VwTYDC in different tissues and developmental stages showed that they were significantly higher expressed in flowers than stems, leaves and roots. In addition, VwTYDC expression were higher in cyanic blotches than those observed in acyanic blotches of petal. Metabolites analysis showed the contents of tyramine in cyanic blotches were also higher than that in acyanic areas. Furthermore, in vitro assay revealed the absorption peak of anthocyanins had a red shift and an increase when fed tyramine. We speculated that tyramine might contribute to flower color expression of pansy as co-pigment. Our study demonstrated for the first time that the contents of tyramine led to flower blotches formation in cyanic blotches of the petals in plant flowers, and this may due to the higher expression of VwTYDC gene.
C1 [Yang, Wenhan; Li, Tingge; Cen, Juren; Wang, Jian] Hainan Univ, Trop Forestry Res Ctr, Inst Trop Agr & Forestry, Haikou 570223, Hainan, Peoples R China.
   [Peng, Ting] Guizhou Univ, Coll Agr, Guiyang 550025, Guizhou, Peoples R China.
C3 Hainan University; Guizhou University
RP Wang, J (corresponding author), Hainan Univ, Trop Forestry Res Ctr, Inst Trop Agr & Forestry, Haikou 570223, Hainan, Peoples R China.
EM wjhnau@163.com
FU National Natural Science Foundation of China [31260488, 31760590]
FX This research was supported by the National Natural Science Foundation
   of China (Grant No. 31260488, 31760590).
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NR 30
TC 11
Z9 14
U1 0
U2 43
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0981-9428
J9 PLANT PHYSIOL BIOCH
JI Plant Physiol. Biochem.
PD JUN
PY 2018
VL 127
BP 269
EP 275
DI 10.1016/j.plaphy.2018.03.024
PG 7
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences
GA GI8DG
UT WOS:000434751400028
PM 29631211
DA 2026-05-27
ER

PT J
AU Fuji, Y
   Ohtsuki, T
   Matsufuji, H
AF Fuji, Yushiro
   Ohtsuki, Takashi
   Matsufuji, Hiroshi
TI Accumulation and Subcellular Localization of Acteoside in Sesame Plants
   (Sesamum indicum L.)
SO ACS OMEGA
LA English
DT Article
ID PHENYLPROPANOID GLYCOSIDE; PHENYLETHANOID GLYCOSIDES; ANTIOXIDANT
   ACTIVITY; IRIDOID GLUCOSIDES; TEMPERATURE; POLYPHENOLS; TRICHOMES;
   CULTURES
AB The localization of acteoside and its precursors in different organs of sesame plant (Sesamum indicum L.), including roots, stems (epidermis, cortex, and stele), leaves (blades and petioles), flower petals, and seeds (immature and mature) was investigated. The highest acteoside content was found in leaf blades (12.3% dry weight), followed by in petioles (3.1%) and petals (2.7%) and at a trace levels or not detected in other organs. In contrast, the known precursors of acteoside, cinnamate, p-coumarate, caffeate, tyramine, tyrosol, salidroside, L-3,4-dihydroxyphenylalanine,dopamine, and hydroxytyrosol were not detected in any organs, even by multiple-reaction monitoring analysis by liquid chromatography-electrospray ionization tandem mass spectrometry, despite acteoside being present at high levels in the leaves. The leaves stained with diphenylborinic acid 2-aminoethyl ester (DPBA), producing the acteoside-DPBA complex that was detected by fluorescence at an excitation wavelength of 365 nm, showed accumulation of acteoside at the veins and glandular trichomes. For the first time, the leaf blade organ was shown to contain a large amount of acteoside in the sesame plant, with acteoside synthesis in the leaf petioles and/or blades and accumulation in the glandular trichomes with transport through the veins. However, tyrosine and phenylalanine contents were very low with no downstream metabolites or known acteoside precursors detected in any organs.
C1 [Fuji, Yushiro; Ohtsuki, Takashi; Matsufuji, Hiroshi] Nihon Univ, Dept Food Biosci & Biotechnol, Coll Bioresource Sci, 1866 Kameino, Fujisawa, Kanagawa 2520880, Japan.
C3 Nihon University
RP Matsufuji, H (corresponding author), Nihon Univ, Dept Food Biosci & Biotechnol, Coll Bioresource Sci, 1866 Kameino, Fujisawa, Kanagawa 2520880, Japan.
EM hmatsufu@brs.nihon-u.ac.jp
OI Fuji, Yushiro/0009-0004-4465-7175
FU Nihon University President Grant Initiative; JSPS KAKENHI [JP15K12247]
FX We are grateful to Prof. Satoshi Kubota of the Department of
   Agricultural Bioscience, College of Bioresource Sciences, Nihon
   University for valuable discussions and technical support in the
   cultivation of S. indicum L. We are also thankful to the General
   Research Institute of Nihon University for LC-ESI-MS/MS measurements.
   This study was financially supported by the Nihon University President
   Grant Initiative and JSPS KAKENHI Grant Number JP15K12247.
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TC 19
Z9 20
U1 1
U2 16
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 2470-1343
J9 ACS OMEGA
JI ACS Omega
PD DEC
PY 2018
VL 3
IS 12
BP 17287
EP 17294
DI 10.1021/acsomega.8b02798
PG 8
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA HF5AJ
UT WOS:000454244600099
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU He, FW
   Chen, L
   Liu, Q
   Wang, X
   Li, J
   Yu, JQ
AF He, Fengwei
   Chen, Li
   Liu, Qian
   Wang, Xiao
   Li, Jia
   Yu, Jinqian
TI Preparative Separation of Phenylethanoid and Secoiridoid Glycosides from
   Ligustri Lucidi Fructus by High-Speed Counter-Current Chromatography
   Coupled with Ultrahigh Pressure Extraction
SO MOLECULES
LA English
DT Article
DE high-speed counter-current chromatography; phenylethanoid glycoside;
   secoiridoid glycoside Ligustri Lucidi Fructus; ultrahigh pressure
   extraction
ID FRUITS; PURIFICATION; GLUCOSIDES
AB Three phenylethanoid glycosides, echinacoside (1), salidroside (3), and acteoside (6), and three secoiridoid glycosides, isonuezhenide (2), nuezhenoside G13 (4), and specnuezhenide (5), have been extracted and separated by a combined method of ultrahigh pressure extraction (UPE) and high-speed counter-current chromatography (HSCCC) from Ligustri Lucidi Fructus. For the UPE, the optimal extraction was developed with conditions including solvent of 90% ethanol, sample to solvent ratio of 1:20 g/mL, pressure of 200 MPa, and time of 2 min, which rendered the yields of compounds 4 and 5 were 15.0 and 78.0 mg/g, respectively. For the HSCCC separation, the strategy of changing flow rates between 1.0 and 2.0 mL/min allowed the acquisition for 2.7 mg of compound 1, 4.5 mg of compound 2, 6.8 mg of compound 3, 5.9 mg of compound 4, 11.2 mg of compound 5, and 2.2 mg of compound 6 in one separation run under the solvent system of ethyl acetate:n-butanol:water (2:1:3, v/v) from 200 mg of the UPE extract. The structures of these phenylethanoid and secoiridoid glycosides were elucidated by extensive spectroscopic methods.
C1 [He, Fengwei; Chen, Li] Liaoning Inst Sci & Technol, Benxi 117004, Peoples R China.
   [Liu, Qian; Wang, Xiao; Yu, Jinqian] Qilu Univ Technol, Shandong Acad Sci, Shandong Anal & Test Ctr, Shandong Key Lab TCM Qual Control Technol, Jinan 250014, Shandong, Peoples R China.
   [Li, Jia] Shandong Univ Tradit Chinese Med, Coll Pharm, Jinan 250355, Shandong, Peoples R China.
C3 Liaoning Institute of Science & Technology; Qilu University of
   Technology; Shandong University of Traditional Chinese Medicine
RP Yu, JQ (corresponding author), Qilu Univ Technol, Shandong Acad Sci, Shandong Anal & Test Ctr, Shandong Key Lab TCM Qual Control Technol, Jinan 250014, Shandong, Peoples R China.; Li, J (corresponding author), Shandong Univ Tradit Chinese Med, Coll Pharm, Jinan 250355, Shandong, Peoples R China.
EM hfwdd@163.com; chenlilycharming@126.com; 18765878227@126.com;
   wangx@sdas.org; ljytl7172@163.com; yujinqian87528@126.com
RI Wang, Xiao/R-5243-2019
FU Shandong Province Taishan Scholar Program; Priority Research Program of
   the Shandong Academy of Sciences
FX This research was funded by The Shandong Province Taishan Scholar
   Program (Lanping Guo) and The Priority Research Program of the Shandong
   Academy of Sciences (LanpingGuo).
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Z9 27
U1 0
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD DEC
PY 2018
VL 23
IS 12
AR 3353
DI 10.3390/molecules23123353
PG 11
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA HF8WN
UT WOS:000454523000303
PM 30567348
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhu, CX
   Guan, FC
   Wang, C
   Jin, LH
AF Zhu, Caixia
   Guan, Fachun
   Wang, Chao
   Jin, Li Hua
TI The Protective Effects of Rhodiola crenulata Extracts on
   Drosophila melanogaster Gut Immunity Induced by Bacteria and SDS
   Toxicity
SO PHYTOTHERAPY RESEARCH
LA English
DT Article
DE Rhodiola crenulata; gut immunity; Drosophila melanogaster; ROS; survival
   rate
ID HOST-DEFENSE; SALIDROSIDE; INFECTION; TYROSOL
AB The aim of this study was to observe the effect of the Rhodiola crenulata extracts on gut immunity of Drosophila melanogaster. Wild-type flies fed standard cornmeal-yeast medium were used as controls. Experimental groups were supplemented with 2.5% R.crenulata aqueous extracts in standard medium. Survival rate was determined by feeding pathogenic microorganisms and toxic compounds. The levels of reactive oxygen species and dead cells were detected by dihydroethidium and 7-amino-actinomycin D staining, respectively. The expression of antimicrobial peptides was evaluated by quantitative polymerase chain reaction, and morphological change of the intestine was imaged by an Axioskop 2 plus microscope. The results demonstrate that R.crenulata increased the survival rates of adult flies and expression of antimicrobial peptide genes after pathogen or toxic compound ingestion. Moreover, decreased levels of reactive oxygen species and epithelial cell death were associated with results in improved intestinal morphology. The pharmacological action of R.crenulata from Tibet was greater than that from Sichuan. These results indicate that the R.crenulata extracts from Tibet had better pharmacological effect on D.melanogaster gut immunity after ingestion of pathogens and toxic compounds. These results may provide the pharmacological basis for prevention of inflammatory diseases of the intestine. Copyright (c) 2014 John Wiley & Sons, Ltd.
C1 [Zhu, Caixia; Jin, Li Hua] Northeast Forestry Univ, State Key Lab Forest Genet & Tree Breeding, Harbin 150040, Peoples R China.
   [Zhu, Caixia; Jin, Li Hua] Northeast Forestry Univ, Coll Life Sci, Harbin 150040, Peoples R China.
   [Guan, Fachun; Wang, Chao] Tibet Univ, Linzhi 860000, Peoples R China.
C3 Northeast Forestry University - China; Northeast Forestry University -
   China; Xizang University
RP Jin, LH (corresponding author), Northeast Forestry Univ, Coll Life Sci, Harbin 150040, Peoples R China.
EM lhjin2000@hotmail.com
FU National Natural Science Foundation of China [31270923]; Fundamental
   Research Funds for the Central Universities [DL13EA08-01]; National
   Science and Technology Support Program [2011BAI13B06]
FX This work was supported by the National Natural Science Foundation of
   China (31270923), the Fundamental Research Funds for the Central
   Universities (DL13EA08-01), and the National Science and Technology
   Support Program (2011BAI13B06).
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PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
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WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA AW1QF
UT WOS:000346063700017
PM 25146450
DA 2026-05-27
ER

PT J
AU Malarz, J
   Yudina, YV
   Stojakowska, A
AF Malarz, Janusz
   Yudina, Yulia V.
   Stojakowska, Anna
TI Hairy Root Cultures as a Source of Phenolic Antioxidants: Simple
   Phenolics, Phenolic Acids, Phenylethanoids, and Hydroxycinnamates
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE Agrobacterium rhizogenes; caffeoylquinic acid; chlorogenic acid;
   chicoric acid; phenolic acid; salvianolic acid; Rhizobium rhizogenes;
   rosmarinic acid; salidroside; verbascoside
ID RHIZOGENES-MEDIATED TRANSFORMATION; SECONDARY METABOLITE PRODUCTION;
   P-HYDROXYBENZOIC ACID; ACYL-QUINIC ACIDS; IN-VITRO CULTURES; ROSMARINIC
   ACID; CHLOROGENIC ACID; AGROBACTERIUM-RHIZOGENES; METHYL JASMONATE;
   CHICORIC ACID
AB Plant-derived antioxidants are intrinsic components of human diet and factors implicated in tolerance mechanisms against environmental stresses in both plants and humans. They are being used as food preservatives and additives or ingredients of cosmetics. For nearly forty years, Rhizobium rhizogenes-transformed roots (hairy roots) have been studied in respect to their usability as producers of plant specialized metabolites of different, primarily medical applications. Moreover, the hairy root cultures have proven their value as a tool in crop plant improvement and in plant secondary metabolism investigations. Though cultivated plants remain a major source of plant polyphenolics of economic importance, the decline in biodiversity caused by climate changes and overexploitation of natural resources may increase the interest in hairy roots as a productive and renewable source of biologically active compounds. The present review examines hairy roots as efficient producers of simple phenolics, phenylethanoids, and hydroxycinnamates of plant origin and summarizes efforts to maximize the product yield. Attempts to use Rhizobium rhizogenes-mediated genetic transformation for inducing enhanced production of the plant phenolics/polyphenolics in crop plants are also mentioned.
C1 [Malarz, Janusz; Stojakowska, Anna] Polish Acad Sci, Maj Inst Pharmacol, Smetna St 12, PL-31343 Krakow, Poland.
   [Yudina, Yulia V.] Natl Tech Univ, Educ & Sci Med Inst, Kharkiv Polytech Inst, Kyrpychova St 2, UA-61002 Kharkiv, Ukraine.
C3 Polish Academy of Sciences; Maj Institute of Pharmacology of the Polish
   Academy of Sciences; Ministry of Education & Science of Ukraine;
   National Technical University Kharkiv Polytechnic Institute
RP Stojakowska, A (corresponding author), Polish Acad Sci, Maj Inst Pharmacol, Smetna St 12, PL-31343 Krakow, Poland.
EM stoja@if-pan.krakow.pl
RI Stojakowska, Anna/AAQ-8747-2020; Yudina, Yulia/GQB-0697-2022
OI Stojakowska, Anna/0000-0001-9242-2072; Malarz,
   Janusz/0000-0001-5668-5940; Yudina, Yulia/0000-0002-5322-5786
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NR 193
TC 28
Z9 30
U1 4
U2 49
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR
PY 2023
VL 24
IS 8
AR 6920
DI 10.3390/ijms24086920
PG 29
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA E8EO0
UT WOS:000977811900001
PM 37108084
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Li, FY
   Liang, DJ
   Yang, ZT
   Wang, TC
   Wang, W
   Song, XJ
   Guo, MY
   Zhou, ES
   Li, DP
   Cao, YG
   Zhang, NS
AF Li Fengyang
   Liang Dejie
   Yang Zhengtao
   Wang Tiancheng
   Wang Wei
   Song Xiaojing
   Guo Mengyao
   Zhou Ershun
   Li Depeng
   Cao Yongguo
   Zhang Naisheng
TI Astragalin suppresses inflammatory responses via down-regulation of
   NF-κB signaling pathway in lipopolysaccharide-induced mastitis in a
   murine model
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE Astragalin; Lipopolysaccharide (LPS); Mastitis; Cytokine; Nuclear
   factor-kappaB (NF-kappa B)
ID ACTIVATION; ENDOTOXIN; CELLS; SALIDROSIDE; EXPRESSION; CYTOKINES; INNATE
AB Mastitis is a prevalent and economic disease around the world and defined as infection and inflammation of the mammary gland. Astragalin, a bioactive component isolated from persimmon or Rosa agrestis, has been reported to have anti-inflammatory properties. To investigate the potential therapeutic effect of astragalin in mastitis, a murine model of mastitis was induced by administration of LPS in mammary gland. Astragalin was applied 1 h before and 12 h after LPS treatment. The results showed that astragalin attenuated the infiltration of inflammatory cells, the activity of myeloperoxidase (MPO) and the expression of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1 beta (IL-1 beta) in a dose-dependent manner. Additionally, Western blotting results showed that astragalin efficiently blunt decreased nuclear factor-kappaB (NF-kappa B) activation by inhibiting the degradation and phosphorylation of I kappa B alpha and the nuclear translocation of p65. These results suggested that astragalin exerts anti-inflammatory properties in LPS-mediated mastitis, possibly through inhibiting inhibition of the NF-kappa B signaling pathway, which mediates the expression of pro-inflammatory cytokines. Astragalin may be a potential therapeutic agent against mastitis. (C) 2013 Elsevier B.V. All rights reserved.
C1 [Li Fengyang; Liang Dejie; Yang Zhengtao; Wang Tiancheng; Wang Wei; Song Xiaojing; Guo Mengyao; Zhou Ershun; Li Depeng; Cao Yongguo; Zhang Naisheng] Jilin Univ, Coll Vet Med, Dept Clin Vet Med, Changchun 130062, Jilin Province, Peoples R China.
C3 Jilin University
RP Cao, YG (corresponding author), Jilin Univ, Coll Vet Med, Dept Clin Vet Med, Changchun 130062, Jilin Province, Peoples R China.
EM ygcao82@jlu.edu.cn; zhangns@jlu.edu.cn
RI Guo, meng-yao/JOZ-4503-2023
OI Guo, meng-yao/0000-0002-7596-3632
FU National Natural Science Foundation of China [31272622, 3120195];
   Research Fund for the Doctoral Program of Higher Education of China
   [20110061130 010, 20120061120098]
FX This work was supported by a grant from the National Natural Science
   Foundation of China (No. 31272622, 3120195) and the Research Fund for
   the Doctoral Program of Higher Education of China (No. 20110061130 010,
   20120061120098).
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Z9 61
U1 1
U2 33
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD OCT
PY 2013
VL 17
IS 2
BP 478
EP 482
DI 10.1016/j.intimp.2013.07.010
PG 5
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA 227OC
UT WOS:000325122200044
PM 23928506
DA 2026-05-27
ER

PT J
AU Mao, GX
   Zheng, LD
   Cao, YB
   Chen, ZM
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AF Mao, Gen-Xiang
   Zheng, Ling-Di
   Cao, Yong-Bao
   Chen, Zhuo-Mei
   Lv, Yuan-Dong
   Wang, Ya-Zhen
   Hu, Xi-Lian
   Wang, Guo-Fu
   Yan, Jing
TI Antiaging Effect of Pine Pollen in Human Diploid Fibroblasts and in a
   Mouse Model Induced by D-Galactose
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID ADVANCED GLYCATION; ADVANCED GLYCOSYLATION; GROWTH-FACTOR; CELLS;
   ACCUMULATION; SALIDROSIDE; SENESCENCE; INHIBITORS; EXTRACT; MICE
AB The present paper was designed to investigate the effect of pine pollen against aging in human diploid fibroblast 2BS cells and in an accelerated aging model, which was established by subcutaneous injections with D-galactose daily for 8 weeks in C57BL/6J mice. Pine pollen (1 mg/mL and 2 mg/mL) is proved to delay the replicative senescence of 2BS cells as evidenced by enhanced cell proliferation, decreased SA-beta-Gal activity, and reversed expression of senescence-associated molecular markers, such as p53, p21(Waf1), p16(INK4a), PTEN, and p27(Kip1) in late PD cells. Besides, pine pollen reversed D-galactose-induced aging effects in neural activity and inflammatory cytokine levels, as indicated by improved memory latency time and reduced error rate in step-down test and decreased concentrations of IL-6 and TNF-alpha in model mice. Similar to the role of AGEs (advanced glycation endproducts) formation inhibitor aminoguanidine (AG), pine pollen inhibited D-galactose-induced increment of AGEs levels thus reversed the aging phenotypes in model mice. Furthermore, the declined antioxidant activity was obviously reversed upon pine pollen treatment, which may account for its inhibitory effect on nonenzymatic glycation (NEG) in vivo. Our finding presents pine pollen as an attractive agent with potential to retard aging and attenuate age-related diseases in humans.
C1 [Mao, Gen-Xiang; Zheng, Ling-Di; Cao, Yong-Bao; Lv, Yuan-Dong; Wang, Ya-Zhen; Hu, Xi-Lian; Wang, Guo-Fu; Yan, Jing] Zhejiang Hosp, Zhejiang Prov Key Lab Geriatr, Hangzhou 310013, Zhejiang, Peoples R China.
   [Chen, Zhuo-Mei] Zhejiang Forestry Acad, Hangzhou 310023, Zhejiang, Peoples R China.
RP Wang, GF (corresponding author), Zhejiang Hosp, Zhejiang Prov Key Lab Geriatr, 12 Lingyin Rd, Hangzhou 310013, Zhejiang, Peoples R China.
EM zpklg@yahoo.com.cn; zjicu@vip.163.com
FU Ministry of Health of China [WKJ2011-2-014]; Health Bureau of Zhejiang
   Province [11-CX01]; Science and Technology Department of Zhejiang
   Province [2008C33046]; Zhejiang Provincial Key Disciplinary Fields of
   Geriatrics Program
FX This paper was supported by a fund from Ministry of Health of China
   (WKJ2011-2-014), a fund from Health Bureau of Zhejiang Province
   (11-CX01), the Science and Technology Department of Zhejiang Province
   Program (2008C33046), and Zhejiang Provincial Key Disciplinary Fields of
   Geriatrics Program. The authors would like to thank the Zhejiang Yalin
   Biotechnology Co. Ltd. (Hangzhou, China) for providing the pine pollen.
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NR 34
TC 57
Z9 64
U1 0
U2 56
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2012
VL 2012
AR 750963
DI 10.1155/2012/750963
PG 10
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 938HE
UT WOS:000303723800001
PM 22577492
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Wang, J
   Zhang, ZY
   Yu, MX
   Xin, LY
AF Wang, Jing
   Zhang, Zhiyu
   Yu, Mingxia
   Xin, Linyan
TI Cold stimulated bronchial epithelial cells derived exosomes HMGB1
   aggravates bronchial epithelial cells injury
SO MOLECULAR IMMUNOLOGY
LA English
DT Article
DE Cold stimulates; ALI; Sepsis; Exosomes; HMGB1; Oxidative stress
ID ACUTE LUNG INJURY; SEPTIC SHOCK; SEPSIS; DEFINITIONS; SALIDROSIDE
AB The aim of this study was to reveal the mechanism of cold stimulation (CS)-bronchial epithelial cells (BECs) derived exosomes (CS-BECs-exo) aggravated sepsis induced acute lung injury (SALI). CS-BECs-exo were separated by differential centrifugation and were characterized. Proteomics, immunoprecipitation, and RAGE knockout (RAGE) mice were used to investigate the mechanism of CS-BECs-exo aggravated SALI. The results of transmission electron microscope (TEM) showed that CS-BECs-exo showed a double-layer membrane structure like a saucer. Nanoparticle tracking analysis (NTA) particle size analysis showed that the average particle size of CS-BECs-exo was 123.6 nm. The results of proteomics showed that the expression level HMGB1 was significantly increased in CS-BECs-exo compared with BECs-exo. CS-BECs-exo significantly increased oxidative stress and inflammatory reaction of SALI. In addition, CS-BECs-exo significantly increased RAGE and decreased the levels of Nrf-2 and OH-1. RAGE knockout (RAGE KO) and silence of RAGE (RAGE siRNA) significantly canceled the effects of CS-BECs-exo on SALI. HMGB1 knockout (HMGB1) and silence of HMGB1 also significantly (HMGB1 siRNA) canceled the effects of CS-BECs-exo on SALI. In conclusion, CS-BECs-exo aggravated ALI in sepsis via HMGB1/ RAGE/Nrf-2/OH-1 signal pathway.
C1 [Wang, Jing; Zhang, Zhiyu; Yu, Mingxia] Suzhou Univ, Inst Pharmaceut Pharmacol, Res Ctr, Sch Biol & Food Engn, Suzhou, Anhui, Peoples R China.
   [Xin, Linyan] Yancheng First Peoples Hosp, Pharm Dept, Yancheng, Peoples R China.
C3 Suzhou University
RP Wang, J (corresponding author), Suzhou Univ, Inst Pharmaceut Pharmacol, Res Ctr, Sch Biol & Food Engn, Suzhou, Anhui, Peoples R China.; Xin, LY (corresponding author), Yancheng First Peoples Hosp, Pharm Dept, Yancheng, Peoples R China.
EM 919706556@qq.com; 497358836@qq.com
FU Natural Science Foundation of Anhui Province [2208085QH261];
   Pharmaceutical Pharmacology Research Center [2021XJPT37ZC]; Suzhou
   University [2019jb06]
FX Youth fund of Natural Science Foundation of Anhui Province
   (2208085QH261) ; Pharmaceutical Pharmacology Research Center
   (2021XJPT37ZC) ; The start-up fund for doctoral research of Suzhou
   University (2019jb06) .
CR Abdulmandi W, 2017, REDOX BIOL, V13, P600, DOI 10.1016/j.redox.2017.08.001
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NR 19
TC 3
Z9 3
U1 2
U2 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0161-5890
EI 1872-9142
J9 MOL IMMUNOL
JI Mol. Immunol.
PD JAN
PY 2025
VL 177
BP 96
EP 103
DI 10.1016/j.molimm.2024.12.007
EA JAN 2025
PG 8
WC Biochemistry & Molecular Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Immunology
GA S6A8F
UT WOS:001399035900001
PM 39755020
DA 2026-05-27
ER

PT J
AU Marchev, AS
   Dinkova-Kostova, AT
   György, Z
   Mirmazloum, I
   Aneva, IY
   Georgiev, MI
AF Marchev, Andrey S.
   Dinkova-Kostova, Albena T.
   Gyorgy, Zsuzsanna
   Mirmazloum, Iman
   Aneva, Ina Y.
   Georgiev, Milen I.
TI Rhodiola rosea L.: from golden root to green cell factories
SO PHYTOCHEMISTRY REVIEWS
LA English
DT Article; Proceedings Paper
CT 2nd International Conference on Natural Products Utilization - From
   Plants to Pharmacy Shelf
CY OCT 14-17, 2015
CL Plovdiv, BULGARIA
SP Phytochem Soc Europe
DE Roseroot; Medicinal use; Clinical trials; In vitro systems; Secondary
   metabolites
ID IN-VITRO CULTURE; CALLUS AGGREGATE CULTURES; PEROXIDE-INDUCED INJURY;
   SALIDROSIDE PRODUCTION; CINNAMYL ALCOHOL; MONOTERPENE GLYCOSIDES;
   CHEMICAL-COMPOSITION; OXIDATIVE STRESS; NEUROPEPTIDE-Y; EXPRESSION
AB Rhodiola rosea L. is a worldwide popular plant with adaptogenic activities that have been and currently are exploited in the traditional medicine of many countries, as well as, examined in a number of clinical trials. More than 140 chemical structures have been identified which belong to several natural product classes, including phenylpropanoid glycosides, phenylethanoids, flavonoids and essential oils, and are mainly stored in the rhizomes and the roots of the plant. A number of mechanisms contribute to the adaptogenic activities of R. rosea preparations and its phytochemical constituents. Among them, the intrinsic inducible mammalian stress responses and their effector proteins, such as heat shock protein 70 (Hsp70), are the most prominent. Due to its popular medicinal use, which has led to depletion of its natural habitats, R. rosea is now considered as endangered in most parts of the world. Conservation, cultivation and micropropagation are all implemented as potential preservation strategies. A number of in vitro systems of R. rosea are being developed as sources of pharmaceutically valuable secondary metabolites. These are greatly facilitated by advances in elucidation of the biosynthetic pathways and the enzymes, which catalyse the production of these secondary metabolites in the plant. In addition, biotechnological approaches show promise towards achieving sustainable production of R. rosea secondary metabolites.
C1 [Marchev, Andrey S.; Georgiev, Milen I.] Bulgarian Acad Sci, Stephan Angeloff Inst Microbiol, Lab Appl Biotechnol, 139 Ruski Blvd, Plovdiv 4000, Bulgaria.
   [Marchev, Andrey S.; Georgiev, Milen I.] Ctr Plant Syst Biol & Biotechnol, Plovdiv 4000, Bulgaria.
   [Dinkova-Kostova, Albena T.] Univ Dundee, Sch Med, Div Canc Res, Jacqui Wood Canc Ctr, Dundee DD1 9SY, Scotland.
   [Dinkova-Kostova, Albena T.] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA.
   [Dinkova-Kostova, Albena T.] Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD 21205 USA.
   [Gyorgy, Zsuzsanna; Mirmazloum, Iman] Corvinus Univ Budapest, Dept Genet & Plant Breeding, Menesi Ut 44, H-1118 Budapest, Hungary.
   [Aneva, Ina Y.] Bulgarian Acad Sci, Inst Biodivers & Ecosyst Res, BU-1113 Sofia, Bulgaria.
C3 Bulgarian Academy of Sciences; Stephan Angeloff Institute of
   Microbiology, Bulgarian Academy of Sciences; University of Dundee; Johns
   Hopkins University; Johns Hopkins University; Corvinus University
   Budapest; Bulgarian Academy of Sciences
RP Marchev, AS (corresponding author), Bulgarian Acad Sci, Stephan Angeloff Inst Microbiol, Lab Appl Biotechnol, 139 Ruski Blvd, Plovdiv 4000, Bulgaria.; Marchev, AS (corresponding author), Ctr Plant Syst Biol & Biotechnol, Plovdiv 4000, Bulgaria.
EM andrey.marchev@yahoo.com
RI György, Zsuzsanna/L-7105-2016; Aneva, Ina/AAI-4487-2020; Georgiev, Milen
   I/P-6948-2015; Dinkova-Kostova, Albena/AEB-8168-2022; Marchev,
   Andrey/PFR-2450-2026; Mirmazloum, Iman/AAJ-5673-2020
OI György, Zsuzsanna/0000-0002-7803-5487; Aneva, Ina/0000-0002-6476-5438;
   Georgiev, Milen I/0000-0001-5248-6135; Dinkova-Kostova,
   Albena/0000-0003-0316-9859; Mirmazloum, Iman/0000-0002-1461-0382;
   Marchev, Aney/0000-0002-7660-683X
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NR 160
TC 48
Z9 56
U1 3
U2 54
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1568-7767
EI 1572-980X
J9 PHYTOCHEM REV
JI Phytochem. Rev.
PD AUG
PY 2016
VL 15
IS 4
SI SI
BP 515
EP 536
DI 10.1007/s11101-016-9453-5
PG 22
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Plant Sciences
GA DR0TD
UT WOS:000379618900002
OA Green Published
DA 2026-05-27
ER

PT J
AU Chen, YQ
   Sun, LJ
   Wang, Y
   Zhao, XP
AF Chen, Yaqi
   Sun, Lijuan
   Wang, Yi
   Zhao, Xiaoping
TI A dual-fluorescent whole-well imaging approach for screening active
   compounds against doxorubicin-induced cardiotoxicity from natural
   products
SO RSC ADVANCES
LA English
DT Article
ID OXIDATIVE STRESS; CARDIOMYOPATHY; MECHANISMS; TOXICITY
AB Doxorubicin (DOX) is an effective chemotherapy drug for various types of cancer. However, acute and chronic cardiotoxicity of DOX hamper its clinical application. There is a great demand for the discovery of drugs against DOX-induced cardiotoxicity. This paper proposed a dual fluorescence cellular imaging assay for screening active compounds against DOX toxicity. Whole-well fluorescence images of cells in 96-well microplates were automatically acquired and reconstructed by using a fluorescence microscope coupled with a computer-controlled moving stage. DOX-injured cardiomyocytes were labeled with two fluorescent probes, namely, fluorescein diacetate and Hoechst 33342, to determine cell viability and apoptosis. The linear range and sensitivity of the proposed approach were evaluated and validated by a known active compound, rutin. The proposed approach was also successfully applied in screening active compounds from a clinically used herbal medicine ZhenQiFuZheng granule (ZQFZ), which consisted of two herbs, Astragalus membranaceus (Fisch.) Bunge and Ligustrum lucidum. Five active components were found and were further analyzed by liquid chromatography coupled with mass spectrometry. Hydroxytyrosol, neonuezhenide, salidroside, and cimidahurinine attenuated DOX-induced cardiotoxicity in a dose-dependent manner with EC50 values of 198.0, 260.4, 621.7, and 45.79 mu M, respectively. Western blot results indicated that these active compounds protected against cardiotoxicity by decreasing reactive oxygen species (ROS) accumulation and downregulating apoptosis-related Bax/Bcl-2 proteins. The proposed approach is efficient in screening active compounds from natural products and other complex mixtures.
C1 [Chen, Yaqi; Sun, Lijuan; Wang, Yi] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China.
   [Zhao, Xiaoping] Zhejiang Chinese Med Univ, Coll Preclin Med, Hangzhou 310053, Zhejiang, Peoples R China.
C3 Zhejiang University; Zhejiang Chinese Medical University
RP Zhao, XP (corresponding author), Zhejiang Chinese Med Univ, Coll Preclin Med, Hangzhou 310053, Zhejiang, Peoples R China.
EM mysky@zju.edu.cn; zhaoxiaoping@zjtcm.net
RI Wang, Yi/C-2871-2013; Zhao, xiaoping/ABE-3908-2020
OI Wang, Yi/0000-0002-3676-9183; 
FU National Key Scientific and Technological Project of China
   [2012ZX09304007]
FX This study was supported by the National Key Scientific and
   Technological Project of China (No. 2012ZX09304007). The authors would
   like to acknowledge Dr Mark Sinnamon in MGH for the help in proofreading
   of the manuscript.
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NR 24
TC 3
Z9 3
U1 0
U2 37
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
EI 2046-2069
J9 RSC ADV
JI RSC Adv.
PY 2015
VL 5
IS 129
BP 106431
EP 106438
DI 10.1039/c5ra20887d
PG 8
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA CZ7IY
UT WOS:000367274300018
DA 2026-05-27
ER

PT J
AU Holla, V
   Hill, R
   Antosova, M
   Polakovic, M
AF Holla, Veronika
   Hill, Rhiannon
   Antosova, Monika
   Polakovic, Milan
TI Design of immobilized biocatalyst and optimal conditions for tyrosol
   β-galactoside production
SO BIOPROCESS AND BIOSYSTEMS ENGINEERING
LA English
DT Article
DE Immobilized beta-galactosidase; Reaction network; Substrate adsorption;
   Transgalactosylation; Tyrosol beta-galactoside
ID GLOBAL CEREBRAL-ISCHEMIA; OLIVE OIL; ENZYMATIC-SYNTHESIS; BIOACTIVE
   COMPOUND; PHENOLIC-COMPOUNDS; P-TYROSOL; HYDROXYTYROSOL; ANTIOXIDANT;
   SALIDROSIDE
AB Tyrosol beta-galactoside (TG) is a phenylethanoid glycoside with proven neuroprotective properties. This work deals with its biocatalytic production from tyrosol and lactose usingAspergillus oryzae beta-galactosidase in immobilized form. Six commercial carriers were examined to find the optimal biocatalyst. Besides standard biocatalyst performance characteristics, adsorption of the hydrophobic substrate on immobilization carrier matrices was also investigated. The adsorption of tyrosol was significant, but it did not have adverse effects on TG production. On the contrary, TG yield was improved for some biocatalysts. A biocatalyst prepared by covalent binding of beta-galactosidase on an epoxy-activated carrier was used for detailed investigation of the effect of reaction conditions on glycoside production. Temperature had a surprisingly weak effect on the overall process rate. A lactose concentration of 0.83 M was found to be optimal to enhance TG formation. The impact of tyrosol concentration was rather complex. This substrate caused inhibition of all reactions. Its concentration had a strong effect on the hydrolysis of lactose and all products. Higher tyrosol concentrations, 30-40 g/L, were favorable as pseudo-equilibrium concentrations of TG and galactooligosaccharide were reached. Repeated batch results revealed excellent operational stability of the biocatalyst.
C1 [Holla, Veronika; Hill, Rhiannon; Antosova, Monika; Polakovic, Milan] Slovak Univ Technol Bratislava, Dept Chem & Biochem Engn, Inst Chem & Environm Engn, Fac Chem & Food Technol, Radlinskeho 9, Bratislava 81237, Slovakia.
C3 Slovak University of Technology Bratislava
RP Polakovic, M (corresponding author), Slovak Univ Technol Bratislava, Dept Chem & Biochem Engn, Inst Chem & Environm Engn, Fac Chem & Food Technol, Radlinskeho 9, Bratislava 81237, Slovakia.
EM milan.polakovic@stuba.sk
RI Polakovic, Milan/A-1080-2015; Antosova, Monika/HFZ-9237-2022
OI Polakovic, Milan/0000-0003-0238-8996; Antosova,
   Monika/0000-0003-3671-9108
FU Agency of the Ministry of Education, Science, Research and Sport of the
   Slovak Republic for Structural Funds of EU [ITMS 26240220084]; Slovak
   Research and Development Agency [APVV-18-0188]; Slovak Grant Agency for
   Science [VEGA 1/0573/17]
FX This work was supported by Grants from the Agency of the Ministry of
   Education, Science, Research and Sport of the Slovak Republic for
   Structural Funds of EU (Grant number: ITMS 26240220084), Slovak Research
   and Development Agency (Grant number: APVV-18-0188), and the Slovak
   Grant Agency for Science (Grant number: VEGA 1/0573/17). Ms. Alessandra
   Basso from Purolite company is acknowledged for kindly providing their
   carriers. Dr. Vladimir Mastihuba is kindly acknowledged for providing
   the tyrosol-beta-d-galactoside standard.
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NR 40
TC 6
Z9 6
U1 0
U2 30
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1615-7591
EI 1615-7605
J9 BIOPROC BIOSYST ENG
JI Bioprocess. Biosyst. Eng.
PD JAN
PY 2021
VL 44
IS 1
BP 93
EP 101
DI 10.1007/s00449-020-02425-2
EA AUG 2020
PG 9
WC Biotechnology & Applied Microbiology; Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Engineering
GA PU3FZ
UT WOS:000567685800001
PM 32816074
DA 2026-05-27
ER

PT J
AU Yang, HY
   Duan, YK
   Wei, ZW
   Wu, YQ
   Zhang, CH
   Wu, WL
   Lyu, L
   Li, WL
AF Yang, Haiyan
   Duan, Yongkang
   Wei, Zhiwen
   Wu, Yaqiong
   Zhang, Chunhong
   Wu, Wenlong
   Lyu, Lianfei
   Li, Weilin
TI Integrated Physiological and Metabolomic Analyses Reveal the Differences
   in the Fruit Quality of the Blueberry Cultivated in Three Soilless
   Substrates
SO FOODS
LA English
DT Article
DE blueberry; substrate; soilless cultivation; fruit quality; metabolite
ID HIGHBUSH BLUEBERRIES; VACCINIUM-CORYMBOSUM; LIPID-PEROXIDATION;
   PLANT-TISSUES; STRAWBERRY; PHENOLICS; FIRMNESS; SYSTEM; SUGAR
AB With improving living standards, traditional blueberry planting modes cannot meet commercial demands, and blueberry cultivation with soilless substrate has become a popular solution in the blueberry industry. In this study, different soilless substrate treatments were found to markedly influence fruit appearance and intrinsic quality. The fruit in the 50:50 peat/pine bark (v/v) (FPB) treatment group had the maximum single fruit weight, largest vertical diameter, and brightest color, as well as the highest 1,1-diphenyl-2-picrylhydrazyl (DPPH) value, solid-acid ratio and anthocyanin content. The fruit in the 50:50 pine bark/rice husk (v/v) (FBR) treatment group had the highest total phenol and flavonoid levels, largest drip loss value, and lowest total pectin content and firmness value. Metabolomic analysis showed that flavonoid, carbohydrate, and carbohydrate conjugate, and amino acid, peptide, and analog levels were significantly different between groups. Fruit in the FPB group had the highest sucrose, D-fructose 1,6-bisphosphate, salidroside, tectorigenin, naringenin chalcone, trifolirhizin, and galangin contents. The increase in the relative expression of phenylalanine (Phe) promoted the synthesis of fruit polyphenols in the FBR group. Our results provide new insights into the effects of different substrates on the quality of blueberries and a reference for the soilless substrate cultivation of blueberries.
C1 [Yang, Haiyan; Wu, Yaqiong; Zhang, Chunhong; Wu, Wenlong; Lyu, Lianfei] Jiangsu Prov & Chinese Acad Sci, Inst Bot, Jiangsu Key Lab Res & Utilizat Plant Resources, Nanjing Bot Garden Mem Sun Yat Sen, Nanjing 210014, Peoples R China.
   [Duan, Yongkang; Wei, Zhiwen; Li, Weilin] Nanjing Forestry Univ, Coll Forestry, Nanjing 210037, Peoples R China.
C3 Institute of Botany, Jiangsu Province & Chinese Academy of Sciences;
   Chinese Academy of Sciences; Nanjing Forestry University
RP Wu, WL (corresponding author), Jiangsu Prov & Chinese Acad Sci, Inst Bot, Jiangsu Key Lab Res & Utilizat Plant Resources, Nanjing Bot Garden Mem Sun Yat Sen, Nanjing 210014, Peoples R China.; Li, WL (corresponding author), Nanjing Forestry Univ, Coll Forestry, Nanjing 210037, Peoples R China.
EM wuwenlong@jib.ac.cn; wlli@njfu.edu.cn
FU "JBGS" Project of Seed Industry Revitalization in Jiangsu Province
   [JBGS(2021)021]; Jiangsu Agricultural Science and Technology Innovation
   Fund Project [CX(21)3172]
FX This work was supported by the "JBGS" Project of Seed Industry
   Revitalization in Jiangsu Province (JBGS(2021)021) and Jiangsu
   Agricultural Science and Technology Innovation Fund Project (No.
   CX(21)3172).
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NR 58
TC 24
Z9 24
U1 5
U2 65
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2304-8158
J9 FOODS
JI Foods
PD DEC
PY 2022
VL 11
IS 24
AR 3965
DI 10.3390/foods11243965
PG 22
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 7G7VO
UT WOS:000902727000001
PM 36553707
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Kutluay, VM
   Makino, T
   Inoue, M
   Saracoglu, I
AF Kutluay, Vahap Murat
   Makino, Toshiaki
   Inoue, Makoto
   Saracoglu, Iclal
TI New knowledge about old drugs; a cardenolide type glycoside with
   cytotoxic effect and unusual secondary metabolites from Digitalis
   grandiflora Miller
SO FITOTERAPIA
LA English
DT Article
DE Digitalis species; Plantaginaceae; cardenolide glycosides;
   digigrandifloroside; antiproliferative activity
ID PHENYLETHANOID GLYCOSIDES; PHENOLIC GLYCOSIDES; PURPUREA L.; GLUCOSIDES;
   CYCLOHEXYLETHANOIDS; APOPTOSIS; CELLS
AB Phytochemical investigation of the aerial parts of Digitalis grandiflora Miller (Plantaginaceae) led to the isolation of an undescribed cardenolide type glycoside digigrandifloroside (1) along with five known compounds, rengyoside A (2), rengyoside B (3), cleroindicin A (4), salidroside (5), and cornoside (6), from its aqueous fraction of methanolic extract. Structures of the isolated compounds were determined by means of spectroscopic techniques. 1-6 were isolated for the first time from D. grandiflora. 2 and 3 are being reported for the first time from Digitalis genus and Plantaginaceae family with this study. This is the second report for occurrence of 4 from a Digitalis species, Cytotoxic activity of the aqueous fraction was also tested against HEp-2 (Human larynx epidermoid carcinoma) and HepG2 (Human hepatocellular carcinoma) cancer cell lines and L929 (Mouse fibroblast cell) non-cancerous cell line. Aqueous fraction showed stronger cytotoxicity on HEp-2 cells than HepG2. Therefore, the cytotoxic activity of 1, 2, 4, and 6 were tested against HEp-2 and L929 cell lines. 3 and 5 couldn't be tested due to their insufficient amount. 1 showed the highest cytotoxicity against HEp-2 cells with IC50 value 10.1 mu M when compared with the positive control, etoposide and 2-6 (IC50 of etoposide; 39.5 mu M).
C1 [Kutluay, Vahap Murat; Saracoglu, Iclal] Hacettepe Univ, Fac Pharm, Dept Pharmacognosy, TR-06100 Ankara, Turkey.
   [Makino, Toshiaki] Nagoya City Univ, Grad Sch Pharmaceut Sci, Dept Pharmacognosy, Nagoya, Aichi 4678603, Japan.
   [Inoue, Makoto] Aichi Gakuin Univ, Sch Pharm, Lab Med Resources, Nagoya, Aichi 4648650, Japan.
C3 Hacettepe University; Nagoya City University; Aichi Gakuin University
RP Kutluay, VM (corresponding author), Hacettepe Univ, Fac Pharm, Dept Pharmacognosy, TR-06100 Ankara, Turkey.
EM muratkutluay@hacettepe.edu.tr
RI KUTLUAY, VAHAP MURAT/J-1070-2013; SARACOGLU, ICLAL/AFT-9396-2022
OI KUTLUAY, VAHAP MURAT/0000-0003-4135-3497; SARACOGLU,
   ICLAL/0000-0003-0555-6262
FU Hacettepe University Scientific Research Project Coordination Unit
   [TDK-2016-12687]; Scientific and Technological Research Council of
   Turkey [TUBITAK 2214/A, 2211]
FX This work was supported by Hacettepe University Scientific Research
   Project Coordination Unit (grant number TDK-2016-12687). Vahap Murat
   Kutluay was supported by two research grants from The Scientific and
   Technological Research Council of Turkey (grant numbers TUBITAK 2214/A,
   2211).
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NR 34
TC 6
Z9 7
U1 1
U2 21
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0367-326X
EI 1873-6971
J9 FITOTERAPIA
JI Fitoterapia
PD APR
PY 2019
VL 134
BP 73
EP 80
DI 10.1016/j.fitote.2019.02.001
PG 8
WC Chemistry, Medicinal; Integrative & Complementary Medicine; Pharmacology
   & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Integrative & Complementary Medicine
GA HZ2WU
UT WOS:000468710300010
PM 30735707
DA 2026-05-27
ER

PT J
AU Du, YY
   Li, Q
   Liu, JJ
   Yin, YD
   Bi, KS
AF Du, Yiyang
   Li, Qing
   Liu, Jingjing
   Yin, Yidi
   Bi, Kaishun
TI Combinative method using multi-components quantitation by single
   reference standard and HPLC fingerprint for comprehensive evaluation of
   Rhodiola crenulata H.Ohba
SO ANALYTICAL METHODS
LA English
DT Article
ID PHENOLIC-COMPOUNDS; SALIDROSIDE; SACHALINENSIS; EXTRACTION; TYROSOL; L.
AB A combinative method using HPLC-DAD quantitative analysis and fingerprints were developed to evaluate the quality of Rhodiola crenulata H.Ohba (R. crenulata) from different origins. In this study, three phenolic compounds were first simultaneously determined by the single standard to determine multi-components (SSDMC) method. The chromatographic separation was performed on a Merck Purospher STAR RP-18 column (4.6 x 250 mm, 5 mu m) with a gradient-elution program within 28 min at 275 nm wavelength. The method has achieved desired specificity, linearity (r(2) >= 0.9999), precision, accuracy (95-105%), stability and robustness. Compared with the normal external standard method (ESM), this alternative method can be used for simultaneous determination of multiple indices effectively and accurately, and can resolve the problem of inadequate chemical standards. Moreover, the herbal chromatographic fingerprint was calculated using a similarity evaluation system and SPSS 19.0 software as a result of analysing all of the R. crenulata samples. The obtained data showed good repeatability and stability of the chromatographic fingerprint. The 15 R. crenulata samples from different origins were classified by hierarchical clustering analysis (HCA) and principal components analysis (PCA) according to the characteristic of common peaks. Moreover, similarity values were all more than 0.90. This study demonstrated that a combination of the chromatographic quantitative analysis and fingerprint offers an efficient way to quality consistency evaluation of R. crenulata.
C1 [Du, Yiyang; Li, Qing; Bi, Kaishun] Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China.
   [Liu, Jingjing; Yin, Yidi] Shenyang Pharmaceut Univ, Sch Chinese Mat Med, Shenyang 110016, Peoples R China.
   [Du, Yiyang; Li, Qing; Liu, Jingjing; Yin, Yidi; Bi, Kaishun] Shenyang Pharmaceut Univ, Natl & Local United Engn Lab Key Technol Chinese, Mat Medica Qual Control, Shenyang 110016, Peoples R China.
C3 Shenyang Pharmaceutical University; Shenyang Pharmaceutical University;
   Shenyang Pharmaceutical University
RP Bi, KS (corresponding author), Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China.
EM kaishunbi.syphu@gmail.com
RI Li, Qing/AAD-3286-2022
OI Li, Qing/0000-0003-3087-4692
FU Liaoning Innovative Research Team in University (LNIRT) [LT2013022]
FX This study was financially supported by Liaoning Innovative Research
   Team in University (LNIRT, Grant no. LT2013022).
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NR 26
TC 14
Z9 16
U1 1
U2 97
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 1759-9660
EI 1759-9679
J9 ANAL METHODS-UK
JI Anal. Methods
PD AUG 7
PY 2014
VL 6
IS 15
BP 5891
EP 5898
DI 10.1039/c4ay00422a
PG 8
WC Chemistry, Analytical; Food Science & Technology; Spectroscopy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Food Science & Technology; Spectroscopy
GA AL9NS
UT WOS:000339468600063
DA 2026-05-27
ER

PT J
AU Wang, Y
   Tao, HX
   Huang, HM
   Xiao, YQ
   Wu, XX
   Li, MX
   Shen, J
   Xiao, ZG
   Zhao, YS
   Du, FK
   Ji, HJ
   Chen, Y
   Cho, CH
   Wang, YT
   Wang, SP
   Wu, X
AF Wang, Yi
   Tao, Hongxun
   Huang, Huimin
   Xiao, Yaqin
   Wu, Xiaoxiao
   Li, Mingxing
   Shen, Jing
   Xiao, Zhangang
   Zhao, Yueshui
   Du, Fukan
   Ji, Huijiao
   Chen, Yu
   Cho, Chi Hin
   Wang, Yitao
   Wang, Shengpeng
   Wu, Xu
TI The dietary supplement Rhodiola crenulata extract alleviates
   dextran sulfate sodium-induced colitis in mice through
   anti-inflammation, mediating gut barrier integrity and reshaping the gut
   microbiome
SO FOOD & FUNCTION
LA English
DT Article
ID INDUCED ULCERATIVE-COLITIS; FECAL MICROBIOTA; AMELIORATING INFLAMMATION;
   INTESTINAL PERMEABILITY; TRANSPLANTATION; CELLS; PROTEOBACTERIA;
   PROLIFERATION; DISEASE; RATS
AB Rhodiola species are edible medicinal plants, which have been traditionally used in both Asia and Europe as an adaptogen, a tonic, an anti-depressant and anti-inflammatory supplement. However, whether it presents a therapeutic effect on colitis or not remains unknown. The aim of this study is to investigate the protective effect of a Rhodiola crenulata extract (RCE) on mice with DSS-induced colitis. RCE significantly alleviated the pathological abnormalities in colitic mice, including the correspondingly increased colon length, ameliorated colonic injury and reduced pro-inflammatory factors. The protective effect was similar to that of the positive control, 5-aminosalicylic acid. The DSS-induced epithelial apoptosis and maintained intestinal barrier function were attenuated by RCE through the upregulation of the level of tight junction proteins such as ZO-1 and occludin. Notably, RCE prevented gut dysbiosis in colitic mice by restoring the microbial richness and diversity, and decreasing the abundance of Proteobacteria phylum and opportunistic pathogenic Parasutterella and Staphylococcus, as well as increasing the abundance of beneficial microbes in Lactobacillus and Bifidobacterium, which were closely correlated with its protective effect against colitis. Meanwhile, chemical characterization of RCE was performed by UPLC-HR-MS to explain its material basis. A total of 63 compounds were identified, while the content of two bioactive ingredients (salidroside, 1.81%; rosavin, 0.034%) was determined.
C1 [Wang, Yi; Huang, Huimin; Wu, Xiaoxiao; Li, Mingxing; Shen, Jing; Xiao, Zhangang; Zhao, Yueshui; Du, Fukan; Ji, Huijiao; Chen, Yu; Cho, Chi Hin; Wu, Xu] Southwest Med Univ, Sch Pharm, Dept Pharmacol, Lab Mol Pharmacol, Luzhou, Sichuan, Peoples R China.
   [Wang, Yi; Huang, Huimin; Wu, Xiaoxiao; Li, Mingxing; Shen, Jing; Xiao, Zhangang; Zhao, Yueshui; Du, Fukan; Ji, Huijiao; Chen, Yu; Cho, Chi Hin; Wu, Xu] South Sichuan Inst Translat Med, Luzhou, Sichuan, Peoples R China.
   [Tao, Hongxun; Xiao, Yaqin; Wang, Yitao; Wang, Shengpeng] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China.
C3 Southwest Medical University; University of Macau
RP Wu, X (corresponding author), Southwest Med Univ, Sch Pharm, Dept Pharmacol, Lab Mol Pharmacol, Luzhou, Sichuan, Peoples R China.; Wu, X (corresponding author), South Sichuan Inst Translat Med, Luzhou, Sichuan, Peoples R China.; Wang, SP (corresponding author), Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China.
EM swang@um.edu.mo; wuxulz@126.com
RI WU, XU/GRY-2915-2022; Tao, Hongxun/D-6095-2016; Li,
   Mingxing/NKP-9481-2025; Chen, Yu/JBJ-5466-2023; Wang,
   Shengpeng/JOZ-1627-2023; Wang, Yitao/O-5184-2016
OI WU, XU/0000-0003-4555-0076; XIAO, Zhangang/0000-0003-3249-1118; Tao,
   Hongxun/0000-0001-8368-4572; 
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NR 61
TC 87
Z9 97
U1 4
U2 86
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD APR 7
PY 2021
VL 12
IS 7
BP 3142
EP 3158
DI 10.1039/d0fo03061a
PG 17
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA RM3XC
UT WOS:000639596100026
PM 33729231
DA 2026-05-27
ER

PT J
AU Chen, DQ
   Wu, J
   Li, P
AF Chen, Dan-Qian
   Wu, Jun
   Li, Ping
TI Therapeutic mechanism and clinical application of Chinese herbal
   medicine against diabetic kidney disease
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE diabetic kidney disease; Chinese herbal medicine; therapeutic mechanism;
   clinical application; metabolism regulation
ID OXIDATIVE STRESS; ABELMOSCHUS-MANIHOT; PODOCYTE INJURY; NEPHROPATHY;
   EFFICACY; RECEPTOR; ALBUMINURIA; SALIDROSIDE; SAFETY; CANAGLIFLOZIN
AB Diabetic kidney disease (DKD) is the major complications of type 1 and 2 diabetes, and is the predominant cause of chronic kidney disease and end-stage renal disease. The treatment of DKD normally consists of controlling blood glucose and improving kidney function. The blockade of renin-angiotensin-aldosterone system and the inhibition of sodium glucose cotransporter 2 (SGLT2) have become the first-line therapy of DKD, but such treatments have been difficult to effectively block continuous kidney function decline, eventually resulting in kidney failure and cardiovascular comorbidities. The complex mechanism of DKD highlights the importance of multiple therapeutic targets in treatment. Chinese herbal medicine (active compound, extract and formula) synergistically improves metabolism regulation, suppresses oxidative stress and inflammation, inhibits mitochondrial dysfunction, and regulates gut microbiota and related metabolism via modulating GLP-receptor, SGLT2, Sirt1/AMPK, AGE/RAGE, NF-kappa B, Nrf2, NLRP3, PGC-1 alpha, and PINK1/Parkin pathways. Clinical trials prove the reliable evidences for Chinese herbal medicine against DKD, but more efforts are still needed to ensure the efficacy and safety of Chinese herbal medicine. Additionally, the ideal combined therapy of Chinese herbal medicine and conventional medicine normally yields more favorable benefits on DKD treatment, laying the foundation for novel strategies to treat DKD.
C1 [Chen, Dan-Qian] China Japan Friendship Hosp, Dept Emergency, Beijing, Peoples R China.
   [Wu, Jun] Shandong Coll Tradit Chinese Med, Yantai, Shandong, Peoples R China.
   [Li, Ping] China Japan Friendship Hosp, Inst Clin Med Sci, Beijing Key Lab Immune Mediated Inflammatory Dis, Beijing, Peoples R China.
C3 China-Japan Friendship Hospital; Shandong University of Traditional
   Chinese Medicine; China-Japan Friendship Hospital
RP Chen, DQ (corresponding author), China Japan Friendship Hosp, Dept Emergency, Beijing, Peoples R China.; Li, P (corresponding author), China Japan Friendship Hosp, Inst Clin Med Sci, Beijing Key Lab Immune Mediated Inflammatory Dis, Beijing, Peoples R China.
EM chendanqian2013@163.com; lp8675@163.com
RI Chen, Dan-Qian/HCH-6571-2022
FU National Natural Science Foundation of China; China Postdoctoral Science
   Foundation;  [82174296];  [82104511];  [2021M693579]
FX Funding This study was supported by the National Natural Science
   Foundation of China (Grant Nos. 82174296, 82104511), and the Project
   funded by China Postdoctoral Science Foundation (Grant Nos.
   2021M693579).
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WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 6I3RT
UT WOS:000886046200001
PM 36408255
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Xing, N
   Qin, J
   Ren, DS
   Du, QY
   Li, YY
   Mi, J
   Zhang, FM
   Ai, L
   Zhang, SY
   Zhang, Y
   Wang, SH
AF Xing, Nan
   Qin, Jing
   Ren, Dongsheng
   Du, Qinyun
   Li, Yuying
   Mi, Jiao
   Zhang, Fengming
   Ai, Li
   Zhang, Sanyin
   Zhang, Yi
   Wang, Shaohui
TI Integrating UPLC-Q-Exactive Orbitrap/MS, network pharmacology and
   experimental validation to reveal the potential mechanism of Tibetan
   medicine Rhodiola granules in improving myocardial ischemia-reperfusion
   injury
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE UPLC-Q-exactive orbitrap; MS; Network pharmacology; Rhodiola granules;
   Myocardial ischemia-reperfusion injury; Experimental validation
ID SALIDROSIDE; INHIBITION
AB Ethnopharmacology relevance: Rhodiola granules (RG) is a traditional Tibetan medicine prescription that can be used to improve the symptoms of ischemia and hypoxia in cardiovascular and cerebrovascular diseases. How-ever, there is no report on its use to improve myocardial ischemia/reperfusion (I/R) injury, and its potential active ingredients and mechanism against myocardial ischemia/reperfusion (I/R) injury remain unclear.Aim of the study: This study aimed to reveal the potential bioactive components and underlying pharmacological mechanisms of RG in improving myocardial I/R injury through a comprehensive strategy. Materials and methods: UPLC-Q-Exactive Orbitrap/MS technology was used to analyze the chemical components of RG, the potential bioactive components and targets were tracked and predicted by the SwissADME and SwissTargetPrediction databases, and the core targets were predicted through the PPI network, as well the functions and pathways were determined by GO and KEGG analysis. In addition, the molecular docking and ligation of the anterior descending coronary artery-induced rat I/R models were experimentally validated.Results: A total of 37 ingredients were detected from RG, including nine flavones, ten flavonoid glycosides, one glycoside, eight organic acids, four amides, two nucleosides, one amino acid, and two other components. Among them, 15 chemical components, such as salidroside, morin, diosmetin, and gallic acid were identified as key active compounds. Ten core targets, including AKT1, VEGF, PTGS2, and STAT3, were discovered through the analysis of the PPI network constructed from 124 common potential targets. These possible targets were involved in the regulation of oxidative stress and HIF-1/VEGF/PI3K-Akt signaling pathways. Furthermore, molecular docking confirmed that the potential bioactive compounds in RG have good potential binding abilities to AKT1, VEGFA, PTGS2, STAT3, and HIF-1 alpha proteins. Then, the animal experiments showed that RG could significantly improve the cardiac function of I/R rats, reduce the size of myocardial infarction, improve the myocardial structure, and reduce the degree of myocardial fibrosis, inflammatory cell infiltration, and myocardial cell apoptosis rate in I/R rats. In addition, we also found that RG could decrease the concentration of AGE, Ox-LDL, MDA, MPO, XOD, SDH, Ca2+, and ROS, and increase the concentration of Trx, TrxR1, SOD, T-AOC, NO, ATP, Na+k+-ATPase, Ca2+-ATPase, and CCO. Moreover, RG could significantly down-regulate the expressions of Bax, Cleaved-caspase3, HIF-1 alpha, and PTGS2, as well up-regulate the expressions of Bcl-2, VEGFA, p-AKT1, and p-STAT3.Conclusion: In summary, we revealed for the first time the potential active ingredients and mechanisms of RG for myocardial I/R injury therapy through a comprehensive research strategy. RG may synergistically improve myocardial I/R injury through anti-inflammatory, regulating energy metabolism, and oxidative stress, improving I/R-induced myocardial apoptosis, which may be related to the HIF-1/VEGF/PI3K-Akt signaling pathway. Our study provides new insights into the clinical application of RG and also provides a reference for the development and mechanism research of other Tibetan medicine compound preparations.
C1 [Xing, Nan; Du, Qinyun] Chengdu Univ Tradit Chinese Med, Sch Pharm, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R China.
   [Qin, Jing; Ai, Li; Zhang, Yi; Wang, Shaohui] Chengdu Univ Tradit Chinese Med, Sch Ethn Med, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R China.
   [Ren, Dongsheng; Li, Yuying; Mi, Jiao; Zhang, Fengming] Tibet Rhodiola Pharmaceut Holding Co Ltd, Lasa, Peoples R China.
   [Zhang, Sanyin] Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Chengdu, Peoples R China.
   [Zhang, Sanyin] Chengdu Univ Tradit Chinese Med, Res Inst Integrated TCM & Western Med, Chengdu, Peoples R China.
   [Zhang, Yi; Wang, Shaohui] Chengdu Univ Tradit Chinese Med, State Key Lab Southwestern Chinese Med Resources, 1166 Liutai Ave, Chengdu 611137, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine; Chengdu University of Traditional
   Chinese Medicine; Chengdu University of Traditional Chinese Medicine;
   Chengdu University of Traditional Chinese Medicine
RP Zhang, SY (corresponding author), Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Chengdu, Peoples R China.; Zhang, Y; Wang, SH (corresponding author), Chengdu Univ Tradit Chinese Med, State Key Lab Southwestern Chinese Med Resources, 1166 Liutai Ave, Chengdu 611137, Peoples R China.
EM tcmzsy@cdutcm.edu.cn; zhangyi@cdutcm.edu.cn; winter9091@163.com
RI Qin, Jing/GWM-7542-2022; Wang, Shaohui/HKO-6774-2023
OI Wang, Shaohui/0000-0002-4203-4941
FU Key Research and Development Project of the Science & Technology
   Department of Sichuan Province [2020YFS0438]; Project of Science and
   Technology Department of Sichuan Province [2021YJ0112]; Project of
   Sichuan Provincial Administration of Traditional Chinese Medicine
   [2021MS017]; University (Chengdu University of TCM) enterprise (Tibet
   Rhodiola Pharmaceutical Holding Co. LTD) cooperation project
   [1052022040101B]
FX The study was supported by the Key Research and Development Project of
   the Science & Technology Department of Sichuan Province (2020YFS0438) ,
   the Project of Science and Technology Department of Sichuan Province
   (2021YJ0112) , the Project of Sichuan Provincial Administration of
   Traditional Chinese Medicine (2021MS017) and the University (Chengdu
   University of TCM) enterprise (Tibet Rhodiola Pharmaceutical Holding Co.
   LTD) cooperation project (1052022040101B) .
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NR 58
TC 29
Z9 34
U1 7
U2 72
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
EI 1872-7573
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD OCT 5
PY 2023
VL 314
AR 116572
DI 10.1016/j.jep.2023.116572
EA MAY 2023
PG 16
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA J1RS6
UT WOS:001007459100001
PM 37201662
DA 2026-05-27
ER

PT J
AU Erst, AA
   Kotsupiy, OV
   Erst, AS
   Kuznetsov, AA
AF Erst, Anna A.
   Kotsupiy, Olga V.
   Erst, Andrey S.
   Kuznetsov, Alexander A.
TI Individual Differences in Growth and in Accumulation of Secondary
   Metabolites in Rhodiola rosea Cultivated in Western Siberia
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE HPLC; roseroot; individual variability; rosavins; salidroside; tyrosol;
   flavonoids; hydroxybenzoic acids; catechins; Altai Mountains
ID PHENYLPROPENOID CONTENT; HARVEST SEASON; IONIC LIQUIDS; 4 FLAVONOIDS;
   PLANT-PART; L.; ROOTS; SEPARATION; ADAPTOGENS; EFFICACY
AB In this study, growth parameters of underground parts and concentrations of phenylpropanoids, phenylethanoids, flavonoids, hydroxybenzoic acids, and catechins in aqueous-ethanol extracts of 6-year-old cultivated plants of Rhodiola rosea (propagated in vitro) of Altai Mountain origin were analyzed, and differences in chemical composition among plant specimens and between plant parts (rhizome and root) were evaluated. High-performance liquid chromatography detected 13 phenolic compounds. Roots contained 1.28 times higher phenylethanoids levels (1273.72 mg/100 g) than rhizomes did. Overall, the concentration of phenylethanoids in underground organs was not high and ranged from 21.36 to 103.00 mg/100 g. High variation among R. rosea individual plants was noted both in growth characteristics and in levels of secondary metabolites under our cultivation conditions. It was found that concentrations of phenylpropanoids, phenylethanoids, and catechins significantly depend on the plant part analyzed (p & LE; 0.05). Specimen No. 4 is characterized by the highest concentration of rosavins (1230.99 mg/plant) and the lowest concentration of cinnamyl alcohol (62.87 mg/plant). Despite the wide range of values, all 10 tested specimens (underground part) met the minimum requirements of the United States Pharmacopeia (2015) for rosavins (0.3%) and of the Russia State Pharmacopoeia (2015) for the average level of rosavins (roots): (1%).
C1 [Erst, Anna A.; Kotsupiy, Olga V.; Erst, Andrey S.] Russian Acad Sci, Siberian Branch, Cent Siberian Bot Garden, Novosibirsk 630090, Russia.
   [Kuznetsov, Alexander A.] Tomsk State Univ, Lab Herbarium TK, Tomsk 634050, Russia.
C3 Central Siberian Botanical Garden; Russian Academy of Sciences; Siberian
   Branch of the Russian Academy of Sciences; Tomsk State University
RP Erst, AA (corresponding author), Russian Acad Sci, Siberian Branch, Cent Siberian Bot Garden, Novosibirsk 630090, Russia.
EM annaerst@yandex.ru; olnevaster@gmail.com; erst_andrew@yahoo.com;
   ys.tsu@mail.ru
RI Erst, Anna/D-4784-2015; Erst, Andrey/M-3444-2016; Kuznetsov,
   Alexander/D-5818-2014; Kotsupii, Olga/I-3732-2018
OI Erst, Anna/0000-0002-1980-4100; Erst, Andrey/0000-0002-4844-0254; 
FU CSBG SB RAS [AAAA-A21-121011290025-2, AAAA-A21-121011290024-5]; Tomsk
   State University Development Program
FX This research was supported by government-funded projects No.
   AAAA-A21-121011290025-2 and AAAA-A21-121011290024-5 of the CSBG SB RAS
   and Tomsk State University Development Program (Priority 2030).
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NR 63
TC 4
Z9 6
U1 7
U2 17
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUL
PY 2023
VL 24
IS 14
AR 11244
DI 10.3390/ijms241411244
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA N7HV7
UT WOS:001038687300001
PM 37511004
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhou, ZH
   Liu, WZZ
   Li, X
   Li, C
   An, R
   Liang, K
   Wang, XH
AF Zhou, Zehua
   Liu, Wangzhenzu
   Li, Xue
   Li, Chan
   An, Rui
   Liang, Kun
   Wang, Xinhong
TI Comparative pharmacokinetics of four major flavonoids in normal and
   chronic gastritis rats after oral administration of different
   combinations of Banxia Xiexin decoction
SO BIOMEDICAL CHROMATOGRAPHY
LA English
DT Article
DE Banxia Xiexin decoction; chronic gastritis; flavonoids; HPLC-TQ-MS; MS;
   pharmacokinetics
ID BIOACTIVE COMPONENTS; PLASMA; EXTRACTS; PROTECTS; DISEASE; MUCOSA;
   CYP2E1; INJURY
AB Chronic gastritis (CG) has become a major threat to human health. Banxia Xiexin Decoction (BXXXD) has been used clinically to treat gastritis by acting on the spleen and stomach for thousands of years. Baicalin, wogonoside, liquiritin and liquiritigenin are the main bioactive flavonoids of BXXXD. A rapid, sensitive and selective HPLC-triple quadrupole (TQ)-MS/MS method was developed to simultaneously quantify the four flavonoids in rat plasma in this study. With salidroside as internal standard (IS), plasma samples were extracted and separated on a Welch HPLC XB-C-18 column (2.1 x 50 mm, 1.8 mu m) using gradient elution. The optimized gradient of the mobile phase consisted of water (containing 0.1% formic acid) (A) and methanol (B) was used. Detection was implemented in multiple reaction monitoring mode with an electrospray negative ionization source. The comparative pharmacokinetics of four analytes in normal and CG rats after oral administration of BXXXD or its different compatibilities were first investigated. The results indicated that the pharmacokinetic behaviors of analytes were obviously changed in CG rats. From the comparison between the whole prescription group and the compatibility groups, it was found that the pharmacokinetic behavior of analytes also changed to some extent. The pharmacokinetic alterations of analytes might be due to the pathological conditions of CG.
C1 [Zhou, Zehua; Liu, Wangzhenzu; Li, Chan; An, Rui; Liang, Kun; Wang, Xinhong] Shanghai Univ Tradit Chinese Med, 1200 Cailun Rd, Shanghai 201203, Peoples R China.
   [Li, Xue] Shanghai Univ Tradit Chinese Med, LongHua Hosp, Shanghai, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Shanghai University
   of Traditional Chinese Medicine
RP Liang, K; Wang, XH (corresponding author), Shanghai Univ Tradit Chinese Med, 1200 Cailun Rd, Shanghai 201203, Peoples R China.
EM dolphin000000@163.com; wangxinh6020@126.com
OI Li, Xue/0000-0002-4090-1220
FU National Natural Science Foundation of China [81774183, 81803825]
FX National Natural Science Foundation of China, Grant/Award Numbers:
   81774183, 81803825
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NR 33
TC 6
Z9 7
U1 2
U2 22
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0269-3879
EI 1099-0801
J9 BIOMED CHROMATOGR
JI Biomed. Chromatogr.
PD NOV
PY 2022
VL 36
IS 11
AR e5458
DI 10.1002/bmc.5458
EA AUG 2022
PG 10
WC Biochemical Research Methods; Biochemistry & Molecular Biology;
   Chemistry, Analytical; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Pharmacology & Pharmacy
GA 5B0PR
UT WOS:000837038200001
PM 35883246
DA 2026-05-27
ER

PT J
AU Michels, B
   Zwaka, H
   Bartels, R
   Lushchak, O
   Franke, K
   Endres, T
   Fendt, M
   Song, I
   Bakr, M
   Budragchaa, T
   Westermann, B
   Mishra, D
   Eschbach, C
   Schreyer, S
   Lingnau, A
   Vahl, C
   Hilker, M
   Menzel, R
   Kähne, T
   Lessmann, V
   Dityatev, A
   Wessjohann, L
   Gerber, B
AF Michels, Birgit
   Zwaka, Hanna
   Bartels, Ruth
   Lushchak, Oleh
   Franke, Katrin
   Endres, Thomas
   Fendt, Markus
   Song, Inseon
   Bakr, May
   Budragchaa, Tuvshinjargal
   Westermann, Bernhard
   Mishra, Dushyant
   Eschbach, Claire
   Schreyer, Stefanie
   Lingnau, Annika
   Vahl, Caroline
   Hilker, Marike
   Menzel, Randolf
   Kaehne, Thilo
   Lessmann, Volkmar
   Dityatev, Alexander
   Wessjohann, Ludger
   Gerber, Bertram
TI Memory enhancement by ferulic acid ester across species
SO SCIENCE ADVANCES
LA English
DT Article
ID RHODIOLA-ROSEA; LIFE-SPAN; DROSOPHILA; BRUCHPILOT; PROTEIN; SALIDROSIDE;
   INHIBITION; MECHANISM; HONEYBEES; SYNAPSIN
AB Cognitive impairments can be devastating for quality of life, and thus, preventing or counteracting them is of great value. To this end, the present study exploits the potential of the plant Rhodiola rosea and identifies the constituent ferulic acid eicosyl ester [icosyl-(2E)-3-(4-hydroxy-3-methoxyphenyl)-prop-2-enoate (FAE-20)] as a memory enhancer. We show that food supplementation with dried root material from R. rosea dose-dependently improves odor-taste reward associative memory scores in larval Drosophila and prevents the age-related decline of this appetitive memory in adult flies. Task-relevant sensorimotor faculties remain unaltered. From a parallel approach, a list of candidate compounds has been derived, including R. rosea-derived FAE-20. Here, we show that both R. rosea-derived FAE-20 and synthetic FAE-20 are effective as memory enhancers in larval Drosophila. Synthetic FAE-20 also partially compensates for age-related memory decline in adult flies, as well as genetically induced early-onset loss of memory function in young flies. Furthermore, it increases excitability in mouse hippocampal CA1 neurons, leads to more stable context-shock aversive associative memory in young adult (3-month-old) mice, and increases memory scores in old (>2-year-old) mice. Given these effects, and given the utility of R. rosea-the plant from which we discovered FAE-20-as a memory enhancer, these results may hold potential for clinical applications.
C1 [Michels, Birgit; Zwaka, Hanna; Gerber, Bertram] Leibniz Inst Neurobiol, Dept Genet Learning & Memory, Magdeburg, Germany.
   [Zwaka, Hanna; Bartels, Ruth; Schreyer, Stefanie; Lingnau, Annika; Vahl, Caroline; Hilker, Marike; Menzel, Randolf] Free Univ Berlin, Inst Neurobiol, Berlin, Germany.
   [Lushchak, Oleh] Precarpathian Natl Univ, Dept Biochem, Ivano Frankivsk, Ukraine.
   [Franke, Katrin; Budragchaa, Tuvshinjargal; Westermann, Bernhard; Wessjohann, Ludger] Leibniz Inst Plant Biochem IPB, Dept Bioorgan Chem, Halle, Saale, Germany.
   [Endres, Thomas; Lessmann, Volkmar; Dityatev, Alexander] Otto Von Guericke Univ, Med Fac, Magdeburg, Germany.
   [Fendt, Markus] Otto Von Guericke Univ, Med Fac, Inst Pharmacol & Toxicol, Magdeburg, Germany.
   [Fendt, Markus; Lessmann, Volkmar; Dityatev, Alexander; Gerber, Bertram] Otto Von Guericke Univ, CBBS, Magdeburg, Germany.
   [Song, Inseon; Bakr, May; Dityatev, Alexander] German Ctr Neurodegenerat Dis DZNE, Mol Neuroplast Grp, Magdeburg, Germany.
   [Mishra, Dushyant; Eschbach, Claire] Univ Wurzburg, Bioctr Hubland, Dept Genet & Neurobiol, Wurzburg, Germany.
   [Kaehne, Thilo] Otto Von Guericke Univ, Inst Expt Internal Med, Magdeburg, Germany.
   [Gerber, Bertram] Otto Von Guericke Univ, Inst Biol, Magdeburg, Germany.
   [Zwaka, Hanna] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA.
   [Mishra, Dushyant] Univ Connecticut, Dept Physiol & Neurobiol, Storrs, CT 06269 USA.
   [Eschbach, Claire] Howard Hughes Med Inst, Janelia Res Campus,19700 Helix Dr, Ashburn, VA 20147 USA.
C3 Leibniz Association; Leibniz Institut fur Neurobiologie (LIN); Free
   University of Berlin; Ministry of Education & Science of Ukraine; Vasyl
   Stefanyk Carpathian National University; Leibniz Institut fur
   Pflanzenbiochemie; Otto von Guericke University; Otto von Guericke
   University; Otto von Guericke University; Helmholtz Association; German
   Center for Neurodegenerative Diseases (DZNE); University of Wurzburg;
   Otto von Guericke University; Otto von Guericke University; Harvard
   University; University of Connecticut; Howard Hughes Medical Institute
RP Michels, B; Gerber, B (corresponding author), Leibniz Inst Neurobiol, Dept Genet Learning & Memory, Magdeburg, Germany.; Wessjohann, L (corresponding author), Leibniz Inst Plant Biochem IPB, Dept Bioorgan Chem, Halle, Saale, Germany.; Gerber, B (corresponding author), Otto Von Guericke Univ, CBBS, Magdeburg, Germany.; Gerber, B (corresponding author), Otto Von Guericke Univ, Inst Biol, Magdeburg, Germany.
EM birgit.michels@lin-magdeburg.de; wessjohann@ipb-halle.de;
   bertram.gerber@lin-magdeburg.de
RI Bakr, May/LJL-8591-2024; Eschbach, Claire/AAA-9165-2022; Fendt,
   Markus/G-1888-2013; Dityatev, Alexander/A-4034-2008; Endres,
   Thomas/J-9393-2012; Mishra, Dushyant/P-4835-2018; Wessjohann, Ludger
   A/AAZ-3838-2021; Leßmann, Volkmar/E-8125-2013; Kähne, Thilo/E-4858-2012;
   Lushchak, Oleh/ABE-4061-2020
OI Bakr, May/0000-0001-8533-4867; Franke, Katrin/0000-0003-3043-3571;
   Schreyer, Stefanie/0000-0002-8331-0789; Fendt,
   Markus/0000-0002-3451-1226; Dityatev, Alexander/0000-0002-0472-0553;
   Endres, Thomas/0000-0003-4263-2922; Song, Inseon/0000-0003-1739-5566;
   Zwaka, Hanna/0000-0002-4469-5719; Mishra, Dushyant/0000-0003-3274-4349;
   Wessjohann, Ludger A/0000-0003-2060-8235; Leßmann,
   Volkmar/0000-0002-6863-323X; Lushchak, Oleh/0000-0002-4627-1987
FU Leibniz Institute for Neurobiology Magdeburg; German Center for
   Neurodegenerative Diseases (DZNE); Otto-von-Guericke-University
   Magdeburg; Journal of Experimental Biology Travelling Fellowship of The
   Company of Biologists; German-Israel Foundation Young Scientists'
   program; Leibniz Research Alliance Bioactive Compounds and Biotechnology
   program-Seed money; German Science Foundation (DFG) [CRC 554, CRC 779,
   CRC-TR 58, SPP 1392, ME 365/41-1]; German Science Foundation (DFG)
   (Heisenberg program) [GE 1091/4-1]; German Federal Ministry of Science
   and Technology (BMBF; Bernstein Focus Insect-inspired robotics);
   European Commission [MINIMAL FP7-618045]; EU Joint
   Program-Neurodegenerative Disease Research (JPND) project CircProt
   (BMBF); EU Joint Program-Neurodegenerative Disease Research (JPND)
   project CircProt (EU Horizon 2020 grant) [643417]; University of
   Wurzburg/Excellence Initiative Graduate School Life Sciences PhD
   fellowship; Wissenschaftsgemeinschaft Gottfried Wilhelm Leibniz (WGL); 
   [DFG-CRC779]
FX We received institutional support from the Leibniz Institute for
   Neurobiology Magdeburg, the Wissenschaftsgemeinschaft Gottfried Wilhelm
   Leibniz (WGL), the German Center for Neurodegenerative Diseases (DZNE),
   and the Otto-von-Guericke-University Magdeburg. Project support came
   from a Journal of Experimental Biology Travelling Fellowship of The
   Company of Biologists (to O.L.), the German-Israel Foundation Young
   Scientists' program, and the Leibniz Research Alliance Bioactive
   Compounds and Biotechnology program-Seed money (to B.M.). This study
   would not have been possible without the overhead money received through
   our grants from the German Science Foundation (DFG) (CRC 554, CRC 779,
   CRC-TR 58, SPP 1392, ME 365/41-1, Heisenberg program, and GE 1091/4-1),
   the German Federal Ministry of Science and Technology (BMBF; Bernstein
   Focus Insect-inspired robotics), and the European Commission (MINIMAL
   FP7-618045). T.E. and V.L. were supported by the EU Joint
   Program-Neurodegenerative Disease Research (JPND) project CircProt
   (jointly funded by BMBF and EU Horizon 2020 grant agreement no. 643417)
   and DFG-CRC779. C.E. was funded via a University of Wurzburg/Excellence
   Initiative Graduate School Life Sciences PhD fellowship.
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NR 74
TC 30
Z9 32
U1 1
U2 21
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
EI 2375-2548
J9 SCI ADV
JI Sci. Adv.
PD OCT
PY 2018
VL 4
IS 10
AR eaat6994
DI 10.1126/sciadv.aat6994
PG 18
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA GZ2MY
UT WOS:000449221200033
PM 30417089
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Xu, HX
   Li, XF
   Xin, X
   Mo, L
   Zou, YC
   Zhao, GL
AF Xu, Haixia
   Li, Xiaofeng
   Xin, Xuan
   Mo, Lan
   Zou, Yucong
   Zhao, Guanglei
TI Efficient Enzymatic Synthesis of Lipophilic Phenolic Glycoside Azelaic
   Acid Esters and Their Depigmenting Activity
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE biocatalysis; phenolic glycosides; azelaic acid; depigmentating activity
ID GALLATE EGCG DERIVATIVES; ACYLATED DERIVATIVES; DICARBOXYLIC-ACIDS;
   SALIDROSIDE; ANTIOXIDANT; RESVERATROL; PICEID; TYROSINASE; VIABILITY;
   HYDRATION
AB In this paper, an enzymatic route for synthesizing phenolic glycoside azelaic acid esters was successfully set up via lipase-catalyzed esterification and transesterification. Among the lipases tested, Candida antarctica lipase B (Novozyme 435) showed the highest activity in catalyzing esterification and Thermomyces lanuginosus (Lipozyme TLIM) gave the highest substrate conversion in catalyzing transesterification for the synthesis of ester. The addition of 4A molecular sieves into the reaction system is found to be an effective method for in situ absorption of the byproduct water and methanol, with which the substrate conversions of the enzymatic esterification and transesterification were 98.7 and 95.1%, respectively. Also, the main product ratios in transesterification were above 99.0% with lipozyme TLIM as a catalyst because the hydrolysis reaction was hindered. The results of the physical and biological properties indicate that all esters had higher Clog p values than their parent compounds. Also, the esters showed higher intracellular tyrosinase inhibitory and depigmentating activities than phenolic glycosides, azelaic acid (AA), and their physical mixtures due to their higher membrane penetration and tyrosinase inhibitory effects. In particular, piceid 6"-O-azelaic acid ester (PIA) showed the strongest inhibitory effect against melanin production. Its inhibitory rate was 77.4% at a concentration of 0.25 mM, about 4.2 times higher than that of arbutin (18.5%).
C1 [Xu, Haixia; Li, Xiaofeng; Xin, Xuan; Mo, Lan; Zou, Yucong] South China Univ Technol, Sch Food Sci & Engn, Guangzhou 510640, Peoples R China.
   [Zhao, Guanglei] South China Univ Technol, State Key Lab Pulp & Paper Engn, Guangzhou 510641, Peoples R China.
C3 South China University of Technology; South China University of
   Technology
RP Li, XF (corresponding author), South China Univ Technol, Sch Food Sci & Engn, Guangzhou 510640, Peoples R China.; Zhao, GL (corresponding author), South China Univ Technol, State Key Lab Pulp & Paper Engn, Guangzhou 510641, Peoples R China.
EM xflibio@scut.edu.cn; glzhao@scut.edu.cn
RI Zou, Yucong/JYQ-2603-2024; MO, LAN/LXW-3160-2024; Xin,
   Xuan/AAC-7034-2019
OI Zou, Yucong/0000-0003-2808-6611; Li, Xiao-feng/0000-0002-0144-6296; 
FU National Key R&D Program of China [2018YFC1602206]; National Natural
   Science Foundation of China [21978101, 21878107]; Science and Technology
   Program of Guangzhou, China [201803020031]
FX This work was financially supported by the National Key R&D Program of
   China (2018YFC1602206), the National Natural Science Foundation of China
   (21978101 and 21878107), and the Science and Technology Program of
   Guangzhou, China (201803020031).
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NR 59
TC 9
Z9 9
U1 3
U2 83
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD NOV 10
PY 2021
VL 69
IS 44
BP 13102
EP 13112
DI 10.1021/acs.jafc.1c03092
EA OCT 2021
PG 11
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA WX0RM
UT WOS:000718312300017
PM 34705451
DA 2026-05-27
ER

PT J
AU Chen, T
   Gong, XS
AF Chen, Tao
   Gong, Xusheng
TI Global Research Trend Analysis of Osmanthus fragrans Based on
   Bibliometrix
SO MOBILE INFORMATION SYSTEMS
LA English
DT Article
ID VOLATILE COMPOUNDS; FUNCTIONAL-CHARACTERIZATION; ANTIOXIDANT CAPACITIES;
   ESSENTIAL OIL; FLOWERS; EXPRESSION; CULTIVARS; EXTRACT; PHOTOSYNTHESIS;
   IDENTIFICATION
AB Osmanthus fragrans is the ornamental and practical excellent garden tree featured with greening, beautification, and fragrance in one, and has been domesticated in China for 2500 years. Besides, an increasing number of papers on O. fragrans have been published so far, but these contributions have not been analyzed comprehensively. Considering that, in this research, a bibliometric methodology is adopted on documents related to O. fragrans obtained from the WoS database. The study demonstrated the main countries and institutions in terms of this field. Among them, the Chinese research on O. fragrans is in a leading position in the world. Regarding the specialization, the institution ranking is led by the Nanjing Forestry University, Henan University, and Zhejiang University. Apart from that, analysis on the keywords also highlighted the lines of research associated with plant functionality (e.g., antioxidant, antifungal activity, and anti-inflammatory activities), natural products (e.g., carotenoids, aroma, flavonoids, essential oils, phenylethanoid glycosides, and salidroside), and molecular biology (e.g., genetic diversity, transcription factors, and phylogeny). The results from this study also revealed that there is a lack of research on the production mechanism of floral fragrance and the flower color regulation mechanism in O. fragrans. Moreover, the aroma and flower color are gradually developing into the main areas of research on O. fragrans. It is also expected that future research in this field will focus on biochemistry and biomolecules.
C1 [Chen, Tao; Gong, Xusheng] Hubei Univ Sci & Technol, Sch Nucl Technol & Chem Ef Biol, Hubei Engn Res Ctr Fragrant Plants, Xianning 437100, Hubei, Peoples R China.
   [Chen, Tao] China Shenzhen Green Century Environm Technol Co, Shenzhen 518000, Guangdong, Peoples R China.
C3 Hubei University of Science & Technology
RP Gong, XS (corresponding author), Hubei Univ Sci & Technol, Sch Nucl Technol & Chem Ef Biol, Hubei Engn Res Ctr Fragrant Plants, Xianning 437100, Hubei, Peoples R China.
EM gxs5339@stu.hubu.edu.cn
OI Gong, Xusheng/0000-0002-7040-4663
FU Hubei University of Science and Technology Research and Development Fund
   [BK202001]
FX This study was supported by Hubei University of Science and Technology
   Research and Development Fund (BK202001).
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NR 76
TC 8
Z9 10
U1 1
U2 39
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1574-017X
EI 1875-905X
J9 MOB INF SYST
JI Mob. Inf. Syst.
PD JUL 15
PY 2022
VL 2022
AR 4091962
DI 10.1155/2022/4091962
PG 10
WC Computer Science, Information Systems; Telecommunications
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Computer Science; Telecommunications
GA 5R7DY
UT WOS:000874667900007
OA hybrid
DA 2026-05-27
ER

PT J
AU Choi, HG
   Lee, HD
   Kim, SH
   Na, MK
   Kim, JA
   Lee, SH
AF Choi, Hyun Gyu
   Lee, Hwa Dong
   Kim, Sang Hyun
   Na, Min Kyun
   Kim, Jeong Ah
   Lee, Seung Ho
TI Phenolic Glycosides from Lindera obtusiloba and their
   Anti-allergic Inflammatory Activities
SO NATURAL PRODUCT COMMUNICATIONS
LA English
DT Article
DE Lindera obtusiloba; Phenolic glucoside; Anti-allergic inflammatory;
   TNF-alpha; IL-6
ID SUPPRESSION; BLUME
AB Eight phenolic glycosides, tachioside (1), isotachioside (2), koaburaside (3), 2,6-dimethoxy-4-hydroxyphenyl-1-O-beta-D-glucopyranoside (4), 4,6-dihydroxy-2-methoxyphenyl-1-O-beta-D-glucopyranoside (5), a mixture of erigeside C (6a) and salidroside (6b), and 6-hydroxyphenyl)-1-O-beta-D-glucopyranoside (7) were isolated from the stems of Lindera obtusiloba Blume. The structures of the isolates were determined by H-1-, C-13-NMR, COSY, HMQC, and HMBC spectroscopy. To evaluate their anti-allergic inflammatory activities, the inhibitory effects of isolates (1-7) on histamine release and on the gene expressions of tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 were examined using human mast cells; previous studies have reported that TNF-alpha and IL-6 release from mast cells is positively related to the severity of allergic symptoms. Of the tested compounds, koaburaside (3), 2,6-dimethoxy-4-hydroxyphenyl-1-O-beta-D-glucopyranoside (4), and (6-hydroxyphenyl)-1-O-beta-D-glucopyranoside (7) suppressed histamine release from mast cells as compared with gallic acid (positive control). In particular, 6-hydroxyphenyl)-1-O-beta-D-glucopyranoside (7) attenuated the gene expressions of the proinflammatory cytokines TNF-alpha and IL-6 in human mast cells. Our results support the notion that phenolic glycosides isolated from L. obtusiloba inhibit mast-cell-derived allergic inflammation, histamine, and proinflammatory cytokines.
C1 [Choi, Hyun Gyu; Lee, Hwa Dong; Lee, Seung Ho] Yeungnam Univ, Coll Pharm, Gyongsan 712749, Gyungbuk, South Korea.
   [Kim, Sang Hyun] Kyungpook Natl Univ, Sch Med, Taegu 702701, South Korea.
   [Na, Min Kyun] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea.
   [Kim, Jeong Ah] Kyungpook Natl Univ, Pharmaceut Sci Res Inst, Coll Pharm, Taegu 702701, South Korea.
C3 Yeungnam University; Kyungpook National University (KNU); Chungnam
   National University; Kyungpook National University (KNU)
RP Kim, JA (corresponding author), Kyungpook Natl Univ, Pharmaceut Sci Res Inst, Coll Pharm, Taegu 702701, South Korea.
EM jkim6923@knu.ac.kr; seungho@yu.ac.kr
RI Na, MinKyun/K-4873-2013; Kim, Sang-Hyun/J-5402-2012
OI Na, MinKyun/0000-0002-4865-6506; 
FU Yeungnam University
FX This research was supported by the Yeungnam University research grants
   in 2010.
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NR 17
TC 17
Z9 21
U1 1
U2 9
PU NATURAL PRODUCTS INC
PI WESTERVILLE
PA 7963 ANDERSON PARK LN, WESTERVILLE, OH 43081 USA
SN 1934-578X
J9 NAT PROD COMMUN
JI Nat. Prod. Commun.
PD FEB
PY 2013
VL 8
IS 2
BP 181
EP 182
PG 2
WC Chemistry, Medicinal; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology
GA 095XT
UT WOS:000315369000012
PM 23513723
DA 2026-05-27
ER

PT J
AU Jiang, WJ
   Guo, HJ
   Su, DY
   Xu, HJ
   Gu, HM
   Hao, K
AF Jiang, Wenjiao
   Guo, Huijie
   Su, Dongyuan
   Xu, Hongjiang
   Gu, Hongmei
   Hao, Kun
TI Ameliorative effect of Magnesium Isoglycyrrhizinate on hepatic
   encephalopathy by Epirubicin
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE Magnesium Isoglycyrrhizinate; Epirubicin; Hepatic encephalopathy
ID ISCHEMIA-REPERFUSION INJURY; ACUTE LUNG INJURY; OXIDATIVE STRESS;
   LIVER-INJURY; MICE; APOPTOSIS; CELLS; INFLAMMATION; SALIDROSIDE;
   ACTIVATION
AB Background: The purpose of the present study was to evaluate the protective effect of Magnesium Isoglycyrrhizinate (MI) on Epirubicin (EPI)-induced hepatic encephalopathy (HE) and explore its underlying mechanism.
   Methods: Mice were divided randomly into groups for treatments as follows: control group, EPI group (Model group), EPI + MI (25, 50 mg/kg) group. Morris water maze test were conducted to evaluate the spatial learning and memory ability. The serum and hippocampus levels of oxidative stress or inflammation were uncovered with the detection of superoxide dismutase (SOD), malondialdehyde (MDA), and pro-inflammatory cytokines IL-1 beta, IL-6, TNF-alpha).
   Results: As a result, treatment with MI effectively ameliorated the EPI-induced decline in the ability of spatial learning and memory. MI also significantly relieved the severity of oxidative stress or inflammation in serum and hippocampus, which was accompanied with regulating liver functional parameters. Western blot data demonstrated that administration of MI could regulate the redox-related expressions of Txnip, Trx, Nrf2, HO-1, p-I kappa B-alpha, p-NF-kappa B, Caspase-3, Caspase-9, Bax and Bcl-2 in EPI-stimulated hepatic encephalopathy (HE). And the potency of MI treatments on Nrf2, NF-kappa B expression was also confirmed with immunohistochemical analysis.
   Conclusions: Taken together, the protective effect of Magnesium Isoglycyrrhizinate on EN-induced hepatic encephalopathy might be mediated via the Dmip/Nrf2/NF-kappa B signaling pathway.
C1 [Jiang, Wenjiao; Guo, Huijie; Hao, Kun] China Pharmaceut Univ, Key Lab Drug Metab & Pharmacokinet, Nanjing 210009, Jiangsu, Peoples R China.
   [Su, Dongyuan] Nanjing Med Univ, Key Lab Neurodegenerat Jiangsu Prov, Nanjing 210009, Jiangsu, Peoples R China.
   [Xu, Hongjiang; Gu, Hongmei] Chia Tai Tianqing Pharmaceut Grp Co Ltd, Nanjing 210023, Jiangsu, Peoples R China.
C3 China Pharmaceutical University; Nanjing Medical University
RP Hao, K (corresponding author), China Pharmaceut Univ, Key Lab Drug Metab & Pharmacokinet, Nanjing 210009, Jiangsu, Peoples R China.
EM cpu_haokun@aliyun.com
FU Natural Science Foundation of China [81773826]; Drug Innovation Major
   Project [2018ZX09711001]; 111 Incubation Project [BC2018024]; Chia Tai
   Tianqing Pharmaceutical Group Co., Ltd., Nanjing, China
FX This research was supported by Natural Science Foundation of China
   (grants 81773826), The Drug Innovation Major Project (grants
   2018ZX09711001), 111 Incubation Project (BC2018024) and Chia Tai
   Tianqing Pharmaceutical Group Co., Ltd., Nanjing, China.
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NR 44
TC 19
Z9 21
U1 0
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD OCT
PY 2019
VL 75
AR 105774
DI 10.1016/j.intimp.2019.105774
PG 11
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA JC0VV
UT WOS:000488998800032
PM 31351363
DA 2026-05-27
ER

PT J
AU Lee, SY
   Lai, FY
   Shi, LS
   Chou, YC
   Yen, IC
   Chang, TC
AF Lee, Shih-Yu
   Lai, Feng-Yi
   Shi, Li-Shian
   Chou, Yu-Ching
   Yen, I-Chuan
   Chang, Tsu-Chung
TI Rhodiola crenulata extract suppresses hepatic
   gluconeogenesis via activation of the AMPK pathway
SO PHYTOMEDICINE
LA English
DT Article
DE Rhodiola crenulata; Hepatic gluconeogenesis; AMPK
ID ISOLATED NEUROGLIAL CELLS; PROTEIN-KINASE; METABOLIC SYNDROME; SIGNALING
   PATHWAY; GLUCOSE-UPTAKE; IDENTIFICATION; SALIDROSIDE; INHIBITION;
   EXPRESSION; LIVER
AB Background: Rhodiola, a popular herb, has been used for treating high altitude sicknesses, depression, fatigue, and diabetes. However, the detailed mechanisms by which Rhodiola crenulata functions in the liver need further clarification.
   Purpose: The current study was designed to examine the effects of Rhodiola crenulata root extract (RCE) on hepatic glucose production.
   Methods: Human hepatoma HepG2 cells were treated with RCE for 6 h. Glucose production, the expression level of p-AMPK, and the expression of key gluconeogenic genes were measured. The effects of RCE were also studied in Sprague-Dawley (SD) rats. The efficacy and underlying mechanism of RCE in the liver were examined.
   Results: RCE significantly suppressed glucose production and gluconeogenic gene expression in HepG2 cells while activating the AMPK signaling pathway. Interestingly, RCE-suppressed hepatic gluconeogenesis was eliminated by an AMPK-specific inhibitor, but not by the PI3K/AKT-specific inhibitor. In addition, oral administration of RCE significantly increased phosphoiylated AMPK levels and inhibited gluconeogenic gene expression in the rat liver. Furthermore, RCE treatment also decreased plasma glucose concentration in rats.
   Conclusion: We present in vitro and in vivo evidence that RCE might exert the glucose-lowering effect partly by inhibiting hepatic gluconeogenesis through activating the AMPK signaling pathway. These findings provide evidence that Rhodiola crenulata may be helpful for the management of type II diabetes. (C) 2015 Elsevier GmbH. All rights reserved.
C1 [Lee, Shih-Yu] Natl Def Med Ctr, Inst Aerosp Undersea Med, Taipei 114, Taiwan.
   [Lai, Feng-Yi; Chang, Tsu-Chung] Natl Def Med Ctr, Dept Biochem, Taipei 114, Taiwan.
   [Shi, Li-Shian] Natl Def Med Ctr, Dept Biotechnol, Taipei 114, Taiwan.
   [Chou, Yu-Ching] Natl Def Med Ctr, Sch Publ Hlth, Taipei 114, Taiwan.
   [Yen, I-Chuan] Natl Def Med Ctr, Sch Pharm, Taipei 114, Taiwan.
   [Chang, Tsu-Chung] China Med Univ, Grad Inst Basic Med Sci, Taichung, Taiwan.
C3 National Defense Medical University; National Defense Medical
   University; National Defense Medical University; National Defense
   Medical University; National Defense Medical University; China Medical
   University Taiwan
RP Chang, TC (corresponding author), Natl Def Med Ctr, Dept Biochem, POB 90048-501, Taipei 114, Taiwan.
EM leeshihyuno1@mail.ndmctsgh.edu.tw; rocodo29@hotmail.com;
   lsshi@sunws.nfu.edu.tw; trishow@mail.ndmctsgh.edu.tw;
   yenichuan@mail.ndmctsgh.edu.tw; tcchang@mail.ndmctsgh.edu.tw
RI Lee, Shih-Yu/AAO-4110-2020
OI Lee, Shih-Yu/0000-0002-4713-6410
FU Ministry of Science and Technology [NSC 101-2320-B-016-010-MY2, MOST
   103-2320-B-016-005]; Ministry of National Defense, Taipei, Taiwan, ROC
   [MAB-102-9, 103-M019, MAB-103-M078]
FX The study was supported by grants from the Ministry of Science and
   Technology (NSC 101-2320-B-016-010-MY2 and MOST 103-2320-B-016-005 to
   T.-C. Chang) and the Ministry of National Defense (MAB-102-9 and
   103-M019 to T.-C. Chang; MAB-103-M078 to S.-Y. Lee), Taipei, Taiwan,
   ROC.
CR Chang W-L, 2013, Adaptive Med, V5, P181, DOI DOI 10.4247/AM.2013.ABD068
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NR 29
TC 39
Z9 50
U1 2
U2 57
PU ELSEVIER GMBH, URBAN & FISCHER VERLAG
PI JENA
PA OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD APR 15
PY 2015
VL 22
IS 4
BP 477
EP 486
DI 10.1016/j.phymed.2015.01.016
PG 10
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA CG8KL
UT WOS:000353556300008
PM 25925970
DA 2026-05-27
ER

PT J
AU Zeng, X
   Wang, JW
   Xu, QY
   Deng, CD
   Yi, X
   Wang, S
   Yao, L
   Xiang, W
AF Zeng, Xin
   Wang, Jianwei
   Xu, Qinyi
   Deng, Chengdan
   Yi, Xi
   Wang, Shang
   Yao, Ling
   Xiang, Wei
TI Ultra-High-Performance Liquid Chromatography-Tandem Mass Spectrometry
   and Network Pharmacology Reveal the Mechanisms of Rhodiola
   crenulata in Improving Non-Alcoholic Fatty Liver Disease
SO CURRENT ISSUES IN MOLECULAR BIOLOGY
LA English
DT Article
DE <italic>Rhodiola crenulata</italic>; non-alcoholic fatty liver disease;
   UHPLC-MS; network pharmacology; molecular docking; molecular dynamics
   simulations
ID METABOLITES; SERUM; ROOT
AB Rhodiola crenulata (RC) is a traditional herb and functional food that has demonstrated beneficial effects in improving physical function, enhancing work capacity, alleviating fatigue, and preventing altitude sickness. Additionally, RC has shown promising effects in the treatment of non-alcoholic fatty liver disease (NAFLD), although its specific bioactive components and underlying mechanisms remain unclear. In this study, ultra-high-performance liquid chromatography-mass spectrometry (UHPLC-MS) combined with network pharmacology was employed to identify six potential bioactive compounds from the serum of rats treated with RC-Salidroside, Tyrosol, Crenulatin, Catechin gallate, Eriodictyol, and Rhodiooctanoside-that may contribute to its therapeutic effects on NAFLD. The efficacy of these compounds in improving NAFLD was assessed in vitro using HepG2 cells exposed to Palmitic acid (PA), and it was found that Catechin gallate exhibited a significant effect in reducing lipid accumulation in HepG2 cells. Furthermore, based on network pharmacology predictions, molecular docking studies suggested that the primary targets of Catechin gallate in alleviating fatty liver might include ABCB1, DYRK1A, PGD, and FUT4. Molecular dynamics simulations revealed stable binding interactions between Catechin gallate and these four target proteins. This study clarifies the material basis of RC in the treatment of NAFLD and provides a theoretical foundation for the application of RC and Catechin gallate as functional additives for the management of NAFLD.
C1 [Zeng, Xin; Wang, Jianwei; Deng, Chengdan; Wang, Shang; Yao, Ling; Xiang, Wei] Chongqing Univ Chinese Med, Chongqing Key Lab Tradit Chinese Med Prevent & Cur, Chongqing 402760, Peoples R China.
   [Zeng, Xin; Wang, Jianwei; Xu, Qinyi; Yi, Xi] Chongqing Med Univ, Coll Tradit Chinese Med, Chongqing 400016, Peoples R China.
C3 Chongqing Medical University
RP Yao, L; Xiang, W (corresponding author), Chongqing Univ Chinese Med, Chongqing Key Lab Tradit Chinese Med Prevent & Cur, Chongqing 402760, Peoples R China.
EM zeng_xin928@163.com; wjwcq68@163.com; zsjxqy@126.com; dcd0843@163.com;
   yeexien@163.com; wangshang0227@sina.com; yaoling@cqctcm.edu.cn;
   xiangwei@cqctcm.edu.cn
RI /ABX-1228-2022; Xu, Qinyi/AAK-2484-2020; wei, xiang/NQE-8378-2025
FU Chongqing traditional Chinese Medicine inheritance and Innovation team
   project; Scientific and Technological Research Program of Chongqing
   Municipal Education Commission [KJQN202315109, KJQN202215112,
   KJZD-M202215101]; Bayu Qihuang Scholar Project, Science and Technology
   research project of Chongqing Education Commission; 
   [2023090006KJZX2022WJW008]
FX This research was funded by Chongqing traditional Chinese Medicine
   inheritance and Innovation team project (Grant No.
   2023090006KJZX2022WJW008), Scientific and Technological Research Program
   of Chongqing Municipal Education Commission (Grant No. KJQN202315109,
   KJQN202215112 and KJZD-M202215101) and Bayu Qihuang Scholar Project,
   Science and Technology research project of Chongqing Education
   Commission.
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NR 52
TC 1
Z9 1
U1 12
U2 19
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1467-3037
EI 1467-3045
J9 CURR ISSUES MOL BIOL
JI Curr. Issues Mol. Biol.
PD MAY 1
PY 2025
VL 47
IS 5
AR 324
DI 10.3390/cimb47050324
PG 19
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 3AI1E
UT WOS:001495585000001
PM 40699724
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Esmaealzadeh, N
   Iranpanah, A
   Sarris, J
   Rahimi, R
AF Esmaealzadeh, Niusha
   Iranpanah, Amin
   Sarris, Jerome
   Rahimi, Roja
TI A literature review of the studies concerning selected plant-derived
   adaptogens and their general function in body with a focus on animal
   studies
SO PHYTOMEDICINE
LA English
DT Review
DE Adaptogen; Herb; Phytochemical; Stress; Fatigue; Cognition
ID ROSEA L. EXTRACT; STRESS-INDUCED PERTURBATIONS; INDUCED OXIDATIVE
   STRESS; C-H-R; RHODIOLA-ROSEA; WITHANIA-SOMNIFERA; DOUBLE-BLIND;
   BACOPA-MONNIERA; LIPID-PEROXIDATION; ALCOHOLIC EXTRACT
AB Background: Adaptogens are generally referred to the substances, mostly found in plants, which non-specifically increase resilience and chances of survival by activation of signaling pathways in affected cells.
   Purpose: This literature review was conducted to summarize the investigation, until March 2021, on selected adaptogenic plants and plant-derived substances.
   Study Design: Electronic databases were searched (up to March 2021) for in vitro and animal studies, as well as clinical trials. Moreover, all modes of action connected with the adaptogenic effects of plants and phytochemicals were collected.
   Methods: The search of relevant studies was performed within electronic databases including Scopus, Science Direct, PubMed, and Cochrane library. The most important keywords were adaptogen, plant, phytochemical, and plant-derived.
   Results: The most investigated medicinal herbs for their adaptogenic activity are Eleutherococcus senticosus, Panax ginseng, Withania somnifera, Schisandra chinensis, and Rhodiola spp., salidroside, ginsenosides, andrographolide, methyl jasmonate, cucurbitacin R, dichotosin, and dichotosininare are phytochemicals that have shown a considerable adaptogenic activity. Phytochemicals that have been demonstrated adaptogenic properties mainly belong to flavonoids, terpenoids, and phenylpropanoid glycosides.
   Conclusion: It is concluded that the main modes of action of the selected adaptogenic plants are stress modulatory, antioxidant, anti-fatigue, and physical endurance enhancement. Other properties were nootropic, immunomodulatory, cardiovascular, and radioprotective activities.
C1 [Esmaealzadeh, Niusha; Rahimi, Roja] Univ Tehran Med Sci, Sch Persian Med, Dept Tradit Pharm, POB 1417653761, Tehran, Iran.
   [Esmaealzadeh, Niusha; Rahimi, Roja] Universal Sci Educ & Res Network USERN, PhytoPharmacol Interest Grp PPIG, Tehran, Iran.
   [Iranpanah, Amin] Kermanshah Univ Med Sci, Pharmaceut Sci Res Ctr, Hlth Inst, Kermanshah, Iran.
   [Iranpanah, Amin] Universal Sci Educ & Res Network USERN, Kermanshah USERN Off, Kermanshah, Iran.
   [Sarris, Jerome] Western Sydney Univ, NICM Hlth Res Inst, Westmead, NSW, Australia.
   [Sarris, Jerome] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Melbourne, Vic, Australia.
   [Sarris, Jerome] Univ Melbourne, Dept Psychiat, Professorial Unit, Melbourne Clin, Melbourne, Vic, Australia.
C3 Tehran University of Medical Sciences; Universal Scientific Education &
   Research Network (USERN); Kermanshah University of Medical Sciences;
   Universal Scientific Education & Research Network (USERN); Western
   Sydney University; Florey Institute of Neuroscience & Mental Health;
   University of Melbourne; University of Melbourne
RP Rahimi, R (corresponding author), Univ Tehran Med Sci, Sch Persian Med, Dept Tradit Pharm, POB 1417653761, Tehran, Iran.
EM rojarahimi@gmail.com
RI ; Rahimi, Roja/O-3230-2016; Esmaealzadeh, Niusha/AAD-5056-2021
OI Iranpanah, Amin/0000-0001-8422-6151; Rahimi, Roja/0000-0001-8637-4350;
   Esmaealzadeh, Niusha/0000-0002-6352-8916
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NR 162
TC 25
Z9 36
U1 4
U2 26
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD OCT
PY 2022
VL 105
AR 154354
DI 10.1016/j.phymed.2022.154354
EA AUG 2022
PG 17
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA 4U1HS
UT WOS:000858554400005
PM 35932607
DA 2026-05-27
ER

PT J
AU Qian, XS
   Zhu, MH
   Qian, WC
   Song, JX
AF Qian, Xuesong
   Zhu, Minghui
   Qian, Weichun
   Song, Jiaxian
TI Vitamin D attenuates myocardial ischemia-reperfusion injury by
   inhibiting inflammation via suppressing the RhoA/ROCK/NF-B pathway
SO BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
LA English
DT Article
DE Cardiovascular diseases; Inflammation; Myocardial ischemia-reperfusion;
   RhoA; ROCK; NF-kappa B; Vitamin D
ID D-RECEPTOR ACTIVATION; KINASE; SALIDROSIDE; RATS; APOPTOSIS; PROTECTS;
   HEART; MICE
AB The aim of this study was to investigate the protective effects of vitamin D (VD) against myocardial ischemia-reperfusion (I/R) injury in hearts. An I/R injury model was induced by left coronary artery ligation in Sprague-Dawley rats (in vivo) and Langendorff perfusion of isolated hearts (in vitro). The infarction areas were determined by triphenyltetrazolium chloride (TTC) staining. Changes in the ST segment, cardiac function, lactate dehydrogenase (LDH) activity, creatine kinase (CK) activity, inflammatory cytokine (interleukin-6 (IL-6), IL-1 beta, and tumor necrosis factor-alpha (TNF-alpha)) levels and the RhoA/ROCK/NF-B pathway were tested in rats with I/R injury treated with or without VD. VD notably alleviated myocardial injury with decreased infarction areas and had a restorative effect on cardiac function, which was specifically manifested as a restored ST segment, increased myocardial contractility and increased coronary blood flow in the isolated hearts. The levels of CK and LDH were also suppressed by VD. In addition, VD significantly decreased the expression of inflammatory cytokines in rat sera and isolated hearts. The RhoA/ROCK/NF-kappa B pathway in I/R-injured rats was also obviously inhibited with VD treatment. The present study demonstrates that VD plays a protective role against myocardial injury by inhibiting inflammation through repressing the RhoA/ROCK/NF-kappa B pathway.
C1 [Qian, Xuesong; Zhu, Minghui; Song, Jiaxian] Soochow Univ, Dept Cardiol, Affiliated Zhangjiagang Hosp, Suzhou 215600, Peoples R China.
   [Qian, Weichun] Nanjing Med Univ, Nanjing Hosp 1, Dept Cardiol, Nanjing, Jiangsu, Peoples R China.
C3 Soochow University - China; Nanjing Medical University
RP Song, JX (corresponding author), Soochow Univ, Dept Cardiol, Affiliated Zhangjiagang Hosp, Suzhou 215600, Peoples R China.
EM jiaxsong66@126.com
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NR 28
TC 34
Z9 38
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0885-4513
EI 1470-8744
J9 BIOTECHNOL APPL BIOC
JI Biotechnol. Appl. Biochem.
PD SEP
PY 2019
VL 66
IS 5
BP 850
EP 857
DI 10.1002/bab.1797
EA JUL 2019
PG 8
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
GA JF2NH
UT WOS:000477430700001
PM 31245891
DA 2026-05-27
ER

PT J
AU Chung, IM
   Kim, EH
   Kim, JJ
   Moon, HI
AF Chung, Ill-Min
   Kim, Eun-Hye
   Kim, Jong-Jin
   Moon, Hyung-In
TI Inhibition effects of the classical pathway complement of isolated
   compounds from Quercus glauca
SO HUMAN & EXPERIMENTAL TOXICOLOGY
LA English
DT Article
DE Quercus species; Quercus glauca; anticomplement activity; galloyl
   derivatives; classical pathway
ID JUGLANS-MANDSHURICA; CONSTITUENTS; CASTALAGIN; TANNINS; STEM
AB Species of the Quercus species is an evergreen broadleaf tree found not only in Korea but also in China, Taiwan, and Japan. Quercus species is the most commonly occurring plant among the 50 native species of the family Fagaceae in Korea, China, and Taiwan. Quercus species have been used for diarrhea, dysentery, dermatitis, and hemorrhagia in Korean folk medicine. The present study evaluated the anticomplement effect of constituents from Quercus species (Fagaceae) in classical pathway complement system. We have evaluated leaves of five species of the Quercus genus with regard to its anticomplement activity and have identified its active principles following activity-guided isolation. Bioactivity-guided fractionation of the 80% methanol extracts of the stem barks of Quercus glauca Thunberg has led to the isolation of galloyl derivatives, displaying high anticomplement activity. Four galloyl derivatives isolated from the leaves of Q. glauca, namely 6'-O-galloyl salidroside (1), methyl gallate (2), 1,2,3,6-tetragalloylglucose (3), and 1,2,6-trigalloylglucose (4). 1, 2, 3 and 4 showed inhibitory activity against complement system with 50% inhibitory concentrations (IC(50)) values of 224 mu M, 362.4 mu M, 32.3 mu M, and 138.3 mu M. Among the compounds tested, 3 showed the most potent anticomplement activity (IC(50), 32.3 mu M). This is the first report of the isolation and anticomplement activity from Q. glauca.
C1 [Moon, Hyung-In] Dongguk Univ, Cardiovasc Med Res Ctr, Coll Korean Med, Gyeong Ju 780714, South Korea.
   [Chung, Ill-Min; Kim, Eun-Hye] Konkuk Univ, Dept Appl Life Sci, Seoul, South Korea.
   [Kim, Jong-Jin] Konkuk Univ, Dept Environm Sci, Seoul, South Korea.
   Wonkwang Univ, Inam Neurosci Res Ctr, Sanbon Med Ctr, Kyonggi Do 435040, South Korea.
C3 Dongguk University; Konkuk University; Konkuk University; Wonkwang
   University
RP Moon, HI (corresponding author), Dongguk Univ, Cardiovasc Med Res Ctr, Coll Korean Med, Gyeong Ju 780714, South Korea.
EM himun68@gmail.com
OI Chung, Il-Moon/0000-0003-0163-7305
FU Korea Forest Service [SI20909 L080000]
FX This study was carried out with the support of 'Forest Science &
   Technology Projects (Project No. SI20909 L080000)' provided by Korea
   Forest Service.
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NR 12
TC 1
Z9 3
U1 0
U2 3
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0960-3271
J9 HUM EXP TOXICOL
JI Hum. Exp. Toxicol.
PD SEP
PY 2011
VL 30
IS 9
BP 1415
EP 1419
DI 10.1177/0960327110390067
PG 5
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA 814QY
UT WOS:000294473300031
PM 21078772
DA 2026-05-27
ER

PT J
AU Li, Y
   Yuan, MJ
   Zhang, ZY
   Pei, NC
AF Li, Yong
   Yuan, Meng-Jie
   Zhang, Zi-Yan
   Pei, Nan-Cai
TI The gap-free genome assembly and multi-omics analyses illustrate the
   evolutionary history and the synthesis of medicinal components of
   Ligustrum lucidum
SO PLANT JOURNAL
LA English
DT Article
DE <italic>Ligustrum lucidum</italic>; medicinal component; Oleaceae;
   specnuezhenide; telomere to telomere
ID DE-NOVO IDENTIFICATION; RNA-SEQ DATA; OLEANOLIC ACID; GERANIOL
   10-HYDROXYLASE; GENE; ALIGNMENT; TRANSCRIPTOME; ACCURATE; PROGRAM;
   FRUCTUS
AB Ligustrum lucidum, an important ornamental and medicinal plant in the Oleaceae family, has become a globally notorious invasive species because of its high adaptability. However, the lack of a high quality genome has hindered the understanding of the genetic basis for its broad adaptability and the mechanisms of its medicinal component synthesis. In this study, we successfully assembled a gap free telomere to telomere genome of L. lucidum. Through the reconstruction of the phylogenetic tree, we presented evidence that Jasmineae diverged from Oleaceae earlier than Forsythieae, which challenges the existing phylogenetic relationships within Oleaceae. Comparative genomics has found that two rounds of gene family expansions in L. lucidum significantly increased the number of genes related to its biotic and abiotic stress resistances, which may lay the genetic foundation for its broad adaptability. Among the L. lucidum fruits from January to March in our investigation, the results of metabolome show that March may be the optimal harvesting time. By integrating genomic, transcriptomic, and metabolomic data, we identified candidate genes involved in the synthesis of compounds, such as specnuezhenide, salidroside, and oleanolic acid. This study provides valuable genomic resources for comparative genomics studies within Oleaceae and for the genetic research of L. lucidum.
C1 [Li, Yong; Yuan, Meng-Jie; Zhang, Zi-Yan] Inner Mongolia Normal Univ, Coll Life Sci & Technol, Hohhot, Peoples R China.
   [Pei, Nan-Cai] Chinese Acad Forestry, Res Inst Trop Forestry, Guangzhou, Peoples R China.
C3 Inner Mongolia Normal University; Chinese Academy of Forestry; Research
   Institute of Tropical Forestry, CAF
RP Pei, NC (corresponding author), Chinese Acad Forestry, Res Inst Trop Forestry, Guangzhou, Peoples R China.
EM nancai.pei@gmail.com
OI Li, Yong/0009-0004-0672-9334
FU Natural Science Foundation of Inner Mongolia Autonomous Region
   [32360307]; National Natural Science Foundation of China
   [CAFYBB2023MB017]; Fundamental Research Funds of CAF [2024A1515011484];
   Guangdong Basic and Applied Basic Research Foundation [2023MS03031];
   Natural Science Foundation of Inner Mongolia [3211002406]; Inner
   Mongolia Grassland Talents Project; Inner Mongolia Normal University
   Introduces High-Level Talents Funds
FX This work was supported by National Natural Science Foundation of China
   (32360307), Fundamental Research Funds of CAF (CAFYBB2023MB017),
   Guangdong Basic and Applied Basic Research Foundation (2024A1515011484),
   Natural Science Foundation of Inner Mongolia (2023MS03031), Inner
   Mongolia Grassland Talents Project (3211002406), Inner Mongolia Normal
   University Introduces High-Level Talents Funds.
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NR 112
TC 2
Z9 2
U1 6
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0960-7412
EI 1365-313X
J9 PLANT J
JI Plant J.
PD FEB 22
PY 2025
VL 121
IS 4
AR e70029
DI 10.1111/tpj.70029
PG 17
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences
GA X8I8T
UT WOS:001427725700001
PM 39985810
DA 2026-05-27
ER

PT J
AU Feng, Z
   Song, J
   Lin, CH
   Wu, SY
   Wang, Y
   Hui, QY
   Pan, YT
   Zou, YM
   Zeng, CF
   Guo, JB
   Pei, YL
AF Feng, Zheng
   Song, Jia
   Lin, Chenghong
   Wu, Siyu
   Wang, Yu
   Hui, Qingyuan
   Pan, Yinting
   Zou, Yiman
   Zeng, Chaofeng
   Guo, Jinbiao
   Pei, Yangli
TI Enhancing porcine oocyte quality and embryo development through natural
   antioxidants
SO THERIOGENOLOGY
LA English
DT Article
DE Porcine; Quality of oocyte; Oxidative stress; Antioxidants; Embryo
   development
ID OXIDATIVE STRESS; IN-VITRO; COMPETENCE; MATURATION; SUPPLEMENTATION;
   FERTILIZATION; METABOLISM; RELEVANCE; SIRTUINS; IMPROVES
AB During fetal development, primordial oocytes maintain their developmental potential through a ROS-minimizing metabolic mechanism. Maturation increases ROS levels, causing stress and damage, which are countered by in vivo antioxidants. In vitro maturation (IVM) worsens this due to fewer antioxidant presence and medium factors. To address this, we evaluated the effects of incorporating various natural antioxidants in the porcine oocyte IVM media. Our findings revealed that 10 mu M Dendrobine (DEN), 1 mu M Polydatin (PD), 20 mu M Limonin (LIM), and 25 mu M Nobiletin (NOB) significantly improved the first polar body extrusion rates (p < 0.05), reduced ROS, and increased GSH levels. Individual addition of 100 <mu>g/mL Lycium barbarum polysaccharides (LBP), 0.1 mu M Kaempferol (KAE), 250 mu M Salidroside (SAL), 10 mu M Curcumin (CUR), DEN, PD, LIM, and NOB to the porcine IVM system showed that KAE, LIM, NOB, and LBP treatments yielded the most favorable results. At the gene level, LIM, LBP, and NOB were found to upregulate the expression levels of GPX1, SIRT1, and TFAM, while downregulating Caspase3 and increasing the BCL2/BAX ratio. The inclusion of LIM, NOB, and LBP, either alone or in combination, into the IVM media effectively alleviated oxidative stress in porcine oocytes, decreased cell apoptosis, preserved mitochondrial membrane potential, and enhanced the blastocyst rate. These results offer valuable insights for optimizing the porcine oocyte IVM culture system.
C1 [Feng, Zheng; Song, Jia; Lin, Chenghong; Wu, Siyu; Wang, Yu; Hui, Qingyuan; Pan, Yinting; Guo, Jinbiao; Pei, Yangli] Foshan Univ, Guangdong Higher Educ Inst, Sch Life Sci & Engn, Guangdong Prov Key Lab Anim Mol Design & Precise B, Foshan 528225, Peoples R China.
   [Zou, Yiman; Zeng, Chaofeng] Nanhai Dist Agr Law Enforcement Supervis Brigade, Foshan 528225, Peoples R China.
C3 Foshan University
RP Guo, JB; Pei, YL (corresponding author), Foshan Univ, Guangdong Higher Educ Inst, Sch Life Sci & Engn, Guangdong Prov Key Lab Anim Mol Design & Precise B, Foshan 528225, Peoples R China.
EM guojinbiao@fosu.edu.cn; peiyangli@163.com
RI zeng, chaofeng/AAG-6983-2021; Pei, Yangli/IAP-4522-2023
OI feng, zheng/0000-0002-0759-1312; Pei, Yangli/0000-0002-6631-2985
FU Guangdong Basic and Applied Basic Research Foundation [2020B1515120016];
   Key Technologies R & D Program of Guangdong Province [2022B0202090001]
FX This work was funded by Guangdong Basic and Applied Basic Research
   Foundation (2020B1515120016) , Key Technologies R & D Program of
   Guangdong Province (2022B0202090001) .
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NR 44
TC 10
Z9 12
U1 1
U2 8
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0093-691X
EI 1879-3231
J9 THERIOGENOLOGY
JI Theriogenology
PD JAN 15
PY 2025
VL 232
BP 96
EP 108
DI 10.1016/j.theriogenology.2024.11.002
EA NOV 2024
PG 13
WC Reproductive Biology; Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Reproductive Biology; Veterinary Sciences
GA M6K5S
UT WOS:001358605700001
PM 39536623
DA 2026-05-27
ER

PT J
AU Nawaz, M
   Pan, JK
   Liu, H
   Umer, MJ
   Liu, JC
   Yang, WB
   Lv, ZZ
   Zhang, Q
   Jiao, ZG
AF Nawaz, Muhammad
   Pan, Junkun
   Liu, Hui
   Umer, Muhammad Jawad
   Liu, Jiechao
   Yang, Wenbo
   Lv, Zhenzhen
   Zhang, Qiang
   Jiao, Zhonggao
TI Integrated evaluation of antifungal activity of pomegranate peel
   polyphenols against a diverse range of postharvest fruit pathogens
SO BIORESOURCES AND BIOPROCESSING
LA English
DT Article
DE Pomegranate peel; Polyphenols; Antifungal activity; Fruit; Postharvest
   pathogens
ID P-COUMARIC ACID; PHENOLIC-COMPOUNDS; SWEET CHERRIES; BY-PRODUCTS;
   IN-VITRO; ANTIOXIDANT; EXTRACT; IDENTIFICATION; MECHANISM
AB The search for safe, natural antimicrobial agents has received significant attention for controlling postharvest diseases in fruits. This study evaluated the antifungal activity of pomegranate peel extracts (PPE) against 9 pathogenic fungi by different methods. Additionally, the key antifungal polyphenol compounds were identified. Results revealed that the n-hexane partitioned fraction of ethanolic extract exhibited the highest inhibition efficacy. A total 36 polyphenols, including 10 newly discovered compounds in pomegranate peel were recognized. Among these, 9 specific polyphenols were found to be relatively abundant in the n-hexane fraction, highlighting their potential as primary antifungal agents. Notably, the newly identified polyphenol compound nobiletin demonstrated the strongest inhibitory effects against Colletotrichum gloeosporioides, Rhizopus stolonifer and Aspergillus niger with inhibition diameters of 12.2, 12.0, and 12.5 mm, respectively. Salidroside exhibited significant antifungal activity against Monilinia fructicola and A. niger (inhibition diameters > 12.0 mm). Furthermore, cinnamic acid that was enriched in hexane fraction, showed the highest inhibitory zones against Alternaria alternata, C. gloeosporioides and Botryosphaeria dothidea (11.8 similar to 12.7 mm). Caffeic acid and protocatechuic acid both displayed the lowest minimum inhibitory concentration (MIC) on Penicillium expansum. The study demonstrated the potential of PPE, particularly the n-hexane fraction, as a broad-spectrum natural antifungal agent for postharvest disease management.
C1 [Nawaz, Muhammad; Pan, Junkun; Liu, Hui; Liu, Jiechao; Yang, Wenbo; Lv, Zhenzhen; Zhang, Qiang; Jiao, Zhonggao] Chinese Acad Agr Sci, Zhengzhou Fruit Res Inst, Zhengzhou 450009, Henan, Peoples R China.
   [Liu, Hui] Chinese Acad Agr Sci, Zhongyuan Res Ctr, Xinxiang 453000, Henan, Peoples R China.
   [Umer, Muhammad Jawad] Guangdong Acad Agr Sci, Peanut Sub Ctr Natl Ctr Oilseed Crops Improvement, Crops Res Inst, Guangdong Prov Key Lab Crop Genet Improvement, Guangzhou 510640, Guangdong, Peoples R China.
C3 Chinese Academy of Agricultural Sciences; Zhengzhou Fruit Research
   Institute, CAAS; Chinese Academy of Agricultural Sciences; Guangdong
   Academy of Agricultural Sciences
RP Liu, H; Jiao, ZG (corresponding author), Chinese Acad Agr Sci, Zhengzhou Fruit Res Inst, Zhengzhou 450009, Henan, Peoples R China.; Liu, H (corresponding author), Chinese Acad Agr Sci, Zhongyuan Res Ctr, Xinxiang 453000, Henan, Peoples R China.
EM liuhui@caas.cn; jiaozhonggao@caas.cn
RI UMER, MUHAMMAD JAWAD/AAC-3617-2021
OI Jiao, Zhonggao/0000-0002-2439-7706
FU National Key Research and Development Program
FX Not applicable.
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NR 63
TC 13
Z9 13
U1 11
U2 31
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
EI 2197-4365
J9 BIORESOUR BIOPROCESS
JI Bioresour. Bioprocess.
PD APR 15
PY 2025
VL 12
IS 1
AR 34
DI 10.1186/s40643-025-00874-9
PG 15
WC Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology
GA 1JT7D
UT WOS:001466687400001
PM 40229518
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Raczynska, A
   Szmigiel-Merena, B
   Brzezinska-Rodak, M
   Klimek-Ochab, M
   Zymanczyk-Duda, E
AF Raczynska, Agnieszka
   Szmigiel-Merena, Beata
   Brzezinska-Rodak, Malgorzata
   Klimek-Ochab, Magdalena
   Zymanczyk-Duda, Ewa
TI Fungal Biocatalysis in Stereoselective Oxidation of 2-Phenylethanol
SO SYMMETRY-BASEL
LA English
DT Article
DE biotransformation; 2-phenylethanol; fungi; <italic>Beauveria
   bassiana</italic>; <italic>Beauveria brongniartii</italic>;
   <italic>Rhizopus arrhizus</italic>;
   (<italic>R</italic>)-1-phenylethane-1,2-diol; tyrosol
ID (R)-(-)-MANDELIC ACID; SECONDARY METABOLISM; RHIZOPUS-ARRHIZUS;
   (R)-1-PHENYL-1,2-ETHANEDIOL; STYRENE; BIOTRANSFORMATIONS; SALIDROSIDE;
   REDUCTION; TOLERANCE; SYSTEM
AB Three fungal strains were employed for the stereoselective oxidation of the cheap and commercially available substrate 2-phenylethanol, which resulted in chiral building blocks being received. The whole-cell biocatalysts were as follows: Beauveria bassiana DSM 1344, Beauveria brongniartii DSM 6651, and Rhizopus arrhizus DSM 1185. The main product of Beauveria bassiana bioconversion was 1-phenylethane-1,2-diol, obtained, depending on the form of the biocatalyst, as an R-enantiomer (e.g., 99.9%) with fresh biomass application or as a racemic mixture in cases of immobilization in agar-agar. The best and most innovative results for the synthesis of the R-enantiomer of diol were received under precisely defined conditions as a result of a scaling study conducted on an automatic batch reactor. This is a pioneering result, since, in previous studies, fresh mycelium of Aspergillus niger resulted in this product being received as the (S) enantiomer. Also, the use of Rhizopus arrhizus DSM 1185 (immobilized in polyurethane foams) presented important results, as the bioconversion of phenyl ethanol led, indeed, to the racemic mixture of 1-phenylethane-1,2-diol but was accompanied by a noticeable tyrosol synthesis, which had not been reported previously.
C1 [Raczynska, Agnieszka; Szmigiel-Merena, Beata; Brzezinska-Rodak, Malgorzata; Klimek-Ochab, Magdalena; Zymanczyk-Duda, Ewa] Wroclaw Univ Sci & Technol, Fac Chem, Dept Biochem Mol Biol & Biotechnol, Wybrzeze Stanislawa Wyspianskiego 27, PL-50370 Wroclaw, Poland.
C3 Wroclaw University of Science & Technology
RP Raczynska, A; Zymanczyk-Duda, E (corresponding author), Wroclaw Univ Sci & Technol, Fac Chem, Dept Biochem Mol Biol & Biotechnol, Wybrzeze Stanislawa Wyspianskiego 27, PL-50370 Wroclaw, Poland.
EM agnieszka.raczynska@pwr.edu.pl; b.szmigiel.wsf@wp.pl;
   malgorzata.brzezinska-rodak@pwr.edu.pl;
   magdalena.klimek-ochab@pwr.edu.pl; ewa.zymanczyk-duda@pwr.edu.pl
RI ; Klimek-Ochab, Magdalena/ABH-5180-2020
OI Żymańczyk-Duda, Ewa/0000-0002-1806-8244; Klimek-Ochab,
   Magdalena/0000-0002-9521-5770; Brzezińska-Rodak,
   Małgorzata/0000-0003-2944-2833; Szmigiel-Merena,
   Beata/0000-0002-6516-0908
FU Wroclaw University of Science and Technology [50SD/0068/24]
FX The work was supported in part by the project Minigrants for doctoral
   students at the Wroclaw University of Science and Technology, number
   50SD/0068/24.
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NR 61
TC 2
Z9 2
U1 4
U2 9
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2073-8994
J9 SYMMETRY-BASEL
JI Symmetry-Basel
PD JAN
PY 2025
VL 17
IS 1
AR 17
DI 10.3390/sym17010017
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA T5F4T
UT WOS:001405260000001
OA gold
DA 2026-05-27
ER

PT J
AU Chen, SM
   Li, XC
   Zeng, JY
   Cai, RX
   Li, CH
   Chen, CB
AF Chen, Shaoman
   Li, Xican
   Zeng, Jingyuan
   Cai, Rongxin
   Li, Chunhou
   Chen, Chuanbing
TI Library-based UHPLC-Q-exactive-orbitrap-MS putative identification of
   isomeric and non-isomeric bioactives from Zibushengfa Tablet and
   pharmacopeia quality-marker chemistry
SO JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
LA English
DT Article
DE Adulteration; Chinese medicine; isomers distinction; putative
   identification; quality-control
ID PERFORMANCE LIQUID-CHROMATOGRAPHY; RAT PLASMA; AMENTOFLAVONE PROTECTS;
   PHENOLIC CONSTITUENTS; REHMANNIAE-RADIX; METABOLITES; MS/MS;
   DERIVATIVES; MECHANISM
AB Zibushengfa Tablet is a widely consumed traditional Chinese medicine (TCM) prescription. However, its main bioactives remain unclear and its pharmacopeia quality-marker (Q-marker) is poorly characterized nowadays. The present study analyzed its lyophilized aqueous powder using ultra-high-performance liquid chromatography-quadrupole-orbitrap mass spectrometry. Through comparison with authentic standards in the library, 46 bioactives were putatively identified, including quinic acid, D-gluconic acid, gallic acid, protocatechuic acid, 5-caffeoylquinic acid, L-tryptophan, salidroside, (+)-catechin hydrate, caffeic acid, cryptochlorogenic acid, mangiferin, ferulic acid, myricetin-3-O-galactoside, 2,3,5,4'-tetrahydroxystilbene-2-O-glucoside, forsythoside B, myricitrin, rutin, hyperoside, acteoside, 3,4-dicaffeoylquinic acid, myricetin, senkyunolide A, isochlorogenic acid C, quercitrin, (+)-epipinoresinol, quercetin, biochanin A, calycosin, luteolin, wedelolactone, calycosin-7-O-glucoside, chrysoeriol, trans-cinnamic acid, formononetin, chrysin, 3,3',4',5,6,7,8-heptamethoxyflavone, Z-ligustilide, amentoflavone, tangeretin, hinokiflavone, emodin, physcion, linoleic acid, stearic acid, palmitic acid, and palmitic acid ethyl ester. Of these, four pairs of isomers were successfully differentiated using the newly established library-filtering strategy. On this basis, senkyunolide A, amentoflavone, quercetin, quercitrin, and wedelolactone are preliminarily suggested as additional quality-markers for the consideration by Pharmacopeia Committee, to prevent the possible adulterate.
C1 [Chen, Shaoman; Li, Xican; Zeng, Jingyuan; Cai, Rongxin; Li, Chunhou; Chen, Chuanbing] Guangzhou Univ Chinese Med, Sch Chinese Herbal Med, Guangzhou, Peoples R China.
   [Cai, Rongxin] Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Chengdu University of
   Traditional Chinese Medicine
RP Li, XC (corresponding author), Guangzhou Univ Chinese Med, Sch Chinese Herbal Med, Guangzhou, Peoples R China.
EM lixican@126.com
RI /R-7344-2019
OI Cai, Rongxin/0009-0004-0582-7055
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NR 82
TC 12
Z9 12
U1 5
U2 23
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1082-6076
EI 1520-572X
J9 J LIQ CHROMATOGR R T
JI J. Liq. Chromatogr. Relat. Technol.
PD SEP 15
PY 2023
VL 46
IS 6-10
BP 153
EP 167
DI 10.1080/10826076.2023.2223640
EA JUN 2023
PG 15
WC Biochemical Research Methods; Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA M1ND5
UT WOS:001013715300001
DA 2026-05-27
ER

PT J
AU Wu, F
   Zhang, BJ
   Zhang, Y
   Zhao, T
   Wang, Y
   Tian, XG
   Sun, CP
   Fang, BJ
   Huo, XK
   Ma, XC
AF Wu, Fan
   Zhang, Baojing
   Zhang, Yu
   Zhao, Ting
   Wang, Yan
   Tian, Xiangge
   Sun, Chengpeng
   Fang, Bangjiang
   Huo, Xiaokui
   Ma, Xiaochi
TI Simultaneous Determination of Ten Active Components From Jinhongtang
   Granule in Rat Plasma by LC-MS/MS and its Application to a Comparative
   Pharmacokinetic Study in Normal and Sepsis Rats In Vivo and In Vitro
SO JOURNAL OF CHROMATOGRAPHIC SCIENCE
LA English
DT Article
DE Jinhongtang granule; pharmacokinetics; LC-MS; MS; sepsis
ID FLAVONOIDS
AB Jinhongtang granule (JHT) is a traditional Chinese medicine formula used for treatment of infection diseases including severe COVID-19. However, pharmacokinetics of JHT was unknown, especially in infection condition. A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed to simultaneously quantify ten active components form JHT in rat plasma. MS detection was performed by MRM scanning operating in the negative ionization mode. The method showed good linearity (r > 0.997). The accuracy, precision, matrix effect, recovery and stability were all satisfactory with current criterion. The method was successfully applied to compare the pharmacokinetic difference between normal and sepsis rats. The pharmacokinetic behaviors of analytes in sepsis rats were significantly different from those in normal rats. C-max and AUC of rhein, emodin, aloe emodin, rhein-8-glucoside, aloe emodin 8-glucoside, protocatechuic acid, epicatechin and salidroside, were significantly increased in sepsis rats, except for 4-hydroxycinnamic acid and ferulic acid. In vitro intestinal absorption study using everted intestinal sac preparations indicated that the intestinal permeability was altered under sepsis. In conclusion, pharmacokinetic difference of JHT between normal and sepsis rats were evaluated for the first time, which provided useful information for the clinical application of JHT as an integrative therapy for severe and critical COVID-19.
C1 [Wu, Fan; Zhang, Yu; Zhao, Ting; Tian, Xiangge; Huo, Xiaokui; Ma, Xiaochi] Dalian Med Univ, Affiliated Hosp 2, Pharmaceut Res Ctr, 467 Zhongshan Rd, Dalian 116023, Peoples R China.
   [Wu, Fan; Zhang, Baojing; Wang, Yan; Sun, Chengpeng] Dalian Med Univ, Coll Pharm, Inst Integrat Med, Dalian 116044, Peoples R China.
   [Fang, Bangjiang] Shanghai Univ Tradit Chinese Med, LongHua Hosp, Dept Emergency, Shanghai 200032, Peoples R China.
C3 Dalian Medical University; Dalian Medical University; Shanghai
   University of Traditional Chinese Medicine
RP Huo, XK; Ma, XC (corresponding author), Dalian Med Univ, Affiliated Hosp 2, Pharmaceut Res Ctr, 467 Zhongshan Rd, Dalian 116023, Peoples R China.
EM maxc1978@163.com; huoxiaokui@163.com
RI Huo, Xiaokui/AAD-6875-2019
OI Huo, Xiaokui/0000-0003-4056-7987
FU National Key Research and Development Program of China [2018YFC1705900];
   National Natural Science Foundation of China [81903706]; Distinguished
   professor of Liaoning Province [XLYC2002008]; Science Foundation of
   Department of Education of Liaoning Province [LZ2020054]
FX The National Key Research and Development Program of China
   (2018YFC1705900), National Natural Science Foundation of China (No.
   81903706), Distinguished professor of Liaoning Province (XLYC2002008),
   Science Foundation of Department of Education of Liaoning Province
   (LZ2020054).
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NR 40
TC 4
Z9 4
U1 2
U2 50
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0021-9665
EI 1945-239X
J9 J CHROMATOGR SCI
JI J. Chromatogr. Sci.
PD MAY 30
PY 2023
VL 61
IS 5
BP 440
EP 452
DI 10.1093/chromsci/bmac043
EA AUG 2022
PG 13
WC Biochemical Research Methods; Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA I1GA0
UT WOS:000834284200001
PM 35913259
DA 2026-05-27
ER

PT J
AU Maistro, EL
   Terrazzas, PM
   Perazzo, FF
   Gaivao, IOD
   Sawaya, ACHF
   Rosa, PCP
AF Maistro, Edson Luis
   Terrazzas, Peterson Menezes
   Perazzo, Fabio Ferreira
   Gaivao, Isabel O'Neill De Mascarenhas
   Sawaya, Alexandra Christinie Helena Frankland
   Rosa, Paulo Cesar Pires
TI Salix alba (white willow) medicinal plant presents genotoxic
   effects in human cultured leukocytes
SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
LA English
DT Article
DE White willow genotoxicity; Salix alba bark extract genotoxicity; Salix
   comet assay; Salicaceae toxicity; Salix micronucleus test
ID IN-VITRO; AQUEOUS EXTRACT; BARK EXTRACTS; INHIBITION; TOXICOLOGY;
   SAFETY; CELLS; L.
AB Salix alba (SA), commonly known as white willow, is a plant used in folk medicine for the treatment of chronic and acute inflammation, infection, pain, and fever. The phytochemical characterization of the bark extract of this plant indicated that its main component is salicin, a precursor of the anti-inflammatory agent acetylsalicylic acid. Considering the lack of studies evaluating the genetic toxicity and cytotoxic action of SA bark extract on human cells, as well as the chemical characterization of its major phenolic compounds, the present study was designed to (1) investigate the cytotoxic and genotoxic potential of SA bark extract on human peripheral leukocyte cells and human hepatoma cell line HepG2, and (2) characterize its major phenolic constituents. The phenolic compounds found were salicylic acid, salicin, salidroside, saligenin, tremulodin, salicoylsalicin, salicortin, and tremulacin. The results using trypan blue staining test showed viability decreases (viability less than 70%) for concentrations of SA extract equal and higher to 200 mu g/ml. Low genotoxic activity (comet assay) was exhibited for 50 and 100 mu g/ml SA extract in human leukocytes. SA did not exert a marked clastogenic/aneugenic effect on leukocytes and HepG2 human cells. Data suggest that the genotoxic effects of SA bark extract occur when it is not metabolized by liver enzymes.
C1 [Maistro, Edson Luis] Sao Paulo State Univ UNESP, Speech & Hearing Therapy Dept, Sao Paulo, Brazil.
   [Maistro, Edson Luis; Terrazzas, Peterson Menezes] Sao Paulo State Univ UNESP, Inst Biociencias, Programa Posgrad Biol Geral & Aplicada, Sao Paulo, Brazil.
   [Perazzo, Fabio Ferreira] Univ Fed Sao Paulo, Inst Environm Chem & Pharmaceut Sci, Sao Paulo, Brazil.
   [Gaivao, Isabel O'Neill De Mascarenhas] Univ Tras Os Montes & Alto Douro UTAD, Dept Genet & Biotechnol, Vila Real, Portugal.
   [Gaivao, Isabel O'Neill De Mascarenhas] Univ Tras Os Montes & Alto Douro UTAD, Anim & Vet Res Ctr CECAV, Vila Real, Portugal.
   [Sawaya, Alexandra Christinie Helena Frankland; Rosa, Paulo Cesar Pires] Univ Estadual Campinas, Fac Pharmaceut Sci, Sao Paulo, Brazil.
C3 Universidade Estadual Paulista; Universidade de Sao Paulo; Universidade
   Estadual Paulista; Universidade Federal de Sao Paulo (UNIFESP);
   University of Tras-os-Montes & Alto Douro; University of Tras-os-Montes
   & Alto Douro; Universidade Estadual de Campinas
RP Maistro, EL (corresponding author), Sao Paulo State Univ UNESP, Speech & Hearing Therapy Dept, Ave Hygino Muzzi Filho 737,Caixa Postal 18, BR-17525900 Marilia, SP, Brazil.
EM edson.maistro@unesp.br
RI Sawaya, Alexandra/F-3999-2012; Maistro, Edson Luis/AAQ-7262-2020;
   Gaivao, Isabel/K-4240-2013; /G-2233-2012
OI Maistro, Edson Luis/0000-0003-0757-7876; Gaivao,
   Isabel/0000-0003-4461-7021; 
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
   [2014/26882-2]
FX This study was financially supported by Fundacao de Amparo a Pesquisa do
   Estado de Sao Paulo (FAPESP) [Grant: 2014/26882-2].
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NR 43
TC 35
Z9 39
U1 1
U2 27
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1528-7394
EI 1087-2620
J9 J TOXICOL ENV HEAL A
JI J. Toxicol. Env. Health Part A
PD DEC 17
PY 2019
VL 82
IS 23-24
BP 1223
EP 1234
DI 10.1080/15287394.2019.1711476
EA JAN 2020
PG 12
WC Environmental Sciences; Public, Environmental & Occupational Health;
   Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health; Toxicology
GA KG0ZP
UT WOS:000505854400001
PM 31906808
OA Green Submitted
DA 2026-05-27
ER

PT J
AU Lewicki, S
   Skopinska-Rozewska, E
   Balan, BJ
   Kalicki, B
   Patera, J
   Wilczak, J
   Wasiutynski, A
   Zdanowski, R
AF Lewicki, Slawomir
   Skopinska-Rozewska, Ewa
   Balan, Barbara Joanna
   Kalicki, Boleslaw
   Patera, Janusz
   Wilczak, Jacek
   Wasiutynski, Aleksander
   Zdanowski, Robert
TI Morphofunctional Renal Alterations in Progeny of Mice Fed Rhodiola
   kirilowii Extracts or Epigallocatechin During Pregnancy and
   Lactation
SO JOURNAL OF MEDICINAL FOOD
LA English
DT Article
DE medicinal food; medicinal plants; mice; renal impairments
ID TUMOR-INDUCED ANGIOGENESIS; ACUTE KIDNEY INJURY; METABOLIC-ACTIVITY;
   ROSEA EXTRACTS; GRANULOCYTES; SALIDROSIDE; MOLECULE; CHILDREN
AB Treating infections in pregnant patients is potentially dangerous even when herbal medicines are used. Many herbal medicines, among them extracts from plants of Rhodiola genus, have antimicrobial, anti-inflammatory, and immunostimulatory properties owing to their polyphenol content; they may, however, affect fetal development due to their antiangiogenic properties. The aim of this study was to explain whether daily feeding pregnant and lactating mice with 20 mg/kg Rhodiola kirilowii aqueous (RKW) or 50% hydro-alcoholic (RKW-A) extracts, or 0.2 mg/kg epigallocatechin (EGC, antiangiogenic compound of Rhodiola extracts), may lead to abnormalities in morphology and function of the kidneys of adult progeny. Such abnormalities were not observed in the kidneys of 6-week-old offspring, neither in RKW nor in the control group. However, the progeny of RKW-A- or EGC-fed mothers presented morphometric abnormalities in the kidney structure, with a significantly higher number of glomeruli/mm(2) and a lower diameter of glomeruli (RKW-A group) or a significantly higher glomeruli diameter (EGC), than in the control and RKW groups. Abnormalities in serum vascular endothelial growth factor, tumor necrosis factor (TNF)-alpha, urea, creatinine, and cystatin C levels were also found. We recommend caution in long-term use of RKW-A extract and EGC-rich foods during pregnancy and lactation.
C1 [Lewicki, Slawomir; Zdanowski, Robert] Mil Inst Hyg & Epidemiol, Dept Regenerat Med, PL-01163 Warsaw, Poland.
   [Skopinska-Rozewska, Ewa] Mil Inst Hyg & Epidemiol, Dept Microwave Safety, Warsaw, Poland.
   [Skopinska-Rozewska, Ewa] Med Univ Warsaw, Ctr Biostruct Res, Pathomorphol Dept, Warsaw, Poland.
   [Balan, Barbara Joanna] Med Univ Warsaw, Dept Immunol Biochem & Nutr, Warsaw, Poland.
   [Kalicki, Boleslaw] Mil Inst Med, Dept Pediat Nephrol & Allergol, Warsaw, Poland.
   [Patera, Janusz] Mil Inst Med, Dept Pathol, Warsaw, Poland.
   [Wilczak, Jacek] Warsaw Univ Life Sci, Fac Vet Med, Dept Physiol Sci, Warsaw, Poland.
   [Wasiutynski, Aleksander] Natl Inst Geriatr Rheumatol & Rehabil, Pathomorphol Dept, Warsaw, Poland.
C3 Military Institute of Hygiene & Epidemiology (MIHE); Military Institute
   of Hygiene & Epidemiology (MIHE); Medical University of Warsaw; Medical
   University of Warsaw; Military Institute of Aviation Medicine; Military
   Institute of Aviation Medicine; Warsaw University of Life Sciences;
   National Institute of Geriatrics, Rheumatology & Rehabilitation
RP Lewicki, S (corresponding author), Mil Inst Hyg & Epidemiol, Dept Regenerat Med, PL-01163 Warsaw, Poland.
EM lewickis@gmail.com
RI ; Lewicki, Sławomir/AAZ-4709-2020
OI Zdanowski, Robert/0000-0003-0455-1072; Lewicki,
   Sławomir/0000-0002-0539-0680; Bałan, Barbara Joanna/0000-0001-6704-0806;
   Kalicki, Bolesław/0000-0003-1606-5100; Wilczak,
   Jacek/0000-0002-3053-3663
FU National Centre of Science [2012/05/B/NZ7/03219]
FX The study was supported by the National Centre of Science, grant number:
   2012/05/B/NZ7/03219.
CR [Anonymous], HERBA POL
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NR 35
TC 9
Z9 9
U1 0
U2 21
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-620X
EI 1557-7600
J9 J MED FOOD
JI J. Med. Food
PD JAN
PY 2017
VL 20
IS 1
BP 86
EP 92
DI 10.1089/jmf.2016.0126
PG 7
WC Chemistry, Medicinal; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology; Nutrition &
   Dietetics
GA EH9UO
UT WOS:000392117100011
PM 27935764
DA 2026-05-27
ER

PT J
AU Lu, Y
   Deng, B
   Xu, LH
   Liu, HJ
   Song, YZ
   Lin, FX
AF Lu, Yao
   Deng, Bin
   Xu, Luhua
   Liu, Hanjiao
   Song, Yinzhi
   Lin, Fengxia
TI Effects of Rhodiola Rosea Supplementation on Exercise and Sport: A
   Systematic Review
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE Rhodiola rosea; exercise; nutritional supplements; performance; A
   systematic review
ID OXIDATIVE STRESS; INFLAMMATION; PERFORMANCE; SALIDROSIDE
AB Rhodiola rosea (Golden Root Extract; RR) is an herbaceous perennial, which is native to high altitude areas, such as East Asia, Central Asia, Siberia, and North America. It has been studied for its positive pharmacological effects on health. However, only a handful of studies have evaluated the effects of RR as an exercise supplement for sport and physical activity. The aim of this study was to evaluate whether Rhodiola can be used as a supplement to improve human exercise ability. Studies were reviewed in accordance with the PRISMA guidelines and conducted between August and November, 2021. Databases searched included Cochrane, Embase, Web of Science, PubMed and East View Universal Database. Related terms were combined with keywords and MeSH subject headings using the corresponding Boolean operators: Rhodiola rosea, arctic root, roseroot, golden root, hongjingtian, and sports and exercise. A total of 10 papers were reviewed. Most of the studies reported that RR supplementation has a positive effect on athletic ability and sports performance, and no obvious adverse reactions were reported. Subjects taking RR showed a reduction in pain and muscle damage after exercise training, improved skeletal muscle damage, enhanced antioxidant capacity thereby reducing oxidative stress, reduced RPE scores, and improved athletic explosive power, but did not reduce the rating of perceived exertion (RPE) scores. RR appears to act as a safe and effective supplementation for sport and exercise.
C1 [Lu, Yao] Fujian Univ Tradit Chinese Med, Sch Nursing, Fuzhou, Peoples R China.
   [Deng, Bin; Xu, Luhua; Song, Yinzhi; Lin, Fengxia] Guangzhou Univ Chinese Med, Shenzhen Baoan Dist Tradit Chinese Med Hosp, Dept Cardiol, Affiliated Hosp, Shenzhen, Peoples R China.
   [Liu, Hanjiao] Guangzhou Univ Chinese Med, Shenzhen Baoan Dist Tradit Chinese Med Hosp, Dept Nursing, Affiliated Hosp, Shenzhen, Peoples R China.
C3 Fujian University of Traditional Chinese Medicine; Guangzhou University
   of Chinese Medicine; Guangzhou University of Chinese Medicine
RP Lin, FX (corresponding author), Guangzhou Univ Chinese Med, Shenzhen Baoan Dist Tradit Chinese Med Hosp, Dept Cardiol, Affiliated Hosp, Shenzhen, Peoples R China.
EM szlinfx@163.com
RI Fengxia, Lin/GLV-5962-2022
FU National Natural Science Foundation of China [82004320]; Science and
   Technology Project of Shenzhen City of China [JCYJ20190807115201653]
FX & nbsp;This study was supported by the National Natural Science
   Foundation of China (82004320) and the Science and Technology Project of
   Shenzhen City of China (JCYJ20190807115201653).
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NR 32
TC 28
Z9 32
U1 1
U2 39
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD APR 7
PY 2022
VL 9
AR 856287
DI 10.3389/fnut.2022.856287
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 1C0KH
UT WOS:000792817200001
PM 35464040
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Liu, HX
   Guo, YB
   Zhu, RY
   Wang, LL
   Chen, BB
   Tian, YM
   Li, R
   Ma, RF
   Jia, QQ
   Zhang, H
   Xia, BK
   Li, Y
   Wang, XX
   Zhu, XF
   Zhang, RH
   Bromme, D
   Gao, SH
   Zhang, DW
   Pei, XH
AF Liu, Haixia
   Guo, Yubo
   Zhu, Ruyuan
   Wang, Lili
   Chen, Beibei
   Tian, Yimiao
   Li, Rui
   Ma, Rufeng
   Jia, Qiangqiang
   Zhang, Hao
   Xia, Bingke
   Li, Yu
   Wang, Xinxiang
   Zhu, Xiaofeng
   Zhang, Ronghua
   Bromme, Dieter
   Gao, Sihua
   Zhang, Dongwei
   Pei, Xiaohua
TI Fructus Ligustri Lucidi preserves bone quality through induction
   of canonical Wnt/β-catenin signaling pathway in ovariectomized rats
SO PHYTOTHERAPY RESEARCH
LA English
DT Article
DE bone quality; Fructus Ligustri Lucidi; medicated serum; ovariectomized
   rats; primary osteoblasts; Wnt/beta-catenin
ID OSTEOBLAST DIFFERENTIATION; IGF-1; MICROARCHITECTURE; OSTEOPOROSIS;
   INGREDIENTS; METABOLISM; WNT
AB Fructus Ligustri Lucidi(FLL) has been preclinically and clinically used to treat musculoskeletal diseases. However, whether and how FLL affect the canonical Wnt/beta-catenin signaling in the management of osteoporosis remains largely unknown. To this end, ovariectomized (OVX) rats and primary osteoblasts were administrated with FLL aqueous extract and medicated serum, respectively. Supplement of FLL to OVX rats maintains bone quality by attenuating the reduction in bone mineral density, strength and microstructure. The maintenance may be associated with upregulating the expression of insulin-like growth factor-1, osteoprotegerin, phospho (p)-low-density lipoprotein receptor-related protein 6, p-glycogen synthase kinase 3 beta (GSK3 beta), beta-catenin, Runx2 and c-Myc, and downregulating the expressions of sclerostin (SOST), dickkopf-related protein 1 (DKK1), GSK3 beta and p-beta-catenin in rat femurs and tibias. In addition, the medicated serum promotes osteoblastic bone formation through activation of Wnt/beta-catenin signaling via inhibition of DKK1 and SOST overexpression. Salidroside may be one of the active ingredients in FLL that are beneficial for bone homeostasis. In summary, our results suggest that FLL may preserve bone quality through induction of canonical Wnt/beta-catenin signaling via inhibition of DKK1 and SOST overexpression. And FLL may offer a new source of the DKK1 or SOST inhibitors in protection against osteoporosis.
C1 [Liu, Haixia; Guo, Yubo; Zhu, Ruyuan; Wang, Lili; Chen, Beibei; Tian, Yimiao; Li, Rui; Ma, Rufeng; Jia, Qiangqiang; Zhang, Hao; Xia, Bingke; Gao, Sihua; Zhang, Dongwei] Beijing Univ Chinese Med, Tradit Chinese Med Sch, Diabet Res Ctr, Beijing, Peoples R China.
   [Li, Yu] Beijing Univ Chinese Med, Tradit Chinese Med Sch, Dept Histol & Embryol, Beijing, Peoples R China.
   [Li, Yu; Zhang, Dongwei] Beijing Univ Chinese Med, Tradit Chinese Med Sch, Sino Canada Antifibrosis Ctr, Beijing, Peoples R China.
   [Wang, Xinxiang] Beijing Univ Chinese Med, Affiliated Hosp 2, Ctr Expt Med, Beijing, Peoples R China.
   [Zhu, Xiaofeng; Zhang, Ronghua] Jinan Univ, Affiliated Hosp 1, Dept Chinese Med, Jinan, Peoples R China.
   [Bromme, Dieter] Univ British Columbia, Fac Dent, Vancouver, BC, Canada.
   [Pei, Xiaohua] Beijing Univ Chinese Med, Fangshan Hosp BUCM, Beijing 100029, Peoples R China.
C3 Beijing University of Chinese Medicine; Beijing University of Chinese
   Medicine; Beijing University of Chinese Medicine; Beijing University of
   Chinese Medicine; University of Jinan; University of British Columbia;
   Beijing University of Chinese Medicine
RP Pei, XH (corresponding author), Beijing Univ Chinese Med, Fangshan Hosp BUCM, Beijing 100029, Peoples R China.; Zhang, DW (corresponding author), Beijing Univ Chinese Med, Diabet Res Ctr, Beijing 100029, Peoples R China.
EM dongwei1006@gmail.com; pxh_127@163.com
RI ; Zhu, Xiaofeng/F-3601-2016; Zhang, Dongwei/AAS-8384-2020;
   /AAS-6452-2021
OI Guo, Yu-bo/0000-0002-9724-1649; 
FU National Key Research and Development Plan [2018YFC2002500]; Program for
   Innovative Research Team in University [IRT_17R11]; Beijing Municipal
   Natural Science Foundation [7172126]; Canadian Institute of Health
   Research; National Natural Science Foundation of China [81874373,
   81673837]; Program for QiHuang Scholar (Sihua Gao) in State
   Administration of Traditional Chinese Medicine
FX National Key Research and Development Plan, Grant/Award Number:
   2018YFC2002500; Program for Innovative Research Team in University,
   Grant/Award Number: IRT_17R11; Beijing Municipal Natural Science
   Foundation, Grant/Award Number: 7172126; Canadian Institute of Health
   Research, Grant/Award Number: CIHR-MOP; National Natural Science
   Foundation of China, Grant/Award Number: 81874373; 81673837; Program for
   QiHuang Scholar (Sihua Gao) in State Administration of Traditional
   Chinese Medicine
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NR 51
TC 17
Z9 24
U1 0
U2 34
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD JAN
PY 2021
VL 35
IS 1
BP 424
EP 441
DI 10.1002/ptr.6817
EA AUG 2020
PG 18
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA PZ1DN
UT WOS:000555413200001
PM 32755017
DA 2026-05-27
ER

PT J
AU Lv, CX
   Li, Q
   Zhang, XW
   He, BS
   Xu, HR
   Yin, YD
   Liu, R
   Liu, JJ
   Chen, XH
   Bi, KS
AF Lv, Chunxiao
   Li, Qing
   Zhang, Xiaowen
   He, Bosai
   Xu, Huarong
   Yin, Yidi
   Liu, Ran
   Liu, Jingjing
   Chen, Xiaohui
   Bi, Kaishun
TI Simultaneous quantitation of polygalaxanthone III and four ginsenosides
   by ultra-fast liquid chromatography with tandem mass spectrometry in rat
   and beagle dog plasma after oral administration of Kai-Xin-San:
   Application to a comparative pharmacokinetic study
SO JOURNAL OF SEPARATION SCIENCE
LA English
DT Article
DE Alzheimer's disease; Ginsenosides; Kai-Xin-San; Pharmacokinetics;
   Polygalaxanthone III
ID RADIX POLYGALAE; PERFORMANCE; GINSENG; RE; RD
AB A fast, selective, and quantitative ultra-fast liquid chromatography with tandem mass spectrometry method has been developed and validated for the simultaneous quantitation of polygalaxanthone III, ginsenoside Rb1, ginsenoside Rd, ginsenoside Re, and ginsenoside Rg1 in the plasma of rat and beagle dog after oral administration of Kai-Xin-San. After addition of the internal standard, salidroside, the plasma samples were extracted by liquid-liquid extraction and separated on a Venusil MP C-18 column with methanol/0.01% acetic acid water as mobile phase. The tandem mass spectrometric detection was performed in the multiple reaction monitoring with turbo ion spray source in a switching ionization mode. The method was examined, and found to be precise and accurate with the linearity range of the compounds. The intra- and interday precision and accuracy of the analytes were well within acceptance criteria (+/- 15%). The mean extraction recoveries of analytes and internal standard were all >75.0%. The validated method has been successfully applied to comparing pharmacokinetic profiles of analytes in rat and beagle dog plasma. The results indicated that no significant differences were observed in pharmacokinetic parameters of ginsenoside Rg1, while the others had significant differences, which may due to the different mechanisms of absorption and metabolism.
C1 [Lv, Chunxiao; Li, Qing; He, Bosai; Xu, Huarong; Liu, Ran; Liu, Jingjing; Chen, Xiaohui; Bi, Kaishun] Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China.
   [Zhang, Xiaowen; Yin, Yidi] Shenyang Pharmaceut Univ, Sch Chinese Mat Med, Shenyang 110016, Peoples R China.
   [Lv, Chunxiao; Li, Qing; Zhang, Xiaowen; He, Bosai; Xu, Huarong; Yin, Yidi; Liu, Ran; Liu, Jingjing; Chen, Xiaohui; Bi, Kaishun] Shenyang Pharmaceut Univ, Natl & Local United Engn Lab Key Technol Chinese, Shenyang 110016, Peoples R China.
C3 Shenyang Pharmaceutical University; Shenyang Pharmaceutical University;
   Shenyang Pharmaceutical University
RP Bi, KS (corresponding author), Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China.
EM kaishunbi.syphu@gmail.com
RI He, Bosai/OML-7628-2025; Li, Qing/AAD-3286-2022
OI Li, Qing/0000-0003-3087-4692
FU Liaoning Innovative Research Team in University [LT2013022]; National
   Development and Reform Commission for State Local Joint Engineering
   Laboratory
FX This study was supported by the Liaoning Innovative Research Team in
   University (no. LT2013022). This study was also supported by the
   National Development and Reform Commission for State Local Joint
   Engineering Laboratory.
CR Anand R, 2014, NEUROPHARMACOLOGY, V76, P27, DOI 10.1016/j.neuropharm.2013.07.004
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NR 23
TC 17
Z9 18
U1 0
U2 60
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 1615-9306
EI 1615-9314
J9 J SEP SCI
JI J. Sep. Sci.
PD MAY
PY 2014
VL 37
IS 9-10
BP 1103
EP 1110
DI 10.1002/jssc.201400058
PG 8
WC Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA AG1SN
UT WOS:000335196500008
PM 24610822
DA 2026-05-27
ER

PT J
AU Karkeszová, K
   Antosová, M
   Mastihuba, V
   Polakovic, M
AF Karkeszova, Klaudia
   Antosova, Monika
   Mastihuba, Vladimir
   Polakovic, Milan
TI Yeast β-fructosidase-catalyzed synthesis of tyrosol fructoside in
   mono- and biphasic organic-aqueous systems
SO CHEMICAL PAPERS
LA English
DT Article
DE Tyrosol; Transfructosylation; <italic>Saccharomyces cerevisiae
   beta</italic>-fructosidase; Organic-aqueous reaction systems
ID ENZYMATIC-SYNTHESIS; TRANSGLYCOSYLATION ACTIVITY; GALACTOSIDASE;
   SOLVENTS; WATER; OLIGOSACCHARIDES; SALIDROSIDE; EFFICIENT
AB Tyrosol and its glycosides offer cell protection from oxidative stress and various health benefits. In this study, Saccharomyces cerevisiae beta-fructosidase potential for synthesizing tyrosol fructoside in mono- and biphasic solvent systems was assessed using 1.5 M sucrose, 10 g/L or 25 g/L tyrosol, at pH 6 and 40 degrees C. Monophasic organic-water systems were designed with nine organic solvents (log P ranging from -1.35 to 0.5). Initial rates of sucrose hydrolysis, tyrosol and sucrose transfructosylation and tyrosol fructoside yields were evaluated. The hydrolytic activity increased with the addition of 5-15% organic solvents, revealing no clear correlation between the log P and sucrose hydrolysis rate. Simultaneously, transfructosylation reaction rates decreased, despite lower water activity. Notably, the effect of log P on tyrosol transfructosylation was observed in 70:30 (v/v) aqueous/organic biphasic systems. Differences in tyrosol fructoside synthesis in six biphasic reaction media were attributed to the unequal solubility of tyrosol in the organic phase, impacting its availability for the enzyme. Product yields were either similar to or lower than those in aqueous media, with no tyrosol fructoside partitioning into the organic phase, thus no effect of product stripping could be observed. Consequently, transfructosylation of tyrosol proves most effective in organic solvent-free media.
C1 [Karkeszova, Klaudia; Antosova, Monika; Polakovic, Milan] Slovak Univ Technol Bratislava, Inst Chem & Environm Engn, Fac Chem & Food Technol, Dept Chem & Biochem Engn, Radlinskeho 9, Bratislava 81237, Slovakia.
   [Mastihuba, Vladimir] Slovak Acad Sci, Inst Chem, Dubravska Cesta 9, Bratislava 84538, Slovakia.
   [Karkeszova, Klaudia] Ctr Vyskumu Vyvoja Sro, Envien Grp, Leopoldov 92041, Slovakia.
C3 Slovak University of Technology Bratislava; Slovak Academy of Sciences;
   Institute of Chemistry, SAS
RP Polakovic, M (corresponding author), Slovak Univ Technol Bratislava, Inst Chem & Environm Engn, Fac Chem & Food Technol, Dept Chem & Biochem Engn, Radlinskeho 9, Bratislava 81237, Slovakia.
EM milan.polakovic@stuba.sk
RI Antosova, Monika/HFZ-9237-2022; Polakovic, Milan/A-1080-2015; Mastihuba,
   Vladimír/S-7938-2017
OI Antosova, Monika/0000-0003-3671-9108; Polakovic,
   Milan/0000-0003-0238-8996; 
FU Agentra na Podporu Vskumu a Vvoja [APVV-18-0188]; Slovak Research and
   Development Agency; Slovak Grant Agency for Science [1/0515/22]; VEGA
FX This work was supported by grants from the Slovak Research and
   Development Agency (Grant No. APVV-18-0188) and the Slovak Grant Agency
   for Science (Grant No. VEGA 1/0515/22).
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NR 35
TC 1
Z9 1
U1 1
U2 4
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 0366-6352
EI 2585-7290
J9 CHEM PAP
JI Chem. Pap.
PD JAN
PY 2025
VL 79
IS 1
BP 85
EP 94
DI 10.1007/s11696-024-03798-4
EA NOV 2024
PG 10
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA U3C7K
UT WOS:001352558600001
OA hybrid
DA 2026-05-27
ER

PT J
AU Yuan, YC
   Bai, XL
   Liu, YM
   Tang, XY
   Yuan, H
   Liao, X
AF Yuan, Yun-Cong
   Bai, Xiao-Lin
   Liu, Yi-Ming
   Tang, Xiao-Yue
   Yuan, Hao
   Liao, Xun
TI Ligand fishing based on cell surface display of enzymes for inhibitor
   screening
SO ANALYTICA CHIMICA ACTA
LA English
DT Article
DE Ligand fishing; Surface display; Protein tyrosine phosphatase 1B;
   Inhibitor screening; Rhodiola rosea
ID ICE-NUCLEATION PROTEIN; PHOSPHATASE 1B INHIBITORS; MASS-SPECTROMETRY;
   ESCHERICHIA-COLI; SALIDROSIDE; IDENTIFICATION; RHODIOLA; TARGET; PTP1B;
   ROSEA
AB Ligand fishing for screening of enzyme inhibitors from complex chemical systems using baits prepared by cell surface display of the enzyme is herein demonstrated for the first time. Tyrosine phosphatase 1B (PTP1B), used as a model enzyme in this work, is displayed on the surface of E. coli cells by using ice nucleation protein (INP) as the anchoring motif. Infusion of PTP1B is characterized by western blot, immunofluorescence, proteinase K accessibility, and enzyme activity assays. Surface displayed PTP1B exhibits a maximum of 5.62 +/- 0.251 U/OD600 enzymatic activity and a better stability compared with free enzyme. PTP1B displayed cells are used as solid-phase extraction adsorbent in combination with HPLCMS to screen the inhibitors from the extracts of Rhodiola rosea, a traditional Chinese medicinal plant. Among many well-known active ingredients only arbutin is fished out with an IC50 value of 20.5 +/- 0.873 mu M, showing the inhibitor screening is highly selective. Furthermore, the equilibrium dissociation constant (K-D) of the complex of arbutin and PTP1B was determined to be 79.6 mu M by localized surface plasma resonance (LSPR) assay. The proposed ligand fishing technique using recombinant cells as baits opens a new avenue for screening of active compounds from natural products with accuracy and specificity. (C) 2021 Elsevier B.V. All rights reserved.
C1 [Yuan, Yun-Cong; Bai, Xiao-Lin; Tang, Xiao-Yue; Yuan, Hao; Liao, Xun] Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China.
   [Liu, Yi-Ming] Jackson State Univ, Dept Chem & Biochem, Jackson, MS 39217 USA.
   [Yuan, Yun-Cong; Tang, Xiao-Yue; Yuan, Hao] Univ Chinese Acad Sci, Beijing 100049, Peoples R China.
C3 Chinese Academy of Sciences; Chengdu Institute of Biology, CAS; Jackson
   State University; Chinese Academy of Sciences; University of Chinese
   Academy of Sciences, CAS
RP Liao, X (corresponding author), Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China.; Liu, YM (corresponding author), Jackson State Univ, Dept Chem & Biochem, Jackson, MS 39217 USA.
EM yiming.liu@jsums.edu; liaoxun@cib.ac.cn
RI Liao, Xun/V-7906-2019
FU Science and Technology Department of Sichuan Province of China
   [2017JY0062, 2016JZ0026]; US National Institutes of Health
   [1U554MD015929-01]; Chinese Academy of Sciences [KFJ-BRP-030]
FX This work was supported by the Science and Technology Department of
   Sichuan Province of China (2017JY0062 and 2016JZ0026 to XL); US National
   Institutes of Health (partially 1U554MD015929-01 to YML); and the
   Chinese Academy of Sciences (KFJ-BRP-030 to XL).
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NR 49
TC 17
Z9 17
U1 8
U2 116
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0003-2670
EI 1873-4324
J9 ANAL CHIM ACTA
JI Anal. Chim. Acta
PD APR 29
PY 2021
VL 1156
AR 338359
DI 10.1016/j.aca.2021.338359
EA MAR 2021
PG 8
WC Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA QW1XS
UT WOS:000628450900001
PM 33781459
DA 2026-05-27
ER

PT J
AU Nikolaichuk, H
   Typek, R
   Gnat, S
   Studzinski, M
   Choma, IM
AF Nikolaichuk, Hanna
   Typek, Rafal
   Gnat, Sebastian
   Studzinski, Marek
   Choma, Irena Maria
TI Effect-directed analysis as a method for quality and authenticity
   estimation of Rhodiola rosea L. preparations
SO JOURNAL OF CHROMATOGRAPHY A
LA English
DT Article
DE Authenticity; Effect-directed analysis; Rhodiola rosea L.; Rosavins;
   Salidroside; p-Tyrosol
AB Adulterations of food and pharmaceutical preparations are the important global problem. On the one hand, fraud practices are becoming more and more sophisticated while on the other, monitoring and uncovering falsifications are insufficient. One of the most common consumer concern is the quality and authenticity of the purchased products, related to the confidence that they have composition and properties in accordance with the manufacturer's declaration on the label. This refers also to pharmaceuticals potentially delivering great health benefits such as Rhodiola rosea L. supplements. The aim of this study was defining authenticity and possible adulterations of two R. rosea preparations basing on their TLCbioprofiles and the presence of biomarker compounds characteristic for this plant. The effect-directed analysis (EDA), i.e. TLC hyphenated with micro-chemical and biological assays performed directly on TLC plates followed by HPLC-ESI-MS was used for the bioprofiling of antioxidants, antibacterials, and inhibitors of lipase, acetylcholine, alpha-glucosidase and tyrosinase as well as for the identification of the biomarkers. The results pointed to the possible adulteration of one of the tested products related to the absence of two rosavins, the most important quality markers of R. rosea. (c) 2021 Maria Curie-Sklodowska University. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
C1 [Nikolaichuk, Hanna; Typek, Rafal; Choma, Irena Maria] Marie Curie Sklodowska Univ, Fac Chem, Inst Chem Sci, Dept Chromatog, Maria Curie Sklodowska Sq 3, PL-20031 Lublin, Poland.
   [Gnat, Sebastian] Univ Life Sci, Dept Vet Microbiol, Akad Str 13, PL-20950 Lublin, Poland.
   [Studzinski, Marek] Marie Curie Sklodowska Univ, Fac Chem, Inst Chem Sci, Dept Phys Chem, Maria Curie Sklodowska Sq 3, PL-20031 Lublin, Poland.
C3 Maria Curie-Sklodowska University; Maria Curie-Sklodowska University
RP Choma, IM (corresponding author), Marie Curie Sklodowska Univ, Fac Chem, Inst Chem Sci, Dept Chromatog, Maria Curie Sklodowska Sq 3, PL-20031 Lublin, Poland.
EM irena.choma@poczta.umcs.lublin.pl
RI Choma, Irena/AAG-9790-2021; Studziński, Marek/D-4824-2011; Gnat,
   Sebastian/J-4340-2019
OI Choma, Irena/0000-0002-6878-3748; Studziński, Marek/0000-0001-8226-1922;
   Nikolaichuk, Hanna/0000-0001-6292-483X; Gnat,
   Sebastian/0000-0001-9872-0046
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NR 24
TC 11
Z9 12
U1 0
U2 34
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0021-9673
EI 1873-3778
J9 J CHROMATOGR A
JI J. Chromatogr. A
PD JUL 19
PY 2021
VL 1649
AR 462217
DI 10.1016/j.chroma.2021.462217
EA MAY 2021
PG 8
WC Biochemical Research Methods; Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA SG8IB
UT WOS:000653682500005
PM 34034112
OA hybrid
DA 2026-05-27
ER

PT J
AU Huang, J
   Zheng, YX
   Wu, WX
   Xie, T
   Yao, H
   Pang, XB
   Sun, FZ
   Ouyang, L
   Wang, JH
AF Huang, Jian
   Zheng, Yaxin
   Wu, Wenxi
   Xie, Tao
   Yao, Hong
   Pang, Xiaobo
   Sun, Fuzhou
   Ouyang, Liang
   Wang, Jinhui
TI CEMTDD: The database for elucidating the relationships among herbs,
   compounds, targets and related diseases for Chinese ethnic minority
   traditional drugs
SO ONCOTARGET
LA English
DT Article
DE chinese ethnic minority traditional drug (CEMTD); xinjiang uygur
   autonomous region; database; herb; gerontology
ID SALVIANOLIC ACID-A; PROTEIN INTERACTIONS; MEDICINE; CELLS; WEB;
   SALIDROSIDE; ROBUSTNESS; VALIDATION; ACTIVATION; CYTOSCAPE
AB China has different ethnic minorities that establish their own medical systems and practice experience for thousand years, thereafter named Chinese Ethnic Minority Traditional Drugs (CEMTDs) (http://www.cemtdd.com/index.html). Since many compounds from CEMTDs have been reported to perturb human's dysfunction network and restore human normal physiological conditions, the relationships amongst a series of compounds from specific herbs, their targets and relevant diseases have become our main focus in CEMTD modernization. Herein, we have constructed the first Chinese Ethnic Minority Traditional Drug Database (CEMTDD) mainly from Xinjiang Uygur Autonomous Region (XUAR), retrieving CEMTD-related information from different resources. CEMTDD contains about 621 herbs, 4, 060 compounds, 2, 163 targets and 210 diseases, among which most of herbs can be applied into gerontology therapy including inflammation, cardiovascular disease and neurodegenerative disease. Gerontology is highly occurred in XUAR, and has abundant experience in treating such diseases, which may benefit for developing a new gerontology therapeutic strategy. CEMTDD displays networks for intricate relationships between CEMTDs and treated diseases, as well as the interrelations between active compounds and action targets, which may shed new light on the combination therapy of CEMTDs and further understanding of their herb molecular mechanisms for better modernized utilizations of CEMTDs, especially in gerontology.
C1 [Huang, Jian; Zheng, Yaxin; Wu, Wenxi; Yao, Hong; Pang, Xiaobo; Sun, Fuzhou; Wang, Jinhui] Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Sch Tradit Chinese Mat Med, Shenyang, Peoples R China.
   [Xie, Tao; Ouyang, Liang] Sichuan Univ, West China Hosp, Collaborat Innovat Ctr Biotherapy, State Key Lab Biotherapy, Chengdu 610064, Peoples R China.
   [Wang, Jinhui] Shihezi Univ, Sch Pharm, Shihezi, Peoples R China.
C3 Shenyang Pharmaceutical University; Sichuan University; Shihezi
   University
RP Wang, JH (corresponding author), Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Sch Tradit Chinese Mat Med, Shenyang, Peoples R China.
EM ouyangliang@scu.edu.cn; profwjh@126.com
RI Wang, Jinhui/AAS-7317-2021; Ouyang, Liang/A-2751-2010
OI Ouyang, Liang/0000-0001-5537-8834
FU National 973 Basic Research Program of China [2013CB911300]; National
   Science and Technology Pillar Program [2012BAI30B02]; Liaoning Science
   and Technology Project [2013226027-4]; National Natural Science
   Foundation of China [U1170302, U1303124, 81473091, 81260628, 81303270];
   Shenyang Pharmaceutical University Scientific Research Fund
   [ZCJJ2013407]
FX This work was supported in part by grants from the National 973 Basic
   Research Program of China (No. 2013CB911300), Key Projects of the
   National Science and Technology Pillar Program (No. 2012BAI30B02),
   Liaoning Science and Technology Project (No. 2013226027-4), and National
   Natural Science Foundation of China (No. U1170302, U1303124, 81473091,
   81260628 and 81303270), and Shenyang Pharmaceutical University
   Scientific Research Fund (No. ZCJJ2013407).
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NR 44
TC 13
Z9 18
U1 0
U2 34
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
EI 1949-2553
J9 ONCOTARGET
JI Oncotarget
PD JUL 10
PY 2015
VL 6
IS 19
BP 17675
EP 17684
DI 10.18632/oncotarget.3789
PG 10
WC Oncology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Cell Biology
GA CO2VB
UT WOS:000359013600085
PM 25970778
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Li, WL
   Ding, JX
   Bai, J
   Hu, Y
   Song, H
   Sun, XM
   Ji, YB
AF Li, Wen-Lan
   Ding, Jing-Xin
   Bai, Jing
   Hu, Yang
   Song, Hui
   Sun, Xiang-Ming
   Ji, Yu-Bin
TI Research on correlation of compositions with oestrogenic activity of
   Cistanche based on LC/Q-TOF-MS/MS technology
SO OPEN CHEMISTRY
LA English
DT Article
DE Cistanche deserticola; LC/Q-TOF-MS; Oestrogenic activity; principal
   component analysis (PCA); Uterus growth test
ID SPECTRUM-EFFECT RELATIONSHIPS; PHENYLETHANOID GLYCOSIDES;
   QUALITY-CONTROL; UPLC; PERFORMANCE; TUBULOSA; IDENTIFICATION;
   FINGERPRINTS; ECHINACOSIDE; COMPONENTS
AB LC technology is a recognized method used worldwide to evaluate the quality of traditional Chinese medicines (TCM). The quality of TCM has a direct impact on its efficacy. Therefore, in order to thoroughly reveal how TCM exerts its efficacy, first of all, it is necessary to understand the material basis for its efficacy, and then to control the quality of active compounds. The application of the spectrum-effect relationship method is crucial for determining the pharmacological material basis. The goal of this paper was to investigate the underlying correlations between the chemical profiles and oestrogenic activity of Cistanche, to reveal the active compounds. The chemical profiles of Cistanche were recorded using HPLC/QTOF-MS/MS, and oestrogenic activity was determined by the Uterus growth test and the MTT assay. Then combining the results of bivariate analysis, principal component analysis and gray correlation analysis method, fifteen active compounds were identified. They are 8-epiloganic acid, salidroside, syringalide A 3'-alpha-l-rhamnopyranoside, cistanoside A, echinacoside, cistanoside F, cistanoside B, cistanoside C, osmanthuside B, acteoside, isoacteoside, tubuloside B, 2'-acetylacteoside, and two unknown compounds. This study lays a foundation for in vivo studies of Cistanche, and for the development of its clinical application.
C1 [Li, Wen-Lan; Hu, Yang; Sun, Xiang-Ming] Harbin Univ Commerce, Sch Pharm, Harbin 150076, Heilongjiang, Peoples R China.
   [Ding, Jing-Xin; Bai, Jing; Song, Hui; Ji, Yu-Bin] Harbin Univ Commerce, Res Ctr Life Sci & Environm Sci, Harbin 150076, Heilongjiang, Peoples R China.
   [Ding, Jing-Xin; Bai, Jing; Song, Hui; Ji, Yu-Bin] Minist Educ, Engn Res Ctr Nat Anticanc Drugs, Harbin 150076, Heilongjiang, Peoples R China.
C3 Harbin University of Commerce; Harbin University of Commerce
RP Li, WL (corresponding author), Harbin Univ Commerce, Sch Pharm, Harbin 150076, Heilongjiang, Peoples R China.
EM liwenlan2010@163.com
FU National Natural Science Foundation of China [81073015]; Nature
   Scientific Foundation of Heilongjiang Province [ZD2017014]; Young
   innovative talent training plan of the College in the Heilongjiang
   Province [UNPYSCT-2017209]
FX This project was supported by the National Natural Science Foundation of
   China (No. 81073015), Nature Scientific Foundation of Heilongjiang
   Province (ZD2017014), and the Young innovative talent training plan of
   the College in the Heilongjiang Province (UNPYSCT-2017209). The authors
   declare that there is no conflict of interest regarding the publication
   of this paper.
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   Yan Y, 2017, J CHROMATOGR A, V1501, P39, DOI 10.1016/j.chroma.2017.04.034
   Yang B, 2017, MOLECULES, V22, DOI 10.3390/molecules22071237
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NR 30
TC 8
Z9 10
U1 1
U2 36
PU DE GRUYTER POLAND SP ZOO
PI WARSAW
PA BOGUMILA ZUGA 32A STR., 01-811 WARSAW, POLAND
SN 2391-5420
J9 OPEN CHEM
JI Open Chem.
PD JAN
PY 2019
VL 17
IS 1
BP 1
EP 12
DI 10.1515/chem-2019-0001
PG 12
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA HK5EG
UT WOS:000457987300001
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Yao, WF
   Dai, J
   Zheng, CZ
   Bao, BH
   Cheng, HB
   Zhang, L
   Ding, AW
   Li, W
AF Yao, Weifeng
   Dai, Jin
   Zheng, Chuanzhu
   Bao, Beihua
   Cheng, Haibo
   Zhang, Li
   Ding, Anwei
   Li, Wei
TI Quality assessment of Fructus Ligustri Lucidi by the simultaneous
   determination of six compounds and chemometric analysis
SO JOURNAL OF SEPARATION SCIENCE
LA English
DT Article
DE Chemometrics; Fructus Ligustri Lucidi; High-performance liquid
   chromatography; Quality assessment; Traditional Chinese medicine
ID PERFORMANCE LIQUID-CHROMATOGRAPHY; OLEANOLIC ACID; URSOLIC ACID; AIT;
   FRUITS; CELLS; APOPTOSIS; EXTRACT
AB A comprehensive strategy was designed for the quality assessment of Fructus Ligustri Lucidi, a well-known and commonly used herbal medicine in clinical practice in China. First, a simple and stable method of high-performance liquid chromatography was developed for the simultaneous quantitative analysis of six compounds, namely, salidroside, nuzhenide, specnuezhenide, oleanic acid, ursolic acid, and acetyl oleanic acid in Fructus Ligustri Lucidi. The separation of analytes was conducted on a C-18 column (200 mm x 4.6 mm, 5 mu m) at 30 degrees C, and the wavelength of UV detector was set at 210 nm. In quantitative analysis, all of the calibration curves showed good linear regression (R-2 > 0.9994) within the tested ranges, and the mean recoveries of three different concentrations ranged from 95.21-102.34%. The described method was applied to determine 11 batches of samples collected from different stores in China. Then multiple chemometrics analysis including hierarchical cluster analysis and principal component analysis were performed to classify samples and search significant compounds. Three notable compounds, specnuezhenide, oleanic acid, and acetyl oleanic acid, were discovered for better quality control compared with those stated in the China pharmacopeia. The results demonstrated that this strategy could be readily utilized for the comprehensive quality control of Fructus Ligustri Lucidi.
C1 [Yao, Weifeng; Zheng, Chuanzhu; Bao, Beihua; Zhang, Li; Ding, Anwei; Li, Wei] Nanjing Univ Chinese Med, Sch Pharm, Nanjing 210023, Jiangsu, Peoples R China.
   [Yao, Weifeng; Dai, Jin] Univ Washington, Dept Anesthesiol & Pain Med, Northwest Metabol Res Ctr, Seattle, WA 98195 USA.
   [Cheng, Haibo] Nanjing Univ Chinese Med, Jiangsu Engn Lab Res & Ind Empir Formulae, Nanjing 210023, Jiangsu, Peoples R China.
   [Bao, Beihua; Zhang, Li; Ding, Anwei] Nanjing Univ Chinese Med, Jiangsu Collaborat Innovat Ctr Chinese Med Resour, Nanjing 210023, Jiangsu, Peoples R China.
   [Bao, Beihua; Zhang, Li; Ding, Anwei] Nanjing Univ Chinese Med, Natl & Local Collaborat Engn Ctr Chinese Med Reso, Nanjing 210023, Jiangsu, Peoples R China.
C3 Nanjing University of Chinese Medicine; University of Washington;
   University of Washington Seattle; Nanjing University of Chinese
   Medicine; Nanjing University of Chinese Medicine; Nanjing University of
   Chinese Medicine
RP Yao, WF (corresponding author), Nanjing Univ Chinese Med, Coll Pharm, 003 Mail Box,138 Xianlin Rd, Nanjing 210023, Jiangsu, Peoples R China.
EM zhangliguanxiong@163.com; awding105@163.com; njweifengyao@163.com
RI Bao, Bei-hua/ITR-8947-2023; Yao, Weifeng/I-7394-2013
OI Bao, Bei-hua/0000-0002-6067-3093; zhang, li/0000-0001-7936-3864; Ding,
   Anwei/0000-0003-1839-6579
FU National Natural Science Foundation of China [81001599, 81173547,
   81373972]; Priority Academic Program Development of Jiangsu Higher
   Education Institutions (PAPD)
FX The authors are grateful for the financial support by National Natural
   Science Foundation of China (Grant No. 81001599, 81173547 and 81373972)
   and A Project Funded by the Priority Academic Program Development of
   Jiangsu Higher Education Institutions (PAPD).
CR Chen QF, 2013, PHYTOTHER RES, V27, P973, DOI 10.1002/ptr.4820
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NR 22
TC 19
Z9 23
U1 0
U2 63
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY
SN 1615-9306
EI 1615-9314
J9 J SEP SCI
JI J. Sep. Sci.
PD JUN
PY 2015
VL 38
IS 11
BP 1822
EP 1827
DI 10.1002/jssc.201500094
PG 6
WC Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA CJ9QC
UT WOS:000355836300002
PM 25781582
DA 2026-05-27
ER

PT J
AU Wang, ZG
   Hu, HL
   Chen, F
   Zou, L
   Yang, MF
   Wang, AQ
   Foulsham, JE
   Lan, K
AF Wang, Zhanguo
   Hu, Huiling
   Chen, Fang
   Zou, Liang
   Yang, Mingfu
   Wang, Anqi
   Foulsham, James E.
   Lan, Ke
TI Metabolic Profiling Assisted Quality Assessment of Rhodiola rosea
   Extracts by High-Performance Liquid Chromatography
SO PLANTA MEDICA
LA English
DT Article
DE metabolic profiling; Rhodiola rosea L. extracts; Crassulaceae family;
   quality assessment; high-performance liquid chromatography; fused-core
   column
ID FLIGHT MASS-SPECTROMETRY; FUSED-CORE PARTICLES; FINGERPRINT ANALYSIS;
   HERBAL EXTRACTS; GC-MS; HPLC; SINENSIS; IDENTIFICATION; COLUMNS; RRLC
AB In this work, fast and sensitive high-performance liquid chromatography (HPLC) coupled with multivariate analysis was utilized to assist the quality assessment of Rhodiola rosea extracts (RREs). 131 peaks were separated and detected in RREs on a fused-core C18 column. Principal component analysis (PCA) and hierarchical cluster analysis (HCA) of the chromatographic data demonstrated that 10 batches of RREs could be well-differentiated and categorized into three groups which were closely related to the origins of RREs. Partial least square-discriminant analysis (PLS-DA) showed that the quality differentiation might be explained by at least 6 components, in which rosavin was characterized by an external reference, rosiridine was identified by liquid chromatography-mass spectrometry (LC-MS), and the mass spectra of the others were provided. The observation that the level of rosavin was more relevant to the multivariate chromatographic data than the ones of salidroside and tyrosol, the other two components commonly used to standardize RREs, was confirmed by the PLS prediction models. Results of the present study not only indicated that rosavin was a rational marker to represent the quality of RREs, but also demonstrated the power of HPLC-based metabolic profiling in the quality assessment of herbal extracts.
C1 [Wang, Zhanguo; Chen, Fang] Sichuan Univ, Coll Life Sci, Chengdu 610065, Sichuan, Peoples R China.
   [Hu, Huiling] Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu, Sichuan, Peoples R China.
   [Zou, Liang] Chengdu Univ, Coll Biol Ind, Chengdu, Sichuan, Peoples R China.
   [Yang, Mingfu] Chengdu Wagott Pharmaceut Co Ltd, Chengdu, Sichuan, Peoples R China.
   [Wang, Anqi; Lan, Ke] Sichuan Univ, W China Sch Pharm, Minist Educ, Key Lab Drug Targeting & Drug Delivery Syst, Chengdu 610064, Sichuan, Peoples R China.
   [Foulsham, James E.] Univ Washington, Sch Med, Clin Fac, Seattle, WA USA.
   [Foulsham, James E.] Univ Washington, Seattle Childrens Hosp, Dept Pediat Orthoped Surg & Sports Med, Seattle, WA 98195 USA.
C3 Sichuan University; Chengdu University of Traditional Chinese Medicine;
   Chengdu University; Sichuan University; University of Washington;
   University of Washington Seattle; Seattle Children's Hospital;
   University of Washington; University of Washington Seattle
RP Chen, F (corresponding author), Sichuan Univ, Coll Life Sci, 24 S Sect,1 Yihuan Rd, Chengdu 610065, Sichuan, Peoples R China.
EM chenfang@scu.edu.cn; lanwoco@scu.edu.cn
RI ; Lan, Ke/B-5332-2010
OI Anqi, Wang/0000-0002-3369-1499; Lan, Ke/0000-0002-9237-9219
FU Foundation of Ministry of Education of China [200806101089]; China
   Postdoctoral Science Foundation [20100471649]
FX This study was supported by the PhD Programs Foundation of Ministry of
   Education of China (No. 200806101089) and the China Postdoctoral Science
   Foundation (20100471649). Five of the 10 total batches of RREs were
   kindly donated from the Maoxian Qiang Medicine Insititute (Maoxian,
   China).
CR Abrahim A, 2010, J PHARMACEUT BIOMED, V51, P131, DOI 10.1016/j.jpba.2009.08.023
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NR 31
TC 11
Z9 15
U1 0
U2 42
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0032-0943
EI 1439-0221
J9 PLANTA MED
JI Planta Med.
PD MAY
PY 2012
VL 78
IS 7
BP 740
EP 746
DI 10.1055/s-0031-1298373
PG 7
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA 939TM
UT WOS:000303838000015
PM 22441833
DA 2026-05-27
ER

PT J
AU Zhou, ZY
   Huang, Y
   Xiao, JC
   Liu, H
   Wang, YL
   Gong, ZP
   Li, YT
   Wang, AM
   Li, YJ
   Zheng, L
AF Zhou, Zu-Ying
   Huang, Yong
   Xiao, Jin-Chao
   Liu, Hui
   Wang, Yong-Lin
   Gong, Zi-Peng
   Li, Yue-Ting
   Wang, Ai-Min
   Li, Yong-Jun
   Zheng, Lin
TI Chemical profiling and quantification of multiple components in
   Jin-Gu-Lian capsule using a multivariate data processing approach based
   on UHPLC-Orbitrap Exploris 240 MS and UHPLC-MS/MS
SO JOURNAL OF SEPARATION SCIENCE
LA English
DT Article
DE chemical profiling; Jin-Gu-Lian capsule; multivariate statistical
   analysis; Orbitrap Exploris 240 mass spectrometry; quality control
AB The Jin-Gu-Lian capsule, a Chinese Miao herbal compound, is widely used to treat rheumatoid arthritis. In this study, a rapid, selective, and sensitive UHPLC-Orbitrap Exploris 240 MS method was developed to analyze the chemical composition of Jin-Gu-Lian capsules. A total of 88 compounds were identified, including 23 flavonoids, 23 organic acids, 14 phenylpropanoids, 12 phenols, eight alkaloids, four terpenes, three quinones, and one ketone. Among these, 21 compounds were clearly detected based on a comparison with reference standards and selected as quality control markers. Thereafter, these compounds were simultaneously determined in the Jin-Gu-Lian capsules. The established method was successfully validated and applied for the simultaneous determination of 21 biologically active compounds in Jin-Gu-Lian capsules of 27 sample batches. Quantitative data of the analytes were analyzed using multivariate statistical analysis to determine the quality of the Jin-Gu-Lian capsules. Four compounds (JGLC6 [salidroside], JGLC8 [chlorogenic acid], JGLC12 [liriodendrin], JGLC19 [quercetin]) were identified as chemical markers for quality control of Jin-Gu-Lian capsules. Altogether, the established method was validated as a novel and efficient tool, that can be used for rapid analysis of Jin-Gu-Lian capsules. Accordingly, this study serves as a reference for scientific research on traditional Chinese and ethnic medicine.
C1 [Zhou, Zu-Ying; Huang, Yong; Xiao, Jin-Chao; Liu, Hui; Wang, Yong-Lin; Gong, Zi-Peng; Li, Yue-Ting; Li, Yong-Jun; Zheng, Lin] Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guizhou Prov Key Lab Pharmaceut, Guiyang 550004, Peoples R China.
   [Wang, Ai-Min] Guizhou Med Univ, Engn Res Ctr Dev & Applicat Ethn Med & TCM, Minist Educ, Guiyang 550004, Peoples R China.
   [Zhou, Zu-Ying; Xiao, Jin-Chao; Liu, Hui] Guizhou Med Univ, Sch Pharmaceut, Guiyang 550004, Peoples R China.
C3 Guizhou Medical University; Guizhou Medical University; Guizhou Medical
   University
RP Li, YJ; Zheng, L (corresponding author), Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guizhou Prov Key Lab Pharmaceut, Guiyang 550004, Peoples R China.
EM liyongjun026@126.com; mailofzl@126.com
RI Wang, Yonglin/JFK-5415-2023; Wang, Aimin/AAH-1364-2019; Gong,
   Zipeng/AAD-2686-2019
OI Huang, Yong/0000-0002-4519-1192; Zhou, Zuying/0000-0003-4879-7621
FU National Key R&D Program of China [2018YFC1708100]; National Natural
   Science Foundation of China [81960763/U1812403]; Guizhou Science and
   Technology Department [[2019] 5407/5660, [2018]4006]; Guiyang Science
   and Technology Bureau [[2017]30-29]; 2020 National College Student
   Innovation and Entrepreneurship Training Program [10660-462]
FX National Key R&D Program of China, Grant/Award Number: 2018YFC1708100;
   NationalNatural Science Foundation of China, Grant/Award Number:
   81960763/U1812403; Guizhou Science and TechnologyDepartment, Grant/Award
   Numbers: [2019] 5407/5660, [2018]4006; Guiyang Science
   andTechnologyBureau, Grant/Award Number: [2017]30-29; 2020 National
   College Student Innovation and EntrepreneurshipTraining Program Project,
   Grant/Award Number: 10660-462
CR Administration NMP, 2002, BRAIN SYST MER LIMBS
   [Anonymous], 2003, ADM GMP, P308
   [Anonymous], 2003, ADM GMP, P146
   [Anonymous], 2020, COMMISSION CP, P480
   [Anonymous], 2003, ADM GMP, P11
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   [刘颖 Liu Ying], 2013, [中国药学杂志, Chinese Pharmaceutical Journal], V48, P2097
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   Zhou, 2013, CAP MED, V20, P63
NR 19
TC 14
Z9 15
U1 6
U2 58
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 1615-9306
EI 1615-9314
J9 J SEP SCI
JI J. Sep. Sci.
PD MAR
PY 2022
VL 45
IS 6
BP 1282
EP 1291
DI 10.1002/jssc.202100762
EA FEB 2022
PG 11
WC Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA ZZ6MH
UT WOS:000749368000001
PM 35060338
DA 2026-05-27
ER

PT J
AU Pkhaladze, L
   Davidova, N
   Khomasuridze, A
   Shengelia, R
   Panossian, AG
AF Pkhaladze, Lali
   Davidova, Nina
   Khomasuridze, Archil
   Shengelia, Ramaz
   Panossian, Alexander G.
TI Actaea racemosa L. Is More Effective in Combination with
   Rhodiola rosea L. for Relief of Menopausal Symptoms: A
   Randomized, Double-Blind, Placebo-Controlled Study
SO PHARMACEUTICALS
LA English
DT Article
DE black cohosh; rhodiola; menopause; clinical trial
ID INDUCED COGNITIVE IMPAIRMENT; STANDARDIZED EXTRACT SHR-5; BREAST-CANCER;
   ADAPTOGENS; SALIDROSIDE; CIMICIFUGA; THERAPY; RHIZOMA; ROOTS
AB Background: The aim of this study was to assess the efficacy and safety of a new herbal preparation (Menopause Relief EP(R)), the hybrid combination of Actaea racemosa L. (black cohosh, BC) and Rhodiola rosea L. (RR) root extracts, compared with the most effective dose of BC extract in women with menopausal complaints. Methods: A total of 220 women were randomly assigned to receive two capsules either BC (6.5 mg), BC500 (500 mg), Menopause Relief EP(R) (206,5), or placebo once per day for 12 weeks. The efficacy endpoints were relief of menopausal symptoms, measured using the Kupperman Menopausal Index (KMI), Menopause Relief Score (MRS), and menopause Utian Quality of Life (UQOL) index. Results: The menopause symptom relief effects of RR-BC were significantly superior in all tests to the effects of BC and placebo after their repeated administration for 6 and 12 weeks. There was no statistically significant difference between the effects of BC and BC500 over time. RR-BC significantly improved the QOL index in patients, compared to BC, BC500, and placebo, mainly due to the beneficial effects on the emotional and health domains. Conclusions: BC is more effective in combination with RR in relief of menopausal symptoms, particularly psychological symptoms.
C1 [Pkhaladze, Lali; Davidova, Nina; Khomasuridze, Archil] I Zhordania Inst Reproductol, 13 Tevdore Mghvdeli St, Tbilisi 0112, Georgia.
   [Shengelia, Ramaz] Tbilisi State Med Univ, Dept Hist Med & Bioeth, Vazha Pshavela Ave 33, Tbilisi 0162, Georgia.
   [Panossian, Alexander G.] Phytomed AB, Bofinkvagen 1, Vaxtorp, Sweden.
C3 Tbilisi State Medical University
RP Pkhaladze, L (corresponding author), I Zhordania Inst Reproductol, 13 Tevdore Mghvdeli St, Tbilisi 0112, Georgia.; Panossian, AG (corresponding author), Phytomed AB, Bofinkvagen 1, Vaxtorp, Sweden.
EM lpkhaladze@yahoo.com; davidovanino@gmail.com; archilk@list.ru;
   r.shengelia@tsmu.edu; ap@phytomed.se
RI Panossian, Alexander/AAK-8720-2021
OI Panossian, Alexander/0000-0002-8467-4525
FU Europharma USA, Green Bay, WI, USA; Terrence Lemerond, EuroPharma Inc.,
   USA [2018-02]
FX This research was funded by the Europharma USA, Green Bay, WI, USA. The
   sponsor of the of the research: Terrence Lemerond, EuroPharma Inc., USA,
   grant number 2018-02.
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NR 42
TC 11
Z9 11
U1 0
U2 6
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1424-8247
J9 PHARMACEUTICALS-BASE
JI Pharmaceuticals
PD MAY
PY 2020
VL 13
IS 5
AR 102
DI 10.3390/ph13050102
PG 31
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA LZ1ZS
UT WOS:000541028600026
PM 32455817
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Qi, TT
   Gu, GF
   Xu, L
   Xiao, M
   Lu, LL
AF Qi, Tingting
   Gu, Guofeng
   Xu, Li
   Xiao, Min
   Lu, Lili
TI Efficient synthesis of tyrosol galactosides by the β-galactosidase from
   Enterobacter cloacae B5
SO APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
LA English
DT Article
DE beta-galactosidase; Enterobacter cloacae B5; Transglycosylation; Tyrosol
   galactosides
ID LACTOBACILLUS-BULGARICUS L3; RHODIOLA-ROSEA L.; ENZYMATIC-SYNTHESIS;
   SALIDROSIDE PROTECTS; NATURAL-PRODUCTS; IN-VITRO; GLYCOSIDES;
   GLYCORANDOMIZATION; PATHWAY
AB In this work, the beta-galactosidase from Enterobacter cloacae B5 (BgaB5) exhibited excellent transglycosylation activity toward tyrosol (p-hydroxyphenethyl alcohol) when using lactose as the glycosyl donor, generating a series of tyrosol glycosides with potential pharmacological properties. The effects of substrate concentration, temperature, pH, and reaction time on the transglycosylation reaction catalyzed by the enzyme BgaB5 were studied in detail. Three tyrosol derivatives were produced in a total high yield of 50.0% when incubating the enzyme with 250 mM tyrosol and 1000 mM lactose (pH 7.5) at 50 A degrees C for 5 min. These derivatives were subsequently purified by column chromatography and preparative thin-layer chromatography. MS analysis of the purified compounds suggested one monogalactoside (M (r) 300) and two digalactoside derivatives (M (r) 462). The following NMR analysis further identified them to be p-hydroxyphenethyl beta-D-galactopyranoside, p-hydroxyphenethyl beta-D- galactopyranosyl-(1 -> 3')-beta-D-galactopyranoside, and p-hydroxyphenethyl beta-D- galactopyranosyl-(1 -> 6')-beta-D-galactopyranoside, respectively. The yield of the tyrosol monogalactoside which was known to possess potent bioactivities reached 39.4%, higher than other enzymatic yields reported so far. The two digalactosides, which were expected to have potential applications for novel drug screening and discovery, were artificially obtained with 10.6% yield for the first time.
C1 [Qi, Tingting; Gu, Guofeng; Xu, Li; Xiao, Min; Lu, Lili] Shandong Univ, Natl Glycoengn Res Ctr, Shandong Prov Key Lab Carbohydrate Chem & Glycobi, Jinan 250010, Peoples R China.
   [Lu, Lili] Huazhong Univ Sci & Technol, Sch Pharm, Tongji Med Coll, Hubei Key Lab Nat Med Chem & Res Evaluat, Wuhan 430030, Peoples R China.
C3 Shandong University; Huazhong University of Science & Technology
RP Xiao, M; Lu, LL (corresponding author), Shandong Univ, Natl Glycoengn Res Ctr, Shandong Prov Key Lab Carbohydrate Chem & Glycobi, Jinan 250010, Peoples R China.; Lu, LL (corresponding author), Huazhong Univ Sci & Technol, Sch Pharm, Tongji Med Coll, Hubei Key Lab Nat Med Chem & Res Evaluat, Wuhan 430030, Peoples R China.
EM minxiao@sdu.edu.cn; lililu@sdu.edu.cn
FU Science and Technology Development Project of Shandong Province
   [2015GSF121004, 2014GSF121006]; Fundamental Research Funds of Shandong
   University [2016JC028]
FX Science and Technology Development Project of Shandong Province (No.
   2015GSF121004, 2014GSF121006), National Natural Science Foundation of
   China (No. 31670062, No. 31000035), and Fundamental Research Funds of
   Shandong University (No. 2016JC028).
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NR 32
TC 25
Z9 27
U1 1
U2 28
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0175-7598
EI 1432-0614
J9 APPL MICROBIOL BIOT
JI Appl. Microbiol. Biotechnol.
PD JUN
PY 2017
VL 101
IS 12
BP 4995
EP 5003
DI 10.1007/s00253-017-8249-x
PG 9
WC Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology
GA EW7RN
UT WOS:000402712300014
PM 28361236
DA 2026-05-27
ER

PT J
AU Zhong, XL
   Zhong, YM
   Yan, KQ
   Xiao, XR
   Duan, L
   Wang, RL
   Wang, LY
AF Zhong, Xunlong
   Zhong, Yanmei
   Yan, Kangqi
   Xiao, Xuerong
   Duan, Lian
   Wang, Ruolun
   Wang, Laiyou
TI Metabolomics approach based on ultra-high-performance liquid
   chromatography coupled with quadrupole-time-of-flight mass spectrometry
   to identify the chemical constituents of the Traditional Chinese
   Er-Zhi-Pill
SO JOURNAL OF SEPARATION SCIENCE
LA English
DT Article
DE chemical constituents; Er-Zhi-Pill; metabolomics; traditional Chinese
   medicine
ID PHENOLIC-COMPOUNDS; LIGUSTRUM-LUCIDUM; MS
AB Er-Zhi-Pill, which consists of Ligustri lucidi fructus and Ecliptae prostratae herba, is a classical traditional Chinese medicinal formulation widely used as a liver-nourishing and kidney-enriching tonic. To identify the bioactive ingredients of ErZhi-Pill and characterize the variation of chemical constituents between co-decoction and mix of individually decocted L. lucidi fructus and E. prostratae herba, a novel metabolomics approach based on ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry in both positive and negative ion modes, was established to comprehensively analyze chemical constituents and probe distinguishable chemical markers. In total, 68 constituents were unambiguously or tentatively identified through alignment of accurate molecular weights within an error margin of 5 ppm, elemental composition and fragmentation characteristics, including eight constituents, which were confirmed by comparing to reference standards. Furthermore, principal component analysis and partial least squares discriminant analysis using Simca-p+ 12.0 software were applied to investigate chemical differences between formulations obtained by co-decoction and a mixture of individual decoctions. Global chemical differences were found in samples of two different decoction methods, and 16 components, including salidroside, specneuzhenide and wedelolactone, contributed most to the observed differences. This study provides a basic chemical profile for the quality control and further mechanism research of Er-Zhi-Pill.
C1 [Zhong, Xunlong; Duan, Lian; Wang, Ruolun] Guangzhou Med Univ, Affiliated Hosp 2, Dept Pharm, 250 Changgang East Rd, Guangzhou 510260, Guangdong, Peoples R China.
   [Zhong, Yanmei; Xiao, Xuerong] Guangdong Pharmaceut Univ, Cent Lab, Guangzhou, Guangdong, Peoples R China.
   [Yan, Kangqi] Guangzhou Baiyunshan Mingxing Pharmaceut Co Ltd, Res & Dev Dept, Guangzhou, Guangdong, Peoples R China.
   [Wang, Laiyou] Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou, Guangdong, Peoples R China.
C3 Guangzhou Medical University; Guangdong Pharmaceutical University;
   Guangdong Pharmaceutical University
RP Zhong, XL (corresponding author), Guangzhou Med Univ, Affiliated Hosp 2, Dept Pharm, 250 Changgang East Rd, Guangzhou 510260, Guangdong, Peoples R China.; Wang, LY (corresponding author), Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou, Guangdong, Peoples R China.
EM zsdx1985115@163.com; laiyouwang@hotmail.com
FU National Natural Science Foundation of China [81637689, 81403031];
   Foundation for Young Talents Innovation in Higher Education of Guangdong
   Province [2016KQNCX082]; Research Project of Medical Scientific
   Technique of Guangdong Province [A2015448, A2015585]
FX This work was supported by the National Natural Science Foundation of
   China (Grant Nos. 81637689 and 81403031), the Foundation for Young
   Talents Innovation in Higher Education of Guangdong Province (Grant No.
   2016KQNCX082), and Research Project of Medical Scientific Technique of
   Guangdong Province (Grant Nos. A2015448 and A2015585).
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NR 27
TC 17
Z9 20
U1 2
U2 72
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 1615-9306
EI 1615-9314
J9 J SEP SCI
JI J. Sep. Sci.
PD JUL
PY 2017
VL 40
IS 13
BP 2713
EP 2721
DI 10.1002/jssc.201601425
PG 9
WC Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA FB2UB
UT WOS:000405997600004
PM 28485887
DA 2026-05-27
ER

PT J
AU Niu, MM
   Li, Y
   Su, Q
   Chen, SY
   Li, QH
   Guo, HX
   Meng, XC
   Liu, F
AF Niu, Meng-Meng
   Li, Yan
   Su, Qian
   Chen, Si-Yuan
   Li, Qiao-Hui
   Guo, Huan-Xin
   Meng, Xiang-Chen
   Liu, Fei
TI A mannose-rich exopolysaccharide-1 isolated from
   Bifidobacterium breve mitigates ovalbumin-induced intestinal
   damage in mice by modulation CD4+T cell differentiation and inhibiting
   NF-κB signaling pathway
SO INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
LA English
DT Article
DE Exopolysaccharide; Intestinal barrier; Gut microbiota
ID SODIUM-INDUCED COLITIS; BARRIER FUNCTION; FOOD ALLERGY; MECHANISMS
AB Ovalbumin (OVA)-induced intestinal injury is a recurrent and potentially fatal condition. Previous studies have highlighted the roles of exopolysaccharides, particularly a mannose-rich (89.59 %) exopolysaccharide-1 (EPS-1) with a molecular weight of 39.9 kDa, isolated from Bifidobacterium breve H4-2, in repairing intestinal barriers and regulating immune responses. In this study, a mouse model of OVA-induced intestinal injury was used to investigate the effects of EPS-1 on intestinal barrier restoration. The results demonstrated that EPS-1 treatment (400 mg/kg. d) significantly reduced the allergic index (3.25 +/- 0.43) in OVA-challenged mice (p < 0.05), improved the physical integrity of the intestinal barrier by increasing mucin content and goblet cell number in the ileum (p < 0.05). EPS-1 treatment (400 mg/kg. d) also maintained immune barrier integrity by restoring imbalanced CD4 + T/CD8 + T ratios from 0.86 +/- 0.02 to 1.04 +/- 0.06, regulating Th1/Th2 and Th17/Treg cells balance, as well as inhibited the NF-kappa B signaling pathway. Furthermore, EPS-1 maintained microbiota homeostasis by increasing the abundances of Ruminococcus, Butyricicoccus, and Muribaculaceae, while reducing Streptococcus and Candidatus arthromitus. This microbiota modulation enhanced the levels of metabolites such as tyrosine, methionine, tryptophan, triglycerides, and salidroside. In conclusion, EPS-1 shows promise as a functional polysaccharide for therapeutic use.
C1 [Niu, Meng-Meng; Li, Yan; Su, Qian; Chen, Si-Yuan; Li, Qiao-Hui; Guo, Huan-Xin; Meng, Xiang-Chen; Liu, Fei] Northeast Agr Univ, Key Lab Dairy Sci, Minist Educ, Harbin 150030, Peoples R China.
C3 Northeast Agricultural University - China
RP Meng, XC; Liu, F (corresponding author), Northeast Agr Univ, Food Coll, Harbin 150030, Peoples R China.
EM xchmeng@163.com; david.as@163.com
RI 刘, 飞/HSH-9977-2023
FU National Natural Science Foundation of China [32072190, 32272291];
   Heilongjiang Province Key Research and Development Program (Innovation
   Base) [JD2023SJ15]
FX <BOLD>Funding</BOLD> This work was supported by grants from the National
   Natural Science Foundation of China (32072190, 32272291) and
   Heilongjiang Province Key Research and Development Program (Innovation
   Base) (No. JD2023SJ15) .
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NR 72
TC 5
Z9 7
U1 4
U2 51
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0141-8130
EI 1879-0003
J9 INT J BIOL MACROMOL
JI Int. J. Biol. Macromol.
PD NOV
PY 2024
VL 280
AR 135850
DI 10.1016/j.ijbiomac.2024.135850
EA SEP 2024
PN 3
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Applied; Polymer Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Polymer Science
GA I3Q9C
UT WOS:001329446600001
PM 39326613
DA 2026-05-27
ER

PT J
AU Song, YF
   Zhang, CY
   Wang, CX
   Zhao, L
   Wang, Z
   Dai, ZJ
   Lin, S
   Kang, HF
   Ma, XB
AF Song, Yafan
   Zhang, Chunyan
   Wang, Congxia
   Zhao, Ling
   Wang, Zheng
   Dai, Zhijun
   Lin, Shuai
   Kang, Huafeng
   Ma, Xiaobin
TI Ferulic Acid against Cyclophosphamide-Induced Heart Toxicity in Mice by
   Inhibiting NF-κB Pathway
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID ACUTE LUNG INJURY; INDUCED MYOCARDIAL-INFARCTION; HIGH-DOSE
   CYCLOPHOSPHAMIDE; TANSHINONE IIA SULFONATE; IN-VIVO; INDUCED
   CARDIOTOXICITY; CARDIAC TOXICITY; ASCORBIC-ACID; SALIDROSIDE;
   INFLAMMATION
AB The purpose of the present study was to elucidate the protective effects of ferulic acid (FA) against cyclophosphamide- (CTX-) induced changes in mice. Forty-eight male ICR mice were divided into four groups. Control group was intraperitoneally (i.p.) injected with 200 mu L of phosphate buffer saline (PBS). Model group was intraperitoneally injected with a single dose of CTX (200 mg/kg). FA (50 mg/kg) and FA (100 mg/kg) groups were intraperitoneally injected with a single dose of CTX (200 mg/kg) followed by the intragastric treatment with FA (50, 100 mg/kg) for 7 consecutive days. After 12 d, the mice were sacrificed to analyze the hematological, biochemical, histological parameters and mechanism research. The results indicated that FA significantly decreased the serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatine kinase (CK), lactate dehydrogenase (LDH), interleukin-6 (IL-6), IL-1 beta, and tumor necrosis factor-alpha (TNF-alpha) in CTX-injected mice. In addition, FA effectively reduced the total numbers of white blood cells (WBCs), red blood cells, platelets, and hemoglobin content. FA also obviously attenuated the histological changes of the heart tissues caused by CTX. Moreover, Western blot demonstrated that FA inhibited the phosphorylations of NF-kappa B signaling pathway in CTX-stimulated cardiac tissues. In conclusion, FA might be considered as an effective agent in the amelioration of the heart toxicity resulting from CTX treatment.
C1 [Song, Yafan; Zhang, Chunyan; Wang, Congxia; Zhao, Ling] Xi An Jiao Tong Univ, Sch Med, Affiliated Hosp 2, Dept Cardiol, Xian 710004, Peoples R China.
   [Wang, Zheng] Cent Hosp Xian, Dept Oncol, Xian 710003, Peoples R China.
   [Dai, Zhijun; Lin, Shuai; Kang, Huafeng; Ma, Xiaobin] Xi An Jiao Tong Univ, Sch Med, Affiliated Hosp 2, Dept Oncol, Xian 710004, Peoples R China.
C3 Xi'an Jiaotong University; Xi'an Jiaotong University
RP Kang, HF (corresponding author), Xi An Jiao Tong Univ, Sch Med, Affiliated Hosp 2, Dept Oncol, Xian 710004, Peoples R China.
EM kanghuafeng250@126.com; maxiaobin25@126.com
RI Dai, Zhi-Jun/O-6826-2014; Zhang, Chunyan/GVS-1674-2022; Ma,
   Xiaobin/O-7422-2017
OI Dai, Zhi-Jun/0000-0001-5209-8626; 
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NR 41
TC 42
Z9 45
U1 0
U2 22
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2016
VL 2016
AR 1261270
DI 10.1155/2016/1261270
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA DB2GF
UT WOS:000368325600001
PM 26881001
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Feng, YK
   Liu, ZZ
   Peng, Y
   Zhang, LH
   Ju, P
   Bi, KS
   Chen, XH
AF Feng, Yukun
   Liu, Zhenzhen
   Peng, Ying
   Zhang, Lunhui
   Ju, Ping
   Bi, Kaishun
   Chen, Xiaohui
TI Validated LC-MS method for simultaneous quantitation of catalpol and
   harpagide in rat plasma: application to a comparative pharmacokinetic
   study in normal and diabetic rats after oral administration of
   Zeng-Ye-Decoction
SO BIOMEDICAL CHROMATOGRAPHY
LA English
DT Article
DE catalpol; harpagide; Zeng-Ye-Decoction; diabetes mellitus;
   pharmacokinetics; LC-MS
ID COX-2 IN-VITRO; P-GLYCOPROTEIN; STREPTOZOTOCIN; EXPRESSION;
   CHROMATOGRAPHY; GLYCOSIDES
AB A simple and efficient liquid chromatography-mass spectrometry (LC-MS) method was developed and validated for simultaneous quantitation of catalpol and harpagide in normal and diabetic rat plasma. Protein precipitation extraction with acetonitrile was carried out using salidroside as the internal standard (IS). The LC separation was performed on an Elite C-18 column (150x4.6mm, 5 mu m) with the mobile phase consisting of acetonitrile and water within a runtime of 12.0min. The analytes were detected without endogenous interference in the selected ion monitoring mode with positive electrospray ionization. Calibration curves offered satisfactory linearity (r>0.99) at linear range of 0.05-50.0 mu g/mL for catalpol and 0.025-5.0 mu g/mL for harpagide with the lower limits of quantitation of 0.05 and 0.025 mu g/mL, respectively. Intra- and inter-day precisions (RSD) were <9.4%, and accuracy (RE) was in the -6.6 to 4.9% range. The extraction efficiencies of catalpol, harpagide and IS were all >76.5% and the matrix effects of the analytes ranged from 86.5 to 106.0%. The method was successfully applied to the pharmacokinetic study of catalpol and harpagide after oral administration of Zeng-Ye-Decoction to normal and diabetic rats, respectively. Copyright (c) 2013 John Wiley & Sons, Ltd.
C1 [Feng, Yukun; Liu, Zhenzhen; Peng, Ying; Zhang, Lunhui; Ju, Ping; Bi, Kaishun; Chen, Xiaohui] Shenyang Pharmaceut Univ, Shenyang, Peoples R China.
C3 Shenyang Pharmaceutical University
RP Chen, XH (corresponding author), Shenyang Pharmaceut Univ, Wenhua Rd 103, Shenyang, Peoples R China.
EM cxh_syphu@yahoo.com.cn
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NR 39
TC 21
Z9 25
U1 1
U2 29
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0269-3879
EI 1099-0801
J9 BIOMED CHROMATOGR
JI Biomed. Chromatogr.
PD NOV
PY 2013
VL 27
IS 11
BP 1503
EP 1510
DI 10.1002/bmc.2949
PG 8
WC Biochemical Research Methods; Biochemistry & Molecular Biology;
   Chemistry, Analytical; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Pharmacology & Pharmacy
GA 270NB
UT WOS:000328324100018
PM 23754598
DA 2026-05-27
ER

PT J
AU Ampong-Nyarko, K
   Lutz, S
   Sloley, BD
   Piquette, K
   Zhang, Z
AF Ampong-Nyarko, K.
   Lutz, S.
   Sloley, B. D.
   Piquette, K.
   Zhang, Z.
TI Assessments of soil productivity for roseroot (Rhodiola rosea L.)
   cultivation in Alberta
SO ZEITSCHRIFT FUR ARZNEI- & GEWURZPFLANZEN
LA English
DT Article
DE Fertilization; magnesium; phenylpropanoid glucoside; phenylpropenoids;
   potassium; Rhodiola rosea; yield
ID SECONDARY METABOLITES; POTASSIUM; QUALITY
AB Roseroot (Rhodiola rosea L.) is a valuable medicinal plant usually commercially sourced by wild crafting. Efforts are underway to bring roseroot under cultivation in Alberta. Understanding of roseroot adaptation to the environment is fundamental to its successful cultivation. The objectives of the study were to establish the functionally relevant soil parameters that affect roseroot root yield and production of bioactive compounds. The research was conducted over three years between 2005 and 2007. Soil and plant samples were taken from 21 farms between 2005 and 2007 to determine roseroot root yield as well as phenylpropanoid glucoside and phenylpropenoids content. Principal component analysis and multiple regressions were performed on the data. Seven principal components had eigenvalues >1 and accounted for 86.1% of the total variance in the data. Soil texture, sand, silt and potassium were functionally the most important soil parameters for roseroot root yield. Texture, sand, and silt had a positive relationship with roseroot root yield. Potassium level was negatively correlated to root yield. Highly significant positive correlation was observed between root sodium concentration and percent salidroside. We established that sandy loam soils low in potassium are best suited for roseroot cultivation and that excess potassium likely had antagonistic effect on magnesium absorption. A low soil temperature in early spring when roseroot growth is increasing rapidly further reduces the availability of magnesium to roseroot. The combination of soil information with recorded crop yield data allowed us to identify soil properties that were relevant to roseroot quality and yield.
C1 [Ampong-Nyarko, K.; Lutz, S.; Piquette, K.; Zhang, Z.] Alberta Agr & Rural Dev, Res & Innovat Div, Edmonton, AB T5Y 6H3, Canada.
   [Sloley, B. D.] Phytovox Inc, Edmonton, AB T5W 4E4, Canada.
RP Ampong-Nyarko, K (corresponding author), Alberta Agr & Rural Dev, Res & Innovat Div, 17507 Ft Rd, Edmonton, AB T5Y 6H3, Canada.
FU AVAC Ltd.; Alberta Agriculture and Rural Development
FX Authors thank AVAC Ltd and Alberta Agriculture and Rural Development for
   financial support. We also wish to thank the Alberta Rhodiola Rosea
   Growers Organization members who participated in the study. We thank
   George Turnbull and two anonymous reviewers for their helpful
   suggestions and comments.
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NR 25
TC 4
Z9 4
U1 1
U2 13
PU AGRIMEDIA GMBH
PI CLENZE
PA LUCHOWER STR 13A, CLENZE, 29459, GERMANY
SN 1431-9292
J9 Z ARZNEI- GEWURZPFLA
JI Z. Arznei- Gewurzpflanzen
PD DEC
PY 2011
VL 16
IS 4
BP 156
EP 162
PG 7
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences
GA 865UV
UT WOS:000298337300001
DA 2026-05-27
ER

PT J
AU Zhu, LP
   Nang, C
   Luo, F
   Pan, H
   Zhang, K
   Liu, JY
   Zhou, R
   Gao, J
   Chang, XY
   He, H
   Qiu, Y
   Wang, JL
   Long, HY
   Liu, Y
   Yan, TH
AF Zhu, Lingpeng
   Nang, Chen
   Luo, Fen
   Pan, Hong
   Zhang, Kai
   Liu, Jingyan
   Zhou, Rui
   Gao, Jin
   Chang, Xiayun
   He, He
   Qiu, Yue
   Wang, Jinglei
   Long, Hongyan
   Liu, Yu
   Yan, Tianhua
TI Esculetin attenuates lipopolysaccharide (LPS)-induced neuroinflammatory
   processes and depressive-like behavior in mice
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Esculetin; Lipopolysaccharide; Depression; Inflammation
ID ACUTE LUNG INJURY; KAPPA-B PATHWAY; IN-VITRO; NEUROTROPHIC FACTOR; MAJOR
   DEPRESSION; SALIDROSIDE; BRAIN; RATS; INFLAMMATION; CYTOKINES
AB Esculetin is one of the major bioactive compounds of Cichorium intybus L. The main purpose of the present study was to investigate the effects and possible underlying mechanism of esculetin (Esc) on lipopolysaccharide (LPS)induced neuroinflammatory processes and depressive-like behavior in mice. Mice were pretreatment with esculetin (Esc, 20, 40 mg/kg, intragastric administration) and a positive control drug fluoxetine (Flu, 20 mg/kg, intragastric administration) once daily for 7 consecutive days. At the 7th day, LPS (0.83 mg/kg) was intraperitoneal injection 30 min after drug administration. Higher dose (40 mg/kg) of esculetin and fluoxetine significantly decreased immobility time in TST and FST. There was no significant effect on locomotor activity in mice by the drugs. Esculetin significantly reduced LPS-induced elevated levels of pro-inflammatory cytokines including interleukin-6 (IL-6), interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) in serum and hippocampus. Esculetin attenuated inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein expression by inhibiting nuclear factor-kappa B (NF-kappa B) pathway in hippocampus. In addition, neuroprotection of esculetin was attributed to the upregulations of Brain derived neurotrophic factor (BDNF) and phosphorylated tyrosine kinase B (p-TrkB) protein expression in hippocampus. The obtained results demonstrated that esculetin exhibited antidepressant-like effects which might be related to the inhibition of NF-kappa B pathway and the activation of BDNF/TrkB signaling. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Zhu, Lingpeng; Wang, Jinglei; Liu, Yu] China Pharmaceut Univ, Sch Life Sci & Technol, Dept Biochem, Tongjiaxiang 24, Nanjing 210009, Jiangsu, Peoples R China.
   [Luo, Fen; Liu, Jingyan; Zhou, Rui; Gao, Jin; Chang, Xiayun; He, He; Yan, Tianhua] China Pharmaceut Univ, Dept Physiol & Pharmacol, Tongjiaxiang 24, Nanjing 210009, Jiangsu, Peoples R China.
   [Zhang, Kai] China Pharmaceut Univ, Dept Pharmacol Chinese Mat Med, Tongjiaxiang 24, Nanjing 210009, Jiangsu, Peoples R China.
   [Qiu, Yue] China Pharmaceut Univ, Sch Pharm, Tongjiaxiang 24, Nanjing 210009, Jiangsu, Peoples R China.
   [Pan, Hong] Environm Monitoring Stn Binhai, Zhongshizhonglu 105, Yancheng 224500, Peoples R China.
   [Long, Hongyan] Nanjing Univ TCM, Affiliated Hosp 3, Nanjing Municipal Hosp TCM, Cent Lab, Nanjing 210001, Jiangsu, Peoples R China.
   [Nang, Chen] Soochow Univ, Coll Med, Suzhou 215000, Peoples R China.
C3 China Pharmaceutical University; China Pharmaceutical University; China
   Pharmaceutical University; China Pharmaceutical University; Nanjing
   University of Chinese Medicine; Soochow University - China
RP Liu, Y (corresponding author), China Pharmaceut Univ, Sch Life Sci & Technol, Dept Biochem, Tongjiaxiang 24, Nanjing 210009, Jiangsu, Peoples R China.; Yan, TH (corresponding author), China Pharmaceut Univ, Dept Physiol & Pharmacol, Tongjiaxiang 24, Nanjing 210009, Jiangsu, Peoples R China.; Long, HY (corresponding author), Nanjing Univ TCM, Affiliated Hosp 3, Nanjing Municipal Hosp TCM, Cent Lab, Nanjing 210001, Jiangsu, Peoples R China.
EM hangyan3128@163.com; liuyuyaoda@163.com; yantianhuabest@126.com
RI zhou, rui/KZT-9353-2024; he, he/JPL-3505-2023; qiu, yue/IAN-7956-2023;
   Su, Tianyuan/Y-7054-2019
FU National Scientific & Technological major special Project "significant
   creation of new drugs" [2011ZX09102-002-01]
FX This study was supported by the National Scientific & Technological
   major special Project "significant creation of new drugs"
   (2011ZX09102-002-01).
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NR 40
TC 86
Z9 93
U1 0
U2 55
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD SEP 1
PY 2016
VL 163
BP 184
EP 192
DI 10.1016/j.physbeh.2016.04.051
PG 9
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA DS2KC
UT WOS:000380597400024
PM 27133730
DA 2026-05-27
ER

PT J
AU Xin, XB
   Yao, DH
   Zhang, K
   Han, S
   Liu, DN
   Wang, HY
   Liu, XY
   Li, GY
   Huang, J
   Wang, JH
AF Xin, Xiaobin
   Yao, Dahong
   Zhang, Ke
   Han, Shuai
   Liu, Danni
   Wang, Hangyu
   Liu, Xueying
   Li, Guoyu
   Huang, Jian
   Wang, Jinhui
TI Protective effects of Rosavin on bleomycin-induced pulmonary fibrosis
   via suppressing fibrotic and inflammatory signaling pathways in
   mice
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Rosavin; Bleomycin; Pulmonary fibrosis; Inflammatory response;
   Anti-oxidant
ID NF-KAPPA-B; OXIDATIVE STRESS; RHODIOLA-ROSEA; LUNG INJURY; RATS;
   COLLAGEN; NRF2; ATTENUATION; SALIDROSIDE; EXTRACT
AB Idiopathic Pulmonary fibrosis (IPF) is diagnosed as a life-threatening, progressive and incurable lung disease characterized by accumulation of extracellular matrix and myofibroblasts, resulting in the function degradation and structural alterations in normal lung parenchyma. Notably, Pulmonary Fibrosis has been considering as a difficult problem in clinical with high mortality and effective treatment strategies. Rosavin, a benzylPropylene glycoside, is isolated from Rhodiola rosea L., exhibiting nootropic, anti-depressant, anti-cancer, anti-inflammatory and anti-oxidative activities. In this study, we attended to elucidate the pharmacological activity of Rosavin for treatment of pulmonary fibrosis induced by bleomycin in mice. The results indicated that Rosavin could significantly ameliorate the lung index and Pathological structure of mice with Pulmonary fibrosis by bleomycin-induced. Additionally, Rosavin could evidently decreased inflammatory cells infiltration in bronch-oalveolar lavage fluid and pro-inflammatory cytokines expression in lung tissue specimens induced by bleomycin. Rosavin could down-regulate the expression of hydroxyproline and malondialdehyde and increased the activities of superoxide dismutase, glutathione peroxidase in lung tissue. The expression of Nrf2 were increased, and the expression of NF-kappa B p65, TGF-beta 1 and alpha-SMA were inhibited. The findings revealed the protective effects and the primary mechanism of rosavin on bleomycin-induced pulmonary fibrosis, which provided a scientific foundation for Rosavin as a promising candidate for Pulmonary fibrosis treatment.
C1 [Xin, Xiaobin; Zhang, Ke; Han, Shuai; Liu, Danni; Wang, Hangyu; Liu, Xueying; Li, Guoyu; Wang, Jinhui] Shihezi Univ, Coll Pharm, Key Lab Xinjiang Phytomed Resource & Utilizat, Minist Educ, Shihezi 832002, Peoples R China.
   [Yao, Dahong; Huang, Jian; Wang, Jinhui] Shenzhen Honghui Biopharmaceut Co Ltd, Shenzhen 518000, Peoples R China.
   [Yao, Dahong] Shenzhen Univ, Sch Med, Dept Pharmacol, Shenzhen 518060, Peoples R China.
C3 Shihezi University; Shenzhen University
RP Zhang, K; Wang, JH (corresponding author), Shihezi Univ, Coll Pharm, Key Lab Xinjiang Phytomed Resource & Utilizat, Minist Educ, Shihezi 832002, Peoples R China.
EM tcm_zk@suda.163.com; wangjinhui@hrbmu.edu.cn
RI Li, Guoyu/IQW-5262-2023; Liu, Danni/OOK-3293-2025; Wang,
   Jinhui/AAS-7317-2021
FU National Science and Technology Major Project for "Significant New Drugs
   Creation" [2017ZX090305005]
FX This work was supported by grants from National Science and Technology
   Major Project for "Significant New Drugs Creation" (No.
   2017ZX090305005).
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NR 51
TC 60
Z9 65
U1 1
U2 37
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD JUL
PY 2019
VL 115
AR 108870
DI 10.1016/j.biopha.2019.108870
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA IC0QJ
UT WOS:000470664600067
PM 31026730
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Concerto, C
   Infortuna, C
   Muscatello, MRA
   Bruno, A
   Zoccali, R
   Chusid, E
   Aguglia, E
   Battaglia, F
AF Concerto, Carmen
   Infortuna, Carmenrita
   Muscatello, Maria Rosaria Anna
   Bruno, Antonio
   Zoccali, Rocco
   Chusid, Eileen
   Aguglia, Eugenio
   Battaglia, Fortunato
TI Exploring the effect of adaptogenic Rhodiola Rosea extract on
   neuroplasticity in humans
SO COMPLEMENTARY THERAPIES IN MEDICINE
LA English
DT Article
DE Rhodiola rosea extract; Adaptogen; Transcranial magnetic stimulation;
   tDCS; Cortical plasticity; Stress
ID LONG-TERM DEPRESSION; DIRECT-CURRENT STIMULATION; HUMAN MOTOR CORTEX; L.
   EXTRACT; SYNAPTIC PLASTICITY; CLINICAL-TRIAL; CA2+ INFLUX; OPEN-LABEL;
   STRESS; SALIDROSIDE
AB Objectives: Rhodiola rosea extract is one of the most common herbal treatment for stress. Its mechanism of action in humans still need to be determined. We investigated the effect of a single dose intake of Rhodiola rosea extract on the plastic after-effects induced by anodal and cathodal motor cortex transcranial Direct Current Stimulation in humans.
   Methods: Twenty-eight healthy volunteers were required to intake 500 mg of either RRE or placebo. Transcranial Magnetic Stimulation was used to investigate cortical excitability. Motor threshold, recruitment of motor-evoked potentials, cortical silent period, short-interval intracortical inhibition and intracortical facilitation were assessed at different time points. Spinal excitability and peripheral nerve conduction were measured by F-response and M-wave. Furthermore, we assessed the modulation of cortical plasticity using transcranial direct current stimulation after-effects on Motor Evoked Potentials amplitudes.
   Results: Rhodiola rosea extract acute intake prevented cathodal transcranial Direct Current Stimulation-induced Long-term depression-like plasticity. The extract intake did not affect cortical excitability.
   Conclusions: Our findings suggest that a single oral dose of Rhodiola rosea extract intake modulates cortical plasticity in humans preventing the activity-dependent reduction in the efficacy of neuronal synapses. These results suggest that the adaptogenic and antidepressant effects of Rhodiola rosea extract might be based on its modulation of brain plasticity.
C1 [Concerto, Carmen; Battaglia, Fortunato] Sean Hall Univ, Hackensack Meridian Sch Med, Dept Med Sci Neurol & Psychiat, 340 Kingsland St,Bldg123,Room 4413, Nutley, NJ 07110 USA.
   [Chusid, Eileen] New York Coll Podiatr Med, Preclin Sci, New York, NY USA.
   [Infortuna, Carmenrita; Muscatello, Maria Rosaria Anna; Bruno, Antonio; Zoccali, Rocco] Univ Messina, Dept Biomed & Dent Sci & Morphofunct Imaging, Psychiat Unit, Messina, Italy.
   [Aguglia, Eugenio] Univ Catania, Psychiat Unit, Dept Clin & Expt Med, Catania, Italy.
C3 University of Messina; University of Catania
RP Battaglia, F (corresponding author), Sean Hall Univ, Hackensack Meridian Sch Med, Dept Med Sci Neurol & Psychiat, 340 Kingsland St,Bldg123,Room 4413, Nutley, NJ 07110 USA.
EM fortunato.battaglia@shu.edu
RI Muscatello, Maria/F-4205-2012; Concerto, Carmen/ABY-0612-2022
OI Concerto, Carmen/0000-0002-7426-5250; Infortuna,
   Carmenrita/0000-0003-3332-8996
CR [Anonymous], 2017, Lancet Psychiatry
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NR 63
TC 26
Z9 28
U1 1
U2 28
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0965-2299
EI 1873-6963
J9 COMPLEMENT THER MED
JI Complement. Ther. Med.
PD DEC
PY 2018
VL 41
BP 141
EP 146
DI 10.1016/j.ctim.2018.09.013
PG 6
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA HE6FF
UT WOS:000453498000020
PM 30477830
DA 2026-05-27
ER

PT J
AU Lan, Z
   Xie, GJ
   Wei, M
   Wang, P
   Chen, LY
AF Lan, Zhou
   Xie, Guangjing
   Wei, Meng
   Wang, Ping
   Chen, Lvyi
TI The protective effect of Epimedii Folium and Curculiginis Rhizoma on
   Alzheimer's disease by the inhibitions of NF-κB/MAPK pathway and NLRP3
   inflammasome
SO ONCOTARGET
LA English
DT Article
DE the water extracts of Epimedii Folium and Curculiginis Rhizoma (EX);
   Alzheimer's disease; amyloid beta; neuroinflammation; Gerotarget
ID ACUTE LUNG INJURY; AMELIORATING OXIDATIVE STRESS; INDUCED COGNITIVE
   DEFICITS; INDUCED RAT MODEL; IN-VIVO; BETA; SALIDROSIDE; NEUROTOXICITY;
   ACTIVATION; CHRYSOPHANOL
AB The purpose of the current study was to explore the effects of the water extracts of Epimedii Folium and Curculiginis Rhizoma (EX) on A beta-induced Alzheimer's disease. A beta(1-42) was stereotaxically injected bilaterally into the dorsal hippocampus, and then the rats were orally received EX at the doses of 2 g/kg and 6 g/kg for 30 days. Behavior was monitored through Morris water maze test. The neuroprotective effect of EX were examined with methods of histochemistry and biochemistry. EX reduced the contents of pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6) in hippocampus and cortex. EX also reduced the levels of malondialdehyde (MDA) and increased superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and glutathione peroxidase (GSH-Px) in the serum. Immunohistochemical analysis demonstrated that EX inhibited the expressions of NLRP3. In addition, we further confirmed that EX suppressed the expression of the NLRP3 inflammasome. EX inhibited the phosphorylations MAPKs, nuclear factor kappa B (NF-kappa B), myeloid differentiation factor 88(MyD88), cathepsin B. In conclusion, these results suggest that EX may be a potential agent for treating Alzheimer's disease.
C1 [Lan, Zhou; Wei, Meng] Hubei Univ Chinese Med, Sch Pharm, Wuhan, Peoples R China.
   [Xie, Guangjing; Wang, Ping] Hubei Univ Chinese Med, Sch Basic Med, Wuhan, Peoples R China.
   [Chen, Lvyi] South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan, Peoples R China.
C3 Hubei University of Chinese Medicine; Hubei University of Chinese
   Medicine; South Central Minzu University
RP Wang, P (corresponding author), Hubei Univ Chinese Med, Sch Basic Med, Wuhan, Peoples R China.; Chen, LY (corresponding author), South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan, Peoples R China.
EM pwang54@aliyun.com; clyhappy05@163.com
RI Chen, Lvyi/ACS-9198-2022; Wang, Ping/GZB-2001-2022; Lan,
   Zhou/AHD-7069-2022
FU National Natural Science Foundation of China [81303284, 81403157,
   81130064]; "Chenguang Planning" of the Natural Science Foundation of
   Wuhan City [2015070404010183]; China Postdoctoral Science Foundation
   [2015M571243, 2016T90193]
FX This work was supported by the National Natural Science Foundation of
   China (81303284, 81403157 and 81130064), the "Chenguang Planning" of the
   Natural Science Foundation of Wuhan City (2015070404010183), and China
   Postdoctoral Science Foundation (2015M571243 and 2016T90193).
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NR 40
TC 37
Z9 40
U1 0
U2 40
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
EI 1949-2553
J9 ONCOTARGET
JI Oncotarget
PD JUL 4
PY 2017
VL 8
IS 27
BP 43709
EP 43720
DI 10.18632/oncotarget.12574
PG 12
WC Oncology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Cell Biology
GA FA5QH
UT WOS:000405498000011
PM 28582770
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Mo, SS
   Wang, ZS
   Ding, DD
   Yan, ZZ
   Dai, YL
   Zhang, JC
   Liu, HF
   Liang, TJ
   Tong, JF
   Li, ZH
   Wang, XY
AF Mo, Shushan
   Wang, Zhaoshuo
   Ding, Dandan
   Yan, Zhengzheng
   Dai, Yunlu
   Zhang, Jinchao
   Liu, Huifang
   Liang, Tianjiao
   Tong, Jianfei
   Li, Zhenhua
   Wang, Xueyi
TI The synthesis and evaluation of novel BPA derivatives for enhanced
   blood-brain barrier penetration and boron neutron capture therapy
SO CHINESE CHEMICAL LETTERS
LA English
DT Article
DE Boron neutron capture therapy (BNCT); Novel BPA derivatives; Boron drug
   development; BBB penetration; Glioblastoma
ID P-BORONOPHENYLALANINE; FRUCTOSE INTAKE; VARIANTS
AB Boron neutron capture therapy (BNCT) has emerged as a promising treatment for cancers, offering a unique approach to selectively target tumor cells while sparing healthy tissues. Despite its clinical utility, the widespread use of fructose-BPA (F-BPA) has been hampered by its limited ability to penetrate the blood-brain barrier (BBB) and potential risks for patients with certain complications such as diabetes, hyperuricemia, and gout, particularly with substantial dosages. Herein, a series of novel BPA derivatives were synthesized. After the primary screening, geniposide-BPA (G-BPA) and salidroside-BPA (S-BPA) exhibited high water solubility, low cytotoxicity and safe profiles for intravenous injection. Furthermore, both G-BPA and S-BPA had demonstrated superior efficacy in vitro against the 4T1 cell line compared with F-BPA. Notably, S-BPA displayed optimal BBB penetration capability, as evidenced by in vitro BBB models and glioblastoma models in vivo , surpassing all other BPA derivative candidates. Meanwhile, GBPA also exhibited enhanced performance relative to the clinical drug F-BPA. In brief, G-BPA and S-BPA, as novel BPA derivatives, demonstrated notable safety profiles and remarkable boron delivery capabilities, thereby offering promising therapeutic options for BNCT in the clinic. (c) 2025 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
C1 [Mo, Shushan; Ding, Dandan; Yan, Zhengzheng; Li, Zhenhua; Wang, Xueyi] Southern Med Univ, Affiliated Hosp 10, Dongguan Peoples Hosp, Dongguan 523059, Peoples R China.
   [Mo, Shushan; Liu, Huifang] Hebei Univ, Coll Pharmaceut Sci, Key Lab Pharmaceut Qual Control Hebei Prov, Baoding 071002, Peoples R China.
   [Wang, Zhaoshuo] Spanish Natl Canc Res Ctr CNIO, Growth Factors Nutrients & Canc Grp, Madrid 28029, Spain.
   [Dai, Yunlu] Univ Macau, Fac Hlth Sci, Canc Ctr, Zhuhai 999078, Macau, Peoples R China.
   [Dai, Yunlu] Univ Macau, Inst Translat Med, Fac Hlth Sci, Zhuhai 999078, Macau, Peoples R China.
   [Zhang, Jinchao] Hebei Univ, Coll Chem & Mat Sci, Key Lab Med Chem & Mol Diag, State Key Lab New Pharmaceut Preparat & Excipients, Baoding 071002, Peoples R China.
   [Liang, Tianjiao; Tong, Jianfei] Spallat Neutron Source Sci Ctr, Dongguan 523803, Peoples R China.
C3 Southern Medical University - China; Hebei University; Centro Nacional
   de Investigaciones Oncologicas (CNIO); University of Macau; University
   of Macau; Hebei University; Chinese Academy of Sciences; Institute of
   High Energy Physics, CAS
RP Li, ZH; Wang, XY (corresponding author), Southern Med Univ, Affiliated Hosp 10, Dongguan Peoples Hosp, Dongguan 523059, Peoples R China.
EM zhenhuali@hbu.edu.cn; ixueyi@smu.edu.cn
RI ; Yan, Zheng-Zheng/KVB-9210-2024; wang, xueyi/OCL-7360-2025; Dai,
   Yunlu/AEL-3410-2022; tong, jianfei/IUO-8101-2023
OI Wang, Xueyi/0000-0003-3230-8176; Yan, Zheng-Zheng/0000-0003-3082-6762;
   Li, Zhenhua/0000-0001-9751-0864; 
FU Guangdong Basic and Ap-plied Basic Research Foundation
   [2021B1515120065]; National Natural Science Foundation of China
   [82202339, 32271420, 82202307]; China Postdoctoral Science Foundation
   [2022M711527, 2021M701640]; Science Fund for Creative Research Groups of
   Nature Science Foundation of Hebei Province [B2021201038]; National
   High-End Foreign Expert Recruitment Plan [G20220 030 07L]; Natural
   Science Foundation of Hebei Province [B2023201108]
FX This work was supported by Guangdong Basic and Ap-plied Basic Research
   Foundation (No. 2021B1515120065) , National Natural Science Foundation
   of China (Nos. 82202339 , 32271420 , 82202307) , China Postdoctoral
   Science Foundation (Nos. 2022M711527 , 2021M701640) , Science Fund for
   Creative Research Groups of Nature Science Foundation of Hebei Province
   (No. B2021201038) , National High-End Foreign Expert Recruitment Plan
   (No. G20220 030 07L) , Natural Science Foundation of Hebei Province (No.
   B2023201108) .
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NR 32
TC 2
Z9 3
U1 11
U2 35
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1001-8417
EI 1878-5964
J9 CHINESE CHEM LETT
JI Chin. Chem. Lett.
PD MAY
PY 2025
VL 36
IS 5
AR 110190
DI 10.1016/j.cclet.2024.110190
EA MAR 2025
PG 6
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA 0JI4M
UT WOS:001448745400001
DA 2026-05-27
ER

PT J
AU Li, ST
   Zhuang, YY
   Ji, Y
   Chen, XW
   He, LY
   Chen, SJ
   Luo, YT
   Shen, LY
   Xiao, J
   Wang, HZ
   Luo, CW
   Peng, FF
   Long, HB
AF Li, Shuting
   Zhuang, Yiyi
   Ji, Yue
   Chen, Xiaowen
   He, Liying
   Chen, Sijia
   Luo, Yating
   Shen, Lingyu
   Xiao, Jing
   Wang, Huizhen
   Luo, Congwei
   Peng, Fenfen
   Long, Haibo
TI BRG1 accelerates mesothelial cell senescence and peritoneal fibrosis by
   inhibiting mitophagy through repression of OXR1
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Peritoneal fibrosis; Brahma -related gene 1; Mesothelial-to-mesenchymal
   transition; Oxidation resistance 1; Mitophagy; Peritoneal dialysis
ID OXIDATIVE STRESS; MESENCHYMAL TRANSITION; HIGH GLUCOSE; DIALYSIS;
   GROWTH; TRANSPORT; MEMBRANE; EFFLUENT; CONTRIBUTES; ACTIVATION
AB Peritoneal mesothelial cell senescence promotes the development of peritoneal dialysis (PD) -related peritoneal fibrosis. We previously revealed that Brahma -related gene 1 (BRG1) is increased in peritoneal fibrosis yet its role in modulating peritoneal mesothelial cell senescence is still unknown. This study evaluated the mechanism of BRG1 in peritoneal mesothelial cell senescence and peritoneal fibrosis using BRG1 knockdown mice, primary peritoneal mesothelial cells and human peritoneal samples from PD patients. The augmentation of BRG1 expression accelerated peritoneal mesothelial cell senescence, which attributed to mitochondrial dysfunction and mitophagy inhibition. Mitophagy activator salidroside rescued fibrotic responses and cellular senescence induced by BRG1. Mechanistically, BRG1 was recruited to oxidation resistance 1 (OXR1) promoter, where it suppressed transcription of OXR1 through interacting with forkhead box protein p2. Inhibition of OXR1 abrogated the improvement of BRG1 deficiency in mitophagy, fibrotic responses and cellular senescence. In a mouse PD model, BRG1 knockdown restored mitophagy, alleviated senescence and ameliorated peritoneal fibrosis. More importantly, the elevation level of BRG1 in human PD was associated with PD duration and D/P creatinine values. In conclusion, BRG1 accelerates mesothelial cell senescence and peritoneal fibrosis by inhibiting mitophagy through repression of OXR1. This indicates that modulating BRG1-OXR1-mitophagy signaling may represent an effective treatment for PD -related peritoneal fibrosis.
C1 [Li, Shuting; Zhuang, Yiyi; Ji, Yue; Chen, Xiaowen; He, Liying; Luo, Yating; Shen, Lingyu; Xiao, Jing; Wang, Huizhen; Luo, Congwei; Peng, Fenfen; Long, Haibo] Southern Med Univ, Zhujiang Hosp, Dept Nephrol, Guangzhou 510280, Peoples R China.
   [Li, Shuting] Southern Med Univ, Shunde Hosp, Peoples Hosp Shunde 1, Dept Nephrol, Foshan, Peoples R China.
   [Chen, Sijia] First Hosp Changsha, Dept Nephrol & Rheumatol, Changsha, Peoples R China.
C3 Southern Medical University - China; Southern Medical University - China
RP Luo, CW; Peng, FF; Long, HB (corresponding author), Southern Med Univ, Zhujiang Hosp, Dept Nephrol, Guangzhou 510280, Peoples R China.
EM 116505078@qq.com; doctorpff@163.com; longhb1966@163.com
RI he, liying/GZK-4618-2022; Peng, Fenfen/ISA-9238-2023; Xiao,
   Jing/OIT-3094-2025
FU Natural Science Foundation of Guangdong Province, China
   [2022A1515012665, 2019A1515011083, 2021A1515010008]; National Natu- ral
   Science Foundation of China (NSFC) [81900607, 82071563, 82000682]
FX This work was supported by the Natural Science Foundation of Guangdong
   Province, China (no.2022A1515012665, no.2019A1515011083 and
   no.2021A1515010008) , the National Natu- ral Science Foundation of China
   (NSFC) (no.81900607, no.82071563, and no. 82000682) .
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NR 69
TC 6
Z9 8
U1 1
U2 18
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD MAR
PY 2024
VL 214
BP 54
EP 68
DI 10.1016/j.freeradbiomed.2024.01.054
EA FEB 2024
PG 15
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA LB6I1
UT WOS:001184352300001
PM 38311259
DA 2026-05-27
ER

PT J
AU Xue, ZZ
   Xu, LL
   Shang, ZP
   Shi, XM
   Ye, M
   Qiao, X
AF Xue, Zhenzhen
   Xu, Lulu
   Shang, Zhanpeng
   Shi, Xiaomeng
   Ye, Min
   Qiao, Xue
TI Discovery of minor quality evaluation marker compounds for Chinese
   patent medicine products using a two-leveled metabolomics strategy
SO JOURNAL OF CHROMATOGRAPHY A
LA English
DT Article
DE Chinese patent medicines; Marker compounds; Quality evaluation;
   Two-leveled metabolomics; Zhenqi Fuzheng granule
ID HYBRID QUADRUPOLE-ORBITRAP; FRUCTUS-LIGUSTRI-LUCIDI; QUANTIFICATION;
   IDENTIFICATION; CONSTITUENTS; COMPONENTS; DECOCTION; FRUITS; HPLC; TOF
AB Chinese patent medicines (CPMs) are popularly used in clinical practice. Though the composition is complex, the quality of CPM is usually evaluated by the contents of a few main compounds. In this study, a two-leveled metabolomics strategy was proposed to discover minor marker compounds for different CPM products. Zhenqi Fuzheng (ZQFZ) granule was studied an example, where 15 batches from 3 producers were analyzed. The samples were separated using UHPLC on an Acquity UPLC (R) HSS T3 column, and then detected using Q-Orbitrap-MS. In the first level, 1475 common peaks were extracted and 95 compounds were identified using diagnostic ions and a homemade database. In the second level, the data were subjected to a two-way hierarchical clustering analysis and screened by variable importance value. In total 14 marker compounds were discovered which were responsible for the grouping of different ZQFZ products. Echinacoside (22), oleoside (13), loganic acid (5), salidroside (7), ligustrosidic acid (42), 6 alpha-hydroxygeniposide (28), and oleoside 11-methyl ester (15) could be used to reflect the quality difference for ZQFZ granule products. The proposed strategy could also contribute to the discovery of quality control markers for other CPMs. (C) 2021 Elsevier B.V. All rights reserved.
C1 [Xue, Zhenzhen; Xu, Lulu; Shang, Zhanpeng; Shi, Xiaomeng; Ye, Min; Qiao, Xue] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, 38 Xueyuan Rd, Beijing 100191, Peoples R China.
   [Qiao, Xue] Peking Univ, Sch Basic Med Sci, Dept Integrat Chinese & Western Med, Beijing 100191, Peoples R China.
C3 Peking University; Peking University
RP Ye, M; Qiao, X (corresponding author), Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, 38 Xueyuan Rd, Beijing 100191, Peoples R China.; Qiao, X (corresponding author), Peking Univ, Sch Basic Med Sci, Dept Integrat Chinese & Western Med, Beijing 100191, Peoples R China.
EM yemin@bjmu.edu.cn; qiaoxue@bjmu.edu.cn
RI ; Qiao, Xue/NQF-2040-2025; shang, zhanpeng/JBI-9745-2023
OI Zhenzhen, Xue/0000-0002-8719-6119; Ye, Min/0000-0002-9952-2380; 
FU National Key Research and Development Program of China [2018YFC1707905,
   2018YFC1707904, 2018YFC1707900]; Beijing Natural Science Foundation
   [JQ18027]; National Natural Science Foundation of China [81725023];
   China Postdoctoral Science Foundation [2019M660370]
FX The work was supported by the National Key Research and Development
   Program of China (No. 2018YFC1707905, 2018YFC1707904, 2018YFC1707900) ,
   Beijing Natural Science Foundation (JQ18027) , National Natural Science
   Foundation of China (No. 81725023) , and China Postdoctoral Science
   Foundation (2019M660370) . We thank Xiuzheng Pharmaceutical Group
   (China) for providing part of the samples.
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Z9 13
U1 2
U2 50
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0021-9673
EI 1873-3778
J9 J CHROMATOGR A
JI J. Chromatogr. A
PD AUG 30
PY 2021
VL 1652
AR 462354
DI 10.1016/j.chroma.2021.462354
EA JUN 2021
PG 9
WC Biochemical Research Methods; Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA TL1JU
UT WOS:000674612100002
PM 34214834
DA 2026-05-27
ER

PT J
AU Kan, JX
   Zhu, JP
   Wei, T
   Chen, H
AF Kan, Jia-Xin
   Zhu, Jian-Ping
   Wei, Ting
   Chen, Han
TI Natural Products Ameliorate Non-Alcoholic Fatty Liver Disease and
   Atherosclerosis via the LKB1/AMPK Pathway
SO NATURAL PRODUCT COMMUNICATIONS
LA English
DT Review
DE Phytotherapy; LKB1/AMPK pathway; liver-vascular axis;
   metabolic-inflammatory network; comorbidity
ID ACTIVATED PROTEIN-KINASE; ENDOTHELIAL DYSFUNCTION; HEPATIC STEATOSIS;
   SUBCLINICAL ATHEROSCLEROSIS; INSULIN-RESISTANCE; AMPK; RESVERATROL;
   METABOLISM; CELL; PHARMACOKINETICS
AB Non-alcoholic fatty liver disease (NAFLD) and atherosclerosis (AS) are two major phenotypes of metabolic syndrome that frequently coexist through a "liver-vascular axis" characterized by lipid dysregulation, chronic inflammation, and mitochondrial dysfunction. The liver kinase B1/AMP-activated protein kinase (LKB1/AMPK) signaling pathway, acting as a master regulator of energy and redox balance, has emerged as a central hub in this comorbidity. Activation of this pathway suppresses lipogenesis, enhances fatty acid oxidation, attenuates inflammation, and improves endothelial function, thereby interrupting the vicious metabolic-inflammatory cycle underlying NAFLD and AS. Natural products provide promising multi-target modulators of LKB1/AMPK. Polyphenols (such as curcumin, resveratrol, quercetin), terpenoids (such as nobiletin, betulinic acid), alkaloids (such as berberine), and glycosides (such as ginsenosides, salidroside) restore lipid homeostasis, induce autophagy, regulate oxidative stress, and modulate immune responses via LKB1/AMPK and its crosstalk with sirtuin 1 (SIRT1), peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1 alpha), and mammalian target of rapamycin (mTOR) signaling. Preclinical studies highlight their ability to improve hepatic steatosis, vascular inflammation, and plaque stability, underscoring their cross-organ therapeutic potential. However, pharmacological translation remains limited by poor bioavailability, variable pharmacokinetics, species differences, and inconsistent clinical outcomes. This review systematically summarizes comorbidity mechanisms of NAFLD and AS, regulatory roles of the LKB1/AMPK pathway, therapeutic actions of representative natural products, and the challenges ahead, aiming to guide precision strategies for metabolic syndromes.
C1 [Kan, Jia-Xin; Zhu, Jian-Ping] Hunan Univ Chinese Med, Sch Tradit Chinese Med, Changsha 410208, Peoples R China.
   [Zhu, Jian-Ping; Wei, Ting; Chen, Han] HeiLongJiang Univ Chinese Med, Sch Basic Med Sci, Harbin 150000, Peoples R China.
C3 Hunan University of Chinese Medicine; Heilongjiang University of Chinese
   Medicine
RP Zhu, JP (corresponding author), HeiLongJiang Univ Chinese Med, Sch Basic Med Sci, Harbin 150000, Peoples R China.
EM 570675111@qq.com
RI zhu, jianping/IVV-5085-2023
FU University-level Scientific Research Project Funded by Hunan University
   of Chinese Medicine [2024XJZC017]; Scientific Research Project Funded by
   Hunan Provincial Department of Education [23B0375]; Hunan Provincial
   Training Program for Young Core Teachers in Higher Education
   Institutions
FX The authors disclosed receipt of the following financial support for the
   research, authorship, and/or publication of this article: This work was
   supported by the Hunan Provincial Training Program for Young Core
   Teachers in Higher Education Institutions, University-level Scientific
   Research Project Funded by Hunan University of Chinese Medicine,
   Scientific Research Project Funded by Hunan Provincial Department of
   Education, (grant number 2024XJZC017, 23B0375).
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NR 190
TC 3
Z9 3
U1 21
U2 26
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1934-578X
EI 1555-9475
J9 NAT PROD COMMUN
JI Nat. Prod. Commun.
PD NOV
PY 2025
VL 20
IS 11
AR 1934578X251394620
DI 10.1177/1934578X251394620
PG 21
WC Chemistry, Medicinal; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology
GA 9HH7C
UT WOS:001606347900001
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Hsu, SW
   Chang, TC
   Wu, YK
   Lin, KT
   Shi, LS
   Lee, SY
AF Hsu, Shih-Wei
   Chang, Tsu-Chung
   Wu, Yu-Kuan
   Lin, Kuen-Tze
   Shi, Li-Shian
   Lee, Shih-Yu
TI Rhodiola crenulata extract counteracts the effect of hypobaric
   hypoxia in rat heart via redirection of the nitric oxide and
   arginase 1 pathway
SO BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
DE Rhodiola crenulata; Hypobaric hypoxia; Heart; Nitric oxide; Arginase 1
ID OXIDATIVE STRESS; HIGH-ALTITUDE; ACTIVATION; APOPTOSIS; DISEASE;
   AVAILABILITY; SALIDROSIDE; PROTECTION; CELLS; MICE
AB Background: Rhodiola crenulata is traditionally used as a folk medicine in Tibet for preventing high-altitude illnesses, including sudden cardiac death (SCD). The cardio-protective effects of Rhodiola crenulata root extract (RCE) against hypoxia in vivo have been recently confirmed. However, the way in which RCE produces these effects remains unclear. The present study is designed to confirm the protective effects of RCE on the heart in acute hypobaric hypoxia exposure and examine the mechanisms by which this occurs.
   Methods: Sprague-Dawley (SD) rats were pretreated with or without RCE and then exposed to a simulated altitude of 8000 m in a hypobaric hypoxia chamber for 9 h. The expression of cardiac arginase 1 (Arg-1) and endothelial nitric oxide synthase (eNOS) and the activity of associated signaling pathways was examined.
   Results: Hypoxia reduced cardiac eNOS phosphorylation and increased Arg-1 expression, but both responses were reversed by RCE pre-treatment. In addition, RCE decreased the hypoxia-induced oxidative stress markers of reactive oxygen species (ROS) production, malondialdehyde (MDA) level, and protein carbonyl content. Furthermore, RCE protected cardiomyocytes from hypoxia-induced cardiac apoptosis and restored the phosphorylation level of AKT and p38 MAPK as well as the superoxide dismutase 2 (SOD2) content in hypoxic animals.
   Conclusion: The findings provide evidence that the effects of Rhodiola crenulata against altitude illness are partially mediated by modulation of eNOS and Arg-1 pathways in the heart.
C1 [Hsu, Shih-Wei] Taichung Armed Forces Gen Hosp, Dept Neurosurg, Taichung, Taiwan.
   [Chang, Tsu-Chung; Wu, Yu-Kuan] Natl Def Med Ctr, Dept Biochem, Taipei, Taiwan.
   [Lin, Kuen-Tze] Triserv Gen Hosp, Dept Radiat Oncol, Natl Def Med Ctr, Taipei, Taiwan.
   [Shi, Li-Shian] Natl Formosa Univ, Dept Biotechnol, Yunlin, Taiwan.
   [Lee, Shih-Yu] Natl Def Med Ctr, Grad Inst Aerosp & Undersea Med, POB 90048-514, Taipei 114, Taiwan.
C3 National Defense Medical University; Tri-Service General Hospital;
   National Defense Medical University; National Formosa University;
   National Defense Medical University
RP Lee, SY (corresponding author), Natl Def Med Ctr, Grad Inst Aerosp & Undersea Med, POB 90048-514, Taipei 114, Taiwan.
EM leeshihyuno1@mail.ndmctsgh.edu.tw
RI Lee, Shih-Yu/AAO-4110-2020
OI Lee, Shih-Yu/0000-0002-4713-6410
FU Ministry of Science and Technology, Taipei, Taiwan, ROC [MOST
   104-2320-B-016-003]; Ministry of National Defense, Taipei, Taiwan, ROC
   [MAB-104-017, MAB-105-007]
FX The Ministry of Science and Technology (MOST 104-2320-B-016-003 to S.-Y.
   L.) and the Ministry of National Defense (MAB-104-017 and MAB-105-007 to
   S.-Y. L.), Taipei, Taiwan, ROC.
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NR 35
TC 24
Z9 32
U1 6
U2 33
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6882
J9 BMC COMPLEM ALTERN M
JI BMC Complement. Altern. Med.
PD JAN 7
PY 2017
VL 17
AR 29
DI 10.1186/s12906-016-1524-z
PG 10
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA EI2WM
UT WOS:000392349100004
PM 28061780
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhou, P
   Ma, YY
   Zhao, XN
   Hua, F
AF Zhou, Peng
   Ma, Yao-yao
   Zhao, Xiao-ni
   Hua, Fang
TI Phytochemicals as potential target on thioredoxin-interacting protein
   (TXNIP) for the treatment of cardiovascular diseases
SO INFLAMMOPHARMACOLOGY
LA English
DT Review
DE Cardiovascular disease; TXNIP; Flavonoids; Phenols; Alkaloids; Molecular
   docking
ID ISCHEMIA-REPERFUSION INJURY; NF-KAPPA-B; MYOCARDIAL ISCHEMIA/REPERFUSION
   INJURY; OXIDATIVE STRESS; MITOCHONDRIAL-FUNCTION; ISCHAEMIA/REPERFUSION
   INJURY; INFLAMMASOME ACTIVATION; ENDOTHELIAL DYSFUNCTION; INDUCED
   APOPTOSIS; ROSMARINIC ACID
AB Cardiovascular diseases (CVDs) are currently the major cause of death and morbidity on a global scale. Thioredoxin-interacting protein (TXNIP) is a marker related to metabolism, oxidation, and inflammation induced in CVDs. The overexpression of TXNIP is closely related to the occurrence and development of CVDs. Hence, TXNIP inhibition is critical for reducing the overactivation of its downstream signaling pathway and, as a result, myocardial cell damage. Due to the chemical variety of dietary phytochemicals, they have garnered increased interest for CVDs prevention and therapy. Phytochemicals are a source of medicinal compounds for a variety of conditions, which aids in the development of effective and safe TXNIP-targeting medications. The objective of this article is to find and virtual screen novel safe, effective, and economically viable TXNIP inhibitors from flavonoids, phenols, and alkaloids derived from foods and plants. The results of the docking study revealed that silibinin, rutin, luteolin, baicalin, procyanidin B2, hesperetin, icariin, and tilianin in flavonoids, polydatin, resveratrol, and salidroside in phenols, and neferine in alkaloids had the highest Vina scores, indicating that these compounds are the active chemicals on TXNIP. In particular, silibinin can be utilized as a lead chemical in the process of structural alteration. These dietary phytochemicals may aid in the discovery of lead compounds for the development of innovative TXNIP agents for the treatment of cardiovascular disease.
C1 [Zhou, Peng; Ma, Yao-yao; Zhao, Xiao-ni] Anhui Univ Chinese Med, Dept Integrated Tradit Chinese & Western Med, Hefei, Anhui, Peoples R China.
   [Hua, Fang] Anhui Xinhua Univ, Sch Pharm, Hefei, Anhui, Peoples R China.
C3 Anhui University of Chinese Medicine; Anhui Xinhua University
RP Hua, F (corresponding author), Anhui Xinhua Univ, Sch Pharm, Hefei, Anhui, Peoples R China.
EM happyhf6941@sina.com
FU Key Project Foundation of Natural Science Research in Universities of
   Anhui Province in China [2022AH050479, KJ2021A1167]; Outstanding Youth
   Scientific Research Project of Anhui Universities [2022AH030158]; Open
   Fund of State Key Laboratory of Tea Plant Biology and Utilization
   [SKLTOF20210112]
FX This work was financially supported by the Key Project Foundation of
   Natural Science Research in Universities of Anhui Province in China
   (2022AH050479 and KJ2021A1167), Outstanding Youth Scientific Research
   Project of Anhui Universities (2022AH030158), and Open Fund of State Key
   Laboratory of Tea Plant Biology and Utilization (SKLTOF20210112).
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NR 158
TC 10
Z9 10
U1 2
U2 26
PU SPRINGER BASEL AG
PI BASEL
PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
SN 0925-4692
EI 1568-5608
J9 INFLAMMOPHARMACOLOGY
JI Inflammopharmacology
PD FEB
PY 2023
VL 31
IS 1
BP 207
EP 220
DI 10.1007/s10787-022-01130-8
EA JAN 2023
PG 14
WC Immunology; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy; Toxicology
GA CD6I2
UT WOS:000910809100001
PM 36609715
DA 2026-05-27
ER

PT J
AU Wang, CX
   Xing, YC
   Ding, H
   Wang, P
   Zhang, LH
   Fu, ZF
   Han, LF
   Pang, X
AF Wang, Chenxi
   Xing, Yanchao
   Ding, Hui
   Wang, Ping
   Zhang, Lihua
   Fu, Zhifei
   Han, Lifeng
   Pang, Xu
TI Multiple component-pharmacokinetic studies on 10 bioactive constituents
   of Peiyuan Tongnao capsule using parallel reaction monitoring mode
SO BIOMEDICAL CHROMATOGRAPHY
LA English
DT Article
DE multiple components-pharmacokinetic study; parallel reaction monitoring;
   Peiyuan Tongnao capsule; UHPLC/Q-Orbitrap-MS
ID MASS-SPECTROMETRY; RAT PLASMA; MS/MS; MEDICINE; MS
AB Peiyuan Tongnao capsule (PTC) plays an important role in clinical application due to its excellent curative efficacy in the treatment of ischemic stroke and chronic cerebral circulation insufficiency. To standardize and rationalize the clinical application of PTC, a rapid and sensitive method based on ultra-high performance liquid chromatography/quadrupole-Orbitrap mass spectrometry with parallel reaction monitoring (PRM) mode was developed and validated for the pharmacokinetic (PK) study. Ten bioactive compounds (aucubin, salidroside, echinacoside, paeoniflorin, verbascoside, liquiritin, 2,3,5,4'-tetrahydroxy stilbene-2-O-beta-d-glucoside, coumarin, glycyrrhizic acid, and emodin) were simultaneously determined in rat plasma. All calibration curves exhibited good linearity (r(2) > 0.99). The lower limits of quantification were 0.082-13.291 ng mL(-1). The intra- and inter-day precision was 0.54-12.36%, whereas the intra- and inter-day accuracy ranged from 100.45 to 114.00%. The mean extraction recoveries were 81.77-117.66%, and the average matrix effects (MEs) were 86.23-109.96%. The high extraction recoveries and acceptable MEs indicated that the pretreatment method was feasible. And the stability was acceptable under various storage conditions and processing procedures. The validated method was successfully applied to the multiple components-PK studies, which lay the foundation for further pharmacological and clinical research of PTC and may provide a reference for other traditional Chinese medicines.
C1 [Wang, Chenxi; Xing, Yanchao; Ding, Hui; Zhang, Lihua; Fu, Zhifei; Han, Lifeng; Pang, Xu] Tianjin Univ Tradit Chinese Med, Tianjin Key Lab TCM Chem & Anal, State Key Lab Component Based Chinese Med, Tianjin 301617, Peoples R China.
   [Wang, Ping] Henan Lingrui Pharmaceut Co Ltd, Xinyang, Peoples R China.
C3 Tianjin University of Traditional Chinese Medicine
RP Fu, ZF; Pang, X (corresponding author), Tianjin Univ Tradit Chinese Med, Tianjin Key Lab TCM Chem & Anal, State Key Lab Component Based Chinese Med, Tianjin 301617, Peoples R China.
EM fuzhifei@tjutcm.edu.cn; pangxu320@163.com
RI wang, chenxi/HMD-9902-2023
FU National Key R&D Program of China [2018YFC1704500]; Tianjin Committee of
   Science and Technology [18JCYBJC94700]; Tianjin Municipal Education
   Commission Reseach Project [2017KJ128]
FX National Key R&D Program of China, Grant/Award Number: 2018YFC1704500;
   Tianjin Committee of Science and Technology, Grant/Award Number:
   18JCYBJC94700; Tianjin Municipal Education Commission Reseach Project,
   Grant/Award Number: 2017KJ128
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NR 30
TC 0
Z9 0
U1 1
U2 37
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0269-3879
EI 1099-0801
J9 BIOMED CHROMATOGR
JI Biomed. Chromatogr.
PD OCT
PY 2021
VL 35
IS 10
AR e5153
DI 10.1002/bmc.5153
EA MAY 2021
PG 13
WC Biochemical Research Methods; Biochemistry & Molecular Biology;
   Chemistry, Analytical; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Pharmacology & Pharmacy
GA UO4GV
UT WOS:000649969900001
PM 33931876
DA 2026-05-27
ER

PT J
AU Erst, AA
   Petruk, AA
   Erst, AS
   Krivenko, DA
   Filinova, NV
   Maltseva, SY
   Kulikovskiy, MS
   Banaev, EV
AF Erst, Anna A.
   Petruk, Anastasia A.
   Erst, Andrey S.
   Krivenko, Denis A.
   Filinova, Nadezhda V.
   Maltseva, Svetlana Y.
   Kulikovskiy, Maxim S.
   Banaev, Evgeny V.
TI Optimization of Biomass Accumulation and Production of Phenolic
   Compounds in Callus Cultures of Rhodiola rosea L. Using Design of
   Experiments
SO PLANTS-BASEL
LA English
DT Article
DE roseroot; in vitro culture; design of experiments; nitrogen source;
   plant growth regulator; methyl jasmonate; HPLC; phenolic compound;
   histochemistry
ID METHYL JASMONATE; CINNAMYL ALCOHOL; CELL-CULTURES; HAIRY-ROOTS; GROWTH;
   BIOTRANSFORMATION; SALIDROSIDE; ACID; GLYCOSIDES; AGE
AB Rhodiola rosea L. is a valuable medicinal plant with adaptogenic, neuroprotective, antitumor, cardioprotective, and antidepressant effects. In this study, design of experiments methodology was employed to analyze and optimize the interacting effects of mineral compounds (concentration of NO3- and the ratio of NH4+ to K+) and two plant growth regulators [total 6-benzylaminopurine (BAP) and alpha-naphthylacetic acid (NAA) concentration and the ratio of BAP to NAA] on the growth and the production of total phenolic compounds (TPCs) in R. rosea calluses. The overall effect of the model was highly significant (p < 0.0001), indicating that NH4+, K+, NO3-, BAP, and NAA significantly affected growth. The best callus growth (703%) and the highest production of TPCs (75.17 mg/g) were achieved at an NH4+/K+ ratio of 0.33 and BAP/NAA of 0.33, provided that the concentration of plant growth regulators was 30 mu M and that of NO3- was <= 40 mM. According to high-performance liquid chromatography analyses of aerial parts (leaves and stems), in vitro seedlings and callus cultures of R. rosea contain no detectable rosarin, rosavin, rosin, and cinnamyl alcohol. This is the first report on the creation of an experiment for the significant improvement of biomass accumulation and TPC production in callus cultures of R. rosea.
C1 [Erst, Anna A.; Petruk, Anastasia A.; Erst, Andrey S.; Banaev, Evgeny V.] Russian Acad Sci, Siberian Branch, Cent Siberian Bot Garden, Novosibirsk 630090, Russia.
   [Erst, Andrey S.] Natl Res Tomsk State Univ, Lab Plants Systemat & Phylogeny, Tomsk 634050, Russia.
   [Krivenko, Denis A.; Filinova, Nadezhda V.] Russian Acad Sci, Siberian Branch, Siberian Inst Plant Physiol & Biochem, Irkutsk 664033, Russia.
   [Maltseva, Svetlana Y.; Kulikovskiy, Maxim S.] Russian Acad Sci, KA Timiryazev Inst Plant Physiol, Moscow 127276, Russia.
C3 Russian Academy of Sciences; Siberian Branch of the Russian Academy of
   Sciences; Central Siberian Botanical Garden; Tomsk State University;
   Russian Academy of Sciences; Siberian Branch of the Russian Academy of
   Sciences; Irkutsk Science Centre of the Russian Academy of Sciences;
   Siberian Institute of Plant Physiology & Biochemistry; Sochava Institute
   of Geography, Siberian Branch of the Russian Academy of Sciences;
   Russian Academy of Sciences; Timiryazev Institute of Plant Physiology
RP Erst, AA (corresponding author), Russian Acad Sci, Siberian Branch, Cent Siberian Bot Garden, Novosibirsk 630090, Russia.
EM erst_aa@csbg-nsk.ru; pet.a@mail.ru; erst_andrew@yahoo.com;
   krivenko.irk@gmail.com; filinova_nv@mail.ru; svetadm32@gmail.com;
   max-kulikovsky@yandex.ru; alnus2005@mail.ru
RI Svetlana, Maltseva/A-9334-2017; Erst, Anna/D-4784-2015; Banaev,
   Evgeny/O-8564-2015; Erst, Andrey/M-3444-2016; /AAP-3007-2021;
   Kulikovskiy, Maxim/B-3575-2017; Krivenko, Denis/AAA-5988-2019
OI Svetlana, Maltseva/0000-0002-6060-3968; Petruk,
   Anastasia/0000-0001-6094-0422; Erst, Anna/0000-0002-1980-4100; Banaev,
   Evgeny/0000-0003-1314-8429; Erst, Andrey/0000-0002-4844-0254; Krivenko,
   Denis/0000-0003-2658-1723
FU Russian Foundation for Basic Research; Novosibirsk region
   [20-44-540005]; budgetary project of the Central Siberian Botanical
   Garden, SB RAS [AAAA-A17-117012610051-5]; Ministry of Science and Higher
   Education of the Russian Federation [121041200194-7]
FX This research was funded by the Russian Foundation for Basic Research
   and Novosibirsk region, grant number 20-44-540005, the budgetary project
   of the Central Siberian Botanical Garden, SB RAS No.
   AAAA-A17-117012610051-5 within the framework of the State Assignment and
   the Ministry of Science and Higher Education of the Russian Federation,
   theme No. 121041200194-7 (IPP RAS).
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NR 64
TC 15
Z9 18
U1 3
U2 26
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 2223-7747
J9 PLANTS-BASEL
JI Plants-Basel
PD JAN
PY 2022
VL 11
IS 1
AR 124
DI 10.3390/plants11010124
PG 17
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences
GA YF3YY
UT WOS:000741747500001
PM 35009127
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Jia, ZX
   Zou, GM
   Xie, YY
   Zhang, EN
   Yimingjiang, M
   Cheng, XL
   Fang, C
   Wei, F
AF Jia, Zhixin
   Zou, Guoming
   Xie, Yongyan
   Zhang, Enning
   Yimingjiang, Mureziya
   Cheng, Xianlong
   Fang, Cong
   Wei, Feng
TI Pharmacokinetic-Pharmacodynamic Correlation Analysis of Rhodiola
   crenulata in Rats with Myocardial Ischemia
SO PHARMACEUTICALS
LA English
DT Article
DE myocardial ischemia; pharmacokinetics; pharmacodynamics; PK-PD; Rhodiola
   crenulata
ID MS/MS METHOD; SALIDROSIDE; PHARMACOLOGY; ABSORPTION; KAEMPFEROL;
   MECHANISM; EXCRETION; PLASMA; MODEL; DRUG
AB The pharmacokinetics (PK) of Rhodiola crenulata in rats were studied, and pharmacokinetic-pharmacodynamic (PK-PD) correlation analysis was performed to elucidate their time-concentration-effect relationship. The myocardial ischemia model was made with pituitrin. Rats were divided into sham operation, sham operation administration, model, and model administration groups (SG, SDG, MG, and MDG, respectively; n = 6). Blood was collected from the fundus venous plexus at different time points after oral administration. The HPLC-QQQ-MS/MS method was established for the quantification of five components of Rhodiola crenulata. CK, HBDH, SOD, LDH, and AST at different time points were detected via an automatic biochemical analyzer. DAS software was used to analyze PK parameters and PK-PD correlation. The myocardial ischemia model was established successfully. There were significant differences in the PK parameters (AUC(0-t), AUC(0-infinity), C-max) in MDG when compared with SDG. Two PD indicators, CK and HBDH, conforming to the sigmoid-E-max model, had high correlation with the five components, which indicated a delay in the pharmacological effect relative to the drug concentration in plasma. The difference in the PK parameters between modeled and normal rats was studied, and the time-concentration-effect of composition and effect indicators were investigated. This study can provide reference for the rational clinical application of Rhodiola crenulata and for related studies of other anti-myocardial ischemia drugs.
C1 [Jia, Zhixin; Cheng, Xianlong; Wei, Feng] Natl Inst Food & Drug Control, Beijing 100050, Peoples R China.
   [Zou, Guoming; Xie, Yongyan; Fang, Cong] Jiangxi Univ Chinese Med, Nanchang 330004, Jiangx i, Peoples R China.
   [Zhang, Enning] Beijing Univ Chinese Med, Sch Life Sci, Beijing 102401, Peoples R China.
   [Yimingjiang, Mureziya] Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 102401, Peoples R China.
C3 National Institute of Food & Drug Control - China; Jiangxi University of
   Traditional Chinese Medicine; Beijing University of Chinese Medicine;
   Beijing University of Chinese Medicine
RP Cheng, XL (corresponding author), Natl Inst Food & Drug Control, Beijing 100050, Peoples R China.; Fang, C (corresponding author), Jiangxi Univ Chinese Med, Nanchang 330004, Jiangx i, Peoples R China.
EM jessiejzx@163.com; zouguoming@jxutcm.edu; lyan8227@126.com;
   18634085688@126.com; marziya96@163.com; cxl@nifdc.org.cn;
   fangcong150@126.com
RI Jia, Zhixin/GNP-4427-2022; Cong, Fang/ADE-6221-2022
OI Jia, Zhixin/0000-0003-3849-2234; Cong, Fang/0000-0002-0457-5472; 衣明江,
   木热孜亚/0009-0007-5600-435X; NIFDC, weifeng/0000-0002-7598-0723
FU Beijing Municipal Natural Science Foundation
FX No Statement Available
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NR 43
TC 2
Z9 2
U1 2
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1424-8247
J9 PHARMACEUTICALS-BASE
JI Pharmaceuticals
PD MAY
PY 2024
VL 17
IS 5
AR 595
DI 10.3390/ph17050595
PG 16
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA SH8H9
UT WOS:001233651300001
PM 38794164
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Jung, H
   Oh, J
   Kwon, Y
   Kang, W
   Seo, M
   Seol, Y
   Park, JW
AF Jung, Hogwuan
   Oh, JaeWook
   Kwon, Younghae
   Kang, Woongshin
   Seo, Minsuk
   Seol, Yurin
   Park, Je Won
TI Enzymatic Biosynthesis of Simple Phenolic Glycosides as Potential
   Anti-Melanogenic Antioxidants
SO ANTIOXIDANTS
LA English
DT Article
DE simple phenolic glycosides; glycosyltransferase; StSPGT;
   4-hydroxyphenyl-2-propanoyl-O-alpha-glucoside; anti-melanogenic
   antioxidants; elastase inhibitor
ID BIOLOGICAL-ACTIVITY; ALPHA-ARBUTIN; OLIVE OIL; DERIVATIVES; SALIDROSIDE;
   ALCOHOL; TYROSOL; CELLS
AB Simple phenolics (SPs) and their glycosides have recently gained much attention as functional skin-care resources for their anti-melanogenic and antioxidant activities. Enzymatic glycosylation of SP aglycone make it feasible to create SP glycosides with updated bioactive potentials. Herein, a glycosyltransferase (GT)-encoding gene was cloned from the fosmid libraries of Streptomyces tenjimariensis ATCC 31603 using GT-specific degenerate PCR followed by in silico analyses. The recombinant StSPGT was able to flexibly catalyze the transfer of two glycosyl moieties towards two SP acceptors, (hydroxyphenyl-2-propanol [HPP2] and hydroxyphenyl-3-propanol [HPP3]), generating stereospecific alpha-anomeric glycosides as follows: HPP2-O-alpha-glucoside, HPP2-O-alpha-2 ''-deoxyglucoside, HPP3-O-alpha-glucoside and HPP3-0-alpha-2 ''-deoxyglucoside. This enzyme seems not only to prefer UDP-glucose and HPP2 as a favorable glycosyl donor and acceptor, respectively but also differentiates the positional difference of the hydroxyl function as acceptor catalytic sites. Paired in vitro and in vivo antioxidant assays represented SPs and their corresponding glycosides as convincing antioxidants in a time- and concentration-dependent manner by scavenging DPPH radicals and intracellular ROS. Even compared to the conventional agents, HPP2 and glycoside analogs displayed improved tyrosinase inhibitory activity in vitro and still suppressed in vivo melanogenesis. Both HPP2 glycosides are further likely to exert the best inhibitory activity against elastase, eventually highlighting these glycosides with enhanced anti-melanogenic and antioxidant activities as promising anti-wrinkle hits.
C1 [Jung, Hogwuan; Oh, JaeWook; Kwon, Younghae; Kang, Woongshin; Seo, Minsuk; Seol, Yurin] Korea Univ, Dept Integrated Biomed & Life Sci, Transdisciplinary Major Learning Hlth Syst, Seoul 02841, South Korea.
   [Park, Je Won] Korea Univ, Sch Biosyst & Biomed Sci, Seoul 02841, South Korea.
   [Park, Je Won] Korea Univ, Dept Integrated Biomed & Life Sci, Seoul 02841, South Korea.
C3 Korea University; Korea University; Korea University
RP Park, JW (corresponding author), Korea Univ, Sch Biosyst & Biomed Sci, Seoul 02841, South Korea.; Park, JW (corresponding author), Korea Univ, Dept Integrated Biomed & Life Sci, Seoul 02841, South Korea.
EM dkslejtmzm@korea.ac.kr; wook369@korea.ac.kr; rnjsdudgo21@korea.ac.kr;
   dnd4730@korea.ac.kr; panda7894@korea.ac.kr; dlscjsdbfls@korea.ac.kr;
   jewonpark@korea.ac.kr
RI Seol, Yurin/HCH-9115-2022
OI Park, Je Won/0000-0001-9460-2296
FU National Research Foundation of Korea (NRF) - Ministry of Science and
   ICT [2020R1A2C2008061]
FX This work was supported by the National Research Foundation of Korea
   (NRF). Grants funded by the Ministry of Science and ICT
   (2020R1A2C2008061).
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NR 35
TC 4
Z9 4
U1 0
U2 28
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JUL
PY 2022
VL 11
IS 7
AR 1396
DI 10.3390/antiox11071396
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 3J4DP
UT WOS:000833347400001
PM 35883887
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhang, MM
   Tang, ZY
AF Zhang, Mingming
   Tang, Zhiyin
TI Therapeutic potential of natural molecules against Alzheimer?s disease
   via SIRT1 modulation
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Review
DE Alzheimer?s disease; Natural molecules; Phytochemicals; SIRT1;
   Pharmacological mechanism
ID NF-KAPPA-B; PHYTIC ACID; COGNITIVE IMPAIRMENT; OXIDATIVE STRESS;
   CLINICAL-TRIAL; MOUSE MODEL; INDUCED NEUROTOXICITY; CALORIC RESTRICTION;
   OLEUROPEIN AGLYCONE; DOUBLE-BLIND
AB Alzheimer's disease (AD) is a neurodegenerative disease mainly characterized by progressive cognitive dysfunction and memory impairment. Recent studies have shown that regulating silent information regulator 1 (SIRT1) expression has a significant neuroprotective effect, and SIRT1 may become a new therapeutic target for AD. Natural molecules are an important source of drug development for use in AD therapy and may regulate a wide range of biological events by regulating SIRT1 as well as other SIRT1-mediated signaling pathways. This review aims to summarize the correlation between SIRT1 and AD and to identify in vivo and in vitro studies investigating the anti-AD properties of natural molecules as modulators of SIRT1 and SIRT1-mediated signaling pathways. A literature search was conducted for studies published between January 2000 and October 2022 using various literature databases, including Web of Science, PubMed, Google Scholar, Science Direct, and EMBASE. Natural molecules, such as resveratrol, quercetin, icariin, bisdemethoxycurcumin, dihydromyricetin, salidroside, patchouli, sesamin, rhein, ligustilide, tetramethoxyflavanone, 1-theanine, schisandrin, curcumin, betaine, pterostilbene, ampelopsin, schisanhenol, and eriodictyol, have the potential to modulate SIRT1 and SIRT1 signaling pathways, thereby combating AD. The natural molecules modulating SIRT1 discussed in this review provide a potentially novel multi-mechanistic therapeutic strategy for AD. However, future clinical trials need to be conducted to further investigate their beneficial properties and to determine the safety and efficacy of SIRT1 natural activators against AD.
C1 [Zhang, Mingming] China Med Univ, Dept Pathol, Shengjing Hosp, Shenyang, Liaoning, Peoples R China.
   [Tang, Zhiyin] China Med Univ, Dept Anesthesiol, Shengjing Hosp, Shenyang, Liaoning, Peoples R China.
   [Tang, Zhiyin] China Med Univ, Dept Anesthesiol, Shengjing Hosp, 36 Sanhao St, Shenyang 110000, Liaoning, Peoples R China.
   [Zhang, Mingming] China Med Univ, Dept Pathol, Shengjing Hosp, 36 Sanhao St, Shenyang 110000, Liaoning, Peoples R China.
C3 China Medical University; China Medical University; China Medical
   University; China Medical University
RP Tang, ZY (corresponding author), China Med Univ, Dept Anesthesiol, Shengjing Hosp, 36 Sanhao St, Shenyang 110000, Liaoning, Peoples R China.
EM 20072251@cum.edu.cn; tangzy@sj-hospital.org
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NR 260
TC 53
Z9 57
U1 3
U2 46
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD MAY
PY 2023
VL 161
AR 114474
DI 10.1016/j.biopha.2023.114474
EA MAR 2023
PG 20
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA E0OC2
UT WOS:000972621800001
PM 36878051
OA gold
DA 2026-05-27
ER

PT J
AU Shi, XY
   He, YX
   Ge, MY
   Liu, P
   Zheng, P
   Li, ZH
AF Shi, Xiao-yu
   He, Yi-xi
   Ge, Man-yue
   Liu, Peng
   Zheng, Ping
   Li, Zheng-hao
TI Gastrodin promotes CNS myelinogenesis and alleviates demyelinating
   injury by activating the PI3K/AKT/mTOR signaling
SO ACTA PHARMACOLOGICA SINICA
LA English
DT Article
DE demyelinating diseases; myelinogenesis; oligodendrocyte; gastrodin;
   PI3K/AKT/mTOR; Zebrafish
ID SCHWANN-CELLS; REMYELINATION; MYELINATION; OLIGODENDROCYTES; MECHANISMS;
   ZEBRAFISH; POLARIZATION; PROTECTS
AB Demyelination is a common feature of numerous neurological disorders including multiple sclerosis and leukodystrophies. Although myelin can be regenerated spontaneously following injury, this process is often inadequate, potentially resulting in neurodegeneration and exacerbating neurological dysfunction. Several drugs aimed at promoting the differentiation of oligodendrocyte precursor cells (OPCs) have yielded unsatisfactory clinical effects. A recent study has shifted the strategy of pro-OPC differentiation towards enhancing myelinogenesis. In this study we identified the pro-myelinating drug using a zebrafish model. Five traditional Chinese medicine monomers including gastrodin, paeoniflorin, puerarin, salidroside and scutellarin were assessed by bath-application in Tg (MBP:eGFP-CAAX) transgenic line at 1-5 dpf. Among the 5 monomers, only gastrodin exhibited significant pro-myelination activity. We showed that gastrodin (10 mu M) enhanced myelin sheath formation and oligodendrocyte (OL) maturation without affecting the number of OLs. Gastrodin markedly increased the phosphorylation levels of PI3K, AKT, and mTOR in primary cultured OLs via direct interaction with PI3K. Co-treatment with the PI3K inhibitor LY294002 (5 mu M) mitigated gastrodin-induced OL maturation. Furthermore, injection of gastrodin (100 mg<middle dot>kg-1<middle dot>d-1, i.p.) effectively facilitated remyelination in a lysophosphatidylcholine-induced demyelinating mouse model and alleviated demyelination in the experimental autoimmune encephalomyelitis mice. These results identify gastrodin as a promising therapeutic agent for demyelinating diseases and highlight the potential of the zebrafish model for screening pro-myelinogenic pharmacotherapy.
C1 [Shi, Xiao-yu; He, Yi-xi; Zheng, Ping] Fudan Univ, Inst Brain Sci, State Key Lab Med Neurobiol, Shanghai 200030, Peoples R China.
   [Shi, Xiao-yu; He, Yi-xi; Zheng, Ping] Fudan Univ, Inst Brain Sci, MOE, Frontiers Ctr Brain Sci, Shanghai 200030, Peoples R China.
   [He, Yi-xi] Fudan Univ, Zhongshan Hosp, Dept Neurol, Shanghai 200030, Peoples R China.
   [Ge, Man-yue; Liu, Peng; Li, Zheng-hao] Naval Med Univ, Inst Neurosci, MOE,Key Lab Mol Neurobiol, Minist Educ, Shanghai 200433, Peoples R China.
C3 Fudan University; Fudan University; Fudan University; Naval Medical
   University
RP Zheng, P (corresponding author), Fudan Univ, Inst Brain Sci, State Key Lab Med Neurobiol, Shanghai 200030, Peoples R China.; Zheng, P (corresponding author), Fudan Univ, Inst Brain Sci, MOE, Frontiers Ctr Brain Sci, Shanghai 200030, Peoples R China.; Liu, P; Li, ZH (corresponding author), Naval Med Univ, Inst Neurosci, MOE,Key Lab Mol Neurobiol, Minist Educ, Shanghai 200433, Peoples R China.
EM wuyuechaoge@163.com; pzheng@shmu.edu.cn; lzh9451@163.com
RI Li, Zhenghao/MNQ-0689-2025
OI Li, Zhenghao/0009-0005-2989-6714
FU National Natural Science Foundation of China [32100798, 82401564];
   Ministry of Science and Technology of China [2022ZD0204700]; Foundation
   of Naval Medical University [2023QN010]; Yizhang Talent Programme of
   Basic Medical College, Naval Medical University [JCYZRC-D-009]
FX This work was supported by the National Natural Science Foundation of
   China (32100798 and 82401564), the Ministry of Science and Technology of
   China STI2030-Major Projects (2022ZD0204700), Foundation of Naval
   Medical University (2023QN010), and Yizhang Talent Programme of Basic
   Medical College, Naval Medical University (JCYZRC-D-009).
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NR 79
TC 6
Z9 6
U1 5
U2 18
PU NATURE PUBL GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1671-4083
EI 1745-7254
J9 ACTA PHARMACOL SIN
JI Acta Pharmacol. Sin.
PD JUN
PY 2025
VL 46
IS 6
BP 1610
EP 1623
DI 10.1038/s41401-025-01492-z
EA FEB 2025
PG 14
WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Pharmacology & Pharmacy
GA 3IO6D
UT WOS:001432416600001
PM 40011630
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Lee, J
   Choi, HK
   Shin, HS
   Kim, GD
AF Lee, Jangho
   Choi, Hyo-Kyoung
   Shin, Hee Soon
   Kim, Gun-Dong
TI Naturally derived bioactive compounds as regulators of oxidative stress
   and inflammation in asthma
SO CHINESE MEDICINE
LA English
DT Review
DE Asthma; Allergic respiratory disease; Oxidative stress; Reactive oxygen
   species; Inflammation
ID ALLERGIC AIRWAY INFLAMMATION; NF-KAPPA-B; INNATE LYMPHOID-CELLS;
   VITAMIN-E ISOFORMS; ACUTE LUNG INJURY; MOLECULAR-MECHANISMS; SIGNALING
   PATHWAYS; ALDOSE REDUCTASE; MAST-CELL; SYNTHETIC SALIDROSIDE
AB Asthma is a chronic allergic respiratory disease characterized by symptoms such as coughing, dyspnea, and reversible airway obstruction. The incidence of asthma has been gradually increasing worldwide. However, the pathophysiological mechanisms underlying its development remain unclear due to its multifactorial etiology, which encompasses genetic, environmental, and occupational factors. Furthermore, the clinical manifestations of asthma vary significantly among individuals and across age groups, often coexisting with symptoms of atopic dermatitis and allergic rhinitis, thereby necessitating a personalized and continuous therapeutic approach. Asthma management primarily involves the use of symptom relievers and anti-inflammatory controllers, including beta(2)-agonists, anticholinergics, and corticosteroids. However, prolonged or high-dose administration of these agents poses a risk of adverse effects. Given these limitations, the development of novel asthma therapies with enhanced efficacy and fewer side effects requires a deeper understanding of the pathophysiological mechanisms underlying the development of the disease. Existing evidence from various preclinical studies suggests that oxidative stress and inflammatory responses play pivotal roles in the onset and exacerbation of asthma. Therefore, the purpose of this review was to address the multifaceted pathological mechanisms of asthma, highlight naturally derived bioactive compounds with potential antioxidative and anti-inflammatory properties that could be beneficial for asthma management. Additionally, propose an integrative therapeutic strategy that enhances patient adherence while minimizing adverse effects, ultimately contributing to improved long-term management and treatment of asthma.
C1 [Lee, Jangho; Choi, Hyo-Kyoung; Shin, Hee Soon; Kim, Gun-Dong] Korea Food Res Inst KFRI, Div Food Funct Res, Wanju 55365, South Korea.
   [Shin, Hee Soon] Korea Univ Sci & Technol UST, Dept Food Biotechnol, Daejeon 34113, South Korea.
C3 University of Science & Technology (UST)
RP Kim, GD (corresponding author), Korea Food Res Inst KFRI, Div Food Funct Res, Wanju 55365, South Korea.
EM jhlee@kfri.re.kr; chkyoung@kfri.re.kr; hsshin@kfri.re.kr; kgd@kfri.re.kr
OI Kim, Gundong/0000-0001-8518-5267
FU Main Research Program of the Korea Food Research Institute (KFRI) -
   Korean Ministry of Science and ICT [E0210400]; Korea Innovation
   Foundation - Ministry of Science and ICT [2023-DD-UP-0031]
FX This review was supported by the Main Research Program (E0210400) of the
   Korea Food Research Institute (KFRI), funded by the Korean Ministry of
   Science and ICT, and was supported by the 'Regional Innovation Mega
   Project' program (2023-DD-UP-0031) through the Korea Innovation
   Foundation, funded by the Ministry of Science and ICT.
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NR 250
TC 8
Z9 8
U1 5
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-8546
J9 CHIN MED-UK
JI Chin. Med.
PD JUL 1
PY 2025
VL 20
IS 1
AR 94
DI 10.1186/s13020-025-01142-w
PG 30
WC Integrative & Complementary Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; Pharmacology & Pharmacy
GA 4LV8C
UT WOS:001521099600002
PM 40598285
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Kumari, S
   Dhapola, R
   Sharma, P
   Paidlewar, M
   Vellingiri, B
   Medhi, B
   HarikrishnaReddy, D
AF Kumari, Sneha
   Dhapola, Rishika
   Sharma, Prajjwal
   Paidlewar, Mohit
   Vellingiri, Balachandar
   Medhi, Bikash
   HarikrishnaReddy, Dibbanti
TI Unravelling neuronal death mechanisms: The role of cytokines and
   chemokines in immune imbalance in Alzheimer's disease progression
SO AGEING RESEARCH REVIEWS
LA English
DT Review
DE Alzheimer's disease; Neuronal Cell death; Neuroinflammation; Cytokines;
   Apoptosis; PANoptosis; Oxidative stress
ID AMYLOID-BETA PEPTIDE; DECREASED PLASMA; MOUSE MODEL; ACTIVATION;
   NEUROINFLAMMATION; EXPRESSION; PATHWAY; NECROPTOSIS; PATHOLOGY;
   NEURODEGENERATION
AB Alzheimer's disease (AD) is marked by neuroinflammation, neurodegeneration and cognitive decline, with emerging evidence highlighting the critical roles of cytokines and chemokines in its pathogenesis. Regulated cell death is a highly structured and meticulously coordinated series of molecular and signalling processes involving gene expression and protein activity. This mechanism is essential for normal developmental processes and the preservation of tissue homeostasis. Abnormal regulation of inflammatory mediators contributes to or results from amyloid-(3 and tangle deposition, triggers oxidative stress, excitotoxicity, and neuroinflammation, leads to cell death through multiple mechanisms, including apoptosis, ferroptosis, pyroptosis, PANoptosis, etc. The pathogenetic mechanisms responsible for neuronal death and dysfunction in AD are not yet fully understood. This review seeks to compile evidence for the various modes of neuronal cell death in AD and to explore how the neuroinflammatory environment of the AD brain influences these distinct forms of cell death. Several inflammatory signalling cascades are involved in above discussed neuronal death mechanisms, such as RAGE/NF-kappa B, NLRP3 inflammasome, AMPK/mTOR/ULK1, cGAS-STING, RIPK1/RIPK3/MLKL, GPX4/Nrf2 and JAK-STAT pathways. Therapeutic drugs such as Magnolol, Necrostatin-1, Salidroside, Azeliragon, DNL788, Baricitinib, Sargramostim, etc. targeting neuroinflammation-associated signaling pathways, have shown efficacy in preclinical and clinical studies mitigating AD pathology. Enhancing our comprehension of neuronal death mechanisms could elucidate disease pathogenesis, offer insights for therapeutic approaches, and aid in developing modified animal models of AD.
C1 [Kumari, Sneha; Dhapola, Rishika; Sharma, Prajjwal; Paidlewar, Mohit; HarikrishnaReddy, Dibbanti] Cent Univ Punjab, Sch Hlth Sci, Dept Pharmacol, Adv Pharmacol & Neurosci Lab, Bathinda 151401, Punjab, India.
   [Vellingiri, Balachandar] Cent Univ Punjab, Sch Basic Sci, Dept Zool, Human Cytogenet & Stem Cell Lab, Bathinda 151401, Punjab, India.
   [Medhi, Bikash] Post Grad Inst Med Educ & Res, Dept Pharmacol, Chandigarh 160012, India.
C3 Central University of Punjab; Central University of Punjab; Post
   Graduate Institute of Medical Education & Research (PGIMER), Chandigarh
RP HarikrishnaReddy, D (corresponding author), Cent Univ Punjab, Acad & Adm Comm, Curriculum Design & Dev Comm, Dept Pharmacol,Adv Pharmacol & Neurosci Lab, Bathinda 151401, India.
EM harikrishnareddy0011@gmail.com
RI Vellingiri, Balachandar/MDT-9619-2025
OI HariKrishnaReddy, Dibbanti/0000-0003-2616-0195
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NR 169
TC 14
Z9 15
U1 6
U2 10
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 1568-1637
EI 1872-9649
J9 AGEING RES REV
JI Ageing Res. Rev.
PD DEC
PY 2025
VL 112
AR 102883
DI 10.1016/j.arr.2025.102883
EA AUG 2025
PG 17
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA 6XH4B
UT WOS:001564224200001
PM 40885312
DA 2026-05-27
ER

PT J
AU Wang, CY
   Gao, HB
   Cai, EB
   Zhang, LX
   Zheng, XM
   Zhang, SB
   Sun, N
   Zhao, Y
AF Wang, Chunyun
   Gao, Hongbo
   Cai, Enbo
   Zhang, Lianxue
   Zheng, Xiaoman
   Zhang, Shengbo
   Sun, Nian
   Zhao, Yan
TI Protective effects of Acanthopanax senticosus - Ligustrum
   lucidum combination on bone marrow suppression induced by
   chemotherapy in mice
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Cyclophosphamide; Myelosuppression; Acanthopanax senticosus; Ligustrum
   lucidum
AB This study investigated the combination effects of the Acanthopanax senticosus - Ligustrum lucidum (AS-LL) herb pair on bone marrow suppression caused by chemotherapy. A bone marrow suppression model was established by intraperitoneal injection (i.p.) of cyclophosphamide (CTX, 100 mg/kg). The changes in chemical composition between the AS-LL decocted together and single were analyzed, and their effects on the bone marrow nucleated cells, peripheral blood, thymus and spleen indices, in vitro hematopoietic cell culture, ELISA and cell cycle were detected. The results showed that the contents of the main active components, such as salidroside, isofraxidin and specnuezhenide in the sample of AS-LL decocted together, increased significantly compared to singles. Moreover, AS-LL decocted together exhibited a significantly better therapeutic effect on myelosuppression induced by CTX than AS and LL alone. AS-LL decocted together significantly increased the number of bone marrow nucleated cells and displayed a good regulatory effect on peripheral blood (p < 0.01), while significantly increased the thymus index (p < 0.01) and decreased the spleen index (p < 0.01). AS-LL significantly promoted the formation of cell colonies (p < 0.05), the proliferation and differentiation of hematopoietic progenitor cells, and played a positive regulatory role in hematopoietic factors. AS-LL also reduced the proportion of G0/G1 cells, increased the ratio of S and G2/M cells, and increased the cell proliferation index (PI). All these results implied that AS-LL decocted together might be a promising food additives and therapeutic agent for myelosuppression induced by chemotherapy.
C1 [Wang, Chunyun; Cai, Enbo; Zhang, Lianxue; Zheng, Xiaoman; Zhang, Shengbo; Sun, Nian; Zhao, Yan] Jilin Agr Univ, Coll Chinese Med Mat, 2888 Xincheng St, Changchun 130118, Jilin, Peoples R China.
   [Gao, Hongbo] Jilin Prov Acad Tradit Chinese Med, Clin Hosp 1, Changchun 130021, Jilin, Peoples R China.
C3 Jilin Agricultural University
RP Cai, EB; Zhao, Y (corresponding author), Jilin Agr Univ, Coll Chinese Med Mat, 2888 Xincheng St, Changchun 130118, Jilin, Peoples R China.
EM caienbo126621@126.com; zhaoyan@jlau.edu.cn
RI 张, 圣波/HLP-4630-2023; zhang, lianxue/LFU-9386-2024; Zhao,
   Yan/KHU-0655-2024
OI Zhao, Yan/0000-0003-0704-7410
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NR 25
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Z9 24
U1 1
U2 31
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD JAN
PY 2019
VL 109
BP 2062
EP 2069
DI 10.1016/j.biopha.2018.11.071
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA HD5AE
UT WOS:000452539100224
PM 30551462
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Jose, C
   Amra, K
   Bhavsar, C
   Momin, M
   Omri, A
AF Jose, Cyril
   Amra, Kesrin
   Bhavsar, Chintan
   Momin, Munira
   Omri, Abdelwahab
TI Polymeric Lipid Hybrid Nanoparticles: Properties and Therapeutic
   Applications
SO CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS
LA English
DT Review
DE polymeric lipid hybrid; nanobins; nanoparticles; lipomers
ID MEMBRANE-CAMOUFLAGED NANOPARTICLES; DRUG-DELIVERY; CO-DELIVERY;
   IN-VITRO; SALIDROSIDE PROTECTS; TRIGGERED RELEASE; CAGED NANOBINS; H9C2
   CELLS; DOXORUBICIN; SHELL
AB Some of the criteria for selection of a viable nanocarrier formulation currently being explored are the development of a site-specific and bioavailable formulation. Although the literature reports a variety of techniques for fabrication of nanocarrier systems, their stability and scale-up issues are a concern for their prominence in the pharmaceutical industry. The other widely recognized drawbacks of nanoparticulates, i.e., polymeric nanoparticles and lipid vesicular nanoparticles (liposomes), are low circulatory half-lives due to reticuloendothelial system (RES) uptake and leaky architecture leading to burst kinetics. Polymeric lipid hybrid nanoparticles (PLHNs) or lipomers are the recent advancement in nanodrug delivery systems composed of a polymeric core and lipid shell which imparts physicochemical stability and biocompatibility to the nanoparticles. The lipomers are a blend of positive attributes of both liposomes and polymeric nanoparticles wherein their individual innate flaws are negated. An extensive study of PLHN was engineered using single/two or multiple methods carried out for encapsulation efficiency, physicochemical properties, and stability. The influence of shape and composition of PLHN has also shown promising results in terms of reticuloendothelial uptake. These PLHNs have shown to hold a promising place in designing drug delivery systems for the treatment of cancer and infectious diseases as well as for theranostic purposes. The present review article encompasses various types of PLHNs, their physicochemical characteristics, and their applications as future perspectives in strategizing drug delivery to their desired sites of action.
C1 [Jose, Cyril; Amra, Kesrin; Bhavsar, Chintan; Momin, Munira] Dr Bhanuben Nanavati Coll Pharm, Bombay 400056, Maharashtra, India.
   [Omri, Abdelwahab] Laurentian Univ, Novel Drug & Vaccine Delivery Syst Facil, Dept Chem & Biochem, Sudbury, ON, Canada.
C3 Laurentian University
RP Momin, M (corresponding author), SVKMs Dr Bhanuben Nanavati Coll Pharm, Dept Pharmaceut, Bombay 400056, Maharashtra, India.
EM munira_momin@yahoo.com
RI Bhavsar, Chintan/W-8465-2018; Momin, Munira/X-2726-2018; Omri,
   Abdelwahab/G-3172-2010
OI Bhavsar, Chintan/0000-0002-7571-4812; Momin, Munira/0000-0001-5908-2627;
   Amra, Kesrin/0000-0003-3732-1126; 
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NR 77
TC 41
Z9 45
U1 0
U2 50
PU BEGELL HOUSE INC
PI DANBURY
PA 50 NORTH ST, DANBURY, CT 06810 USA
SN 0743-4863
EI 2162-660X
J9 CRIT REV THER DRUG
JI Crit. Rev. Ther. Drug Carr. Syst.
PY 2018
VL 35
IS 6
BP 555
EP 588
DI 10.1615/CritRevTherDrugCarrierSyst.2018024751
PG 34
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GT7ZH
UT WOS:000444751100003
PM 30317969
DA 2026-05-27
ER

PT J
AU Hien, TTT
   Quang, TH
   Nhiem, NX
   Tai, BH
   Yen, PH
   Yen, DTH
   Ngan, NTT
   Kim, YC
   Oh, H
   Minh, CV
   Kiem, PV
AF Truong Thi Thu Hien
   Tran Hong Quang
   Nguyen Xuan Nhiem
   Bui Huu Tai
   Pham Hai Yen
   Duong Thi Hai Yen
   Nguyen Thi Thanh Ngan
   Kim, Youn-Chul
   Oh, Hyuncheol
   Chau Van Minh
   Phan Van Kiem
TI Bioactive Secondary Metabolites from the Aerial Parts of Buddleja
   macrostachya
SO NATURAL PRODUCT COMMUNICATIONS
LA English
DT Article
DE Buddleja macrostachya; Buddlejaceae; Iridoid; Buddlemacroside A
ID PHENYLPROPANOID GLYCOSIDES; DAVIDII; LEAVES; PROLIFERATION;
   CONSTITUENTS; OFFICINALIS; GLUCOSIDES; FLAVONOIDS; SAPONINS; JAPONICA
AB A new iridoid glycoside, buddlemacroside A (1) and 15 known compounds, including 6-alpha-L-(4 ''-O-trans-p-coumaroyl)rhamnopyranosylcatalpol (2), 6-alpha-L-(2 ''-caffeoyl)rharrmopyranosylcatalpol (3), salidroside (4), echipuroside A (5), darendoside A (6), decaffeoylacteoside (7), acteoside (8), martynoside (9), 8-hydroxylinalool 3-O-beta-D-glucopyranoside (10), 9-O-alpha-L-rhamnopyranosyl-4-hydroxy-cinnamic acid (11), apigenin (12), acacetin-7-O-alpha-L-rhamnopyranosyl- (1 -> 6)-beta-D-glucopyranoside (13), mimengoside C (14), buddlejasaponin Ia (15), and buddejasaponin I (16) were isolated from a methanol extract of the aerial parts of Buddleja macrostachya Benth. Their chemical structures were elucidated by extensive spectroscopic analyses, including MS and NMR spectra as well as by comparison with the data reported in the literature. 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging test showed that compounds 3 and 7-9 possess significant scavenging capacity, with SC50 values ranging from 6.9-19.6 mu M. Compound 8 was shown to have potent inhibitory effect against the release of malondialdehyde (MDA) - the major product of the cellular lipid peroxidation, with IC50 value of 2.3 mu M. Compounds 12 and 16 significantly inhibited nitrite production in LPS-stimulated BV2 microglia, with IC50 values of 14.2 and 11.4 mu M, respectively. Furthermore, compound 16 showed cytotoxicity toward three human cancer cell lines, including SK-LU-1, MCF7, HepG2, with IC50 values in the range of 6.5-8.0 mu M.
C1 [Truong Thi Thu Hien] Vietnam Mil Med Univ, 160 Phung Hung, Phuc La, Ha Dong, Vietnam.
   [Tran Hong Quang; Nguyen Xuan Nhiem; Bui Huu Tai; Pham Hai Yen; Duong Thi Hai Yen; Chau Van Minh; Phan Van Kiem] VAST, Inst Marine Biochem, 18 Hoang Quoc Viet, Hanoi, Vietnam.
   [Nguyen Thi Thanh Ngan] VAST, Inst Genome Res, 18 Hoang Quoc Viet, Hanoi, Vietnam.
   [Kim, Youn-Chul] Wonkwang Univ, Coll Pharm, Iksan 54538, South Korea.
C3 Vietnam Academy of Science & Technology (VAST); Vietnam Academy of
   Science & Technology (VAST); Wonkwang University
RP Kiem, PV (corresponding author), VAST, Inst Marine Biochem, 18 Hoang Quoc Viet, Hanoi, Vietnam.
EM phankiem@yahoo.com
RI Oh, Hyuncheol/OON-4956-2025; Tai, Bui/S-1021-2017
FU Vietnam National Foundation for Science and Technology Development
   (NAFOSTED) [104.01-2015.66]
FX This research was supported by Vietnam National Foundation for Science
   and Technology Development (NAFOSTED) under grant number 104.01-2015.66.
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NR 30
TC 7
Z9 8
U1 0
U2 8
PU NATURAL PRODUCTS INC
PI WESTERVILLE
PA 7963 ANDERSON PARK LN, WESTERVILLE, OH 43081 USA
SN 1934-578X
EI 1555-9475
J9 NAT PROD COMMUN
JI Nat. Prod. Commun.
PD DEC
PY 2017
VL 12
IS 12
BP 1821
EP 1824
PG 4
WC Chemistry, Medicinal; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology
GA FS4HV
UT WOS:000419750600001
DA 2026-05-27
ER

PT J
AU Xu, X
   Li, PP
   Zhang, P
   Chu, M
   Liu, HJ
   Chen, XP
   Ge, Q
AF Xu, Xi
   Li, Pingping
   Zhang, Peng
   Chu, Ming
   Liu, Hongju
   Chen, Xiaoping
   Ge, Qing
TI Differential effects of Rhodiola rosea on regulatory T cell
   differentiation and interferon-γ production in vitro and in
   vivo
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE Rhodiola rosea; regulatory T cells; interferon-gamma; microgravity;
   hypoxia-inducible factor 1 alpha
ID IMBRICATA RHIZOME; AQUEOUS EXTRACT; IMMUNE-RESPONSES; SPACEFLIGHT;
   SALIDROSIDE; DURATION; EXPRESSION; OVALBUMIN; PATHWAY; L.
AB Rhodiola rosea (R. rosea), a type of adaptogen, has been previously reported to exhibit immunostimulating activity in rodents and in human peripheral blood mononuclear cells (PBMCs) in vitro. To examine the effect of R. rosea on T cells under simulated microgravity, spaceflight analogs of human head-down bed rest (HDBR) at -6 degrees and murine hind limb unloading (HU) were used. A decrease in the levels of interferon-gamma (IFN-gamma) and interleukin-17 (IL-17) and an increase in regulatory T (Treg) cells were observed in the placebo group following HDBR. The R. rosea treated HBDR group demonstrated further decreased IFN-gamma production, however, R. rosea exhibited no effect on the ratio of circulating Tregs or Treg cell differentiation. By contrast, the treatment of R. rosea on human T cells in vitro did not alter IFN-gamma secretion, however, Treg differentiation was significantly reduced. An R. rosea-induced upregulation of hypoxia-inducible factor 1 alpha (HIF-1 alpha) contributed to the suppression of Treg differentiation in vitro. Differences in the effect of R. rosea in vitro and in vivo were also observed using a mouse model of microgravity. The results of the current study suggest that R. rosea has differential modulatory effects on T cells in vivo and in vitro and care should be taken when evaluating the effects of R. rosea on the immune system.
C1 [Xu, Xi; Li, Pingping; Chu, Ming; Ge, Qing] Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Key Lab Med Immunol,Minist Hlth,Dept Immunol, 38 Xue Yuan Rd, Beijing 100191, Peoples R China.
   [Zhang, Peng; Liu, Hongju; Chen, Xiaoping] Chinese Astronaut Res & Training Ctr, State Key Lab Space Med Fundamentals & Applicat, 28 Beiqing Rd, Beijing 100094, Peoples R China.
C3 Peking University
RP Ge, Q (corresponding author), Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Key Lab Med Immunol,Minist Hlth,Dept Immunol, 38 Xue Yuan Rd, Beijing 100191, Peoples R China.; Chen, XP (corresponding author), Chinese Astronaut Res & Training Ctr, State Key Lab Space Med Fundamentals & Applicat, 28 Beiqing Rd, Beijing 100094, Peoples R China.
EM xpchen2009@yahoo.com; qingge@bjmu.edu.cn
RI Ge, Qing/HJG-9192-2022; Li, pingping/JPW-9278-2023
FU Natural Basic Research Program of China [2011CB711000]; National Natural
   Science Foundation of China [31270935, 81471525, 31171144, 81272177];
   Beijing Natural Science Foundation [5152010]; Opening Foundation of the
   State Key Laboratory of Space Medicine Fundamentals and Application,
   China Astronaut Research and Training Center [SMFA12K08]
FX The current work was supported by grants from the Natural Basic Research
   Program of China (2011CB711000), the National Natural Science Foundation
   of China (31270935 and 81471525, Q.G.; 31171144 and 81272177, X.C.),
   Beijing Natural Science Foundation (5152010, Q.G.) and the Opening
   Foundation of the State Key Laboratory of Space Medicine Fundamentals
   and Application, China Astronaut Research and Training Center
   (SMFA12K08).
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NR 32
TC 4
Z9 9
U1 0
U2 21
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD JUL
PY 2016
VL 14
IS 1
BP 529
EP 536
DI 10.3892/mmr.2016.5278
PG 8
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA DQ9TH
UT WOS:000379551700070
PM 27176566
OA Bronze
DA 2026-05-27
ER

PT J
AU Ioset, KN
   Nyberg, NT
   Van Diermen, D
   Malnoe, P
   Hostettmann, K
   Shikov, AN
   Jaroszewski, JW
AF Ioset, Karine Ndjoko
   Nyberg, Nils T.
   Van Diermen, Daphne
   Malnoe, Pia
   Hostettmann, Kurt
   Shikov, Alexander N.
   Jaroszewski, Jerzy W.
TI Metabolic Profiling of Rhodiola rosea Rhizomes by 1H
   NMR Spectroscopy
SO PHYTOCHEMICAL ANALYSIS
LA English
DT Article
DE metabolomics; NMR spectroscopy; herbal medicine; metabolic profiling;
   multivariate analysis; high-resolution loadings
ID MULTIVARIATE DATA; L.; EXTRACTS
AB Introduction - Rhodiola rosea is a broadly used medicinal plant with largely unexplored natural variability in secondary metabolite levels.
   Objective - The aim of this work was to develop a non-target procedure for H-1 NMR spectroscopic fingerprinting of rhizome extracts for pattern recognition analysis and identification of secondary metabolites responsible for differences in sample composition. To achieve this, plants from three different geographic areas (Swiss Alps, Finland, and Altai region in Siberia) were investigated.
   Results - A sample preparation procedure was developed in order to remove polymeric polyphenols as the H-1 NMR analysis of low-molecular-weight metabolites was hampered by the presence of tannins. Principal component analysis disclosed tight clustering of samples according to population. PCA models based on the aromatic region of the spectra showed that the first two components reflected changes in the content of salidroside and rosavin, respectively, the rosavin content being negatively correlated to that of rhodiocyanoside A and minor aromatics. Score plots and non-parametric variance tests demonstrated population-dependent changes according to harvest time. Data consistency was assessed using score plots and box-and-whisker graphs. In addition, a procedure for presenting loadings of PCA models based on bucketed data as high-resolution plots, which are reminiscent of real H-1 NMR spectra and help to identify latent biomarkers, is presented.
   Conclusion - This study demonstrated the usefulness of the established procedure for multivariate non-target H-1 NMR metabolic profiling of Rhodiola rosea. Copyright (c) 2010 John Wiley & Sons, Ltd.
C1 [Ioset, Karine Ndjoko; Nyberg, Nils T.; Jaroszewski, Jerzy W.] Univ Copenhagen, Fac Pharmaceut Sci, Dept Med Chem, DK-2100 Copenhagen, Denmark.
   [Ioset, Karine Ndjoko; Van Diermen, Daphne; Hostettmann, Kurt] Univ Geneva, Lab Pharmacognosie & Phytochim, Ecole Romande Pharm Lausanne Geneve, CH-1211 Geneva 4, Switzerland.
   [Malnoe, Pia] Ctr Rech Conthey, Stn Rech Agroscope Changins Wadenswil ACW, CH-1964 Conthey, Switzerland.
   [Shikov, Alexander N.] St Petersburg Inst Pharm, St Petersburg 195248, Russia.
C3 University of Copenhagen; University of Geneva; Swiss Federal Research
   Station Agroscope
RP Jaroszewski, JW (corresponding author), Univ Copenhagen, Fac Pharmaceut Sci, Dept Med Chem, Univ Pk 2, DK-2100 Copenhagen, Denmark.
EM jj@farma.ku.dk
RI Shikov, Alexander/B-1804-2008
OI Shikov, Alexander/0000-0003-4351-0695
FU Alfred Benzon Foundation, Copenhagen; Universite de Geneve; Bureau de
   l'Egalite des Chances; Apotekerfonden af 1991 (Copenhagen)
FX Financial support to NTN from the Alfred Benzon Foundation, Copenhagen,
   is gratefully acknowledged. Universite de Geneve, Bureau de l'Egalite
   des Chances, is thanked for a grant to KNI. Grant for purchase of NMR
   equipment used in this work was provided by 'Apotekerfonden af 1991'
   (Copenhagen). We thank Ms. Malgorzata Clausen and Ms. Birgitte Simonsen
   for technical assistance.
CR Akgul Y, 2004, FITOTERAPIA, V75, P612, DOI 10.1016/j.fitote.2004.06.002
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NR 26
TC 47
Z9 52
U1 0
U2 49
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0958-0344
EI 1099-1565
J9 PHYTOCHEM ANALYSIS
JI Phytochem. Anal.
PD MAR-APR
PY 2011
VL 22
IS 2
BP 158
EP 165
DI 10.1002/pca.1262
PG 8
WC Biochemical Research Methods; Plant Sciences; Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Plant Sciences; Chemistry
GA 727US
UT WOS:000287828900009
PM 20848394
DA 2026-05-27
ER

PT J
AU Zhang, DF
   Huang, CS
   Zhou, L
   Wang, BY
   Zhou, W
   Xia, TT
   Shen, P
   Li, S
   Gao, Y
AF Zhang, Dingfan
   Huang, Congshu
   Zhou, Lei
   Wang, Boyang
   Zhou, Wei
   Xia, Tiantian
   Shen, Pan
   Li, Shao
   Gao, Yue
TI Exploring the potential bioactive compounds group and mechanism of Ci
   Bai Capsule in treating leukopenia: a combined approach of network
   pharmacology and transcriptome evidences
SO CHINESE MEDICINE
LA English
DT Article
DE Ci Bai Capsule; Network target; Leukopenia; Transcriptomics; RNA-seq
   analysis
ID RADIATION; LYMPHOPENIA; MACROPHAGES; EXPRESSION; SPLEEN
AB BackgroundRadiation-induced leukopenia caused by low-dose exposure is frequently associated with Traditional Chinese Medicine (TCM) syndromes like "blood deficiency" and "fatigue syndrome". Ci Bai Capsule (CB) has been reported to enhance white blood cell levels; however, its mechanisms and bioactive compounds remain unclear.AimThis study aimed to identify the bioactive compounds group of CB and elucidate its potential mechanisms in radiation-induced leukopenia.MethodsSyndrome-related data were gathered from SYMMAP and CTD database. CB's target profile is predicted by DrugCIPHER. Network pharmacology approaches were employed to identify active compounds and related pathways. Experimental validation was conducted through flow cytometry, RNA-sequencing both ex vivo and in vivo models. RT-qPCR and Western blot were performed for quantitative validation of key targets.ResultsA total of 22 pathways related to cellular processes, immune responses, and signal transduction were identified. Five key bioactive compounds (kaempferol-3-glucorhamnoside, syringin, schisandrin, 3-hydroxytyrosol 3-O-glucoside and salidroside) were found to significantly modulate syndrome-related pathways. Optimal dosing of this compound combination enhanced leukocyte counts and splenic immune cell proliferation in irradiated mice. Transcriptomic analysis revealed that the compounds exert regulatory effects on PP1A, RB, CDK4/6, CDK2, and CDK1, thereby modulating downstream immune and hematopoietic markers such as MNDA, BST2, and HSPA1A.ConclusionOur findings suggest that CB mitigates radiation-induced leukopenia by enhancing immune and hematopoietic recovery, offering a promising therapeutic approach for managing radiation-related hematological disorders.
C1 [Zhang, Dingfan; Wang, Boyang; Li, Shao] Tsinghua Univ, Inst TCM X, Dept Automat, Bioinformat Div,BNRIST,MOE Key Lab Bioinformat, Beijing 100084, Peoples R China.
   [Zhou, Lei; Zhou, Wei; Shen, Pan; Gao, Yue] Beijing Inst Radiat Med, Beijing 100850, Peoples R China.
   [Gao, Yue] Chinese Peoples Liberat Army Gen Hosp, State Key Lab Kidney Dis, Beijing 100853, Peoples R China.
   [Huang, Congshu] Henan Univ Chinese Med, Coll Tradit Chinese Med, Zhengzhou 455046, Peoples R China.
   [Xia, Tiantian] Qinghai Univ, Med Coll, Xining 810016, Peoples R China.
C3 Tsinghua University; Academy of Military Medical Sciences - China;
   Chinese People's Liberation Army General Hospital; Henan University of
   Traditional Chinese Medicine; Qinghai University
RP Li, S (corresponding author), Tsinghua Univ, Inst TCM X, Dept Automat, Bioinformat Div,BNRIST,MOE Key Lab Bioinformat, Beijing 100084, Peoples R China.; Shen, P; Gao, Y (corresponding author), Beijing Inst Radiat Med, Beijing 100850, Peoples R China.; Gao, Y (corresponding author), Chinese Peoples Liberat Army Gen Hosp, State Key Lab Kidney Dis, Beijing 100853, Peoples R China.
EM spluto@foxmail.com; shaoli@mail.tsinghua.edu.cn; gaoyue@bmi.ac.cn
RI ; Zhang, Dingfan/HGA-0595-2022; Shen, Pan/KFS-4532-2024
OI Zhou, Wei/0000-0003-0435-7261; 
FU National Administration of Traditional Chinese Medicine
FX Not applicable.
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NR 80
TC 0
Z9 0
U1 7
U2 12
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-8546
J9 CHIN MED-UK
JI Chin. Med.
PD SEP 1
PY 2025
VL 20
IS 1
AR 139
DI 10.1186/s13020-025-01197-9
PG 19
WC Integrative & Complementary Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; Pharmacology & Pharmacy
GA 6WO9C
UT WOS:001563740000004
PM 40890790
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Martínez, MI
   Barba-Espin, G
   Favero, BT
   Lütken, H
AF Iraburu Martinez, Marta
   Barba-Espin, Gregorio
   Trevenzoli Favero, Bruno
   Lutken, Henrik
TI Rhizobium rhizogenes-mediated transformation of Rhodiola rosea
   leaf explants
SO BRAGANTIA
LA English
DT Article
DE Agrobacterium rhizogenes; explant survival; golden root; hairy root
   formation
ID HAIRY ROOT CULTURES; AGROBACTERIUM-RHIZOGENES; TR-DNA; PLANTS;
   BIOTRANSFORMATION; IDENTIFICATION; GROWTH; GENES
AB Rhodiola rosea L. is an endangered medicinal plant distributed in mountains and in high latitude regions. For its conservation, sustainable methods for the obtaining of its bioactive compounds must be developed. This work hypothesized that leaf, stem and rhizome explants of R. rosea from different geographical origins respond differently to inoculation with Rhizobium rhizogenes agropine strain ATCC43057. The objective was to generate R. rosea hairy roots (HRs) containing rol-genes. These HRs could be cultivated under axenic conditions for the extraction of the medical compounds rosavinoids and salidroside. Hereby, production of bioactive compounds could be improved per plant biomass. Thirteen R. rosea accessions of Alpine, Scandinavian, Nordic Gene Bank (NGB) and Russian origins were compared for their explant survival and HR formation. Significant differences were observed among plants from different geographical origins, where the NGB leaf explants exhibited up to 70% of HR formation and the Russian accessions did not exhibit HRs at all. Moreover, maintaining explants in light conditions after R. rhizogenes inoculation resulted in higher explant survival and HR formation rate (35%) when compared with explants kept in darkness (9%). Taken together, an efficient HR formation in roseroot by inoculation of R. rhizogenes following culturing in light was reported as a required step. This work represents a stepping-stone to R. rosea HR cultivation in bioreactors as well as regenerating whole plants. Hence, it is initiating a novel route towards high-throughput production of bioactive compounds as well preventing depletion of natural roseroot populations.
C1 [Iraburu Martinez, Marta; Barba-Espin, Gregorio; Trevenzoli Favero, Bruno; Lutken, Henrik] Univ Copenhagen, Fac Sci, Dept Plant & Environm Sci, Tastrup, Denmark.
   [Barba-Espin, Gregorio] Ctr Edafol & Biol Aplicada Segura, Dept Mejora Vegetal, Grp Biotecnol Frutales, Murcia, Spain.
C3 University of Copenhagen; Consejo Superior de Investigaciones
   Cientificas (CSIC); CSIC - Centro de Edafologia y Biologia Aplicada del
   Segura (CEBAS)
RP Lütken, H (corresponding author), Univ Copenhagen, Fac Sci, Dept Plant & Environm Sci, Tastrup, Denmark.
EM hlm@plen.ku.dk
RI ; Barba-Espín, Gregorio/AAE-6940-2021; Trevenzoli Favero,
   Bruno/C-5797-2016; Lütken, Henrik/F-9449-2014
OI Iraburu Martínez, Marta/0000-0003-1904-8998; Barba-Espín,
   Gregorio/0000-0001-9229-9668; Trevenzoli Favero,
   Bruno/0000-0002-7285-0093; Lütken, Henrik/0000-0003-3719-8324
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NR 44
TC 5
Z9 6
U1 1
U2 23
PU INST AGRONOMICO
PI CAMPINAS
PA CAIXA POSTAL 28, CAMPINAS, SP 00000, BRAZIL
SN 0006-8705
EI 1678-4499
J9 BRAGANTIA
JI Bragantia
PD APR-JUN
PY 2020
VL 79
IS 2
BP 213
EP 223
DI 10.1590/1678-4499.20190428
PG 11
WC Agriculture, Multidisciplinary; Geology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Geology
GA LV0QH
UT WOS:000538148300005
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Han, JH
   Fei, X
   Sun, N
   Xing, JJ
   Cai, EB
   Yang, LM
AF Han, Jiahong
   Fei, Xuan
   Sun, Nian
   Xing, Junjia
   Cai, Enbo
   Yang, Limin
TI Effect of Ligustri Lucidi Fructus on myelosuppression in mice induced by
   cytoxan
SO BIOMEDICAL CHROMATOGRAPHY
LA English
DT Article
DE cytoxan; myelosuppression; Ligustri Lucidi Fructus; chemotherapy; thymus
ID CYCLOPHOSPHAMIDE; BCL-2; CELLS; TRANSCRIPTION; TOXICITY; PATHWAY; BAX
AB In this study, we aimed to demonstrate the therapeutic effect of Ligustri Lucidi Fructus on chemotherapy-induced myelosuppression and elucidate its mechanism. A pharmacological study was conducted to investigate the mechanism of the inhibiting effects of Ligustri Lucidi Fructus on cyclophosphamide-induced bone marrow suppression in mice. HPLC was used to measure the chemical components. We demonstrated that medium and high doses of Ligustri Lucidi Fructus increased the amount of white blood cells and bone marrow nucleated cells (p < 0.05) in the cyclophosphamian-induced mouse model, and at the same time reduced granulocyte-macrophage-colony stimulating factor and thrombopoietin in the serum of myelosuppression mice (p < 0.01). Medium and high doses of Ligustri Lucidi Fructus can also adjust the thymus index and spleen index(p < 0.05). Ligustri Lucidi Fructus regulates the balance of bcl-2/bax, inhibits the expression of Caspase-3 and meanwhile stimulates the expression of mitogen-activated protein (MEK) and phospho extracellular regulated protein kinases (p-ERK) on the MAPK pathway. Five chemical constituents of Ligustri Lucidi Fructus, which may be related to myelosuppression, were analyzed. The content of specnuezhenide was 0.281%, that of ligustroflavone was 0.004%, that of salidroside was 0.094%, that of hydroxytyrosol was 0.060% and that of tyrosol was 0.069%. The effect of Ligustri Lucidi Fructus on myelosuppression after chemotherapy may be related to its multicomponent and multitarget nature. Ligustri Lucidi Fructus may be a promising potential drug for treatment after chemotherapy.
C1 [Han, Jiahong; Fei, Xuan; Sun, Nian; Xing, Junjia; Cai, Enbo; Yang, Limin] Jilin Agr Univ, Coll Chinese Med Mat, Xincheng St 2888, Changchun 130118, Jilin, Peoples R China.
C3 Jilin Agricultural University
RP Cai, EB; Yang, LM (corresponding author), Jilin Agr Univ, Coll Chinese Med Mat, Xincheng St 2888, Changchun 130118, Jilin, Peoples R China.
EM caienbo126621@126.com; sqcg126621@126.com
RI Han, Jiahong/KHU-7070-2024
FU Industrialization Research Project of Jilin Provincial Education
   Department [JJKH20220374CY]; Jilin Province Science & Technology
   Development Plan [20210101234JC]; Major science and technology projects
   in Jilin Province [20200504002YY]
FX Industrialization Research Project of Jilin Provincial Education
   Department, Grant/Award Number: JJKH20220374CY; Jilin Province Science &
   Technology Development Plan, Grant/Award Number: 20210101234JC; Major
   science and technology projects in Jilin Province, Grant/Award Number:
   20200504002YY
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NR 34
TC 8
Z9 9
U1 2
U2 23
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0269-3879
EI 1099-0801
J9 BIOMED CHROMATOGR
JI Biomed. Chromatogr.
PD JAN
PY 2023
VL 37
IS 1
DI 10.1002/bmc.5524
EA NOV 2022
PG 13
WC Biochemical Research Methods; Biochemistry & Molecular Biology;
   Chemistry, Analytical; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Pharmacology & Pharmacy
GA 7A1AD
UT WOS:000878590300001
PM 36241188
DA 2026-05-27
ER

PT J
AU Li, ZZ
   Peng, XY
   Zhu, XY
   Spanos, M
   Wu, L
AF Li, Zhizheng
   Peng, Xinyi
   Zhu, Xinyi
   Spanos, Michail
   Wu, Lan
TI Traditional Chinese Medicine Monomers Are Potential Candidate Drugs for
   Cancer-Induced Cardiac Cachexia
SO PHARMACOLOGY
LA English
DT Review
DE Traditional Chinese medicine; Monomers; Cancer-induced cardiac cachexia;
   Mechanisms; Targeting
ID NOTOGINSENOSIDE R1; MYOCARDIAL-ISCHEMIA; REPERFUSION INJURY;
   ENDOTHELIAL-CELLS; DOWN-REGULATION; HEART; GINKGOLIDE; DYSFUNCTION;
   APOPTOSIS; DELIVERY
AB Background: Cardiovascular diseases are now the second leading cause of death among cancer patients. Heart injury in patients with terminal cancer can lead to significant deterioration of left ventricular morphology and function. This specific heart condition is known as cancer-induced cardiac cachexia (CICC) and is characterized by cardiac dysfunction and wasting. However, an effective pharmacological treatment for CICC remains elusive. Summary: The development and progression of CICC are closely related to pathophysiological processes, such as protein degradation, oxidative responses, and inflammation. Traditional Chinese medicine (TCM) monomers offer unique advantages in reversing heart injury, which is the end-stage manifestation of CICC except the regular treatment. This review outlines significant findings related to the impact of eleven TCM monomers, namely Astragaloside IV, Ginsenosides Rb1, Notoginsenoside R1, Salidroside, Tanshinone II A, Astragalus polysaccharides, Salvianolate, Salvianolic acids A and B, and Ginkgolide A and B, on improving heart injury. These TCM monomers are potential therapeutic agents for CICC, each with specific mechanisms that could potentially reverse the pathological processes associated with CICC. Advanced drug delivery strategies, such as nano-delivery systems and exosome-delivery systems, are discussed as targeted administration options for the therapy of CICC. Key Message: This review summarizes the pathological mechanisms of CICC and explores the pharmacological treatment of TCM monomers that promote anti-inflammation, antioxidation, and pro-survival. It also considers pharmaceutical strategies for administering TCM monomers, highlighting their potential as therapies for CICC.
C1 [Li, Zhizheng; Peng, Xinyi; Zhu, Xinyi; Wu, Lan] Shanghai Univ Med & Hlth Sci, Zhoupu Hosp, Shanghai Key Lab Mol Imaging, Shanghai, Peoples R China.
   [Li, Zhizheng] Shanghai Univ Med & Hlth Sci, Sch Med Technol, Shanghai, Peoples R China.
   [Peng, Xinyi] Shanghai Univ Med & Hlth Sci, Sch Pharm, Shanghai, Peoples R China.
   [Zhu, Xinyi] Shanghai Univ Med & Hlth Sci, Sch Clin Med Sci, Shanghai, Peoples R China.
   [Spanos, Michail] Massachusetts Gen Hosp, Cardiovasc Div, Boston, MA USA.
   [Spanos, Michail] Harvard Med Sch, Boston, MA USA.
   [Wu, Lan] Shanghai Univ Med & Hlth Sci, Sch Basic Med Sci, Shanghai, Peoples R China.
C3 Shanghai University of Medicine & Health Sciences; Shanghai University
   of Medicine & Health Sciences; Shanghai University of Medicine & Health
   Sciences; Shanghai University of Medicine & Health Sciences; Harvard
   University; Harvard University Medical Affiliates; Massachusetts General
   Hospital; Harvard University; Harvard Medical School; Shanghai
   University of Medicine & Health Sciences
RP Wu, L (corresponding author), Shanghai Univ Med & Hlth Sci, Zhoupu Hosp, Shanghai Key Lab Mol Imaging, Shanghai, Peoples R China.; Wu, L (corresponding author), Shanghai Univ Med & Hlth Sci, Sch Basic Med Sci, Shanghai, Peoples R China.
EM wul@sumhs.edu.cn
RI Spanos, Michail/GLR-5585-2022; Li, Zhi-Zheng/LSJ-2487-2024
OI Li, Zhi-Zheng/0009-0008-4732-5327
FU National Natural Sciences Foundation of China [82270295]; Special
   Clinical Research Project of Shanghai Municipal Health Commission
   [20204Y0378]; Construction project of high-level local universities;
   Shanghai University of Medicine and Health Sciences [E1-2601-23-201006];
   Construction project of Shanghai Key Laboratory of Molecular Imaging
   [18DZ2260400]
FX This work was supported by the National Natural Sciences Foundation of
   China (82270295), the Special Clinical Research Project of Shanghai
   Municipal Health Commission (20204Y0378),the Construction project of
   high-level local universities, the Shanghai University of Medicine and
   Health Sciences (E1-2601-23-201006), and the Construction project of
   Shanghai Key Laboratory of Molecular Imaging (18DZ2260400).
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NR 87
TC 4
Z9 5
U1 6
U2 15
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0031-7012
EI 1423-0313
J9 PHARMACOLOGY
JI Pharmacology
PD FEB
PY 2025
VL 110
IS 1
BP 49
EP 61
DI 10.1159/000540915
EA AUG 2024
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 0MD2K
UT WOS:001356231100001
PM 39250889
DA 2026-05-27
ER

PT J
AU Li, RN
   Hong, P
   Zheng, X
AF Li, Ruonan
   Hong, Pan
   Zheng, Xin
TI β-carotene attenuates lipopolysaccharide-induced inflammation via
   inhibition of the NF-κB, JAK2/STAT3 and JNK/p38 MAPK signaling pathways
   in macrophages
SO ANIMAL SCIENCE JOURNAL
LA English
DT Article
DE beta-carotene; inflammation; JAK2/STAT3; MAPK; NF-kappa B
ID TRANSDUCTION PATHWAYS; GENE-EXPRESSION; SUPPRESSION; ACTIVATION; LPS;
   CELLS; SALIDROSIDE; APOPTOSIS; RESPONSES; STRESS
AB beta-carotene is one of the most abundant carotenoids, has potential anti-inflammatory effect, it has been reported that beta-carotene could suppress LPS-induced inflammatory responses by inhibiting nuclear factor kappa B (NF-kappa B) translocation, but the more detailed molecular mechanisms underlying the anti-inflammatory action of beta-carotene remain to be fully understood. In this study, we investigated the influence of beta-carotene on the activation of JAK2/STAT3, MAPK, and NF-kappa B signaling pathway induced by LPS in RAW264.7 cells and peritoneal macrophages. Cells were treated with different concentrations of beta-carotene for 3 hr after LPS treatment for 24 hr. The mRNA expression and the release of IL-1 beta, IL-6, and TNF-alpha were evaluated by RT-PCR and ELISA, and the level of signaling proteins of JAK2/STAT3, MAPK, and NF-kappa B signaling pathway were detected by Western blot. The results showed that beta-carotene significantly suppressed (p < 0.05) LPS-induced release of IL-1 beta, IL-6, and TNF-alpha and their mRNA expression. LPS-induced JAK2/STAT3, I kappa B/NF-kappa B p65, JNK/p38 MAPK signal activation were significantly attenuated (p < 0.05) by beta-carotene in a dose-dependent manner. In conclusion, beta-carotene could attenuate LPS-induced inflammation via inhibition of the NF-kappa B, JAK2/STAT3, and JNK/p38 MAPK signaling pathways in macrophages.
C1 [Li, Ruonan; Hong, Pan; Zheng, Xin] Jilin Agr Univ, Coll Anim Sci & Technol, Changchun, Jilin, Peoples R China.
C3 Jilin Agricultural University
RP Zheng, X (corresponding author), Jilin Agr Univ, Coll Anim Sci & Technol, Changchun, Jilin, Peoples R China.
EM jilinzhengxin@126.com
OI Li, Defang/0000-0003-4151-9151
FU National Natural Science Foundation of China [31672511]
FX National Natural Science Foundation of China, Grant/Award Number:
   31672511
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NR 42
TC 71
Z9 77
U1 1
U2 48
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1344-3941
EI 1740-0929
J9 ANIM SCI J
JI Anim. Sci. J.
PD JAN
PY 2019
VL 90
IS 1
BP 140
EP 148
DI 10.1111/asj.13108
PG 9
WC Agriculture, Dairy & Animal Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture
GA HG4QP
UT WOS:000454960300017
PM 30460722
DA 2026-05-27
ER

PT J
AU Liu, YM
   Wang, XH
   Lan, YX
AF Liu, Yameng
   Wang, Xiaohu
   Lan, Yuxia
TI Label-free detection of ConA-induced T-lymphocyte activation at
   single-cell level by microfluidics
SO ELECTROPHORESIS
LA English
DT Article
DE concanavalin A; dielectrophoresis; herbal medicine; lymphocyte;
   proliferation
AB Lymphocyte activation is critical in regulating immune responses. The resulting T-cell proliferation has been implicated in the pathogenesis of a variety of autoimmune diseases, such as SLE and rheumatoid arthritis. ConA (concanavalin A)-induced activation has been widely used in the T lymphocytes model of immune-mediated liver injury, autoimmune hepatitis, and so on. In those works, it usually requires fluorescent labeling or cell staining to confirm whether the cells are transformed successfully after medicine treatment to figure out efficacy/pharmacology. The detection preparation steps are time-consuming and have limitations for further proteomic/genomic identifications. Here, a label-free microfluidic method is established to detect lymphocyte activation degree. The lymphocyte and ConA-activated lymphocyte were investigated by a microfluidic device. According to where single cells in the sample were captured in the designed channel, lymphocyte and ConA-activated samples are differentiated and characterized by population electric field factors, 2.08 x 104 and 2.21 x 104 V/m, respectively. Furthermore, salidroside, a herbal medicine that was documented to promote the transformation, was used to treat lymphocyte cells, and the treated cell population is detected to be 2.67 x 104 V/m. The characterization indicates an increasing trend with the activation degree. The result maintains a high consistency with traditional staining methods with transformed cells of 15.8%, 28.8%, and 48.3% in each cell population. Dielectrophoresis is promising to work as a tool for detecting lymphocyte transformation and medical efficacy detection.
C1 [Liu, Yameng; Lan, Yuxia] Tianjin Univ Tradit Chinese Med, Sch Chinese Mat Med, New campus Tianjin Univ Tradit Chinese Med, Tianjin 301617, Peoples R China.
   [Wang, Xiaohu] Tianjin Sinogerman Univ Appl Sci, Intelligent Mfg Coll, Tianjin, Peoples R China.
C3 Tianjin University of Traditional Chinese Medicine; Tianjin Sino-German
   University of Applied Sciences
RP Liu, YM (corresponding author), Tianjin Univ Tradit Chinese Med, Sch Chinese Mat Med, New campus Tianjin Univ Tradit Chinese Med, Tianjin 301617, Peoples R China.
EM yameng1990@126.com
RI Liu, Yameng/LGY-1586-2024
FU Tianjin Municipal Science and Technology Bureau, Tianjin Applied Basic
   Research Multiple Investment Funding [21JCQNJC01180]
FX Tianjin Municipal Science and Technology Bureau, Tianjin Applied Basic
   Research Multiple Investment Funding, Grant/Award Number: 21JCQNJC01180
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NR 27
TC 0
Z9 0
U1 8
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0173-0835
EI 1522-2683
J9 ELECTROPHORESIS
JI Electrophoresis
PD DEC
PY 2024
VL 45
IS 23-24
SI SI
BP 2125
EP 2131
DI 10.1002/elps.202400060
EA AUG 2024
PG 7
WC Biochemical Research Methods; Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA R6S6V
UT WOS:001286484900001
PM 39119740
DA 2026-05-27
ER

PT J
AU Li, DH
   Zhuo, YZ
   Zhang, Q
   Zhang, LQ
   Zhang, SK
   Lv, YS
   Li, CX
   Cui, LH
   Guan, X
   Yang, L
   Wang, XM
AF Li, Dihua
   Zhuo, Yuzhen
   Zhang, Qi
   Zhang, Lanqiu
   Zhang, Shukun
   Lv, Yuanshan
   Li, Caixia
   Cui, Lihua
   Guan, Xin
   Yang, Lei
   Wang, Ximo
TI Purification of 3, 4-dihydroxyphenylethyl alcohol glycoside from
   Sargentodoxa cuneata (Oliv.) Rehd. et Wils. and its protective
   effects against DSS-induced colitis
SO SCIENTIFIC REPORTS
LA English
DT Article
ID PHENYLETHANOID GLYCOSIDES; PREPARATIVE PURIFICATION; MACROPOROUS RESIN;
   SEPARATION; HYDROXYTYROSOL; SALIDROSIDE; GROWTH; OIL
AB Sargentodoxa cuneata is a tropical plant used in traditional Chinese medicine to treat intestinal inflammation. In this study, 3, 4-dihydroxyphenylethyl alcohol glycoside (DAG) was purified from the stem of S. cuneata using macroporous resins and its bioactivity was also investigated. The adsorption/desorption of DAG on macroporous resins was investigated systematically. HPD300 resin was selected as the most suitable medium for DAG purification. Further dynamic absorption/desorption experiments on the HPD300 column were conducted to obtain the optimal parameters. To obtain more than 95% DAG, a second stage procedure was developed to purify the DAG using SiliaSphere C18 with 8% v/v acetonitrile through elution at low pressure. Further investigation showed that DAG pretreatment significantly reversed the shortening of colon length, the increase in the disease activity index (DAI) scores and histological damage in the colon. Moreover, DAG greatly increased SOD and GPx activities, significantly decreased MPO and MDA activities and reduced the levels of pro-inflammatory cytokines in the colon. Free radical scavenging activities of DAG were assessed using DPPH, with an IC50 value of 17.03 ug/mL. Additionally, DAG suppressed ROS and proinflammatory cytokine production in LPS-stimulated RAW 264.7 macrophages by suppressing activation of the ERK1/2 and NF-kappa B pathways. The results were indicative of the antioxidant and anti-inflammatory properties of DAG. When viewed together, these findings indicated that DAG can be used to expand future pharmacological research and to potentially treat colitis.
C1 [Li, Dihua; Zhuo, Yuzhen; Zhang, Qi; Zhang, Lanqiu; Zhang, Shukun; Lv, Yuanshan; Li, Caixia; Cui, Lihua; Guan, Xin; Yang, Lei; Wang, Ximo] Tianjin Inst Acute Abdominal Dis Integrated Tradi, Tianjin 300100, Peoples R China.
   [Wang, Ximo] Tianjin Nankai Hosp, Dept Surg, Tianjin 300100, Peoples R China.
RP Yang, L; Wang, XM (corresponding author), Tianjin Inst Acute Abdominal Dis Integrated Tradi, Tianjin 300100, Peoples R China.; Wang, XM (corresponding author), Tianjin Nankai Hosp, Dept Surg, Tianjin 300100, Peoples R China.
EM nkyanglei@nankai.edu.cn; wangximonkyy@126.com
RI Yang, Lie/JXY-1497-2024
FU National Natural Science Foundation of China [81470263, 81602496];
   Science Foundation of Tianjin Municipal Health Bureau [2013KY26,
   2017035]; Tianjin Science and Technology Project, China [13RCGFSY19300]
FX The authors thank the National Natural Science Foundation of China (No.
   81470263; No. 81602496), the Science Foundation of Tianjin Municipal
   Health Bureau (2013KY26; 2017035) and the Tianjin Science and Technology
   Project, China (No. 13RCGFSY19300), for their support in financing this
   research.
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NR 28
TC 9
Z9 12
U1 1
U2 30
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAR 1
PY 2019
VL 9
AR 3222
DI 10.1038/s41598-019-38926-8
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA HN1YW
UT WOS:000459983900028
PM 30824734
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Velderrain-Rodríguez, GR
   Quero, J
   Osada, J
   Martín-Belloso, O
   Rodríguez-Yoldi, MJ
AF Velderrain-Rodriguez, Gustavo R.
   Quero, Javier
   Osada, Jesus
   Martin-Belloso, Olga
   Jesus Rodriguez-Yoldi, Maria
TI Phenolic-Rich Extracts from Avocado Fruit Residues as Functional Food
   Ingredients with Antioxidant and Antiproliferative Properties
SO BIOMOLECULES
LA English
DT Article
DE polyphenols; bioactive compounds; functional Ingredients; cancer; Caco-2
   cells; ROS; agroindustrial byproducts
ID NUTRITIONAL COMPOSITION; CHLOROGENIC ACID; BY-PRODUCTS; APOPTOSIS;
   LUTEOLIN; BIOACCESSIBILITY; METABOLISM; PROFILE; GROWTH; CELLS
AB In this study, the total phenolic compounds content and profile, the nutritional value, the antioxidant and antiproliferative activities of avocado peel, seed coat, and seed extracts were characterized. Additionally, an in-silico analysis was performed to identify the phenolic compounds with the highest intestinal absorption and Caco-2 permeability. The avocado peel extract possessed the highest content of phenolic compounds (309.95 +/- 25.33 mMol GA/100 g of extract) and the lowest effective concentration (EC50) against DPPH and ABTS radicals (72.64 +/- 10.70 and 181.68 +/- 18.47, respectively). On the other hand, the peel and seed coat extracts had the lowest energy densities (226.06 +/- 0.06 kcal/100 g and 219.62 +/- 0.49 kcal/100 g, respectively). Regarding the antiproliferative activity, the avocado peel extract (180 +/- 40 mu g/mL) showed the lowest inhibitory concentration (IC50), followed by the seed (200 +/- 21 mu g/mL) and seed coat (340 +/- 32 mu g/mL) extracts. The IC50 of the extracts induced apoptosis in Caco-2 cells at the early and late stages. According to the in-silico analysis, these results could be related to the higher Caco-2 permeability to hydroxysalidroside, salidroside, sakuranetin, and luteolin. Therefore, this study provides new insights regarding the potential use of these extracts as functional ingredients with antioxidant and antiproliferative properties and as medicinal agents in diseases related to oxidative stress such as cancer.
C1 [Velderrain-Rodriguez, Gustavo R.; Martin-Belloso, Olga] Univ Lleida, Agrotecnio Ctr, Dept Food Technol, Av Alcalde Rovira Roure 191, Lleida 25198, Spain.
   [Quero, Javier; Osada, Jesus; Jesus Rodriguez-Yoldi, Maria] Univ Zaragoza, Vet Fac, Dept Pharmacol & Physiol Forens & Legal Med, Zaragoza 50013, Spain.
   [Osada, Jesus] Univ Zaragoza, Vet Fac, Dept Biochem & Mol Cell Biol, Zaragoza 50009, Spain.
   [Osada, Jesus; Jesus Rodriguez-Yoldi, Maria] IIS Aragon, ISCIII, CIBERobn, IA2, Madrid 28029, Spain.
C3 Universitat de Lleida; University of Zaragoza; University of Zaragoza;
   CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Instituto de
   Salud Carlos III
RP Rodríguez-Yoldi, MJ (corresponding author), Univ Zaragoza, Vet Fac, Dept Pharmacol & Physiol Forens & Legal Med, Zaragoza 50013, Spain.; Rodríguez-Yoldi, MJ (corresponding author), IIS Aragon, ISCIII, CIBERobn, IA2, Madrid 28029, Spain.
EM grvelderrain@gmail.com; javierquero94@gmail.com; josada@unizar.es;
   olga.martin@udl.cat; mjrodyol@unizar.es
RI Quero, Javier/JSK-6954-2023; Velderrain Rodríguez,
   Gustavo/IQV-4959-2023; Martin-Belloso, Olga/ABA-4758-2022
OI Quero, Javier/0009-0001-5345-6947; Velderrain Rodríguez,
   Gustavo/0000-0001-5031-8402; Rodríguez Yoldi, María
   Jesús/0000-0002-3595-7668; Martin-Belloso, Olga/0000-0002-7027-6972
FU Spanish Ministry of Economy and Competitiveness; FEDER, UE
   [AGL2015-65975-R, RTI2018-094268-B-C21]; Ministry of Science and
   Technology [PID2019-104915RB-I00]; Gobierno de Aragon (Fondos FEDER
   "otra manera de hacer Europa") [B16-20R]; SUDOE (Redvalue)
   [SOE1/PI/E0123]; CIBEROBN [CB06/03/1012]
FX This work was supported by the Spanish Ministry of Economy and
   Competitiveness and FEDER, UE (grants AGL2015-65975-R and
   RTI2018-094268-B-C21) and by grants from Ministry of Science and
   Technology (PID2019-104915RB-I00), CIBEROBN (CB06/03/1012), Gobierno de
   Aragon (B16-20R, Fondos FEDER "otra manera de hacer Europa"), SUDOE
   (Redvalue, SOE1/PI/E0123).
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NR 65
TC 52
Z9 57
U1 1
U2 32
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD JUL
PY 2021
VL 11
IS 7
AR 977
DI 10.3390/biom11070977
PG 22
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA TN5QU
UT WOS:000676289600001
PM 34356601
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Ashvin
   Dhapola, R
   Kumari, S
   Sharma, P
   Vellingiri, B
   Medhi, B
   HariKrishnaReddy, D
AF Ashvin, Rishika
   Dhapola, Rishika
   Kumari, Sneha
   Sharma, Prajjwal
   Vellingiri, Balachandar
   Medhi, Bikash
   HariKrishnaReddy, Dibbanti
TI Unraveling the Immune Puzzle: Role of Immunomodulation in Alzheimer's
   Disease
SO JOURNAL OF NEUROIMMUNE PHARMACOLOGY
LA English
DT Review
DE Alzheimer's disease; Immunomodulation; Molecular pathways; Signaling
   pathways; Therapeutics
ID THERAPEUTIC STRATEGY; INNATE IMMUNITY; AMYLOID-BETA; RECEPTORS;
   GLUTAMATE; TREM2; TNF; NEUROINFLAMMATION; NEUROPROTECTION; ETANERCEPT
AB Alzheimer's disease (AD) is a complex neurodegenerative disorder with growing evidence highlighting the dual role of immunomodulation in its pathogenesis and potential therapeutic strategies. Disturbance in the immune system increases the inflammatory cytokines that cause tau hyperphosphorylation and neuroinflammation. Also, immune checkpoint inhibition further increases the amyloid-beta deposition. Therefore, this review examines the intricate interplay between the immune system and AD, focusing on how immunomodulatory mechanisms influence key pathological hallmarks, including amyloid-beta aggregation, tau hyperphosphorylation, neuroinflammation, and cholinergic dysfunction. We analyse critical signaling pathways involved in immune regulation, such as Toll-like receptor (TLR), Janus kinase/signal transducer and activator of transcription (JAK/STAT), phosphoinositide 3-kinase/Akt (PI3K/Akt), Wnt/beta-catenin, tumor necrosis factor (TNF), and triggering receptor expressed on myeloid cells (TREM), along with immune checkpoints like programmed cell death protein 1 (PD-1). Preclinical studies of immunomodulatory agents, including salidroside, festidinol, astragalin, sulforaphane, BM-MSC, simvastatin, Ab-T1, hTREM2, and XENP345, demonstrate promising effects. Additionally, clinical investigations of drugs such as simufilam, AL002, TB006, VGL101, DNL919, XPro1595, astragalus, and IBC-Ab002 underscore the therapeutic potential of targeting immune pathways in AD. This review emphasizes how neuroinflammation, microglial activation, and peripheral immune responses contribute to disease progression. By exploring immunomodulatory mechanisms, the article sheds light on potential therapeutic targets that could help mitigate AD pathology which may pave the way for novel interventions preventing neurodegeneration in AD.
C1 [Dhapola, Rishika; Kumari, Sneha; Sharma, Prajjwal; HariKrishnaReddy, Dibbanti] Cent Univ Punjab, Sch Hlth Sci, Dept Pharmacol, Adv Pharmacol & Neurosci Lab, Bathinda 151401, Punjab, India.
   [Vellingiri, Balachandar] Cent Univ Punjab, Sch Basic Sci, Dept Zool, Human Cytogenet & Stem Cell Lab, Bathinda 151401, Punjab, India.
   [Medhi, Bikash] Post Grad Inst Med Educ & Res, Dept Pharmacol, Chandigarh 160012, India.
C3 Central University of Punjab; Central University of Punjab; Post
   Graduate Institute of Medical Education & Research (PGIMER), Chandigarh
RP HariKrishnaReddy, D (corresponding author), Cent Univ Punjab, Sch Hlth Sci, Dept Pharmacol, Adv Pharmacol & Neurosci Lab, Bathinda 151401, Punjab, India.
EM harikrishnareddy0011@gmail.com
RI ; Vellingiri, Balachandar/MDT-9619-2025
OI HariKrishnaReddy, Dibbanti/0000-0003-2616-0195; 
FU UGC; Department of Science and Technology- DST-INSPIRE [IF210098]
FX A is recipient of research fellowship from UGC. R.D is recipient of
   research fellowship from the Department of Science and Technology-
   DST-INSPIRE (Reg. No. IF210098). S.K and P.S are recipients of Non-NET
   fellowship. The drawn figures were partly generated using Servier
   Medical Art, provided by Servier, licensed under a Creative Commons
   Attribution 3.0 unported license.
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NR 108
TC 8
Z9 9
U1 2
U2 7
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1557-1890
EI 1557-1904
J9 J NEUROIMMUNE PHARM
JI J. Neuroimmune Pharm.
PD APR 29
PY 2025
VL 20
IS 1
AR 47
DI 10.1007/s11481-025-10210-9
PG 16
WC Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA 2CC4V
UT WOS:001479114500001
PM 40299221
OA hybrid
DA 2026-05-27
ER

PT J
AU Liu, YT
   Han, XY
   Zhao, MY
   Liu, L
   Deng, ZX
   Zhao, Q
   Yu, Y
AF Liu, Yating
   Han, Xiaoyang
   Zhao, Mengya
   Liu, Lan
   Deng, Zixin
   Zhao, Qiu
   Yu, Yi
TI Functional characterization of polyphenol oxidase OfPPO2 supports its
   involvement in parallel biosynthetic pathways of acteoside
SO PLANT JOURNAL
LA English
DT Article
DE acteoside; parallel routes; catechol moieties; polyphenol oxidase;
   Osmanthus fragrans
ID LYSINE 2-HYDROXYISOBUTYRYLATED PROTEINS; PROVIDES INSIGHTS; ARABIDOPSIS;
   IDENTIFICATION; ACETYLATION; EXPRESSION; LANDSCAPE; DEACYLASE; REVEALS
AB Acteoside is a bioactive phenylethanoid glycoside widely distributed throughout the plant kingdom. Because of its two catechol moieties, acteoside displays a variety of beneficial activities. The biosynthetic pathway of acteoside has been largely elucidated, but the assembly logic of two catechol moieties in acteoside remains unclear. Here, we identified a novel polyphenol oxidase OfPPO2 from Osmanthus fragrans, which could hydroxylate various monophenolic substrates, including tyrosine, tyrosol, tyramine, 4-hydroxyphenylacetaldehyde, salidroside, and osmanthuside A, leading to the formation of corresponding catechol-containing intermediates for acteoside biosynthesis. OfPPO2 could also convert osmanthuside B into acteoside, creating catechol moieties directly via post-modification of the acteoside skeleton. The reverse transcription-quantitative polymerase chain reaction (RT-qPCR) analysis and subcellular localization assay further support the involvement of OfPPO2 in acteoside biosynthesis in planta. These findings suggest that the biosynthesis of acteoside in O. fragrans may follow "parallel routes" rather than the conventionally considered linear route. In support of this hypothesis, the glycosyltransferase OfUGT and the acyltransferase OfAT could direct the flux of diphenolic intermediates generated by OfPPO2 into acteoside. Significantly, OfPPO2 and its orthologs constitute a functionally conserved enzyme family that evolved independently from other known biosynthetic enzymes of acteoside, implying that the substrate promiscuity of this PPO family may offer acteoside-producing plants alternative ways to synthesize acteoside. Overall, this work expands our understanding of parallel pathways plants may employ to efficiently synthesize acteoside, a strategy that may contribute to plants' adaptation to environmental challenges.
C1 [Liu, Yating; Han, Xiaoyang; Liu, Lan; Deng, Zixin; Zhao, Qiu; Yu, Yi] Wuhan Univ, Zhongnan Hosp, Hubei Clin Ctr, Dept Gastroenterol, 185 East Lake Rd, Wuhan, Peoples R China.
   [Liu, Yating; Han, Xiaoyang; Liu, Lan; Deng, Zixin; Zhao, Qiu; Yu, Yi] Wuhan Univ, Sch Pharmaceut Sci, Key Lab Intestinal & Colorectal Dis, 185 East Lake Rd, Wuhan, Peoples R China.
   [Zhao, Mengya] Wuhan Univ, Zhongnan Hosp, Dept Gynecol Oncol, 185 East Lake Rd, Wuhan, Peoples R China.
   [Zhao, Mengya] Wuhan Univ, Women & Childrens Hosp, Zhongnan Hosp, 185 East Lake Rd, Wuhan, Peoples R China.
   [Yu, Yi] Guangxi Acad Sci, State Key Lab Nonfood Biomass & Enzyme Technol, Nanning 530007, Peoples R China.
C3 Wuhan University; Wuhan University; Wuhan University; Wuhan University;
   Guangxi Academy of Sciences
RP Zhao, Q; Yu, Y (corresponding author), Wuhan Univ, Zhongnan Hosp, Hubei Clin Ctr, Dept Gastroenterol, 185 East Lake Rd, Wuhan, Peoples R China.; Zhao, Q; Yu, Y (corresponding author), Wuhan Univ, Sch Pharmaceut Sci, Key Lab Intestinal & Colorectal Dis, 185 East Lake Rd, Wuhan, Peoples R China.
EM qiuzhao@whu.edu.cn; yu_yi@whu.edu.cn
RI Liu, Yating/KIC-6821-2024; Yu, Yi/M-5409-2016
OI Yu, Yi/0000-0001-8590-0574
FU National Natural Science Foundation of China; Guangxi Science and
   Technology Base and Talent Special Project [AD23026030]; National Key
   Research and Development Program of China [2018YFA0900400]; Guiding
   Funds of Central Government [ZY23055032];  [22277095]
FX This work was supported by grants to Y.Y. from Guangxi Science and
   Technology Base and Talent Special Project (AD23026030), the National
   Key Research and Development Program of China (2018YFA0900400), the
   Guiding Funds of Central Government for Supporting the Development of
   the Local Science and Technology (ZY23055032), and National Natural
   Science Foundation of China (22277095). We thank Home for Researchers
   editorial team () for language editing service. The numerical
   calculations in this paper have been done on the supercomputing system
   in the Supercomputing Center of Wuhan University.
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NR 55
TC 5
Z9 6
U1 4
U2 35
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0960-7412
EI 1365-313X
J9 PLANT J
JI Plant J.
PD JUL
PY 2024
VL 119
IS 2
BP 927
EP 941
DI 10.1111/tpj.16807
EA JUN 2024
PG 15
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences
GA YV7Q3
UT WOS:001247242500001
PM 38872484
OA Bronze
DA 2026-05-27
ER

PT J
AU Serrano, N
   Ling, Y
   Bahieldin, A
   Mahfouz, MM
AF Serrano, Natalia
   Ling, Yu
   Bahieldin, Ahmed
   Mahfouz, Magdy M.
TI Thermopriming reprograms metabolic homeostasis to confer heat tolerance
SO SCIENTIFIC REPORTS
LA English
DT Article
ID ACQUIRED THERMOTOLERANCE; TEMPERATURE-STRESS; OXIDATIVE STRESS;
   GENE-EXPRESSION; ARABIDOPSIS; PLANT; MEMBRANES; MUTANT; LIPIDS;
   OVEREXPRESSION
AB Heat stress threatens agriculture worldwide. Plants acquire heat stress tolerance through priming, which establishes stress memory during mild or severe transient heat stress. Such induced thermotolerance restructures metabolic networks and helps maintain metabolic homeostasis under heat stress. Here, we used an electrospray ionization mass spectrometry-based platform to explore the composition and dynamics of the metabolome of Arabidopsis thaliana under heat stress and identify metabolites involved in thermopriming. Primed plants performed better than non-primed plants under severe heat stress due to altered energy pathways and increased production of branched-chain amino acids, raffinose family oligosaccharides (RFOs), lipolysis products, and tocopherols. These metabolites serve as osmolytes, antioxidants and growth precursors to help plants recover from heat stress, while lipid metabolites help protect membranes against heat stress. The carbohydrate (e.g., sucrose and RFOs) and lipid superpathway metabolites showed the most significant increases. Under heat stress, there appears to be crosstalk between carbohydrate metabolism (i.e., the thermomemory metabolites stachyose, galactinol, and raffinose) and tyrosine metabolism towards the production of the thermomemory metabolite salidroside, a phenylethanoid glycoside. Crosstalk occurs between two glycerophospholipid pathways (the biosynthetic pathways of the thermomemory metabolite S-adenosyl-L-homocysteine and the terpenoid backbone) and the delta-tocopherol (chloroplast lipid) pathway, which favors the production of glycine betaine and other essential tocopherols, respectively, compounds which are essential for abiotic stress tolerance in plants. Therefore, metabolomic analysis can provide comprehensive insights into the metabolites involved in stress responses, which could facilitate plant breeding to maximize crop yields under adverse conditions.
C1 [Serrano, Natalia; Ling, Yu; Mahfouz, Magdy M.] King Abdullah Univ Sci & Technol, Div Biol Sci, Lab Genome Engn, Thuwal 239556900, Saudi Arabia.
   [Ling, Yu] Guangdong Ocean Univ, Coll Agron, Zhanjiang 524088, Peoples R China.
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C3 King Abdullah University of Science & Technology; Guangdong Ocean
   University; King Abdulaziz University
RP Mahfouz, MM (corresponding author), King Abdullah Univ Sci & Technol, Div Biol Sci, Lab Genome Engn, Thuwal 239556900, Saudi Arabia.
EM magdy.mahfouz@kaust.edu.sa
RI Ling, Yu/LJK-7860-2024; Mahfouz, Magdy M/O-1550-2016; Bahieldin,
   Ahmed/JMQ-0163-2023
OI Mahfouz, Magdy M/0000-0002-0616-6365; Serrano Saavea, Natalia
   Lorena/0000-0002-1110-3182; 
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PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JAN 17
PY 2019
VL 9
AR 181
DI 10.1038/s41598-018-36484-z
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA HH7ZS
UT WOS:000455951300029
PM 30655560
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Wu, JT
   Yang, GW
   Qi, CH
   Zhou, L
   Hu, JG
   Wang, MS
AF Wu, Jing-tao
   Yang, Gui-wen
   Qi, Cui-hua
   Zhou, Lei
   Hu, Jian-guo
   Wang, Mao-shan
TI ANTI-INFLAMMATORY ACTIVITY OF PLATYCODIN D ON ALCOHOL-INDUCED FATTY
   LIVER RATS VIA TLR4-MYD88-NF-κB SIGNAL PATH
SO AFRICAN JOURNAL OF TRADITIONAL COMPLEMENTARY AND ALTERNATIVE MEDICINES
LA English
DT Article
DE Platycodin D; alcoholic; fatty liver; anti-inflammation; toll-like
   receptor 4
ID LIPID-PEROXIDATION; IN-VITRO; FISH-OIL; INJURY; DISEASE; SALIDROSIDE;
   ACTIVATION; IMMUNITY; PROTEIN; CELLS
AB Background: The current study was designed to evaluate the effect of Platycodin D (PD), triterpenoid saponins extracted from the roots of Platycodon grandiflorum (PG) on alcohol-induced fatty liver (AFL) and investigate the possible mechanism.
   Methods and Materials: A rat model was set up by feeding ethanol and fish oil to experimental rats, which then were treated with PD of 10, 20, 30 mg/kg body weight/day for 4 weeks, respectively, whereafter, liver function enzymes, endotoxin of serum and liver lipid were assayed by biochemical methods, cytokines, histochemistry of hepatic tissue, the protein expression of CD14 and TLR4, the mRNA expression of MD-2, MyD 88 and TRAF-6 were assayed.
   Results: Treatment with PD on AFL rats significantly decreased the levels of serum ALT, AST and TBIL, coefficient of liver index and the hepatic tissue contents of TG, additionally and dramatically decreased serum endotoxin levels, down-regulated MD-2 and CD14 levels, as well as the mRNA expression of TLR4, MyD88 and TRAF-6, accordingly suppressed NF-kappa B p65 as well as endotoxin-mediated inflammatory factors such as TNF-alpha and IL-6.
   Conclusions: Treatment with PD effectively protects against AFL through anti-inflammatory and anti-endotoxic process, and the confirmed mechanism is that PD treatment ameliorate alcoholic-induced liver injury mainly via TLR4-MyD88-NF-kappa B signal path in AFL rat.
C1 [Wu, Jing-tao] Univ Jinan, Dept Sci & Technol, Jinan 250022, Peoples R China.
   [Qi, Cui-hua; Hu, Jian-guo; Wang, Mao-shan] Univ Jinan, Dept Food Sci & Nutr, Jinan 250022, Peoples R China.
   [Zhou, Lei] Univ Jinan, Coll Biol Sci & Technol, Jinan 250022, Peoples R China.
   [Yang, Gui-wen] Shandong Normal Univ, Coll Life Sci, Jinan 250014, Peoples R China.
C3 University of Jinan; University of Jinan; University of Jinan; Shandong
   Normal University
RP Wu, JT (corresponding author), Univ Jinan, Dept Sci & Technol, Jinan 250022, Peoples R China.
EM ost_wujt@ujn.edu.cn
FU Dr. Fund projects, University of Jinan, China [XBS 1321]
FX This work was funded by Dr. Fund projects (XBS 1321), University of
   Jinan, China.
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PU AFRICAN NETWORKS ETHNOMEDICINES
PI ILE-IFE
PA OBAFEMI AWOLOWO UNIV,CLEMENT O ADEWUNMI, DRUG RES PROD UNIT, FAC
   PHARMACY, ILE-IFE, 00000, NIGERIA
SN 0189-6016
J9 AFR J TRADIT COMPLEM
JI Afr. J. Tradit. Complement. Alt. M.
PY 2016
VL 13
IS 4
BP 176
EP 183
DI 10.21010/ajtcam.v13i4.23
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA EB3HS
UT WOS:000387255300022
PM 28852734
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Wang, XK
   Deng, T
   Zhu, HF
   Peng, J
   Liang, JX
   Zhong, SJ
   Yao, C
   Jin, GY
AF Wang, Xunkai
   Deng, Tang
   Zhu, Houfan
   Peng, Jin
   Liang, Jinxi
   Zhong, Shijie
   Yao, Chen
   Jin, Guiyun
TI Chinese Herbal Medicine in Hypoxic Pulmonary Hypertension Treatment:
   Mechanisms, Progress, and Future Directions
SO DRUG DESIGN DEVELOPMENT AND THERAPY
LA English
DT Review
DE hypoxic pulmonary hypertension; Chinese herbal medicine; antioxidant;
   mechanisms; vascular remodeling; signaling pathway
ID SMOOTH-MUSCLE-CELLS; MONOCYTE CHEMOATTRACTANT PROTEIN-1;
   ARTERIAL-HYPERTENSION; NITRIC-OXIDE; MESENCHYMAL TRANSITION; NADPH
   OXIDASE; BLOOD-FLOW; RAT MODEL; IN-VIVO; EXPRESSION
AB Hypoxic pulmonary hypertension (HPH) is a severe subtype of pulmonary hypertension(PH) characterized by chronic lung disease or prolonged hypoxia, leading to pulmonary vascular remodeling and right heart failure. Traditional Chinese Medicine (TCM) has garnered significant attention for its potential therapeutic effects on HPH due to its minimal side effects, multiple target actions, affordability, and cultural acceptance. Recent studies have highlighted the potential of TCM in inhibiting pulmonary artery smooth muscle cell proliferation, modulating inflammation, and oxidative stress. This review aims to explore the mechanisms of action of TCM in treating HPH, focusing on its ability to modulate key signaling pathways involved in pulmonary vascular remodeling, such as PI3K/Akt, Nrf2, NF-kappa B, and RhoA/ROCK. The goal is to provide a comprehensive overview of the current progress and future directions in the application of TCM for HPH treatment. TCM demonstrates significant therapeutic potential in HPH by modulating signaling pathways involved in inflammation, oxidative stress, and pulmonary vascular remodeling. Key compounds such as taxifolin glycoside, resveratrol, and salidroside have shown promising effects in inhibiting abnormal proliferation of pulmonary artery smooth muscle cells (PASMCs) and reducing oxidative stress. These mechanisms contribute to the overall efficacy of TCM in preventing and treating HPH. By modulating key signaling pathways and exerting anti-inflammatory and antioxidant effects, TCM offers a promising therapeutic approach for HPH. Further research is needed to validate the clinical efficacy and safety of TCM formulations, and to explore the underlying mechanisms through modern scientific methods. The integration of TCM with modern medicine could provide new strategies for the treatment of HPH.
C1 [Wang, Xunkai; Deng, Tang; Zhu, Houfan; Peng, Jin; Zhong, Shijie; Jin, Guiyun] Hainan Med Univ, Affiliated Hosp 1, Dept Intervent Radiol & Vasc Surg, 31 Longhua Rd, Haikou, Hainan, Peoples R China.
   [Wang, Xunkai; Zhu, Houfan; Peng, Jin; Zhong, Shijie; Jin, Guiyun] Hainan Med Univ, Affiliated Hosp 1, Dept Emergency, Haikou, Peoples R China.
   [Wang, Xunkai; Zhu, Houfan; Peng, Jin; Zhong, Shijie; Jin, Guiyun] Hainan Med Univ, Coll Emergency & Trauma, Key Lab Emergency & Trauma, Minist Educ, Haikou, Peoples R China.
   [Deng, Tang; Yao, Chen] Sun Yat sen Univ, Affiliated Hosp 1, Div Vasc Surg, 58 Zhongshan 2nd Rd, Guangzhou, Guangdong, Peoples R China.
   [Liang, Jinxi] Guangxi Med Univ, Dept Ophthalmol, Affiliated Hosp 1, Nanning 530021, Guangxi, Peoples R China.
C3 Hainan Medical University; Hainan Medical University; Hainan Medical
   University; Sun Yat Sen University; Guangxi Medical University
RP Jin, GY (corresponding author), Hainan Med Univ, Affiliated Hosp 1, Dept Intervent Radiol & Vasc Surg, 31 Longhua Rd, Haikou, Hainan, Peoples R China.; Yao, C (corresponding author), Sun Yat sen Univ, Affiliated Hosp 1, Div Vasc Surg, 58 Zhongshan 2nd Rd, Guangzhou, Guangdong, Peoples R China.
EM yaochen@mail.sysu.edu.cn; 13976609625@163.com
FU National Natural Science Foundation of China [NSFC.8246036282470511];
   Hainan Key Research and Development Social Development Project
   [ZDYF2022SHFZ293, ZDYF2024SHFZ120, ZDYF2025SHFZ050]; Natural Science
   Foundation of Hainan Province [823MS146]; Hainan Provincial Health
   Commission Scientific Research Project [22A200032]; Hainan Province
   Clinical Medical Center
FX This work was supported by the National Natural Science Foundation of
   China (NSFC.8246036282470511) ; Hainan Key Research and Development
   Social Development Project (ZDYF2022SHFZ293 ZDYF2024SHFZ120
   ZDYF2025SHFZ050) ; Natural Science Foundation of Hainan Province
   (823MS146) ; Hainan Provincial Health Commission Scientific Research
   Project (22A200032) and Hainan Province Clinical Medical Center (2021) .
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NR 200
TC 5
Z9 5
U1 7
U2 9
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1177-8881
J9 DRUG DES DEV THER
JI Drug Des. Dev. Ther.
PY 2025
VL 19
BP 8265
EP 8294
DI 10.2147/DDDT.S531109
PG 30
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 7HF1F
UT WOS:001570950000001
PM 40980416
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Chen, HT
   Chen, C
   Qin, YH
   Wang, L
   Zheng, J
   Gao, FB
AF Chen, Haotian
   Chen, Chen
   Qin, Yuhui
   Wang, Lei
   Zheng, Jie
   Gao, Fabao
TI Protective effects of epigallocatechin-3-gallate counteracting the
   chronic hypobaric hypoxia-induced myocardial injury in plain-grown rats
   at high altitude
SO CELL STRESS & CHAPERONES
LA English
DT Article
DE High altitude; Hypoxia; Myocardial injury; EGCG; Oxidative stress;
   Antioxidants
ID CHRONIC MOUNTAIN-SICKNESS; STRESS-RESPONSE; SHORT-TERM; PATHWAY;
   APOPTOSIS
AB Exposure to hypobaric hypoxia (HH) environment causes stress to the body, especially the oxygen-consuming organs. Chronic HH conditions have adverse effects on the myocardium. Thus, we conducted this experiment and aim to evaluate such adverse effects and explore the therapeutic role of epigallocatechin-3-gallate (EGCG) in rats' heart under chronic HH conditions. For that purpose, we transported rats from plain to a real HH environment at high altitude for establishing the HH model. At high altitude, animals were treated with EGCG while the salidroside was used as the positive control. General physiological data were collected, and routine blood test results were analyzed. Cardiac magnetic resonance (CMR) was examined to assess the structural and functional changes of the heart. Serum levels of cardiac enzymes and pro-inflammatory cytokines were examined. Oxidative markers in the left ventricle (LV) were detected. Additionally, ultrastructural and histopathological changes and apoptosis of the LV were assessed. Furthermore, the antioxidant stress-relevant proteins nuclear factor E2-related factor 2 (Nrf2) and the heme oxygenase-1 (HO-1) were detected. The experiment revealed that EGCG treatment decreased HH-induced elevation of cardiac enzymes and relieved mitochondrial damage of the LV. Notably, EGCG treatment significantly alleviated oxidative stress in the LV and inflammatory response in the blood. Western blot confirmed that EGCG significantly upregulated Nrf2 and HO-1. Therefore, EGCG may be considered a promising natural compound for treating the HH-induced myocardial injuries.
C1 [Chen, Haotian; Chen, Chen; Qin, Yuhui; Wang, Lei; Gao, Fabao] Sichuan Univ, West China Hosp, Dept Radiol, 37 Guoxue Rd, Chengdu 610041, Peoples R China.
   [Zheng, Jie] Washington Univ, Sch Med, Mallinckrodt Inst Radiol, St Louis, MO USA.
C3 Sichuan University; Washington University (WUSTL)
RP Gao, FB (corresponding author), Sichuan Univ, West China Hosp, Dept Radiol, 37 Guoxue Rd, Chengdu 610041, Peoples R China.
EM gaofabao@wchscu.cn
FU The authors acknowledge the Molecular Imaging Center, West China
   Hospital, Sichuan University, for providing the research platform.
FX The authors acknowledge the Molecular Imaging Center, West China
   Hospital, Sichuan University, for providing the research platform.
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NR 43
TC 6
Z9 12
U1 2
U2 16
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1355-8145
EI 1466-1268
J9 CELL STRESS CHAPERON
JI Cell Stress Chaperones
PD NOV
PY 2023
VL 28
IS 6
BP 921
EP 933
DI 10.1007/s12192-023-01386-1
EA JAN 2024
PG 13
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA QP5Q8
UT WOS:001087975600001
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Ruan, X
   Zhan, LM
   Gao, XX
   Yan, LY
   Zhang, H
   Zhu, ZY
   Wang, Q
   Jiang, DA
AF Ruan Xiao
   Zhan Li-mei
   Gao Xing-xing
   Yan Liu-ye
   Zhang Huan
   Zhu Zhi-yong
   Wang Qiang
   Jiang De-an
TI Separation and purification of flavonoid from Taxus remainder extracts
   free of taxoids using polystyrene and polyamide resin
SO JOURNAL OF SEPARATION SCIENCE
LA English
DT Article
DE Flavonoids; Macroporous resins; Polyamide resin; Preparative separation;
   Taxus wallichiana var; mairei
ID INGA-EDULIS LEAVES; ADSORPTION CHROMATOGRAPHY; LIQUID-EXTRACTION;
   OPTIMIZATION; SALIDROSIDE; POLYPHENOLS; MECHANISM; L.
AB An efficient separation process of flavonoid from Taxus wallichiana var. mairei remainder extracts free of taxoids was developed in this study. AB-8 macroporous resin and polyamide resin offered the fine adsorption capacity, and its adsorption rate at 30 degrees C fitted well to the Langmuir and Freundich isotherms. Resin dynamic adsorption and desorption experiments were conducted to optimize the separation process of total flavonoids from T. wallichiana var. mairei remainder extracts free of taxoids. The optimum parameters for adsorption by AB-8 resin were as follows: (1) the concentration of flavonoids in a sample solution of 5.61 mg/mL with a processing volume of 2 bed volume (BV) (60 mL); (2) for desorption, ethanol-water (80:20, v/v), with 6 BV as an eluent at a flow rate of 2 BV/h. After a one-run treatment with AB-8 resin, the content of flavonoids was increased 5.10-fold from 4.05 to 20.65%. The optimum parameters for adsorption by polyamide resin were as follows: processing volume of 2 BV (30 mL); for desorption, ethanol-water (70:30, v/v), with 8 BV as an eluent at a flow rate of 2 BV/h. After one-run treatment with polyamide resin, the content of total flavonoids increased from 20.65 to 65.21%. The method will provide a potential approach for large-scale separation and purification of flavonoid for its wide pharmaceutical use.
C1 [Ruan Xiao; Zhan Li-mei; Jiang De-an] Zhejiang Univ, Coll Life Sci, Hangzhou 310003, Zhejiang, Peoples R China.
   [Ruan Xiao; Zhan Li-mei; Gao Xing-xing; Yan Liu-ye; Zhang Huan; Wang Qiang] Zhejiang Univ, Ningbo Inst Technol, Ningbo 315100, Zhejiang, Peoples R China.
   [Zhu Zhi-yong] Ningbo City Coll Vocat Technol, Ningbo, Zhejiang, Peoples R China.
C3 Zhejiang University; Zhejiang University; Ningbo City College of
   Vocational Technology
RP Wang, Q (corresponding author), Zhejiang Univ, Ningbo Inst Technol, Ningbo 315100, Zhejiang, Peoples R China.
EM wangqiangsky@263.net; dajiang@zju.edu.cn
RI zhu, zhiyong/R-9498-2019
FU Nature Science Foundation of China (NSFC) [30470330, 30770334]; China
   Spark Program [2012GA701002]
FX Funding from the Nature Science Foundation of China (NSFC, Project No:
   30470330, 30770334) and China Spark Program (2012GA701002) is
   acknowledged.
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NR 37
TC 32
Z9 39
U1 2
U2 101
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 1615-9306
EI 1615-9314
J9 J SEP SCI
JI J. Sep. Sci.
PD JUN
PY 2013
VL 36
IS 12
BP 1925
EP 1934
DI 10.1002/jssc.201201189
PG 10
WC Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA 166KP
UT WOS:000320553800008
PM 23936912
DA 2026-05-27
ER

PT J
AU Zhou, JH
   Zhang, JN
   Yan, ZG
   Yuan, Q
   Lu, PJ
   Zhang, YL
   Zhang, XX
AF Zhou, Jiahui
   Zhang, Jinnan
   Yan, Zhenguo
   Yuan, Qing
   Lu, Pinjie
   Zhang, Yanlong
   Zhang, Xiaoxiao
TI Transcriptomics and Metabolomics Analyses Reveal New Insights Into Cold
   Resistance in Paeonia Veitchii
SO PHYSIOLOGIA PLANTARUM
LA English
DT Article
DE cold stress; <italic>Paeonia veitchii</italic>; polyamine metabolism;
   transcriptome analysis
ID SYSTEMIC ACQUIRED-RESISTANCE; ABIOTIC STRESS TOLERANCE; SALICYLIC-ACID;
   CHILLING TOLERANCE; RESPONSES; INDUCTION; BIOACTIVITY; ACTIVATION;
   LEAVES; L.
AB Paeonia veitchii is an important economic plant that is known for its exceptional medicinal value and for its remarkable tolerance to cold. However, the molecular mechanisms underlying its cold tolerance remain unclear. In this study, an integrated approach combining physiological analysis and multi-omics techniques was employed to investigate the metabolic pathways and molecular mechanisms involved in the cold stress response of P. veitchii. Metabolomic analysis revealed significant changes in the levels of 61 metabolites under cold stress, with prominent increases in polyamines (e.g., p-Coumaroylputrescine, +2.97-fold) and phenolic acids (e.g., Syringic acid, +3.69-fold). Transcriptomic profiling identified 22,525 DEGs, including 3852 genes enriched in cold adaptation pathways including plant hormone signaling, MAPK signaling, and glutathione metabolism. Key regulators of polyamine and phenolic acid metabolism were identified, including aldehyde dehydrogenase, arginine decarboxylase, polyamine oxidase (PAO), S-adenosylmethionine decarboxylase, and aspartate aminotransferase, with downregulation of PAO, promoting salidroside accumulation but simultaneously suppressing methylated indole-3-acetic acid. Moreover, the reduced accumulation of flavonoids may be linked to the expression of flavonoid 3 '-monooxygenase. Furthermore, it was discovered that the ETH, JA-Ile, SA, and MAPK signaling pathways play an active role in the signaling of P. veitchii roots during the response to cold stress. This study offers valuable insights into the complex regulatory mechanisms that govern the cold stress response in P. veitchii roots, thereby establishing a theoretical basis for a better understanding of its response and adaptation mechanisms to cold stress.
C1 [Zhou, Jiahui; Zhang, Jinnan; Yuan, Qing; Lu, Pinjie; Zhang, Yanlong; Zhang, Xiaoxiao] Northwest A&F Univ, Coll Landscape Architecture & Art, Yangling, Peoples R China.
   [Yan, Zhenguo] Acad Agr Planning & Engn, MARA, Beijing, Peoples R China.
C3 Northwest A&F University - China
RP Zhang, YL; Zhang, XX (corresponding author), Northwest A&F Univ, Coll Landscape Architecture & Art, Yangling, Peoples R China.
EM zhangyanlong@nwafu.edu.cn; zhangbinxiao0505@126.com
RI Zhang, Jinnan/PNF-1172-2026; Zhou, Jiahui/GWU-5937-2022
FU Postdoctoral Science Foundation of Shaanxi Province; Natural Science
   Basic Research Program of Shaanxi [2024JC-YBQN-0182]; Forestry Science
   and Technology Innovation Project of Shaanxi Province [SXLK2023-02-25];
   Key project at central government level: The ability establishment of
   sustainable use for valuable Chinese medicine resources [2060302]; 
   [2023BSHYDZZ75]
FX We gratefully acknowledge financial support from the Natural Science
   Basic Research Program of Shaanxi (2024JC-YBQN-0182), Postdoctoral
   Science Foundation of Shaanxi Province (2023BSHYDZZ75), Forestry Science
   and Technology Innovation Project of Shaanxi Province (SXLK2023-02-25),
   and Key project at central government level: The ability establishment
   of sustainable use for valuable Chinese medicine resources (2060302).
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NR 70
TC 3
Z9 3
U1 8
U2 25
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0031-9317
EI 1399-3054
J9 PHYSIOL PLANTARUM
JI Physiol. Plant.
PD JUL 7
PY 2025
VL 177
IS 4
AR e70400
DI 10.1111/ppl.70400
PG 17
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences
GA 5MX0A
UT WOS:001539471100001
PM 40621825
OA Bronze
DA 2026-05-27
ER

PT J
AU Uyeturk, U
   Terzi, EH
   Gucuk, A
   Kemahli, E
   Ozturk, H
   Tosun, M
AF Uyeturk, Ugur
   Terzi, E. Hakan
   Gucuk, Adnan
   Kemahli, Eray
   Ozturk, Hayrettin
   Tosun, Mehmet
TI Prevention of Torsion-induced Testicular Injury by Rhodiola rosea
SO UROLOGY
LA English
DT Article
ID INDUCED ISCHEMIA/REPERFUSION INJURY; ISCHEMIA-REPERFUSION INJURY;
   SPERMATIC CORD TORSION; EXTRACT SHR-5; RATS; ANTIOXIDANT; SALIDROSIDE;
   ADAPTOGEN; STRESS; CELLS
AB OBJECTIVE To evaluate the efficacy of Rhodiola rosea (R. rose) extract in terms of preventing tissue injury induced by testicular torsion and subsequent ischemia/reperfusion (I/R).
   METHODS Twenty-one Wistar albino male rats were divided into 3 groups: group 1 = control group, group 2 = I/R group, and group 3 = I/R + extract group. After 2 hours of ischemia and 4 hours of reperfusion, testes were removed and evaluated histologically by hematoxylin and eosin staining. Apoptosis in spermatogonial cells of seminiferous tubules was determined by transferase biotin-2'-deoxyuridine, 5'-triphosphate nick end labeling (TUNEL). To assess oxidative damage, serum malondialdehyde (MDA) and glutathione (GSH) levels were measured.
   RESULTS Median MDA and GSH levels were, respectively, 12 +/- 3 pmol/mL and 24.8 +/- 3.8 mu M in group 1, 38 +/- 11 pmol/mL and 10.3 +/- 1.7 mu M in group 2, and 19 +/- 5 pmol/mL and 17.6 +/- 1.3 mu M in group 3 (P <.001 and P <.001, respectively). Median MDA levels, apoptotic cell density, and histopathologic scoring were significantly lower in groups 1 and 3 compared to group 2 (P <.017 for all). Median GSH levels were higher in groups 1 and 3 compared to group 2 (P <.017).
   CONCLUSION R. rosea extract was shown to have partially preventive effects on testicular injury induced by torsion in this rat model. The mechanism by which R. rosea extract cause these effects merits further investigation. UROLOGY 82: 254.e1-254.e6, 2013. (C) 2013 Elsevier Inc.
C1 [Uyeturk, Ugur] Abant Izzet Baysal Univ, Dept Urol, TR-14280 Bolu, Turkey.
   Abant Izzet Baysal Med Fac, Dept Histol, Bolu, Turkey.
   Abant Izzet Baysal Med Fac, Dept Pediat Surg, Bolu, Turkey.
   Abant Izzet Baysal Med Fac, Dept Biochem, Bolu, Turkey.
C3 Abant Izzet Baysal University; Abant Izzet Baysal University; Abant
   Izzet Baysal University; Abant Izzet Baysal University
RP Uyeturk, U (corresponding author), Abant Izzet Baysal Univ, Dept Urol, TR-14280 Bolu, Turkey.
EM uguruyeturk@yahoo.com
RI kemahlı, eray/F-6610-2012; Ozturk, Hayrettin/ONK-3376-2025
OI kemahlı, eray/0000-0003-1698-8263; Ozturk, Hayrettin/0000-0001-5608-5742
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NR 30
TC 14
Z9 17
U1 0
U2 17
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0090-4295
EI 1527-9995
J9 UROLOGY
JI Urology
PD JUL
PY 2013
VL 82
IS 1
AR 254.e1
DI 10.1016/j.urology.2013.04.018
PG 6
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 172WK
UT WOS:000321036200069
PM 23806408
DA 2026-05-27
ER

PT J
AU Xu, H
   Du, MZ
   Shen, YT
   Yang, YM
   Ding, F
   Yu, S
AF Xu, Hui
   Du, Mingzhi
   Shen, Yuntian
   Yang, Yumin
   Ding, Fei
   Yu, Shu
TI Enhancement of O-GlcNAcylation on Mitochondrial Proteins with
   2-(4-Methoxyphenyl)ethyl-2-acetamido-2-deoxy-β-d-pyranoside, Contributes
   to the Mitochondrial Network, Cellular Bioenergetics and Stress Response
   in Neuronal Cells under Ischemic-like Conditions
SO MOLECULES
LA English
DT Article
DE 2-(4-methoxyphenyl)ethyl-2-acetamido-2-deoxy-b-D-pyranoside; cellular
   bioenergetics; mitochondrial homeostasis; O-GlcNAcylation; oxygen
   glucose deprivation/reoxygenation stress; neuroprotection
ID BETA-N-ACETYLGLUCOSAMINE; AGED MICE; YOUNG; NEUROPROTECTION;
   GLYCOSYLATION; TRANSCRIPTION; MECHANISMS; SURVIVAL; CALCIUM; GLCNAC
AB O-GlcNAcylation is a nutrient-driven post-translational modification known as a metabolic sensor that links metabolism to cellular function. Recent evidences indicate that the activation of O-GlcNAc pathway is a potential pro-survival pathway and that acute enhancement of this response is conducive to the survival of cells and tissues. 2-(4-Methoxyphenyl)ethyl-2-acetamido-2-deoxy-beta-d-pyranoside (SalA-4g), is a salidroside analogue synthesized in our laboratory by chemical structure-modification, with a phenyl ring containing a para-methoxy group and a sugar ring consisting of N-acetylglucosamine. We have previously shown that SalA-4g elevates levels of protein O-GlcNAc and improves neuronal tolerance to ischemia. However, the specific target of SalA-4g regulating O-GlcNAcylation remains unknown. To address these questions, in this study, we have focused on mitochondrial network homeostasis mediated by O-GlcNAcylation in SalA-4g's neuroprotection in primary cortical neurons under ischemic-like conditions. O-GlcNAc-modified mitochondria induced by SalA-4g demonstrated stronger neuroprotection under oxygen glucose deprivation and reoxygenation stress, including the improvement of mitochondrial homeostasis and bioenergy, and inhibition of mitochondrial apoptosis pathway. Blocking mitochondrial protein O-GlcNAcylation with OSMI-1 disrupted mitochondrial network homeostasis and antagonized the protective effects of SalA-4g. Collectively, these data demonstrate that mitochondrial homeostasis mediated by mitochondrial protein O-GlcNAcylation is critically involved in SalA-4g neuroprotection.
C1 [Xu, Hui; Du, Mingzhi; Shen, Yuntian; Yang, Yumin; Ding, Fei; Yu, Shu] Nantong Univ, NMPA Key Lab Res & Evaluat Tissue Engn Technol Pr, Coinnovat Ctr Neuroregenerat, Key Lab Neuroregenerat,Jiangsu & Minist Educ, 19 Qixiu Rd, Nantong 226001, Peoples R China.
C3 Nantong University
RP Ding, F; Yu, S (corresponding author), Nantong Univ, NMPA Key Lab Res & Evaluat Tissue Engn Technol Pr, Coinnovat Ctr Neuroregenerat, Key Lab Neuroregenerat,Jiangsu & Minist Educ, 19 Qixiu Rd, Nantong 226001, Peoples R China.
EM 13862964186@163.com; 13853204312@163.com; syt517@ntu.edu.cn;
   yangym@ntu.edu.cn; dingfei@ntu.edu.cn; yushu@ntu.edu.cn
RI ; Shen, Yuntian/GPX-9670-2022; DING, FEI/KLD-8925-2024
OI Yu, Shu/0000-0003-3771-267X; Shen, Yuntian/0000-0002-5145-4761; 
FU National Key Research and Development Program of China [2017YFA0104700];
   National Natural Science Foundation of China [81401094, 81901933];
   Natural Science Research Project of Nantong Science and Technology
   Bureau [JC2020033]; Priority Academic Program Development (PAPD) of
   Jiangsu Higher Education Institutions
FX FundingThis work was supported by the National Key Research and
   Development Program of China (Grant No. 2017YFA0104700), National
   Natural Science Foundation of China (Grant Nos. 81401094 and 81901933),
   Natural Science Research Project of Nantong Science and Technology
   Bureau (Grant No. JC2020033), and the Priority Academic Program
   Development (PAPD) of Jiangsu Higher Education Institutions.
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NR 42
TC 5
Z9 5
U1 0
U2 4
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD OCT
PY 2021
VL 26
IS 19
AR 5883
DI 10.3390/molecules26195883
PG 19
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA WV5VN
UT WOS:000717304700001
PM 34641427
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhao, J
   Zhang, JW
   Liu, Q
   Wang, YC
   Jin, YC
   Yang, YX
   Ni, C
   Zhang, L
AF Zhao, Jing
   Zhang, Jiwei
   Liu, Qian
   Wang, Yingchao
   Jin, Yecheng
   Yang, Yingxin
   Ni, Cheng
   Zhang, Ling
TI Hongjingtian injection protects against myocardial ischemia
   reperfusion-induced apoptosis by blocking ROS induced autophagic- flux
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Myocardial ischemia reperfusion injury; Hongjingtian injection; Reactive
   oxygen species; Autophagic flux; Apoptosis
ID TRADITIONAL CHINESE MEDICINE; OXYGEN SPECIES ROS; RHODIOLA-ROSEA;
   ISCHEMIA/REPERFUSION INJURY; SALIDROSIDE; CELLS; RESISTANT; STRESS; L.
AB Background: Hongjingtian injection (HJT) has been widely used in the clinic to treat coronary heart disease in China. However, the underlying mechanisms of therapies still need to be illustrated. The present study aims to determine whether HJT protects against myocardial ischemia reperfusion injury via Reactive Oxygen Species (ROS)-induced autophagic flux and apoptosis and, if so, to explore the underlying mechanisms.
   Methods: In vivo myocardial protection and autophagy regulation of HJT in myocardial ischemia reperfusion injury in C57BL/6 J and CAG-RFP-EGFP-LC3 transgenic C57BL/6 J mice were investigated. In vitro, the effects of HJT on apoptosis, autophagic flux, oxidative stress and mitochondrial function were observed in H2O2-induced H9c2 cells. In addition, apoptosis-related proteins and autophagy-related proteins were assessed to explore the underlying mechanisms.
   Results: HJT significantly decreased the infarct area and cell apoptosis after myocardial ischemia reperfusion injury in C57BL/6 J mice. Autophagic flux was reduced by HJT treatment after myocardial ischemia reperfusion injury in CAG-RFP-EGFP-LC3 transgenic C57BL/6 J mice. HJT inhibited H2O2 -induced cell apoptosis by significantly decreasing the levels of cleaved caspase 3 and increasing the Bcl-2/Bax ratio. HJT inhibited autophagic flux after H2O2 stimulation by significantly decreasing LC3-II and p-AMPK expression and increasing pmTOR. HJT inhibited ROS production and improved mitochondrial function in H2O2-induced cells by significantly increasing the mitochondrial membrane potential, intracellular ATP contents and oxygen consumption.
   Conclusion: The beneficial effects of HJT in treating myocardial ischemia reperfusion are partially due to improved mitochondrial function and regulated autophagy to inhibit cell apoptosis through the AMPK/mTOR pathway.
C1 [Zhao, Jing; Ni, Cheng] Zhejiang Univ, Sch Med, Dept Cardiol, Affiliated Hosp 2, Hangzhou 310009, Peoples R China.
   [Zhang, Ling] Zhejiang Chinese Med Univ, Coll Life Sci, Hangzhou 310053, Peoples R China.
   [Zhao, Jing] Zhejiang Univ, Sch Med, Clin Res Ctr, Affiliated Hosp 2, Hangzhou, Peoples R China.
   [Zhao, Jing] Cardiovasc Key Lab Zhejiang Prov, Hangzhou, Peoples R China.
   [Zhang, Jiwei] Shanghai Univ Tradit Chinese Med, Inst Chinese Mat Med, MOE Key Lab Standardizat Chinese Med, Shanghai, Peoples R China.
   [Liu, Qian] Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou, Peoples R China.
   [Wang, Yingchao] Zhejiang Univ, Pharmaceut Imformat Inst, Coll Pharmaceut Sci, Hangzhou, Peoples R China.
   [Jin, Yecheng; Yang, Yingxin] Zhejiang Univ, Sch Med, Dept Pharmaceut, Affiliated Sir Run Run Shaw Hosp, Hangzhou, Peoples R China.
C3 Zhejiang University; Zhejiang Chinese Medical University; Zhejiang
   University; Shanghai University of Traditional Chinese Medicine;
   Zhejiang Chinese Medical University; Zhejiang University; Zhejiang
   University
RP Ni, C (corresponding author), Zhejiang Univ, Sch Med, Dept Cardiol, Affiliated Hosp 2, Hangzhou 310009, Peoples R China.; Zhang, L (corresponding author), Zhejiang Chinese Med Univ, Coll Life Sci, Hangzhou 310053, Peoples R China.
EM cescni@zju.edu.cn; zhanglingwws@163.com
RI ; Zhao, Jing/HLW-3099-2023
OI NI, CHENG/0000-0001-6978-987X; Zhao, Jing/0000-0001-8681-3296
FU National Natural Science Foundation of China [81903830, 81573641,
   81900328, 81602033, 81703740]; Natural Science Foundation of Zhejiang
   Province [LQ18H280001, LQ15H280003]; Zhejiang Provincial Natural Science
   Foundation-Provincial Pharmaceutical Association Joint Fund/Exploratory
   Project Q [LYY18H280002]; Chinese Medicine Research Program of Zhejiang
   Province [2018ZQ014]; Scientific Foundation of Zhejiang Chinese Medical
   University [2018ZZ07, 2020ZG30]; Zhejiang Medical and Health Research
   Project (Platform Key Talents Projects) [2016RCB010]
FX This work was supported by the grants from National Natural Science
   Foundation of China (No. 81903830 for Q.L., No.81573641 for L.Z.,
   No.81900328 for C.N., No. 81602033 for J.W.Z., No.81703740 for Y.C. J) ,
   the Natural Science Foundation of Zhejiang Province (No. LQ18H280001 for
   J.Z., No.LQ15H280003 for Y.C.J) , the Zhejiang Provincial Natural
   Science Foundation-Provincial Pharmaceutical Association Joint
   Fund/Exploratory Project Q (No.LYY18H280002 for Y.X.Y) , the Chinese
   Medicine Research Program of Zhejiang Province (No.2018ZQ014 for Q.L) ,
   the Scientific Foundation of Zhejiang Chinese Medical University (Key
   Program) (No.2018ZZ07for Q.L) , the Scientific Foundation of Zhejiang
   Chinese Medical University (No. 2020ZG30 for L.Z) and Zhejiang Medical
   and Health Research Project (Platform Key Talents Projects) (No.
   2016RCB010 for Y.C.J) .
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NR 49
TC 37
Z9 42
U1 4
U2 59
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD MAR
PY 2021
VL 135
AR 111205
DI 10.1016/j.biopha.2020.111205
EA JAN 2021
PG 12
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA QR7JD
UT WOS:000625390300003
PM 33395603
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Marchev, AS
   Koycheva, IK
   Aneva, IY
   Georgiev, MI
AF Marchev, Andrey S.
   Koycheva, Ivanka K.
   Aneva, Ina Y.
   Georgiev, Milen I.
TI Authenticity and quality evaluation of different Rhodiola species
   and commercial products based on NMR-spectroscopy and HPLC
SO PHYTOCHEMICAL ANALYSIS
LA English
DT Article
DE adulteration; Golden root; HPLC; NMR; OPLS-DA
ID ROSEA L.; PHYTOCHEMICAL CHARACTERIZATION; METABOLIC DIFFERENTIATIONS;
   PHENYLPROPENOID CONTENT; CHEMICAL-CONSTITUENTS; HARVEST SEASON;
   PLANT-PART; RAT PLASMA; CRENULATA; EXTRACT
AB Introduction The main concern regarding the authenticity and quality of Rhodiola rosea L. (Sedum rosea (L.) Scop.) products is their adulteration with other Rhodiola species.
   Objective The aim of the study was the development of a reliable and practical analytical platform for quality and quantity assessment of the characteristic molecules in three Rhodiola species (R. rosea, R. kirilowii (Regel) Maxim and R. crenulata (Hook. f. & Thomson) H. Ohba), commercial products and their possible application as markers for the authentication of R. rosea based products.
   Material and Methods The major molecules were identified by one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR)-based metabolomics and quantitatively determined by high-performance liquid chromatography ultraviolet (HPLC-UV) analysis. The orthogonal projections to latent structures discriminant analysis (OPLS-DA) revealed the specific patterns in the metabolite profiles of R. rosea and R. crenulata.
   Results The coumarin crenulatin was only identified in R. crenulata and can be used as a marker to detect potential adulteration of the commercial products. Crenulatin was identified in two of the four analysed products by NMR-spectroscopy. According to the HPLC data, in less than a quarter of all products, the labelled amounts of salidroside and total rosavins were confirmed.
   Conclusions The developed analytical platform was found to be useful in the investigations of the phytochemical diversity of different Rhodiola species, the recognition of the unique metabolites between them and the identification of adulterated products. Therefore, this approach could be applied from the earliest to the latest stages of the value chain in the manufacturing of R. rosea based products.
C1 [Marchev, Andrey S.; Koycheva, Ivanka K.; Georgiev, Milen I.] Bulgarian Acad Sci, Grp Plant Cell Biotechnol & Metabol, Lab Appl Biotechnol, Stephan Angeloff Inst Microbiol, 139 Ruski Blvd, Plovdiv 4000, Bulgaria.
   [Aneva, Ina Y.] Bulgarian Acad Sci, Inst Biodivers & Ecosyst Res, Sofia, Bulgaria.
C3 Bulgarian Academy of Sciences; Stephan Angeloff Institute of
   Microbiology, Bulgarian Academy of Sciences; Bulgarian Academy of
   Sciences
RP Marchev, AS (corresponding author), Bulgarian Acad Sci, Grp Plant Cell Biotechnol & Metabol, Lab Appl Biotechnol, Stephan Angeloff Inst Microbiol, 139 Ruski Blvd, Plovdiv 4000, Bulgaria.
EM andrey.marchev@yahoo.com
RI Aneva, Ina/AAI-4487-2020; Georgiev, Milen I/P-6948-2015; Marchev,
   Andrey/PFR-2450-2026
OI Aneva, Ina/0000-0002-6476-5438; Georgiev, Milen I/0000-0001-5248-6135;
   Koycheva, Ivanka/0000-0002-0785-2308; Marchev, Aney/0000-0002-7660-683X
FU National Science Fund of Bulgaria [DM11/3]
FX National Science Fund of Bulgaria, Grant/Award Number: DM11/3
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NR 52
TC 23
Z9 27
U1 6
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0958-0344
EI 1099-1565
J9 PHYTOCHEM ANALYSIS
JI Phytochem. Anal.
PD NOV
PY 2020
VL 31
IS 6
BP 756
EP 769
DI 10.1002/pca.2940
EA APR 2020
PG 14
WC Biochemical Research Methods; Plant Sciences; Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Plant Sciences; Chemistry
GA NY8SU
UT WOS:000527096600001
PM 32311178
DA 2026-05-27
ER

PT J
AU Fu, YY
   Li, LW
   Hao, SJ
   Guan, R
   Fan, GY
   Shi, CC
   Wan, HB
   Chen, WB
   Zhang, H
   Liu, GC
   Wang, JH
   Ma, LL
   You, JL
   Ni, XM
   Yue, Z
   Xu, X
   Sun, X
   Liu, X
   Lee, SMY
AF Fu, Yuanyuan
   Li, Liangwei
   Hao, Shijie
   Guan, Rui
   Fan, Guangyi
   Shi, Chengcheng
   Wan, Haibo
   Chen, Wenbin
   Zhang, He
   Liu, Guocheng
   Wang, Jihua
   Ma, Lulin
   You, Jianling
   Ni, Xuemei
   Yue, Zhen
   Xu, Xun
   Sun, Xiao
   Liu, Xin
   Lee, Simon Ming-Yuen
TI Draft genome sequence of the Tibetan medicinal herb Rhodiola
   crenulata
SO GIGASCIENCE
LA English
DT Article
DE Rhodiola crenulata; genomics; genome assembly; annotation
ID REPBASE UPDATE; GENE; DATABASE; INTERPROSCAN; PREDICTION; TOPHAT
AB Rhodiola crenulata, a well-known medicinal Tibetan herb, is mainly grown in high-altitude regions of the Tibet, Yunnan, and Sichuan provinces in China. In the past few years, increasing numbers of studies have been published on the potential pharmacological activities of R. crenulata, strengthening our understanding into its putitive active ingredient composition, pharmacological activity, and mechanism of action. These findings also provide strong evidence supporting the important medicinal and economical value of R. crenulata. Consequently, some Rhodiola species are becoming endangered because of overexploitation and environmental destruction. However, little is known about the genetic and genomic information of any Rhodiola species. Here we report the first draft assembly of the R. crenulata genome, which was 344.5 Mb (25.7 Mb Ns), accounting for 82% of the estimated genome size, with a scaffold N50 length of 144.7 kb and a contig N50 length of 25.4 kb. The R. crenulata genome is not only highly heterozygous but also highly repetitive, with ratios of 1.12% and 66.15%, respectively, based on the k-mer analysis. Furthermore, 226.6 Mb of transposable elements were detected, of which 77.03% were long terminal repeats. In total, 31 517 protein-coding genes were identified, capturing 86.72% of expected plant genes in BUSCO. Additionally, 79.73% of protein-coding genes were functionally annotated. R. crenulata is an important medicinal plant and also a potentially interesting model species for studying the adaptability of Rhodiola species to extreme environments. The genomic sequences of R. crenulata will be useful for understanding the evolutionary mechanism of the stress resistance gene and the biosynthesis pathways of the different medicinal ingredients, for example, salidroside in R. crenulata.
C1 [Fu, Yuanyuan; Sun, Xiao] Southeast Univ, Sch Biol Sci & Med Engn, State Key Lab Bioelect, Nanjing 210096, Jiangsu, Peoples R China.
   [Fu, Yuanyuan; Li, Liangwei; Hao, Shijie; Guan, Rui; Fan, Guangyi; Shi, Chengcheng; Wan, Haibo; Chen, Wenbin; Zhang, He; Liu, Guocheng; Ni, Xuemei; Yue, Zhen; Xu, Xun; Liu, Xin] BGI Shenzhen, Shenzhen 518083, Guangdong, Peoples R China.
   [Fu, Yuanyuan; Li, Liangwei; Guan, Rui; Fan, Guangyi; Wan, Haibo; Zhang, He] BGI Qingdao, 2877 Tuanjie Rd,Sinogerman Ecopk, Qingdao 266555, Shandong, Peoples R China.
   [Fan, Guangyi; Lee, Simon Ming-Yuen] Univ Macau, State Key Lab Qual Res Chinese Med, Dama Rd, Macau, Peoples R China.
   [Fan, Guangyi; Lee, Simon Ming-Yuen] Univ Macau, Inst Chinese Med Sci, Dama Rd, Macau, Peoples R China.
   [Wang, Jihua; Ma, Lulin] Yunnan Acad Agr Sci, Natl Engn Res Ctr Ornamental Hort, Flower Res Inst, 2238 Beijing Rd, Kunming 650205, Peoples R China.
   [You, Jianling] Fudan Univ, Sch Life Sci, Inst Biodivers Sci, Key Lab Biodivers Sci & Ecol Engn,Minist Educ, Songhu Rd 2005, Shanghai 200438, Peoples R China.
C3 Southeast University - China; Beijing Genomics Institute (BGI); Beijing
   Genomics Institute (BGI); University of Macau; University of Macau;
   Chinese Academy of Sciences; Yunnan Academy of Agricultural Sciences;
   Fudan University
RP Sun, X (corresponding author), Southeast Univ, Sch Biol Sci & Med Engn, State Key Lab Bioelect, Nanjing 210096, Jiangsu, Peoples R China.; Sun, X; Liu, X; Lee, SMY (corresponding author), Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China.
EM xsun@seu.edu.cn; liuxin@genomics.cn; simonlee@umac.mo
RI ; Zhang, He/LLK-8425-2024; li, liangwei/JGM-2459-2023; Liu,
   Xin/ABJ-9485-2022; Hao, Shijie/KJM-5952-2024; Fan,
   Guangyi/GPX-7106-2022; Xu, Xun/AAI-6763-2020; lee, Simon Ming
   Yuen/NOE-8462-2025
OI SHI, Chengcheng/0000-0003-2154-5491; Zhang, He/0000-0001-9294-1403; you,
   jianling/0000-0002-0683-7915; Liu, Xin/0000-0003-3256-2940; liu,
   guocheng/0000-0002-0321-3672; Guan, Rui/0000-0003-0862-2368; Hao,
   Shijie/0000-0001-9845-3101; Fan, Guangyi/0000-0001-7365-1590; Xu,
   Xun/0000-0002-5338-5173; lee, Simon Ming Yuen/0000-0002-3966-6569
FU National High Technology Research and Development Program of China
   [2014AA10A6024]; Basic Research Program by Shenzhen Municipal Government
   [JCYJ20150831201123287]; Key Research & Development Program of Jiangsu
   Province [BE2016002-3]
FX This work was supported by the National High Technology Research and
   Development Program of China (NO. 2014AA10A6024) and Basic Research
   Program Support by the Shenzhen Municipal Government (No.
   JCYJ20150831201123287) and Key Research & Development Program of Jiangsu
   Province (BE2016002-3).
CR [Anonymous], BGISEQ 500 DEBUTS IN
   [Anonymous], GIGASCIENCE DATABASE
   [Anonymous], PROTOCOLS DRAFT GENO
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NR 34
TC 40
Z9 47
U1 9
U2 75
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2047-217X
J9 GIGASCIENCE
JI GigaScience
PD MAY 5
PY 2017
VL 6
IS 6
DI 10.1093/gigascience/gix033
PG 5
WC Biology; Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Science & Technology - Other
   Topics
GA EY6AX
UT WOS:000404065900001
PM 28475810
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Xie, R
   Zhang, H
   Wang, XZ
   Yang, XZ
   Wu, SN
   Wang, HG
   Shen, P
   Ma, TH
AF Xie, Rui
   Zhang, Hong
   Wang, Xing-zhou
   Yang, Xiao-zhong
   Wu, Shang-nong
   Wang, Hong-gang
   Shen, Peng
   Ma, Tian-heng
TI The protective effect of betulinic acid (BA) diabetic nephropathy on
   streptozotocin (STZ)-induced diabetic rats
SO FOOD & FUNCTION
LA English
DT Article
ID ACUTE LUNG INJURY; MEDIATED OXIDATIVE STRESS; IN-VITRO; INFLAMMATORY
   CYTOKINES; PATHWAY; MICE; HYPERGLYCEMIA; SALIDROSIDE; ACTIVATION; VIVO
AB The present study was designed to investigate the protective effect of betulinic acid (BA) on streptozotocin (STZ)-induced diabetic rats. The rats were intraperitoneally injected with STZ (35 mg kg(-1)). 7 days later, the animals were intragastrically administered with metformin (MET, 150 mg kg(-1)), BA (20 mg kg(-1)) or BA (40 mg kg(-1)) once daily for consecutive 30 days. The blood glucose, the contents of insulin, interleukin-6 (IL-6), interleukin-1 beta (IL-1) and tumor necrosis factor-alpha (TNF-alpha) in serum were examined. The levels of IL-6, IL-1 beta, TNF-alpha, superoxide dismutase (SOD), catalase (CAT) and malondialdehyde (MDA) in kidney tissues were measured. Moreover, the histopathological alteration and the protein expressions of the signaling pathway were detected by hematoxylin and eosin (H&E) staining and western blotting, respectively. BA significantly decreased the levels of serum insulin, IL-6, IL-1 beta, TNF-alpha and blood glucose. In addition, BA increased the activities of SOD, CAT and reduced the contents of MDA, IL-6, IL-1 beta, and TNF-alpha in kidney tissues. BA also ameliorated the histopathological condition. Furthermore, BA attenuated the phosphorylations of p-adenosine 5'-monophosphate-activated protein kinase (AMPK), nuclear factor kappaB (NF-kappa B), and an inhibitor of NF-kappa B (I kappa B alpha) and the expressions of NF-E2-related factor 2 (Nrf2) and heme oxygenase (HO)-1. These findings demonstrated that BA exhibited a protective effect on diabetic nephropathy in STZ-induced rats possibly through the AMPK/NF-kappa B/Nrf2 pathway.
C1 [Xie, Rui; Yang, Xiao-zhong; Wu, Shang-nong; Wang, Hong-gang; Shen, Peng; Ma, Tian-heng] Nanjing Med Univ, Huaian Peoples Hosp 1, Dept Gastroenterol, Huaian 223300, Jiangsu, Peoples R China.
   [Zhang, Hong; Wang, Xing-zhou] Nanjing Med Univ, Huaian Peoples Hosp 1, Dept Endocrinol, Huaian 223300, Jiangsu, Peoples R China.
C3 Nanjing Medical University; Nanjing Medical University
RP Ma, TH (corresponding author), Nanjing Med Univ, Huaian Peoples Hosp 1, Dept Gastroenterol, Huaian 223300, Jiangsu, Peoples R China.
EM matianheng25@126.com
OI Wang, Honggang/0000-0003-4761-0407; Zhang, Hong/0009-0009-1382-9831
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NR 37
TC 66
Z9 74
U1 0
U2 36
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD JAN 1
PY 2017
VL 8
IS 1
BP 299
EP 306
DI 10.1039/c6fo01601d
PG 8
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA EM5WT
UT WOS:000395385200026
PM 28009869
DA 2026-05-27
ER

PT J
AU Hua, Z
   Wang, XJ
   Qin, LL
   Zhu, KP
   Li, DY
   Zhang, XY
   Zhang, L
   Zhai, FT
AF Hua, Zhen
   Wang, Xiaojie
   Qin, Le-Le
   Zhu, Kun-Peng
   Li, De-Ye
   Zhang, Xin-Yue
   Zhang, Lei
   Zhai, Feng-Ting
TI Plant-derived natural products targeting inflammation in treatment of
   atherosclerosis
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE plant-derived natural products; inflammation; atherosclerosis;
   traditional Chinese medicine; Chinese herbal medicine
ID VASCULAR SMOOTH-MUSCLE; IIA ATTENUATES ATHEROSCLEROSIS; FOAM
   CELL-FORMATION; NF-KAPPA-B; TANSHINONE-IIA; OXIDATIVE STRESS; ALLEVIATES
   ATHEROSCLEROSIS; ENDOTHELIAL FUNCTION; INDUCED APOPTOSIS; ARTERY-DISEASE
AB Atherosclerosis (AS) is a complex and chronic inflammatory vascular disease, and it's also the pathological basis of various diseases such as coronary heart disease. Owing to their advantages such as multiple targets and rich diversity, Plant-Derived natural products with abundant resources will become an important source of anti-AS drugs. Herein, we explored the intricate association between inflammation and AS, focusing on plant-derived natural products that specifically target inflammation for the treatment of AS. This review systematically analyzes 10 plant species, focusing on 23 high-potential metabolites including Tanshinone IIA, Berberine, and Ginsenoside Rb1 et al. We found that natural products with anti-AS properties are primarily derived from plants belonging to the families Araliaceae, Umbelliferae, Fabaceae, and Lamiaceae. The chemical structures of these natural products mainly consist of flavonoids, alkaloids, saponins, and polysaccharides, among others. This suggests that natural products with different structural types can exhibit anti-AS activities, with flavonoids, alkaloids, and saponins showing greater potential. Major anti-inflammatory pathways center on NF-kappa B/NLRP3 inflammasome inhibition (e.g., Tan IIA, Salidroside), ROS scavenging (e.g., Danshensu, Rosmarinic acid), and endothelial protection (e.g., Astragaloside, Puerarin), while highlighting NLRP3 inflammasome inhibition and gut-microbiota modulation as emerging therapeutic avenues. These will actively promote the clinical application and industrial production of Plant Derived natural products, thereby developing anti AS drugs with excellent efficacy and reduced adverse reactions. We hope that this comprehensive review will provide valuable insights into the potential and pharmacological mechanisms of current natural medicines, thereby offering support for future drug discoveries.
C1 [Hua, Zhen; Zhang, Lei] Shandong Univ Tradit Chinese Med, Dept Cardiol, Affiliated Hosp, Jinan, Peoples R China.
   [Wang, Xiaojie] Shandong Univ Tradit Chinese Med, Coll Tradit Chinese Med, Jinan, Peoples R China.
   [Qin, Le-Le; Zhu, Kun-Peng; Li, De-Ye; Zhang, Xin-Yue] Shandong Univ Tradit Chinese Med, Sch Clin Med 1, Jinan, Peoples R China.
   [Zhai, Feng-Ting] Shandong Univ Tradit Chinese Med, Dept Gynaecol, Affiliated Hosp, Jinan, Peoples R China.
C3 Shandong University of Traditional Chinese Medicine; Shandong University
   of Traditional Chinese Medicine; Shandong University of Traditional
   Chinese Medicine; Shandong University of Traditional Chinese Medicine
RP Zhai, FT (corresponding author), Shandong Univ Tradit Chinese Med, Dept Gynaecol, Affiliated Hosp, Jinan, Peoples R China.
EM zft0326@163.com
RI Qin, Lele/AEH-9772-2022
FU National Natural Science Foundation of China10.13039/501100001809
   [82104796]; Youth Program of NSFC [ZR2021QH219]; Youth Program of
   Natural Science Foundation of Shandong Province [zyzx2110]; Open Fund
   for the Key Laboratory of the Ministry of Education of the People's
   Republic of China on the Theory and Application of TCM Visceral
   Diseases, Liaoning University of Traditional Chinese Medicine
FX The author(s) declare that financial support was received for the
   research and/or publication of this article. This work was supported by
   Youth Program of NSFC (82104796); Youth Program of Natural Science
   Foundation of Shandong Province (ZR2021QH219); Open Fund for the Key
   Laboratory of the Ministry of Education of the People's Republic of
   China on the Theory and Application of TCM Visceral Diseases, Liaoning
   University of Traditional Chinese Medicine (zyzx2110).
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NR 131
TC 3
Z9 3
U1 14
U2 16
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD OCT 2
PY 2025
VL 16
AR 1642183
DI 10.3389/fphar.2025.1642183
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 8PO3F
UT WOS:001594274500001
PM 41111503
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Agapouda, A
   Grimm, A
   Lejri, I
   Eckert, A
AF Agapouda, Anastasia
   Grimm, Amandine
   Lejri, Imane
   Eckert, Anne
TI RETRACTED: Rhodiola Rosea Extract Counteracts Stress in an Adaptogenic
   Response Curve Manner via Elimination of ROS and Induction of Neurite
   Outgrowth (Retracted Article)
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article; Retracted Publication
ID CENTRAL-NERVOUS-SYSTEM; OXIDATIVE STRESS; GLUCOCORTICOID-RECEPTOR;
   MITOCHONDRIAL DYSFUNCTION; MOLECULAR-MECHANISMS; OPEN-LABEL;
   SALIDROSIDE; BRAIN; EXPRESSION; CELLS
AB Background. Sustained stress with the overproduction of corticosteroids has been shown to increase reactive oxygen species (ROS) leading to an oxidative stress state. Mitochondria are the main generators of ROS and are directly and detrimentally affected by their overproduction. Neurons depend almost solely on ATP produced by mitochondria in order to satisfy their energy needs and to form synapses, while stress has been proven to alter synaptic plasticity. Emerging evidence underpins that Rhodiola rosea, an adaptogenic plant rich in polyphenols, exerts antioxidant, antistress, and neuroprotective effects. Methods. In this study, the effect of Rhodiola rosea extract (RRE) WS (R) 1375 on neuronal ROS regulation, bioenergetics, and neurite outgrowth, as well as its potential modulatory effect on the brain derived neurotrophic factor (BDNF) pathway, was evaluated in the human neuroblastoma SH-SY5Y and the murine hippocampal HT22 cell lines. Stress was induced using the corticosteroid dexamethasone. Results. RRE increased bioenergetics as well as cell viability and scavenged ROS with a similar efficacy in both cells lines and counteracted the respective corticosteroid-induced dysregulation. The effect of RRE, both under dexamethasone-stress and under normal conditions, resulted in biphasic U-shape and inverted U-shape dose response curves, a characteristic feature of adaptogenic plant extracts. Additionally, RRE treatment promoted neurite outgrowth and induced an increase in BDNF levels. Conclusion. These findings indicate that RRE may constitute a candidate for the prevention of stress-induced pathophysiological processes as well as oxidative stress. Therefore, it could be employed against stress-associated mental disorders potentially leading to the development of a condition-specific supplementation.
C1 [Agapouda, Anastasia; Grimm, Amandine; Lejri, Imane; Eckert, Anne] Univ Basel, Neurobiol Lab Brain Aging & Mental Hlth, Transfac Res Platform, Mol & Cognit Neurosci, Basel, Switzerland.
   [Agapouda, Anastasia; Grimm, Amandine; Lejri, Imane; Eckert, Anne] Psychiat Univ Clin, Basel, Switzerland.
C3 University of Basel
RP Eckert, A (corresponding author), Univ Basel, Neurobiol Lab Brain Aging & Mental Hlth, Transfac Res Platform, Mol & Cognit Neurosci, Basel, Switzerland.; Eckert, A (corresponding author), Psychiat Univ Clin, Basel, Switzerland.
EM anastasia.agapouda@upk.ch; amandine.grimm@upk.ch; imane.lejri@upk.ch;
   anne.eckert@upkbs.ch
RI Grimm, Amandine/ABE-5634-2020
OI Grimm, Amandine/0000-0003-3323-1756; LEJRI, Imane/0000-0002-5379-5412;
   Agapouda, Anastasia/0000-0002-4980-9463; Eckert,
   Anne/0000-0002-9341-3669
FU Dr. Willmar Schwabe GmbH & Co KG, Karlsruhe, Germany
FX We thank Marianne Zeller and Zarko Kulic from Dr. Willmar Schwabe GmbH &
   Co. KG, Karlsruhe, Germany, for the HPLC fingerprint and the
   quantification of analytes. We thank Professor Dr. Matthias Hamburger
   for reading our manuscript and for useful discussions. This study was
   partly funded by a principal investigator-initiated research grant
   supported by Dr. Willmar Schwabe GmbH & Co KG, Karlsruhe, Germany, with
   regard to consumables and materials supply.
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NR 76
TC 11
Z9 13
U1 0
U2 23
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD MAY 13
PY 2022
VL 2022
AR 5647599
DI 10.1155/2022/5647599
PG 19
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 1S3NT
UT WOS:000803961800002
PM 35602107
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Wang, LY
   Tao, WY
   Luo, DS
   Hu, YM
   Bei, WJ
   Guo, J
AF Wang, Laiyou
   Tao, Weiye
   Luo, Duosheng
   Hu, Yinming
   Bei, Weijian
   Guo, Jiao
TI Potential synergistic effects of Chinese herbal prescription FTZ
   components detected in blood towards hepatic lipid-modulating targets
SO COMPLEMENTARY THERAPIES IN MEDICINE
LA English
DT Article
DE Hyperlipidemia; Multi-target therapeutics; Molecular docking; Virtual
   screening; Polypharmacology
ID CORONARY-HEART-DISEASE; ESTER TRANSFER PROTEIN; HMG-COA REDUCTASE;
   CARDIOVASCULAR RISK; PPAR-GAMMA; CHOLESTEROL; BERBERINE; PHARMACOLOGY;
   COMBINATION; INHIBITION
AB Objective: Our goal in this study aims to explain the polypharmacological mechanism at the molecular level responsible for the effectiveness of a traditional Chinese medicine (TCM) prescription FTZ to treat hyperlipidernia and related disease.
   Design: By MDL (R) ISIS_Base 2.5, we constructed a compound database based on the FTZ constituents, which were detected in the rat serum after oral administration of the TCM through ultra-performance liquid chromatography/quadruple-time-of-flight mass-spectrometry (UPLC/Q-TOF-MS/MS) method. After validation of the virtual docking system, we used molecular screening by LigandFit which is a computational method for the shape-directed rapid docking of ligands to target protein active sites, to investigate the interactions between the components in database and lipid-modulating targets in the liver.
   Results: In the prescription FTZ ingredients, there were sixteen constituents including jatrorrhizine, etc. showed potential effects towards the hyperlipidemia-related targets: HMG-CoA reductase (HMGR), squalene synthase (SQS), oxidosqualene cyclase (OSC), cholesteryl ester transfer protein (CETP), liver X receptor (LXR), farnesoid X receptor (FXR) and peroxisorne proliferator-activated receptors (PPAR(alpha) and PPAR(gamma)). Among the eight herbs in prescription FTZ, Rhizoma Coptidis (RC) plays the most important role in whole effect from FTZ on hyperlipidemia related disease.
   Conclusions: Our research demonstrated that Chinese medicine formula FTZ has multi-target synergistic effect on hyperlipidemia and suggests the pharmacodynamic material basis could be jatrorrhizine, berberrubine, berberine and salidroside. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Wang, Laiyou; Luo, Duosheng; Hu, Yinming; Bei, Weijian; Guo, Jiao] Guangdong Pharmaceut Univ, Key Unit Modulating Liver Treat Hyperlipidemia SA, Level Lab Lipid Metab SATCM 3,Guangzhou Higher Ed, Guangdong TCM Key Lab Metab Dis,Inst Chinese Med, Guangzhou 510006, Guangdong, Peoples R China.
   [Tao, Weiye] Guangdong Pharmaceut Univ, Guangzhou Higher Educ Mega Ctr, Coll Med Informat Engn, Guangzhou 510006, Guangdong, Peoples R China.
C3 Guangdong Pharmaceutical University; Guangdong Pharmaceutical University
RP Guo, J (corresponding author), Guangdong Pharmaceut Univ, Key Unit Modulating Liver Treat Hyperlipidemia SA, Level Lab Lipid Metab SATCM 3,Guangzhou Higher Ed, Guangdong TCM Key Lab Metab Dis,Inst Chinese Med, Guangzhou 510006, Guangdong, Peoples R China.
EM jiaoguo_gdpu@hotmail.com
RI ; Bei, Weijian/K-5208-2015; Guo, Jiao/PFK-0669-2025
OI Guo, Jiao/0000-0002-0050-5055; 
FU Natural Science Foundation of Guangdong Province, China
   [S2013010015021]; National Science Foundation of China [81102502];
   Scientific Research Foundation for the Returned Overseas Chinese
   Scholars, State Education Ministry, China [46]; CSC
FX This work is supported by the grants from Natural Science Foundation of
   Guangdong Province, China (No. S2013010015021), National Science
   Foundation of China (No. 81102502), and the Scientific Research
   Foundation for the Returned Overseas Chinese Scholars, State Education
   Ministry, China (Batch No. 46). We also appreciate the scholarship from
   CSC fund to Laiyou Wang. The authors wish to thank Professor Xu Jun in
   School of Pharmaceutical Sciences, Sun Yat-sen University, for his
   software provision for the molecular docking during the study.
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NR 30
TC 11
Z9 18
U1 0
U2 40
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0965-2299
EI 1873-6963
J9 COMPLEMENT THER MED
JI Complement. Ther. Med.
PD OCT
PY 2014
VL 22
IS 5
BP 887
EP 893
DI 10.1016/j.ctim.2014.08.002
PG 7
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA AS3UO
UT WOS:000344203700008
PM 25440380
DA 2026-05-27
ER

PT J
AU Bolanle, IO
   Beaufort, GCD
   Weinberg, PD
AF Bolanle, Israel O.
   Beaufort, Gaetan C. de Liedekerke
   Weinberg, Peter D.
TI Transcytosis of LDL Across Arterial Endothelium: Mechanisms and
   Therapeutic Targets
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Review
DE caveolae; cholesterol; coronary disease; permeability
ID LOW-DENSITY-LIPOPROTEIN; PLASMALEMMAL VESICULAR SYSTEM; COUPLED
   ESTROGEN-RECEPTOR; NF-KAPPA-B; 3-DIMENSIONAL ORGANIZATION; SR-BI;
   TRANSENDOTHELIAL TRANSPORT; CAPILLARY-PERMEABILITY; CULTURED
   ENDOTHELIUM; ALBUMIN TRANSCYTOSIS
AB Transport of LDL (low-density lipoprotein) from plasma to arterial intima is thought to be rate limiting in the development of atherosclerosis. Its variation likely determines where lesions develop within arteries and might account for some of the currently unexplained difference in disease susceptibility between individuals. It may also be critical in the development of lipid-rich, unstable plaques. Mechanisms have been controversial but recent evidence suggests that caveolar transcytosis across endothelial cells is the dominant pathway. Receptors involved are LDLR (LDL receptor), SR-B1 (scavenger receptor class B type 1), and ALK1 (activin receptor-like kinase 1). The role of LDLR is influenced by IL-1 beta (interleukin-1 beta); the role of SR-B1 by HDL (high-density lipoprotein), DOCK4 (dedicator of cytokinesis 4), GPER (G-protein-coupled estrogen receptor), and HMGB1 (high mobility group box 1); and the role of ALK1 by BMP (bone morphogenetic protein) 9. Additionally, BMP4 stimulates transcytosis and FSTL1 (follistatin-like 1 protein) inhibits it. Fundamental transcytotic mechanisms include caveola formation, undocking, trafficking, and docking; they are influenced by cholesterol-lowering agents, MYDGF (myeloid-derived growth factor), MFSD2a (major facilitator superfamily domain containing 2a) in the blood-brain barrier, and inhibitors of dynamin-2 and tubulin polymerization. The relative merits of different therapeutic approaches are discussed, with statins, colchicine, benzimidazoles, and metformin being existing drugs that might be repurposed and salidroside and glycyrrhizic acid being nutraceuticals worth investigating. Finally, we discuss evidence against the ferry-boat model of transcytosis, the contributions of receptor-mediated, fluid-phase, and active transcytosis, and where inhibition of transcytosis might be most beneficial.
C1 [Bolanle, Israel O.; Weinberg, Peter D.] Imperial Coll London, Dept Bioengn, London SW7 2AZ, England.
C3 Imperial College London
RP Weinberg, PD (corresponding author), Imperial Coll London, Dept Bioengn, London SW7 2AZ, England.
EM p.weinberg@imperial.ac.uk
OI Weinberg, Peter David/0000-0001-6114-5498; Bolanle, Israel
   Olapeju/0000-0002-4638-6522
FU British Heart Foundation [PG/23/11466]
FX LO. Bolanle was supported by project grant PG/23/11466 from the British
   Heart Foundation
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NR 114
TC 14
Z9 17
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1079-5642
EI 1524-4636
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD APR
PY 2025
VL 45
IS 4
BP 468
EP 480
DI 10.1161/ATVBAHA.124.321549
PG 13
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 0MC8Y
UT WOS:001450635500005
PM 40013359
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Gerbarg, PL
   Brown, RP
AF Gerbarg, Patricia L.
   Brown, Richard P.
TI Pause menopause with Rhodiola rosea, a natural selective estrogen
   receptor modulator
SO PHYTOMEDICINE
LA English
DT Article
DE Menopause; Selective estrogen receptor modulator; Rhodiola rosea;
   Cognitive function; Cardiovascular
ID ISOLATED NEUROGLIAL CELLS; PLUS PROGESTIN; COGNITIVE FUNCTION;
   RANDOMIZED-TRIAL; EXTRACT SHR-5; HEART-DISEASE; FRACTURE RISK;
   DOUBLE-BLIND; IN-VITRO; SALIDROSIDE
AB Background: Menopausal women are challenged by the adverse effects of estrogen loss on energy, mood, cognitive function, and memory. These stresses are compounded by increased risks for cardiovascular disease, osteoporosis, and cancer. Known to have neuroprotective, cardio-protective, anti-oxidative and anticarcinogenic effects, Rhodiola rosea extracts have also been shown to improve energy, mood, cognitive function and memory.
   Purpose: We propose that R. rosea be investigated for use as a potential selective estrogen receptor modulator (SERM) in the prevention and treatment of menopause-related fatigue, stress, depression, cognitive decline, memory impairment, cardiovascular disease, osteoporosis and cancer.
   Method: This paper briefly reviews the relationship between estrogen decline and menopause-related health risks, the molecular mechanisms underlying estrogenic effects on health, and the evidence indicating beneficial effects of R. rosea extracts on these mechanisms and health risks. Mechanisms include nongenomic and genomic effects, for example: activation of intra-cellular signal transduction pathways by binding to estrogen receptors, ER alpha-mediated activation of endothelial nitric oxide synthase with increased nitric oxide release; and anti-inflammatory effects, counteracting TNF alpha by inhibiting nuclear factor-Kappa-B (NF-kappa B) and protection of osteoblasts from hydrogen peroxide. A clinical case illustrating treatment of a menopausal woman with R. rosea is presented. Risks, benefits, gaps in knowledge, and future directions are discussed.
   Conclusion: Numerous lines of evidence indicate that R. rosea should be investigated as a potential selective estrogen receptor modulator (SERM) to prevent, delay or mitigate menopause-related cognitive, psychological, cardiovascular and osteoporotic conditions. (C) 2015 Elsevier GmbH. All rights reserved.
C1 [Gerbarg, Patricia L.] New York Med Coll, 86 Sherry Lane, Kingston, NY 12401 USA.
   [Brown, Richard P.] Columbia Univ, Coll Med, 86 Sherry Lane, Kingston, NY 12401 USA.
C3 New York Medical College
RP Gerbarg, PL (corresponding author), New York Med Coll, 86 Sherry Lane, Kingston, NY 12401 USA.
EM PGerbarg@aol.com
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NR 59
TC 26
Z9 33
U1 0
U2 41
PU ELSEVIER GMBH, URBAN & FISCHER VERLAG
PI JENA
PA OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY
SN 0944-7113
J9 PHYTOMEDICINE
JI Phytomedicine
PD JUN 15
PY 2016
VL 23
IS 7
BP 763
EP 769
DI 10.1016/j.phymed.2015.11.013
PG 7
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA DM7IM
UT WOS:000376533500010
PM 26776957
DA 2026-05-27
ER

PT J
AU Hou, K
   Cao, L
   Li, W
   Fang, ZH
   Sun, DQ
   Guo, ZG
   Zhang, LP
AF Hou, Kai
   Cao, Lu
   Li, Wen
   Fang, Zhi-Hui
   Sun, Daqiang
   Guo, Zhigang
   Zhang, Lipeng
TI Overexpression of Rhodiola crenulata glutathione peroxidase 5
   increases cold tolerance and enhances the pharmaceutical value of the
   hairy roots
SO GENE
LA English
DT Article
DE Rhodiola crenulata; RcGPX5; Cold tolerance; Arabidopsis; Abscisic acid;
   Doxorubicin-induced cardiotoxicity
ID STRESS TOLERANCE; DROUGHT STRESS; ARABIDOPSIS; REDOX; ACCLIMATION;
   HOMEOSTASIS; PLANTS; GENES; ROS
AB Rhodiola crenulata , a plant of great medicinal value found in cold high -altitude regions, has been excessively exploited due to the difficulty in cultivation. Understanding Rhodiola crenulata's adaptation mechanisms to cold environment can provide a theoretical basis for artificial breeding. Glutathione peroxidases (GPXs), critical enzymes found in plants, play essential roles in antioxidant defense through the ascorbate - glutathione cycle. However, it is unknown whether GPX5 contributes to Rhodiola crenulata ' s cold tolerance. In this study, we investigated the role of GPX5 in Rhodiola crenulata ' s cold tolerance mechanisms. By overexpressing Rhodiola crenulata GPX5 ( RcGPX5 ) in yeast and Arabidopsis thaliana , we observed down -regulation of Arabidopsis thaliana GPX5 ( AtGPX5 ) and increased cold tolerance in both organisms. Furthermore, the levels of antioxidants and enzyme activities in the ascorbate - glutathione cycle were elevated, and cold -responsive genes such as AtCBFs and AtCORs were induced. Additionally, RcGPX5 overexpressing lines showed insensitivity to exogenous abscisic acid (ABA), suggesting a negative regulation of the ABA pathway by RcGPX5 . RcGPX5 also promoted the expression of several thioredoxin genes in Arabidopsis and interacted with two endogenous genes of Rhodiola crenulata , RcTrx2-3 and RcTrxo1 , located in mitochondria and chloroplasts. These findings suggest a significantly different model in Rhodiola crenulata compared to Arabidopsis thaliana , highlighting a complex network involving the function of RcGPX5 . Moreover, overexpressing RcGPX5 in Rhodiola crenulata hairy roots positively influenced the salidroside synthesis pathway, enhancing its pharmaceutical value for doxorubicin-induced cardiotoxicity. These results suggested that RcGPX5 might be a key component for Rhodiola crenulata to adapt to cold stress and overexpressing RcGPX5 could enhance the pharmaceutical value of the hairy roots.
C1 [Hou, Kai; Li, Wen; Fang, Zhi-Hui] Puer Peoples Hosp, Puer, Yunnan, Peoples R China.
   [Hou, Kai; Cao, Lu; Sun, Daqiang; Guo, Zhigang] Tianjin Chest Hosp, Tianjin, Peoples R China.
   [Hou, Kai; Cao, Lu; Sun, Daqiang; Guo, Zhigang] Tianjin Univ, Chest Hosp, Tianjin, Peoples R China.
   [Hou, Kai; Sun, Daqiang; Guo, Zhigang] Tianjin Med Univ, Tianjin, Peoples R China.
   [Zhang, Lipeng] Tianjin Univ Commerce, Sch Biotechnol & Food Sci, Tianjin, Peoples R China.
C3 Tianjin University; Tianjin University; Tianjin Medical University;
   Tianjin University of Commerce
RP Sun, DQ; Guo, ZG (corresponding author), Tianjin Chest Hosp, Tianjin, Peoples R China.; Sun, DQ; Guo, ZG (corresponding author), Tianjin Univ, Chest Hosp, Tianjin, Peoples R China.; Sun, DQ; Guo, ZG (corresponding author), Tianjin Med Univ, Tianjin, Peoples R China.; Zhang, LP (corresponding author), Tianjin Univ Commerce, Sch Biotechnol & Food Sci, Tianjin, Peoples R China.
EM sdqmd@tju.edu.cn; Zhigangguo2022@126.com; zhanglp@tjcu.edu.cn
RI Sun, Daqiang/LEM-2104-2024; CAO, LU/JAO-4115-2023
OI Sun, Daqiang/0009-0000-6602-357X; Hou, Kai/0000-0001-7014-741X; Fang,
   Zhi-Hui/0009-0004-0131-9571; 
FU National Natural Science Foundation of China [82200310]; Tianjin Key
   Medical Discipline (Specialty) Construction Project [TJYXZDXK-018A,
   TJYXZDXK-042A, TJYXZDXK-055B]; Yunnan Medical Doctor Association STAR
   Imaging Research Special Project [YN-2022-S-01]; Kunming University of
   Science and Technology-Pu'er People's Hospital Medical Special Project
   [KUST-PE2022009Y]
FX This research was funded by the National Natural Science Foundation of
   China (82200310) , Tianjin Key Medical Discipline (Specialty)
   Construction Project (TJYXZDXK-018A, TJYXZDXK-042A, and TJYXZDXK-055B) ,
   Kunming University of Science and Technology-Pu'er People's Hospital
   Medical Special Project (KUST-PE2022009Y) , and Yunnan Medical Doctor
   Association STAR Imaging Research Special Project (YN-2022-S-01) .
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NR 59
TC 4
Z9 4
U1 6
U2 39
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0378-1119
EI 1879-0038
J9 GENE
JI Gene
PD JUL 30
PY 2024
VL 917
AR 148467
DI 10.1016/j.gene.2024.148467
EA APR 2024
PG 16
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA TZ2N0
UT WOS:001245015600001
PM 38615983
DA 2026-05-27
ER

PT J
AU Pang, ZQ
   Ran, N
   Yuan, YZ
   Wang, CZ
   Wang, GQ
   Lin, HQ
   Hsu, ACY
   Liu, JP
   Wang, F
AF Pang, Zhiqiang
   Ran, Nan
   Yuan, Yuze
   Wang, Cuizhu
   Wang, Guoqiang
   Lin, Hongqiang
   Hsu, Alan Chen-Yu
   Liu, Jinping
   Wang, Fang
TI Phenotype-Specific Therapeutic Effect of Rhodiola wallichiana
   var. cholaensis Combined with Dexamethasone on Experimental
   Murine Asthma and Its Comprehensive Pharmacological Mechanism
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE asthma; Rhodiola wallichiana var; cholaensis; dexamethasone; phenotype;
   multiomics
ID ALLERGIC AIRWAY INFLAMMATION; NON-EOSINOPHILIC ASTHMA; MICROBIOME;
   SALIDROSIDE; CELLS; RNA; MEPOLIZUMAB; SIGNATURES; INFECTION; RESPONSES
AB The heterogeneity of asthma involves complex pathogenesis leading to confusion regarding the choice of therapeutic strategy. In the clinic, asthma is commonly classified as having either eosinophilic asthma (EA) or non-eosinophilic asthma (NEA) phenotypes. Microbiota colonizing in airways has been demonstrated to induce distinct phenotypes of asthma and the resistance to steroids. Rhodiola wallichiana var. cholaensis (RWC) has the potential to alleviate asthmatic inflammation according to recent studies, but its pharmacological mechanisms remain unclarified. In our study, murine asthmatic phenotypes were established and treated with RWC and/or dexamethasone (DEX). Combined treatment with RWC and DEX could improve spirometry and airway hyperresponsiveness (AHR) in asthmatic phenotypes, alleviate steroid resistance in NEA, and reduce the inflammatory infiltration of the both phenotypes. The combined treatment increased Th1, regulated the imbalance of Th2/Th1, and decreased the related cytokines in EA. As for NEA, the combined treatment reduced Th17 and promoted the accumulation of regulatory T cells (Tregs) in lung. A microbiome study based on 16S rDNA sequencing technique revealed the significantly changed structure of the lower airway microbiota after combined treatment in NEA, with 4 distinct genera and 2 species identified. OPLS-DA models of metabolomics analysis based on UPLC-Q/TOF-MS technique identified 34 differentiated metabolites and 8 perturbed metabolic pathways. A joint multiomics study predicted that the colonized microbiota in airways might be associated with susceptibility of asthma and steroid resistance, which involved systematic and pulmonary metabolic perturbation. In summary, the pharmacological network of RWC included the complicated interaction mechanisms of immune regulation, microbiota change, and metabolic perturbation.
C1 [Pang, Zhiqiang; Ran, Nan; Yuan, Yuze; Wang, Cuizhu; Wang, Guoqiang; Wang, Fang] Jilin Univ, Dept Pathogen Biol, Coll Basic Med Sci, Changchun 130021, Jilin, Peoples R China.
   [Wang, Cuizhu; Lin, Hongqiang; Liu, Jinping] Jilin Univ, Sch Pharmaceut Sci, Res Ctr Nat Drug, Changchun 130012, Jilin, Peoples R China.
   [Hsu, Alan Chen-Yu] Univ Newcastle, Sch Med & Publ Hlth, Fac Hlth & Med, Callaghan, NSW 2308, Australia.
   [Wang, Fang] Jilin Univ, Coll Vet Med, Key Lab Zoonosis, Minist Educ, Changchun 130062, Jilin, Peoples R China.
C3 Jilin University; Jilin University; University of Newcastle; Jilin
   University
RP Wang, F (corresponding author), Jilin Univ, Dept Pathogen Biol, Coll Basic Med Sci, Changchun 130021, Jilin, Peoples R China.; Wang, F (corresponding author), Jilin Univ, Coll Vet Med, Key Lab Zoonosis, Minist Educ, Changchun 130062, Jilin, Peoples R China.
EM wf@jlu.edu.cn
RI ; Hsu, Alan/A-3144-2012
OI Wang, Guoqiang/0000-0001-5732-8144; Hsu, Alan/0000-0002-6640-0846
FU Provincial School Co-construction Industrialization Demonstration
   Project of Jilin Province [SXGJSF2017-1-1(01)]; Fundamental Research
   Funds for the Central Universities; Graduate Innovation Fund of Jilin
   University [101832018C060]
FX This research is funded by Provincial School Co-construction
   Industrialization Demonstration Project of Jilin Province [Grant No.
   SXGJSF2017-1-1(01)], Fundamental Research Funds for the Central
   Universities, and Graduate Innovation Fund of Jilin University [Grant
   No. 101832018C060].
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NR 81
TC 8
Z9 9
U1 0
U2 22
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD SEP 1
PY 2019
VL 20
IS 17
AR 4216
DI 10.3390/ijms20174216
PG 28
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA IZ2AF
UT WOS:000486888400148
PM 31466312
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhang, XX
   Jiang, XW
   Wang, X
   Zhao, YY
   Jia, LQ
   Chen, F
   Yin, R
   Han, F
AF Zhang, Xiaoxue
   Jiang, Xiwei
   Wang, Xue
   Zhao, Yangyang
   Jia, Lianqun
   Chen, Fen
   Yin, Ran
   Han, Fei
TI A metabolomic study based on accurate mass and isotopic fine structures
   by dual mode combined-FT-ICR-MS to explore the effects of Rhodiola
   crenulata extract on Alzheimer disease in rats
SO JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
LA English
DT Article
DE FT-ICR-MS; tRaditional Chinese medicines; Rhodiola crenulata;
   Metabolomic study; Accurate mass; Isotopic fine structures
ID TRADITIONAL CHINESE MEDICINE; COGNITIVE IMPAIRMENT; SPECTROMETRY;
   METABOLITES; RESOLUTION; COMBINATION; MEDIATORS; SALIDROSIDE; DISCOVERY;
   STRATEGY
AB A metabolomic strategy based on accurate mass and isotopic fine structures (IFSs) by dual mode combined-Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS) was established to explore the effects of Rhodiola crenulata extract (RCE) on Alzheimer disease (AD) in rats. Experimental AD model was induced in rats by bilateral hippocampal injection of A beta(1-42), and Morris water maze task (MWM) was used to evaluate the effects of RCE on AD. Subsequently, the metabolomic study was performed using HPLC-FT-ICR-MS, fraction collector and direct infusion (DI)-FT-ICR-MS to screen and identify the potential biomarkers. A total of 20 metabolites contributing to AD progress were identified, and 17 metabolites of them were restored to the control-like levels after RCE treatment (daily dose: 2.24 g/kg). The metabolic pathway analysis revealed that the disturbed pathways including tryptophan metabolism, sphingolipid metabolism and glycerophospholipid metabolism in AD model rats were regulated after high dose RCE application. It is the first time that the dual mode combined-FT-ICR-MS based metabolomic strategy was applied to biochemically profile the serum metabolic pathways of AD rats affected by RCE. These outcomes provide reliable evidence to illuminate the biochemical mechanisms of AD and facilitate investigation of the therapeutic benefits of RCE in AD treatment. Notably, it indicated that the developed method based on accurate mass and IFSs has sufficient performance for identification of biomarkers in metabolomic studies. (C) 2019 Elsevier B.V. All rights reserved.
C1 [Zhang, Xiaoxue; Wang, Xue; Zhao, Yangyang; Yin, Ran; Han, Fei] Shenyang Pharmaceut Univ, Sch Pharm, 103 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China.
   [Jiang, Xiwei] Shenyang Pharmaceut Univ, Sch Med Devices, 103 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China.
   [Jia, Lianqun; Chen, Fen] Liaoning Univ Tradit Chinese Med, Minist Educ TCM Viscera State Theory & Applicat, Key Lab, 79 Chongshan Eastern Rd, Shenyang 110032, Liaoning, Peoples R China.
C3 Shenyang Pharmaceutical University; Shenyang Pharmaceutical University;
   Liaoning University of Traditional Chinese Medicine
RP Han, F (corresponding author), Shenyang Pharmaceut Univ, Sch Pharm, 103 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China.
EM hanfei_spu@163.com
FU National Natural Science Foundation of China [81673573]; Open fund of
   Key Laboratory of Ministry of Education for TCM Viscera-State Theory and
   Applications, Liaoning University of Traditional Chinese Medicine [zyzxl
   707]; Liaoning Student's Platform for Innovation and Entrepreneurship
   Program [201810163009]
FX This research was supported by the National Natural Science Foundation
   of China (No. 81673573), the Open fund of Key Laboratory of Ministry of
   Education for TCM Viscera-State Theory and Applications, Liaoning
   University of Traditional Chinese Medicine (No. zyzxl 707) and the
   Liaoning Student's Platform for Innovation and Entrepreneurship Program
   (No. 201810163009).
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NR 52
TC 15
Z9 18
U1 2
U2 66
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0731-7085
EI 1873-264X
J9 J PHARMACEUT BIOMED
JI J. Pharm. Biomed. Anal.
PD MAR 20
PY 2019
VL 166
BP 347
EP 356
DI 10.1016/j.jpba.2019.01.021
PG 10
WC Chemistry, Analytical; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Pharmacology & Pharmacy
GA HO2AL
UT WOS:000460713700040
PM 30690248
DA 2026-05-27
ER

PT J
AU Luo, F
   Zhou, R
   Lei, H
   Mou, Y
   Zhang, P
   Sun, Y
   Chen, T
   He, L
   Yan, TH
AF Luo, Fen
   Zhou, Rui
   Lei, Hui
   Mou, Yi
   Zhang, Ping
   Sun, Yi
   Chen, Tong
   He, Ling
   Yan, Tianhua
TI Umbelliferone attenuates lipopolysaccharide-induced acute lung injury
   linked with regulation of TLRs-MyD88 and RIP140/NF-κB signaling pathways
SO RSC ADVANCES
LA English
DT Article
ID TIMOSAPONIN B-II; IN-VIVO; INFLAMMATION; APOPTOSIS; CHRYSOPHANOL; MODEL;
   SALIDROSIDE; DEPRESSION; ESCULETIN; TRILLIN
AB Umbelliferone (Umb), isolated from the chloroform fraction of Potentilla evestita, exerts a variety of pharmacological activities. The aim of the present study was to evaluate the protective effects and possible mechanisms of Umb on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. Male BALB/c mice were randomly divided into five groups: control group, LPS group, LPS + dexamethasone (Dex, 2 mg kg(-1)) group, LPS + Umb (20 mg kg(-1)) group, and LPS + Umb (Umb, 40 mg kg(-1)) group. Umb and Dex were orally administered 15 min before the intra-tracheal (IT) administration of LPS. 6 h later, the mice were sacrificed. The lung tissues and bronchoalveolar fluid (BALF) were prepared for further analysis. Our results showed that pretreatment with Umb prior to the LPS challenge significantly decreased the lung W/D weight ratio, total leukocyte number and neutrophil percentage in the BALF. Umb also reduced pulmonary MPO activity and alleviated histopathological alteration. Besides, the contents of inflammatory cytokines including interleukin (IL)-6, interleukin (IL)-1 beta and tumor neurosis factor (TNF)-alpha were also found to be significantly inhibited by Umb in BALF. Furthermore, the expressions of TLR2, TLR4, MyD88, receptor-interacting protein 140 (RIP140), RelA, CBP, nuclear factor kappa B (NF-kappa B), caspase-9, caspase-3, Bax in lung tissues were inhibited and Bcl-2 expression was increased in the LPS + Umb group. These results showed that administration of Umb could attenuate LPS-induced ALI, possibly via the anti-inflammatory and anti-apoptotic activities through the TLRs-MyD88 and RIP140/NF-kappa B pathway.
C1 [Luo, Fen; Zhou, Rui; Yan, Tianhua] China Pharmaceut Univ, Dept Physiol & Pharmacol, Nanjing 210009, Jiangsu, Peoples R China.
   [Lei, Hui] Pharmaceut Expt Ctr China Pharmaceut Univ, Nanjing 211198, Jiangsu, Peoples R China.
   [Mou, Yi] Taizhou Univ, Taizhou 225300, Peoples R China.
   [Zhang, Ping; Sun, Yi; Chen, Tong; He, Ling] China Pharmaceut Univ, Dept Pharmaceut, Nanjing 210009, Jiangsu, Peoples R China.
   [Chen, Tong] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China.
C3 China Pharmaceutical University; Taizhou University - Jiangsu; China
   Pharmaceutical University; China Pharmaceutical University
RP Yan, TH (corresponding author), China Pharmaceut Univ, Dept Physiol & Pharmacol, Nanjing 210009, Jiangsu, Peoples R China.; He, L (corresponding author), China Pharmaceut Univ, Dept Pharmaceut, Nanjing 210009, Jiangsu, Peoples R China.
EM heling92@hotmail.com; yantianhuabest@126.com
RI Su, Tianyuan/Y-7054-2019; zhou, rui/KZT-9353-2024
FU National 12th Five year Plan "Major Scientific and Technological Special
   Project for Significant New Drugs Creation" [2012ZX09504001-001];
   National Natural Science Foundation of China (NSFC) [81673434]; National
   Twelve Five Major Drug Discovery Project [2011ZX09102-002-01]
FX The study was supported by National 12th Five year Plan "Major
   Scientific and Technological Special Project for Significant New Drugs
   Creation" (no. 2012ZX09504001-001), National Natural Science Foundation
   of China (NSFC no. 81673434) and National Twelve Five Major Drug
   Discovery Project (no. 2011ZX09102-002-01).
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NR 41
TC 9
Z9 10
U1 2
U2 15
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
EI 2046-2069
J9 RSC ADV
JI RSC Adv.
PY 2016
VL 6
IS 100
BP 97503
EP 97511
DI 10.1039/c6ra18293c
PG 9
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA EA0XO
UT WOS:000386312700005
DA 2026-05-27
ER

PT J
AU Chuang, ML
   Wu, TC
   Wang, YT
   Wang, YC
   Tsao, TCY
   Wei, JCC
   Chen, CY
   Lin, IF
AF Chuang, Ming-Lung
   Wu, Tzu-Chin
   Wang, Yau-Tung
   Wang, Yau-Chen
   Tsao, Thomas C. -Y.
   Wei, James Cheng-Chung
   Chen, Chia-Yin
   Lin, I-Feng
TI Adjunctive Treatment with Rhodiola Crenulata in Patients with Chronic
   Obstructive Pulmonary Disease - A Randomized Placebo Controlled Double
   Blind Clinical Trial
SO PLOS ONE
LA English
DT Article
ID C-REACTIVE PROTEIN; SYSTEMIC INFLAMMATION; EXTRACT SHR-5; LUNG-FUNCTION;
   HEALTH-STATUS; ROSEA; PERFORMANCE; SALIDROSIDE; COMBINATION; ROFLUMILAST
AB Chronic obstructive pulmonary disease (COPD) is a low grade systemic inflammatory disease characterized by dyspnea and exercise intolerance even under standard therapy. Rhodiola crenulata (RC) has been shown to exert anti-inflammatory effects and to enhance exercise endurance, thereby having the potential to treat COPD. In this 12-week, randomized, double-blind, placebo-controlled clinical trial, 57 patients with stable moderate-to-severe COPD aged 70 +/- 8.8 years were given RC (250 mg twice/day) (n=38) or a placebo (250 mg twice/day) (n=19) in addition to their standard regimen. There were no significant differences in anthropometrics, quality of life, lung function, six-minute walk and incremental exercise tests between the two groups at enrollment. Over the 12 weeks, RC was well tolerated, significantly reduced triceps skin thickness (Delta=-1 mm, p = .04), change of FEV1 (4.5%, p = .03), and improved workload (Delta=10%, p = .01); although there were no significant differences in these factors between the two groups. However, there were significant between-group differences in tidal volume and ventilation-CO2-output ratio at peak exercise (both p = .05), which were significantly related to peak work rate (both p<.0001). RC tended to protect against acute exacerbation of COPD (p = .1) but not other measurements. RC did not improve the six-minute walk test distance but significantly improved tidal breathing and ventilation efficiency, most likely through improvements in work rate. Further studies with a larger patient population are needed in order to confirm these findings.
C1 [Chuang, Ming-Lung; Wu, Tzu-Chin; Wang, Yau-Tung; Wang, Yau-Chen; Tsao, Thomas C. -Y.] Chung Shan Med Univ Hosp, Div Pulm Med, Taichung 40201, Taiwan.
   [Chuang, Ming-Lung; Wu, Tzu-Chin; Wang, Yau-Tung; Wang, Yau-Chen; Tsao, Thomas C. -Y.] Chung Shan Med Univ Hosp, Dept Crit Care Med, Taichung 40201, Taiwan.
   [Chuang, Ming-Lung; Wu, Tzu-Chin; Wang, Yau-Tung; Wang, Yau-Chen; Tsao, Thomas C. -Y.; Wei, James Cheng-Chung] Chung Shan Med Univ, Sch Med, Taichung, Taiwan.
   [Wei, James Cheng-Chung; Chen, Chia-Yin] Chung Shan Med Univ Hosp, Chinese Med Clin Trial Ctr, Taichung 40201, Taiwan.
   [Wei, James Cheng-Chung] Chung Shan Med Univ, Inst Med, Taichung, Taiwan.
   [Wei, James Cheng-Chung] China Med Univ, Grad Inst Integrated Med, Taichung, Taiwan.
   [Lin, I-Feng] Natl Yang Ming Univ, Inst & Dept Publ Hlth, Taipei 112, Taiwan.
C3 Chung Shan Medical University; Chung Shan Medical University Hospital;
   Chung Shan Medical University; Chung Shan Medical University Hospital;
   Chung Shan Medical University; Chung Shan Medical University; Chung Shan
   Medical University Hospital; Chung Shan Medical University; China
   Medical University Taiwan; National Yang Ming Chiao Tung University
RP Chuang, ML (corresponding author), Chung Shan Med Univ Hosp, Dept Crit Care Med, Taichung 40201, Taiwan.
EM yuan1007@ms36.hinet.net; cshy1292@csh.org.tw
RI Wei, James Cheng-Chung/AAL-8947-2020
OI Wei, James Cheng-Chung/0000-0002-1235-0679
FU Chung Shan Medical University Hospital, Taichung, Taiwan [CSH-2012-C-23]
FX Funding provided by Chung Shan Medical University Hospital, Taichung,
   Taiwan Registration number: CSH-2012-C-23. The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 43
TC 12
Z9 16
U1 3
U2 21
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 22
PY 2015
VL 10
IS 6
AR e0128142
DI 10.1371/journal.pone.0128142
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CL3FM
UT WOS:000356835800012
PM 26098419
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Cheng, J
   Li, JH
   Xiong, RG
   Zhou, DD
   Huang, SY
   Wu, SX
   Shang, A
   Tang, GY
   Li, HB
   Gan, RY
AF Cheng, Jin
   Li, Jiahui
   Xiong, Ruo-Gu
   Zhou, Dan-Dan
   Huang, Si-Yu
   Wu, Si-Xia
   Shang, Ao
   Tang, Guo-Yi
   Li, Hua-Bin
   Gan, Ren-You
TI Potentially harmful effects of micro-/nanoplastics on humans as well as
   protective actions of dietary natural products
SO TRENDS IN FOOD SCIENCE & TECHNOLOGY
LA English
DT Article
DE Microplastics; Nanoplastics; Harmful effects; Dietary natural products
ID MICROPLASTICS; NANOPLASTICS
AB Background: Microplastics and nanoplastics are hot research topics in many fields (e.g., food science, nutrition, environment, ecology and toxicology). They have potentially harmful effects on humans, such as neurotoxicity, carcinogenicity and reproductive toxicity. Humans are exposed to microplastics and nanoplastics through food, drinking water and air. Thus, it is necessary to discover dietary natural products that can protect against these harmful effects caused by microplastics and nanoplastics. Scope and approach: This review summarizes potentially harmful effects and underlying mechanisms of microplastics and nanoplastics on humans, according to high-quality literature from Web of Science and PubMed databases. Furthermore, dietary natural products that can protect humans against these harmful effects are also summarized and discussed. Key findings and conclusions: Microplastics and nanoplastics have been detected in many organs of humans, such as the colon, placenta, and heart. Epidemiological studies indicate that microplastics are positively associated with colorectal cancer, myocardial infarction, stroke, and even death. Experimental studies demonstrate that microplastics and nanoplastics have carcinogenicity, neurotoxicity, reproductive toxicity, development toxicity, hepatoxicity, as well as nephrotoxicity, and can induce intestinal dysfunction, diabetes, obesity and cardiovascular diseases. On the other hand, some dietary natural products, such as probiotics, chrysoeriol, salidroside, resveratrol, herbacetin, melatonin, quercetin, and vitamin D, can ameliorate toxicities induced by microplastics and nanoplastics. In the future, priorities should be implemented to discover more dietary natural products that can protect humans from the toxicities of microplastics and nanoplastics. Overall, we hope that this review can attract more attention to the harmful effects of microplastics and nanoplastics and also highlight the potential protective actions of dietary natural products against them.
C1 [Cheng, Jin; Xiong, Ruo-Gu; Huang, Si-Yu; Wu, Si-Xia; Li, Hua-Bin] Sun Yat Sen Univ, Sch Publ Hlth, Dept Nutr, Guangdong Prov Key Lab Food Nutr & Hlth, Guangzhou 510080, Peoples R China.
   [Li, Jiahui; Shang, Ao; Tang, Guo-Yi] Univ Hong Kong, Li Ka Shing Fac Med, Sch Chinese Med, Hong Kong 999077, Peoples R China.
   [Zhou, Dan-Dan] Chinese Univ Hong Kong, Sch Life Sci, Food & Nutr Sci Program, Hong Kong 999077, Peoples R China.
   [Gan, Ren-You] ASTAR, Singapore Inst Food & Biotechnol Innovat SIFBI, 31 Biopolis Way, Singapore 138669, Singapore.
   [Gan, Ren-You] Hong Kong Polytech Univ, Dept Food Sci & Nutr, Hung Hom, Kowloon, Hong Kong 999077, Peoples R China.
   [Gan, Ren-You] Hong Kong Polytech Univ, Res Inst Future Food, Hung Hom, Kowloon, Hong Kong 999077, Peoples R China.
C3 Sun Yat Sen University; University of Hong Kong; Chinese University of
   Hong Kong; Agency for Science Technology & Research (A*STAR); A*STAR -
   Singapore Institute of Food & Biotechnology Innovation (SIFBI); Hong
   Kong Polytechnic University; Hong Kong Polytechnic University
RP Li, HB (corresponding author), Sun Yat Sen Univ, Sch Publ Hlth, Dept Nutr, Guangdong Prov Key Lab Food Nutr & Hlth, Guangzhou 510080, Peoples R China.; Gan, RY (corresponding author), Hong Kong Polytech Univ, Dept Food Sci & Nutr, Hung Hom, Kowloon, Hong Kong 999077, Peoples R China.
EM lihuabin@mail.sysu.edu.cn; renyou.gan@polyu.edu.hk
RI ; Li, Hua-Bin/AEX-9846-2022; zhou, dandan/OUJ-6442-2025; Li,
   Jiahui/KIE-5089-2024; Gan, Renyou/C-9868-2009
OI TANG, Guoyi/0009-0004-4036-7082; 
FU Key Project of Guangdong Provincial Science and Technology Program
   [2014B020205002]; Start-Up Fund of the Hong Kong Polytechnic University
   [P0053775]
FX This study was funded by the Key Project of Guangdong Provincial Science
   and Technology Program (No. 2014B020205002) and the Start-Up Fund of the
   Hong Kong Polytechnic University (No. P0053775) .
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NR 135
TC 11
Z9 11
U1 24
U2 125
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0924-2244
EI 1879-3053
J9 TRENDS FOOD SCI TECH
JI Trends Food Sci. Technol.
PD FEB
PY 2025
VL 156
AR 104841
DI 10.1016/j.tifs.2024.104841
EA DEC 2024
PG 16
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA R1W4P
UT WOS:001389437700001
DA 2026-05-27
ER

PT J
AU Kostoff, RN
   Briggs, MB
   Shores, DR
AF Kostoff, Ronald Neil
   Briggs, Michael Brandon
   Shores, Darla Roye
TI Treatment repurposing for inflammatory bowel disease using
   literature-related discovery and innovation
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Treatment repurposing; Treatment repositioning; Inflammatory bowel
   disease; Literature-based discovery; Text mining; Crohn's disease;
   Ulcerative colitis; Novel treatments
ID NF-KAPPA-B; RATS; SALIDROSIDE; MACROPHAGES
AB Inflammatory bowel disease (IBD) incidence has been increasing steadily, most dramatically in the Western developed countries. Treatment often includes lifelong immunosuppressive therapy and surgery. There is a critical need to reduce the burden of IBD and to discover medical therapies with better efficacy and fewer potential side-effects. Repurposing of treatments originally studied in other diseases with similar pathogenesis is less costly and time intensive than de novo drug discovery. This study used a treatment repurposing methodology, the literature-related discovery and innovation (LRDI) text mining system, to identify potential treatments (developed for non-IBD diseases) with sufficient promise for extrapolation to treatment of IBD. By searching for desirable patterns of twenty key biomarkers relevant to IBD (e.g., inflammation, reactive oxygen species, autophagy, barrier function), the LRDI-based query retrieved approximately 9500 records from Medline. The most recent 350 records were further analyzed for proof-of-concept. Approximately 18% (64/350) met the criteria for discovery (not previously studied in IBD human or animal models) and relevance for application to IBD treatment. Many of the treatments were compounds derived from herbal remedies, and the majority of treatments were being studied in cancer, diabetes, and central nervous system disease, such as depression and dementia. As further validation of the search strategy, the query identified ten treatments that have just recently begun testing in IBD models in the last three years. Literature-related discovery and innovation text mining contains a unique search strategy with tremendous potential to identify treatments for repurposing. A more comprehensive query with additional key biomarkers would have retrieved many thousands more records, further increasing the yield of IBD treatment repurposing discovery.
C1 [Kostoff, Ronald Neil] Georgia Inst Technol, Sch Publ Policy, 13500 Tallyrand Way, Gainesville, VA 20155 USA.
   [Shores, Darla Roye] Johns Hopkins Univ, Sch Med, Hopkins Resource Intestinal Vital & Enhancement, Baltimore, MD 21287 USA.
C3 University System of Georgia; Georgia Institute of Technology; Johns
   Hopkins University
RP Kostoff, RN (corresponding author), Georgia Inst Technol, Sch Publ Policy, 13500 Tallyrand Way, Gainesville, VA 20155 USA.
EM ronald.kostoff@pubpolicy.gatech.edu
RI Shores, Darla/GXH-2652-2022
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NR 95
TC 7
Z9 10
U1 0
U2 32
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD SEP 7
PY 2020
VL 26
IS 33
DI 10.3748/wjg.v26.i33.4889
PG 12
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA NQ9FN
UT WOS:000571172100001
PM 32952337
OA Green Accepted
DA 2026-05-27
ER

PT J
AU Paul, S
   Zhang, XM
   Yang, YP
   Geng, CA
AF Paul, Swastika
   Zhang, Xuemei
   Yang, Yongping
   Geng, Changan
TI Chemical Constituents from Turnip and Their Effects on α-Glucosidase
SO PHYTON-INTERNATIONAL JOURNAL OF EXPERIMENTAL BOTANY
LA English
DT Article
DE Brassica rapa; turnip; alpha-glucosidase; licochalcone A; docking study
ID BRASSICA-RAPA; ETHANOL EXTRACT; ROOTS; LEAVES; L.
AB Brassica rapa var. rapa (turnip) is an important crop in Qinghai-Tibet Plateau (QTP) with anti-hypoxic effect. Turnip is rich in glucosinolates, isothiocyanates and phenolic compounds with diverse biological activities, involving anti-oxidant, anti-tumor, anti-diabetic, anti-inflammatory, anti-microbial, hypolipidemic, cardioprotective, hepatoprotective, nephroprotective and analgesic properties. In this study, the ethyl acetate (EtOAc) and butanol parts of Brassica rapa were first revealed with inhibitory effects on alpha-glucosidase, whereas the water part was inactive. Subsequent bioassay-guided isolation on the EtOAc and butanol parts yielded 12 compounds, involving three indole derivatives, indole-3-acetonitrile (1) 4-methoxyindole-3-acetonitrile (2) and indole-3-aldehyde (3) two flavonoids, liquiritin (4) and licochalcone A (5) two phenylpropanoids, sinapic acid (6) and caffeic acid (7) two phenylethanol glycosides, 2-phenylethyl beta-glucopyranoside (8) and salidroside (9) and three other compounds, syringic acid (10) adenosine (11) and (3 beta, 20E)-ergosta-5, 20 (22)-dien-3-ol (12) Licochalcone A (5) and caffeic acid (7) showed alpha-glucosidase inhibitory activity with IC50 values of 62.4 +/- 8.0 mu M and 162.6 +/- 3.2 mu M, comparable to the positive control, acarbose (IC50 = 142 +/- 0.02 mu M). Docking study suggested that licochalcone A (5) could well align in the active site of alpha-glucosidase (docking score = -52.88) by forming hydrogen bonds (Gln1372, Asp1420, Gln1372, Arg1510), hydrophobic effects (Tyr1251, Tyr1251, Trp1355, Phe1560, Ile1587, Trp1355, Phe1559, Phe1559) and pi-pi stacking interaction (Trp1355). This study provides valuable information for turnip as a new resource in searching anti-diabetic candidates.
C1 [Paul, Swastika; Zhang, Xuemei; Geng, Changan] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China.
   [Yang, Yongping] Chinese Acad Sci, Inst Tibetan Plateau Res Kunming, Kunming Inst Bot, Key Lab Biodivers & Biogeog, Kunming 650201, Yunnan, Peoples R China.
   [Paul, Swastika] Univ Chinese Acad Sci, Beijing 100049, Peoples R China.
C3 Chinese Academy of Sciences; Kunming Institute of Botany, CAS; Chinese
   Academy of Sciences; Kunming Institute of Botany, CAS; Chinese Academy
   of Sciences; University of Chinese Academy of Sciences, CAS
RP Geng, CA (corresponding author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China.
EM gengchangan@mail.kib.ac.cn
RI Yang, Yongping/NCV-0659-2025; Geng, Changan/GPS-5578-2022
OI Geng, Changan/0000-0001-9834-0756
FU Yunnan Science Fund for Excellent Young Scholars; National Natural
   Science Foundation of China [81773612]; Youth Innovation Promotion
   Association, CAS [2013252]; Reserve Talents of Young and Middle-aged
   Academic and Technical Leaders in Yunnan Province
FX This work was supported by the Yunnan Science Fund for Excellent Young
   Scholars, the National Natural Science Foundation of China (81773612),
   the Youth Innovation Promotion Association, CAS (2013252), and the
   Reserve Talents of Young and Middle-aged Academic and Technical Leaders
   in Yunnan Province.
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NR 27
TC 5
Z9 7
U1 4
U2 39
PU TECH SCIENCE PRESS
PI HENDERSON
PA 871 CORONADO CENTER DR, SUTE 200, HENDERSON, NV 89052 USA
SN 1851-5657
J9 PHYTON-INT J EXP BOT
JI Phyton-Int. J. Exp. Bot.
PY 2020
VL 89
IS 1
BP 131
EP 136
DI 10.32604/phyton.2020.08328
PG 6
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences
GA KU5TP
UT WOS:000519775600013
OA gold
DA 2026-05-27
ER

PT J
AU Xu, CL
   Liang, CH
   Sun, WX
   Chen, JD
   Chen, XH
AF Xu, Chongli
   Liang, Caihong
   Sun, Weixin
   Chen, Jiandong
   Chen, Xiaohu
TI Glycyrrhizic acid ameliorates myocardial ischemic injury by the
   regulation of inflammation and oxidative state
SO DRUG DESIGN DEVELOPMENT AND THERAPY
LA English
DT Article
DE glycyrrhizic acid; myocardial ischemia; Nrf-2/HO-1; oxidative stress;
   inflammation
ID HEART-DISEASE; REPERFUSION; SALIDROSIDE; RATS; PROTECTS
AB Background: Glycyrrhizic acid (GA), a bioactive triterpenoid saponin isolated from the roots of licorice plants (Glycyrrhiza glabra), has been shown to exert a variety of pharmacological activities and is considered to have potential therapeutic applications. The purpose of the present study was to investigate the cardioprotective effect of GA on myocardial ischemia (MI) injury rats induced by isoproterenol (ISO), and explore the potential mechanisms underlying these effects.
   Materials and methods: The rats were randomized into five groups: control, ISO, ISO+diltiazem (10 mg/kg), ISO+GA (10 mg/kg), and ISO+GA (20 mg/kg). Electrocardiogram and histopathological examination were performed. Markers of cardiac marker enzymes (creatine kinase-MB, lactate dehydrogenase), oxidative stress (superoxide dismutase, malondialdehyde [MDA]), and inflammation (TNF-alpha, IL-1 beta, and IL-6) were also measured in each group. Proteins involved in NF-kappa B and Nrf-2/HO-1 pathway were detected by Western blot.
   Results: GA decreased the ST elevation induced by MI, decreased serum levels of creatine kinase, lactate dehydrogenase, malondialdehyde, IL-6, IL-1 beta, and TNF-alpha, and increased serum superoxide dismutase and malondialdehyde activities. Furthermore, GA increased the protein levels of Nrf-2 and HO-1 and downregulated the phosphorylation of I kappa B, and NF-kappa B p65 in ISO-induced MI.
   Conclusion: These observations indicated that GA has cardioprotective effects against MI, and these effects might be related to the activation of Nrf-2/HO-1 and inhibition of NF-kappa B signaling pathway in the myocardium.
C1 [Xu, Chongli] Nanjing Univ Chinese Med, Nanjing 210029, Jiangsu, Peoples R China.
   [Xu, Chongli; Liang, Caihong] Jiangnin Hosp Nanjing, Nanjing 211100, Jiangsu, Peoples R China.
   [Sun, Weixin; Chen, Jiandong; Chen, Xiaohu] Nanjing Univ Chinese Med, Affiliated Hosp, Nanjing 210023, Jiangsu, Peoples R China.
C3 Nanjing University of Chinese Medicine; Nanjing University of Chinese
   Medicine
RP Chen, XH (corresponding author), Nanjing Univ Chinese Med, 138 Xianlin Ave, Nanjing 210023, Jiangsu, Peoples R China.
EM xhchennj@tom.com
RI chen, jiandong/ABB-6523-2021
FU Priority Academic Program Development of Jiangsu Higher Education
   Institutions (PAPD)
FX The study was supported by the Priority Academic Program Development of
   Jiangsu Higher Education Institutions (PAPD).
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NR 29
TC 53
Z9 68
U1 1
U2 15
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1177-8881
J9 DRUG DES DEV THER
JI Drug Des. Dev. Ther.
PY 2018
VL 12
BP 1311
EP 1319
DI 10.2147/DDDT.S165225
PG 9
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GH2AN
UT WOS:000433204000002
PM 29849452
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhao, YM
   Xiao, XR
   Tang, JD
   Wang, XQ
   Wu, C
   Qiao, L
AF Zhao, Yimei
   Xiao, Xinrui
   Tang, Jiadai
   Wang, Xueqiu
   Wu, Cheng
   Qiao, Lu
TI Microbial-Metabolite Interactions Underlying Quality Differences Between
   Green and Red Citrus Reticulata "Chachi" peel
SO JOURNAL OF FOOD SCIENCE
LA English
DT Article
DE antioxidant activity; CRC; differential metabolites; microbial
   community; non-targeted metabolomics
AB By using non-targeted metabolomics technology and high-throughput sequencing methods, the differences in metabolites between the green and red Citrus reticulata "Chachi" peels (CRCP), and their associations with microbial communities were systematically analyzed. Combined with physicochemical indicators (browning degree, total flavonoid content, antioxidant capacity), the material basis of their quality and functional components was explored. The results showed that the total flavonoid content (21.89 mg/g) and the antioxidant indicators (ABTS, FRAP) in green CRCP were significantly higher than those in red CRCP (P < 0.05), while there was no significant difference in browning degree. Metabolomics analysis showed that a total of 1,322 differential metabolites were identified in green and red CRCP. A total of 723 metabolites in green CRCP were significantly up regulated (similar to 54.70%) (p < 0.05), including active components such as lariciresinol, ginsenoside Rb1, and salidroside, with potential anti-diabetic, anti-tumor and anti-depression properties, respectively. Correlation analysis of physicochemical indicators and metabolites indicated that antioxidant capacity was positively correlated with most metabolites (83.56%), and the accumulation of core metabolites such as dodecatetraene and genipin was synergistically regulated by FRAP, ABTS, and total flavonoids. The abundance of fungi such as Aspergillus spp. In green CRCP was relatively high, which was positively correlated with the total flavonoid and antioxidant indicators, driving the synthesis of flavonoids. Cladosporium in red CRCP was negatively correlated with metabolites, and bacteria were negatively correlated with antioxidant indicators. This study reveals the advantages of green CRCP in antioxidant activity, and provides a theoretical basis at the metabolite and microbial levels.
C1 [Zhao, Yimei; Xiao, Xinrui; Tang, Jiadai; Wang, Xueqiu] Moutai Inst, Dept Liquor Engn, Renhuai, Peoples R China.
   [Zhao, Yimei] Northwest A&F Univ, Coll Enol, Yangling, Peoples R China.
   [Tang, Jiadai; Qiao, Lu] Guizhou Univ, Coll Resources & Environm Engn, Guiyang, Peoples R China.
   [Wu, Cheng] Guizhou Xijiu Co Ltd, Technol Ctr, Zunyi, Peoples R China.
C3 Moutai Institute; Northwest A&F University - China; Guizhou University
RP Tang, JD (corresponding author), Moutai Inst, Dept Liquor Engn, Renhuai, Peoples R China.; Tang, JD; Qiao, L (corresponding author), Guizhou Univ, Coll Resources & Environm Engn, Guiyang, Peoples R China.
EM tangjiadai1108@163.com; gs.lqiao24@gzu.edu.cn
FU Zunyi Science and Technology Plan Projects
FX This work was financially supported by the Undergraduate Innovation and
   Entrepreneurship Training Project of China (Grant No.: 2024146250701),
   Guizhou Provincial Basic Research Program (Natural Science) Youth
   Guidance Project (Grant No.: QianKeHeJiChu-QN[20241200), Zunyi Science
   and Technology Plan Projects (No.: [20241375), and Zunyi Science and
   Technology Plan Projects (No.: [20231109).
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NR 45
TC 0
Z9 0
U1 8
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-1147
EI 1750-3841
J9 J FOOD SCI
JI J. Food Sci.
PD SEP
PY 2025
VL 90
IS 9
AR e70540
DI 10.1111/1750-3841.70540
PG 14
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 8CL5M
UT WOS:001585366900004
PM 40932179
DA 2026-05-27
ER

PT J
AU Chang, QY
   Liu, X
   Li, Y
   Zhao, W
   Tang, ZH
   Liu, Y
   Mu, LQ
AF Chang, Qiuyang
   Liu, Xu
   Li, Yi
   Zhao, Wen
   Tang, Zhonghua
   Liu, Yang
   Mu, Liqiang
TI Morphological Variation and Spatial Metabolic Variations in Rhodiola
   sachalinensis A.Bor. in Different Natural Distribution Areas
SO PLANTS-BASEL
LA English
DT Article
DE morphological variation; metabolic characteristics; Rhodiola
   sachalinensis A.Boriss.; GS-MS
ID GENETIC DIVERSITY; AMINO-ACIDS; SALIDROSIDE; TRAITS
AB To explore the genetic diversity and metabolic characteristics among different locations of wild Rhodiola sachalinensis A.Boriss., we collected specimens from two sites (DHL: 128 degrees 23 ' 06 '' N, 44 degrees 26 ' 31 '' E; FHS: 127 degrees 59 ' 26 '' N, 44 degrees 7 ' 22 '' E) and measured various biological traits, such as leaf length, leaf width, and plant height. We conducted metabolic analyses to investigate variations among different plant parts. Our study revealed that while the various plant parts of wild R. sachalinensis A.Boriss. from these two locations showed overall numerical similarities, they exhibited relatively high coefficients of variation in traits such as leaf length, leaf width, plant height, and stem thickness. Furthermore, utilizing gas chromatography-mass spectrometry (GS-MS), we detected significant differences in primary metabolites among different plant parts from both locations. Using orthogonal partial least squares discriminant analysis (OPLS-DA), we identified 42 and 34 different metabolites in the roots, stems, and leaves of plants from the DHL site and 62 and 50 different metabolites in the roots, stems, and leaves of plants from the FHS site. Metabolic heatmaps suggested that sugar metabolism was more active in the roots compared to other plant parts. Through KEGG pathway analysis, we determined that the primary metabolic differences were concentrated in the citric acid cycle (TCA cycle) and amino acid metabolism, including pathways related to glycine, serine, and threonine metabolism, as well as alanine, aspartate, and glutamate metabolism. These findings indicate that wild R. sachalinensis A.Boriss. plants from different locations not only exhibit significant variations in biological traits but also demonstrate notable distinctions in the distribution of primary metabolites among different plant parts.
C1 [Chang, Qiuyang; Liu, Xu; Li, Yi; Zhao, Wen; Mu, Liqiang] Northeast Forestry Univ, Sch Forestry, Harbin 150040, Peoples R China.
   [Tang, Zhonghua] Northeast Forestry Univ, Coll Chem Chem Engn & Resource Utilizat, Harbin 150040, Peoples R China.
   [Liu, Yang] Heilongjiang Univ, Engn Res Ctr Agr Microbiol Technol, Minist Educ, Harbin 150500, Peoples R China.
C3 Northeast Forestry University - China; Northeast Forestry University -
   China; Heilongjiang University
RP Mu, LQ (corresponding author), Northeast Forestry Univ, Sch Forestry, Harbin 150040, Peoples R China.; Liu, Y (corresponding author), Heilongjiang Univ, Engn Res Ctr Agr Microbiol Technol, Minist Educ, Harbin 150500, Peoples R China.
EM liuxu19981209@nefu.edu.cn; tangzh@nefu.edu.cn; 2021103@hlju.edu.cn;
   mlq0417@163.com
RI Tang, Zhonghua/GZA-6217-2022
OI Tang, Zhonghua/0000-0003-3278-5861
FU National Science and Technology Basic Resources Investigation Project
FX No Statement Available
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NR 40
TC 0
Z9 0
U1 2
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2223-7747
J9 PLANTS-BASEL
JI Plants-Basel
PD FEB
PY 2024
VL 13
IS 4
AR 467
DI 10.3390/plants13040467
PG 16
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences
GA JW2H7
UT WOS:001176128800001
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Chen, TF
   Lv, DF
   Rong, BH
   Shi, ZZ
   Li, XL
   Jia, ZC
   Gao, ZW
   Zhong, CF
AF Chen, Tengfei
   Lv, Dongfang
   Rong, Baohai
   Shi, Zhuozhuo
   Li, Xiaolin
   Jia, Zhichao
   Gao, Zhaowang
   Zhong, Chongfu
TI Phytochemical characterization and therapeutic mechanism of Xialiqi
   capsule on benign prostatic hyperplasia
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Article
DE Xialiqi capsule; Benign prostatic hyperplasia; Phytochemical
   characterization; Therapeutic mechanism; Network analysis;
   Pharmacological experiments
ID OXIDATIVE STRESS; PHARMACOLOGY; MEDICATIONS; EXPRESSION; GENES
AB Benign prostatic hyperplasia (BPH) is a common urological condition prevalent in elderly men. Xialiqi capsule (XLQC), a traditional Chinese patent medicine, is widely used to manage BPH. However, the precise mechanisms underlying XLQC's effectiveness in treating BPH are not well-understood. We aimed to investigate the phytochemical composition and therapeutic mechanisms of XLQC in the treatment of BPH. We conducted a comprehensive investigation that integrated high-performance liquid chromatography-mass spectrometry (LC-MS/MS), network pharmacological analysis, and animal experimental validation to explore potential pharmacodynamic compounds and mechanisms of action for XLQC in BPH treatment. In this study, a total of 12 components targeting eight molecular targets were identified; the major components included Danshensu, salidroside, 6-Acetylcodeine, azelaic acid, and berberine. The targets were CASP3, MMP9, PTGS2, IL6, ESR1, ERBB2, HIF1 A, and epidermal growth factor receptor (EGFR). Enrichment analysis revealed that the molecular targets are mainly through calcium signaling pathway, endocrine resistance, steroid hormone biosynthesis, HIF- 1 signaling pathway, and estrogen signaling pathway regulates cell proliferation and apoptosis as well as oxidative stress response. In vivo animal experiments demonstrated that XLQC effectively inhibited oxidative stress (OS) and cell proliferation by reducing malondialdehyde (MDA), increasing superoxide dismutase (SOD), and inhibiting the expression of Ki- 67 in prostate tissue, thereby improving prostate tissue morphology and reducing prostate index. XLQC can inhibit oxidative stress and cell proliferation, improve the morphology of prostate tissue, reduce the prostate index, and have therapeutic effects on BPH through multi-component, multi-target, and multi-pathway effects.
C1 [Chen, Tengfei; Rong, Baohai; Shi, Zhuozhuo; Gao, Zhaowang; Zhong, Chongfu] Shandong Univ Tradit Chinese Med, Affiliated Hosp, 16369,Jingshi Rd, Jinan, Shandong, Peoples R China.
   [Lv, Dongfang; Li, Xiaolin; Jia, Zhichao] Shandong Univ Tradit Chinese Med, Coll Clin Med 1, Jinan, Peoples R China.
C3 Shandong University of Traditional Chinese Medicine; Shandong University
   of Traditional Chinese Medicine
RP Zhong, CF (corresponding author), Shandong Univ Tradit Chinese Med, Affiliated Hosp, 16369,Jingshi Rd, Jinan, Shandong, Peoples R China.
EM zhongcf212@163.com
RI Chen, Tengfei/KPB-6967-2024
OI Chen, Tengfei/0009-0004-1572-3276
FU Horizontal Project of The Affiliated Hospital of Shandong University of
   Traditional Chinese Medicine [H20220809]
FX This study was supported by the Horizontal Project of The Affiliated
   Hospital of Shandong University of Traditional Chinese Medicine
   (H20220809).
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NR 57
TC 0
Z9 0
U1 2
U2 6
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0028-1298
EI 1432-1912
J9 N-S ARCH PHARMACOL
JI Naunyn-Schmiedebergs Arch. Pharmacol.
PD OCT
PY 2025
VL 398
IS 10
BP 13769
EP 13783
DI 10.1007/s00210-025-04108-9
EA APR 2025
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 8SN7X
UT WOS:001465476300001
PM 40223034
DA 2026-05-27
ER

PT J
AU Ejiohuo, O
   Bajia, D
   Pawlak, J
   Szczepankiewicz, A
AF Ejiohuo, Ovinuchi
   Bajia, Donald
   Pawlak, Joanna
   Szczepankiewicz, Aleksandra
TI In silico identification of novel ligands targeting stress-related human
   FKBP5 protein in mental disorders
SO PLOS ONE
LA English
DT Article
ID RECEPTOR ROR-ALPHA; CURCUMIN; RUSCOGENIN; PHARMACOLOGY; EXPRESSION;
   FK506; NEORUSCOGENIN; INVOLVEMENT; ASCOMYCIN; MODEL
AB FK506-binding protein 51 (FKBP51 or FKBP5) serves as a crucial stress modulator implicated in mental disorders, presenting a potential target for intervention. Inhibitors like SAFit2, rapamycin, and tacrolimus exhibit promising interactions with this protein. Despite these advances, challenges persist in diversifying FKBP5 ligands, prompting further exploration of interaction partners. Hence, this study aims to identify other potential ligands. Employing molecular docking, we generated complexes with various ligands (rapamycin, tacrolimus, SAFit2-Selective antagonist of FKBP51 by induced fit, ascomycin, pimecrolimus, rosavin, salidroside, curcumin, apigenin, uvaricin, ruscogenin, neoruscogenin, pumicalagin, castalagin, and grandinin). We identified the top 3 best ligands, of which ruscogenin and neoruscogenin had notable abilities to cross the blood-brain barrier and have high gastrointestinal absorption, like curcumin. Toxicity predictions show ruscogenin and neoruscogenin to be the least toxic based on oral toxicity classification (Class VI). Tyrosine (Tyr113) formed consistent interactions with all ligands in the complex, reinforcing their potential and involvement in stress modulation. Molecular dynamic (MD) simulation validated strong interactions between our three key ligands and FKBP5 protein and provided an understanding of the stability of the complex. The binding free energy (Delta G) of the best ligands (based on pharmacological properties) from MD simulation analysis is -31.78 kcal/mol for neoruscogenin, -30.41 kcal/mol for ruscogenin, and -27.6 kcal/mol for curcumin. These molecules, therefore, can serve as therapeutic molecules or biomarkers for research in stress-impacted mental disorders. While offering therapeutic implications for mental disorders by attenuating stress impact, it is crucial to emphasize that these ligands' transition to clinical applications necessitates extensive experimental research, including clinical trials, to unravel the intricate molecular and neural pathways involved in these interactions.
C1 [Ejiohuo, Ovinuchi; Pawlak, Joanna] Poznan Univ Med Sci, Dept Psychiat Genet, Poznan, Poland.
   [Ejiohuo, Ovinuchi; Szczepankiewicz, Aleksandra] Poznan Univ Med Sci, Mol & Cell Biol Unit, Poznan, Poland.
   [Ejiohuo, Ovinuchi; Bajia, Donald] Poznan Univ Med Sci, Doctoral Sch, Poznan, Poland.
   [Bajia, Donald] Poznan Univ Med Sci, Dept Pediat Oncol Hematol & Transplantol, Poznan, Poland.
C3 Poznan University of Medical Sciences; Poznan University of Medical
   Sciences; Poznan University of Medical Sciences; Poznan University of
   Medical Sciences
RP Ejiohuo, O (corresponding author), Poznan Univ Med Sci, Dept Psychiat Genet, Poznan, Poland.; Ejiohuo, O (corresponding author), Poznan Univ Med Sci, Mol & Cell Biol Unit, Poznan, Poland.; Ejiohuo, O (corresponding author), Poznan Univ Med Sci, Doctoral Sch, Poznan, Poland.
EM ovinuchi.ejiohuo@gmail.com
RI Ejiohuo, Ovinuchi Prince/KRQ-0525-2024; Bajia, Donald
   Samdumu/JUF-5350-2023
OI Ejiohuo, Ovinuchi Prince/0000-0003-2153-7205; Bajia, Donald
   Samdumu/0000-0002-5066-1398
FU Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu; Poznan
   University of Medical Sciences
FX The authors acknowledge the Poznan University of Medical Sciences for
   their support in promoting research and internationalisation.
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NR 133
TC 5
Z9 5
U1 0
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
EI 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 17
PY 2025
VL 20
IS 3
AR e0320017
DI 10.1371/journal.pone.0320017
PG 32
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 0IR6N
UT WOS:001448306400017
PM 40096182
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Thu, OK
   Nilsen, OG
   Hellum, B
AF Thu, Ole Kristian
   Nilsen, Odd Georg
   Hellum, Bent
TI In vitro inhibition of cytochrome P-450 activities and
   quantification of constituents in a selection of commercial Rhodiola
   rosea products
SO PHARMACEUTICAL BIOLOGY
LA English
DT Article
DE CYP inhibition; IC50; golden root; quality
ID BIOACTIVE COMPOUNDS; DRUG-INTERACTIONS; EXTRACT; L.; ROOTS; GLYCOSIDES;
   QUALITY; ETHANOL; CYP3A4; SHR-5
AB Context: Rhodiola rosea L. (Crassulaceae) products are popular natural remedies with a worldwide distribution. Recent studies have revealed potent CYP inhibition by R. rosea extracts both in vitro and in vivo, but information on in vitro CYP inhibition by commercial products are lacking. Variations in commercial R. rosea product quality have also been published.
   Objective: This study evaluates the variation of in vitro CYP inhibition potential and product quality of six commercially available R. rosea products.
   Materials and methods: Human CYPs isolated from baculovirus-infected cell system were incubated with testosterone (CYP3A4), dextromethorphan (CYP2D6) or phenacetin (CYP1A2). Positive CYP inhibitors ketoconazole (CYP3A4), quinidine (CYP2D6) and beta-naphtoflavone (CYP1A2) were used as controls. Quantification of rosavin, rosarin, rosin, tyrosol and salidroside were used to evaluate R. rosea content.
   Results: IC50 values ranged from 7.2-106.6 mu g/mL for CYP3A4, 13.0-186.1 mu g/mL for 2D6 and 10.7-116.0 mu g/mL for 1A2. The tincture formulation of R. rosea was the strongest inhibitor giving the lowest IC50 values of 7.2 +/- 0.7, 13 +/- 1.7 and 10.7 +/- 5.6 mu g/mL, respectively. CYP3A4 was significantly more inhibited by the different products than CYP1A2 (p<.05). One of the six products did not contain any rosavin, rosarin or rosin and is not a R. rosea product. Constituent concentrations were not linked to enzyme inhibition.
   Discussion and conclusion: The present results show a large variation in inhibitory potential between the products. Several of the products demonstrate similar inhibition levels as the product Arctic Root already proven to inhibit CYP enzyme activity in man.
C1 [Thu, Ole Kristian; Nilsen, Odd Georg; Hellum, Bent] Norwegian Univ Sci & Technol NTNU, Dept Canc Res & Mol Med, Fac Med, Trondheim 7006, Norway.
C3 Norwegian University of Science & Technology (NTNU)
RP Thu, OK (corresponding author), Norwegian Univ Sci & Technol NTNU, St Olav Univ Hosp, Fac Med, Gastro Ctr,Dept Canc Res & Mol Med, Prinsesse Kristinasgate 1, N-7006 Trondheim, Norway.
EM ole.k.thu@ntnu.no
OI Thu, Ole Kristian Forstrønen/0000-0003-1422-6062
CR [Anonymous], 2018, Bioanalytical Method Validation: Guidance for Industry
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NR 43
TC 18
Z9 20
U1 0
U2 20
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1388-0209
EI 1744-5116
J9 PHARM BIOL
JI Pharm. Biol.
PD DEC
PY 2016
VL 54
IS 12
BP 3249
EP 3256
DI 10.1080/13880209.2016.1223145
PG 8
WC Plant Sciences; Medical Laboratory Technology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Medical Laboratory Technology; Pharmacology & Pharmacy
GA EE2VN
UT WOS:000389443300060
PM 27572116
DA 2026-05-27
ER

PT J
AU Song, PP
   Xia, JF
   Rezeng, CD
   Tong, L
   Tang, W
AF Song, Peipei
   Xia, Jufeng
   Rezeng, Caidan
   Tong, Li
   Tang, Wei
TI Traditional, complementary, and alternative medicine: Focusing on
   research into traditional Tibetan medicine in China
SO BIOSCIENCE TRENDS
LA English
DT Article
DE Minority medicine; traditional medicine; evidence-based medicine;
   components of traditional Tibetan medicines; active ingredient; quality
   standards
ID PERFORMANCE LIQUID-CHROMATOGRAPHY; INDUCED STATUS EPILEPTICUS;
   HYPECOUM-ERECTUM EXTRACT; ACONITUM-CARMICHAELI; MULTICOMPONENT
   QUANTITATION; ISOQUINOLINE ALKALOIDS; SALIDROSIDE PROTECTS; ANTIOXIDANT
   ACTIVITY; TERMINALIA-CHEBULA; CELLS
AB As a form of traditional, complementary, and alternative medicine (TCAM), traditional Tibetan medicine has developed into a mainstay of medical care in Tibet and has spread from there to China and then to the rest of the world. Thus far, research on traditional Tibetan medicine has focused on the study of the plant and animal sources of traditional medicines, study of the histology of those plants and animals, chemical analysis of traditional medicines, pharmacological study of those medicines, and evaluation of the clinical efficacy of those medicines. A number of papers on traditional Tibetan medicines have been published, providing some evidence of the efficacy of traditional Tibetan medicine. However, many traditional Tibetan medicines have unknown active ingredients, hampering the establishment of drug quality standards, the development of new medicines, commercial production of medicines, and market availability of those medicines. Traditional Tibetan medicine must take several steps to modernize and spread to the rest of the world: the pharmacodynamics of traditional Tibetan medicines need to be determined, the clinical efficacy of those medicines needs to be verified, criteria to evaluate the efficacy of those medicines need to be established in order to guide their clinical use, and efficacious medicines need to be acknowledged by the pharmaceutical market. The components of traditional Tibetan medicine should be studied, traditional Tibetan medicines should be screened for their active ingredients, and techniques should be devised to prepare and manufacture those medicines.
C1 [Song, Peipei] Univ Tokyo, Grad Sch Frontier Sci, Kashiwa, Chiba, Japan.
   [Xia, Jufeng; Tang, Wei] Univ Tokyo, Grad Sch Med, Tokyo, Japan.
   [Rezeng, Caidan; Tong, Li] Qinghai Univ, Coll Med, Res Ctr Chinese & Tibetan Med, 16 Kunlun Rd, Xining 810001, Qinghai, Peoples R China.
C3 University of Tokyo; University of Tokyo; Qinghai University
RP Tong, L (corresponding author), Qinghai Univ, Coll Med, Res Ctr Chinese & Tibetan Med, 16 Kunlun Rd, Xining 810001, Qinghai, Peoples R China.
EM qhdx2011@126.com
RI Xia, Jufeng/AAW-2643-2020
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NR 76
TC 15
Z9 17
U1 9
U2 98
PU IRCA-BSSA
PI TOKYO
PA PEARL CITY KOISHIKAWA 603, 2-4-5 KASUGA, BUNKYO-KU, TOKYO, 112-0003,
   JAPAN
SN 1881-7815
EI 1881-7823
J9 BIOSCI TRENDS
JI BioSci. Trends
PD JUN
PY 2016
VL 10
IS 3
BP 163
EP 170
DI 10.5582/bst.2016.01105
PG 8
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA DQ5OC
UT WOS:000379253700001
PM 27301588
OA Bronze
DA 2026-05-27
ER

PT J
AU Hu, GS
   Jia, JM
   Hur, YJ
   Chung, YS
   Lee, JH
   Yun, DJ
   Chung, WS
   Yi, GH
   Kim, TH
   Kim, DH
AF Hu, Gao Sheng
   Jia, Jing Ming
   Hur, Yeon Jae
   Chung, Young Soo
   Lee, Jai Heon
   Yun, Dae Jin
   Chung, Woo Sik
   Yi, Gi Hwan
   Kim, Tae Ho
   Kim, Doh Hoon
TI Molecular characterization of phenylalanine ammonia lyase gene from
   Cistanche deserticola
SO MOLECULAR BIOLOGY REPORTS
LA English
DT Article
DE Cistanche deserticola; Orobanchaceae; Roucongrong; Gene cloning and
   characterization; Phenylalanine ammonia lyase; Inhibitory effects
ID PHENYLETHANOID GLYCOSIDES; 1-METHYL-4-PHENYLPYRIDINIUM ION;
   2-AMINOINDAN-2-PHOSPHONIC ACID; SUSPENSION-CULTURES; TYROSINE;
   ACCUMULATION; APOPTOSIS; FAMILY; GROWTH; HERBA
AB We cloned the gene, CdPAL1, from Cistanche deserticola callus using RACE PCR with degenerate primers that were designed based on a multiple sequence alignment of known PAL genes from other plant species. The gene shows high homology to other known PAL genes registered in GenBank. The recombinant protein exhibited Michaelis-Menten kinetics with a K (m) of 0.1013 mM, V (max) of 4.858 mu mol min(-1), K (cat) of 3.36 S-1, and K (cat)/K (m) is 33,168 M-1 S-1. The enzyme had an optimal pH of 8.5 and an activation energy of 38.92 kJ mol(-1) when l-Phenylalanine was used as a substrate; l-tyrosine cannot be used as substrate for this protein. The optimal temperature was 55A degrees C, and the thermal stability results showed that, after a treatment at 70A degrees C for 20 min, the protein retained 87% activity, while a treatment at 75A degrees C for 20 min resulted in a loss of over 85% of the enzyme activity. Treatment with heavy metal ions (Hg2+, Pb2+, and Zn2+) showed remarkable inhibitory effects. Among the intermediates from the lignin (cinnamyl alcohol, cinnamyl aldehyde, coniferyl aldehyde, coniferyl alcohol), phenylpropanoid (cinnamic acid, coumaric acid, caffeic acid, and chlorogenic acid) and phenylethanoid (tyrosol and salidroside) biosynthetic pathways, only cinnamic acid showed strong inhibitory effects against CdPAL1 activity with a K (i) of 8 mu M. Competitive inhibitor AIP exhibited potent inhibition with K (i) = 0.056 mu M.
C1 [Hu, Gao Sheng; Hur, Yeon Jae; Chung, Young Soo; Lee, Jai Heon; Kim, Doh Hoon] Dong A Univ, Coll Life Sci & Nat Resources, Pusan 604714, South Korea.
   [Jia, Jing Ming] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China.
   [Jia, Jing Ming; Kim, Doh Hoon] Shenyang Pharmaceut Univ, Joint Lab, Shenyang 110016, Peoples R China.
   [Jia, Jing Ming; Kim, Doh Hoon] Dong A Univ, Shenyang 110016, Peoples R China.
   [Yun, Dae Jin; Chung, Woo Sik] Gyeongsang Natl Univ, Div Appl Life Sci, Jinju 660701, South Korea.
   [Yi, Gi Hwan] RDA, NICS, Dept Funct Crop, Funct Crop Resource Dev Div, Gyeong Nam 627803, South Korea.
   [Kim, Tae Ho] RDA, NAAS, Dept Agr Biotechnol, Genom Div, Suwon 441707, South Korea.
C3 Dong A University; Shenyang Pharmaceutical University; Shenyang
   Pharmaceutical University; Gyeongsang National University; Rural
   Development Administration (RDA), Republic of Korea; National Institute
   of Crop Science; Rural Development Administration (RDA), Republic of
   Korea
RP Kim, DH (corresponding author), Dong A Univ, Coll Life Sci & Nat Resources, Pusan 604714, South Korea.
EM dhkim@dau.ac.kr
OI Yun, Dae-Jin/0000-0002-3638-6043
FU Dong-A University
FX This study was supported by research funds from Dong-A University. We
   would like to express our appreciation to Dr. Jerry Zon from the
   Institute of Organic and Physical Chemistry at the Technical University
   Wroclaw, Holland, who provided us AIP for our determination of its
   inhibitory effects on CdPAL1 activity.
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NR 24
TC 33
Z9 42
U1 3
U2 41
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0301-4851
EI 1573-4978
J9 MOL BIOL REP
JI Mol. Biol. Rep.
PD AUG
PY 2011
VL 38
IS 6
BP 3741
EP 3750
DI 10.1007/s11033-010-0489-0
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 777WW
UT WOS:000291656800018
PM 21104014
DA 2026-05-27
ER

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   Saimaiti, Adila
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   Li, Hua-Bin
   Li, Sha
TI Effects of Fermentation with Kombucha Symbiotic Culture of Bacteria and
   Yeasts on Antioxidant Activities, Bioactive Compounds and Sensory
   Indicators of Rhodiola rosea and Salvia miltiorrhiza
   Beverages
SO MOLECULES
LA English
DT Article
DE kombucha; beverage; Rhodiola rosea; Salvia miltiorrhiza; fermentation;
   antioxidant activity; polyphenols
AB Kombucha is a well-known fermented beverage traditionally made from black tea infusion. Recent studies have focused on finding alternative materials to create novel kombucha beverages with various health benefits. In this study, we prepared and evaluated two novel kombucha beverages using Rhodiola rosea and Salvia miltiorrhiza as materials. The effects of fermentation with the residue of these plants on the kombucha were also investigated. The antioxidant activities, total phenolic contents, and concentrations of the bioactive compounds of the kombucha beverages were determined by the Trolox equivalent antioxidant capacity test, ferric-reducing antioxidant power test, Folin-Ciocalteu method, and high-performance liquid chromatography, respectively. The results revealed that the kombucha beverages made with Rhodiola rosea and Salvia miltiorrhiza had strong antioxidant capacities and abundant phenolic contents. Additionally, the kombucha fermented with Rhodiola rosea residue had higher FRAP, TEAC and TPC values than that fermented without residue. On the other hand, the Salvia miltiorrhiza kombucha fermented with residue had similar FRAP and TEAC values but lower TPC values compared to that fermented without residue. The correlation analysis showed that gallic acid, salidroside, and tyrosol were responsible for the antioxidant abilities and total phenolic contents of the Rhodiola rosea kombucha, and salvianolic acid A and salvianolic acid B contributed to the antioxidant abilities of the Salvia miltiorrhiza kombucha. Furthermore, the kombucha fermented with Rhodiola rosea residue had the highest sensory scores among the kombucha beverages studied. These findings suggest that Rhodiola rosea and Salvia miltiorrhiza are suitable for making novel kombucha beverages with strong antioxidant abilities and abundant phenolic contents, which can be used in preventing and managing oxidative stress-related diseases.
C1 [Cheng, Jin; Zhou, Dan-Dan; Xiong, Ruo-Gu; Wu, Si-Xia; Huang, Si-Yu; Saimaiti, Adila; Li, Hua-Bin] Sun Yat Sen Univ, Sch Publ Hlth, Dept Nutr, Guangdong Prov Key Lab Food Nutr & Hlth, Guangzhou 510080, Peoples R China.
   [Xu, Xiao-Yu; Tang, Guo-Yi] Univ Hong Kong, Li Ka Shing Fac Med, Sch Chinese Med, Hong Kong 999077, Peoples R China.
   [Li, Sha] Shanghai Jiao Tong Univ, Sch Publ Hlth, Sch Med, Shanghai 200025, Peoples R China.
C3 Sun Yat Sen University; University of Hong Kong; Shanghai Jiao Tong
   University
RP Li, HB (corresponding author), Sun Yat Sen Univ, Sch Publ Hlth, Dept Nutr, Guangdong Prov Key Lab Food Nutr & Hlth, Guangzhou 510080, Peoples R China.; Li, S (corresponding author), Shanghai Jiao Tong Univ, Sch Publ Hlth, Sch Med, Shanghai 200025, Peoples R China.
EM lihuabin@mail.sysu.edu.cn; lishaha@shsmu.edu.cn
RI Li, Sha/ABC-5264-2022; zhou, dandan/OUJ-6442-2025; Li,
   Hua-Bin/AEX-9846-2022
OI Xiong, Ruo-Gu/0000-0002-2978-0026; Li, Hua-Bin/0000-0003-2332-8554;
   TANG, Guoyi/0009-0004-4036-7082
FU Key Project of Guangdong Provincial Science and Technology Program; 
   [2014B020205002]
FX This research was funded by the Key Project of Guangdong Provincial
   Science and Technology Program (No. 2014B020205002).
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NR 40
TC 4
Z9 4
U1 10
U2 57
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD AUG
PY 2024
VL 29
IS 16
AR 3809
DI 10.3390/molecules29163809
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA F0I0P
UT WOS:001306732600001
PM 39202889
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Sawant, O
   Khan, T
AF Sawant, Omkar
   Khan, Tabassum
TI Management of periorbital hyperpigmentation: An overview of nature-based
   agents and alternative approaches
SO DERMATOLOGIC THERAPY
LA English
DT Review
DE caffeine pad; dihydrochalcone; melasma; periorbital hyperpigmentation;
   Q-switched ruby laser
ID TYROSINASE ACTIVITY; ACID; MELANOGENESIS; PIGMENTATION; EFFICACY;
   MELASMA; PHOTO
AB Periorbital hyperpigmentation (POH) is a common dermatological condition that presents as dark periorbital area beneath the lower eyelids, and it is commonly found in females belonging to the age group of 16 to 45 years. The data presented in this review include studies conducted on patients with a clinical/histological diagnosis of POH or melasma. Many diverse topical depigmenting agents comprising an array of naturally obtained actives such as arabinoxylans, a-arbutin, asiaticoside, azelaic acid, beta-carotene, boswellic acid, caffeine, chrysin, curcumin, cyanidin-3-glucoside, D-glucoronic acid, dihydrochalcone, dipalmitoyl-hydroxyprolene, fucoxanthin, genistein, glabridin, b-glucogallin, hyaluronic acid, lactic acid, lycopene, niacinamide, pycnogenol, retinol, salidroside, and xymenynic acid demonstrated significant benefits in the management of POH. An exhaustive literature search revealed that other techniques such as blepharoplasty, carboxytherapy, calcium hydroxylapatite fillers, tear trough implant, Q-switched ruby laser, medicated tattoo, fat transfer, micro-needling, chemical peels, nitrogen plasma skin regeneration, intense pulsed light, and radiofrequency have been evaluated and reported to be beneficial in the treatment of POH. The use of topical depigmenting agents is the most widely reported method in the clinical management of POH. Of these, alpha-arbutin, caffeine, cyanidin-3-glucoside, and dihydrochalcone are reported to exhibit significant benefits. Combination products containing a blend of actives are reported to be better than single active containing products. This review aims to provide a comprehensive perspective on the role of several topical actives in the modulation of melanin and tyrosinase biosynthesis pathway involved in the complex pathophysiology of POH. It also presents the advantages of combination products and other alternative therapies used in the management of POH.
C1 [Sawant, Omkar] SVKMs Dr Bhanuben Nanavati Coll Pharm, Dept Qual Assurance, Mumbai, Maharashtra, India.
   [Khan, Tabassum] SVKMs Dr Bhanuben Nanavati Coll Pharm, Dept Pharmaceut Chem & Qual Assurance, Mumbai, Maharashtra, India.
RP Khan, T (corresponding author), SVKMs Dr Bhanuben Nanavati Coll Pharm, Dept Pharmaceut Chem & Qual Assurance, Mumbai, Maharashtra, India.
EM tabassum.khan@bncp.ac.in
RI Sawant, Omkar/AAD-7620-2021
OI Sawant, Omkar/0000-0002-0152-4901; Khan, Tabassum
   Asif/0000-0002-3723-0833
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NR 44
TC 30
Z9 35
U1 1
U2 45
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1396-0296
EI 1529-8019
J9 DERMATOL THER
JI Dermatol. Ther.
PD JUL
PY 2020
VL 33
IS 4
AR e13717
DI 10.1111/dth.13717
EA JUL 2020
PG 14
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA NL4WM
UT WOS:000545494800001
PM 32472659
DA 2026-05-27
ER

PT J
AU Bi, HP
   Wang, S
   Zhou, W
   Zhuang, YB
   Liu, T
AF Bi, Huiping
   Wang, Shuai
   Zhou, Wei
   Zhuang, Yibin
   Liu, Tao
TI Producing Gram-Scale Unnatural Rosavin Analogues from Glucose by
   Engineered Escherichia coli
SO ACS SYNTHETIC BIOLOGY
LA English
DT Article
DE cinnamyl alcohol glycosides; Rhodiola rosea; rosavin analogues;
   glycosyltransferase; Escherichia coli
ID PHENYLPROPANOID GLYCOSIDES; CINNAMYL ALCOHOL; GLYCOSYLTRANSFERASES;
   BIOSYNTHESIS; METABOLISM
AB Cinnamyl alcohol glycosides (CAGs) are key active ingredients of the precious medicinal plant Rhodiola rosea L., which has diverse pharmacological activities. The quality of R. rosea extracts is standardized to the contents of rosavin, a cinnamyl alcohol disaccharide, along with salidroside. The supply of rosavin and analogues is limited by both the inefficiency of chemical synthesis methods and the shortage of natural resources. Herein, we achieved de novo synthesis of a series of rosavin analogues by engineered Escherichia coli strains. First, cinnamyl alcohol was synthesized by expression of phenylalanine ammonia-lyase (PAL), hydroxycinnamate:CoA ligase, and cinnamyl-CoA reductase in a phenylalanine high-producing strain. UGT73C5 from Arabidopsis thaliana and a sugar chain elongating glycosyltransferase from Catharanthus roseus, CaUGT3 sequentially catalyzed the formation of an unnatural cinnamyl alcohol diglucoside, named rosavin B. Then, these biosynthetic enzymes were transformed into a tyrosine high-producing strain, except that PAL was replaced by a tyrosine ammonia-lyase, and synthesis of mono- and diglucosides of p-coumaryl alcohol with sugars attached to aliphatic or phenolic hydroxyl position was achieved. Finally, fed-batch fermentation was conducted for the strain producing rosavin B, and the titer reached 4.7 g/L. Tri- and tetraglucosides of cinnamyl alcohol were also produced by fed-batch fermentation. In summary, seven rosavin analogues including six unnatural compounds were produced from glucose by microorganisms. This work expanded the structural diversity of CAGs, which holds promise to discover new analogues with improved pharmaceutical properties. The study also paves the way for producing CAGs in a sustainable and cheap way.
C1 [Bi, Huiping; Wang, Shuai; Zhou, Wei; Zhuang, Yibin; Liu, Tao] Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Tianjin 300308, Peoples R China.
   [Bi, Huiping; Wang, Shuai; Zhou, Wei; Zhuang, Yibin; Liu, Tao] Chinese Acad Sci, Key Lab Syst Microbial Biotechnol, Tianjin 300308, Peoples R China.
   [Wang, Shuai] Tianjin Univ Sci & Technol, Tianjin 300457, Peoples R China.
C3 Chinese Academy of Sciences; Tianjin Institute of Industrial
   Biotechnology, CAS; Chinese Academy of Sciences; Tianjin University of
   Science & Technology
RP Liu, T (corresponding author), Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Tianjin 300308, Peoples R China.; Liu, T (corresponding author), Chinese Acad Sci, Key Lab Syst Microbial Biotechnol, Tianjin 300308, Peoples R China.
EM liu_t@tib.cas.cn
FU Drug Innovation Major Project [2018ZX09711001-006-003]; National Natural
   Science Foundation of China [31400026]; Youth Innovation Promotion
   Association CAS [2017207]; Biological Resources Service Plan of CAS
   [ZSTH-023]; Sciences and Technology Planning Projects of Tianjin City
   [18YFZCSY01350]; Tianjin Science and Technology Project [15PTCYSY00020]
FX This work was supported by the Drug Innovation Major Project
   (2018ZX09711001-006-003), the National Natural Science Foundation of
   China (31400026), the Youth Innovation Promotion Association CAS
   (2017207), the Biological Resources Service Plan of CAS (ZSTH-023), the
   Sciences and Technology Planning Projects of Tianjin City
   (18YFZCSY01350), and the Tianjin Science and Technology Project
   (15PTCYSY00020).
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NR 40
TC 11
Z9 18
U1 1
U2 73
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 2161-5063
J9 ACS SYNTH BIOL
JI ACS Synth. Biol.
PD AUG
PY 2019
VL 8
IS 8
BP 1931
EP 1940
DI 10.1021/acssynbio.9b00219
PG 10
WC Biochemical Research Methods
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA IS2JQ
UT WOS:000481979300025
PM 31291541
DA 2026-05-27
ER

PT J
AU Wu, LD
   Yan, J
   Hu, JS
   Pang, DR
   Ji, YT
   Gong, DD
AF Wu, Lidan
   Yan, Jing
   Hu, Jiangshan
   Pang, Daoran
   Ji, Yuting
   Gong, Dandan
TI Full-spectrum HPLC fingerprint with binary evaluation system and
   chemometrics for herbal medicine quality-efficacy control
SO JOURNAL OF CHROMATOGRAPHY A
LA English
DT Article
DE Quality control; Herbal medicine; Full-spectrum time-domain integral
   accumulation; Binary evaluation system; Fingerprint-efficacy
   correlationship
AB Traditional chromatographic fingerprints for multi-herb preparations often collapse a diode-array detector (DAD) lambda-t cube to one or two wavelengths, masking weak- or non-UV components and limiting their value for stringent quality control. Seeking a more comprehensive yet routine friendly approach, we developed a full-spectrum time-domain integral accumulation (FTIA) strategy that numerically integrates each voxel of the DAD cube and fuses it with evaporative light-scattering detector traces to generate a single, information-rich fingerprint. 32 batches of Zhenqi Fuzheng preparation (ZQFZP) sourced from three manufacturers were profiled, and a binary evaluation system (BES) was designed to separate pattern similarity (S-m) from quantitative agreement (P-m), overcoming the equal-weight bias of cosine metrics. The method showed excellent analytical performance and, when coupled with principal component analysis, resolved clear inter-manufacturer clusters that the conventional single-wavelength fingerprint failed to distinguish. BES quantified these differences: one supplier produced batches with ten-fold deficits in several phenylethanoid glycosides (P-m 3-21 %), whereas another yielded systematic enrichment (P-m>120 %). Partial least squares regression attributed 98 % of P-m variance to four orthogonal markers (salidroside, specnuezhenide, ononin and formononetin). A marker-rich batch restored spleen and thymus indices and normalized serum IgG, interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) to 85-95 % of baseline in a cyclophosphamide-induced immunosuppressed mouse model, supporting a direct chemistry to efficacy link. These findings demonstrated that FTIA coupled with BES could deliver a regulator friendly, high resolution quality assessment strategy that unites exhaustive chemical coverage with biologically relevant metrics, offering a transferable method for the consistent production of complex natural medicines.
C1 [Wu, Lidan; Yan, Jing; Hu, Jiangshan; Pang, Daoran; Gong, Dandan] Shandong Univ Tradit Chinese Med, Inst Pharmaceut Res, Jinan 250355, Peoples R China.
   [Ji, Yuting] Shandong Univ Tradit Chinese Med, Clin Med Coll 1, Jinan 250355, Peoples R China.
C3 Shandong University of Traditional Chinese Medicine; Shandong University
   of Traditional Chinese Medicine
RP Gong, DD (corresponding author), Shandong Univ Tradit Chinese Med, Inst Pharmaceut Res, Jinan 250355, Peoples R China.
EM syphuddg@126.com
FU Natural Science Youth Founda-tion of Shandong Province, China
   [ZR2024QH152]; Natural Science Youth Foundation of Shandong Province,
   China [ZR2023QH309]
FX This research was supported by the Natural Science Youth Founda-tion of
   Shandong Province, China (No. ZR2024QH152) and the Natural Science Youth
   Foundation of Shandong Province, China (No. ZR2023QH309) .
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NR 37
TC 1
Z9 1
U1 6
U2 12
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0021-9673
EI 1873-3778
J9 J CHROMATOGR A
JI J. Chromatogr. A
PD OCT 25
PY 2025
VL 1761
AR 466399
DI 10.1016/j.chroma.2025.466399
EA SEP 2025
PG 11
WC Biochemical Research Methods; Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 8DF6F
UT WOS:001585891800002
PM 41004897
DA 2026-05-27
ER

PT J
AU Akram, W
   Najmi, A
   Alam, MM
   Haque, SE
AF Akram, Wasim
   Najmi, Abul Kalam
   Alam, M. Mumtaz
   Haque, Syed Ehtaishamul
TI Levocabastine ameliorates cyclophosphamide-induced cardiotoxicity in
   Swiss albino mice: Targeting TLR4/NF-κB/NLRP3 signaling pathway
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
DE Cardiotoxicity; Levocabastine; Oxidative stress; Cyclophosphamide;
   Cardiac inflammation
ID OXIDATIVE STRESS; IN-VIVO; KAPPA-B; SALIDROSIDE; INJURY; TISSUE; BRAIN;
   ALPHA; CELLS; ACID
AB Cyclophosphamide (CP), although a potent anti-cancer drug, causes cardiotoxicity as a side effect that limits its use. Hence, a specific medicine that can lower cardiotoxicity and be utilised as an adjuvant in cancer treatment is very much needed. In this light, we intended to assess the protective potential of levocabastine (LEV) on CPinduced cardiotoxicity in Swiss albino mice. Mice were administered LEV (50 and 100 mu g/kg, i.p.) daily for 14 days and CP at 200 mg/kg, intraperitoneally once on the 7th day. On the 15th day, mice were weighed, blood withdrawn then sacrificed and hearts were removed to estimate various biochemical and histopathological parameters. CP 200 mg/kg significantly increased cardiac troponin T, LDH, CK-MB, interleukin-1 beta, IL-6, TNF-alpha, TBARS, nitrite, and decreased CAT, GSH, and SOD levels, thus, manifested cardiac damage, inflammation, oxidative stress, and nitrative stress, cumulatively causing cardiotoxicity. CP also elevated the expression of various markers including cleaved caspase-3, NF-kappa B, TLR4, NLRP3, and fibrotic lesions in cardiac tissues, whereas decreased hematological parameters (RBCs, platelets, and Hb) to confirm cardiotoxicity. LEV and fenofibrate (FF) treatment reversed these changes towards normal and showed a significant protective effect against CP. The results showed the protective role of LEV in restoring CP-induced cardiotoxicity in terms of inflammation, apoptosis, oxidative stress, cardiac injury and histopathological damage. Thus, levocabastine can be used as an adjuvant to cyclophosphamide in cancer treatment but a thorough study with various animal cancer models is further needed to establish the fact.
C1 [Akram, Wasim; Najmi, Abul Kalam; Haque, Syed Ehtaishamul] Jamia Hamdard, Sch Pharmaceut Educ & Res, Dept Pharmacol, New Delhi 110062, India.
   [Alam, M. Mumtaz] Jamia Hamdard, Sch Pharmaceut Educ & Res, Dept Pharmaceut Chem, New Delhi 110062, India.
   [Haque, Syed Ehtaishamul] Jamia Hamdard, SPER, Dept Pharmacol, New Delhi 110062, India.
C3 Jamia Hamdard University; Jamia Hamdard University; Jamia Hamdard
   University
RP Haque, SE (corresponding author), Jamia Hamdard, SPER, Dept Pharmacol, New Delhi 110062, India.
EM sehaq@jamiahamdard.ac.in
RI Akram, Wasim/IAM-9621-2023
OI Akram, Wasim/0000-0003-3451-9305
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NR 61
TC 6
Z9 8
U1 0
U2 9
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0041-008X
EI 1096-0333
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD FEB
PY 2024
VL 483
AR 116838
DI 10.1016/j.taap.2024.116838
EA JAN 2024
PG 13
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA KD4P7
UT WOS:001178011600001
PM 38278497
DA 2026-05-27
ER

PT J
AU Zomborszki, ZP
   Kúsz, N
   Csupor, D
   Peschel, W
AF Zomborszki, Zoltan Peter
   Kusz, Norbert
   Csupor, Dezso
   Peschel, Wieland
TI Rhodiosin and herbacetin in Rhodiola rosea preparations:
   additional markers for quality control?
SO PHARMACEUTICAL BIOLOGY
LA English
DT Article
DE HPLC; flavonoid
ID PHENYLPROPENOID CONTENT; PHENOLIC-COMPOUNDS; HARVEST SEASON; 4
   FLAVONOIDS; PLANT-PART; L.; CONSTITUENTS; ANTIOXIDANT; IDENTIFICATION;
   SEPARATION
AB Context: Rhodiola rosea L. (Crassulaceae) is well-known to contain flavonoids such as the herbacetin derivative rhodiosin. However, flavonoids are not typically used in quality control. Objective: This study analyses two flavonoids of R. rosea rhizomes and roots for their potential as analytical markers. Materials and methods: Two constituents were isolated from ethanolic extracts via HPLC, identified via NMR and quantified via RP-HPLC. Presence and content variation was investigated according to extraction (solvent and repetitions), drying (temperature and duration) and sample origin (homogenously cultivated plants of different provenance, commercial samples). Results: Rhodiosin was identified as a main flavonoid, accompanied by 10-fold lower concentrated herbacetin. Both compounds were best extracted with 70-90% ethanol, but were also detectable in more aqueous extracts. Different drying conditions had no effect on the flavonoid content. These two flavonoids were consistently identified in rhizome and root extracts of over 100 R. rosea samples. Rhizomes tend to contain less flavonoids, with average ratios of rosavins to flavonoids of 1.4 (rhizomes) and 0.4 (roots). Provenance differences were detected in the range (rhodiosin plus herbacetin) of 760-6300 mu g/mL extract corresponding to a maximum of approximately 0.5-4.2% (w/w) in the dry drug. Conclusions: For the first time, two main flavonoids present in R. rosea were quantified systematically. Rhodiosin and herbacetin can be detected simultaneously to phenylpropenoids or salidroside in authentic samples, influenced by the plant part examined and the plant origin. Rhodiosin and herbacetin may serve as additional marker to guarantee a consistent content of R. rosea products.
C1 [Zomborszki, Zoltan Peter; Kusz, Norbert; Csupor, Dezso] Univ Szeged, Fac Pharm, Dept Pharmacognosy, Eotvos U 6, H-6720 Szeged, Hungary.
   [Zomborszki, Zoltan Peter; Kusz, Norbert; Csupor, Dezso] Univ Szeged, Interdisciplinary Ctr Nat Prod, Szeged, Hungary.
   [Peschel, Wieland] European Med Agcy, 30 Churchill Pl, London E14 5EU, England.
C3 Szeged University; Szeged University
RP Csupor, D (corresponding author), Univ Szeged, Fac Pharm, Dept Pharmacognosy, Eotvos U 6, H-6720 Szeged, Hungary.; Peschel, W (corresponding author), European Med Agcy, 30 Churchill Pl, London E14 5EU, England.
EM csupor.dezso@pharm.u-szeged.hu; wieland.peschel@ema.europa.eu
RI ; Csupor, Dezső/ABE-1830-2021
OI Kúsz, Norbert/0000-0002-9973-6442; Csupor, Dezső/0000-0002-4088-3333
FU National Research, Development and Innovation Office [OTKA K115796];
   Economic Development and Innovation Operative Programme
   [GINOP-2.3.2-15-2016-00012]; Janos Bolyai Research Scholarship of the
   Hungarian Academy of Sciences
FX This work was supported by the National Research, Development and
   Innovation Office [OTKA K115796], the Economic Development and
   Innovation Operative Programme GINOP-2.3.2-15-2016-00012 and Janos
   Bolyai Research Scholarship of the Hungarian Academy of Sciences.
CR [Anonymous], 2015, REV B, P1
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NR 34
TC 23
Z9 25
U1 0
U2 17
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1388-0209
EI 1744-5116
J9 PHARM BIOL
JI Pharm. Biol.
PD JAN 1
PY 2019
VL 57
IS 1
BP 295
EP 305
DI 10.1080/13880209.2019.1577460
PG 11
WC Plant Sciences; Medical Laboratory Technology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Medical Laboratory Technology; Pharmacology & Pharmacy
GA IM2TT
UT WOS:000477845500001
PM 31356124
OA Green Submitted, Green Accepted, gold
DA 2026-05-27
ER

PT J
AU Li, A
   Liu, YG
   Zhai, L
   Wang, LY
   Lin, Z
   Wang, SM
AF Li, Ang
   Liu, Yuguang
   Zhai, Lu
   Wang, Liying
   Lin, Zhe
   Wang, Shumin
TI Activating Peroxisome Proliferator-Activated Receptors (PPARs): a New
   Sight for Chrysophanol to Treat Paraquat-Induced Lung Injury
SO INFLAMMATION
LA English
DT Article
DE chrysophanol; paraquat; lung injury; PPAR-gamma; NF-kappa B
ID KAPPA-B PATHWAY; IN-VITRO; PLATYCODIN D; INFLAMMATION; MICE;
   SALIDROSIDE; RATS; VIVO; ARTHRITIS; APIGENIN
AB The aim of this study is to evaluate the protective effects of chrysophanol (CH) against paraquat (PQ)-induced pulmonary injury. Fifty BALB/C mice were randomized into five groups: (1) control, (2) PQ, (3) PQ + dexamethasone (Dex, 2 mg/kg), (4) PQ + CH (10 mg/kg), and (5) PQ + CH (20 mg/kg). A single dose of PQ (50 mg/kg, i.p.) was intraperitoneally given to induce acute lung injury. Then mice were treated with CH (10 and 20 mg/kg/day, orally) for 7 days. At the end of the experiment, animals were euthanized and then bronchoalveolar lavage fluid (BALF) and lung tissues were collected for histological observation, biochemical analysis, and Western blot analysis. Malondialdehyde (MDA), myeloperoxidase (MPO), superoxide dismutase (SOD), interleukin-6 (IL-6), IL-1 beta, and tumor necrosis factor-alpha (TNF-alpha) levels in BALF were determined. The levels of SOD and MDA in the lung were also detected. The peroxisome proliferator-activated receptor (PPAR)-gamma and nuclear factor-kappaB (NF-kappa B) pathway proteins in the lung were determined by Western blot. Histological examination indicated that CH attenuated lung inflammation caused by PQ. Biochemical results showed that CH treatment significantly reduced the levels of MDA, MPO, and inflammatory cytokines and increased the level of SOD, compared to those in the PQ group. Meanwhile, Western Blot results revealed that CH increased PPAR-gamma expression and inhibited NF-kappa B pathway activation after PQ challenge. These findings suggested the potential therapeutic effects of CH which is derived from a natural product on PQ-induced pulmonary injury.
C1 [Li, Ang; Liu, Yuguang; Zhai, Lu; Wang, Liying; Lin, Zhe; Wang, Shumin] Changchun Univ Tradit Chinese Med, Changchun 130117, Jilin, Peoples R China.
C3 Changchun University of Chinese Medicine
RP Wang, SM (corresponding author), Changchun Univ Tradit Chinese Med, Changchun 130117, Jilin, Peoples R China.
EM wangshuminch@126.com
RI ; Wang, Liying/NXY-0062-2025
OI LI, Ang/0000-0002-3312-1891; 
FU Natural Science Foundation of Jiangsu Province of China [BK20150707];
   Fundamental Research Funds for the Central Universities [JKZD2013009,
   ZJ15030]; Priority Academic Program Development of Jiangsu Higher
   Education Institutions (PAPD); Research Innovation Program Project for
   Graduate Students in Jiangsu Province [CXZZ13_03]; National
   Undergraduate Training Programs for Innovation and Entrepreneurship
   [G13034]
FX This study was supported by grants of the Natural Science Foundation of
   Jiangsu Province of China (BK20150707) and the Fundamental Research
   Funds for the Central Universities (JKZD2013009 and ZJ15030). This
   project also funded by the Priority Academic Program Development of
   Jiangsu Higher Education Institutions (PAPD), Research Innovation
   Program Project for Graduate Students in Jiangsu Province (CXZZ13_03),
   and National Undergraduate Training Programs for Innovation and
   Entrepreneurship (G13034).
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NR 36
TC 31
Z9 36
U1 1
U2 14
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0360-3997
EI 1573-2576
J9 INFLAMMATION
JI Inflammation
PD APR
PY 2016
VL 39
IS 2
BP 928
EP 937
DI 10.1007/s10753-016-0326-2
PG 10
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA DJ3KE
UT WOS:000374103000049
PM 26920845
DA 2026-05-27
ER

PT J
AU Zhang, K
   Liu, JY
   You, XT
   Kong, P
   Song, YC
   Cao, L
   Yang, S
   Wang, WB
   Fu, Q
   Ma, ZQ
AF Zhang, Kai
   Liu, Jingyan
   You, Xintong
   Kong, Ping
   Song, Yichen
   Cao, Lu
   Yang, Song
   Wang, Wenbing
   Fu, Qiang
   Ma, Zhangqiang
TI P2X7 as a new target for chrysophanol to treat
   lipopolysaccharide-induced depression in mice
SO NEUROSCIENCE LETTERS
LA English
DT Article
DE Chrysophanol; P2X7; Depression; Inflammation
ID ACUTE LUNG INJURY; ADJUVANT-INDUCED ARTHRITIS; SERUM CYTOKINES;
   LIVER-INJURY; MOUSE MODEL; IN-VITRO; BEHAVIOR; RECEPTOR; SALIDROSIDE;
   ACTIVATION
AB P2X7 receptor is a ligand gated ion channel found peripheral macrophages and microglia in the nervous system. The current study investigated the relationship between the activated P2X7 and depression for the first time. Chrysophanol (Chr) was examined for its protective effects against depression targeting P2X7. Chr (20 mg/kg, 40 mg/kg) and fluoxetine (20 mg/kg) were intragastrically treated once daily for 7 consecutive days. Lipopolysaccharide (LPS, 0.5 mg/kg) was intraperitoneally injected to develop depression model 30 min after drug administration on day 7. Behavioral tests were measured 24 h after LPS injection. Interleukin (IL) -6, IL-1 beta and tumor necrosis factor (TNF)-alpha levels in serum and hippocampus were measured by enzyme-linked immunosorbent assay (ELISA). The expresSions of P2X7/NF-kappa B pathway-related proteins were assessed by western blot. The findings showed that Chr remarkably reduced the elevations of IL-6, IL-1 beta and TNF-alpha caused by LPS stimulation. The expressions of P2X7, p-IKK alpha, p-IKK beta, p-I kappa B alpha and p-NF-kappa Bp65 were significantly decreased by Chr pretreatment. In addition, immobility time in tail suspension test (TST) and forced swimming test (FST) were reduced by Chr without affecting spontaneous locomotor activity in open filed test (OFT) and the preference for sucrose was also recovered in sucrose preference test (SPT) with Chr preconditioning. Thus, it is reasonable to speculate that Chr might exert antidepressant effect through inhibiting P2X7/NF-kappa B signaling pathway. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
C1 [Zhang, Kai; Song, Yichen; Fu, Qiang; Ma, Zhangqiang] China Pharmaceut Univ, Dept Pharmacol Chinese Mat Med, Nanjing 210009, Jiangsu, Peoples R China.
   [Liu, Jingyan] China Pharmaceut Univ, Dept Physiol & Pharmacol, Nanjing 210009, Jiangsu, Peoples R China.
   [You, Xintong] Nanjing Forestry Univ, Dept Polymer Mat & Engn, Nanjing 210037, Jiangsu, Peoples R China.
   [Kong, Ping] Nanjing Hongshi Pharmaceut Management Serv Co Ltd, Nanjing 210046, Jiangsu, Peoples R China.
   [Cao, Lu] China Pharmaceut Univ, Dept Clin Pharm, Nanjing 210009, Jiangsu, Peoples R China.
   [Yang, Song] Nanjing Shunan Med Apparat Co, Nanjing 210000, Jiangsu, Peoples R China.
   [Wang, Wenbing] China Pharmaceut Univ, Sch Pharm, Nanjing 210009, Jiangsu, Peoples R China.
C3 China Pharmaceutical University; China Pharmaceutical University;
   Nanjing Forestry University; China Pharmaceutical University; China
   Pharmaceutical University
RP Fu, Q; Ma, ZQ (corresponding author), China Pharmaceut Univ, Dept Pharmacol Chinese Mat Med, Nanjing 210009, Jiangsu, Peoples R China.
EM fuqiangnanjing@126.com; mazhanqiangnanjing@126.com
RI CAO, LU/JAO-4115-2023
FU Natural Science Foundation of Jiangsu Province of China [BK20150707];
   Fundamental Research Funds for the Central Universities [JKZD2013009,
   ZJ15030]; Priority Academic Program Development of Jiangsu Higher
   Education Institutions (PAPD); Research Innovation Program Project for
   Graduate Students in Jiangsu Province [CXZZ13_03]; National
   Undergraduate Training Programs for Innovation and Entrepreneurship
   [G13034]; Representational Achievement Cultivating Project of State Key
   Laboratory of Natural Medicines [SKLNMBZ201402]
FX This study was supported by grants of the Natural Science Foundation of
   Jiangsu Province of China (BK20150707) and the Fundamental Research
   Funds for the Central UniversitiesJKZD2013009 and ZJ15030). This Project
   also funded by the Priority Academic Program Development of Jiangsu
   Higher Education Institutions (PAPD), Research Innovation Program
   Project for Graduate Students in Jiangsu Province (CXZZ13_03), National
   Undergraduate Training Programs for Innovation and Entrepreneurship
   (G13034) and the Representational Achievement Cultivating Project of
   State Key Laboratory of Natural Medicines (SKLNMBZ201402).
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NR 37
TC 91
Z9 96
U1 1
U2 66
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0304-3940
EI 1872-7972
J9 NEUROSCI LETT
JI Neurosci. Lett.
PD FEB 2
PY 2016
VL 613
BP 60
EP 65
DI 10.1016/j.neulet.2015.12.043
PG 6
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA DC8IN
UT WOS:000369463200011
PM 26724370
DA 2026-05-27
ER

PT J
AU Volkova, LA
   Urmantseva, VV
   Burgutin, AB
AF Volkova, L. A.
   Urmantseva, V. V.
   Burgutin, A. B.
TI Stress-protective effect of phenylpropanoid complex on potato plants in
   vitro
SO RUSSIAN JOURNAL OF PLANT PHYSIOLOGY
LA English
DT Article
DE Rhodiola rosea; Solanum tuberosum; in vitro; phenylpropanoids;
   antiradical properties; oxidative stress
ID CELL-CULTURE; PEROXIDASE; DEFENSE; ROS
AB In order to identify factors governing the maintenance of intracellular redox homeostasis, we investigated the effect of phenylpropanoid complex (PPC) isolated from the root extract of Golden root (Rhodiola rosea L.) on the plants of potato (Solanum tuberosum L.) in vitro. It was found that plant treatment with 100 mu M PPC brought about a 23% decrease in peroxidase activity in the cells of potato plants and induced a reversible increase in the level of lipid peroxidation (POL) under oxidative stress caused by paraquat. In the presence of NADH known as an oxidase substrate of peroxidases (PO), a decrease in peroxidase activity was associated with switching peroxidase over to oxidase function. This effect was accompanied by a rise in the superoxide dismutase activity by 34% and identical POL elevation. After plant pretreatment with NADPH-oxidase inhibitor diphenylene iodinum, the stimulation of these processes upon the exposure to PPC decreased by 14 and 24%, respectively. This may point to the participation of a PO/NADPH-oxidase tandem in ROS generation. Along with a decrease in peroxidase function of PO, we also observed an opposite effect: in 3 h after the exposure to PPC, its activity rose, which depended on the ability of PPC to switch peroxidase from oxidative to reductive function and back. It was found that the observed effects of PPC comprise not only the respective modulation of antioxidant enzyme activity but also direct ROS quenching. The latter effect of PPC, detected by the rate of a decrease in the level of superoxide anion considerably exceeded the effect of individual antioxidants (salidroside and ascorbic acid), whose inhibitory activity was 5 times lower than the activity of PPC.
C1 [Volkova, L. A.; Urmantseva, V. V.; Burgutin, A. B.] Russian Acad Sci, KA Timiryazev Plant Physiol Inst, Moscow 127276, Russia.
C3 Russian Academy of Sciences; Timiryazev Institute of Plant Physiology
RP Volkova, LA (corresponding author), Russian Acad Sci, KA Timiryazev Plant Physiol Inst, Bot Skaya Ul 35, Moscow 127276, Russia.
EM la-volkova@yandex.ru
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NR 26
TC 8
Z9 10
U1 0
U2 13
PU PLEIADES PUBLISHING INC
PI MOSCOW
PA PLEIADES PUBLISHING INC, MOSCOW, 00000, RUSSIA
SN 1021-4437
EI 1608-3407
J9 RUSS J PLANT PHYSL+
JI Russ. J. Plant Physiol.
PD MAR
PY 2014
VL 61
IS 2
BP 255
EP 261
DI 10.1134/S1021443714010166
PG 7
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences
GA AC7OA
UT WOS:000332718200014
DA 2026-05-27
ER

PT J
AU Mora, MC
   Bassa, LM
   Wong, KE
   Tirabassi, MV
   Arenas, RB
   Schneider, SS
AF Mora, Maria Carmen
   Bassa, Lotfi M.
   Wong, Kaitlyn E.
   Tirabassi, Michael V.
   Arenas, Richard B.
   Schneider, Sallie S.
TI Rhodiola crenulata inhibits Wnt/β-catenin signaling in
   glioblastoma
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE Rhodiola; Glioblastoma; Wnt; beta-Catenin; GFAP; Differentiation
ID APOPTOSIS; EXTRACT; GROWTH; TUMOR; PROLIFERATION; SALIDROSIDE;
   EXPRESSION; INDUCTION
AB Background: Rhodiola crenulata is a perennial plant that grows in the high altitudes of Eastern Europe and Asia. R crenulata has been used for many years in Eastern traditional medicine for a variety of medicinal purposes and it has been shown to elicit antineoplastic effects. The purpose of this study is to determine if R crenulata extract exhibits antitumor properties on glioblastoma multiforme (GBM), the most common and aggressive primary brain tumor.
   Materials and Methods: Human U87 GBM cells were treated with 200 mu g/mL of R crenulata or vehicle control. Cell proliferation was measured via MTS assay and clonogenic assay. The expressions of glial fibrillary acidic protein, a protein marker of differentiation, E-cadherin, and nonephospho active beta-catenin were measured with immunocytochemistry. Neurosphere assay was performed in low attachment plates. Activity of the Wnt/beta-catenin transcriptional activation was assessed via a dual-luciferase assay.
   Results: MTS and clonogenicity assays revealed a decrease in proliferation with R crenulata therapy with an increased sensitivity to radiation. Immunocytochemistry revealed that R crenulata induced glial fibrillary acidic protein and E-cadherin expression suggestive of a more differentiated state. In agreement with the change in differentiation neurosphere formation was decreased upon treatment with R crenulata. beta-Catenin dual reporter assay revealed a decrease in Wnt promoter activity after treatment with R crenulata; this was supported by a decrease in nuclear localization of beta-catenin.
   Conclusions: Treatment with R crenulata extract effectively suppresses proliferation, stimulates differentiation, and eliminates tumorsphere formation of GBM cells in vitro. The observed effects are associated with inhibition of Wnt/b-catenin signaling pathway. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Mora, Maria Carmen; Wong, Kaitlyn E.; Arenas, Richard B.] Tufts Univ Sch Med, Dept Surg, Baystate Med Ctr, Springfield, MA USA.
   [Mora, Maria Carmen; Bassa, Lotfi M.; Wong, Kaitlyn E.; Arenas, Richard B.; Schneider, Sallie S.] Pioneer Valley Life Sci Inst, Springfield, MA USA.
   [Bassa, Lotfi M.; Wong, Kaitlyn E.; Arenas, Richard B.; Schneider, Sallie S.] Univ Massachusetts Amherst, Amherst, MA USA.
   [Tirabassi, Michael V.] Tufts Univ Sch Med, Baystate Childrens Hosp, Dept Pediat Surg, Springfield, MA USA.
   [Schneider, Sallie S.] Baystate Med Ctr, Dept Acad Affairs, Springfield, MA USA.
C3 Tufts University; Baystate Medical Center; University of Massachusetts
   System; University of Massachusetts Amherst; Tufts University; Baystate
   Medical Center
RP Schneider, SS (corresponding author), Univ Massachusetts Amherst, Pioneer Valley Life Sci Inst, Baystate Med Ctr, 3601 Main St, Springfield, MA 01199 USA.
EM Sallie.Schneider@baystatehealth.org
OI Mora, Maria Carmen/0000-0002-1961-7882
FU internal Baystate Medical Center grant
FX We would like to thank Jennifer Ser-Dolansky for assisting with
   immunocytochemistry. This work was funded by an internal Baystate
   Medical Center grant.
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NR 30
TC 19
Z9 25
U1 1
U2 17
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD AUG
PY 2015
VL 197
IS 2
BP 247
EP 255
DI 10.1016/j.jss.2015.02.074
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CK3CZ
UT WOS:000356095100006
PM 25998182
DA 2026-05-27
ER

PT J
AU Zhou, YZ
   Liu, XH
   Chen, F
   Zhang, FS
AF Zhou, Yizhi
   Liu, Xunhong
   Chen, Fei
   Zhang, Fengsu
TI Simultaneous quantitative determination of eight index constituents and
   compatibility changes in Longchai Decoction by UPLC-Q-TOF-MS
SO ACTA PHARMACEUTICA SINICA B
LA English
DT Article
DE ITPLC-Q-TOF-Ms; Longchai Decoction; Quantitative determination;
   Compatibility
ID LIQUID; SAPONINS; IDENTIFICATION; METABOLITES; COMPONENTS; GINSENG; TANG
AB The goal of this research was to develop a simple, rapid and sensitive method for simultaneous quantitative determination of salidroside, gardenoside, liquiritin, baicalin, wogonoside, wogonin, saikosaponin A and saikosaponin D in Longchai Decoction by ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC Q-TOF-MS), in order to control the quality of Longchai Decoction and to analyze the changes of chemical components before and after the compatibility of the component herb drugs. The chromatographic separation was performed on the Waters ACQUITY BEH C18 column (2.1 mm x 100 mm, 1.8 um) using the mixture of acetonitrile and 0.1% (v/v) methanoic acid as mobile phase with a gradient elution program at the flow rate of 0.3 mL/min and the column temperature of 30 degrees C. The eight components of the standards achieved baseline separation. Regression analysis revealed a linear relationship (r(2)>0.9998) between the contents and the peak areas of the mixed standard substances. The average recovery rates were between 99.72% and 102.13% with RSD values were less than 2.82% (n=5). The obtained results indicated that the content of index components were higher in co-decoction compared to mixed decoction. This method with a good resolution and high precision can be used for the quality control of Longchai Decoction. (C) 2013 Institute of Materia Medica, Chinese Academy of Medical Sciences and Chinese Pharmaceutical Association. Production and hosting by Elsevier B.V. All rights reserved.
C1 [Zhou, Yizhi; Liu, Xunhong; Chen, Fei; Zhang, Fengsu] Nanjing Univ Chinese Med, Nanjing 210023, Jiangsu, Peoples R China.
C3 Nanjing University of Chinese Medicine
RP Liu, XH (corresponding author), Nanjing Univ Chinese Med, Nanjing 210023, Jiangsu, Peoples R China.
EM liuxunh1959@sohu.com
RI Zhou, Yizhi/KEJ-3463-2024
FU Science and Technology Foundation Construction Plan of Jiangsu Province
   [BM2009903]; Priority Academic Program Development of Jiangsu Higher
   Education Institutions [ysxk-2010]
FX This project was supported by the Science and Technology Foundation
   Construction Plan of Jiangsu Province (No. BM2009903) and a project
   funded by the Priority Academic Program Development of Jiangsu Higher
   Education Institutions (No. ysxk-2010).
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TC 5
Z9 5
U1 1
U2 14
PU INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
PI BEIJING
PA C/O EDITORIAL BOARD OF ACTA PHARMACEUTICA SINICA, 1 XIANNONGTAN ST,
   BEIJING, 100050, PEOPLES R CHINA
SN 2211-3835
EI 2211-3843
J9 ACTA PHARM SIN B
JI Acta Pharm. Sin. B
PD JUL
PY 2013
VL 3
IS 4
BP 281
EP 287
DI 10.1016/j.apsb.2013.06.006
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA VB1FE
UT WOS:000413450000010
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Deng, M
   Zhai, ZB
   Zhang, HL
   Shi, XL
   Wen, YM
   Cheng, D
   He, LW
   Li, SJ
AF Deng, Min
   Zhai, Zibo
   Zhang, Hailin
   Shi, Xuelin
   Wen, Yaman
   Cheng, Dan
   He, Longwei
   Li, Songjiao
TI Rational Construction of a Lipid Droplet-Targeted Redox-Responsive
   Ratiometric Probe for Screening of Antioxidant Drugs and Its Application
   in Parkinson's Disease
SO ANALYTICAL CHEMISTRY
LA English
DT Article
ID HYPOCHLOROUS ACID; HCLO
AB Parkinson's disease (PD) is a neurodegenerative disorder that is increasingly prevalent due to global aging, requiring urgent efforts to uncover its pathogenic mechanisms and develop effective treatments. Abnormal lipid metabolism in glial cells is a key pathological feature of PD, and identifying lipid droplets (LDs) is crucial for studying lipid metabolism, disease progression, and potential therapies. Ferroptosis, a regulated form of cell death induced by iron-dependent lipid peroxides, is a critical mechanism in PD. Ferroptosis is closely linked to PD progression and redox homeostasis, regulated by reactive oxygen and sulfur species. Understanding changes in redox homeostasis in LDs during ferroptosis in the brain is key to understanding PD pathology. However, the development of fast-responding and highly sensitive reversible fluorescent probes for monitoring of LDs redox changes during ferroptosis and PD is still lacking. To address this, we developed RHG-Se-5F, a reversible, ratiometric, LDs-targeted fluorescent probe that detects fluctuations in HClO/GSH levels. RHG-Se-5F visualized HClO elevation and GSH depletion in LDs during ferroptosis. We also established a high-throughput screening platform and identified Salidroside (Sal) as a potent ferroptosis inhibitor. Sal promotes GSH synthesis, scavenges ROS, and activates the Nrf2/GPX4 pathway, protecting neurons from ferroptosis. RHG-Se-5F can image HClO/GSH levels in brain tissue, showing increased HClO levels in PD mouse brains as PD progresses, validating its potential in PD pathology. In conclusion, RHG-Se-5F is a valuable molecular tool for in situ fluorescence labeling of redox levels in biological samples, with broad potential for neurobiological research and the diagnosis and monitoring of neurological diseases.
C1 [Deng, Min; Zhai, Zibo; Zhang, Hailin; Shi, Xuelin; Wen, Yaman; Cheng, Dan; He, Longwei; Li, Songjiao] Univ South China, Sch Pharmaceut Sci, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.
   [Cheng, Dan] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Clin Res Inst,Dept Gastroenterol, Hengyang 421002, Peoples R China.
   [He, Longwei] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Peoples R China.
C3 University of South China; University of South China; Henan Normal
   University
RP He, LW; Li, SJ (corresponding author), Univ South China, Sch Pharmaceut Sci, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.; He, LW (corresponding author), Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Peoples R China.
EM helongwei0110@163.com; lisongjiaoo@126.com
RI ; li, songjiao/KJL-2344-2024
OI He, Longwei/0000-0002-8206-8783; 
FU Natural Science Foundation of Hunan Province [2022JJ30484]; National
   Natural Science Foundation of China [22304074]; School of Chemistry and
   Chemical Engineering, Henan Normal University [2024Y13]
FX This work was supported by the National Natural Science Foundation of
   China (22304074), the Natural Science Foundation of Hunan Province
   (2025JJ50072, 2022JJ30484, and 2022JJ40358), and the Hunan Provincial
   Innovation and Entrepreneurship Training Program for Undergraduate
   (S202410555190, DC20250028, DC20250170, and DC20250196). The Open Fund
   of School of Chemistry and Chemical Engineering, Henan Normal University
   (2024Y13).
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NR 42
TC 3
Z9 3
U1 18
U2 18
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0003-2700
EI 1520-6882
J9 ANAL CHEM
JI Anal. Chem.
PD JAN 13
PY 2026
VL 98
IS 1
BP 809
EP 817
DI 10.1021/acs.analchem.5c05923
EA DEC 2025
PG 9
WC Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA CA2ZQ
UT WOS:001642245000001
PM 41410258
DA 2026-05-27
ER

PT J
AU Liu, Y
   Ren, P
   Li, HL
   Liu, YY
   Yang, YT
   Wang, WT
   Zhou, JM
   Su, L
   Guan, LL
   Ma, HX
AF Liu, Yue
   Ren, Ping
   Li, Hailong
   Liu, Yingying
   Yang, Yiting
   Wang, Wanting
   Zhou, Jiaming
   Su, Ling
   Guan, Lili
   Ma, Hongxia
TI Nostoc commune Vauch. polysaccharide alleviates Pb-induced hepatorenal
   toxicity by changing gut bacteriome, mycobiome, and metabolome
SO FOOD SCIENCE AND HUMAN WELLNESS
LA English
DT Article
DE Nostoc commune Vauch. polysaccharide; Lead; Hepatorenal injury; Gut
   bacteriobiota; Metabolome
ID LEAD-EXPOSURE; BENEFICIAL REGULATION; LIVER-INJURY; MICROBIOTA; CANCER;
   HEALTH; SUPPRESSION; FERROPTOSIS; MODULATE; PATHWAY
AB This study aimed to explore the protective effect and potential mechanism of Nostoc commune Vauch. polysaccharide (NCVP) on lead (Pb)-poisoning mice. NCVP improved Pb-induced hepatorenal toxicity and inflammatory responses and modulated key indicators of antioxidant capacity. Moreover, the down-regulation of critical proteins of the Nrf2 pathway induced by Pb could be reversed after NCVP intervention. In addition, NCVP maintained the diversity of gut bacteriobiota and restored the relative abundance of f_Prevotellaceae, g_Alloprevotella, and f_Eubacterium_coprostanoligenes_group reduced by Pb. Also, NCVP regulated the diversity and abundance of gut mycobiota affected by Pb. Specifically, Pb decreased the proportion of pathogenic species (g_Fusarium, p_Basidiomycota, g_Alternaria, g_Aspergillus, and g_Candida) while NCVP increased the abundance of probiotics species (g_Kazachstania and p_Ascomycota). Furthermore, the metabolomic analysis found that NCVP significantly altered a range of microbial metabolites, including porphobilinogen, cromakalim, salidroside, and trichostatin A, which has significant associations with specific gut bacteriobiota or mycobiota. These altered metabolites are involved in primary bile acid biosynthesis, metabolism of xenobiotics by cytochrome P450, lysine degradation, and other metabolic pathways. Overall, our findings indicate that NCVP might be an excellent natural product for eliminating Pb-induced hepatorenal toxicity, possibly by regulating gut bacteriome, mycobiome and metabolome. (c) 2024 Beijing Academy of Food Sciences. Publishing services by Tsinghua University Press. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Liu, Yue; Ren, Ping; Li, Hailong; Liu, Yingying; Yang, Yiting; Wang, Wanting; Zhou, Jiaming; Guan, Lili; Ma, Hongxia] Jilin Agr Univ, Coll Life Sci, Changchun 130118, Peoples R China.
   [Guan, Lili; Ma, Hongxia] Jilin Agr Univ, Engn Res Ctr Bioreactor & Pharmaceut Dev, Minist Educ, Changchun 130118, Peoples R China.
   [Su, Ling] Jilin Agr Univ, Chinese Minist Educ Edible & Med Fungi, Engn Res Ctr, Changchun 130118, Peoples R China.
C3 Jilin Agricultural University; Jilin Agricultural University; Jilin
   Agricultural University
RP Guan, LL; Ma, HX (corresponding author), Jilin Agr Univ, Coll Life Sci, Changchun 130118, Peoples R China.
EM llguan@jlau.edu.cn; mahongxia@jlau.edu.cn
RI ZHOU, Jiaming/LYP-0930-2024
FU Program of the National Natural Science Foundation of China [31872519];
   General Project of Jilin Provincial Department of Science and Technology
   [20230101247JC]; Open Research Fund of Engineering Research Center of
   Bioreactor and Pharmaceutical Development, Ministry of Education
   [KF202002]
FX This work was supported by the Program of the National Natural Science
   Foundation of China (31872519); General Project of Jilin Provincial
   Department of Science and Technology (20230101247JC) and the Open
   Research Fund of Engineering Research Center of Bioreactor and
   Pharmaceutical Development, Ministry of Education. (KF202002) .
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NR 121
TC 1
Z9 1
U1 5
U2 21
PU TSINGHUA UNIV PRESS
PI BEIJING
PA B605D, XUE YAN BUILDING, BEIJING, 100084, PEOPLES R CHINA
EI 2213-4530
J9 FOOD SCI HUM WELL
JI Food Sci. Human Wellness
PD NOV
PY 2024
VL 13
IS 6
BP 3482
EP 3500
DI 10.26599/FSHW.2023.9250032
PG 19
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA Q7C2A
UT WOS:001386204200004
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Bai, LN
   Shi, W
   Liu, JP
   Zhao, XP
   Zhang, Y
   Zhou, ZG
   Hou, W
   Chang, T
AF Bai, Luning
   Shi, Wei
   Liu, Jiping
   Zhao, Xiaoping
   Zhang, Yi
   Zhou, Zhengguo
   Hou, Wen
   Chang, Tao
TI Protective effect of pilose antler peptide on cerebral
   ischemia/reperfusion (I/R) injury through Nrf-2/OH-1/NF-κB pathway
SO INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
LA English
DT Article
DE Pilose antler peptide; Middle cerebral artery occlusion;
   Nrf-2/HO-1/NF-kappa B
ID ISCHEMIA-REPERFUSION INJURY; ACUTE LUNG INJURY; ANTIISCHEMIC STROKE
   AGENT; NF-KAPPA-B; CANCER-THERAPY; BETULINIC ACID; INFLAMMATION;
   SALIDROSIDE; CHRYSOPHANOL; MECHANISMS
AB The purpose of the current study was to detect the effect of pilose antler peptide (PAP) on cerebral ischemia and explore its potential mechanism. Middle cerebral artery occlusion (MCAO) was performed to investigate the effects of PAP on cerebral ischemia. The rats were randomly divided into five groups: sham group, model(I/R) group, I/R+ Clopidogrel group, I/R+ PAP (50 mg/kg) group, I/R+ PAP (100 mg/kg) group. The results showed that PAP significantly reduced brain infarct size, inhibited cerebral edema, decreased th eneurological deficits. Treatment with PA reduced the contents of malondialdehyde(MDA) and restore the activity of superoxide dismutase(SOD) in serum and brains. Lig also could effectively decrease the levels of interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in serum and brain tissues of the MCAO rats. Western blot results demonstrated that PAP up-regulated the expressions of Nrf-2 and HO-1, also blocked the phosphorylations of I kappa B kinases(IKK)alpha, IKK beta, inhibitor of NF-kappa B(I kappa B)alpha, nuclear factor kappa B(NF-kappa B) p65 in I/R-induced brains. Our findings suggested that PAP effectively attenuated the I/R-induced cerebral ischemia through Nrf-2/HO-1/NF-kappa B pathway. (C) 2017 Elsevier B.V. All rights reserved.
C1 [Bai, Luning; Shi, Wei] Xian Jiao Tong Univ Xian, Med Coll, Xian 71000, Shaanxi, Peoples R China.
   [Bai, Luning; Zhao, Xiaoping; Zhang, Yi; Zhou, Zhengguo; Hou, Wen; Chang, Tao] Shaanxi Univ Chinese Med, Affiliated Hosp, Xianyang 712046, Peoples R China.
   [Liu, Jiping] Shaanxi Univ Chinese Med, Dept Pharmacol, Xianyang 712046, Peoples R China.
C3 Shaanxi University of Chinese Medicine; Shaanxi University of Chinese
   Medicine
RP Shi, W (corresponding author), Xian Jiao Tong Univ Xian, Med Coll, Xian 71000, Shaanxi, Peoples R China.
EM shiweijiaoda@163.com
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NR 28
TC 32
Z9 41
U1 0
U2 37
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0141-8130
EI 1879-0003
J9 INT J BIOL MACROMOL
JI Int. J. Biol. Macromol.
PD SEP
PY 2017
VL 102
BP 741
EP 748
DI 10.1016/j.ijbiomac.2017.04.091
PG 8
WC Biochemistry & Molecular Biology; Chemistry, Applied; Polymer Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Polymer Science
GA FC6XF
UT WOS:000406984300081
PM 28455258
DA 2026-05-27
ER

PT J
AU Jiang, WJ
   Zhou, R
   Li, PJ
   Sun, YL
   Lu, QF
   Qiu, Y
   Wang, JL
   Liu, JY
   Hao, K
   Ding, XS
AF Jiang, Wenjiao
   Zhou, Rui
   Li, Peijin
   Sun, Yilin
   Lu, Qianfeng
   Qiu, Yue
   Wang, Jinglei
   Liu, Jingyan
   Hao, Kun
   Ding, Xuansheng
TI Protective effect of chrysophanol on LPS/D-GalN-induced hepatic injury
   through the RIP140/NF-κB pathway
SO RSC ADVANCES
LA English
DT Article
ID ACUTE LUNG INJURY; ADJUVANT-INDUCED ARTHRITIS; INDUCED LIVER-INJURY;
   KAPPA-B PATHWAY; ELLAGIC ACID; IN-VITRO; MICE; INFLAMMATION;
   SALIDROSIDE; DAMAGE
AB Chrysophanol (Chr), one of the major anthraquinones extracted from rhubarb, has been reported to possess various pharmacological properties including anti-cancer, antimicrobial and anti-inflammatory effects. The purpose of this current study was to investigate the possible protective effects of chrysophanol for the intervention in lipopolysaccharide (LPS)/D-galactosamine (GalN)-challenged acute liver injury in mice. LPS (50 mu g kg(-1)) and D-GalN (800 mg kg(-1)) were injected intraperitoneally 1 h after chrysophanol (1.10 mg kg(-1)) pretreatment on day 7. The results demonstrated that chrysophanol showed a trend for protection against acute liver injury, as evidenced by the alleviation of hepatic pathological damage and serum ALT and AST levels, as well as the serum and hepatic production of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and IL-10. Moreover, the treatment with Chr modified the levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and glutathione peroxidase (GSH-Px) in hepatic tissues. Chrysophanol also significantly attenuated hepatic iNOS expression by inhibiting RIP140 and NF-kappa B activation, which could be observed through western blotting analysis. Simultaneously, in this present study, treatment with chrysophanol decreased the ratio of Bax/Bcl-2 and caspase-3 and caspase-8 expression, which suggested an anti-apoptotic property. Taken together, the conclusion, mirrored by our results, was that chrysophanol prevented LPS/D-GalN-induced liver injury through the induction of antioxidant defence, suppression of apoptosis and reduction of inflammatory response via inhibition of the RIP140/NF-kappa B pathway.
C1 [Jiang, Wenjiao; Li, Peijin; Sun, Yilin; Lu, Qianfeng; Hao, Kun; Ding, Xuansheng] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China.
   [Zhou, Rui; Liu, Jingyan] China Pharmaceut Univ, Dept Physiol & Pharmacol, Nanjing 210009, Jiangsu, Peoples R China.
   [Qiu, Yue; Ding, Xuansheng] China Pharmaceut Univ, Sch Pharm, Nanjing 210009, Peoples R China.
   [Wang, Jinglei] China Pharmaceut Univ, Sch Life Sci, Nanjing 210009, Peoples R China.
   [Ding, Xuansheng] China Pharmaceut Univ, Dept Clin Pharm, Nanjing 210009, Jiangsu, Peoples R China.
C3 China Pharmaceutical University; China Pharmaceutical University; China
   Pharmaceutical University; China Pharmaceutical University; China
   Pharmaceutical University
RP Hao, K; Ding, XS (corresponding author), China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China.; Ding, XS (corresponding author), China Pharmaceut Univ, Sch Pharm, Nanjing 210009, Peoples R China.
EM haokun@cpu.edu.cn; dxs0162@sina.com
RI ; zhou, rui/KZT-9353-2024; Lu, Qianfeng/PLC-0851-2026; qiu,
   yue/IAN-7956-2023
OI Li, Peijin/0000-0002-0825-2208; 
FU Natural Science Foundation of China [81302839]
FX This work was supported by the Natural Science Foundation of China
   (81302839).
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TC 46
Z9 46
U1 0
U2 39
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2046-2069
J9 RSC ADV
JI RSC Adv.
PY 2016
VL 6
IS 44
BP 38192
EP 38200
DI 10.1039/c5ra19841k
PG 9
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA DJ8WW
UT WOS:000374495400089
DA 2026-05-27
ER

PT J
AU Qi, YJ
   Cui, S
   Lu, DX
   Yang, YZ
   Luo, YS
   Ma, L
   Ma, Y
   Wuren, T
   Chang, R
   Qi, L
   Ben, BJ
   Han, J
   Ge, RL
AF Qi, Yu-juan
   Cui, Sen
   Lu, Dian-xiang
   Yang, Ying-zhong
   Luo, Yushuang
   Ma, Lan
   Ma, Yan
   Wuren, Tana
   Chang, Rong
   Qi, Lei
   Ben, Ba-ji
   Han, Jun
   Ge, Ri-Li
TI Effects of the aqueous extract of a Tibetan herb, Rhodiola algida
   var. tangutica on proliferation and HIF-1α, HIF-2α expression in
   MCF-7 cells under hypoxic condition in vitro
SO CANCER CELL INTERNATIONAL
LA English
DT Article
DE Rhodiola algida var. tangutica; MCF-7 breast cancer cell; HIF-1 alpha;
   HIF-2 alpha; Hypoxic
ID BREAST-CANCER; SALIDROSIDE; APOPTOSIS; ANGIOGENESIS; INDUCTION; CHINA
AB Ethnopharmacological relevance: Rhodiola algida var. tangutica is a traditional Tibetan herb. Its root and rhizome have been successfully used as an effective clinical remedy for the prevention and treatment of cancer and high-altitude sickness. This study aimed to investigate the effect of Rhodiola algida var. tangutica on hypoxic MCF-7 breast cancer cells and the underlying mechanisms.
   Materials and methods: The antiproliferative effects of R. algida on MCF-7 breast cancer cells were compared in vitro under hypoxic and normal conditions by using MTT analysis. The influence of R. algida on cancer cell apoptosis was determined by flow cytometry. The expression levels of hypoxia-inducible factor (HIF)-1 alpha and HIF-2 alpha were evaluated by western blot analysis.
   Results: R. algida inhibited the proliferation of MCF-7 breast cancer cells in a dose-and time-dependent manner. The results of flow cytometry indicated that the antiproliferative effect of R. algida was mediated by apoptosis induction. Pretreatment with R. algida significantly suppressed the hypoxia-induced proliferation and expression of HIF-1 alpha and HIF-2 alpha in MCF-7 breast cancer cells.
   Conclusions: R. algida might exert an anti-carcinogenic effect on MCF-7 breast cancer cells by decreasing the protein levels of HIF-1 alpha and HIF-2 alpha, which are overexpressed under hypoxic conditions. This effect might be elicited by inhibiting the hypoxia-induced proliferation of MCF-7 breast cancer cells.
C1 [Qi, Yu-juan; Chang, Rong; Ben, Ba-ji; Han, Jun] Qinghai Prov Peoples Hosp, Xining 810007, Qinghai, Peoples R China.
   [Qi, Yu-juan; Lu, Dian-xiang; Yang, Ying-zhong; Luo, Yushuang; Ma, Lan; Ma, Yan; Wuren, Tana; Qi, Lei; Ge, Ri-Li] Qinghai Univ, Res Ctr High Altitude Med, Xining 810001, Qinghai, Peoples R China.
   [Cui, Sen; Luo, Yushuang] Qinghai Univ, Affiliated Hosp, Xining 810001, Qinghai, Peoples R China.
C3 Qinghai University; Qinghai University
RP Ge, RL (corresponding author), Qinghai Univ, Res Ctr High Altitude Med, 16 Kunlun Rd, Xining 810001, Qinghai, Peoples R China.
EM geriligao@hotmail.com
RI Qi, Lei/AAC-5088-2019
FU National Basic Research Program of China [31160219]; Program of
   International S&T Cooperation of China [2011DFA32720]; National Program
   on Key Basic Research Project of China [2012CB518200]
FX This work was supported by "National Basic Research Program of China,
   No. 31160219"; Program of International S&T Cooperation of China, No.
   2011DFA32720; National Program on Key Basic Research Project of China
   (No. 2012CB518200).
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NR 28
TC 12
Z9 20
U1 1
U2 22
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1475-2867
J9 CANCER CELL INT
JI Cancer Cell Int.
PD AUG 15
PY 2015
VL 15
AR 81
DI 10.1186/s12935-015-0225-x
PG 9
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA CO8DU
UT WOS:000359396000001
PM 26279639
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Miratun, MM
   Lee, YJ
   Ngo, TH
   Kim, MJ
   Lee, JW
   Choi, H
   Han, JH
   Lee, KJ
   Nam, JW
AF Miratun, Montaha Mt.
   Lee, Yoon-Jin
   Ngo, Trung Huy
   Kim, Min Ji
   Lee, Ji Won
   Choi, Hyukjae
   Han, Jin-Hee
   Lee, Kyu Joon
   Nam, Joo-Won
TI Evaluating the cytotoxic potential of phytochemicals isolated from
   Veronica incana against DU-145 prostate cancer cells
SO FITOTERAPIA
LA English
DT Article
DE Veronica incana; Plantaginaceae; Phenolic compounds; Megastigmane
   glucoside; Iridoid glycoside; Prostate cancer
ID GLUCOSIDES; GLYCOSIDES; EFFICACY
AB Veronica incana L. (Plantaginaceae), commonly known as silver speedwell, is a flowering plant native to eastern Europe and parts of Russia, Siberia, Mongolia, and northern China. This study aimed to isolate various iridoid glycosides and other phytochemicals from the n-BuOH fraction of V. incana, resulting in the identification of one new phenolic compound (1) along with three known phenolic compounds (2: 1-O-(1-D-vanillyl-glucose, 3: isopungenin, and 4: pungenin), one tyrosol (5: salidroside), one flavonoid (6: apigenin), two megastigmane glucosides (7: [6R,9R] 3-oxo-alpha-ionol-(1-D-glucoside and 8: [6R,9S] 3-oxo-alpha-ionol-(1-D-glucoside), and ten iridoid glycosides (9: veronicoside, 10: catalposide, 11: 4 '-methoxycatalposide, 12: verproside, 13: 6-O-veratroylcatalpol, 14: 6-vanilloylcatalpol, 15: 6-O-isovanilloylcatalpol, 16: verminoside, 17: longifolioside A, and 18: dolicocymboside D). The isolation of these compounds was achieved through solvent partitioning, open-column chromatography, and semi-preparative high-performance liquid chromatography. Their structures, including absolute configurations, were determined by 1D and 2D NMR spectroscopy, optical rotation [alpha]D, and electronic circular dichroism (ECD), and confirmed by comparison with reported data. Among the isolates, compounds 2-5, 7-9, 11, 13, and 16-18 were reported for the first time from this species, while compounds 2, 7, and 8 were newly reported from the genus Veronica. Notably, compound 3 was isolated for the first time from this plant family. To evaluate their potential anticancer activity, all isolated compounds except 3, 4, and 5 were tested for antiproliferative effects against DU-145 prostate cancer cells using the MTT assay. Compounds 10 and 11 demonstrated notable inhibitory activity in this assay.
C1 [Miratun, Montaha Mt.; Ngo, Trung Huy; Choi, Hyukjae; Nam, Joo-Won] Yeungnam Univ, Coll Pharm, Gyongsan 38541, Gyeongsangbug D, South Korea.
   [Lee, Yoon-Jin] Soonchunhyang Univ, Coll Med, Dept Biochem, Cheonan Si 31151, Gyeongsangbug D, South Korea.
   [Kim, Min Ji; Lee, Ji Won; Lee, Kyu Joon] Soonchunhyang Univ, Coll Med, Dept Trop Med, Cheonan Si 31151, Chungcheongnam, South Korea.
   [Choi, Hyukjae] Yeungnam Univ, Res Inst Cell Culture, Gyongsan 38541, Gyeongsangbug D, South Korea.
   [Han, Jin-Hee] Kangwon Natl Univ, Sch Med, Dept Med Environm Biol & Trop Med, Chuncheon Si 24341, Gangwon Do, South Korea.
C3 Yeungnam University; Soonchunhyang University; Soonchunhyang University;
   Yeungnam University; Kangwon National University
RP Nam, JW (corresponding author), Yeungnam Univ, Coll Pharm, Gyongsan 38541, Gyeongsangbug D, South Korea.; Lee, KJ (corresponding author), Soonchunhyang Univ, Coll Med, Dept Trop Med, Cheonan Si 31151, Chungcheongnam, South Korea.
EM kjl07@sch.ac.kr; jwnam@yu.ac.kr
OI Montaha, Mt. Miratun/0009-0003-1414-9076; Huy Ngo,
   Trung/0000-0002-5253-363X
FU National Research Foundation of Korea (NRF) - Ministry of Science and
   ICT (MSIT) [RS-2022-NR069508, RS-2025-00518392]; Korea Basic Science
   Institute - Ministry of Education [RS-2025-02317758]
FX This research was supported by the National Research Foundation of Korea
   (NRF) , funded by the Ministry of Science and ICT (MSIT) (grant No.
   RS-2022-NR069508, RS-2025-00518392) . Additionally, this was also
   supported by Korea Basic Science Institute (National Research
   Fa-cilities and Equipment Center) grant funded by the Ministry of
   Education (RS-2025-02317758) .
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NR 23
TC 0
Z9 0
U1 1
U2 1
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0367-326X
EI 1873-6971
J9 FITOTERAPIA
JI Fitoterapia
PD JAN
PY 2026
VL 188
AR 107015
DI 10.1016/j.fitote.2025.107015
EA DEC 2025
PG 5
WC Chemistry, Medicinal; Integrative & Complementary Medicine; Pharmacology
   & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Integrative & Complementary Medicine
GA R3184
UT WOS:001635471800001
PM 41338396
DA 2026-05-27
ER

PT J
AU Li, XJ
   Mu, YT
   Wang, JJ
   Zhang, XM
AF Li, Xiaojie
   Mu, Yingtong
   Wang, Junjie
   Zhang, Xiaoming
TI Weighted Correlation Network Analysis Mining Key Metabolites and Genes
   for Regulation of Root Growth and Secondary Metabolism of Astragalus
   membranaceus mongholicus
SO LEGUME RESEARCH
LA English
DT Article
DE Astragalus; Hub gene and metabolite; Secondary metabolism; WGCNA
AB Background: Harvesting period is an important feature that not only affects the yield quality of Astragalus herbs but also the content of astragaloside IV and calycosin 7-O-beta-D-glucopyranoside which are considered as the core indicators of the quality of Astragalus herbs. Herb yield and quality undergo rapid and substantial changes during the harvesting process. Part of enzymes and their encoding genes have been identified as potential candidates for the biosynthesis of herb quality-related triterpenoid saponins and isoflavonoids. However, wide gap still exists in the understanding of the pathways involving growth, development and biosynthesis of these two important active components in the roots of Astragalus. Methods: In this study, we used Astragalus roots as material to analyze its metabolome and transcriptome of herbs at harvesting stage. Result: The results indicated that changes in the harvesting period had a significant effect on the yield and quality of the herbs. Correlation of metabolome and RNA-seq results constructed using weighted gene co-expression network analysis (WGCNA) with herb growth and development indicated that the expression patterns of 19 hub metabolites (Oxamniquine, 4-ene-Valproic acid, Traumatic Acid, L-Histidinol, Salidroside, Temsavir, Retaspimycin, Isosakuranetin, etc.) and 16 structural genes with annotations (CNX2, talA, ABCF2, HIBCH, crtZ, etc.) had the highest connectivity with root growth and secondary metabolism of Astragalus. To search for potential regulatory genes related to root growth and development, we screened 54 relevant genes using 16 hub genes with annotations. The results advance the molecular basis of biosynthesis of secondary metabolites related to the harvesting period of Astragalus herbs, which can provide a theoretical basis for determining the regulatory mechanism of yield and quality.
C1 [Li, Xiaojie; Mu, Yingtong; Wang, Junjie; Zhang, Xiaoming] Inner Mongolia Agr Univ, Key Lab Grassland Resources, Coll Grassland Resource & Environm Sci, Minist Educ, Hohhot 010021, Peoples R China.
   [Li, Xiaojie; Mu, Yingtong; Wang, Junjie; Zhang, Xiaoming] Engn Res Ctr Seed breeding Chinese & Mongolian Med, Hohhot 010011, Inner Mongolia, Peoples R China.
C3 Inner Mongolia Agricultural University
RP Zhang, XM (corresponding author), Inner Mongolia Agr Univ, Key Lab Grassland Resources, Coll Grassland Resource & Environm Sci, Minist Educ, Hohhot 010021, Peoples R China.
EM bagenna123@aliyun.com
FU Scientifc and Technological Achievements Transformation Project of Inner
   Mongolia Autonomous Region [2022YFDZ0025, CGZH2018134]
FX Xiaojie Li and Xiaoming Zhang designed the experiments. Xiaojie Li and
   Yingtong Mu conducted the experiments. Xiaojie Li wrote the manuscript.
   Junjie Wang and Xiaoming Zhang reviewed the manuscript. All authors
   approved the paper. All co-authors reviewed the final version and
   approved the manuscript before submission. This work was supported by a
   grant from "Identifcation of high yielding and-quality germplasm and
   breeding technology of Astragalus Membranaceus Mongholicus"
   (2023-Society-2) , "Efcient Breeding and Processing Technology
   Integration of Multifunctional Grass Seeds for Grassland" (2022YFDZ0025)
   and "Scientifc and Technological Achievements Transformation Project of
   Inner Mongolia Autonomous Region" (CGZH2018134) .
CR Chen Y, 2023, PLANT COMMUN, V4, DOI 10.1016/j.xplc.2022.100469
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   Xie N, 2024, BMC PLANT BIOL, V24, DOI 10.1186/s12870-024-04949-1
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NR 22
TC 0
Z9 0
U1 1
U2 10
PU AGRICULTURAL RESEARCH COMMUNICATION CENTRE
PI KARNAL
PA 1130 SADAR BAZAR, POST OFFICE MARG, KARNAL 132 001, INDIA
SN 0250-5371
J9 LEGUME RES
JI Legume Res.
PD JAN
PY 2025
VL 48
IS 1
BP 47
EP 56
DI 10.18805/LRF-824
PG 10
WC Agronomy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture
GA W0B8I
UT WOS:001415345400007
OA hybrid
DA 2026-05-27
ER

PT J
AU Kotsupiy, OV
   Achimova, AA
   Zhmud, EV
   Williams, N
   Kuban, IN
   Dorogina, OV
   Khramova, EP
AF V. Kotsupiy, Olga
   Achimova, Altynai A. .
   V. Zhmud, Elena
   Williams, Natasha
   Kuban, Irina N.
   V. Dorogina, Olga
   Khramova, Elena P.
TI Secondary metabolites in rhizomes of wild Rhodiola rosea representatives
   from various ecological and geographical conditions in the Altai
   Mountains
SO BIOCHEMICAL SYSTEMATICS AND ECOLOGY
LA English
DT Article
DE Phenylpropanoids; Cenopopulations; Individual variability; Phenolic
   compounds content
ID PHENYLPROPENOID CONTENT; HARVEST SEASON; PERFORMANCE; PART
AB The purpose of this study is to identify the most productive cenopopulations (CP) of the rare species Rhodiola rosea based on the accumulation of biologically active compounds in the rhizomes in 14 CP from different ecological and geographical conditions of Altai Mountains. The composition and content of 11 components, including salidroside, tyrosol, (+)-catechin, epigallocatechin gallate, rosarin, rosavin, rosin, cinnamyl alcohol, rhodiosin, and rhodionin, were determined by HPLC analysis. The composition of phenolic compounds (PC) in the studied CPs of R. rosea was stable. The amounts of each of the 11 components of the PC and groups of compounds were different in the CPs from different ecological and geographical conditions. The highest and lowest levels of phenylpropanoids (PP) were found in individuals from the Ust-Kan region. These are CP1, from the Baschelaksky ridge, 2000 m above sea level (masl), and CP7 in the Talkash River valley, 1200 m above sea level (4613.1 +/- 170.1 and 1362.0 +/- 57.0 mg/100 g, respectively). The highest content of PP was found in the samples from seven CPs. Of these, 60% grew in the milder climatic conditions (Ust-Kan region). In terms of individual variability in PC content in two model CPs of R. rosea, a significantly higher content of most PC groups was found in the representatives from more stressful high-mountain conditions (2000 masl) in alpine zone, compared with the same indicators in plants growing at lower altitude in forest zone (1500 masl) (classification of N.I. Makunina, 2016). Selection of the most productive forms of this valuable medicinal species would allow for their in vitro introduction and micropropagation into the culture.
C1 [V. Kotsupiy, Olga; V. Zhmud, Elena; Kuban, Irina N.; V. Dorogina, Olga; Khramova, Elena P.] RAS, Cent Siberian Bot Garden, SB, Zolotodolinskaya Str 101, Novosibirsk 630090, Russia.
   [Achimova, Altynai A. .] Gorno Altai Bot Garden, Kamlak 649218, Russia.
   [Williams, Natasha] Colorado State Univ, Dept Food Sci & Human Nutr, 502 Lake St, Ft Collins, CO 80523 USA.
   [V. Dorogina, Olga] Novosibirsk State Univ, NSU Climate Ctr, Pirogova Str 1, Novosibirsk 630090, Russia.
C3 Russian Academy of Sciences; Siberian Branch of the Russian Academy of
   Sciences; Central Siberian Botanical Garden; Colorado State University
   System; Colorado State University Fort Collins; Novosibirsk State
   University
RP Kotsupiy, OV (corresponding author), RAS, Cent Siberian Bot Garden, SB, Zolotodolinskaya Str 101, Novosibirsk 630090, Russia.
EM botgard@csbg-nsk.ru
RI Zhmud, Elena/P-8138-2016; Kotsupii, Olga/I-3732-2018; Khramova,
   Elena/K-5497-2017; dorogina, olga/AAJ-5429-2021; , Ольга/I-3732-2018
OI , Ольга/0000-0002-5326-4371
FU NSU Climate Center (Novosibirsk State University Russia)
   [FSUS-2023-0003]
FX The work was conducted within the framework of the state task of the
   Central Siberian Botanical Garden of the Siberian Branch of the Russian
   Academy of Sciences, Russia "Analysis of biodiversity, conservation and
   restoration of rare and resource plant species using experimental
   methods" (AAAA-A21-121011290025-2) and with the financial support of
   project of the NSU Climate Center (Novosibirsk State University Russia)
   "Ecosystems of herbaceous pine and small-leaved forests as regulators of
   nitrogen and carbon balance in the forest-steppe landscape of Western
   Siberia" (FSUS-2023-0003).
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   Brinckmann JA, 2021, J ETHNOPHARMACOL, V269, DOI 10.1016/j.jep.2020.113710
   Cunningham AB, 2020, J ETHNOPHARMACOL, V252, DOI 10.1016/j.jep.2019.112379
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NR 32
TC 2
Z9 4
U1 2
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0305-1978
EI 1873-2925
J9 BIOCHEM SYST ECOL
JI Biochem. Syst. Ecol.
PD OCT
PY 2024
VL 116
AR 104860
DI 10.1016/j.bse.2024.104860
EA JUN 2024
PG 8
WC Biochemistry & Molecular Biology; Ecology; Evolutionary Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Environmental Sciences & Ecology;
   Evolutionary Biology
GA XA8J6
UT WOS:001259048900001
DA 2026-05-27
ER

PT J
AU Lewicki, S
   Stankiewicz, W
   Skopinska-Rózewska, E
   Wilczak, J
   Lesniak, M
   Suska, M
   Siwicki, AK
   Skopinski, P
   Zdanowski, R
AF Lewicki, S.
   Stankiewicz, W.
   Skopinska-Rozewska, E.
   Wilczak, J.
   Lesniak, M.
   Suska, M.
   Siwicki, A. K.
   Skopinski, P.
   Zdanowski, R.
TI Spleen content of selected polyphenols, splenocytes morphology and
   function in mice fed Rhodiola kirilowii extracts during pregnancy
   and lactation
SO POLISH JOURNAL OF VETERINARY SCIENCES
LA English
DT Article
DE mouse; pregnancy; Rhodiola kirilowii; polyphenols; spleen; lymphcytes
ID CELLULAR-IMMUNITY; EPIGALLOCATECHIN GALLATE; MOUSE BLASTOCYSTS; RATS;
   QUERCETIN; CATECHIN; SALIDROSIDE; FLAVONOIDS; CELLS; PROLIFERATION
AB The genus Rhodiola (Crassulaceae) consists of many species, growing mainly in Asia and traditionally used as adaptogens and anti-inflammatory drugs. In order to elaborate herbal immunostimulator which could be safely given to pregnant women, we performed a study on immunotropic effects of feeding pregnant and lactating mice Rhodiola kirilowii extracts. This paper presents the results of the first part of our study spleen content of selected polyphenols, spleen cellularity, splenocytes phenotype and their response to mitogens. Experiments were performed on adult inbred females of Balb/c strain, mated with adult males. Females, since copulatory plug was noted, up to the 28-th day after delivery were fed daily with 20 mg/kg b.m. water (RKW) or hydro-alcoholic (RKW-A) extracts of Rhodiola kirilowii. Results: 1. Significantly lower proportion of pregnant mice in experimental groups than in the control. 2. Cellularity of spleen and flavonol quercetin spleen concentration were significantly lower in experimental groups in comparison to the controls. 3. Flavanols ((+)-catechin and epicatechin) levels were significantly higher in the spleens of experimental mice than in the controls. 4. Positive correlation between spleen cellularity and quercetin, and negative correlation between spleen cellularity and epicatechin content were observed. 5. Spleen mass and spleen lymphocytes phenotype and proliferation in RKW and RKW-A fed mice did not differ from the control. These results, together with suspicion of some embryo-toxicity, are worrying and eliminate the possibility of use Rhodiola kirilowii extracts for long-term treatment in pregnant females.
C1 [Lewicki, S.; Lesniak, M.; Suska, M.; Zdanowski, R.] Mil Inst Hyg & Epidemiol, Dept Regenerat Med, PL-01163 Warsaw, Poland.
   [Stankiewicz, W.] Mil Inst Hyg & Epidemiol, Dept Microwave Safety, PL-01163 Warsaw, Poland.
   [Skopinska-Rozewska, E.] Med Univ Warsaw, Dept Pathol, Ctr Biostruct Res, PL-02004 Warsaw, Poland.
   [Wilczak, J.] Warsaw Univ Life Sci, Fac Vet Med, Dept Physiol Sci, PL-02787 Warsaw, Poland.
   [Siwicki, A. K.] Univ Warmia & Mazury, Dept Microbiol & Clin Immunol, PL-10957 Olsztyn, Poland.
   [Skopinski, P.] Med Univ Warsaw, Dept Histol & Embryol, Ctr Biostruct Res, PL-02004 Warsaw, Poland.
C3 Military Institute of Hygiene & Epidemiology (MIHE); Military Institute
   of Hygiene & Epidemiology (MIHE); Medical University of Warsaw; Warsaw
   University of Life Sciences; University of Warmia & Mazury; Medical
   University of Warsaw
RP Lewicki, S (corresponding author), Mil Inst Hyg & Epidemiol, Dept Regenerat Med, Kozielska 4, PL-01163 Warsaw, Poland.
EM lewickis@gmail.com
RI ; Lewicki, Sławomir/AAZ-4709-2020
OI Zdanowski, Robert/0000-0003-0455-1072; Lewicki,
   Sławomir/0000-0002-0539-0680; Skopiński, Piotr/0000-0001-5794-9346;
   Leśniak, Monika/0000-0003-0340-4054; Wilczak, Jacek/0000-0002-3053-3663
FU National Science Center (Poland) [2012/05/B/NZ7/03219]
FX The study was supported by National Science Center (Poland) grant No.:
   2012/05/B/NZ7/03219.
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NR 35
TC 15
Z9 17
U1 0
U2 18
PU POLSKA AKAD NAUK, POLISH ACAD SCIENCES, UNIV WARMIA & MAZURY OLSZTYN
PI WARSZAWA
PA PL DEFILAD 1, WARSZAWA, 00-901, POLAND
SN 1505-1773
EI 2300-2557
J9 POL J VET SCI
JI Pol. J. Vet. Sci.
PY 2015
VL 18
IS 4
BP 847
EP 855
DI 10.1515/pjvs-2015-0110
PG 9
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA CZ2UV
UT WOS:000366961000024
PM 26812829
OA Bronze
DA 2026-05-27
ER

PT J
AU Cybulska, P
   Thakur, SD
   Foster, BC
   Scott, IM
   Leduc, RI
   Arnason, JT
   Dillon, JAR
AF Cybulska, Paulina
   Thakur, Sidharath D.
   Foster, Brian C.
   Scott, Ian M.
   Leduc, Renee I.
   Arnason, John T.
   Dillon, Jo-Anne R.
TI Extracts of Canadian First Nations Medicinal Plants, Used as Natural
   Products, Inhibit Neisseria gonorrhoeae Isolates With Different
   Antibiotic Resistance Profiles
SO SEXUALLY TRANSMITTED DISEASES
LA English
DT Article
ID STAPHYLOCOCCUS-AUREUS; HYDRASTIS-CANADENSIS; OCIMUM-SANCTUM; ARBUTIN
AB Background: Neisseria gonorrhoeae (Ng) has developed resistance to most antimicrobial agents and the antibiotics recommended for therapy are restricted, for the most part, to third generation cephalosporins. In order to investigate new potential sources of antimicrobial agents, the antibacterial properties of 14 Canadian plants used in traditional First Nations' medicine were tested against Ng isolates having differing antimicrobial susceptibility profiles.
   Methods: Ethanolic extracts of 14 Canadian botanicals, analyzed by high-performance liquid chromatography, were tested for their antimicrobial activity (disc diffusion and/or agar dilution assays) against susceptible Ng reference strains and a panel of 28 Ng isolates with various antimicrobial resistance profiles.
   Results: Extracts of Arctostaphylos uva ursi (kinnikinnick or bearberry), Hydrastis canadensis (goldenseal), Prunus serotina (black cherry), and Rhodiola rosea (roseroot) inhibited the growth of all Ng isolates with minimum inhibitory concentrations of 32 mu g/mL, 4 to 32 mu g/mL, 16 to >32 mu g/mL, and 32 to 64 mu g/mL, respectively. Extracts of Acorus americanus (sweet flag), Berberis vulgaris (barberry), Cimicifuga racemosa (black cohosh), Equisetum arvense (field horsetail), Gaultheria procumbens (wintergreen), Ledum groenlandicum (Labrador tea), Ledum palustre (marsh Labrador tea), Oenothera biennis (common evening primrose), Sambucus nigra (elderberry), and Zanthoxylum americanum (prickly ash) had weak or no antimicrobial activity against the Ng isolates with minimum inhibitory concentrations >= 256 mu g/mL. The phytochemical berberine from H. canadensis inhibited the growth of all Ng isolates. The phytochemicals, salidroside and rosavin, present in R. rosea, also showed inhibitory activity against Ng strains.
   Conclusion: Canadian botanicals represent a potential source of novel compounds which inhibit Ng, including isolates resistant to antibiotics.
C1 [Cybulska, Paulina; Foster, Brian C.; Scott, Ian M.; Leduc, Renee I.; Arnason, John T.; Dillon, Jo-Anne R.] Univ Ottawa, Dept Biol, Ottawa, ON, Canada.
   [Thakur, Sidharath D.; Dillon, Jo-Anne R.] Univ Saskatchewan, Vaccine & Infect Dis Org, Saskatoon, SK, Canada.
C3 University of Ottawa; University of Saskatchewan
RP Dillon, JAR (corresponding author), Rm A218,120 Vet Rd, Saskatoon, SK S7N 5E3, Canada.
EM j.dillon@usask.ca
RI Scott, Ian/AAA-2538-2021; Arnason, John/GXM-3860-2022
OI Scott, Ian/0000-0002-1972-6616; 
FU Health Canada
FX Supported by Health Canada (to B.C.F., J.R.D.).
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NR 28
TC 30
Z9 36
U1 1
U2 65
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-5717
EI 1537-4521
J9 SEX TRANSM DIS
JI Sex. Transm. Dis.
PD JUL
PY 2011
VL 38
IS 7
BP 667
EP 671
DI 10.1097/OLQ.0b013e31820cb166
PG 5
WC Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases
GA 777BD
UT WOS:000291586900016
PM 21301385
DA 2026-05-27
ER

PT J
AU Liu, HY
   Xiao, QJ
   Wu, XX
   Ma, H
   Li, J
   Guo, XF
   Liu, ZY
   Zhang, Y
   Luo, YZ
AF Liu, Huayi
   Xiao, Qingjie
   Wu, Xinxin
   Ma, He
   Li, Jian
   Guo, Xufan
   Liu, Zhenyu
   Zhang, Yan
   Luo, Yunzi
TI Mechanistic investigation of a D to N mutation in DAHP synthase that
   dictates carbon flux into the shikimate pathway in yeast
SO COMMUNICATIONS CHEMISTRY
LA English
DT Article
ID 3-DEOXY-D-ARABINO-HEPTULOSONATE-7-PHOSPHATE SYNTHASE; INHIBITION;
   COMPLEXES; GENE
AB 3-Deoxy-D-arabino-heptulosonate-7-phosphate synthase (DAHPS) is a key enzyme in the shikimate pathway for the biosynthesis of aromatic compounds, however, its activity is inhibited by L-Phe and L-Tyr. Here, the authors report the D154N point mutation of yeast DAHPS, which retains the wild type enzyme activity but relieves the inhibition by L-Phe, thus increasing the production of downstream aromatic amino acid derivatives.
   3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (DAHPS) is a key enzyme in the shikimate pathway for the biosynthesis of aromatic compounds. (L)-Phe and (L)-Tyr bind to the two main DAHPS isoforms and inhibit their enzyme activities, respectively. Synthetic biologists aim to relieve such inhibitions in order to improve the productivity of aromatic compounds. In this work, we reported a point mutant of yeast DHAPS, Aro3(D154N), which retains the wild type enzyme activity but converts it highly inert to the inhibition by (L)-Phe. The Aro3 crystal structure along with the molecular dynamics simulations analysis suggests that the D154N mutation distant from the inhibitor binding cavity may reduce the binding affinity of (L)-Phe. Growth assays demonstrated that substitution of the conserved D154 with asparagine suffices to relieve the inhibition of (L)-Phe on Aro3, (L)-Tyr on Aro4, and the inhibitions on their corresponding homologues from diverse yeasts. The importance of our discovery is highlighted by the observation of 29.1% and 43.6% increase of yield for the production of tyrosol and salidroside respectively upon substituting ARO3 with ARO3(D154N). We anticipate that this allele would be used broadly to increase the yield of various aromatic products in metabolically diverse microorganisms.
C1 [Liu, Huayi; Wu, Xinxin; Ma, He; Li, Jian; Guo, Xufan; Liu, Zhenyu; Luo, Yunzi] Tianjin Univ, Frontiers Sci Ctr Synthet Biol, Tianjin 300072, Peoples R China.
   [Liu, Huayi; Wu, Xinxin; Ma, He; Li, Jian; Guo, Xufan; Liu, Zhenyu; Luo, Yunzi] Tianjin Univ, Sch Chem Engn & Technol, Key Lab Syst Bioengn, Minist Educ, Tianjin 300072, Peoples R China.
   [Liu, Huayi; Luo, Yunzi] Tianjin Univ, Georgia Tech Shenzhen Inst, Tangxing Rd 133, Shenzhen 518071, Peoples R China.
   [Xiao, Qingjie] Chinese Acad Sci, Shanghai Adv Res Inst, Zhangjiang Lab, Natl Facil Prot Sci Shanghai, Shanghai 201210, Peoples R China.
   [Zhang, Yan] Tianjin Univ, Collaborat Innovat Ctr Chem Sci & Engn, Sch Pharmaceut Sci & Technol, Tianjin Key Lab Modern Drug Delivery & High Effici, Tianjin 300072, Peoples R China.
C3 Tianjin University; Tianjin University; Tianjin University; Chinese
   Academy of Sciences; Shanghai Advanced Research Institute, CAS;
   Zhangjiang Laboratory; Nankai University; Tianjin University;
   Collaborative Innovation Center of Chemical Science & Engineering
   Tianjin
RP Luo, YZ (corresponding author), Tianjin Univ, Frontiers Sci Ctr Synthet Biol, Tianjin 300072, Peoples R China.; Luo, YZ (corresponding author), Tianjin Univ, Sch Chem Engn & Technol, Key Lab Syst Bioengn, Minist Educ, Tianjin 300072, Peoples R China.; Luo, YZ (corresponding author), Tianjin Univ, Georgia Tech Shenzhen Inst, Tangxing Rd 133, Shenzhen 518071, Peoples R China.
EM yunzi.luo@tju.edu.cn
RI ; Liu, Huayi/KCK-1825-2024; Zhang, Yan/K-1638-2015; Luo,
   Yunzi/L-1290-2018
OI Wu, Xinxin/0009-0005-9342-0964; Liu, Huayi/0000-0001-5179-1912; Zhang,
   Yan/0000-0003-2031-0631; Luo, Yunzi/0000-0002-5860-6350; Li,
   Jian/0000-0002-3167-4265
FU National Key Research and Development Program of China [2018YFA0903300];
   National Natural Science Foundation of China [32071426]; Key-Area
   Research and Development Program of Guangdong Province [2020B0303070002]
FX AcknowledgementsThe work was supported by the National Key Research and
   Development Program of China (Grant No. 2018YFA0903300), the National
   Natural Science Foundation of China (Grant No. 32071426), and the
   Key-Area Research and Development Program of Guangdong Province
   (2020B0303070002).
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NR 40
TC 31
Z9 37
U1 5
U2 70
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2399-3669
J9 COMMUN CHEM
JI Comm. Chem.
PD JUL 15
PY 2023
VL 6
IS 1
AR 152
DI 10.1038/s42004-023-00946-x
PG 10
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA L8SM7
UT WOS:001025908000001
PM 37454208
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhu, T
   Wang, L
   Wang, LP
   Wan, Q
AF Zhu, Ting
   Wang, Lei
   Wang, Li-ping
   Wan, Qi
TI Therapeutic targets of neuroprotection and neurorestoration in ischemic
   stroke: Applications for natural compounds from medicinal herbs
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Review
DE Ischemic stroke; Neuroprotection; Neurorestoration; Traditional Chinese
   medicine (TCM)
ID ENDOTHELIAL GROWTH-FACTOR; FOCAL CEREBRAL-ISCHEMIA; SALVIANOLIC ACID B;
   OXYGEN-GLUCOSE DEPRIVATION/REOXYGENATION; RESVERATROL PROVIDES
   NEUROPROTECTION; BLOOD-BRAIN-BARRIER; NF-KAPPA-B; OXIDATIVE STRESS;
   NITRIC-OXIDE; ISCHEMIA/REPERFUSION INJURY
AB Neuroprotective and neurorestorative therapy represent two major drug intervention strategies for ischemic stroke. Multiple factors such as excitotoxicity, inflammation, angiogenesis, and neurogenesis are the main pathological processes that underlie acute and chronic ischemic brain injury. Furthermore, their intimate interactions mediate blood-brain barrier permeability, increase neurovascular unit structural damage as well as a hemorrhagic transformation during ischemic stroke. We aimed to review the current understandings of the underlying mechanisms of neuroprotection and neurorestoration in ischemic stroke. Notably, traditional Chinese medicine (TCM) has notable advantages in the comprehensive treatment and overall regulation of multi-site and multi-target diseases. Therefore, we reviewed the recent advances in natural compounds from medicinal herbs that possess the bioactivities of simultaneously promoting neuroprotection (e.g., excitotoxicity, oxidative stress, apoptosis, inflammation, and autophagy) and neurorestoration (e.g., angiogenesis, neurogenesis, and axonal sprouting) following brain ischemia injury. These natural compounds were divided into glycosides (astragaloside IV, gastrodin, ginsenoside Rg1 and salidroside), flavonoids (baicalin, icariin, puerarin and breviscapine), phenols (resveratrol, curcumin and salvianolic acid B), and terpenes (ginkgolide B and catalpol). We found that all compounds exhibited anti-brain ischemia activities in vivo and in vitro experiments by promoting neuroprotection and, or neurorestoration. This review tracks and summarizes the progress of the past five years to explore the active compounds and the underlying molecular mechanisms of TCMs that produce proneuroprotection and pro-neurorestoration. Additionally, we provide another basis of reference supporting the advantages of TCMs, which could ultimately lead to the development of precise clinical medications for ischemic stroke treatment.
C1 [Zhu, Ting; Wan, Qi] Qingdao Univ, Inst Neuroregenerat & Neurorehabil, Sch Basic Med, Dept Pathophysiol, Qingdao 266071, Peoples R China.
   [Wang, Lei] China Pharmaceut Univ, Nanjing 211198, Peoples R China.
   [Wang, Li-ping] Qingdao Women & Childrens Hosp, Dept Pharm, Qingdao 266000, Peoples R China.
C3 Qingdao University; China Pharmaceutical University
RP Wan, Q (corresponding author), Qingdao Univ, Inst Neuroregenerat & Neurorehabil, Sch Basic Med, Dept Pathophysiol, Qingdao 266071, Peoples R China.
EM linlang0402@foxmail.com; wangleiEric@163.com; wang123liping123@163.com;
   qiwan1@hotmail.com
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NR 198
TC 248
Z9 274
U1 32
U2 354
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD APR
PY 2022
VL 148
AR 112719
DI 10.1016/j.biopha.2022.112719
EA FEB 2022
PG 19
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA ZF6AF
UT WOS:000759647700010
PM 35168073
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Yu, JQ
   Sun, XW
   Zhao, L
   Wang, XY
   Wang, X
AF Yu, Jinqian
   Sun, Xiaowei
   Zhao, Lei
   Wang, Xueyong
   Wang, Xiao
TI An efficient method to obtain anti-inflammatory phenolic derivatives
   from Scindapsus officinalis (Roxb.) Schott. by a high speed
   counter-current chromatography coupled with a recycling mode
SO RSC ADVANCES
LA English
DT Article
ID LIQUID-LIQUID-EXTRACTION; CHROMONE GLYCOSIDES; PREPARATIVE SEPARATION;
   GINKGOLIC ACIDS; SOLVENT SYSTEM; SARCOTESTA
AB Herein, we provide an effective separation strategy based on liquid-liquid extraction and two different modes of high speed counter-current chromatography (HSCCC) for the rapid enrichment and separation of compounds from n-butanol-partitioned samples of S. officinalis. Liquid-liquid extraction of the crude sample was performed using a two-phase solvent system composed of ethyl acetate-n-butanol-water with volume ratios of 9 : 0 : 9, 5 : 4 : 9 and 3 : 6 : 9 (v/v), which allowed components with lower polarity and higher polarity to be enriched separately with the first ratio and the other two ratios, respectively. For separation, the conventional and recycling mode HSCCC were combined to develop a strategy for the acquisition of eight phenolic derivatives from the enriched samples, including one new compound, 7-O-[beta-d-xylopyranosyl-(1-4)-beta-d-glucopyranosyl-(1-4)-alpha-l-rhamnopyranosyl]-5-hydroxy-2-methyl-4H-1-benzopyran-4-one (5), three caffeoylquinic acid isomers, 3-O-caffeoylquinic acid butyl ester (6), 5-O-caffeoylquinic acid butyl ester (7), 4-O-caffeoylquinic acid butyl ester (8), salidroside (1), drynachromoside B (2), 3,4-dihydroxy-benzoic acid (3), and 5,7-dihydroxy-2-methyl chromone (4). Recycling HSCCC separation was successfully applied to separate the three isomers after six cycles. Furthermore, all the isolates were evaluated for their anti-inflammatory activity against nitric oxide (NO) production in vitro, with 6 and 7 showing significant inhibitory effects with IC50 values of 13.8 mu M and 17.6 mu M, respectively.
C1 [Yu, Jinqian; Sun, Xiaowei; Wang, Xiao] Qilu Univ Technol, Shandong Acad Sci, Shandong Anal & Test Ctr, Shandong Key Lab TCM Qual Control Technol, Jinan 250014, Peoples R China.
   [Zhao, Lei] Reyoung Pharmaceut Co Ltd, 44 Cultural West Rd, Jinan 250012, Peoples R China.
   [Wang, Xueyong] Beijing Univ Chinese Med, Coll Chinese Mat Med, Beijing 100102, Peoples R China.
C3 Qilu University of Technology; Beijing University of Chinese Medicine
RP Wang, X (corresponding author), Qilu Univ Technol, Shandong Acad Sci, Shandong Anal & Test Ctr, Shandong Key Lab TCM Qual Control Technol, Jinan 250014, Peoples R China.; Wang, XY (corresponding author), Beijing Univ Chinese Med, Coll Chinese Mat Med, Beijing 100102, Peoples R China.
EM xueyongwang@bucm.edu.cn; wangx@sdas.org
RI wang, xiao/HGB-7081-2022
FU Shandong Provincial Natural Science Foundation [ZR2018QH006]; Shandong
   Provincial Key Research and Development Plan [2019GSF108004]; National
   Key R&D Program of China [2017YFC1700703, 2017YFC1702701]; Priority
   Research Program of the Shandong Academy of Sciences
FX This work was supported by Shandong Provincial Natural Science
   Foundation (ZR2018QH006), Shandong Provincial Key Research and
   Development Plan (2019GSF108004), the National Key R&D Program of China
   (2017YFC1700703, 2017YFC1702701) and the Priority Research Program of
   the Shandong Academy of Sciences.
CR Chen T, 2018, J SEP SCI, V41, DOI 10.1002/jssc.201800411
   Han LF, 2015, NAT PROD RES, V29, P1703, DOI 10.1080/14786419.2014.998216
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   Liu Q, 2015, FOOD CHEM, V186, P139, DOI 10.1016/j.foodchem.2014.09.037
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NR 23
TC 13
Z9 13
U1 0
U2 14
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
EI 2046-2069
J9 RSC ADV
JI RSC Adv.
PD MAR 19
PY 2020
VL 10
IS 19
BP 11132
EP 11138
DI 10.1039/c9ra09453a
PG 7
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA LA0II
UT WOS:000523640500017
PM 35495326
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Coors, A
   Brosch, M
   Kahl, E
   Khalil, R
   Michels, B
   Laub, A
   Franke, K
   Gerber, B
   Fendt, M
AF Coors, Andreas
   Brosch, Marcel
   Kahl, Evelyn
   Khalil, Radwa
   Michels, Birgit
   Laub, Annegret
   Franke, Katrin
   Gerber, Bertram
   Fendt, Markus
TI Rhodiola rosea root extract has antipsychotic-like effects in
   rodent models of sensorimotor gating
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Apomorphine; Dizocilpine; Mice; MK-801; Prepulse inhibition; Rats;
   Rhodiola rosea L.; Startle response
ID PREPULSE INHIBITION DEFICITS; ACOUSTIC STARTLE; ANIMAL-MODELS;
   DOUBLE-BLIND; SCHIZOPHRENIA; STRESS; HABITUATION; ADAPTOGENS;
   SALIDROSIDE; MECHANISMS
AB Ethnopharmacological relevance: The plant arctic root (Rhodiola rosea, L.) is growing in northern regions of Europe, Asia and North America. Extracts of R. rosea are used in traditional medicine for various conditions related to nervous system function. According to scientific studies from the last decades, the plant might have potential for use in the treatment of memory impairments, stress and depression, but reports concerning other neuropsychiatric disorders are scarce.
   Aim of the study: In this context, our study aimed to examine potential antipsychotic-like effects of R. rosea root extract.
   Materials and methods: We tested the effects of R. rosea root extract on prepulse inhibition in rats and mice. Prepulse inhibition is an established operational measure of sensorimotor gating, which is impaired in schizophrenia and other psychotic disorders.
   Results: R. rosea root extract increased prepulse inhibition in rats and mice. Interestingly, the R. rosea extract had stronger effects in those individual animals that had low baseline levels of prepulse inhibition. Therefore, we performed further experiments in which we pharmacologically induced a prepulse inhibition deficit by two different psychostimulants, either the dopamine D2 receptor agonist apomorphine or the NMDA receptor antagonist dizocilpine (MK-801). Pre-treatment with the R. rosea extract significantly restored both, apomorphine-and dizocilpine-induced prepulse inhibition deficits.
   Conclusions: The present study demonstrates that R. rosea extract robustly reverses prepulse inhibition deficits in rodents. This suggests antipsychotic-like effects of R. rosea extract. Future studies should focus on the pharmacological mechanisms underlying these effects.
C1 [Coors, Andreas] Univ Bremen, Neurosci Program, Bremen, Germany.
   [Coors, Andreas; Kahl, Evelyn; Khalil, Radwa; Fendt, Markus] Otto von Guericke Univ, Inst Pharmacol & Toxicol, Leipziger Str 44, D-39120 Magdeburg, Germany.
   [Brosch, Marcel] Otto von Guericke Univ, Integrat Neurosci Program, Magdeburg, Germany.
   [Michels, Birgit; Gerber, Bertram] Leibniz Inst Neurobiol, Genet, Magdeburg, Germany.
   [Gerber, Bertram] Otto von Guericke Univ, Inst Biol, Magdeburg, Germany.
   [Gerber, Bertram; Fendt, Markus] Otto von Guericke Univ, Ctr Behav Brain Sci, Magdeburg, Germany.
   [Laub, Annegret; Franke, Katrin] Leibniz Inst Plant Biochem, Halle, Germany.
   [Coors, Andreas] Univ Bremen, Ctr Cognit Sci, Dept Neuropharmacol, Bremen, Germany.
   [Brosch, Marcel] Leibniz Inst Neurosci, Syst Physiol Learning, Magdeburg, Germany.
   [Khalil, Radwa] Jacobs Univ, Dept Psychol & Methods, Bremen, Germany.
C3 University of Bremen; Otto von Guericke University; Otto von Guericke
   University; Leibniz Association; Leibniz Institut fur Neurobiologie
   (LIN); Otto von Guericke University; Otto von Guericke University;
   Leibniz Institut fur Pflanzenbiochemie; University of Bremen; Leibniz
   Association; Leibniz Institut fur Neurobiologie (LIN); Constructor
   University
RP Fendt, M (corresponding author), Otto von Guericke Univ, Inst Pharmacol & Toxicol, Leipziger Str 44, D-39120 Magdeburg, Germany.
EM andreas.coors@uni-bremen.de; marcel.brosch@st.ovgu.de;
   evelyn.kahl@med.ovgu.de; r.khalil@jacobs-university.de;
   bmichels@lin-magdeburg.de; annegret.laub@ipb-halle.de;
   katrin.franke@ipb-halle.de; bgerber@lin-magdeburg.de;
   markus.fendt@med.ovgu.de
RI Fendt, Markus/G-1888-2013; Khalil, Radwa/HJI-9279-2023
OI Fendt, Markus/0000-0002-3451-1226; Khalil, Radwa/0000-0003-2632-8306;
   Laub, Annegret/0000-0001-6633-3439; Franke, Katrin/0000-0003-3043-3571
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NR 68
TC 17
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U1 1
U2 33
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD MAY 10
PY 2019
VL 235
BP 320
EP 328
DI 10.1016/j.jep.2019.02.031
PG 9
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA HR4OW
UT WOS:000463126800032
PM 30776471
DA 2026-05-27
ER

PT J
AU Hou, Y
   Wang, XB
   Chen, XR
   Zhang, J
   Ai, XP
   Liang, YS
   Yu, YY
   Zhang, Y
   Meng, XL
   Kuang, TT
   Hu, Y
AF Hou, Ya
   Wang, Xiaobo
   Chen, Xiaorui
   Zhang, Jing
   Ai, Xiaopeng
   Liang, Yusheng
   Yu, Yangyang
   Zhang, Yi
   Meng, Xianli
   Kuang, Tingting
   Hu, Yao
TI Establishment and evaluation of a simulated high-altitude hypoxic brain
   injury model in SD rats
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE high-altitude hypoxia; hypobaric chamber; brain injury; Sprague-Dawley
   rats; hypoxia-inducible factor-1; mitochondrial apoptosis
ID CEREBRAL-ISCHEMIA; HYPOBARIC HYPOXIA; PATHWAY; SALIDROSIDE; HIF-1-ALPHA;
   EXPRESSION; MECHANISM; APOPTOSIS; PI3K/AKT
AB This study was conducted to establish a stable hypobaric hypoxia brain injury model. SD rats were randomly separated into control and model groups, and placed outside or inside of a hypobaric chamber, respectively. Subsequent to 24 h anoxic exposure, plasma superoxide dismutase (SOD), malondialdehyde (MDA), glutathione (GSH), oxidized glutathione (GSSG) and lactate dehydrogenase (LDH) were measured using commercial biochemical kits. Hematoxylin-eosin (H&E), Nissl's and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining were used to observe the morphology of neurons in the hippocampus. The protein expression levels of apoptotic protease activating factor-1 (Apaf-1), hypoxia inducible factor-1 (HIF-1), caspase-3, cleaved caspase-3, Bcl-2-associated X protein (Bax) and cytochrome c (cyto-c) were detected using western blot and immunohistochemistry analyses. Hypoxic substantially induced morphological lesions in the hippocampus concomitant with the physical behavioral performance deficit. Furthermore, hypoxia markedly exacerbated the levels of MDA, LDH and GSSG, and restrained GSH (P<0.01) and SOD (P<0.05) levels compared with the control group. In addition, hypoxia significantly induced the protein expression of Apaf-1, HIF-1, caspase-3, cleaved caspase-3, Bax and Cyto-c (P<0.01) compared with the control group. Finally, a lower number and volume of Nissl bodies were verified in the hypoxic group. TUNEL results demonstrated a greater number of apoptotic cells in the hypoxic group. The present study demonstrates a model of rat hypoxic brain injuries induced by a hypobaric chamber at 9,000 m for 24 h. Furthermore, the redox enzyme, HIF-1 and mitochondrial apoptosis-associated protein, along with H&E and Nissl's staining, may be applied to evaluate the degree of injury.
C1 [Hou, Ya; Wang, Xiaobo; Chen, Xiaorui; Ai, Xiaopeng; Liang, Yusheng; Meng, Xianli; Hu, Yao] Chengdu Univ Tradit Chinese Med, Dept Pharmacol Chinese Mat Med, Sch Pharm, Chengdu 611137, Sichuan, Peoples R China.
   [Zhang, Jing; Yu, Yangyang; Zhang, Yi; Kuang, Tingting] Chengdu Univ Tradit Chinese Med, Ethn Med Coll, Dept Tibetan Med, 1166 Liutai St, Chengdu 611137, Sichuan, Peoples R China.
   [Meng, Xianli] Chengdu Univ Tradit Chinese Med, Inst Tradit Chinese Med Innovat, Chengdu 611137, Sichuan, Peoples R China.
   [Hu, Yao] Chengdu Univ Tradit Chinese Med, Dept Sports Med, Inst Phys Educ, 1166 Liutai St, Chengdu 611137, Sichuan, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine; Chengdu University of Traditional
   Chinese Medicine; Chengdu University of Traditional Chinese Medicine
RP Kuang, TT (corresponding author), Chengdu Univ Tradit Chinese Med, Ethn Med Coll, Dept Tibetan Med, 1166 Liutai St, Chengdu 611137, Sichuan, Peoples R China.; Hu, Y (corresponding author), Chengdu Univ Tradit Chinese Med, Dept Sports Med, Inst Phys Educ, 1166 Liutai St, Chengdu 611137, Sichuan, Peoples R China.
EM 13424821@qq.com; 392402056@qq.com
FU National Natural Science Foundation of China [81403187]; State
   Administration of Traditional Chinese Medicine of the People's Republic
   of China [201507002]; Sichuan Science and Technology Program
   [19YYJC1922]
FX The present study was supported by the National Natural Science
   Foundation of China (grant no. 81203000), National Natural Science
   Foundation of China (grant no. 81403187), State Administration of
   Traditional Chinese Medicine of the People's Republic of China, Special
   Scientific Research in the Traditional Chinese Medicine field (grant no.
   201507002) and Supported by Sichuan Science and Technology Program
   (grant no. 19YYJC1922).
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NR 47
TC 40
Z9 55
U1 1
U2 38
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD APR
PY 2019
VL 19
IS 4
BP 2758
EP 2766
DI 10.3892/mmr.2019.9939
PG 9
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA HQ7YD
UT WOS:000462639100032
PM 30720143
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Farzaei, MH
   Bahramsoltani, R
   Rahimi, R
AF Farzaei, Mohammad Hosein
   Bahramsoltani, Roodabeh
   Rahimi, Roja
TI Phytochemicals as Adjunctive with Conventional Anticancer Therapies
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Neoplasia; antineoplastic; radiotherapy; chemotherapeutic;
   phytochemical; medicinal plant; cancer; natural product; herbal compound
ID PHASE-II TRIAL; CONTROLLED CLINICAL-TRIAL; T-LYMPHOCYTE SUBSETS;
   PERILLYL ALCOHOL; PROSTATE-CANCER; BETA-CAROTENE; DOUBLE-BLIND;
   CELL-LINES; LYCOPENE SUPPLEMENTATION; EUROPEAN ORGANIZATION
AB Background: Cancer is defined as the abnormal proliferations of cells which could occur in any tissue and can cause life-threatening malignancies with high financial costs for both patients and health care system. Plant-derived secondary metabolites are shown to have positive role in various diseases and conditions. The aim of the present study is to summarize clinical evidences on the benefits of phytochemicals as adjuvant therapy along with conventional anticancer therapies. Methods: Electronic databases including Pub-med, Scopus and Cochrane library were searched with the keywords "chemotherapeutic", "anticancer", "antineoplastic" or "radiotherapy" with "plant", "extract", "herb", or "phytochemical", until July 2015. Only clinical studies were included in this review. Results: The findings showed that positive effects of phytochemicals are due to their direct anticarcinogenic activity, induction of relief in cancer complications, as well as their protective role against side effects of conventional chemotherapeutic agents. Results obtained from current review demonstrated that numerous phytochemical agents from different chemical categories including alkaloid, benzopyran, coumarin, carotenoid, diarylheptanoid, flavonoid, indole, polysaccharide, protein, stilbene, terpene, and xanthonoid possess therapeutic effect in patients with different types of cancer. Polyphenols are the most studied components. Curcumin, ginsenosides, lycopene, homoharringtonine, aviscumine, and resveratrol are amongst the major components with remarkable volumes of clinical evidence indicating their direct anticancer activities in different types of cancer including hepatocarcinoma, prostate cancer, leukemia and lymphoma, breast and ovarian cancer, and gastrointestinal cancers. Cannabinoids, cumarin, curcumin, ginsenosides, epigallocatechin gallate, vitexin, and salidroside are phytochemicals with significant alleviative effect on synthetic chemotherapy-induced toxicities. Conclusion: There is lack of evidence from clinical trials in case of a large number of phytochemicals and further human studies are recommended to confirm the role of plant metabolites in the management of cancer.
C1 [Farzaei, Mohammad Hosein] Kermanshah Univ Med Sci, Pharmaceut Sci Res Ctr, Kermanshah, Iran.
   [Farzaei, Mohammad Hosein] Kermanshah Univ Med Sci, Med Biol Res Ctr, Kermanshah, Iran.
   [Bahramsoltani, Roodabeh] Univ Tehran Med Sci, Fac Pharm, Tehran, Iran.
   [Rahimi, Roja] Univ Tehran Med Sci, Sch Tradit Med, Dept Tradit Pharm, Tehran, Iran.
C3 Kermanshah University of Medical Sciences; Kermanshah University of
   Medical Sciences; Tehran University of Medical Sciences; Tehran
   University of Medical Sciences
RP Rahimi, R (corresponding author), Univ Tehran Med Sci, Sch Tradit Med, Dept Tradit Pharm, Tehran, Iran.
EM rahimi_r@tums.ac.ir
RI Farzaei, Mohammad/M-5779-2017; Rahimi, Roja/O-3230-2016; Bahramsoltani,
   Roodabeh/A-1001-2018
OI Rahimi, Roja/0000-0001-8637-4350; Bahramsoltani,
   Roodabeh/0000-0001-6942-0546
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NR 92
TC 81
Z9 95
U1 0
U2 51
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2016
VL 22
IS 27
BP 4201
EP 4218
DI 10.2174/1381612822666160601100823
PG 18
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DX9PH
UT WOS:000384727100008
PM 27262332
DA 2026-05-27
ER

PT J
AU Li, KP
   Jiang, JQ
   Shi, Z
   Zhan, LX
   Peng, LH
   Sun, WW
   Tang, YY
   Zuo, XL
   Xu, E
AF Li, Kongping
   Jiang, Jiaqi
   Shi, Zhe
   Zhan, Lixuan
   Peng, Linhui
   Sun, Weiwen
   Tang, Yanyan
   Zuo, Xialin
   Xu, En
TI Neuroprotective Effects of Rhodiola Sacra on Transient Global Cerebral
   Ischemia Through Activating AMPK/Nrf2 Pathway in Rats
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Article
DE rhodiola sacra; cerebral ischemia; neuroprotection; adenosine
   monophosphate-activated protein kinase; nuclear factor erythroid 2
   related factor 2
ID ATTENUATES BRAIN-DAMAGE; PROTEIN-KINASE; OXIDATIVE STRESS;
   UP-REGULATION; AMPK; SALIDROSIDE; NRF2; MODEL; HIPPOCAMPAL; EXPRESSION
AB Aims: Rhodiola sacra is a widely used pharmaceutical component with multiple functions, including anti-oxidation and anti-inflammation. However, the exact mechanisms involved in neuroprotection against transient global cerebral ischemia (tGCI) remain to be elucidated. Herein, we aim at closing the gap in understanding on whether rhodiola sacra reduces neuronal death in hippocampal CA1 and at demonstrating how rhodiola sacra offers neuroprotection after tGCI.Results: The results show that rhodiola sacra (2.4 g/kg/d by feeding) pretreatment or/and postreatment significantly alleviated neuronal injury, inhibited glial activation, and improved cognitive function in male rats subjected to tGCI. The neuroprotection of prophylaxis with rhodiola sacra is equivalent to that of therapeutics. The binding mode of adenosine monophosphate-activated protein kinase (AMPK) alpha 2-subunit with rhodiola sacra was predicted by molecular docking. Further, rhodiola sacra upregulates phosphorylated AMPK and promotes nuclear translocation of nuclear factor erythroid 2 related factor 2 (Nrf2). In addition, rhodiola sacra increases heme oxygenase-1 (HO-1) expression and activity and reduces malondialdehyde (MDA) content in CA1 after tGCI. However, the neuroprotection of rhodiola sacra is abolished by Nrf2 knockdown with small interfering RNA (siRNA) after tGCI. Similarly, the inhibition of AMPK with Compound C or siRNA against AMPK alpha 2 aggravates neuronal death after tGCI through decreasing nuclear Nrf2 and the expression and activity of HO-1, and by increasing the release of MDA.Innovation and Conclusion: For the first time, this study demonstrates that as a prophylactic or therapeutic agent rhodiola sacra prevents oxidant stress, protects neurons, and improves cognitive function through activating the AMPK/Nrf2 pathway in tGCI rats.
C1 [Li, Kongping; Jiang, Jiaqi; Shi, Zhe; Zhan, Lixuan; Peng, Linhui; Sun, Weiwen; Tang, Yanyan; Zuo, Xialin; Xu, En] Guangdong Prov & Minist Educ China, Key Lab Neurogenet & Channelopath, Guangzhou, Peoples R China.
   [Li, Kongping; Jiang, Jiaqi; Shi, Zhe; Zhan, Lixuan; Peng, Linhui; Sun, Weiwen; Tang, Yanyan; Zuo, Xialin; Xu, En] Guangzhou Med Univ, Affiliated Hosp 2, Inst Neurosci, Dept Neurol, 250 Changgang Dong Rd, Guangzhou 510260, Peoples R China.
   [Jiang, Jiaqi; Shi, Zhe] Guangzhou Med Univ, Affiliated Hosp 6, Peoples Hosp Qingyuan, Dept Neurol, Qingyuan, Peoples R China.
C3 Guangzhou Medical University; Guangzhou Medical University
RP Xu, E (corresponding author), Guangzhou Med Univ, Affiliated Hosp 2, Inst Neurosci, Dept Neurol, 250 Changgang Dong Rd, Guangzhou 510260, Peoples R China.
EM enxu@163.net
FU National Natural Science Foundation of China [81873745, 81971124];
   Science and Technology Program of Guangzhou, China [202002030072]
FX This work is supported by the National Natural Science Foundation of
   China (No. 81873745, 81971124), and the Science and Technology Program
   of Guangzhou, China (No.202002030072)
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TC 13
Z9 16
U1 1
U2 40
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD MAR 1
PY 2022
VL 36
IS 7-9
BP 567
EP 591
DI 10.1089/ars.2020.8224
EA JAN 2022
PG 25
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 7V5MI
UT WOS:000739218800001
PM 34714119
DA 2026-05-27
ER

PT J
AU Li, T
   He, X
   Luo, QQ
AF Li, Tao
   He, Xuan
   Luo, Qiaoqi
TI METABOLOMIC DIFFERENTIATION OF RHODIOLA CRENULATA FROM DIFFERENT
   GEOGRAPHICAL ORIGINS OF SICHUAN PROVINCE AND TIBET, CHINA
SO PAKISTAN JOURNAL OF BOTANY
LA English
DT Article
DE NMR spectroscopy; Rhodiola crenulata; Metabolic fingerprinting;
   Phenylpropanoids; Flavonoids; Terpenes; Carbohydrates; Principal
   component analysis
ID H-1-NMR SPECTROSCOPY; MULTIVARIATE-ANALYSIS; SALIDROSIDE; PLANTS
AB Rhodiola crenulata (HK.f. et Thorns.) H.Ohba is a popularly used ethnodrug from the Qinghai-Tibetan plateau of China and a range of biological activities have been attributed to it. The chemical composition of R. crenulata is highly variable and its quality is often controlled on the basis of one or two marker compounds. In order to find out a suitable method for the quality control of this material, the metabolomic comparative analysis of the methanol extract of the twelve geographical origins of R. crenulata was carried out by H-1 NMR spectroscopy and multivariate data analysis techniques. Principal component analysis (PCA) and partial least squares (PLS) methods were applied to discriminate the samples of twelve geographical origins. The chemical compositions of the cohort are diverse and mostly mapped and well classified according to geographical origins and the month of collection. A broad range of metabolites were detected by H-1 NMR spectroscopy without any chromatographic separation. The principal component analysis and partial least squares methods used to reduce the huge data set obtained from the H-1 NMR spectra of the plant extract clearly discriminated various geographical regions of R. crenulata. The major differences in various geographical regions of R. crenulata were found to be due to phenylpropanoids, flavonoids, terpenes, and carbohydrates. The approach provides useful information and gives an overview of the difference between crude drugs of R. crenulata originating from different production environments. This method will be a useful tool for quality evaluation of R. crenulata so as to ensure batch-to-batch uniformity for crude drugs, and lay the foundation for the selection of optimal samples of geographical origins and cultivation locality of R. crenulata with excellent quality and consequently curative effects according to clinic application.
C1 [Li, Tao] Sichuan Univ, West China Sch Pharm, Dept Nat Med, 17,Sect 3,Ren Min Nan Lu Rd, Chengdu 610041, Sichuan, Peoples R China.
   Minist Educ, Key Lab Drug Targeting, 17,Sect 3,Ren Min Nan Lu Rd, Chengdu 610041, Sichuan, Peoples R China.
C3 Sichuan University
RP Li, T (corresponding author), Sichuan Univ, West China Sch Pharm, Dept Nat Med, 17,Sect 3,Ren Min Nan Lu Rd, Chengdu 610041, Sichuan, Peoples R China.
EM scdxlitao@scu.edu.cn
FU Applied Basic Research Project of Sichuan Science and Technology
   Department [2016JY0247]; Technology Huimin Technology Research and
   Development Project of Chengdu Science and Technology Bureau
   [2016-HM01-00339-SF]
FX This study was supported by research grants from the Applied Basic
   Research Project of Sichuan Science and Technology Department (No.
   2016JY0247) and Technology Huimin Technology Research and Development
   Project of Chengdu Science and Technology Bureau (No.
   2016-HM01-00339-SF).
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NR 27
TC 2
Z9 4
U1 3
U2 12
PU PAKISTAN BOTANICAL SOC
PI KARACHI
PA DEPT OF BOTANY UNIV KARACHI, 32 KARACHI, PAKISTAN
SN 0556-3321
EI 2070-3368
J9 PAK J BOT
JI Pak. J. Bot.
PD DEC
PY 2017
VL 49
IS 6
BP 2285
EP 2293
PG 9
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences
GA FR6BM
UT WOS:000419150400026
DA 2026-05-27
ER

PT J
AU Zhang, Y
   Liu, QH
   Zhang, T
   Wang, H
   Fu, Y
   Wang, WT
   Li, DD
AF Zhang, Yan
   Liu, Qinghuan
   Zhang, Ting
   Wang, Hong
   Fu, Yu
   Wang, Wentong
   Li, Dongdong
TI The therapeutic role of Jingchuan tablet on ischaemic cerebral stroke
   via the HIF-1α/EPO/VEGFA signalling pathway
SO PHARMACEUTICAL BIOLOGY
LA English
DT Article
DE Cerebral ischaemia; neuronal apoptosis; network pharmacology; molecular
   mechanism; traditional Chinese medicine
ID NETWORK PHARMACOLOGY; RHODIOLA-ROSEA; ARTERY OCCLUSION; RATS;
   EXPRESSION; COMPONENTS; MECHANISM; INJURY; ALPHA; CELLS
AB Context Jingchuan tablet (JCT) is a Chinese medicine prescription for treating ischaemic cerebral stroke (ICS). However, its relevant mechanisms remain unclear. Objective To unravel the intrinsic mechanisms of JCT anti-ICS. Materials and methods 'Hongjingtian', 'chuanxiong', 'yanhusuo', 'bingpian', 'cerebral infarction', 'cerebral ischemia' or 'stroke' were used as keywords, and then components, targets and underlying mechanisms of JCT anti-ICS were analysed in TCMSP, TTD, DrugBank, STRING and Metascape databases up to June 2020. Male Sprague-Dawley rats under permanent middle cerebral artery occlusion (pMCAO) model, randomly assigned as: model, sham, nimodipine (0.012 g/kg/d) and JCT (0.78, 1.56 and 3.12 g/kg/d) groups, received oral gavage administration for a week. Therapeutic effects were evaluated by detecting the proportion of cerebral infarction, neuronal apoptosis and neurological deficits. Bioactive components were detected by HPLC-MS. Molecular biology and computational docking were used to verify the underlying mechanisms. Results Eighty-one components, 166 targets and HIF-1 alpha/EPO/VEGFA pathway contributed to the anti-ICS effect of JCT. JCT treatment effectively reduced the proportion of cerebral infarction (33.13%), apoptosis rate (14.80%) and neurobehavioural score (2.00). JCT increased the protein levels of HIF-1 alpha (0.84), EPO (0.64) and VEGFA (0.69), respectively (p < 0.05). Gallic acid, salidroside, chlorogenic acid, ethyl gallate, ferulic acid and tetrahydropalmatine detected by HPLC-MS showed good interaction and binding with HIF-1 alpha/EPO/VEGFA. Conclusions Our study demonstrated the mechanisms of JCT anti-ICS associated with the activation of the HIF-1 alpha/EPO/VEGFA pathway, which provided a pharmacological basis for expanding the clinical application and some scientific ideas for further research into the material basis JCT anti-ICS.
C1 [Zhang, Yan; Liu, Qinghuan; Zhang, Ting; Wang, Hong; Fu, Yu; Wang, Wentong; Li, Dongdong] Tianjin Inst Med & Pharmaceut Sci, 79 Duolun Rd, Tianjin 300020, Peoples R China.
RP Fu, Y; Li, DD (corresponding author), Tianjin Inst Med & Pharmaceut Sci, 79 Duolun Rd, Tianjin 300020, Peoples R China.
EM fyyyyy_82@126.com; lidongdong2010@163.com
OI li, dongdong/0000-0002-6519-7129
FU Natural Science Foundation of Tianjin [17JCYBJC28700]; Scientific
   Research Project of Traditional Chinese Medicine and Integrated
   Traditional Chinese and Western Medicine of Tianjin Municipal Health
   Commission, Tianjin Administration of Traditional Chinese Medicine
   [2019105]
FX This work was supported by grants from Natural Science Foundation of
   Tianjin (No. 17JCYBJC28700); Scientific Research Project of Traditional
   Chinese Medicine and Integrated Traditional Chinese and Western Medicine
   of Tianjin Municipal Health Commission, Tianjin Administration of
   Traditional Chinese Medicine (No. 2019105).
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NR 46
TC 8
Z9 9
U1 1
U2 24
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1388-0209
EI 1744-5116
J9 PHARM BIOL
JI Pharm. Biol.
PD DEC 31
PY 2022
VL 60
IS 1
BP 2110
EP 2123
DI 10.1080/13880209.2022.2134430
PG 14
WC Plant Sciences; Medical Laboratory Technology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Medical Laboratory Technology; Pharmacology & Pharmacy
GA 5M1NB
UT WOS:000870870100001
PM 36269045
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zheng, L
   Zhou, T
   Liu, H
   Zhou, ZY
   Chi, MY
   Li, YT
   Gong, ZP
   Huang, Y
AF Zheng, Lin
   Zhou, Ting
   Liu, Hui
   Zhou, Zuying
   Chi, Mingyan
   Li, Yueting
   Gong, Zipeng
   Huang, Yong
TI Pharmacokinetics Study of Jin-Gu-Lian Prescription and Its Core Drug
   Pair (Sargentodoxa cuneata (Oliv.) Rehd. et W and Alangium
   chinense (Lour.) Harms) by UPLC-MS/MS
SO MOLECULES
LA English
DT Article
DE Jin-Gu-Lian; core drug pair; pharmacokinetics; UPLC-MS; MS
AB Jin-Gu-Lian (JGL) is traditionally used by Miao for the treatment of rheumatism arthralgia. At the same time, the combination of Sargentodoxa cuneata (Oliv.) Rehd. et W (SC) and Alangium chinense (Lour.) Harms (AC), the core drug pair (CDP) in the formula of JGL, is used at high frequencies in many Miao medicine prescriptions for rheumatic diseases. However, previous research lacks the pharmacokinetic study of JGL, and study on the compatibility of its CDP with other medicinal herbs in the formula is needed. This study aims to establish a simple, rapid, and sensitive Ultra Performance Liquid Chromatography Tandem Mass Spectrometry (UPLC-MS/MS) method for the simultaneous determination of four main bioactive components of JGL in rat plasma, including Salidroside (Sal), Anabasine (Ana), Chlorogenic Acid (CA), and Protocatechuic Acid (PCA), and compare the pharmacokinetic properties of two groups of rats after being orally administrated with JGL and its CDP extracts, respectively. The results showed that area under the plasma concentration-time curve (AUC), mean retention time (MRT), and clearance rate (CL), of Sal, Ana, CA and PCA in the two groups of rats were changed in different degrees. The CDP combined with other drugs could significantly increase the absorption of Sal and Ana, prolong its retention time in vivo, and may accelerate the absorption rate of CA and PCA. This indicated that the combination of CDP and other herbs may affect the pharmacokinetics process of active components in vivo, increase the exposure and bioavailability of compounds in the JGL group, and prolong the retention time, which may be the reason why JGL has a better inhibitory effect on inflammatory cytokines, providing a viable orientation for the compatibility investigation of herb medicines.
C1 [Zheng, Lin; Zhou, Ting; Liu, Hui; Zhou, Zuying; Li, Yueting; Gong, Zipeng; Huang, Yong] Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guizhou Prov Key Lab Pharmaceut, Guiyang 550004, Peoples R China.
   [Zhou, Ting; Liu, Hui; Zhou, Zuying; Chi, Mingyan] Guizhou Med Univ, Sch Pharm, Guiyang 550004, Peoples R China.
   [Chi, Mingyan] Guizhou Med Univ, Engn Res Ctr Dev & Applicat Ethn Med & TCM, Minist Educ, Guiyang 550004, Peoples R China.
C3 Guizhou Medical University; Guizhou Medical University; Guizhou Medical
   University
RP Gong, ZP; Huang, Y (corresponding author), Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guizhou Prov Key Lab Pharmaceut, Guiyang 550004, Peoples R China.
EM zheng12020@126.com; z_tillie@163.com; liuhui554321@126.com;
   zu_ing@163.com; naoko_568@sina.com; nhwslyt@163.com; gzp4012607@126.com;
   huangy2020@126.com
RI ; Gong, Zipeng/AAD-2686-2019
OI Huang, Yong/0000-0002-4519-1192; Zhou, Zuying/0000-0003-4879-7621
FU National Natural Science Foundation of China [81960763]; National Key
   R&D Program of China [2018YFC1708100]; Guizhou Science and Technology
   Department [[2022]031-1]
FX This work was supported by the National Natural Science Foundation of
   China (grant numbers 81960763); the National Key R&D Program of China
   (grant numbers 2018YFC1708100); and Guizhou Science and Technology
   Department (grant numbers GCC[2022]031-1).
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NR 27
TC 2
Z9 3
U1 0
U2 31
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD JUL
PY 2022
VL 27
IS 13
AR 4025
DI 10.3390/molecules27134025
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 2Y1OY
UT WOS:000825662800001
PM 35807271
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Wang, XB
   Hou, Y
   Li, QY
   Li, XH
   Wang, WX
   Ai, XP
   Kuang, TT
   Chen, XR
   Zhang, Y
   Zhang, J
   Hu, Y
   Meng, XL
AF Wang, Xiaobo
   Hou, Ya
   Li, Qiuyue
   Li, Xuanhao
   Wang, Wenxiang
   Ai, Xiaopeng
   Kuang, Tingting
   Chen, Xiaorui
   Zhang, Yi
   Zhang, Jing
   Hu, Yao
   Meng, Xianli
TI Rhodiola crenulata attenuates apoptosis and mitochondrial energy
   metabolism disorder in rats with hypobaric hypoxia-induced brain injury
   by regulating the HIF-1α/microRNA 210/ISCU1/2(COX10) signaling pathway
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Rhodiola crenulata; Hypobaric hypoxic brain injury; HIF-1
   alpha-miR-210-ISCU1/2 (COX10); Mitochondrial metabolism; Apoptosis
ID ALTITUDE CEREBRAL EDEMA; NORMOBARIC HYPOXIA; SALIDROSIDE; PROTECTS;
   PLASMA; MIR-210; STRESS; CORTEX; LUNG
AB Ethnopharmacological relevance: Rhodiola crenulata, a traditional Tibetan medicine, has shown promise in the treatment of hypobaric hypoxia (HH)-induced brain injury. However, the underlying mechanisms remain unclear. This study investigated the protective effects of R. crenulata aqueous extract (RCAE) on HH-induced brain injury in rats.
   Materials and methods: An animal model of high-altitude hypoxic brain injury was established in SD rats using an animal decompression chamber for 24 h. Serum and hippocampus levels of superoxide dismutase (SOD), malondialdehyde (MDA), glutathione (GSH), oxidized glutathione (GSSG), and lactate dehydrogenase (LDH) were then determined using commercial biochemical kits. Neuron morphology and vitality were also evaluated using H&E and Nissl staining, and TUNEL staining was used to examine apoptosis. Gene and protein expression of HIF-1 alpha, microRNA 210, ISCU1/2, COX10, Apaf-1, cleaved Caspase-3, Caspase-3, Bax, Bcl-2, and Cyto-c were determined by western blot, immunohistochemical and qRT-PCR analysis.
   Results: RCAE administration attenuated HH-induced brain injury as evidenced by decreased levels of MDA, LDH, and GSSG, increased GSH and SOD, improvements in hippocampus histopathological changes, increased cell vitality and ATP level, and reduced apoptotic cell numbers. RCAE treatment also enhanced HIF-1 alpha, ISCU1/2, COX10, and Bcl-2 protein expression, while dramatically inhibiting expression of Apaf-1, Bax, Cyto-c, and cleaved Caspase-3. Treatment also increased gene levels of HIF-1 alpha, microRNA 210, ISCU1/2, and COX10, and decreased Caspase-3 gene production. Conclusions: RCAE attenuated HH-induced brain injury by regulating apoptosis and mitochondrial energy metabolism via the HIF-1 alpha/microRNA 210/ISCU1/2 (COX10) signaling pathway.
C1 [Wang, Xiaobo; Hou, Ya; Li, Xuanhao; Wang, Wenxiang; Ai, Xiaopeng; Chen, Xiaorui; Hu, Yao; Meng, Xianli] Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu, Sichuan, Peoples R China.
   [Wang, Xiaobo; Hou, Ya; Hu, Yao] Chengdu Univ Tradit Chinese Med, Interdisciplinary Lab Exercise & Med, Chengdu, Sichuan, Peoples R China.
   [Li, Qiuyue; Li, Xuanhao; Kuang, Tingting; Zhang, Yi; Zhang, Jing] Chengdu Univ Tradit Chinese Med, Ethn Med Coll, Chengdu, Sichuan, Peoples R China.
   [Meng, Xianli] Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Chengdu, Sichuan, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine; Chengdu University of Traditional
   Chinese Medicine; Chengdu University of Traditional Chinese Medicine
RP Hu, Y (corresponding author), Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu, Sichuan, Peoples R China.; Zhang, J (corresponding author), Chengdu Univ Tradit Chinese Med, Ethn Med Coll, Chengdu, Sichuan, Peoples R China.; Meng, XL (corresponding author), Chengdu Univ Tradit Chinese Med, Inst Tradit Chinese Med Innovat, Chengdu, Sichuan, Peoples R China.
EM 31649123@qq.com; 392402056@qq.com; xlm999@cdutcm.edu.cn
RI Wang, Wenxiang/JAO-4417-2023
OI Wang, Wenxiang/0000-0001-8797-1413
FU National Key R&D Program of China [2017YFC1703904]; Science & Technology
   Department of Sichuan Province [2018JY0467]; Sichuan Science and
   Technology Program [2019YJ0480]
FX This work was supported by the National Key R&D Program of China
   (2017YFC1703904), Science & Technology Department of Sichuan Province
   (2018JY0467) and Sichuan Science and Technology Program (2019YJ0480).
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NR 51
TC 82
Z9 105
U1 8
U2 87
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
EI 1872-7573
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD SEP 15
PY 2019
VL 241
AR 111801
DI 10.1016/j.jep.2019.03.028
PG 11
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA IP9MS
UT WOS:000480374900036
PM 30878546
DA 2026-05-27
ER

PT J
AU Tao, WW
   Dong, Y
   Su, Q
   Wang, HG
   Chen, YY
   Xue, WD
   Chen, C
   Xia, BM
   Duan, JN
   Chen, G
AF Tao, Weiwei
   Dong, Yu
   Su, Qiang
   Wang, Hanging
   Chen, Yanyan
   Xue, Wenda
   Chen, Chang
   Xia, Baomei
   Duan, Jinao
   Chen, Gang
TI Liquiritigenin reverses depression-like behavior in unpredictable
   chronic mild stress-induced mice by regulating PI3K/Akt/mTOR mediated
   BDNF/TrkB pathway
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Liquiritigenin; Depression; BDNF/TrkB; PI3 K/Akt/mTOR
ID ACUTE LUNG INJURY; MOUSE MODEL; NEUROTROPHIC FACTOR; MEMORY DEFICITS;
   IN-VIVO; SALIDROSIDE; CYTOKINES; PROTEIN; INFLAMMATION; RECEPTOR
AB Major depression is a common long-lasting or recurrent psychiatric disease with high lifetime prevalence and high incidence of suicide. The main purpose of the current study was to verify whether liquiritigenin conferred an antidepressant-like effect on the depressive mouse model established by unpredictable chronic mild stress (UCMS) and explore its possible mechanism. The results of depression related behaviors including sucrose preference test (SPT), open field test (OFT), forced swimming test (FST) and tail suspension test (TST) indicated that both liquiritigenin (7.5 mg/kg, 15 mg/kg) and fluoxetine (20 mg/kg) dramatically improved the depression symptoms. Enzyme-linked immunosorbent assay (ELISA) revealed that treatment with liquiritigenin significantly reduced the concentrations of pro inflammatory cytokines including interleukin (IL)-6, IL-1 beta and tumor necrosis factor (TNF)-alpha in serum and hippocampus. Compared with the UCMS group, the administrations of liquiritigenin, increased levels of superoxide dismutase (SOD), glutathione (GSH), catalase (CAT), and decreased Malondialdehyde (MDA) content. Meanwhile, glucocorticoids (GC) content was reduced in the liquiritigenin group, which suggested that liquiritigenin exhibiting the ameliorative effect on activated hypothalamic-pituitary-adrenal (HPA) axis stimulated with UCMS. Mice treated with liquiritigenin showed restored levels of neurotransmitter norepinephrine (NE) and serotonin (5-HT). Western blot analysis displayed up-regulated expressions of p-phosphatidylinositol 3-kinase (PI3 K), p-Akt, p-mammalian target of rapamycin (mTOR), p-tropomyosin-related kinase B (TrkB), brain-derived neurotrophic factor (BDNF). Thus, it was supposed that liquiritigenin might be useful for the treatment of chronic depression possibly through PI3 K/Akt/mTOR mediated BDNF/TrkB pathway. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Tao, Weiwei; Dong, Yu; Su, Qiang; Chen, Yanyan; Xue, Wenda; Chen, Chang; Xia, Baomei; Chen, Gang] Nanjing Univ Chinese Med, Sch Basic Biomed Sci, Ctr Translat Syst Biol & Neurosci, Nanjing 210023, Jiangsu, Peoples R China.
   [Tao, Weiwei; Duan, Jinao] Nanjing Univ Chinese Med, Jiangsu Collaborat Innovat Ctr Chinese Med Resour, Nanjing 210023, Jiangsu, Peoples R China.
   [Tao, Weiwei; Duan, Jinao] Nanjing Univ Chinese Med, Natl & Local Collaborat Engn Ctr Chinese Med Reso, Nanjing 210023, Jiangsu, Peoples R China.
   [Wang, Hanging] Ningxia Med Univ, Coll Pharm, Ningxia 750004, Peoples R China.
C3 Nanjing University of Chinese Medicine; Nanjing University of Chinese
   Medicine; Nanjing University of Chinese Medicine; Ningxia Medical
   University
RP Tao, WW; Chen, G (corresponding author), Nanjing Univ Chinese Med, Sch Basic Biomed Sci, Ctr Translat Syst Biol & Neurosci, Nanjing 210023, Jiangsu, Peoples R China.
EM taoweiweinanjing@126.com; chengang@njucm.edu.cn
RI baomei, Xia/JSL-5441-2023; Xue, Wenda/AAR-9273-2020
OI Chen, Gang/0000-0002-3507-1218
FU Foundation for Science of Chinese Medicine; Foundation for Science of
   Integrated Chinese and Western Medicine; National Natural Science
   Foundation of China [81403041]; Natural Science Foundation of Jiangsu
   Province [BK20140961, BK20140962]; Priority Academic Program Development
   of Jiangsu Higher Education Institutions (PAPD)
FX The study was supported by the Foundation for Science of Chinese
   Medicine, the Foundation for Science of Integrated Chinese and Western
   Medicine, the National Natural Science Foundation of China (81403041),
   the Natural Science Foundation of Jiangsu Province (BK20140961,
   BK20140962), and the Priority Academic Program Development of Jiangsu
   Higher Education Institutions (PAPD).
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NR 47
TC 111
Z9 144
U1 1
U2 74
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-4328
EI 1872-7549
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD JUL 15
PY 2016
VL 308
BP 177
EP 186
DI 10.1016/j.bbr.2016.04.039
PG 10
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology
GA DO5OT
UT WOS:000377833200019
PM 27113683
DA 2026-05-27
ER

PT J
AU Chen, HI
   Ou, HC
   Chen, CY
   Yu, SH
   Cheng, SM
   Wu, XB
   Lee, SD
AF Chen, Hsiu-, I
   Ou, Hsiu-Chung
   Chen, Chung-Yu
   Yu, Shao-Hong
   Cheng, Shiu-Min
   Wu, Xu-Bo
   Lee, Shin-Da
TI Neuroprotective Effect of Rhodiola crenulata in
   D-Galactose-Induced Aging Model
SO AMERICAN JOURNAL OF CHINESE MEDICINE
LA English
DT Article
DE Rhodiola crenulata; Neuroprotection; Apoptotic Pathways;
   Neurodegenerative Disorders; Aging
ID BCL-2 FAMILY PROTEINS; COGNITIVE IMPAIRMENT; RAT MODEL; ATTENUATES
   NEUROTOXICITY; ENDONUCLEASE-G; CELL-DEATH; APOPTOSIS; SALIDROSIDE; MICE;
   PATHWAY
AB The medicinal plant Rhodiola crenulata grows at high altitudes in the Arctic and mountainous regions and is commonly used in phytotherapy in Eastern European and Asian countries. In the present study, we investigated the anti-apoptotic effect of Rhodiola crenulata and its neuroprotective mechanism of action in a rat model of D-galactose-induced aging. Two groups of twelve-week-old male Wistar rats received a daily injection of D-galactose (150 mg/kg/day, i.p.) and orally administered Rhodiola crenulata (0, 248 mg/kg/day) for eight weeks, while a control group received a saline injection (1 ml/kg/day, i.p.). We examined apoptosis in the cortex and hippocampus of three groups of rats based on a terminal deoxynucleotide transferase-mediated deoxy uridine triphosphate nick-end labeling (TUNEL) positive assay. The expression levels of apoptotic and anti-apoptotic proteins in excised brains were analyzed by Western blotting. Our findings indicated that D-galactose caused marked neuronal apoptosis via activation of both extrinsic-dependent and mitochondrial-dependent apoptotic pathways. When compared to the control group, the protein levels of Fas receptor, Fas ligand, Fas-associated death domain (FADD), and activated caspase-8 (Fas-dependent apoptotic pathways), as well as those of t-Bid, Bax, cytochrome c, activated caspase-9, and activated caspase-3 (mitochondrial-dependent apoptotic pathways), were significantly increased in the D-galactose treated group. In addition, D-galactose impaired the phosphorylation of PI3K/Akt, an important survival signaling event in neurons. Rhodiola crenulata, however, protected against all these neurotoxicities in aging brains. The present study suggests that neuronal survival promoted by Rhodiola crenulata may be a potentially effective method to enhance the resistance of neurons to age-related disorders.
C1 [Chen, Hsiu-, I] Hungkuang Univ, Dept Phys Therapy, Taichung, Taiwan.
   [Ou, Hsiu-Chung; Lee, Shin-Da] Asia Univ, Dept Phys Therapy, Taichung, Taiwan.
   [Cheng, Shiu-Min] Asia Univ, Dept Healthcare Adm, Taichung, Taiwan.
   [Chen, Chung-Yu] Univ Taipei, Dept Sports Sci, Taipei, Taiwan.
   [Yu, Shao-Hong; Lee, Shin-Da] Shandong Univ Tradit Chinese Med, Coll Rehabil, Shanghai, Shandong, Peoples R China.
   [Wu, Xu-Bo; Lee, Shin-Da] Shanghai Univ Tradit Chinese Med, Peoples Hosp 7, Dept Rehabil, Shanghai, Peoples R China.
   [Wu, Xu-Bo; Lee, Shin-Da] Shanghai Univ Tradit Chinese Med, Sch Rehabil Sci, Shanghai, Peoples R China.
   [Lee, Shin-Da] China Med Univ, Grad Inst Rehabil Sci, Dept Phys Therapy, 91 Hsueh Shih Rd, Taichung 40202, Taiwan.
C3 Hungkuang University; Asia University Taiwan; Asia University Taiwan;
   University of Taipei; Shandong University of Traditional Chinese
   Medicine; Shanghai University of Traditional Chinese Medicine; Shanghai
   University of Traditional Chinese Medicine; China Medical University
   Taiwan
RP Wu, XB; Lee, SD (corresponding author), Shanghai Univ Tradit Chinese Med, Sch Rehabil Sci, Shanghai, Peoples R China.; Lee, SD (corresponding author), China Med Univ, Grad Inst Rehabil Sci, Dept Phys Therapy, 91 Hsueh Shih Rd, Taichung 40202, Taiwan.
EM wuxubo320@163.com; shinda@mail.cmu.edu.tw
RI ; Lee, Shin-Da/Q-2798-2015; Ou, Hsiu-Chung/AAQ-2489-2020
OI Cheng, Shiu-Min/0000-0001-8510-077X; Lee, Shin-Da/0000-0002-8393-8349;
   Ou, Hsiu-Chung/0000-0001-6794-3431
FU Ministry of Science and Technology [MOST 107-2314-B-468-002-MY3];
   Program for Professor of Special Appointment (Eastern Scholar, Honorary
   Chair Professor) at the Shanghai Institute of Higher Education
   [2012-47]; Outstanding Clinical Discipline Project of Shanghai Pudong
   [PWYgy2018-05]
FX We would like to thank Michael Burton of Asia University for
   proofreading the manuscript. This study was supported in part by the
   Ministry of Science and Technology (MOST 107-2314-B-468-002-MY3) and The
   Program for Professor of Special Appointment (Eastern Scholar, Honorary
   Chair Professor) at the Shanghai Institute of Higher Education (No
   2012-47). The study is supported by the Outstanding Clinical Discipline
   Project of Shanghai Pudong (PWYgy2018-05).
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NR 43
TC 13
Z9 16
U1 2
U2 35
PU WORLD SCIENTIFIC PUBL CO PTE LTD
PI SINGAPORE
PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE
SN 0192-415X
EI 1793-6853
J9 AM J CHINESE MED
JI Am. J. Chin. Med.
PY 2020
VL 48
IS 2
BP 373
EP 390
DI 10.1142/S0192415X20500196
PG 18
WC Integrative & Complementary Medicine; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; General & Internal Medicine
GA LL4UY
UT WOS:000531553500007
PM 32138536
DA 2026-05-27
ER

PT J
AU Taskova, RM
   Gotfredsen, CH
   Jensen, SR
AF Taskova, RM
   Gotfredsen, CH
   Jensen, SR
TI Chemotaxonomy of Veroniceae and its allies in the Plantaginaceae
SO PHYTOCHEMISTRY
LA English
DT Article
DE chemotaxonomy; Plantaginaceae; Veroniceae; mannitol; iridoid glucosides;
   6-O-rhamnopyranosylcatalpol esters; besperuloside; baldaccioside; CPGs;
   hebeoside
ID ACYLATED IRIDOID GLYCOSIDES; PHENYLETHANOID GLYCOSIDES; PHENYLPROPANOID
   GLYCOSIDE; PHENOLIC GLYCOSIDES; POLLEN MORPHOLOGY; GLUCOSIDES; ESTERS;
   SCROPHULARIACEAE; GLOBULARIACEAE; SPECTROSCOPY
AB In a chemosystematic investigation of tribe Veroniceae (Plantaginaceae), representatives of Camptoloma, Sibthorpia, Veronica subg. Pentascpalae and subg. Hebe, Veronicastrum, Wulfnia, and the related Ellisiophyllum and Globularia were examined for non-flavonoid glycosides. From the 14 species studied, 28 different iridoid glucosides and 10 caffeoyl phenylethanoid glucosides (CPGs), as well as salidroside and arbutin were isolated and characterized by NMR; of these, five compounds were previously unknown. It was found that the representatives of Veroniceae, as well as Globularia, were characterized by mannitol, aucubin, catalpol and catalpol esters. Each of the three studied species of Veronica subg. Hebe contained at least one of the 6-O-catalpol esters typical for Veronica s. str. (verminoside), supporting the inclusion of Hebe in Veronica. However, their main constituents were esters of 6-O-rhamnopyranosylcatalpol; a CPG, hebeoside (2'-beta-xylopyranosyl-verbascoside) was isolated from V. (Hebe) salicifolia. The two species of Veronicastrum also contained 6-O-rhamnopyranosylcatalpol esters, including the previously unknown 2",3" and 3",4"-dicinnamoyl derivatives and, in contrast to the earlier reports, they lacked 6-O-catalpol esters. The main iridoid constituents in the three investigated species of Wulfenia were 10-O-aucubin and 10-O-catalpol esters (isoscrophularioside or globularin) while baldaccioside (10-O-cinnamoyl asystasioside E) was isolated from W. baldaccii. Globularia vulgaris contained 10-O-catalpol esters (e.g., globularin) and, in addition, asperuloside together with its benzoyl analogue named besperuloside. The representatives of Sibthorpia and Ellisiophyllum were almost completely devoid of iridoids; this, however, together with the CPGs present implied a close relationship between the two genera. Camptoloma lyperiiflorum lacked hexitols but contained esters of 6-O-rhamnopyranosylcatalpol different from those found in Veroniceae but known from Buddleja, Scrophularia and Verbascum (Scrophulariaceae s. str.). (c) 2005 Elsevier Ltd. All rights reserved.
C1 Tech Univ Denmark, Dept Chem, DK-2800 Lyngby, Denmark.
   Bulgarian Acad Sci, Inst Bot, BU-1113 Sofia, Bulgaria.
C3 Technical University of Denmark; Bulgarian Academy of Sciences
RP Jensen, SR (corresponding author), Tech Univ Denmark, Dept Chem, Bldg 201, DK-2800 Lyngby, Denmark.
EM srj@kemi.dtu.dk
RI ; Gotfredsen, Charlotte Held/ABC-8211-2021
OI Jensen, Soren/0000-0003-4573-9282; Gotfredsen, Charlotte
   Held/0000-0002-7386-119X
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NR 100
TC 79
Z9 87
U1 5
U2 38
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9422
EI 1873-3700
J9 PHYTOCHEMISTRY
JI Phytochemistry
PD FEB
PY 2006
VL 67
IS 3
BP 286
EP 301
DI 10.1016/j.phytochem.2005.11.011
PG 16
WC Biochemistry & Molecular Biology; Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Biochemistry & Molecular Biology; Plant Sciences
GA 012AP
UT WOS:000235310900008
PM 16386770
DA 2026-05-27
ER

PT J
AU Ma, LJ
   Hou, XD
   Qin, XY
   He, RJ
   Yu, HN
   Hu, Q
   Guan, XQ
   Jia, SN
   Hou, J
   Lei, T
   Ge, GB
AF Ma, Li-Juan
   Hou, Xu-Dong
   Qin, Xiao-Ya
   He, Rong-Jing
   Yu, Hao-Nan
   Hu, Qing
   Guan, Xiao-Qing
   Jia, Shou-Ning
   Hou, Jie
   Lei, Tao
   Ge, Guang-Bo
TI Discovery of human pancreatic lipase inhibitors from root of
   Rhodiola crenulata via integrating bioactivity-guided
   fractionation, chemical profiling and biochemical assay
SO JOURNAL OF PHARMACEUTICAL ANALYSIS
LA English
DT Article
DE Human pancreatic lipase; Rhodiola crenulata;
   1,2,3,4,6-Penta-O-Galloyl-beta-D-glucopyranose; Catechin gallate;
   Inhibitory mechanism
ID ALPHA-GLUCOSIDASE; OBESITY; EXTRACT; DIET; POLYSACCHARIDE; LICOCHALCONE;
   SALIDROSIDE; METABOLISM; DOCKING; AMYLASE
AB Although herbal medicines (HMs) are widely used in the prevention and treatment of obesity and obesity-associated disorders, the key constituents exhibiting anti-obesity activity and their molecular mechanisms are poorly understood. Recently, we assessed the inhibitory potentials of several HMs against human pancreatic lipase (hPL, a key therapeutic target for human obesity), among which the root-extract of Rhodiola crenulata (ERC) showed the most potent anti-hPL activity. In this study, we adopted an integrated strategy, involving bioactivity-guided fractionation techniques, chemical profiling, and biochemical assays, to identify the key anti-hPL constituents in ERC. Nine ERC fractions (retention time 1/4 12.5-35 min), obtained using reverse-phase liquid chromatography, showed strong anti-hPL activity, while the major constituents in these bioactive fractions were subsequently identified using liquid chromatography-quadrupole time-of -flight mass spectrometry (LC-Q-TOF-MS/MS). Among the identified ERC constituents, 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose (PGG) and catechin gallate (CG) showed the most potent anti-hPL activity, with pIC(50) values of 7.59 +/- 0.03 and 7.68 +/- 0.23, respectively. Further investigations revealed that PGG and CG potently inhibited hPL in a non-competitive manner, with inhibition constant (K-i) values of 0.012 and 0.082 mu M, respectively. Collectively, our integrative analyses enabled us to efficiently identify and characterize the key anti-obesity constituents in ERC, as well as to elucidate their anti-hPL mechanisms. These findings provide convincing evidence in support of the anti-obesity and lipid-lowering properties of ERC. (C) 2022 The Authors. Published by Elsevier B.V. on behalf of Xi'an Jiaotong University.
C1 [Ma, Li-Juan; Hou, Xu-Dong; Qin, Xiao-Ya; He, Rong-Jing; Yu, Hao-Nan; Hu, Qing; Guan, Xiao-Qing; Ge, Guang-Bo] Shanghai Univ Tradit Chinese Med, Inst Interdisciplinary Integrat Med Res, Shanghai Frontiers Sci Ctr TCM Chem Biol, Shanghai 201203, Peoples R China.
   [Ma, Li-Juan; Hou, Xu-Dong; Lei, Tao] Shanghai Univ Tradit Chinese Med, Putuo Hosp, Dept Endocrinol, Shanghai 200062, Peoples R China.
   [Hou, Xu-Dong; Hou, Jie] Dalian Med Univ, Coll Basic Med Sci, Dalian 116044, Peoples R China.
   [Jia, Shou-Ning] Qinghai Hosp Tradit Chinese Med, Xining 810099, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Shanghai University
   of Traditional Chinese Medicine; Dalian Medical University
RP Ge, GB (corresponding author), Shanghai Univ Tradit Chinese Med, Inst Interdisciplinary Integrat Med Res, Shanghai Frontiers Sci Ctr TCM Chem Biol, Shanghai 201203, Peoples R China.; Lei, T (corresponding author), Shanghai Univ Tradit Chinese Med, Putuo Hosp, Dept Endocrinol, Shanghai 200062, Peoples R China.
EM leitao5899@126.com; geguangbo@dicp.ac.cn
RI Lijuan, MA/AAY-7781-2021; Xudong, Hou/KZU-6503-2024
FU National Natural Science Foundation of China [82160739, 81922070,
   81973286, 81973393]; Sailing Special Project of Shanghai Rising-Star
   Program [22YF1441500]; Program for Innovative Leading Talents of Qinghai
   Province; Innovation Team and Talents Cultivation Program of National
   Administration of Tradi-tional Chinese Medicine [ZYYCXTD-D-202004];
   Shanghai Science and Technology Innovation Action Plans [20S21901500,
   20S21900900]; Shanghai Science and Technology Committee, Project of the
   National Multidisciplinary Innovation Team of Traditional Chinese
   Medicine - National Administration of Traditional Chinese Medicine, Key
   RD and Transformation Science and Technology Cooperation Pr
   [2019-HZ-819]; Basic Public Welfare Research Program of Zhejiang
   Province [LGF22H280012]
FX This work was supported by the National Natural Science Foundation of
   China (Grant Nos.: 82160739, 81922070, 81973286, and 81973393) , Sailing
   Special Project of Shanghai Rising-Star Program (Grant No.: 22YF1441500)
   , Program for Innovative Lead-ing Talents of Qinghai Province (2018 &
   2019) , Innovation Team and Talents Cultivation Program of National
   Administration of Tradi-tional Chinese Medicine (Grant No.:
   ZYYCXTD-D-202004) , Shanghai Science and Technology Innovation Action
   Plans (Grant Nos.: 20S21901500 and 20S21900900) supported by the
   Shanghai Science and Technology Committee, Project of the National
   Multidisciplinary Innovation Team of Traditional Chinese Medicine
   supported by the National Administration of Traditional Chinese
   Medicine, Key R&D and Transformation Science and Technology Cooperation
   Project of Qinghai Province (Grant No.: 2019-HZ-819) , and Basic Public
   Welfare Research Program of Zhejiang Province (Grant No.: LGF22H280012)
   . Furthermore, we are grateful to Zhou Yang (Shanghai Standard
   Technology Co., Ltd., Shanghai, China) for the contribution in the field
   of MS/MS analysis.
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NR 54
TC 29
Z9 29
U1 5
U2 54
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2095-1779
EI 2214-0883
J9 J PHARM ANAL
JI J. Pharm. Anal.
PD AUG
PY 2022
VL 12
IS 4
BP 683
EP 691
DI 10.1016/j.jpha.2022.04.002
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 5A4YM
UT WOS:000862894700016
PM 36105167
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Liu, SH
   Hsiao, YW
   Chong, E
   Singhal, R
   Fong, MC
   Tsai, YN
   Hsu, CP
   Chen, YC
   Chen, YJ
   Chiou, CW
   Chiang, SJ
   Chang, SL
   Chen, SA
AF Liu, Shuen-Hsin
   Hsiao, Ya-Wen
   Chong, Eric
   Singhal, Rahul
   Fong, Man-Cai
   Tsai, Yung-Nan
   Hsu, Chiao-Po
   Chen, Yao-Chang
   Chen, Yi-Jen
   Chiou, Chuen-Wang
   Chiang, Shuo-Ju
   Chang, Shih-Lin
   Chen, Shih-Ann
TI Rhodiola Inhibits Atrial Arrhythmogenesis in a Heart Failure Model
SO JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
LA English
DT Article
DE atrial fibrillation; heart failure; PI3K/AKT; rhodiola
ID INDUCED APOPTOSIS; FIBRILLATION; SALIDROSIDE; PHOSPHOLAMBAN;
   TACHYCARDIA; MYOCARDIUM; ACTIVATION; FATIGUE; EXTRACT; CELLS
AB Rhodiola Inhibits Atrial Arrhythmogenesis. Introduction: Rhodiola, a popular plant in Tibet, has been proven to decrease arrhythmia. The aim of this study was to elucidate the molecular mechanism and electrophysiological properties of rhodiola in the suppression of atrial fibrillation.
   Methods: This study consisted of 3 groups as follows: Group 1: normal control rabbits (n = 5); Group 2: rabbits with heart failure (HF) created by coronary ligation and who received 2 weeks of water orally as a placebo (n = 5); and Group 3: rabbits with HF who received 2 weeks of a rhodiola 270 mg/kg/day treatment orally (n = 5). The monophasic action potential, histology, and real-time polymerase chain reaction (RT-PCR) analysis of ionic channels and PI3K/AKT/eNOS were examined.
   Results: Compared with the HF group, attenuated atrial fibrosis (35.4 +/- 17.4% vs. 16.9 +/- 8.4%, P = 0.05) and improved left ventricular (LV) ejection fraction (51.6 +/- 3.4% vs. 68.0 +/- 0.5%, P = 0.001) were observed in the rhodiola group. The rhodiola group had a shorter ERP (85.3 +/- 6.8 vs. 94.3 +/- 1.2, P = 0.002), APD90 (89.3 +/- 1.5 vs. 112.7 +/- 0.7, P < 0.001) in the left atrium (LA), and decreased AF inducibility (0.90 +/- 0.04 vs. 0.42 +/- 0.04, P < 0.001) compared with the HF group. The mRNA expressions of Kv1.4, Kv1.5, Kv4.3, KvLQT1, Cav1.2, and SERCA2a in the HF LA were up-regulated after rhodiola treatment. The rhodiola-treated HF LA demonstrated higher mRNA expression of PI3K-AKT compared with the HF group.
   Conclusions: Rhodiola reversed LA electrical remodeling, attenuated atrial fibrosis and suppressed AF in rabbits with HF. The beneficial electrophysiological effect of rhodiola may be related to upregulation of Kv1.4, Kv1.5, Kv4.3, KvLQT1, Cav1.2, SERCA2a, and activation of PI3K/AKT signaling.
C1 [Liu, Shuen-Hsin] Taipei Med Univ, Shuang Ho Hosp, Div Cardiol, Dept Med, New Taipei, Taiwan.
   [Hsiao, Ya-Wen; Chiou, Chuen-Wang; Chang, Shih-Lin; Chen, Shih-Ann] Taipei Vet Gen Hosp, Div Cardiol, Taipei, Taiwan.
   [Chong, Eric] Alexandra Hosp, Jurong Hlth, Dept Med, Div Cardiol, Singapore, Singapore.
   [Singhal, Rahul] Heart & Gen Hosp, Dept Electrophysiol & Cardiac Pacing, Jaipur, Rajasthan, India.
   [Fong, Man-Cai] Cheng Hsin Gen Hosp, Div Cardiovasc Med, Taipei, Taiwan.
   [Tsai, Yung-Nan; Hsu, Chiao-Po; Chiou, Chuen-Wang; Chang, Shih-Lin; Chen, Shih-Ann] Natl Yang Ming Univ, Dept Med, Sch Med, Taipei, Taiwan.
   [Hsu, Chiao-Po] Taipei Vet Gen Hosp, Div Cardiovasc Surg, Taipei, Taiwan.
   [Chen, Yao-Chang] Natl Def Med Ctr, Dept Biomed Engn, Taipei, Taiwan.
   [Chen, Yi-Jen] Taipei Med Univ, Grad Inst Clin Med, Coll Med, Taipei, Taiwan.
   [Chen, Yi-Jen] Taipei Med Univ, Div Cardiovasc Med, Wan Fang Hosp, Dept Internal Med, Taipei, Taiwan.
   [Chiang, Shuo-Ju] Taipei Med Univ, Sch Med, Coll Med, Div Cardiol,Dept Internal Med, Taipei, Taiwan.
C3 Taipei Medical University; Shuang Ho Hospital; Taipei Veterans General
   Hospital; Cheng Hsin General Hospital; National Yang Ming Chiao Tung
   University; Taipei Veterans General Hospital; National Defense Medical
   University; Taipei Medical University; Taipei Municipal WanFang
   Hospital; Taipei Medical University; Taipei Medical University
RP Chang, SL; Chen, SA (corresponding author), Vet Gen Hosp Taipei, Div Cardiol, 201 Sec 2,Shih Pai Rd, Taipei, Taiwan.
EM ep.slchang@msa.hinet.net; epsachen@ms41.hinet.net
RI Chang, Shih-Lin/AGT-1191-2022; Hsiao, Ya-Wen/MVY-7168-2025
OI Chang, Shih-Lin/0000-0001-7030-8471; Liu,
   Shuen-Hsin/0000-0003-3912-154X; 
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NR 28
TC 21
Z9 22
U1 0
U2 11
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1045-3873
EI 1540-8167
J9 J CARDIOVASC ELECTR
JI J. Cardiovasc. Electrophysiol.
PD SEP
PY 2016
VL 27
IS 9
BP 1093
EP 1101
DI 10.1111/jce.13026
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA DZ4OT
UT WOS:000385838800013
PM 27255210
DA 2026-05-27
ER

PT J
AU Pan, BT
   Niu, B
   He, YJ
   Zhou, CK
   Xia, CL
AF Pan, Botao
   Niu, Bo
   He, Yanjun
   Zhou, Cankun
   Xia, Chenglai
TI Integrative multilevel exploration of the mechanism by which Er-Zhi-Wan
   alleviates the Parkinson's disease (PD)-like phenotype in the
   MPTP-induced PD mouse model
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Er-Zhi-Wan (EZW); MPTP-induced Parkinson's disease; Motor dysfunction;
   LC-MS; MS; CREB signaling; Neuroprotective activity
ID TRADITIONAL CHINESE MEDICINE; ALPHA-SYNUCLEIN; INDUCED NEUROTOXICITY;
   HERBAL PREPARATION; SALIDROSIDE; LEVODOPA; TRIAL
AB The neuroprotective effects of Er-Zhi-Wan (EZW), a well-known traditional Chinese formulation, in MPTP-induced Parkinson's disease (PD) models are poorly understood and require evaluation. A model of PD induced by MPTP was used to evaluate the neuroprotective effects of EZW in mice. The underlying pharmaco-logical mechanisms of EZW for the prevention and treatment of PD were then explored using a combination of multilevel databases, network pharmacology, biological experiments, and LC-MS/MS. In vivo data showed that pretreatment with EZW can be neuroprotective against MPTP-induced motor dysfunction and can effectively rescue dopaminergic neurons from MPTP-induced degeneration in mice. Furthermore, data from combined multilevel databases and network pharmacology analysis strategies suggested that the neuroprotective activity of EZW in the treatment of PD is mediated by a complicated multicomponent, multitarget network. Genes such as Grm2, Grm5, Drd2, and Grik2 were identified as important therapeutic targets. Subsequent experimental vali-dation showed that EZW can broadly regulate the mRNA levels of these receptor genes as well as BDNF, and consequently increase the phosphorylation levels of CREB to stimulate CREB signaling. These targets and signaling systems may be responsible for the reversal of neuronal death by EZW after MPTP exposure. The LC-MS/MS results also identified a wide range of chemical components of EZW, including at least 53 precise compounds, further demonstrating the complexity of the network in which EZW exerts its neuroprotective ac-tivity. Our work provides evidence for the mechanism of EZW in MPTP-PD models and supports the neuro-protective function of EZW in neurodegenerative diseases.
C1 [Pan, Botao; Niu, Bo; Zhou, Cankun; Xia, Chenglai] Southern Med Univ, Affiliated Foshan Matern & Child Healthcare Hosp, Foshan 528000, Peoples R China.
   [Xia, Chenglai] Southern Med Univ, Sch Pharmaceut Sci, Guangzhou 515150, Peoples R China.
   [He, Yanjun] Southern Med Univ, Affiliated Foshan Matern & Child Healthcare Hosp, Emergency Dept, Foshan 528000, Peoples R China.
C3 Southern Medical University - China; Southern Medical University -
   China; Southern Medical University - China
RP Xia, CL (corresponding author), Southern Med Univ, Affiliated Foshan Matern & Child Healthcare Hosp, Foshan 528000, Peoples R China.
EM xiachenglai@smu.edu.cn
RI Xia, Chenglai/HZI-7262-2023
OI Xia, Chenglai/0000-0002-4528-7960
FU Science and Technology Bureau of Foshan [FS0AA-KJ819-4901-0082]; Basic
   and Applied Basic Research Foundation of Guangdong Province
   [2022A1515110836]
FX Funding This work was supported by grants from the Science and
   Technology Bureau of Foshan (NO. FS0AA-KJ819-4901-0082) and the Basic
   and Applied Basic Research Foundation of Guangdong Province (NO.
   2022A1515110836) .
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NR 68
TC 4
Z9 5
U1 3
U2 31
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD SEP
PY 2023
VL 165
AR 115021
DI 10.1016/j.biopha.2023.115021
EA JUN 2023
PG 17
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA N0OB5
UT WOS:001034102000001
PM 37348406
OA gold
DA 2026-05-27
ER

PT J
AU Sun, YP
   Li, NJ
AF Sun, Yaping
   Li, Nengjuan
TI Effect and mechanism of action of Rhodiola rosea L on
   diabetic peripheral neuropathy in rats based on Synapsin-I
SO TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
LA English
DT Article
DE Rhodiola rosea L; Diabetic gastroparesis; Synapsin-I; Synaptic
   plasticity; Diabetic peripheral neuropathy
ID SALIDROSIDE; PROTEINS
AB Purpose: To investigate the efficacy and underlying mechanism of action of Rhodiola rosea L. on diabetic gastroparesis (DGP) based on Synapsin-I. Methods: The extract of Rhodiola rosea L. was obtained by preparing the crude medicine of traditional Chinese medicine. The Sprague-Dawley (SD) rats were randomly allocated to three groups: normal, DGP, and DGP+Rhodiola rosea L. groups. Rats in DGP+Rhodiola rosea L. group were treated with Rhodiola rosea L. once daily for 5 weeks at a dose of 150 mg & BULL;kg-1 & BULL;day-1, while rats in DGP group received an equivalent volume of saline by oral gavage. Parameters were evaluated include body weight, fasting glucose level, gastric emptying rate and gastric acid secretion. Histopathological examination of the stomach was performed by hematoxylin-eosin (H & E) staining. Immunohistochemistry, cellular immunofluorescence, as well as western blot were employed to determine the expressions of Synapsin-I and protein gene product 9.5 (PGP9.5). Results: Compared normal group, the body weight or rats in DGP group decreased, blood glucose was elevated, gastric acid secretion level decreased, and gastric emptying rate increased (p < 0.05). Besides, they also showed signs of misalignment of gastric mucosal glands, enlarged intercellular space, and significantly reduced protein expressions of PGP9.5 and Synapsin-I. Administration of Rhodiola rosea L. extract reversed the above changes in DGP rats, and also elevated the protein expression of both PGP9.5 and synapsin-I. Conclusion: Rhodiola rosea L. extract exerts a protective effect in DGP by enhancing synaptic plasticity via upregulation of expression of synapsin-I. Thus, an experimental basis has been established for the potential clinical application of Rhodiola rosea L. extract in the management of diabetic peripheral neuropathy.
C1 [Sun, Yaping] Zhuji Peoples Hosp, Dept Endocrinol & Metab, 9 Jianmin Rd,Taozhu St, Shaoxing 311800, Zhejiang, Peoples R China.
   [Li, Nengjuan] Zhejiang Chinese Med Univ, Dept Endocrinol, Affiliated Hosp 2, 318 Chaowang Rd, Hangzhou 310005, Zhejiang, Peoples R China.
C3 Zhejiang Chinese Medical University
RP Li, NJ (corresponding author), Zhejiang Chinese Med Univ, Dept Endocrinol, Affiliated Hosp 2, 318 Chaowang Rd, Hangzhou 310005, Zhejiang, Peoples R China.
EM linengjuan2007@163.com
FU Traditional Chinese Medicine Science and Technology Planning Project of
   Zhejiang Province, China [2021ZB133, 2017ZB049]
FX This work was supported by the Traditional Chinese Medicine Science and
   Technology Planning Project of Zhejiang Province, China (nos. 2021ZB133
   and 2017ZB049) .
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NR 20
TC 3
Z9 3
U1 0
U2 10
PU PHARMACOTHERAPY GROUP
PI BENIN CITY
PA UNIV BENIN, FACULTY PHARMACY, BENIN CITY, 00000, NIGERIA
SN 1596-5996
J9 TROP J PHARM RES
JI Trop. J. Pharm. Res.
PD JUN
PY 2023
VL 22
IS 6
BP 1211
EP 1218
DI 10.4314/tjpr.v22i6.10
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA L8IJ3
UT WOS:001025640200010
DA 2026-05-27
ER

PT J
AU Chen, CY
   Qin, SR
   Song, XH
   Wen, J
   Huang, W
   Sheng, Z
   Li, XG
   Cao, Y
AF Chen, Chenyang
   Qin, Sirun
   Song, Xiaohua
   Wen, Juan
   Huang, Wei
   Sheng, Zhe
   Li, Xiaogang
   Cao, Yu
TI PI3K p85α/HIF-1α accelerates the development of pulmonary arterial
   hypertension by regulating fatty acid uptake and mitophagy
SO MOLECULAR MEDICINE
LA English
DT Article
DE Pulmonary arterial hypertension; Mitophagy; Fatty acid intake; HIF-1
   alpha; CD36
ID PROTECTS; PATHWAYS
AB BackgroundPulmonary arterial hypertension (PAH) is characterized by lipid accumulation and mitochondrial dysfunction. This study was designed to investigate the effects of hypoxia-inducible factor-1 alpha (HIF-1 alpha) on fatty acid uptake and mitophagy in PAH.MethodsPeripheral blood samples were obtained from PAH patients. Human pulmonary arterial smooth muscle cells and rat cardiac myoblasts H9c2 were subjected to hypoxia treatment. Male Sprague-Dawley rats were treated with monocrotaline (MCT). Right ventricular systolic pressure (RVSP), right ventricular hypertrophy index (RVHI), pulmonary artery remodeling, and lipid accumulation were measured. Cell proliferation and ROS accumulation were assessed. Mitochondrial damage and autophagosome formation were observed. Co-immunoprecipitation was performed to verify the interaction between HIF-1 alpha and CD36/PI3K p85 alpha.ResultsHIF-1 alpha, CD36, Parkin, and PINK1 were upregulated in PAH samples. HIF-1 alpha knockdown or PI3K p85 alpha knockdown restricted the expression of HIF-1 alpha, PI3K p85 alpha, Parkin, PINK1, and CD36, inhibited hPASMC proliferation, promoted H9c2 cell proliferation, reduced ROS accumulation, and suppressed mitophagy. CD36 knockdown showed opposite effects to HIF-1 alpha knockdown, which were reversed by palmitic acid. The HIF-1 alpha activator dimethyloxalylglycine reversed the inhibitory effect of Parkin knockdown on mitophagy. In MCT-induced rats, the HIF-1 alpha antagonist 2-methoxyestradiol (2ME) reduced RVSP, RVHI, pulmonary artery remodeling, lipid accumulation, and mitophagy. Recombinant CD36 abolished the therapeutic effect of 2ME but inhibited mitophagy. Activation of Parkin/PINK1 by salidroside (Sal) promoted mitophagy to ameliorate the pathological features of PAH-like rats, and 2ME further enhanced the therapeutic outcome of Sal.ConclusionPI3K p85 alpha/HIF-1 alpha induced CD36-mediated fatty acid uptake and Parkin/PINK1-dependent mitophagy to accelerate the progression of experimental PAH.
C1 [Chen, Chenyang; Qin, Sirun; Wen, Juan; Huang, Wei; Sheng, Zhe; Li, Xiaogang; Cao, Yu] Cent South Univ, Xiangya Hosp 3, Cardiovasc Dept, Changsha 410013, Peoples R China.
   [Song, Xiaohua] 921 Hosp Joint Logist Support Force Chinese People, Dept Pediat, Changsha 410011, Peoples R China.
C3 Central South University
RP Chen, CY (corresponding author), Cent South Univ, Xiangya Hosp 3, Cardiovasc Dept, Changsha 410013, Peoples R China.
EM songxiaohuaccy@csu.edu.cn
FU National Natural Science Foundation of China
FX The authors would like to thank the staff of Third Xiangya Hospital,
   Central South University, who provided technical support for the
   research.
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NR 59
TC 14
Z9 16
U1 2
U2 9
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1076-1551
EI 1528-3658
J9 MOL MED
JI Mol. Med.
PD NOV 11
PY 2024
VL 30
IS 1
AR 208
DI 10.1186/s10020-024-00975-9
PG 23
WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental
   Medicine
GA L7J2V
UT WOS:001352437500001
PM 39528930
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Liang, TS
   Zhou, JX
   Jing, P
   He, ZJ
   Jiao, SS
   Zhao, WJ
   Tong, Q
   Jia, GF
AF Liang, Tisong
   Zhou, Jiexin
   Jing, Pu
   He, Zhengjun
   Jiao, Shunshan
   Zhao, Wenji
   Tong, Qi
   Jia, Guofu
TI Anti-senescence effects of Rhodiola crenulate extracts on
   LO2 cells and bioactive compounds
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Rhodiola crenulata; Bioactive compounds; Antioxidant; Anti-Aging;
   Caenorhabditis elegans
ID INDUCED COGNITIVE DEFICITS; PHENOLIC-COMPOUNDS; OXIDATIVE STRESS;
   CHEMICAL-CONSTITUENTS; RAT PLASMA; LIFE-SPAN; ANTIOXIDANT; ROSEA;
   POLYSACCHARIDES; SALIDROSIDE
AB Ethnopharmacological relevance: Rhodiola crenulata (Rc) is a traditional herb, used in Tibetan medicine, has shown promise efficacy in physical performance improvement, work capacity enhancement, fatigue elimination, and altitude sickness prevention. Also, Rc exhibited therapeutic effects on aging-related diseases. However, relevant researches on Rc and their bioactive components are quite few and needs further investigation. Aim of the study: The objective of this study was to understand the relationship between phytochemical profiles and their activities of Rc extracts. Materials and methods: Rc extracts prepared by solvents with various hydrophilicity (i.e. aqueous ethanol (70%, v/v), water, and ethyl acetate), and their chemical compositions and specific compounds were analyzed by chemical analysis method and ultra-performance liquid chromatography quadruple time-of-flight mass spec-trometry (UPLC-QTOF-MS). The regulate effects of Rc extracts on senescence and antioxidant activity were evaluated using the models of LO2 cells and Caenorhabditis elegans. Results: The 70% ethanol extracts exhibited better regulating effects on senescence via the assays of senescence-associated beta-galactosidase (SA beta G) staining and lifespan, which was consistent with the higher antioxidant ac-tivities observed based on the results of antioxidant assays. A total of 14 phytochemicals have been identified in 70% ethanol extracts, whereas the other two extracts contained much fewer compounds in varieties. Phyto-chemical profile of water extract was similar to the first half (polar compounds, running time: 0-6 min) of 70% ethanol extract profile, while those of ethyl acetate extract was consistent with its second half (more nonpolar compounds, running time: 6-12 min). Conclusions: The 14 phytochemicals in Rc might exhibit additive or synergistic effects on senescence regulating and antioxidant activities, providing theoretical basis for daily administration of Rc.
C1 [Liang, Tisong; Zhou, Jiexin; Jing, Pu; Jiao, Shunshan] Shanghai Jiao Tong Univ, Shanghai Food Safety & Engn Technol Res Ctr, Bor S Luh Food Safety Res Ctr, Sch Agr & Biol,Key Lab Urban Agr,Minist Agr, Shanghai 200240, Peoples R China.
   [He, Zhengjun; Zhao, Wenji; Tong, Qi; Jia, Guofu] Sichuan Acad Grassland Sci, Chengdu 624400, Sichuan, Peoples R China.
C3 Shanghai Jiao Tong University
RP Jing, P (corresponding author), Shanghai Jiao Tong Univ, Shanghai Food Safety & Engn Technol Res Ctr, Bor S Luh Food Safety Res Ctr, Sch Agr & Biol,Key Lab Urban Agr,Minist Agr, Shanghai 200240, Peoples R China.
EM Liangtisong@sjtu.edu.cn; JieXinZhou@sjtu.edu.cn; pjing@sjtu.edu.cn;
   hezhengjun2021@126.com; sjiao@sjtu.edu.cn; zhaowenji2005@163.com;
   djyqq@126.com; guo70520@163.com
RI /D-8934-2012; /AAO-5438-2020; /L-8663-2019; Jing, Pu/AAG-7020-2021
OI Jing, Pu/0000-0001-8204-7475
FU Sichuan Science and Technology Program [2019YFSY0010]
FX The authors acknowledge the financial support from the Sichuan Science
   and Technology Program (2019YFSY0010) .
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NR 75
TC 6
Z9 6
U1 4
U2 79
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
EI 1872-7573
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD APR 24
PY 2023
VL 306
AR 116179
DI 10.1016/j.jep.2023.116179
EA JAN 2023
PG 12
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA C8FS9
UT WOS:000964218300001
PM 36690308
DA 2026-05-27
ER

PT J
AU Li, MR
   Wang, XY
   Han, LF
   Jia, L
   Liu, EW
   Li, Z
   Yu, HH
   Wang, YC
   Gao, XM
   Yang, WZ
AF Li, Mengrong
   Wang, Xiaoyan
   Han, Lifeng
   Jia, Li
   Liu, Erwei
   Li, Zheng
   Yu, Heshui
   Wang, Yucheng
   Gao, Xiumei
   Yang, Wenzhi
TI Integration of multicomponent characterization, untargeted metabolomics
   and mass spectrometry imaging to unveil the holistic chemical
   transformations and key markers associated with wine steaming of
   Ligustri Lucidi Fructus
SO JOURNAL OF CHROMATOGRAPHY A
LA English
DT Article
DE Processing; Multicomponent characterization; Chemical transformation;
   Untargeted metabolomics; Mass spectrometry imaging; Ligustri Lucidi
   Fructus
ID TRADITIONAL CHINESE MEDICINE; GEOGRAPHIC ORIGINS; PANAX-GINSENG; MS;
   STRATEGY; IDENTIFICATION; FRAGMENTATION; DISCOVERY; GINSENOSIDES;
   METABOLITES
AB Processing of traditional Chinese medicine (TCM) can enhance the efficacy and/or reduce the toxicity. Currently available approaches regarding TCM processing generally focus on a few markers, rendering a one-sided strategy that fail to unveil the involved global chemical transformation. We herein present a strategy, by integrating enhanced multicomponent characterization, untargeted metabolomics, and mass spectrometry imaging (MSI), to visualize the chemical transformation and identify the markers associated with the wine steaming of Ligustri Lucidi Fructus (LLF), as a case. An ultra-high-performance liquid chromatography/quadrupole-Orbitrap mass spectrometry-based polarity-switching (between the negative and positive modes), precursor ions list-including data-dependent acquisition approach was developed, which enabled the simultaneous targeted/untargeted characterization of 158 components from LLF via one injection analysis. Holistic, continuous, and time-dependent chemical variation trajectory, among different processing time (0-12 h) for LLF, was depicted by principle component analysis. Pattern recognition chemometrics could unveil 20 markers, among which the peak area ratios of eight components to oleuropein aglycone, used as an internal standard, were diagnostic to identify the processed (both the commercial and in-house prepared) from the raw LLF. Four markers (10-hydroxyoleoside dimethylester, 8-demethyl-7-ketoliganin, elenolic acid, and salidroside) showed an increasing trend, while another four (neonuezhenide/isomer, verbascoside/isomer, luteoline, and nuzhenal A) decreased in LLF after processing. MSI visualized the spatial distribution in the fruit and indicated consistent variation trends for four major markers deduced by the untargeted metabolomics approach. This integral strategy, in contrast to the conventional approaches, gives more convincing data supporting the processing mechanism investigations of TCM from a macroscopic perspective. (C) 2020 Elsevier B.V. All rights reserved.
C1 [Li, Mengrong; Wang, Xiaoyan; Han, Lifeng; Jia, Li; Liu, Erwei; Li, Zheng; Yu, Heshui; Wang, Yucheng; Gao, Xiumei; Yang, Wenzhi] Tianjin Univ Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, 312 Anshanxi Rd, Tianjin 300193, Peoples R China.
   [Li, Mengrong; Wang, Xiaoyan; Han, Lifeng; Jia, Li; Liu, Erwei; Wang, Yucheng; Yang, Wenzhi] Tianjin Univ Tradit Chinese Med, Tianjin Key Lab TCM Chem & Anal, 312 Anshanxi Rd, Tianjin 300193, Peoples R China.
   [Li, Zheng; Yu, Heshui] Tianjin Univ Tradit Chinese Med, Coll Pharmaceut Engn Tradit Chinese Med, Tianjin 300193, Peoples R China.
C3 Tianjin University of Traditional Chinese Medicine; Tianjin University
   of Traditional Chinese Medicine; Tianjin University of Traditional
   Chinese Medicine
RP Liu, EW; Yang, WZ (corresponding author), Tianjin Univ Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, 312 Anshanxi Rd, Tianjin 300193, Peoples R China.; Liu, EW; Yang, WZ (corresponding author), Tianjin Univ Tradit Chinese Med, Tianjin Key Lab TCM Chem & Anal, 312 Anshanxi Rd, Tianjin 300193, Peoples R China.
EM liuwei628@hotmail.com; wzyang0504@tjutcm.edu.cn
RI GAO, Xiumei/IWD-8697-2023; Li, Jia/A-9852-2011; Li,
   Mengrong/KSM-6395-2024
OI Li, Mengrong/0009-0006-6560-1642
FU National Natural Science Foundation of China [81630106, 81872996];
   National Science and Technology Major Project of China [2018ZX09201011,
   2018ZX09711001-009-010, 2018ZX09735002]
FX This work was supported by National Natural Science Foundation of China
   (Grant No. 81630106 and 81872996) and National Science and Technology
   Major Project of China (Grant No. 2018ZX09201011,
   2018ZX09711001-009-010, and 2018ZX09735002). The authors also thank Jing
   Dong from Shimadzu, for the technical assistance in MSI experiments.
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NR 40
TC 48
Z9 60
U1 3
U2 142
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0021-9673
EI 1873-3778
J9 J CHROMATOGR A
JI J. Chromatogr. A
PD AUG 2
PY 2020
VL 1624
AR 461228
DI 10.1016/j.chroma.2020.461228
PG 10
WC Biochemical Research Methods; Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA LZ3TL
UT WOS:000541150900018
PM 32540070
DA 2026-05-27
ER

PT J
AU Zhou, D
   Chen, JR
   Yang, ZQ
   Xu, L
   Huang, YF
AF Zhou, Di
   Chen, Jian-Ru
   Yang, Zi-Qi
   Xu, Ling
   Huang, Yu-Feng
TI Establishment of a multicomponent quality control method and the
   transfer characteristics of five markers from Qidongning Formula to rat
   tissues by HPLC-QQQ-MS/MS
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE Astragali Radix; antitumour; Qidongning Formula (QDN); quality control;
   tissue distribution; HPLC-QQQ-MS/MS
ID PHARMACOKINETICS; PLASMA
AB Introduction: Traditional Chinese medicine compound preparations have become an increasingly utilized strategy for tumour treatment. Qidongning Formula (QDN) is a kind of antitumour compound preparation used in hospitals, and it can inhibit the growth of lung cancer cells. However, due to the complexity of botanical drugs, the quality evaluation of QDN is inconsistent, affecting clinical efficacy and posing potential safety risks for clinical application. Additionally, tissue distribution is an integral part of the drug development process.Methods: To study the distribution characteristics of markers in compound preparations and rat tissues, a novel HPLC-QQQ-MS/MS quantitative analytical method was established to determine five markers in QDN simultaneously, and the method was verified.Results and discussion: The analytical results showed that the contents of salidroside (51.6 +/- 5.75 mu g/g), calycosin-7-O-beta-D-glucoside (94.2 +/- 15.4 mu g/g), specnuezhenide (371 +/- 72.5 mu g/g), formononetin (23.8 +/- 5.39 mu g/g), and polyphyllin I (87.7 +/- 10.6 mu g/g) were stable in different batches of QDN. After intragastric administration (13.5 g/kg) in rats for 1 h, four markers in the QDN, except polyphyllin I, were distributed in most tissues. QDN was distributed chiefly in the stomach and small intestine, followed by the liver or kidney. The study also found that specnuezhenide had the highest concentration in both QDN and rat tissues (102 +/- 22.1 mu g/g in the stomach), while formononetin had the highest transfer rate (0.351%) from QDN to rat intestines. The above research lays a quality research foundation for the antitumour application of QDN and provides a scientific reference for the quality control of Chinese medicine compound preparations.
C1 [Zhou, Di; Xu, Ling] Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western M, Dept Oncol, Shanghai, Peoples R China.
   [Chen, Jian-Ru] Shanghai Tongjitang Pharmaceut Co Ltd, Shanghai, Peoples R China.
   [Yang, Zi-Qi] Guangzhou Univ Chinese Med, Coll Chinese Med, Guangzhou, Guangdong, Peoples R China.
   [Huang, Yu-Feng] Guangzhou Univ Chinese Med, State Key Lab Tradit Chinese Med Syndrome, Affiliated Hosp 2, Guangzhou, Guangdong, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Guangzhou
   University of Chinese Medicine; Guangzhou University of Chinese Medicine
RP Xu, L (corresponding author), Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western M, Dept Oncol, Shanghai, Peoples R China.; Huang, YF (corresponding author), Guangzhou Univ Chinese Med, State Key Lab Tradit Chinese Med Syndrome, Affiliated Hosp 2, Guangzhou, Guangdong, Peoples R China.
EM xulq67@aliyun.com; fongfonghuang@hotmail.com
RI Yang, Ziqi/HLG-6355-2023
FU Shanghai University of Traditional Chinese Medicine10.13039/501100010876
FX No Statement Available
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NR 24
TC 2
Z9 2
U1 3
U2 15
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD DEC 5
PY 2023
VL 14
AR 1310266
DI 10.3389/fphar.2023.1310266
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CT3F6
UT WOS:001127444900001
PM 38116079
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Shi, CY
   Li, Q
   Zhang, XY
AF Shi, Chenyang
   Li, Qin
   Zhang, Xinyue
TI Platycodin D Protects Human Fibroblast Cells from Premature Senescence
   Induced by H2O2through Improving Mitochondrial
   Biogenesis
SO PHARMACOLOGY
LA English
DT Article
DE Platycodin D; Cellular premature senescence; Oxidative stress;
   Mitochondrial biogenesis
ID INDUCED OXIDATIVE STRESS; LIVER-INJURY; GRANDIFLORUM; LONGEVITY; ROOTS;
   SALIDROSIDE; RESISTANCE; SAPONINS; FIBROSIS; MICE
AB Background:Although Platycodin D (PLD) is the main active saponin ofPlatycodon grandiflorum(PG) and responsible for multiple therapeutic benefits, including antioxidant and antiaging, only few direct demonstrations have been reported on the role of PLD in antiaging process. The present investigation was carried out to elucidate the protection of PLD against aging in vitro and associated molecular mechanisms on H2O2-induced premature senescence model in human -fetal lung diploid fibroblasts 2BS cells.Methods:The cellular morphology, cell cycle, and senescence-associated beta-galactosidase activity assays were used for senescence-like phenotypes determination in the oxidant challenged model. The oxygen-free radicals reactive oxygen species (ROS), 4-hydroxynonenal (4-HNE), and malondialdehyde (MDA) determinations were estimated by enzyme-linked immunosorbent assay assay. The potential of the mitochondria mass and the mitochondrial membrane were used to observe the alteration of mitochondria. Western blot analysis was performed to determine the protein expression.Results:The results showed that PLD significantly reversed senescence-like phenotypes in the oxidant challenged model, as well as related molecules expression such as p53, p21, and p16. Moreover, PLD treatment significantly decreased the levels of ROS, 4-HNE, and MDA in H2O2-treated 2BS cells. The mechanisms responsible for the antioxidant and antiaging effects of PLD were investigated, we found that mitochondria under PLD conditions show increase membrane potential ratio and stimulate the proliferation of mitochondria mass. In addition, the protein expression of peroxisome proliferator activated receptor gamma coactivator 1 alpha and its downstream targets, that is, nuclear respiratory factor and mitochondrial transcription factor A were also increased in mitochondrial biogenesis.Conclusion:These results indicated that PLD prevented H2O2-induced premature senescence in vitro by improving mitochondrial biogenesis to attenuate age-dependent endogenous oxidative damage.Key Message:The study revealed the antioxidant and antiaging potential of PLD against H2O2-induced premature senescence.
C1 [Shi, Chenyang; Li, Qin; Zhang, Xinyue] Zhejiang Acad Med Sci, 182 Tianmushan Rd, Hangzhou 310013, Peoples R China.
   [Shi, Chenyang] Shanghai Jiao Tong Univ, Sch Med, Shanghai Gen Hosp, Dept Clin Pharm, Shanghai, Peoples R China.
C3 Zhejiang Academy of Medical Sciences; Shanghai Jiao Tong University
RP Zhang, XY (corresponding author), Zhejiang Acad Med Sci, 182 Tianmushan Rd, Hangzhou 310013, Peoples R China.
EM zhangxinyue6815@163.com
RI Shi, Chenyang/HOC-9675-2023
FU Medical Health Science and Technology Project of Zhejiang Provincial
   Health Commission [2017KY304]; Key Laboratory of Neuropsychiatric Drug
   Research of Zhejiang Province [2019E10021]; Zhejiang Science and
   Technology Department [2017C37162]
FX This work was supported by grants from the Medical Health Science and
   Technology Project of Zhejiang Provincial Health Commission (2017KY304),
   The Key Laboratory of Neuropsychiatric Drug Research of Zhejiang
   Province (2019E10021), and Zhejiang Science and Technology Department
   (2017C37162).
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NR 39
TC 27
Z9 34
U1 1
U2 19
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0031-7012
EI 1423-0313
J9 PHARMACOLOGY
JI Pharmacology
PD OCT
PY 2020
VL 105
IS 9-10
BP 598
EP 608
DI 10.1159/000505593
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA OC4JP
UT WOS:000579124400013
PM 32008007
DA 2026-05-27
ER

PT J
AU Li, L
   Liu, Q
   Shi, LJ
   Zhou, XB
   Wu, W
   Wang, X
   Wang, LH
   Wu, ZH
AF Li, Li
   Liu, Qian
   Shi, Lijuan
   Zhou, Xibin
   Wu, Wei
   Wang, Xue
   Wang, Lihua
   Wu, Zhihong
TI Baicalin prevents fibrosis of human trabecular meshwork cells via
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SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Glaucoma; Baicalin; Trabecular meshwork; Fibrosis; TGF-?2
ID EXTRACELLULAR-MATRIX; RECEPTOR 4; IN-VITRO; SALIDROSIDE; PRESSURE;
   OUTFLOW; INJURY
AB Trabecular meshwork fibrosis contributes to increased aqueous humor outflow resistance, leading to elevated intraocular pressure in primary open-angle glaucoma. Baicalin, an extract from Scutellaria baicalensis Georgi, has shown anti-fibrotic effects in liver, lung, and kidney diseases. However, its anti-fibrotic effect on human trabecular meshwork (HTM) cells has not yet been clarified. In this study, we investigated its effects on TGF-beta 2-induced HTM fibrosis as well as the underlying regulatory mechanisms. HTM cells were pretreated with baicalin, TAK-242, and baicalin + TAK-242 for 2 h followed by treatment with or without 5 ng/mL TGF-beta 2 for 48 h. Cell viability was assayed using cell counting Kit-8 and fibronectin (FN), laminin (LN), and alpha-smooth muscle actin (alpha-SMA) were assessed by western blotting, reverse transcription-polymerase chain reaction (RT-PCR), and immunocytochemistry. Further, the protein and gene expression levels of the TLR4/MyD88/NF-kappa B pathway (TLR4, MyD88, and NF-kappa B p65) were also examined by western blotting and RT-PCR, respectively. Thus, we observed that high doses of baicalin (40 mu M) decreased (p < 0.1) HTM cell viability and 20 mu M baicalin pre-treatment was identified as the optimum pretreatment concentration. TGF-beta 2 upregulated (p < 0.5) the expression of FN, LN, alpha-SMA, MyD88, NF-kappa B p65 proteins and mRNA in HTM cells, and these effects were inhibited by baicalin and TAK-242 (p < 0.5). However, western blot analysis showed that baicalin did not repress TLR4 expression in HTM cells. Therefore, our findings suggested that baicalin could prevent TGF-beta 2-induced extracellular matrix (FN, LN) deposition and alpha-SMA expression in HTM cells by inhibiting the MyD88/NF-kappa B pathway.
C1 [Li, Li; Shi, Lijuan] Weifang Med Univ, Weifang 261053, Peoples R China.
   [Li, Li; Shi, Lijuan; Zhou, Xibin; Wu, Wei; Wang, Xue; Wang, Lihua; Wu, Zhihong] Peoples Liberat Army Gen Hosp, Med Ctr 3, Dept Ophthalmol, Beijing 100039, Peoples R China.
   [Li, Li; Liu, Qian] Beijing Ophthalmol & Visual Sci Key Lab, Beijing 100005, Peoples R China.
   [Liu, Qian] Capital Med Univ, Beijing Tongren Hosp, Beijing Tongren Eye Ctr, Beijing Inst Ophthalmol, Beijing 100005, Peoples R China.
C3 Shandong Second Medical University; Chinese People's Liberation Army
   General Hospital; Capital Medical University
RP Wu, ZH (corresponding author), Peoples Liberat Army Gen Hosp, Med Ctr 3, Dept Ophthalmol, Beijing 100039, Peoples R China.
EM fswuzhihong@sina.com
RI Wu, ZHIHONG/GQI-1730-2022; LIJUAN, SHI/ODL-9904-2025
FU Beihang University-Capital Medical University Advanced Innovation Center
   for Big Data-Based Precision Medicine, Tongren Subcenter Open Fund
   Project [BHTRKFJJ-202017]
FX This work was supported by the Beihang University-Capital Medical
   University Advanced Innovation Center for Big Data-Based Precision
   Medicine, Tongren Subcenter Open Fund Project (grant number
   BHTRKFJJ-202017).
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NR 44
TC 12
Z9 14
U1 0
U2 17
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD JAN 5
PY 2023
VL 938
AR 175425
DI 10.1016/j.ejphar.2022.175425
EA NOV 2022
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 6X4EV
UT WOS:000896369100002
PM 36442621
DA 2026-05-27
ER

PT J
AU Wang, TW
   Wang, YL
   Liu, XT
   Gao, XN
   Hu, K
AF Wang, Tianwei
   Wang, Yali
   Liu, Xueting
   Gao, Xiaoning
   Hu, Kun
TI Combined Transcriptomics and Metabolomics Analyses in Grass Carp Under
   Anesthetic Stress
SO FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
LA English
DT Article
DE anesthetics; ecotoxicology; transcriptome; metabolome; arachidonic acid
ID SERUM CORTISOL-LEVELS; CLOVE OIL; TRICAINE METHANESULFONATE; CHANNEL
   CATFISH; 2-PHENOXYETHANOL; EFFICACY; STURGEON; MS-222; FISH
AB Ctenopharyngodon Idella, as a common freshwater bony fish, is more susceptible to various diseases than other carp species, so it has been proposed as a test organism for toxicological analysis In this study, C. idella were anesthetized with MS-222 and 2-PE, and the related anesthetic mechanism and toxic effects were revealed by transcriptomics and metabolomics analyses. When the concentration of MS-222 was 80 mg/L and 200 mg/L, 179 and 887 differentially expressed genes (DEGs), respectively, were identified in the brain tissue of C. idella. When the concentration of 2-PE was 0.6 mL/L and 1.2 mL/L, 498 and 514 DEGs were identified. The DEGs associated with MS-222 treatment were enriched in immune pathways, lipid metabolism, amino acid metabolism, and various signaling pathways; DEGs associated with 2-PE treatment were enriched in immunity and amino acid metabolism. In total, 304 metabolites were identified using a combination of positive and negative ion modes in mass spectrometry. The common differential metabolites identified in the MS-222 high and low concentration groups were 20-HETE and 12(R)-HETE; the common significant differential metabolite identified in the 2-PE high and low concentration groups was salidroside. In combination with the transcriptomics analysis and metabolomics analysis, the results showed that with the MS-222 and 2-PE concentrations used in this experiment, the metabolism of arachidonic acid in C. idella was inhibited by MS-222, and 2-PE affected the upstream and downstream metabolic pathways of arachidonic acid metabolism, thereby affecting the metabolism of arachidonic acid. Both anesthetics induce sedation by affecting related metabolites that affect stress response and autoimmunity. Metabolomics results showed that neither anesthetic had a significant effect on cortisol expression.
C1 [Wang, Tianwei; Wang, Yali; Liu, Xueting; Gao, Xiaoning; Hu, Kun] Shanghai Ocean Univ, Natl Pathogen Collect Ctr Aquat Anim, Shanghai Engn Res Ctr Aquaculture, Natl Demonstrat Ctr Expt Fisheries Sci Educ, Shanghai, Peoples R China.
   [Wang, Tianwei; Wang, Yali; Liu, Xueting; Gao, Xiaoning; Hu, Kun] Minist Rural Agr, Natl Fisheries Tech Extens Ctr, Beijing, Peoples R China.
   [Wang, Tianwei; Wang, Yali; Liu, Xueting; Gao, Xiaoning; Hu, Kun] Chinese Acad FisherySciences, East China Sea Fisheries Res Inst, Key Lab East China Sea Fishery Resources Exploitat, Minist Agr, Shanghai, Peoples R China.
C3 Shanghai Ocean University; Chinese Academy of Fishery Sciences; East
   China Sea Fisheries Research Institute, CAFS
RP Hu, K (corresponding author), Shanghai Ocean Univ, Natl Pathogen Collect Ctr Aquat Anim, Shanghai Engn Res Ctr Aquaculture, Natl Demonstrat Ctr Expt Fisheries Sci Educ, Shanghai, Peoples R China.; Hu, K (corresponding author), Minist Rural Agr, Natl Fisheries Tech Extens Ctr, Beijing, Peoples R China.; Hu, K (corresponding author), Chinese Acad FisherySciences, East China Sea Fisheries Res Inst, Key Lab East China Sea Fishery Resources Exploitat, Minist Agr, Shanghai, Peoples R China.
EM khu@shou.edu.cn
FU National Key R&D Program of China [2019YFD0900102]; Science and
   Technology Commission of Shanghai Municipality [18391901500];
   NationalNatural Resources Platform and Shanghai Ocean University
   KnowledgeService Platform, China
FX This study was supported by the National Key R & D Program of
   China(2019YFD0900102), China, the Science and Technology Commission of
   Shanghai Municipality [grant number 18391901500], and the
   NationalNatural Resources Platform and Shanghai Ocean University
   KnowledgeService Platform, China. Other authors provided material
   support for this paper and assisted in data analysis.
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NR 44
TC 9
Z9 11
U1 7
U2 76
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2235-2988
J9 FRONT CELL INFECT MI
JI Front. Cell. Infect. Microbiol.
PD JUL 11
PY 2022
VL 12
AR 931696
DI 10.3389/fcimb.2022.931696
PG 12
WC Immunology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Microbiology
GA 3I4QM
UT WOS:000832703500001
PM 35899048
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Huang, JJ
   Xie, Y
   Li, H
   Zhang, XX
   Huang, Q
   Zhu, Y
   Gu, P
   Jiang, WM
AF Huang Jing-Jing
   Xie Yong
   Li He
   Zhang Xiao-Xiao
   Huang Qing
   Zhu Yao
   Gu Ping
   Jiang Wei-Min
TI YQWY decoction reverses cardiac hypertrophy induced by TAC through
   inhibiting GATA4 phosphorylation and MAPKs
SO CHINESE JOURNAL OF NATURAL MEDICINES
LA English
DT Article
DE YQWY decoction; Cardiac hypertrophy; GATA4 phosphorylation; MAPKs
ID TRANSCRIPTION FACTORS GATA4; 2013 ACCF/AHA GUIDELINE; ASSOCIATION
   TASK-FORCE; HEART-FAILURE; AMERICAN-COLLEGE; IN-VITRO; GENE;
   SALIDROSIDE; EXPRESSION; MANAGEMENT
AB To investigate the effect of Yiqi Wenyang (YQWY) decoction on reversing cardiac hypertrophy induced by the transverse aortic constriction (TAC). Wistar rats aged 7-8 weeks were subjected to TAC surgery and then randomly divided into 4 groups (n = 5/group): Sham group, TAC group, low-dose group and high dose group. After 16-week intragastric administration of YQWY decoction, the effect of YQWY decoction on alleviating cardiomyocyte hypertrophy was examined by transthoracic echocardiography (TTE), hematoxylin/eosin (HE), wheat germ agglutinin (WGA) staining, enzyme linked immunosorbent assay (ELISA), Western blot (WB), immunohistochemistry (IHC) and immunofluorescence (IF), respectively. The results showed significant differences in left ventricle volume-diastole/systole (LV Vol d/s), N-terminal pro-B-type brain natriuretic peptide (NT-proBNP) (P < 0.01), Ejection Fraction (EF), LV mass and fractional shortening (FS) (P < 0.05) between YQWY-treated group and TAC group. HE and WGA staining showed that treatment with YQWY decoction dramatically prevented TAC-induced cardiomycyte hypertrophy. Moreover, the results of WB, IHC and IF indicated that administration of YQWY could suppress the expressions of cardiac hypertrophic markers, which included the atrial natriuretic peptide (ANP), BNP and myosin heavy chain 7 (MYH7) (P < 0.05) and inhibit phosphorylation of GATA binding protein 4 (P-GATA4) (P < 0.05), phosphorylation of extracellular signal-regulated kinase (P-ERK) (P < 0.05), phosphorylation of P38 mitogen activated protein kinase (P-P38) (P < 0.05) and phosphorylation of c-Jun N-terminal kinase (P-JNK) (P < 0.05). Thus, we concluded that YQWY decoction suppressed cardiomyocyte hypertrophy and reversed the impaired heart function, and the curative effects of YQWY decoction were associated with the decreased phosphorylation of GATA4 and mitogen activated protein kinases (MAPKs), as well as the reduced expression of the downstream targets of GATA4, including ANP, BNP, and MYH7.
C1 [Huang Jing-Jing; Xie Yong; Li He; Zhang Xiao-Xiao; Huang Qing; Zhu Yao; Jiang Wei-Min] Nanjing Univ Chinese Med, Jiangsu Prov Hosp Tradit Chinese Med, Affiliated Hosp, Nanjing 210029, Jiangsu, Peoples R China.
   [Gu Ping] Nanjing Univ, Jinling Hosp, Sch Med, Dept Endocrinol, Nanjing 21002, Jiangsu, Peoples R China.
C3 Nanjing University of Chinese Medicine; Nanjing University
RP Jiang, WM (corresponding author), Nanjing Univ Chinese Med, Jiangsu Prov Hosp Tradit Chinese Med, Affiliated Hosp, Nanjing 210029, Jiangsu, Peoples R China.; Gu, P (corresponding author), Nanjing Univ, Jinling Hosp, Sch Med, Dept Endocrinol, Nanjing 21002, Jiangsu, Peoples R China.
EM ping-19762000@163.com; jwm0410@njucm.edu.cn
FU National Natural Science Foundation of China [81774134, 81373605];
   Natural Science Foundation of Jiangsu Province, China [BK20171331,
   BK20181503]; Scientific Research Foundation of the State Human Resource
   Ministry for Returned Chinese Scholars, China; 333 High Level Talents
   Training Project of Jiangsu Province, China [BRA2017595]; Postgraduate
   Scientific Research Innovation Program of Jiangsu Province, China
   [KYCX18_1547, KYCX19_1188]
FX This work was supported by the National Natural Science Foundation of
   China (Nos. 81774134 and 81373605), the Natural Science Foundation of
   Jiangsu Province, China (Nos. BK20171331 and BK20181503), the Scientific
   Research Foundation of the State Human Resource Ministry for Returned
   Chinese Scholars, China and 333 High Level Talents Training Project of
   Jiangsu Province, China (No. BRA2017595) and the Postgraduate Scientific
   Research Innovation Program of Jiangsu Province, China (No.
   KYCX18_1547&KYCX19_1188).
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NR 37
TC 10
Z9 11
U1 1
U2 9
PU CHINESE JOURNAL NATURAL MEDICINES
PI NANJING
PA 24, TONGJIA XIANG, NANJING, 210009, PEOPLES R CHINA
SN 2095-6975
EI 1875-5364
J9 CHIN J NAT MEDICINES
JI Chin. J. Nat. Med.
PD OCT
PY 2019
VL 17
IS 10
BP 746
EP 755
PG 10
WC Integrative & Complementary Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; Pharmacology & Pharmacy
GA JK7JV
UT WOS:000495018100004
PM 31703755
DA 2026-05-27
ER

PT J
AU Guiré, R
   Salo, P
   Zongo, E
   Ramadan, MF
   Koama, BK
   Meda, RNT
   Al-Asmari, F
   Rahim, MA
AF Guire, Rasmane
   Salo, Pousbila
   Zongo, Eliasse
   Ramadan, Mohamed Fawzy
   Koama, Benjamin Kouliga
   Meda, Roland Nag-Tiero
   Al-Asmari, Fahad
   Rahim, Muhammad Abdul
TI The inhibitory activities of two compounds from Securidaca
   longepedunculata Fresen on the acetylcholinesterase from wheat pest
   Schizaphis graminum Rondani: in silico analysis
SO PLANT SIGNALING & BEHAVIOR
LA English
DT Article
DE Acetylcholinesterase; <italic>S. longepedunculata</italic>; <italic>S.
   graminum</italic>; molecular docking; molecular dynamic simulation
ID CHIH-DFT; PROTEIN; DESIGN
AB Wheat is the third most widely consumed cereal in the world, after maize and rice. However, it is regularly attacked by the wheat aphid (Schizaphis graminum), causing considerable damage to wheat crops. The acetylcholinesterase enzyme, which plays a key role in the transmission of the synaptic cholinergic signal, has emerged as a promising target for the development of pest control strategies. Inhibition of this enzyme leads to the paralysis or even death of the aphid. The objective of this study is to identify the bioactive compounds in Securidaca longepedunculata (S. longepedunculata) that are capable of interacting with acetylcholinesterase from Schizaphis graminum and inhibiting its activity. Furthermore, a computer simulation of these compounds in interaction with the key protein was conducted. First, the secondary metabolites of S. longepedunculata were selected on the basis of GC-MS data available from specific reference sources. Subsequently, the compounds were subjected to virtual screening based on their docking scores in order to identify those with inhibitory properties. The compounds with the highest scores were subjected to molecular dynamics simulation over a 50 ns trajectory. Subsequently, MMGBSA free energy calculations were conducted. The results demonstrated that eight compounds exhibited inhibitory properties, four of which (echimidine, populin, salidroside, and farrerol) demonstrated superior stabilizing effects on proteins compared to the remaining compounds. In terms of free energy by MMGBSA and molecular simulation, it was observed that echimidine and populin formed robust and stable hydrogen bonds with the amino acids of the acetylcholinesterase enzyme. This study identifies and attempts to validate the potential inhibitory activities of echimidine and populin against acetylcholinesterase, with a view to developing potent insecticides and unique treatment strategies.
C1 [Guire, Rasmane; Salo, Pousbila; Zongo, Eliasse; Koama, Benjamin Kouliga; Meda, Roland Nag-Tiero] Univ Nazi BONI, Lab Res & Teaching Anim Hlth & Biotechnol, Bobo Dioulasso, Burkina Faso.
   [Ramadan, Mohamed Fawzy] Umm Al Qura Univ, Fac Appl Med Sci, Dept Clin Nutr, Mecca, Saudi Arabia.
   [Al-Asmari, Fahad] King Faisal Univ, Coll Agr & Food Sci, Dept Food & Nutr Sci, Al Hasa, Saudi Arabia.
   [Rahim, Muhammad Abdul] Times Inst, Fac Med & Allied Hlth Sci, Dept Food Sci & Nutr, Multan, Pakistan.
C3 Umm Al-Qura University; King Faisal University
RP Guiré, R; Zongo, E (corresponding author), Univ Nazi BONI, Lab Res & Teaching Anim Hlth & Biotechnol, Bobo Dioulasso, Burkina Faso.; Rahim, MA (corresponding author), Times Inst, Fac Med & Allied Hlth Sci, Dept Food Sci & Nutr, Multan, Pakistan.
EM rasmaneguire.yt@gmail.com; zongoeliasse@yahoo.fr; mabdulrahim@t.edu.pk
RI , Fahad Al-Asmari/AAO-8017-2020; Ramadan, Mohamed/A-3294-2008; Eliasse,
   ZONGO/HKO-9466-2023; Rahim, Muhammad Abdul/JVD-7113-2023; Meda, Roland
   NT/IYS-2991-2023
OI , Fahad Al-Asmari/0000-0003-4253-2796; 
FU Deanship of Scientific Research, Vice Presidency for Graduate Studies
   and Scientific Research, King Faisal University, Saudi Arabia
   [KFU242708]
FX This work was supported by the Deanship of Scientific Research, Vice
   Presidency for Graduate Studies and Scientific Research, King Faisal
   University, Saudi Arabia [Project No. KFU242708].
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NR 44
TC 1
Z9 1
U1 6
U2 24
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1559-2316
EI 1559-2324
J9 PLANT SIGNAL BEHAV
JI Plant Signal. Behav.
PD DEC 31
PY 2025
VL 20
IS 1
AR 2444311
DI 10.1080/15592324.2024.2444311
PG 9
WC Biochemistry & Molecular Biology; Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Plant Sciences
GA P8F2M
UT WOS:001380193300001
PM 39701807
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Lai, MC
   Lin, JG
   Pai, PY
   Lai, MH
   Lin, YM
   Yeh, YL
   Cheng, SM
   Liu, YF
   Huang, CY
   Lee, SD
AF Lai, Mei-Chih
   Lin, Jaung-Geng
   Pai, Pei-Ying
   Lai, Mei-Hsin
   Lin, Yueh-Min
   Yeh, Yu-Lan
   Cheng, Shiu-Min
   Liu, Yi-fan
   Huang, Chih-Yang
   Lee, Shin-Da
TI Effects of rhodiola crenulata on mice hearts under severe sleep apnea
SO BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
DE Apoptosis; Caspase; Cardiac; Hypoxia; Rhodiola; Survival; VEGF
ID DEPENDENT APOPTOTIC PATHWAY; SALIDROSIDE PROTECTS; HYPOBARIC HYPOXIA;
   CARDIAC FIBROSIS; DOUBLE-BLIND; H9C2 CELLS; SHORT-TERM; FAMILY; RAT;
   MITOCHONDRIA
AB Background: The goal of this study is to determine if Rhodiola Crenulata (RC) has protective effects on mice hearts with severe sleep apnea model.
   Methods: Sixty-four C57BL/6 J mice 5-6 months old were distributed into 4 groups i.e. Control group (21 % O-2, 24 h per day, 8 weeks, n = 16); Hypoxia group (Hypoxia: 7 % O-2 60 s, 20 % O-2 alternating 60 s, 8 h per day, 8 weeks, n = 16); Hypoxia + 90RC and Hypoxia + 270RC group (Hypoxia for 1st 4 weeks and hypoxia pretreated 90 mg/Kg and 270 mg/Kg Rhodiola Crenulata by oral gavage per day for 2nd 4 weeks, each n = 16). Excised hearts from 4 groups of mice were analyzed for heart weight index changes using H&E staining, TUNEL-positive assays and Western Blotting protein.
   Results: Cardiac widely dispersed TUNEL-positive apoptotic cells in mice hearts were less in Hypoxia + RC90 and Hypoxia + RC270 than those in Hypoxia. Compared with Hypoxia, the protein levels of Fas ligand, Fas death receptors, Fas-Associated Death Domain (FADD), activated caspase 8, and activated caspase 3 (Fas dependent apoptotic pathways) were decreased in Hypoxia + RC90, Hypoxia + RC270. The protein levels of Bad, Bax, t-Bid, activated caspase 9, activated caspase 3 (mitochondria dependent apoptotic pathway) were less in Hypoxia + RC90, Hypoxia + RC270 than those in hypoxia. The protein levels of Bcl2, Bcl-xL, p-Bad (Bcl2-realted anti-apoptotic pathway) and VEGF, p-PI3k, p-AKT (VEGF-related pro-survival pathway) were higher in Hypoxia + RC90, Hypoxia + RC270 than those in hypoxia.
   Conclusions: Our findings suggest that Rhodiola Crenulata have protective effects on chronic intermittent hypoxia-induced cardiac widely dispersed apoptosis via Fas-dependent and mitochondria-dependent apoptotic and VEGF-related pro-survival pathway.
C1 [Lai, Mei-Chih; Lin, Jaung-Geng; Huang, Chih-Yang] China Med Univ, Grad Inst Chinese Med, Taichung, Taiwan.
   [Pai, Pei-Ying; Lee, Shin-Da] China Med Univ & Hosp, Grad Inst Clin Med Sci, Taichung, Taiwan.
   [Lai, Mei-Hsin] Hungkuang Univ, Dept Nursing, Master Program, Taichung, Taiwan.
   [Lin, Yueh-Min; Yeh, Yu-Lan] Changhua Christian Hosp, Dept Pathol, Changhua, Taiwan.
   [Lin, Yueh-Min; Yeh, Yu-Lan] Jen Jr Coll Med Nursing & Management, Dept Med Technol, Miaoli, Taiwan.
   [Cheng, Shiu-Min] Asia Univ, Dept Psychol, Taichung, Taiwan.
   [Liu, Yi-fan; Lee, Shin-Da] China Med Univ, Dept Phys Therapy, Taichung, Taiwan.
   [Liu, Yi-fan; Lee, Shin-Da] China Med Univ, Grad Inst Rehabil Sci, Taichung, Taiwan.
   [Huang, Chih-Yang] China Med Univ & Hosp, Grad Inst Basic Med Sci, Taichung, Taiwan.
   [Huang, Chih-Yang] Asia Univ, Dept Hlth & Nutr Biotechnol, Taichung, Taiwan.
   [Lee, Shin-Da] Asia Univ, Dept Healthcare Adm, Taichung, Taiwan.
C3 China Medical University Taiwan; China Medical University Taiwan; China
   Medical University Hospital - Taiwan; Hungkuang University; Changhua
   Christian Hospital; Asia University Taiwan; China Medical University
   Taiwan; China Medical University Taiwan; China Medical University
   Taiwan; China Medical University Hospital - Taiwan; Asia University
   Taiwan; Asia University Taiwan
RP Lee, SD (corresponding author), China Med Univ & Hosp, Grad Inst Clin Med Sci, Taichung, Taiwan.
EM shinda@mail.cmu.edu.tw
RI ; Lee, Shin-Da/Q-2798-2015; Huang, Chih-Yang/Q-4862-2016
OI Cheng, Shiu-Min/0000-0001-8510-077X; Lee, Shin-Da/0000-0002-8393-8349;
   Huang, Chih-Yang/0000-0003-2347-0411
FU National Science Council [NSC 98-2622-B-039-004-CC3]; Asia University
   [CMU98-asia-08]; China Medical University, Taiwan [CMU99-COL-21]; Taiwan
   Ministry of Health and Welfare Clinical Trial and Research Center of
   Excellence [MOHW104-TDU-B-212-113002]
FX The study is supported by the National Science Council (NSC
   98-2622-B-039-004-CC3), Asia University (CMU98-asia-08) and China
   Medical University (CMU99-COL-21), Taiwan. This study supported in part
   by Taiwan Ministry of Health and Welfare Clinical Trial and Research
   Center of Excellence (MOHW104-TDU-B-212-113002). We'd like to thank TCM
   Biotech International Corp., Taiwan for providing Rhodiola Crenulata in
   this study.
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NR 40
TC 10
Z9 11
U1 3
U2 15
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1472-6882
J9 BMC COMPLEM ALTERN M
JI BMC Complement. Altern. Med.
PD JUN 25
PY 2015
VL 15
AR 198
DI 10.1186/s12906-015-0698-0
PG 12
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA CL2KT
UT WOS:000356773300001
PM 26108210
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Liu, T
   Xia, QM
   Lv, YS
   Wang, ZJ
   Zhu, S
   Qin, WX
   Yang, Y
   Wang, X
   Zhao, ZY
   Ma, HF
   Jia, LL
   Zhang, H
   Xu, ZP
   Li, N
AF Liu, Tao
   Xia, QingMei
   Lv, Yingshuang
   Wang, Zijing
   Zhu, Shan
   Qin, Wenxiao
   Yang, Yi
   Wang, Xiang
   Zhao, Zhiyue
   Ma, Hongfei
   Jia, Linlin
   Zhang, Han
   Xu, Zongpei
   Li, Nan
TI ErZhiFormula prevents UV-induced skin photoaging by Nrf2/HO-1/NQO1
   signaling: An in vitro and in vivo studies
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE EZF; UV; ROS; Nrf2; HO-1; NQO1; Skin photoaging
ID INDUCED OXIDATIVE STRESS; ER-ZHI-WAN; ULTRAVIOLET-RADIATION; PATHWAY;
   INFLAMMATION; APOPTOSIS; UPDATE; TARGET; CELLS; ROS
AB Ethnopharmacological relevance: ErZhiFormula (EZF) is a classical traditional Chinese medicinal formulation. It can be used to treat liver and kidney yin deficiency, dizziness, lumbar debility, insomnia, nocturnal emission, lower extremity weakness, and other aging-related diseases. However, the protective effect of EZF in skin photoaging and its potential mechanism has not been clarified.Aim of the study: This study aims to explore the role of EZF in the skin photoaging mechanism induced by UV radiation.Materials and methods: Ultra Performance Liquid Chromatography (UPLC) was used to identify the fingerprint of EZF. The mice were irradiated with UVA and UVB to establish the photoaging model in vivo. Human immor-talized keratinocytes (HaCaT) were irradiated with UVB to establish the photoaging model in vitro. The activity of cells was detected by CCK-8 and LDH kits, the level of reactive oxygen species was detected by DCF fluorescent probe, and the apoptosis was detected by PE annexin V and 7-Amino-Actinomycin (7-AAD) staining. Comet assay was used to detect cell DNA damage. The antioxidant enzyme levels in cell and mouse serum were detected by antioxidant kit, and Western blot was used to detect protein expression.Results: We found that EZF contain many active ingredients, including salidroside, specnuezhenide, isoquercitrin, etc. EZF can improve the photoaging of HaCaT cells and mouse skin caused by UV radiation. The results of animal experiments are consistent with those of cell experiments. Combined with Western blot analysis, we found that EZF finally played an anti-skin photoaging role by regulating the Nrf2/HO-1/NQO1 pathway.Conclusions: EZF can protect skin from UV-induced photoaging by regulating the Nrf2/HO-1/NQO1 signal pathway. EZF may become a traditional Chinese medicine with the potential to prevent skin photoaging.
C1 [Liu, Tao; Xia, QingMei; Wang, Zijing; Xu, Zongpei] Tianjin Univ Tradit Chinese Med, Sch Tradit Chinese Med, Tianjin 301617, Peoples R China.
   [Liu, Tao; Lv, Yingshuang; Wang, Zijing; Zhu, Shan; Qin, Wenxiao; Yang, Yi; Wang, Xiang; Zhao, Zhiyue; Ma, Hongfei; Jia, Linlin; Zhang, Han; Li, Nan] Tianjin Univ Tradit Chinese Med, Inst Tradit Chinese Med, Tianjin 301617, Peoples R China.
C3 Tianjin University of Traditional Chinese Medicine; Tianjin University
   of Traditional Chinese Medicine
RP Xu, ZP (corresponding author), Tianjin Univ Tradit Chinese Med, Sch Tradit Chinese Med, Tianjin 301617, Peoples R China.; Li, N (corresponding author), Tianjin Univ Tradit Chinese Med, Inst Tradit Chinese Med, Tianjin 301617, Peoples R China.
EM 13802080971@163.com; linan@tjutcm.edu.cn
RI Lu, Yingshuang/ABE-4977-2021; jia, linlin/NIU-8117-2025
FU National Natural Science Foundation of China [82274618, 81803862]
FX The National Natural Science Foundation of China (No. 82274618,
   81803862) supported this study.
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NR 90
TC 23
Z9 27
U1 3
U2 76
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
EI 1872-7573
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD JUN 12
PY 2023
VL 309
AR 115935
DI 10.1016/j.jep.2022.115935
EA MAR 2023
PG 13
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA A0CW9
UT WOS:000951902500001
PM 36414213
DA 2026-05-27
ER

PT J
AU Jasemi, SV
   Khazaei, H
   Momtaz, S
   Farzaei, MH
   Echeverría, J
AF Jasemi, Sayed Vahid
   Khazaei, Hosna
   Momtaz, Saeideh
   Farzaei, Mohammad Hosein
   Echeverria, Javier
TI Natural products in the treatment of pulmonary emphysema: Therapeutic
   effects and mechanisms of action
SO PHYTOMEDICINE
LA English
DT Review
DE Chronic obstructive pulmonary disease; Lung diseases; Pulmonary
   emphysema; Medicinal plants; Natural compounds; Phytochemicals
ID OXIDATIVE STRESS; IN-VIVO; PUNICA-GRANATUM; AIRWAY INFLAMMATION;
   DIALLYL-DISULFIDE; PROTECT MICE; TOXICITY; RESVERATROL; SALIDROSIDE;
   DISEASE
AB Background: Chronic obstructive pulmonary disease (COPD) is a class of lung diseases including chronic bronchitis, asthma, and emphysema. Long-time smoking is considered the main reason for developing emphysema. Emphysema can be defined as damage to the walls of the air sacs (alveoli) of the lung. It has been demonstrated that natural compounds with antioxidant and anti-inflammatory effects can effectively improve or protect the lung against this disease. This paper is dedicated to systematically review the effective natural compounds in the treatment of pulmonary emphysema.Purpose: This is the first systematic and comprehensive review on the role of plant-derived secondary metabolites in managing and/or treating pulmonary emphysemaStudy design and Methods: A systematic and comprehensive review was done based on Scopus, PubMed, and Cochrane Library databases were searched using the "emphysema", "plant", "herb", and "phytochemical" keywords. Non-English, review, and repetitive articles were excluded from the study. Search results were included in the Prisma diagram.Results: From a total of 1285 results, finally, 22 articles were included in the present study. The results show that some herbs such as Scutellaria baicalensis Georgi and Monascus adlay and some phytochemicals such as gallic acid and quercetin and blackboard tree indole alkaloids affect more factors in improving the lung emphysema. Also, some natural compounds such as marijuana smoke and humic acid also play an aggravating role in this disease. It also seems that some of the medicinal plants such as PM014 herbal formula, pomegranate juice and acai berry sometimes have side effects that are inconsistent with their therapeutic effects. Conclusion: We concluded that natural compounds can effectively improve pulmonary emphysema due to their antioxidant, anti-inflammatory, and anti-apoptotic properties. However, additional studies are suggested to prove efficacy and side effects.
C1 [Jasemi, Sayed Vahid] Kermanshah Univ Med Sci, Fac Med, Dept Internal Med, Kermanshah, Iran.
   [Khazaei, Hosna; Farzaei, Mohammad Hosein] Kermanshah Univ Med Sci, Pharmaceut Sci Res Ctr, Hlth Inst, Kermanshah, Iran.
   [Momtaz, Saeideh] Univ Tehran Med Sci, Med Plants Res Ctr, Pharmaceut Sci Res Ctr PSRC, Tehran, Iran.
   [Momtaz, Saeideh] Univ Tehran Med Sci, Inst Pharmaceut Sci TIPS, Pharmaceut Sci Res Ctr PSRC, Dept Toxicol & Pharmacol,Sch Pharm, Tehran, Iran.
   [Momtaz, Saeideh] Univ Tehran Med Sci, Pharmaceut Sci Res Ctr PSRC, Inst Pharmaceut Sci TIPS, Toxicol & Dis Grp, Tehran, Iran.
   [Momtaz, Saeideh] Universal Sci Educ & Res Network USERN, GI Pharmacol Interest Grp GPIG, Tehran, Iran.
   [Echeverria, Javier] Univ Santiago Chile, Fac Quim & Biol, Dept Ciencias Ambiente, Santiago, Chile.
C3 Kermanshah University of Medical Sciences; Kermanshah University of
   Medical Sciences; Tehran University of Medical Sciences; Tehran
   University of Medical Sciences; Tehran University of Medical Sciences;
   Universal Scientific Education & Research Network (USERN); Universidad
   de Santiago de Chile
RP Farzaei, MH (corresponding author), Kermanshah Univ Med Sci, Pharmaceut Sci Res Ctr, Hlth Inst, Kermanshah, Iran.; Echeverría, J (corresponding author), Univ Santiago Chile, Fac Quim & Biol, Dept Ciencias Ambiente, Santiago, Chile.
EM mh.farzaei@gmail.com
RI Farzaei, Mohammad/M-5779-2017; Echeverría, Javier/AAK-3323-2020
OI Echeverría, Javier/0000-0002-1688-968X
FU CONICYT PAI/ACADEMIA [79160109]
FX Acknowledgments This work was supported by DICYT-USACH 022041_EM
   Postdoctoral and CONICYT PAI/ACADEMIA No. 79160109.
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NR 120
TC 18
Z9 20
U1 3
U2 23
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD MAY
PY 2022
VL 99
AR 153988
DI 10.1016/j.phymed.2022.153988
EA FEB 2022
PG 12
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA 1B0YR
UT WOS:000792171100002
PM 35217434
DA 2026-05-27
ER

PT J
AU Han, JH
   Dai, M
   Zhao, Y
   Cai, EB
   Zhang, LX
   Jia, XH
   Sun, N
   Fei, X
   Shu, H
AF Han, Jiahong
   Dai, Min
   Zhao, Yan
   Cai, Enbo
   Zhang, Lianxue
   Jia, Xiaohuan
   Sun, Nian
   Fei, Xuan
   Shu, Hui
TI Compatibility effects of ginseng and Ligustrum lucidum Ait herb
   pair on hematopoietic recovery in mice with cyclophosphamide-induced
   Ched myelosuppression and its material basis
SO JOURNAL OF GINSENG RESEARCH
LA English
DT Article
DE Chemotherapy; Ginseng; Ginseng-Ligustrum lucidum Ait herb pair; Material
   basis; Myelosuppression
ID PANAX-GINSENG; HUMAN HEALTH; APOPTOSIS; MODEL; POLYSACCHARIDES;
   CHEMOTHERAPY
AB Background: Ginseng (G) and Ligustrum lucidum Ait (LLA) are core traditional Chinese medicines in treating myelosuppression formula. The present study was designed to profile effect of G and LLA herb pair (G-LLA) on myelosuppressed mice.
   Methods: The mice myelosuppression model was established by intraperitoneal (i.p.) injection of cyclophosphamide (Cy). Hematopoietic function of bone marrow was measured by hemopoietic progenitor cell culture and peripheral blood count, and serum hemopoietic factors were tested by enzymelinked immunosorbent assay. Bone marrow cell cycle was performed by flow cytometry. HPLC was used to measure 20 potential chemical components related to myelosuppression, including ginsenoside Re, Rb-1, Rc, Rb-2, Rb-3, Rd, Rk(3), Rh-4, 20 (S)-Rg(3), 20 (R)-Rg(3), Rk(1), Rg(5), salidroside, and so on.
   Results: G, LLA, and G-LLA improved the amount of peripheral blood cells and bone marrow cells of myelosuppressed mice (P < 0.01). They significantly increased the colony quantity of colony-forming unit-granulocyte macrophage, burst-forming unit-erythroid, colony-forming unit-erythroid, and colony-forming unit-megakaryocyte and amount of G(2)/M and S phase cells (P < 0.01). They also significantly decreased the amount of hematopoiesis-related cytokines (P < 0.01). The content of chemical components in G-LLA changed, and the change of rare saponin was the most obvious.
   Conclusion: These results show that G-LLA herb pair might produce synergistic or complementary compatibility effects on bone marrow suppression after chemotherapy. It suggests that the substance basis of G-LLA for treating bone marrow suppression may be effective chemical components. (C) 2019 The Korean Society of Ginseng, Published by Elsevier Korea LLC.
C1 [Han, Jiahong; Dai, Min; Zhao, Yan; Cai, Enbo; Zhang, Lianxue; Jia, Xiaohuan; Sun, Nian; Fei, Xuan; Shu, Hui] Jilin Agr Univ, Coll Chinese Med Mat, 2888 Xincheng St, Changchun 130118, Jilin, Peoples R China.
C3 Jilin Agricultural University
RP Cai, EB (corresponding author), Jilin Agr Univ, Coll Chinese Med Mat, 2888 Xincheng St, Changchun 130118, Jilin, Peoples R China.; Zhang, LX (corresponding author), Jilin Agr Univ, Coll Chinese Med Mat, Xincheng St 2888, Changchun 130118, Jilin, Peoples R China.
EM caienbo126621@126.com
RI zhang, lianxue/LFU-9386-2024; Han, Jiahong/KHU-7070-2024; Zhao,
   Yan/KHU-0655-2024
FU National key R&D program, Key Technology Research of Ginseng Industry
   and Development of Great Health Products [2017YFC1702101]; national
   college students innovation and entrepreneurship training program of
   Jilin Agricultural University [201810193044]
FX This work was financially supported by National key R&D program, Key
   Technology Research of Ginseng Industry and Development of Great Health
   Products (grant No. 2017YFC1702101), and the national college students
   innovation and entrepreneurship training program of Jilin Agricultural
   University (project No. 201810193044).
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NR 50
TC 14
Z9 19
U1 12
U2 61
PU KOREAN SOC GINSENG
PI SEOCHO-GU
PA 1807 SEOCHO WORLD OFFICETEL, 1355-3 SEOCHO-DONG, SEOCHO-GU, SEOUL
   137-862, SOUTH KOREA
SN 1226-8453
EI 2093-4947
J9 J GINSENG RES
JI J. Ginseng Res.
PD MAR
PY 2020
VL 44
IS 2
BP 291
EP 299
DI 10.1016/j.jgr.2019.01.001
PG 9
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA KN4UW
UT WOS:000514835000013
PM 32148411
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Mirmazloum, I
   Kiss, A
   Ladányi, M
   György, Z
AF Mirmazloum, Iman
   Kiss, Attila
   Ladanyi, Marta
   Gyorgy, Zsuzsanna
TI Production of cinnamyl alcohol glycosides by biotransformation in
   roseroot callus cells
SO PLANT CELL TISSUE AND ORGAN CULTURE
LA English
DT Article
DE Cinnamyl alcohol glycosides; Precursor feeding; Cinnamyl alcohol;
   Rosavin; Rosarian; Rosin
ID RHODIOLA-ROSEA L.; AGGREGATE CULTURES; SALIDROSIDE; GLYCOSYLATION;
   TYROSOL; GROWTH; PLANTS; PART
AB Cinnamyl alcohol glycosides (CAGs) are the signature compounds of all roseroot preparations. The rapid growth in the market of roseroot-based products and the increasing demand for its raw material is causing serious threat for wild growing roseroot populations worldwide, which promotes the extensive studies to come up with alternative production resources. In this study the biotransformation of several precursors for the production of CAGs (rosin, rosavin, rosarin) in in vitro roseroot callus culture has been surveyed. Phenylalanine, trans-cinnamic acid, cinnamaldehyde and cinnamyl alcohol; the proposed precursors of CAGs, were added one by one to roseroot liquid callus cultures in 2 mM concentration. Samples were harvested and analysed by HPLC after 24, 48 and 96 h along with controls. All of the studied compounds, except phenylalanine, promoted the formation of CAGs. It was found that the closer the position of precursors to the final product in the biosynthesis pathway the more effective was the biotransformation into the final CAGs, both in terms of time and final product quantities. Addition of 2 mM trans-cinnamic acid and Cinnamyl alcohol resulted in 80-fold increase after 24 h and 130-fold increase after 96 h in callus samples, respectively. Rosin was the only compound which was released into the medium from the callus cells during the experiment and only in the cinnamyl alcohol-fed callus cells. These results revealed the potential of the precursors of the cinnamyl alcohol glycosides to be subject of biotransformation by roseroot callus cultures in order to produce the pharmaceutically important compounds.
   Key message Biotransformation of precursors in Rhodiola rosea callus culture has proved to be a feasible approach to sustainably enhance the content of active constituents in vitro.
C1 [Mirmazloum, Iman] Szent Istvan Univ, Dept Plant Physiol & Plant Biochem, Menesi Str 44, H-1118 Budapest, Hungary.
   [Mirmazloum, Iman; Kiss, Attila] Kaposvar Univ, Food Sci Innovat Ctr, Kaposvar, Hungary.
   [Ladanyi, Marta] Szent Istvan Univ, Dept Biometr & Agr Informat, Budapest, Hungary.
   [Gyorgy, Zsuzsanna] Szent Istvan Univ, Dept Genet & Plant Breeding, Budapest, Hungary.
C3 Hungarian University of Agriculture & Life Sciences; Kaposvar
   University; Hungarian University of Agriculture & Life Sciences;
   Hungarian University of Agriculture & Life Sciences; Hungarian
   University of Agriculture & Life Sciences
RP Mirmazloum, I (corresponding author), Szent Istvan Univ, Dept Plant Physiol & Plant Biochem, Menesi Str 44, H-1118 Budapest, Hungary.; Mirmazloum, I (corresponding author), Kaposvar Univ, Food Sci Innovat Ctr, Kaposvar, Hungary.
EM mirmazloum.iman@kertk.szie.hu
RI Ladanyi, Marta/AAX-9067-2021; György, Zsuzsanna/L-7105-2016; Mirmazloum,
   Iman/AAJ-5673-2020
OI Ladanyi, Marta/0000-0003-3114-8289; György,
   Zsuzsanna/0000-0002-7803-5487; Mirmazloum, Iman/0000-0002-1461-0382
FU Szent Istvan University (SZIE); Higher Education Institutional
   Excellence Program - Ministry of Human Capacities
   [20430-3/2018/FEKUTSTRAT];  [NKFIH-FK128793]
FX Open access funding provided by Szent Istvan University (SZIE). This
   research was supported by NKFIH-FK128793 project and the Higher
   Education Institutional Excellence Program (20430-3/2018/FEKUTSTRAT)
   awarded by the Ministry of Human Capacities within the framework of
   plant breeding and plant protection researches of Szent Istvan
   University.Dr.GabriellaSzalai (Centre for Agricultural Research,
   Hungarian Academy of Sciences) isacknowledged for performing the HPLC
   analysis.
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NR 34
TC 12
Z9 13
U1 0
U2 19
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0167-6857
EI 1573-5044
J9 PLANT CELL TISS ORG
JI Plant Cell Tissue Organ Cult.
PD OCT
PY 2019
VL 139
IS 1
BP 29
EP 37
DI 10.1007/s11240-019-01659-7
PG 9
WC Biotechnology & Applied Microbiology; Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Plant Sciences
GA IW9MC
UT WOS:000485316700003
OA hybrid
DA 2026-05-27
ER

PT J
AU Verpeut, JL
   Walters, AL
   Bello, NT
AF Verpeut, Jessica L.
   Walters, Amy L.
   Bello, Nicholas T.
TI Citrus aurantium and Rhodiola rosea in combination reduce
   visceral white adipose tissue and increase hypothalamic norepinephrine
   in a rat model of diet-induced obesity
SO NUTRITION RESEARCH
LA English
DT Article
DE Bitter orange; Golden root; Leptin; Diet supplement; Kaolin; Dopamine
ID BITTER ORANGE; SYNEPHRINE ALKALOIDS; INSULIN-RESISTANCE; P-SYNEPHRINE;
   WEIGHT-LOSS; EXTRACT; INHIBITION; ANOREXIA; STRESS
AB Extracts from the immature fruit of Citrus aurantium are often used for weight loss but are reported to produce adverse cardiovascular effects. Root extracts of Rhodiola rosea have notable antistress properties. The hypothesis of these studies was that C aurantium (6% synephrine) and R rosea (3% rosavins, 1% salidroside) in combination would improve diet-induced obesity alterations in adult male Sprague-Dawley rats. In normal-weight animals fed standard chow, acute administration of C aurantium (1-10 mg/kg) or R rosea (2-20 mg/kg) alone did not reduce deprivation-induced food intake, but C aurantium (5.6 mg/kg) + R rosea (20 mg/kg) produced a 10.5% feeding suppression. Animals maintained (13 weeks) on a highfat diet (60% fat) were exposed to 10-day treatments of C aurantium (5.6 mg/kg) or R rosea (20 mg/kg) alone or in combination. Additional groups received vehicle (2% ethanol) or were pair fed to the C aurantium + R rosea group. Although high-fat diet intake and weight loss were not influenced, C aurantium + R rosea had a 30% decrease in visceral fat weight compared with the other treatments. Only the C aurantium group had an increased heart rate (+7%) compared with vehicle. In addition, C aurantium + R rosea administration resulted in an elevation (+15%) in hypothalamic norepinephrine and an elevation (+150%) in frontal cortex dopamine compared with the pair-fed group. These initial findings suggest that treatments of C aurantium + R rosea have actions on central monoamine pathways and have the potential to be beneficial for the treatment of obesity. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Verpeut, Jessica L.; Walters, Amy L.; Bello, Nicholas T.] Rutgers State Univ, Dept Anim Sci, New Brunswick, NJ 08901 USA.
   [Verpeut, Jessica L.; Bello, Nicholas T.] Rutgers State Univ, Grad Program Endocrinol & Anim Biosci, New Brunswick, NJ 08901 USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University System; Rutgers University New Brunswick
RP Bello, NT (corresponding author), Rutgers State Univ, Sch Environm & Biol Sci, Dept Anim Sci, New Brunswick, NJ 08901 USA.
EM ntbello@aesop.rutgers.com
RI Verpeut, Jessica/AGS-5409-2022
OI Bello, Nicholas/0000-0001-5300-5604; Verpeut,
   Jessica/0000-0003-2941-7697
FU National Center for Complementary and Alternative Medicine
   [P50AT002776]; Office of Dietary Supplements
FX The authors would like to thank David Ribnicky for his assistance with
   the botanical extracts, Wes Darcy for his assistance with the CODA
   system, and Kathy Manger for her editorial comments and corrections. The
   project was supported by P50AT002776 from the National Center for
   Complementary and Alternative Medicine and the Office of Dietary
   Supplements, which funds the Botanical Research Center of Pennington
   Biomedical Research Center and the Department of Plant Biology and
   Pathology in the School of Environmental and Biological Sciences of
   Rutgers University.
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NR 39
TC 20
Z9 30
U1 0
U2 29
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
J9 NUTR RES
JI Nutr. Res.
PD JUN
PY 2013
VL 33
IS 6
BP 503
EP 512
DI 10.1016/j.nutres.2013.04.001
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 176PY
UT WOS:000321317800010
PM 23746567
OA Green Submitted
DA 2026-05-27
ER

PT J
AU Yuan, SJ
   Liu, J
   Sun, ZH
   Meng, LH
   Zhu, JY
   Wang, M
   Su, J
AF Yuan, Shaojing
   Liu, Jie
   Sun, Zhenhua
   Meng, Lihua
   Zhu, Jiying
   Wang, Min
   Su, Jie
TI RETRACTED: Effects of Self-Made Prescription Compound Rhodiola on the
   Ultrastructure of Podocytes in Rats with Type 2 Diabetic Nephropathy
   (Retracted Article)
SO EMERGENCY MEDICINE INTERNATIONAL
LA English
DT Article; Retracted Publication
ID SALIDROSIDE; CELL
AB Background. We attempt to discuss the function of self-made prescription compound Rhodiola rosea on the kidneys of rats with type 2 diabetic nephropathy (DN), through studying the effects of self-made rescription compound Rhodiola rosea on the ultrastructure of podocytes in rats with DN. Methods. DN rat model was established by streptozotocin. The successfully modeled rats were divided into 4 groups, DN group, compound Rhodiola low-dose group, medium-dose group, and high-dose group. Compound Rhodiola low-dose group, medium-dose group, and high-dose group were administered for 8 weeks, and the DN group and the blank control group were administered with normal saline. The podocyte count, podocyte width, podocyte fusion rate, and average thickness of glomerular basement membrane were compared in each group, and the ultrastructural changes in podocytes were observed by transmission electron microscope. Results. Compared with the normal control group, the number of podocytes in the DN group remarkably reduced, but the width level of podocyte, the fusion rate of podocyte, and the average thickness of basilar membrane remarkably increased (P < 0.05). Compared with the DN group, the number of podocytes in the high-, medium-, and low-dose groups increased remarkably, but the width level of podocyte, the fusion rate of podocyte, and the average thickness of basilar membrane decreased remarkably (P < 0.05). Compared with the low-dose group, the number of podocytes in the high-dose group and the medium-dose group increased remarkably, but the width of podocyte, the fusion rate of podocyte, as well as the average thickness of basilar membrane remarkably reduced (P < 0.05). Various indicators of high- and medium-dose groups had no statistical difference (P > 0.05). Conclusions. Self-made prescription compound Rhodiola rosea can promote the recovery of podocyte in DN rat and protect their kidney.
C1 [Yuan, Shaojing] Univ Shandong Tradit Chinese Med, Jinan 250355, Shandong, Peoples R China.
   [Yuan, Shaojing; Wang, Min] Shandong Univ Tradit Chinese Med, Affiliated Hosp 2, Dept Community Hlth Management, Jinan 250355, Shandong, Peoples R China.
   [Liu, Jie] Tradit Chinese Med Hosp Mengyin Cty, Dept 3, Dept Nephropathy & Oncol, Linyi 276200, Shandong, Peoples R China.
   [Sun, Zhenhua; Zhu, Jiying; Su, Jie] Shandong Univ Tradit Chinese Med, Affiliated Hosp 2, Dept Cadre Hlth Care, Jinan 250001, Shandong, Peoples R China.
   [Meng, Lihua] Shandong Univ Tradit Chinese Med, Affiliated Hosp 2, Jinan 250001, Shandong, Peoples R China.
C3 Shandong University of Traditional Chinese Medicine; Shandong University
   of Traditional Chinese Medicine; Shandong University of Traditional
   Chinese Medicine
RP Su, J (corresponding author), Shandong Univ Tradit Chinese Med, Affiliated Hosp 2, Dept Cadre Hlth Care, Jinan 250001, Shandong, Peoples R China.
EM sujie791020@hotmail.com
RI Meng, Lihua/N-3436-2015
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NR 16
TC 3
Z9 3
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2090-2840
EI 2090-2859
J9 EMERG MED INT
JI Emerg. Med. Int.
PD JUN 22
PY 2022
VL 2022
AR 3417557
DI 10.1155/2022/3417557
PG 7
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA 3U1DB
UT WOS:000840709200002
PM 35784643
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Senthilkumar, R
   Chandran, R
   Parimelazhagan, T
AF Senthilkumar, Ravichandran
   Chandran, Rahul
   Parimelazhagan, Thangaraj
TI Hepatoprotective effect of Rhodiola imbricata rhizome against
   paracetamol-induced liver toxicity in rats
SO SAUDI JOURNAL OF BIOLOGICAL SCIENCES
LA English
DT Article
DE Hepatotoxicity; In vivo antioxidants; Histopathology; Hematology;
   Biochemical markers
ID AQUEOUS EXTRACT; DOUBLE-BLIND; SALIDROSIDE; STRESS; EDGEW; ROSEA;
   FATIGUE; SHR-5
AB Rhodiola imbricata is a perennial herb of the family Crassulaceae, which has significant traditional usage as medicine and is also known to biosynthesize phytochemicals such as flavonoids, coumarins and phenyl glycosides. The present investigation was aimed to estimate the hepatoprotective activity of R. imbricata rhizome acetone extract against paracetamol (2 g/kg) induced liver toxicity. Paracetamol was administered to induce hepatic damage in Wistar rats. 200 and 400 mg/kg doses of rhizome acetone extract and silymarin (25 mg/kg) were used as treatment groups. The blood samples were analyzed for biochemical markers of hepatic injury and tissue samples were subjected for estimation of liver antioxidants and histopathological studies. Analysis of the extract treated rats (400 mg/kg) showed an elevation of superoxide dismutase (0.326 units/min/mg protein), catalase (185.03 mu mole of H2O2 consumed/min/mg protein), glutothione peroxidase (19.26 mg GSH consumed/min/mg protein) and reduced glutathione (16.2 mu mole of GSH/mg protein). Moreover, the biochemical parameters in serum like alkaline phosphatase, serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT) and lipid profiles were also improved in treated groups compared to the control. The oral administration of different doses of rhizome acetone extract significantly protected the hepatic cells from damage. The hematological and biochemical parameters were also normal in extract treated rats compared to the control and standard (silymarin) groups. The HPLC analysis revealed the presence of some important phenolic compounds which could be responsible for the hepatoprotective activity. This study proved that R. imbricata could be taken as a good natural source of the hepatoprotective agent. (C) 2014 Production and hosting by Elsevier B.V. on behalf of King Saud University.
C1 [Senthilkumar, Ravichandran; Chandran, Rahul; Parimelazhagan, Thangaraj] Bharathiar Univ, Dept Bot, Bioprospecting Lab, Coimbatore, Tamil Nadu, India.
C3 Bharathiar University
RP Parimelazhagan, T (corresponding author), Bharathiar Univ, Dept Bot, Bioprospecting Lab, Coimbatore, Tamil Nadu, India.
EM drparimel@gmail.com
RI ; Thangaraj, Parimelazhagan/AAD-6861-2021; Chandran, Rahul/U-5632-2019
OI , Senthilkumar Ravichanan/0000-0003-1823-5310; Thangaraj,
   Parimelazhagan/0000-0002-5874-8949; 
FU DRDO-DIHAR, Govt. of India
FX The authors are thankful to the DRDO-DIHAR, Govt. of India for the
   financial support.
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NR 35
TC 44
Z9 59
U1 1
U2 23
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1319-562X
J9 SAUDI J BIOL SCI
JI Saudi J. Biol. Sci.
PD NOV
PY 2014
VL 21
IS 5
BP 409
EP 416
DI 10.1016/j.sjbs.2014.04.001
PG 8
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA AR2KR
UT WOS:000343414800004
PM 25313275
OA hybrid
DA 2026-05-27
ER

PT J
AU Tang, L
   Guo, DY
   Jia, DY
   Piao, SL
   Fang, CQ
   Zhu, YY
   Wang, YH
   Pan, Z
AF Tang, Lu
   Guo, Dingyuan
   Jia, Dongye
   Piao, Songlan
   Fang, Chunqiu
   Zhu, Yueya
   Wang, Yinghang
   Pan, Zhi
TI Exploring the therapeutic potential of "Tianyu" medicine pair in
   rheumatoid arthritis: an integrated study combining LC-MS/MS,
   bioinformatics, network pharmacology, and experimental validation
SO FRONTIERS IN MEDICINE
LA English
DT Article
DE rheumatoid arthritis; "Tianyu" medicine pair; Chinese medicine;
   bioinformatics analysis; machine learning
ID FIBROBLAST-LIKE SYNOVIOCYTES; B-CELLS; ROLES; GENE; IDENTIFICATION;
   EXPRESSION; STRESS; SYSTEM; NCF1
AB Background Rheumatoid arthritis (RA) is a widespread chronic autoimmune disease that primarily causes joint inflammation and damage. In advanced stages, RA can result in joint deformities and loss of function, severely impacting patients' quality of life. The "Tianyu" pair (TYP) is a traditional Chinese medicine formulation developed from clinical experience and has shown some effectiveness in treating RA. However, its role in the complex biological mechanisms underlying RA remains unclear and warrants further investigation.Methods We obtained gene sequencing data of synovial tissues from both RA patients and healthy individuals using two gene microarrays, GSE77298 and GSE55235, from the GEO database. Through an integrated approach involving bioinformatics, machine learning, and network pharmacology, we identified the core molecular targets of the "Tianyu" medicine pair (TYP) for RA treatment. Liquid chromatography-mass spectrometry was then employed to analyze the chemical components of TYP. To validate our findings, we conducted animal experiments with Wistar rats, comparing histopathological and key gene expression changes before and after TYP treatment.Results Our data analysis suggests that the onset of RA may be associated with inflammation-related immune cells involved in both adaptive and innate immune responses. Potential key targets for TYP treatment in RA include AKR1B10, MMP13, FABP4, NCF1, SPP1, COL1A1, and RASGRP1. Among the components of TYP, Kaempferol, Quercetin, and Salidroside were identified as key, with MMP13 and NCF1 showing the strongest binding affinity to these compounds. Animal experiments confirmed the findings from bioinformatics and network pharmacology, validating the key targets and therapeutic effects of TYP in treating RA.Conclusion Our study reveals that TYP has potential clinical value in the treatment of rheumatoid arthritis. This research enhances our understanding of RA's pathogenesis and provides insight into potential therapeutic mechanisms.
C1 [Tang, Lu; Jia, Dongye; Fang, Chunqiu; Zhu, Yueya; Pan, Zhi] Changchun Univ Chinese Med, Jilin Ginseng Acad, Fangzheng Res Lab, Changchun, Peoples R China.
   [Guo, Dingyuan] Beijing Univ Chinese Med, Dongzhimen Hosp, Dept Tradit Chinese Internal Med, Beijing, Peoples R China.
   [Piao, Songlan] Changchun Univ Chinese Med, Clin Med Sch, Dept Pathol Teaching & Res, Changchun, Peoples R China.
   [Wang, Yinghang] Changchun Univ Chinese Med, Affiliated Hosp, Dept Rheumatol & Immunol, Changchun, Peoples R China.
C3 Changchun University of Chinese Medicine; Beijing University of Chinese
   Medicine; Changchun University of Chinese Medicine; Changchun University
   of Chinese Medicine
RP Pan, Z (corresponding author), Changchun Univ Chinese Med, Jilin Ginseng Acad, Fangzheng Res Lab, Changchun, Peoples R China.; Wang, YH (corresponding author), Changchun Univ Chinese Med, Affiliated Hosp, Dept Rheumatol & Immunol, Changchun, Peoples R China.
EM panzhiwyh@sohu.com; 13596030117@126.com
OI pan, zhi/0009-0006-3798-0825
FU National Natural Science Foundation of China10.13039/501100001809;
   National Natural Science Foundation of China; Natural Science Foundation
   of Jilin Province
FX The authors would like to acknowledge the support provided by the
   National Natural Science Foundation of China and the Natural Science
   Foundation of Jilin Province. No AI-generated content was used in this
   study. The ChatGPT-4 model was only utilized to enhance the readability
   of the article.
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NR 53
TC 5
Z9 6
U1 4
U2 21
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD OCT 4
PY 2024
VL 11
AR 1475239
DI 10.3389/fmed.2024.1475239
PG 16
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA J2E3O
UT WOS:001335247500001
PM 39430588
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Luan, RQ
   Zhao, P
   Zhang, XL
   Li, QQ
   Chen, XF
   Wang, L
AF Luan, Ruqiao
   Zhao, Pan
   Zhang, Xuelan
   Li, Qinqing
   Chen, Xinfeng
   Wang, Ling
TI Pharmacodynamics, Pharmacokinetics, and Kidney Distribution of Raw and
   Wine-Steamed Ligustri Lucidi Fructus Extracts in Diabetic Nephropathy
   Rats
SO MOLECULES
LA English
DT Article
DE Ligustri Lucidi Fructus extract; wine-steaming; pharmacodynamics;
   pharmacokinetics; kidney distribution; diabetic nephropathy rats
ID HIGH-FAT DIET; AQUEOUS EXTRACTS; IN-VITRO; COMPLICATIONS; COMBINATION;
   MODEL
AB The purpose of this study was to investigate differences in the pharmacodynamic, pharmacokinetic, and kidney distribution between Ligustri Lucidi Fructus (LLF) and wine-steamed Ligustri Lucidi Fructus (WLL) extracts in diabetic nephropathy (DN) rats. The DN rats were induced by high-fat-sugar diet (HFSD)/streptozotocin (STZ) regimen. For pharmacodynamics, the DN rats were treated with LLF and WLL extracts to assess the anti-diabetic nephropathy effects. For pharmacokinetics and kidney distribution, the concentrations of drugs (hydroxytyrosol, salidroside, nuezhenidic acid, oleoside-11-methyl ester, specnuezhenide, 1"'-O-beta-d-glucosylformoside, G13, and oleonuezhenide) were determined. Regarding the pharmacodynamics, LLF and WLL extracts decreased the levels of blood glucose, serum creatinine (SCr), blood urea nitrogen (BUN), and 24-h urinary protein (24-h Upro) in DN rats. Furthermore, LLF and WLL extracts increased the level of high-density lipoprotein cholesterol (HDL-C); decreased the levels of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C); and reduced levels of pro-inflammatory cytokines (IL-1 beta, TNF-alpha, and IL-6) in DN rats. The anti-diabetic nephropathy effect of the WLL extract was better than that of the LLF extract. Regarding the pharmacokinetic and kidney tissue distribution, there were obvious differences in the eight ingredients between LLF and WLL extracts in DN rats. LLF and WLL extracts had protective effects on DN rats, while the WLL extract was better than the LLF extract regarding anti-diabetic nephropathy effects. The pharmacokinetic parameters and kidney distribution showed that wine-steaming could affect the absorption and distribution of the eight ingredients. The results provided a reasonable basis for the study of the clinical application and processing mechanism of LLF.
C1 [Luan, Ruqiao] Shandong Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Jinan 250355, Peoples R China.
   [Zhao, Pan; Zhang, Xuelan; Chen, Xinfeng; Wang, Ling] Shandong Univ Tradit Chinese Med, Sch Pharm, Jinan 250355, Peoples R China.
   [Zhang, Xuelan] Shandong Prov Collaborat Innovat Ctr Qual Control, Jinan 250355, Peoples R China.
   [Li, Qinqing] Shanxi Univ Chinese Med, Sch Pharm, Jinzhong 030619, Peoples R China.
C3 Shandong University of Traditional Chinese Medicine; Shandong University
   of Traditional Chinese Medicine; Shanxi University of Chinese Medicine
RP Zhang, XL (corresponding author), Shandong Univ Tradit Chinese Med, Sch Pharm, Jinan 250355, Peoples R China.; Zhang, XL (corresponding author), Shandong Prov Collaborat Innovat Ctr Qual Control, Jinan 250355, Peoples R China.
EM 60030065@sdutcm.edu.cn
FU National Key Research and Development Program of China [2018YFC1707204];
   National Natural Science Foundation of China [81973486, 82173974,
   81373968]; Shandong Provincial Collaborative Innovation Center Project
   for Quality Control and Construction of the Whole Industrial Chain of
   Traditional Chinese Medicine [CYLXTCX2021-12]
FX This research was funded by the National Key Research and Development
   Program of China (Grant No. 2018YFC1707204), the National Natural
   Science Foundation of China (No. 81973486, 82173974, and 81373968), and
   the Shandong Provincial Collaborative Innovation Center Project for
   Quality Control and Construction of the Whole Industrial Chain of
   Traditional Chinese Medicine (CYLXTCX2021-12).
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NR 51
TC 14
Z9 18
U1 2
U2 33
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD JAN
PY 2023
VL 28
IS 2
AR 791
DI 10.3390/molecules28020791
PG 21
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 8A7ID
UT WOS:000916407800001
PM 36677849
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Dinel, AL
   Guinobert, I
   Lucas, C
   Blondeau, C
   Bardot, V
   Ripoche, I
   Berthomier, L
   Pallet, V
   Laye, S
   Joffre, C
AF Dinel, Anne-Laure
   Guinobert, Isabelle
   Lucas, Celine
   Blondeau, Claude
   Bardot, Valerie
   Ripoche, Isabelle
   Berthomier, Lucile
   Pallet, Veronique
   Laye, Sophie
   Joffre, Corinne
TI Reduction of acute mild stress corticosterone response and changes in
   stress-responsive gene expression in male Balb/c mice after repeated
   administration of a Rhodiola rosea L. root extract
SO FOOD SCIENCE & NUTRITION
LA English
DT Article
DE acute mild stress; circadian rhythm; corticosterone; nutritional
   supplementation; rhodiola
ID DEPRESSIVE-LIKE BEHAVIOR; GLUCOCORTICOID-RECEPTOR; RAT HIPPOCAMPUS;
   SYNAPTIC PLASTICITY; DOUBLE-BLIND; ACTIVATION; ADAPTOGENS; SHR-5;
   SALIDROSIDE; ANXIETY
AB Rhodiola rosea L. (R. rosea) is an adaptogenic plant increasing body resistance to stress. Its efficacy has been evidenced mainly in chronic stress models, data concerning its effect in acute stress and underlying mechanisms being scarce. The objective was to investigate the effect of repeated doses of a R. rosea hydroethanolic root extract (HRE) on hypothalamic pituitary adrenal response in a murine model of acute mild stress and also the mechanisms involved. Stress response was measured in Balb/c mice having received by gavage HRE (5 g/kg) or vehicle daily for 2 weeks before being submitted to an acute mild stress protocol (open-field test then elevated plus maze). Corticosterone was measured in plasma from mandibular vein blood drawn before and 30, 60, and 90 min after initiation of the stress protocol. Mice were sacrificed at 90 min, and the hippocampus, prefrontal cortex, and amygdala were excised for high-frequency RT-PCR gene expression analysis. At 30 min after acute mild stress induction, corticosterone level in mice having received the HRE was lower than in control mice and comparable to that in nonstressed mice in the HRE group. HRE administration induced brain structure-dependent changes in expression of several stress-responsive genes implicated in neuronal structure, HPA axis activation, and circadian rhythm. In the acute mild stress model used, R. rosea HRE decreased corticosterone level and increased expression of stress-responsive genes, especially in the hippocampus and prefrontal cortex. These findings suggest that R. rosea HRE could be of value for modulating reactivity to acute mild stress.
C1 [Dinel, Anne-Laure; Pallet, Veronique; Laye, Sophie; Joffre, Corinne] INRA, Integrated Nutr & Neurobiol, UMR 1286, F-33076 Bordeaux, France.
   [Dinel, Anne-Laure; Pallet, Veronique; Laye, Sophie; Joffre, Corinne] Bordeaux Univ, Integrated Nutr & Neurobiol, UMR 1286, Bordeaux, France.
   [Dinel, Anne-Laure; Lucas, Celine] NutriBrain Res & Technol Transfer, Integrated Nutr & Neurobiol, UMR 1286, Bordeaux, France.
   [Guinobert, Isabelle; Blondeau, Claude; Bardot, Valerie] Grp Pileje, Paris, France.
   [Guinobert, Isabelle; Blondeau, Claude; Bardot, Valerie] Naturopole, St Bonnet De Rochefort, France.
   [Ripoche, Isabelle; Berthomier, Lucile] Clermont Auvergne Univ, Clermont Ferrand Chem Inst, SIGMA Clermont, CNRS, Clermont Ferrand, France.
C3 Universite de Bordeaux; INRAE; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite de Bordeaux; Institut National
   de la Sante et de la Recherche Medicale (Inserm); Institut National de
   la Sante et de la Recherche Medicale (Inserm); Universite de Bordeaux;
   Universite Clermont Auvergne (UCA); Centre National de la Recherche
   Scientifique (CNRS)
RP Dinel, AL (corresponding author), INRA, Integrated Nutr & Neurobiol, UMR 1286, F-33076 Bordeaux, France.
EM anne-laure.dinel@inra.fr
RI Laye, Sophie/AAX-2501-2020
OI Laye, Sophie/0000-0002-3843-1012
FU Groupe PiLeJe
FX This work was funded by Groupe PiLeJe. Financial support was provided to
   Sigma Clermont for the performance of the chromatographic analyses and
   to INRA/Nutribrain for the conduct of in vivo experiments (service
   provision). The specific roles of the authors including Isabelle
   Guinobert, Claude Blondeau, and Valerie Bardot from Groupe PiLeJe are
   articulated in the "author contributions" section.
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NR 66
TC 14
Z9 18
U1 0
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2048-7177
J9 FOOD SCI NUTR
JI Food Sci. Nutr.
PD NOV
PY 2019
VL 7
IS 11
BP 3827
EP 3841
DI 10.1002/fsn3.1249
EA OCT 2019
PG 15
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA JL6TB
UT WOS:000494114700001
PM 31763032
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Hao, SJ
   Yang, YY
   Han, AL
   Chen, JA
   Luo, XY
   Fang, GZ
   Liu, JF
   Wang, S
AF Hao, Sijia
   Yang, Yayu
   Han, Ailing
   Chen, Jianan
   Luo, Xiaoyu
   Fang, Guozhen
   Liu, Jifeng
   Wang, Shuo
TI Glycosides and Their Corresponding Small Molecules Inhibit Aggregation
   and Alleviate Cytotoxicity of Aβ40
SO ACS CHEMICAL NEUROSCIENCE
LA English
DT Article
DE Alzheimer's disease; fibrils; A beta 40; glycoside inhibitor; molecular
   docking
ID ANTI-AMYLOIDOGENIC COMPOUNDS; ALZHEIMERS-DISEASE; FIBRILLATION;
   BIOAVAILABILITY; GLYCOSYLATION; SOLUBILITY; METABOLISM; FLAVONOIDS;
   MECHANISM; TOXICITY
AB Polyphenols are the class of naturally synthesized compounds in the secondary metabolism of plants, which are widely distributed in fruits and vegetables. Their potential health treatment strategies have attracted wide attention in the scientific community. The abnormal aggregation of Afi to form mature fibrils is pathologically related to Alzheimer's disease (AD). Therefore, inhibiting A beta 40 fibrillogenesis was considered to be the major method for the intervention and therapy of AD. Glycosides, as a cluster of natural phenolic compounds, are widely distributed in Chinese herbs, fruits, and vegetables. The inhibitory effect of glycosides (phloridzin, salidroside, polydatin, geniposide, and gastrodin) and their corresponding small molecules (phloretin, 4-hydroxyphenyl ethanol, resveratrol, genipin, and 4-hydroxybenzyl alcohol) on A beta 40 aggregation and fibrils prolongation, disaggregation against mature fibrils, and the resulting cytotoxicity were studied by systematical biochemical, cell biology and molecular docking techniques, respectively. As a result, all inhibitors were observed against A beta 40 aggregation and fibrils prolongation and disaggregated mature A beta 40 fibrils in a dose-dependent manner. Besides, the cell validity experiments also showed that all inhibitors could effectively alleviate the cytotoxicity induced by A beta 40 aggregates, and the glycoside groups played important roles in this inhibiting process. Finally, molecular docking was performed to study the interactions between these inhibitors and A beta 40. Docking showed that all inhibitors were bound to the similar region of A beta 40, and glycoside group formed hydrogen bonds with the pivotal residues Lys16. These results indicated that the glycoside groups could increase the inhibitory effects and reduce cytotoxicity. Glycosides have tremendous potential to be developed as an innovative type of aggregation inhibitor to control and treat neurodegenerative diseases.
C1 [Hao, Sijia; Yang, Yayu; Han, Ailing; Chen, Jianan; Luo, Xiaoyu; Fang, Guozhen; Liu, Jifeng; Wang, Shuo] Tianjin Univ Sci & Technol, Coll Food Sci & Engn, State Key Lab Food Nutr & Safety, Key Lab Food Qual & Hlth Tianjin, Tianjin 300457, Peoples R China.
   [Wang, Shuo] Nankai Univ, Res Ctr Food Sci & Human Hlth, Sch Med, Tianjin 300071, Peoples R China.
C3 Tianjin University of Science & Technology; Nankai University
RP Liu, JF; Wang, S (corresponding author), Tianjin Univ Sci & Technol, Coll Food Sci & Engn, State Key Lab Food Nutr & Safety, Key Lab Food Qual & Hlth Tianjin, Tianjin 300457, Peoples R China.; Wang, S (corresponding author), Nankai Univ, Res Ctr Food Sci & Human Hlth, Sch Med, Tianjin 300071, Peoples R China.
EM liujifeng111@gmail.com; s.wang@tust.edu.cn
FU Natural Science Foundation of China [21575102]; National Key Research
   and Development Program of China [2020YFF0305002]
FX This work was supported by the Natural Science Foundation of China
   (funding, 21575102) and the National Key Research and Development
   Program of China (project no. 2020YFF0305002).
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NR 49
TC 13
Z9 13
U1 4
U2 50
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1948-7193
J9 ACS CHEM NEUROSCI
JI ACS Chem. Neurosci.
PD MAR 16
PY 2022
VL 13
IS 6
BP 766
EP 775
DI 10.1021/acschemneuro.1c00729
PG 10
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Neurosciences
   & Neurology
GA ZY9VU
UT WOS:000772927600006
PM 35230090
DA 2026-05-27
ER

PT J
AU Ji, MY
   Wang, CC
   Yang, TY
   Meng, XX
   Wang, XQ
   Li, MH
AF Ji, Mingyue
   Wang, Congcong
   Yang, Tieyi
   Meng, Xiangxi
   Wang, Xiaoqin
   Li, Minhui
TI Integrated Phytochemical Analysis Based on UPLC-MS/MS and Network
   Pharmacology Approaches to Explore the Effect of Odontites
   vulgaris Moench on Rheumatoid Arthritis
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE Odontites vulgaris; rheumatoid arthritis; UPLC-MS; MS; network
   pharmacology; PI3k-Akt signal pathway; RAW 264; 7
ID CHEMICAL-CONSTITUENTS; RAT PLASMA; NATURAL-PRODUCTS; ESI-MS/MS;
   IRIDOIDS; PHARMACOKINETICS; ANTIOXIDANT; KAEMPFEROL; COMPONENTS
AB Odontites vulgaris Moench has the effect of clearing away heat, detoxification, dispelling wind, and clearing dampness. In this study, the potential anti-inflammatory compounds of O. vulgaris were investigated using ultra-high-performance liquid chromatography-mass spectrometry (UPLC-MS/MS) combined with the network pharmacology approach and further confirmed on an LPS-activated RAW 264.7 macrophage model. Monomer compounds were prepared from the active fraction using modern advanced separation and purification methods. UPLC-Q-Exactive HRMS was used to identify the chemical compounds in the active fractions of O. vulgaris. D-mannitol, geniposidic acid, salidroside, shanzhiside methyl ester, eleutheroside B, geniposide, 7,8-dihydroxycoumarin, gardoside methyl ester, arenarioside, vanillic acid, p-hydroxy-cinnamic acid, melampyroside, syringaresinol, tricin, and diosmetin were isolated from O. vulgaris for the first time. A compound database of O. vulgaris was established based on the existing literature to predict the mechanism of O. vulgaris in the treatment of rheumatoid arthritis. The results suggest that the PI3K-Akt pathway mediates O. vulgaris and deserves more attention in the treatment of RA. Finally, the anti-rheumatoid arthritis effects of the four target compounds were validated with the decreased levels of NO, TNF-alpha, IL-6 and IL-1 beta in RAW 264.7 macrophage cells treated with LPS. The present study explored the potential targets and signaling pathways of O. vulgaris in the treatment of RA, which may help to illustrate the mechanisms involved in the action of O. vulgaris and may provide a better understanding of the relationship between O. vulgaris and RA. This study provides novel insights into the development of new drugs and utilization of Mongolian traditional Chinese medicine resources.
C1 [Ji, Mingyue; Wang, Congcong; Meng, Xiangxi; Li, Minhui] Baotou Med Coll, Inner Mongolia Key Lab Characterist Geoherbs Reso, Baotou, Peoples R China.
   [Yang, Tieyi] Inner Mongolia Med Univ, Affiliated Hosp 2, Trauma Orthoped, Hohhot, Peoples R China.
   [Wang, Xiaoqin; Li, Minhui] Inner Mongolia Med Univ, Dept Pharm, Hohhot, Peoples R China.
   [Li, Minhui] Inner Mongolia Inst Tradit Chinese Med, Hohhot, Peoples R China.
   [Li, Minhui] Key Lab Resourceol Chinese Med Mat, Baotou, Peoples R China.
   [Li, Minhui] Inner Mongolia Engn Res Ctr Planting & Dev Astrag, Baotou, Peoples R China.
C3 Baotou Medical College; Inner Mongolia Medical University; Inner
   Mongolia Medical University
RP Li, MH (corresponding author), Baotou Med Coll, Inner Mongolia Key Lab Characterist Geoherbs Reso, Baotou, Peoples R China.; Wang, XQ; Li, MH (corresponding author), Inner Mongolia Med Univ, Dept Pharm, Hohhot, Peoples R China.; Li, MH (corresponding author), Inner Mongolia Inst Tradit Chinese Med, Hohhot, Peoples R China.; Li, MH (corresponding author), Key Lab Resourceol Chinese Med Mat, Baotou, Peoples R China.; Li, MH (corresponding author), Inner Mongolia Engn Res Ctr Planting & Dev Astrag, Baotou, Peoples R China.
EM nywangxiaoqin@163.com; prof_liminhui@yeah.net
RI meng, xiangxi/ABB-8593-2020
FU National Natural Science Foundation of China [81874336]; China
   Agriculture Research System [CARS-21]; 2019 Medical Service and Security
   Capacity Enhancement Subsidy Project [(2019) 39]
FX This research was funded by the National Natural Science Foundation of
   China (Grant No. 81874336), China Agriculture Research System (Grant No.
   CARS-21), 2019 Medical Service and Security Capacity Enhancement Subsidy
   Project (Grant No. Finance Society (2019) 39).
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NR 80
TC 18
Z9 21
U1 5
U2 98
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD AUG 30
PY 2021
VL 12
AR 707687
DI 10.3389/fphar.2021.707687
PG 24
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA UT1OM
UT WOS:000697892600001
PM 34526896
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Tian, T
   Zhou, BW
   Wu, LH
   Zhang, F
   Chou, GX
   Feng, CG
   Lin, GQ
AF Tian, Tian
   Zhou, Bo-wen
   Wu, Li-hong
   Zhang, Fang
   Chou, Gui-xin
   Feng, Chen-guo
   Lin, Guo-qiang
TI Non-targeted screening of pyranosides in Rhodiola crenulata using
   an all ion fragmentation-exact neutral loss strategy combined with
   liquid chromatography-quadrupole time-of-flight mass spectrometry
SO PHYTOCHEMICAL ANALYSIS
LA English
DT Article
DE all ion fragmentation&#8208; exact neutral loss; LC&#8208; QTOF&#8208;
   MS; non&#8208; targeted screening; pyranosides; Rhodiola crenulata
ID SALIDROSIDE; IDENTIFICATION; QUANTIFICATION; SPECTROSCOPY; ACQUISITION;
   EXTRACT; SWATH; SCANS
AB Introduction Pyranosides as one kind of natural glycosides contain a pyran ring linked to an aglycone in the structure. They occur widely in plants and possess diverse biological activities. The discovery of new pyranosides not only contributes to research on natural products but also may promote pharmaceutical development.
   Objectives A non-targeted liquid chromatography-quadrupole time-of-flight mass spectrometry method coupled with an all ion fragmentation-exact neutral loss (AIF-ENL) strategy was developed for the screening of pyranosides in plants.
   Methods Pyranosides in various types were collected as a model. The AIF-ENL strategy comprised three steps: AIF spectrum acquisition and generation, ENL-based searching and identification, and confirmation of structural type using target second-stage mass spectrometry (MS/MS). The strategy was systematically evaluated based on the matrix effects, fragmentation stability, scan rate and screening efficiency and finally applied to Rhodiola crenulata (Hook. f. et Thoms) H. Ohba.
   Results The method was proved to be an efficient tool for the screening of pyranosides. When it was applied to R. crenulata, a total of 24 pyranoside candidates were detected. Among them, six were tentatively identified on the basis of the agreement of their elemental composition with the reported. The other 18 were detected in R. crenulata for the first time.
   Conclusion The method offers a new platform for discovering pyranosides. In addition, the developed non-targeted strategy can also be used for other natural products, such as flavonoids and coumarins, as long as there is a common fragmentation behaviour in their MS/MS to generate characteristic neutral losses or fragments.
C1 [Tian, Tian; Zhang, Fang; Feng, Chen-guo; Lin, Guo-qiang] Shanghai Univ Tradit Chinese Med, Res Ctr Chiral Drugs, Innovat Res Inst Tradit Chinese Med, 1200 Cailun Rd, Shanghai 201203, Peoples R China.
   [Zhou, Bo-wen; Zhang, Fang; Feng, Chen-guo; Lin, Guo-qiang] Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai, Peoples R China.
   [Wu, Li-hong; Chou, Gui-xin] Shanghai Univ Tradit Chinese Med, Inst Chinese Mat Med, 1200 Cailun Rd, Shanghai 201203, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Chinese Academy of
   Sciences; Shanghai Institute of Organic Chemistry, CAS; Shanghai
   University of Traditional Chinese Medicine
RP Zhang, F; Feng, CG (corresponding author), Shanghai Univ Tradit Chinese Med, Res Ctr Chiral Drugs, Innovat Res Inst Tradit Chinese Med, 1200 Cailun Rd, Shanghai 201203, Peoples R China.; Chou, GX (corresponding author), Shanghai Univ Tradit Chinese Med, Inst Chinese Mat Med, 1200 Cailun Rd, Shanghai 201203, Peoples R China.
EM fzhang@shutcm.edu.cn; chouguixinzyb@126.com; fengcg@shutcm.edu.cn
RI ; Zhang, Fang/GLN-6971-2022
OI ?, ?/0000-0002-9363-9473; Feng, Chenguo/0000-0001-9899-9489; Zhou,
   Bowen/0009-0001-0301-1114
FU Science and Technology Commission of Shanghai Municipality
   [18401933500]; Shanghai Municipal Education Commission
   [2019-01-00-10-E00072]
FX Science and Technology Commission of Shanghai Municipality, Grant/Award
   Number: 18401933500; Shanghai Municipal Education Commission,
   Grant/Award Number: 2019-01-00-10-E00072
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NR 67
TC 7
Z9 7
U1 4
U2 47
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0958-0344
EI 1099-1565
J9 PHYTOCHEM ANALYSIS
JI Phytochem. Anal.
PD NOV
PY 2021
VL 32
IS 6
BP 1039
EP 1050
DI 10.1002/pca.3045
EA MAR 2021
PG 12
WC Biochemical Research Methods; Plant Sciences; Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Plant Sciences; Chemistry
GA WD6LZ
UT WOS:000634032300001
PM 33779008
DA 2026-05-27
ER

PT J
AU Seo, EJ
   Fischer, N
   Efferth, T
AF Seo, Ean-Jeong
   Fischer, Nicolas
   Efferth, Thomas
TI Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer's
   disease
SO PHARMACOLOGICAL RESEARCH
LA English
DT Review
DE Botanicals; Cognitive impairment; Natural products; Neurodegenerative
   diseases; Medicinal plants; Small molecule inhibitor
ID TRANS-RETINOIC ACID; INDUCED MICROGLIAL ACTIVATION; PLANT ALKALOID
   TETRANDRINE; GAMMA-SECRETASE MODULATORS; PEROXIDE-INDUCED APOPTOSIS;
   MILD COGNITIVE IMPAIRMENT; AMYLOID-BETA PEPTIDE; OXIDATIVE STRESS;
   A-BETA; INFLAMMATORY RESPONSES
AB Alzheimer's disease (AD) is the most prevalent form of dementia. The exact pathophysiology of this disease remains incompletely understood and safe and effective therapies are required. AD is highly correlated with neuroinflammation and oxidative stress in brain causing neuronal loss. Nuclear factor of activated B-cells (NF-kappa B) is involved in physiological inflammatory processes and thus representing a promising target for inflammation-based AD therapy.
   Phytochemicals are able to interfere with the NF-kappa B pathway. They inhibit the phosphorylation or the ubiquitination of signaling molecules, and thus, inhibit the degradation of I kappa B. The translocation of NF-kappa B to the nucleus and subsequent transcription of pro-inflammatory cytokines are inhibited by the actions of phytochemicals. Additionally, natural compounds preventing the interaction of NF-kappa B can block NF-kappa B's transcriptional activity by inhibiting its binding to target DNA.
   Many polyphenols including curcumin, resveratrol, pterostilbene, punicalagin, macranthoin G, salidroside, 4-O-methylhonokiol, lycopene, genistein, obovatol and gallic acid were reported as potent NF-kappa B inhibitors for AD treatment. Several alkaloids such as galantamine, glaucocalyxin B, tetrandrine, berberine, oridonin, anatabine have been shown anti-inflammatory effects in AD models in vitro as well as in vivo. Besides, vitamins, tanshinone IIA, artemisinin, dihydroasparagusic acid, geniposide, xanthocera-side, L-theranine, 1,8-cineole and paeoniflorin were described as promising NF-kappa B inhibitors.
   In conclusion, natural products from plants represent interesting candidates for AD treatment. They may qualify as promising compounds for the development of derivatives providing enhanced pharmacological features. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Seo, Ean-Jeong; Fischer, Nicolas; Efferth, Thomas] Johannes Gutenberg Univ Mainz, Inst Pharm & Biochem, Dept Pharmaceut Biol, Mainz, Germany.
C3 Johannes Gutenberg University of Mainz
RP Efferth, T (corresponding author), Johannes Gutenberg Univ Mainz, Inst Pharm & Biochem, Staudinger Weg 5, D-55128 Mainz, Germany.
EM efferth@uni.mainz.de
OI Efferth, Thomas/0000-0002-2637-1681; Efferth, Thomas/0000-0002-3096-3292
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NR 256
TC 230
Z9 257
U1 7
U2 269
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
EI 1096-1186
J9 PHARMACOL RES
JI Pharmacol. Res.
PD MAR
PY 2018
VL 129
BP 262
EP 273
DI 10.1016/j.phrs.2017.11.030
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GA1UJ
UT WOS:000428102600026
PM 29179999
DA 2026-05-27
ER

PT J
AU Jiang, Q
   Yi, M
   Guo, QQ
   Wang, CM
   Wang, HM
   Meng, SS
   Liu, C
   Fu, YL
   Ji, H
   Chen, T
AF Jiang, Qi
   Yi, Min
   Guo, Qianqian
   Wang, Ciman
   Wang, Huimin
   Meng, Shanshan
   Liu, Chao
   Fu, Yeliu
   Ji, Hui
   Chen, Tong
TI Protective effects of polydatin on lipopolysaccharide-induced acute lung
   injury through TLR4-MyD88-NF-κB pathway
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE Polydatin; LPS; ALI; BEAS-2B cells; Cytokines; TLR4-MyD88-NF-kappa B
   pathway
ID RAW 264.7 CELLS; IN-VIVO; EPITHELIAL-CELLS; PLATYCODIN D; MICE;
   INFLAMMATION; SALIDROSIDE; DISEASE; VITRO; INTERLEUKIN-8
AB The purpose of this study was to investigate the protective effect of PD against lipopolysaccharide (LPS)-induced acute lung injury (ALI) and explore its potential mechanism. In vivo, PD and dexamethasone were intraperitoneally administered 1 h before LPS stimulation. Then, mice were sacrificed at 6 h post-LPS stimulation. Neutrophil number, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1 beta (IL-1 beta) in bronchoalveolar lavage fluid (BALF) were determined, as well as lung wet to dry ratio (W/D) and polymorphonuclear (MPO) activity. The protein expressions of Toll like receptor 4 (TLR4), myeloid differentiating factor 88 (MyD88), IL-1R-associated kinases I (IRAK1), IRAK4, inhibitor of nuclear factor kappa-B kinase (IKK)alpha, p-IKK alpha, IKK beta, p-IKK beta, inhibitor of NF-kappa B (I kappa B alpha), p-I kappa B alpha and NF-kappa B in lung tissues were assessed. Besides, we detected the IL-6, IL-1 beta, IL-8, TNF-alpha levels and TLR4, MyD88, NF-kappa B protein expressions in LPS-induced BEAS-2B cells. Consequently, PD significantly inhibited the levels of W/D, MPO, neutrophils number, TNF-alpha, IL-6, IL-113 and reversed TLR4-MyD88-NF-kappa B signaling pathway in lung tissues. In vitro assays, PD effectively negatively mediated the inflammatory cytokines and ameliorated the high expressions of TLR4, MyD88, NF-kappa B caused by LPS simulation in Human bronchial epithelial BEAS-2B cells. This study indicated that PD played a protective role in LPS-induced ALI and BEAS-2B cells. The results supported further study of PD as potential candidate for acute lung injury. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Jiang, Qi; Wang, Ciman; Wang, Huimin; Ji, Hui; Chen, Tong] China Pharmaceut Univ, Sch Pharm, Nanjing 210009, Peoples R China.
   [Yi, Min] Sichuan Univ, West China Hosp, Dept Orthoped Surg, Chengdu 610041, Peoples R China.
   [Guo, Qianqian; Liu, Chao; Ji, Hui; Chen, Tong] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Peoples R China.
   [Meng, Shanshan] Jilin Univ, Hosp 2, Dept Resp Med, Changchun 130041, Peoples R China.
   [Fu, Yeliu] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Yiwu 322000, Peoples R China.
C3 China Pharmaceutical University; Sichuan University; China
   Pharmaceutical University; Jilin University; Zhejiang University
RP Ji, H (corresponding author), China Pharmaceut Univ, Sch Pharm, 24 Tongjiaxiang, Nanjing 210009, Peoples R China.
EM huijicpu@163.com; tongchencpu@163.com
RI /G-4375-2014
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   Zhu LP, 2015, INFLAMMATION, V38, P1589, DOI 10.1007/s10753-015-0134-0
NR 38
TC 183
Z9 200
U1 3
U2 151
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD DEC
PY 2015
VL 29
IS 2
BP 370
EP 376
DI 10.1016/j.intimp.2015.10.027
PG 7
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA CY9ZL
UT WOS:000366764800017
PM 26507165
DA 2026-05-27
ER

PT J
AU Zhang, HY
   Wang, QY
   Wang, JA
   Zhang, SC
   Jia, WW
   He, N
   Xia, XY
   Wang, T
   Lai, LY
   Li, JY
   Du, J
   Olajide, O
   Chen, XM
   Yang, JL
   Li, C
AF Zhang, Haiyan
   Wang, Qiuyue
   Wang, Jianan
   Zhang, Sichao
   Jia, Weiwei
   He, Ning
   Xia, Xiaoyan
   Wang, Ting
   Lai, Liyu
   Li, Jiaying
   Du, Jing
   Olajide, Olaleye
   Chen, Xiangmei
   Yang, Junling
   Li, Chuan
TI Composition analysis of Compound Shenhua Tablet, a seven-herb Chinese
   medicine for IgA nephropathy: evaluation of analyte-capacity of the
   assays
SO CHINESE JOURNAL OF NATURAL MEDICINES
LA English
DT Article
DE Compound Shenhua Tablet; Composition analysis; Analyte-capacity
ID XUEBIJING INJECTION; RADIX ASTRAGALI; GALLIC ACID; DISPOSITION; RATS;
   PHARMACOKINETICS; CATECHOLS
AB Compound Shenhua Tablet, a medicine comprising seven herbs, is employed in treating IgA nephropathy. This study aimed to meticulously analyze its chemical composition. Based on a list of candidate compounds, identified through extensive literature review pertinent to the tablet's herbal components, the composition analysis entailed the systematic identification, characterization, and quantification of the constituents. The analyte-capacity of LC/ESI-MS-based and GC/EI-MS-based assays was evaluated. The identified and characterized constituents were quantified to determine their content levels and were ranked based on the constituents' daily doses. A total of 283 constituents, classified into 12 distinct categories, were identified and characterized in the Compound Shenhua Tablet. These constituents exhibited content levels of 1-10 982 mu g center dot g-1, with daily doses of 0.01-395 mu mol center dot d-1. The predominant constituents, with daily doses of >= 10 mu mol center dot d-1, include nine organic acids (citric acid, quinic acid, chlorogenic acid, cryptochlorogenic acid, gallic acid, neochlorogenic acid, isochlorogenic acid C, isochlorogenic acid B, and linoleic acid), five iridoids (specnuezhenide, nuezhenoside G13, nuezhenidic acid, secoxyloganin, and secologanoside), two monoterpene glycosides (paeoniflorin and albiflorin), a sesquiterpenoid (curzerenone), a triterpenoid (oleanolic acid), and a phenylethanoid (salidroside). Additionally, there were 83, 126, and 55 constituents detected in the medicine with daily doses of 1-10, 0.1-1, and 0.01-0.1 mu mol center dot d-1, respectively. The combination of the LC/ESI-MS-based and GC/EI-MS-based assays demonstrated a complementary relationship in their analyte-capacity for detecting the constituents present in the medicine. This comprehensive composition analysis establishes a solid foundation for further pharmacological research on Compound Shenhua Tablet and facilitates the quality evaluation of this complex herbal medicine.
C1 [Zhang, Haiyan; Wang, Qiuyue; Zhang, Sichao; Yang, Junling; Li, Chuan] Tianjin Univ Tradit Chinese Med, Grad Sch, Tianjin 301617, Peoples R China.
   [Wang, Qiuyue; Wang, Jianan; Zhang, Sichao; Jia, Weiwei; He, Ning; Xia, Xiaoyan; Wang, Ting; Lai, Liyu; Li, Jiaying; Du, Jing; Olajide, Olaleye; Yang, Junling; Li, Chuan] Shanghai Inst Mat Med, Chinese Acad Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China.
   [Wang, Jianan; Lai, Liyu; Yang, Junling; Li, Chuan] Univ Chinese Acad Sci, Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China.
   [Chen, Xiangmei] Chinese Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Kidney Dis, Natl Key Lab Kidney Dis, Beijing Key Lab Kidney Dis Res,Dept Nephrol,Med Ct, Beijing 100853, Peoples R China.
   [Li, Chuan] Zhongshan Inst Drug Discovery, Zhongshan 528400, Peoples R China.
   [Li, Chuan] Haihe Lab Modern Chinese Med, Tianjin 301617, Peoples R China.
C3 Tianjin University of Traditional Chinese Medicine; Chinese Academy of
   Sciences; Shanghai Institute of Materia Medica, CAS; Chinese Academy of
   Sciences; University of Chinese Academy of Sciences, CAS; Chinese
   People's Liberation Army General Hospital
RP Yang, JL; Li, C (corresponding author), Tianjin Univ Tradit Chinese Med, Grad Sch, Tianjin 301617, Peoples R China.; Yang, JL; Li, C (corresponding author), Shanghai Inst Mat Med, Chinese Acad Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China.; Yang, JL; Li, C (corresponding author), Univ Chinese Acad Sci, Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China.; Chen, XM (corresponding author), Chinese Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Kidney Dis, Natl Key Lab Kidney Dis, Beijing Key Lab Kidney Dis Res,Dept Nephrol,Med Ct, Beijing 100853, Peoples R China.; Li, C (corresponding author), Zhongshan Inst Drug Discovery, Zhongshan 528400, Peoples R China.; Li, C (corresponding author), Haihe Lab Modern Chinese Med, Tianjin 301617, Peoples R China.
EM xmchen301@126.com; yangjl@simm.ac.cn; chli@simm.ac.cn
RI 张, 思超/KBD-0469-2024; Zhang, Haiyan/IUN-2627-2023; Jia,
   Weiwei/M-3304-2018
OI Xia, Xiaoyan/0009-0009-3769-2032; Jia, Weiwei/0000-0002-5582-263X
FU National Natur-al Science Foundation of China [82192912, 82074273];
   Innovation Team and Talents Cultivation Program of National
   Ad-ministration of Traditional Chinese Medicine [ZYYCXTD-C-202009];
   Program of State Key Laboratory of Drug Research [SIMM2103ZZ-06]
FX [Research funding] This work was supported by the National Natur-al
   Science Foundation of China (Nos. 82192912 and 82074273) , the
   Innovation Team and Talents Cultivation Program of National
   Ad-ministration of Traditional Chinese Medicine (No. ZYYCXTD-C-202009) ,
   and the Program of State Key Laboratory of Drug Research (No.
   SIMM2103ZZ-06) .
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TC 9
Z9 11
U1 1
U2 24
PU CHINESE JOURNAL NATURAL MEDICINES
PI NANJING
PA 24, TONGJIA XIANG, NANJING, 210009, PEOPLES R CHINA
SN 2095-6975
EI 1875-5364
J9 CHIN J NAT MEDICINES
JI Chin. J. Nat. Med.
PD FEB
PY 2024
VL 22
IS 2
BP 178
EP 192
DI 10.1016/S1875-5364(24)60553-4
EA FEB 2024
PG 15
WC Integrative & Complementary Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; Pharmacology & Pharmacy
GA LP7Z7
UT WOS:001188084400001
PM 38342570
DA 2026-05-27
ER

PT J
AU Liu, J
   Liu, ZY
   Wang, LL
   He, H
   Mu, HL
   Sun, WJ
   Zhou, Y
   Liu, YQ
   Ma, WR
   Zhang, WM
   Fu, MZ
   Fan, YP
   Song, XP
AF Liu, Jia
   Liu, Zengyuan
   Wang, Lili
   He, Hao
   Mu, Hailong
   Sun, Wenjing
   Zhou, Yu
   Liu, Yingqiu
   Ma, Wuren
   Zhang, Weimin
   Fu, Mingzhe
   Fan, Yunpeng
   Song, Xiaoping
TI Bioactivity-guided isolation of immunomodulatory compounds from the
   fruits of Ligustrum lucidum
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Ligustrum lucidum; Macrophage; Lymphocyte; Hydroxytyrosol; NF-kappa B
ID TRADITIONAL CHINESE MEDICINE; NEGATIVE T-CELLS; OLIVE OIL;
   HYDROXYTYROSOL; EXTRACT; PROLIFERATION; ACTIVATION; HEALTH; L.
AB Ethnopharmacological relevance: The fruits of Ligustrum lucidum (FLL) W.T. Aiton (Oleaceae) is included in the 2020 "Chinese Pharmacopoeia" and is widely used in traditional Chinese medicine as a tonic. In recent years, FLL has been reported to improve immune function, but the bioactive compounds and mechanisms of FLL remain poorly characterized.
   Aim of the study: To identify FFL compounds with strong immune activity and explore their molecular mechanisms.
   Materials and methods: The phagocytic activity of RAW264.7 macrophages and proliferation activity of spleen lymphocytes were used to guide the isolation of bioactive compounds from FLL extracts. Lymphocyte subpopulations, Ca2+ concentrations, and surface molecule expression were analyzed using flow cytometry. Cytokine secretion was examined using ELISA. FITC-OVA uptake was observed using fluorescence microscopy. NF-kappa B activation was analyzed using western blotting.
   Results: The extraction and isolation produced ten compounds, namely oleuropeinic acid, nuezhenide, isonuezhenide, salidroside, isoligustrosidic acid, ligulucidumosides A, 8(E)-nuezhenide, hydroxytyrosol, oleuropein, and p-hydroxyphenethyl 7-beta-D-glucosideelenolic acid ester were isolated and identified from FLL-Bu-30%. Immunoactivity experiments showed that hydroxytyrosol had the strongest macrophage phagocytotic and lymphocyte proliferation-promoting activities. Further studies showed that hydroxytyrosol could significantly enhance lymphocyte subsets CD3+, CD4(+)/CD8(+), and CD3(+)CD4(-)CD8(-), promote IL-4, IFN-gamma, and TNF-alpha secretion, and increase intracellular Ca2+ concentrations. In addition, the results from RAW264.7 macrophages showed that hydroxytyrosol increased FITC-OVA uptake, induced TNF-alpha and IL-1 beta production, upregulated MHC-II, CD80, and CD86 expression, promoted cytoplasmic I kappa B-alpha degradation, and increased nuclear NF-kappa B p65 levels.
   Conclusion: Our study provides substantial evidence regarding the mechanism of the immunomodulatory effects of compounds from FLL.
C1 [Liu, Jia; Liu, Zengyuan; Wang, Lili; He, Hao; Mu, Hailong; Sun, Wenjing; Zhou, Yu; Liu, Yingqiu; Ma, Wuren; Zhang, Weimin; Fu, Mingzhe; Fan, Yunpeng; Song, Xiaoping] Northwest A&F Univ, Coll Vet Med, Yangling 712100, Shaanxi, Peoples R China.
C3 Northwest A&F University - China
RP Fan, YP; Song, XP (corresponding author), Northwest A&F Univ, Coll Vet Med, Yangling 712100, Shaanxi, Peoples R China.
EM ypfan@nwsuaf.edu.cn; sxptcvm@163.com
RI Sun, Sun Wenjing/HLH-7748-2023; liu, yingqiu/HDN-6600-2022
OI liu, yingqiu/0000-0001-5272-1377
FU Special Fund for Basic Research of the Ministry of Science and
   Technology, China [2013FY110600]
FX This research was supported by the Special Fund for Basic Research of
   the Ministry of Science and Technology, China (grant number
   2013FY110600). We are grateful to the staff at the Institute of TCVM of
   Northwest A&F University for their experimental assistance.
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U1 2
U2 34
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
EI 1872-7573
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD JUN 28
PY 2021
VL 274
AR 114079
DI 10.1016/j.jep.2021.114079
EA APR 2021
PG 14
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA RX9YT
UT WOS:000647572800005
PM 33798661
DA 2026-05-27
ER

PT J
AU Liu, QZ
   Shi, YN
   Qin, L
AF Liu, Qizhi
   Shi, Yaning
   Qin, Li
TI Targeting pyroptosis in atherosclerosis: emerging pharmacologic
   strategies and natural compound-based therapeutics-a narrative review
SO INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
LA English
DT Review
DE Atherosclerosis; Gasdermin D; Inflammasome; Natural compounds;
   Pharmacologic therapy; Pyroptosis
ID ENDOTHELIAL-CELL PYROPTOSIS; NLRP3 INFLAMMASOME; GASDERMIN D; PATHWAY;
   PATHOGENESIS; ACTIVATION; CASPASES; CLEAVAGE; DEATH
AB IntroductionAtherosclerosis is the pathological foundation of most cardiovascular diseases and remains the leading cause of mortality worldwide. Increasing evidence shows that pyroptosis, a pro-inflammatory form of programmed cell death mediated by inflammasome activation and gasdermin D (GSDMD)-mediated pore formation, plays a key role in vascular endothelial dysfunction, immune cell activation, and plaque destabilization. Understanding how pharmacological agents modulate pyroptotic signaling is crucial for identifying new therapeutic strategies for atherosclerosis prevention and treatment.AimThis narrative review aims to summarize the current evidence on the mechanisms by which pyroptosis contributes to the initiation and progression of atherosclerosis and to explore pharmacological strategies, including natural and synthetic compounds that target pyroptotic pathways to exert anti-atherosclerotic effects.MethodA narrative literature review was conducted using PubMed, Web of Science, and Scopus, from database inception to September 2025. The search combined terms related to "pyroptosis," "atherosclerosis," "inflammasome," "gasdermin," "drug," and "natural compound." Studies reporting the mechanisms or pharmacologic modulation of pyroptosis in endothelial cells, macrophages, or vascular smooth muscle cells were included, and data were synthesized according to cell type and mechanism of drug action.ResultsPyroptosis contributes to all the stages of atherosclerosis by promoting vascular inflammation, lipid accumulation, and plaque rupture. The NLRP3 inflammasome, caspase-1, and GSDMD are major pharmacological targets. Small-molecule inhibitors, such as MCC950 and VX-765, suppress inflammasome activation and cytokine release, thereby reducing plaque burden. Multiple natural compounds, including salidroside, salvianolic acids, puerarin, oxymatrine, and quercetin, exert protective effects through antioxidative and anti-inflammatory mechanisms that inhibit inflammasome activation and restore endothelial integrity. These findings suggest the feasibility of combining pyroptosis-targeting compounds with established antiatherosclerotic therapies.ConclusionTargeting pyroptosis offers a promising pharmacological approach for mitigating vascular inflammation and stabilizing atherosclerotic plaques. Natural compounds with inflammasome-modulating activities serve as valuable chemical scaffolds for the development of novel therapeutics. Further pharmacokinetic, toxicological, and clinical studies are needed to translate these mechanistic insights into effective treatment strategies for patients with atherosclerotic cardiovascular disease.
C1 [Liu, Qizhi] Hunan Univ Chinese Med, Sch Tradit Chinese Med, Changsha 410208, Hunan, Peoples R China.
   [Shi, Yaning; Qin, Li] Hunan Univ Chinese Med, Acad Chinese Med Sci, Lab Stem Cell Regulat Chinese Med & Its Applicat, Changsha 410208, Hunan, Peoples R China.
   [Qin, Li] Hunan Univ Chinese Med, Inst Key Lab Vasc Biol & Translat Med Hunan Prov, Changsha 410208, Hunan, Peoples R China.
C3 Hunan University of Chinese Medicine; Hunan University of Chinese
   Medicine; Hunan University of Chinese Medicine
RP Qin, L (corresponding author), Hunan Univ Chinese Med, Acad Chinese Med Sci, Lab Stem Cell Regulat Chinese Med & Its Applicat, Changsha 410208, Hunan, Peoples R China.; Qin, L (corresponding author), Hunan Univ Chinese Med, Inst Key Lab Vasc Biol & Translat Med Hunan Prov, Changsha 410208, Hunan, Peoples R China.
EM lqin@hnucm.edu.cn
FU Open Fund Project of National Key Laboratory Cultivation Base of Chinese
   Medicinal Powder & Innovative Medicinal Jointly Established by Province
   and Ministry [23PTKF1016]; Academician Liu Liang Workstation Guidance
   Project [24YS002]; Natural Science Foundation of Hunan Province
   [2023JJ40485]; First-Class Discipline of Pharmaceutical Science of Hunan
   Province; the National Natural Sciences Foundation of China [82274159,
   82474133, 82505074]
FX This work was supported by the National Natural Sciences Foundation of
   China (82274159, 82474133, 82505074), Cross-disciplinary Research
   Project of Hunan University of Chinese Medicine (2025JC0203),
   Academician Liu Liang Workstation Guidance Project (24YS002), Natural
   Science Foundation of Hunan Province (2023JJ40485), Open Fund Project of
   National Key Laboratory Cultivation Base of Chinese Medicinal Powder &
   Innovative Medicinal Jointly Established by Province and Ministry
   (23PTKF1016), and First-Class Discipline of Pharmaceutical Science of
   Hunan Province.
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NR 97
TC 1
Z9 1
U1 10
U2 10
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 2210-7703
EI 2210-7711
J9 INT J CLIN PHARM-NET
JI Int. J. Clin. Phar,.
PD FEB
PY 2026
VL 48
IS 1
BP 67
EP 79
DI 10.1007/s11096-025-02065-0
EA DEC 2025
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DC2GA
UT WOS:001634599700001
PM 41369784
DA 2026-05-27
ER

PT J
AU Chen, TF
   Li, SH
   Lian, DY
   Hu, Q
   Hou, HP
   Niu, DL
   Li, H
   Song, L
   Gao, YH
   Chen, Y
   Hu, XR
   Li, JR
   Ye, ZG
   Peng, B
   Zhang, GP
AF Chen, Tengfei
   Li, Sihan
   Lian, Dongyin
   Hu, Qin
   Hou, Hongping
   Niu, Delian
   Li, Han
   Song, Ling
   Gao, Yunhang
   Chen, Ying
   Hu, Xiaoru
   Li, Jianrong
   Ye, Zuguang
   Peng, Bo
   Zhang, Guangping
TI Integrated Network Pharmacology and Experimental Approach to Investigate
   the Protective Effect of Jin Gu Lian Capsule on Rheumatoid Arthritis by
   Inhibiting Inflammation via IL-17/NF-κB Pathway
SO DRUG DESIGN DEVELOPMENT AND THERAPY
LA English
DT Article
DE rheumatoid arthritis; Jin Gu Lian capsules; network pharmacology;
   experimental validation; immune-mediated inflammation
ID MECHANISMS; COLLAGEN
AB Purpose: This study aimed to investigate the main pharmacological action and underlying mechanisms of Jin Gu Lian Capsule (JGL) against rheumatoid arthritis (RA) based on network pharmacology and experimental verification.Methods: Network pharmacology approaches were performed to explore the core active compounds of JGL, key therapeutic targets, and signaling pathways. Molecular docking was used to predict the binding affinity of compounds with targets. In vivo experiments were undertaken to validate the findings from network analysis.Results: A total of 52 targets were identified as candidate JGL targets for RA. Sixteen ingredients were identified as the core active compounds, including, quercetin, myricetin, salidroside, etc. Interleukin-1 beta (IL1B), transcription factor AP-1 (JUN), growth-regulated alpha protein (CXCL1), C-X-C motif chemokine (CXCL)3, CXCL2, signal transducer and activator of transcription 1 (STAT1), prostaglandin G/H synthase 2 (PTGS2), matrix metalloproteinase (MMP)1, inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB) and transcription factor p65 (RELA) were obtained as the key therapeutic targets. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis showed that the efficacy of JGL was functionally involved in regulating immune-mediated inflammation, in which IL-17/NF-kappa B signaling was recommended as one of the main pathways. Molecular docking suggested that the core active compounds bound strongly to their respective targets. Experimentally, JGL treatment mitigated inflammation, showed analgesic activity, and ameliorated collagen-induced arthritis. Enzyme-linked immunosorbent assay showed that JGL effectively reduced the serum levels of cytokines, chemokines, and MMPs. Immunohistochemistry staining showed that JGL markedly reduced the expression of the targets in IL-17/NF-kappa B pathway including IL-17A, IL-17RA, NF-kappa B p65, C-X-C motif ligand 2, MMP1 and MMP13. Conclusion: This investigation provided evidence that JGL may alleviate RA symptoms by partially inhibiting the immune-mediated inflammation via IL-17/NF-kappa B pathway.
C1 [Chen, Tengfei; Li, Sihan; Lian, Dongyin; Hou, Hongping; Niu, Delian; Li, Han; Song, Ling; Gao, Yunhang; Chen, Ying; Li, Jianrong; Ye, Zuguang; Peng, Bo; Zhang, Guangping] China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing, Peoples R China.
   [Hu, Qin] Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing, Peoples R China.
   [Hu, Xiaoru] Natl Inst Food & Drug Control, Beijing, Peoples R China.
C3 China Academy of Chinese Medical Sciences; Institute of Chinese Materia
   Medica, CACMS; Beijing University of Technology; National Institute of
   Food & Drug Control - China
RP Peng, B; Zhang, GP (corresponding author), China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing, Peoples R China.
EM bpeng@icmm.ac.cn; gpzhang@icmm.ac.cn
RI Li, Jian-Rong/G-2781-2010; hu, xiaoru/LIH-0577-2024
FU National Key R&D Program of China [2018YFC1708105]; Scientific and
   Technological Innovation Project of the China Academy of Chinese Medical
   Sciences [CI2021A04615, CI2021A04905]
FX Funding This study was supported by the National Key R&D Program of
   China (2018YFC1708105) and the Scientific and Technological Innovation
   Project of the China Academy of Chinese Medical Sciences (CI2021A04615
   and CI2021A04905) .
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NR 68
TC 17
Z9 21
U1 1
U2 16
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1177-8881
J9 DRUG DES DEV THER
JI Drug Des. Dev. Ther.
PY 2023
VL 17
BP 3723
EP 3748
DI 10.2147/DDDT.S423022
PG 26
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CK1I6
UT WOS:001125051300001
PM 38107658
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Rattan, S
   Kumar, D
   Warghat, AR
AF Rattan, Shiv
   Kumar, Dinesh
   Warghat, Ashish R.
TI The influence of phenylalanine feeding on cell growth, antioxidant
   activity, phenylpropanoids content, and yield in cell suspension culture
   of Rhodiola imbricata (Edgew.)
SO PLANT CELL TISSUE AND ORGAN CULTURE
LA English
DT Article
DE Cell suspension culture; Phenylpropanoids; Precursor feeding; Metabolite
   yield; Cell growth; Rhodiola imbricata
ID COMPACT CALLUS AGGREGATE; IN-VITRO PROPAGATION; SALIDROSIDE PRODUCTION;
   SECONDARY METABOLISM; ROSEA L.; BIOTRANSFORMATION; SACHALINENSIS;
   STRATEGIES; REGULATORS; GLYCOSIDES
AB Key message The present investigation demonstrates the effect of phenylalanine precursor feeding; 0.5 mM, 1 mM, 2 mM, and 3 mM on cell growth, physiological characteristics, antioxidant activity, and metabolite yield for the first time in cell suspension culture derived from friable leaf callus of Rhodiola imbricata.
   Precursor feeding is a well-known strategy to enhance the commercial production of bioactive compounds in plant cell culture systems. For the first time, an effective in vitro platform was established for the enhanced production of phenylpropanoids with a precursor feeding approach in the cell suspension culture derived from friable leaf callus of Rhodiola imbricata. Precursor, phenylalanine feeding of 0.5 mM, 1 mM, 2 mM, and 3 mM concentrations were added to the cell suspension of R. imbricata and further, it was evaluated for the cell growth and production of phenylpropanoids (rosavin, rosarin, and p-coumaric acid). The suspension culture showed maximum cell growth (FW; 117 g/L, DW; 5.73 g/L) on day 15 of the incubation period in precursor untreated cells. Furthermore, cell suspension cultures treated with 1 mM phenylalanine accumulated the maximum biomass (FW; 136 g/L, DW; 6.70 g/L) on day 15. The enhanced rosavin (1.57 mg/g DW) and rosarin (0.78 mg/g DW) content were achieved on day 12 in 1 mM precursor concentration. Similarly, p-coumaric acid was detected maximum (2.50 mg/g DW) on day 12 in 3 mM precursor-treated suspension cultures of R. imbricata. The total phenolic content was improved significantly (43.72 mg/g DW) on day 12 in 2 mM phenylalanine treatment. Whereas, total flavonoid content was observed maximum (24.50 mg/g DW) on day 12 with 2 mM precursor concentration. The present work concluded that the precursor-mediated approach enhanced the overall phenylpropanoids production in the cell suspension culture of R. imbricata.
C1 [Rattan, Shiv; Warghat, Ashish R.] CSIR Inst Himalayan Bioresource Technol, Biotechnol Div, Palampur 176061, Himachal Prades, India.
   [Rattan, Shiv; Kumar, Dinesh; Warghat, Ashish R.] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India.
   [Kumar, Dinesh] CSIR Inst Himalayan Bioresource Technol, Chem Technol Div, Palampur 176061, Himachal Prades, India.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   Institute of Himalayan Bioresource Technology (IHBT); Academy of
   Scientific & Innovative Research (AcSIR); Council of Scientific &
   Industrial Research (CSIR) - India; CSIR - Institute of Himalayan
   Bioresource Technology (IHBT)
RP Warghat, AR (corresponding author), CSIR Inst Himalayan Bioresource Technol, Biotechnol Div, Palampur 176061, Himachal Prades, India.; Warghat, AR (corresponding author), Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India.
EM shivrattan.negi@gmail.com; dineshkumar@ihbt.res.in;
   ashishwarghat@hotmail.com
RI ; Kumar, Dinesh/F-5081-2015; Warghat, Ashish/AAS-6726-2020
OI negi, Shivrattan/0000-0002-3896-0811; Kumar, Dinesh/0000-0003-4123-0235;
   Warghat, Ashish/0000-0001-5867-3329
FU Council of Scientific and Industrial Research (CSIR), Government of
   India [MLP-0201]; National Medicinal Plants Board (NMPB), Government of
   India [GAP-0274]
FX The authors acknowledge the Council of Scientific and Industrial
   Research (CSIR), Government of India, under the project
   "Biotechnological interventions for sustainable bio-economy generation
   through characterization, conservation, prospection and utilization of
   Himalayan bioresources" (MLP-0201) and National Medicinal Plants Board
   (NMPB), Government of India, under the project "Development of
   Probiotics for Plant Tissue Culture Boosting the performance of micro
   propagated plant materials by supplementing plant-associated useful
   endophytes" (GAP-0274) for providing financial support. CSIRIHBT
   publication no. is 5068.
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NR 43
TC 12
Z9 13
U1 3
U2 23
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0167-6857
EI 1573-5044
J9 PLANT CELL TISS ORG
JI Plant Cell Tissue Organ Cult.
PD NOV
PY 2022
VL 151
IS 2
BP 347
EP 359
DI 10.1007/s11240-022-02356-8
EA AUG 2022
PG 13
WC Biotechnology & Applied Microbiology; Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Plant Sciences
GA 5Q6UB
UT WOS:000840065000002
DA 2026-05-27
ER

PT J
AU Zhang, X
   Du, QM
   Yang, Y
   Wang, JN
   Dou, S
   Liu, C
   Duan, JG
AF Zhang, Xu
   Du, Qianming
   Yang, Yan
   Wang, Jianing
   Dou, Shuai
   Liu, Chao
   Duan, Junguo
TI The protective effect of Luteolin on myocardial ischemia/reperfusion
   (I/R) injury through TLR4/NF-κB/NLRP3 inflammasome pathway
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Luteolin; Myocardial ischemia reperfusion injury; TLR4/NF-kappa B; NLRP3
   inflammasome
ID ISCHEMIA-REPERFUSION INJURY; NLRP3 INFLAMMASOME; RATS; SALIDROSIDE;
   MACROPHAGES; ACTIVATION; PROTEIN
AB The purpose of the present study was to investigate the effect of Luteolin(Lut) on myocardial ischemia reperfusion injury and explore the underlying mechanism. Myocardial ischemia reperfusion injury (I/R) model was induced with 30 min of left anterior descending (LAD) occlusion followed by 24 h of reperfusion. In vivo, the rats were randomly divided into 5 groups: (1) Sham, (2) I/R, (3) I/R + Lut(40 mg/kg), (4) I/R + Lut(80 mg/kg) and (5) I/R + Lut(160 mg/kg). In vitro, the H9c2 cells were assigned to five groups: (1) control, (2) hypoxia-reoxygenation(H/R), (3) H/R + Lut(5 mu M), (4) H/R + Lut(10 mu M) and (5) H/R + Lut (20 mM). The H9c2 cells were stimulated with H/R protocol in the presence or absence of TAK-242, a TLR4 inhibitor. As a result, Lut ameliorated myocardial ischemia reperfusion injury and hypoxia-reoxygenation as evidenced by triphenyl tetrazolium chloride (TTC) staining and MTT assay, respectively. Lut was founded to decrease the levels of aspartate transaminase(AST), creatine phosphokinase-isoenzyme (CKMB) and lactate dehydrogenase (LDH) in serum. Moreover, Lut could reduce the contents of interleukin1 beta(IL-1 beta), interleukin-18 (IL-18) and tumor necrosis factor-alpha (TNF-alpha) in serum of rats and supernant of H9c2 cells. In addition, Lut remarkably downregulated the expressions of toll-like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88) and nuclear factor kappa B (NF-kB). Lut also inhibited the upregulations of inflammasome components, such as NOD-like receptor 3(NLRP3), apoptosis-associated speck-like protein containing CARD(ASC) in I/R-induced rats and H/R-induced H9c2 cells. In conclusion, Lut exhibited strong favorable cardioprotective effect on myocardial I/R injury which might be related to the down-regulation of the TLR4-meidated NF-kB/NLRP3 inflammasome in vivo and in vitro. (C) 2017 Published by Elsevier Masson SAS.
C1 [Zhang, Xu] Chengdu Univ TCM, Clin Med Coll, Chengdu 610075, Sichuan, Peoples R China.
   [Du, Qianming] China Pharmaceut Univ, Nanjing Hosp 1, Gen Clin Res Ctr, Nanjing, Jiangsu, Peoples R China.
   [Yang, Yan] Third Peoples Hosp Chengdu, Dept Tradit Chinese Med, 82 Qing Long St, Chengdu 610031, Sichuan, Peoples R China.
   [Wang, Jianing] China Pharmaceut Univ, Neurobiol Lab, Jiangsu Ctr Drug Screening, Nanjing 210009, Jiangsu, Peoples R China.
   [Dou, Shuai; Duan, Junguo] Chengdu Univ TCM, Dept Ophthalmol, Chengdu 610075, Sichuan, Peoples R China.
   [Zhang, Xu] First Peoples Hosp Chengdu, Chengdu 610075, Sichuan, Peoples R China.
   [Du, Qianming] Nanjing Med Univ, Nanjing Hosp 1, Gen Clin Res Ctr, Nanjing, Jiangsu, Peoples R China.
   [Liu, Chao] China Pharmaceut Univ, Nanjing Hosp 1, Dept Pharmaceut, Nanjing 210000, Jiangsu, Peoples R China.
   [Liu, Chao] Nanjing Med Univ, Nanjing Hosp 1, Dept Pharmaceut, Nanjing, Jiangsu, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; China Pharmaceutical
   University; China Pharmaceutical University; Chengdu University of
   Traditional Chinese Medicine; Nanjing Medical University; China
   Pharmaceutical University; Nanjing Medical University
RP Duan, JG (corresponding author), Chengdu Univ TCM, Dept Ophthalmol, Chengdu 610075, Sichuan, Peoples R China.; Liu, C (corresponding author), China Pharmaceut Univ, Nanjing Hosp 1, Dept Pharmaceut, Nanjing 210000, Jiangsu, Peoples R China.
EM liuchaogermany@sina.cn; duanjgs@126.com
RI wang, jianing/LCE-6869-2024
OI , Qianming Du/0000-0002-1092-2899
FU National Natural Science Foundation of China [81373516]; National
   Science & Technology Pillar Program during the Twelfth Five-year Plan
   Period [2014BAI10]; National key foundation for exploring scientific
   instrument [2013YQ490859]
FX This study was financially supported by the National Natural Science
   Foundation of China (Grant No. 81373516), the National Science &
   Technology Pillar Program during the Twelfth Five-year Plan Period
   (Grant No. 2014BAI10) and the National key foundation for exploring
   scientific instrument (Grant No. 2013YQ490859).
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NR 23
TC 146
Z9 163
U1 1
U2 72
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD JUL
PY 2017
VL 91
BP 1042
EP 1052
DI 10.1016/j.biopha.2017.05.033
PG 11
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA FB8PB
UT WOS:000406399900114
PM 28525945
DA 2026-05-27
ER

PT J
AU Dolker, D
   Behera, S
   Justine, AK
   Kumari, V
   Pati, PK
AF Dolker, Dechen
   Behera, Shashikanta
   Justine, Angima Kibari
   Kumari, Vaishali
   Pati, Pratap Kumar
TI Production of large-scale genetically identical and phytochemically
   stable in vitro plants of Rhodiola imbricata using
   meta-Topolin and liquid culture system
SO PLANT CELL TISSUE AND ORGAN CULTURE
LA English
DT Article
DE Genetic fidelity; HPLC; Liquid culture; Meta-Topolin; Micropropagation;
   Rhodiola imbricata; Secondary metabolite
ID CORONARIUM J. KOENIG; BIOCHEMICAL FIDELITY; AQUEOUS EXTRACT; CLONAL
   FIDELITY; STABILITY; ROOT; MICROPROPAGATION; MULTIPLICATION;
   PROLIFERATION; BENZYLADENINE
AB Rhodiola imbricata is a rare and endangered plant of the Trans-Himalayan region having important medicinal properties. It holds immense therapeutic value against a wide range of diseases and health problems including hypoxia, cancer, stress, anxiety, fatigue, and gastrointestinal problems. The plant which is normally propagated through seeds suffers from drawbacks such as limited seed availability, low seed viability, and germination, limited geographical distribution, slow growth, and slow accumulation of secondary metabolites. Owing to the growing demand for this plant, a novel, highly efficient liquid culture system using meta-Topolin (mT) was developed for its rapid multiplication and continuous production of important bioactive compounds. A comparative analysis was conducted to evaluate the response of shoot multiplication, rooting, and secondary metabolite content in the solid and liquid culture media. In vitro seedlings were inoculated on Murashige and Skoog's (MS) (1962) medium supplemented with different concentrations of cytokinins. Among the tested cytokinins, the maximum number of shoots were observed in 20 mL of liquid MS medium supplemented with mT (5.0 mu M). While Indole-3-butyric acid (IBA) (10.0 mu M) exhibited the highest rooting response (95%). Mass propagation of microshoots was achieved using a specialized box, resulting in an improved survival rate of 85% during the subsequent hardening process. The secondary metabolite content, including rosavin, salidroside, tyrosol, total polyphenolic content (TPC), and antioxidant properties were estimated for shoots grown in both agar-gelled solid and liquid culture media. Overall, liquid MS medium supplemented with mT (5.0 mu M) was found to be the optimum medium for secondary metabolites production in comparison to solid medium. Further, the genetic and phytochemical stability of the prolong culture of this plant under in vitro conditions were confirmed. This system facilitates large scale production of in vitro plants as well as secondary metabolites throughout the year, which is crucial for various industrial applications.
C1 [Dolker, Dechen; Behera, Shashikanta; Justine, Angima Kibari; Kumari, Vaishali; Pati, Pratap Kumar] Guru Nanak Dev Univ, Dept Biotechnol, Amritsar 143005, Punjab, India.
   [Pati, Pratap Kumar] Guru Nanak Dev Univ, Dept Agr, Amritsar 143005, Punjab, India.
C3 Guru Nanak Dev University; Guru Nanak Dev University
RP Pati, PK (corresponding author), Guru Nanak Dev Univ, Dept Biotechnol, Amritsar 143005, Punjab, India.; Pati, PK (corresponding author), Guru Nanak Dev Univ, Dept Agr, Amritsar 143005, Punjab, India.
EM pkpati@yahoo.com
OI Behera, Shashikanta/0000-0002-6418-1264; Justine, Angima
   Kibari/0000-0002-5859-4708
FU Council of Scientific and Industrial Research (CSIR), Government of
   India; Rashtriya Uchchattar Shiksha Abhiyan (RUSA-II); University Grants
   Commission (UGC) [F.4-2/2006 (BSR)/20-21/0380]; 
   [09/254(0286)/2018-EMR-I]
FX Financial assistance from the Council of Scientific and Industrial
   Research (CSIR), Government of India is duly acknowledged. Authors
   thankfully acknowledge Rashtriya Uchchattar Shiksha Abhiyan (RUSA-II)
   for providing financial support to the Centre for Agricultural Research
   and Innovation (CARI), Guru Nanak Dev University, Amritsar, Punjab. DD
   is grateful to the Council of Scientific and Industrial Research (CSIR),
   Government of India for the award of CSIR-SRF [File No.
   09/254(0286)/2018-EMR-I]. SB is thankful for the fellowship received
   under Dr. D.S. Kothari Post-Doctoral Fellowship (DSKPDF) scheme by the
   University Grants Commission (UGC) [F.4-2/2006 (BSR)/20-21/0380].
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NR 72
TC 10
Z9 12
U1 1
U2 10
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0167-6857
EI 1573-5044
J9 PLANT CELL TISS ORG
JI Plant Cell Tissue Organ Cult.
PD JAN
PY 2024
VL 156
IS 1
AR 18
DI 10.1007/s11240-023-02640-1
PG 17
WC Biotechnology & Applied Microbiology; Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Plant Sciences
GA CO0H4
UT WOS:001126066700005
DA 2026-05-27
ER

PT J
AU James, N
   Owusu, E
   Rivera, G
   Bandyopadhyay, D
AF James, Nneoma
   Owusu, Esther
   Rivera, Gildardo
   Bandyopadhyay, Debasish
TI Small Molecule Therapeutics in the Pipeline Targeting for
   Triple-Negative Breast Cancer: Origin, Challenges, Opportunities, and
   Mechanisms of Action
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE triple-negative breast cancer; breast cancer; estrogen receptor; human
   epidermal growth factor receptor 2; progesterone receptor; small
   molecules; chemotherapy; chemoresistance; immunotherapy; signaling
   pathways
ID PARP INHIBITOR VELIPARIB; DRUG DISCOVERY; NEOADJUVANT CHEMOTHERAPY;
   TUMOR MICROENVIRONMENT; ESTIMATE SOLUBILITY; PLUS CARBOPLATIN;
   RANDOMIZED-TRIAL; VEGFR INHIBITOR; SINGLE-AGENT; CROSS-TALK
AB Triple-negative breast cancer (TNBC) cells are devoid of estrogen receptors (ERs), progesterone receptor (PRs), and human epidermal growth factor receptor 2 (HER2), and it (TNBC) counts for about 10-15% of all breast cancers. TNBC is highly invasive, having a faster growth rate and a higher risk of metastasis and recurrence. Still, chemotherapy is one of the widely used options for treating TNBC. This study reviewed the histological and molecular characterization of TNBC subtypes, signaling pathways that are aberrantly expressed, and small molecules targeting these pathways, as either single agents or in combination with other therapeutic agents like chemotherapeutics, immunotherapeutics, and antibody-drug conjugates; their mechanisms of action, challenges, and future perspectives were also reviewed. A detailed analytical review was carried out using the literature collected from the SciFinder, PubMed, ScienceDirect, Google Scholar, ACS, Springer, and Wiley databases. Several small molecule inhibitors were found to be therapeutics for treating TNBC. The mechanism of action and the different signaling pathways through which the small molecules exert their effects were studied, including clinical trials, if reported. These small molecule inhibitors include buparlisib, everolimus, vandetanib, apatinib, olaparib, salidroside, etc. Some of the signaling pathways involved in TNBC, including the VEGF, PARP, STAT3, MAPK, EGFR, P13K, and SRC pathways, were discussed. Due to the absence of these biomarkers, drug development for treating TNBC is challenging, with chemotherapy being the main therapeutic agent. However, chemotherapy is associated with chemoresistance and a high toxicity to healthy cells as side effects. Hence, there is a continuous demand for small-molecule inhibitors that specifically target several signaling pathways that are abnormally expressed in TNBC. We attempted to include all the recent developments in this field. Any omission is truly unintentional.
C1 [James, Nneoma; Owusu, Esther; Bandyopadhyay, Debasish] Univ Texas Rio Grande Valley, Sch Integrat Biol & Chem Sci, 1201 W Univ Dr, Edinburg, TX 78539 USA.
   [Rivera, Gildardo] Inst Politecn Nacl, Lab Biotecnol Farmaceut, Ctr Biotecnol Gen, Reynosa 88710, Mexico.
   [Bandyopadhyay, Debasish] Univ Texas Rio Grande Valley, Sch Earth Environm & Marine Sci SEEMS, 1201 W Univ Dr, Edinburg, TX 78539 USA.
C3 University of Texas System; University of Texas Rio Grande Valley;
   Instituto Politecnico Nacional - Mexico; University of Texas System;
   University of Texas Rio Grande Valley
RP Bandyopadhyay, D (corresponding author), Univ Texas Rio Grande Valley, Sch Integrat Biol & Chem Sci, 1201 W Univ Dr, Edinburg, TX 78539 USA.; Bandyopadhyay, D (corresponding author), Univ Texas Rio Grande Valley, Sch Earth Environm & Marine Sci SEEMS, 1201 W Univ Dr, Edinburg, TX 78539 USA.
EM nneoma.james01@utrgv.edu; esther.owusu01@utrgv.edu; giriveras@ipn.mx;
   debasish.bandyopadhyay@utrgv.edu
RI ; Rivera, Gildardo/AGF-2021-2022
OI Owusu, Esther/0009-0004-7634-2004; Rivera, Gildardo/0000-0001-9842-4167
FU CPRIT Integrated Cancer Research Core (ICRC); School of Integrative
   Biological and Chemical Sciences
FX We thank the School of Integrative Biological and Chemical Sciences, at
   the University of Texas Rio Grande Valley for providing infrastructural
   support.
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NR 116
TC 12
Z9 18
U1 5
U2 20
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUN
PY 2024
VL 25
IS 11
AR 6285
DI 10.3390/ijms25116285
PG 25
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA UC2I4
UT WOS:001245793300001
PM 38892472
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Bai, X
   Bian, ZG
   Zhang, M
AF Bai, Xue
   Bian, Zhigang
   Zhang, Meng
TI Targeting the Nrf2 signaling pathway using phytochemical ingredients: A
   novel therapeutic road map to combat neurodegenerative diseases
SO PHYTOMEDICINE
LA English
DT Article
DE Nrf2; Nrf2 activators; Phytochemical ingredients; Neurodegenerative
   diseases; Oxidative stress
ID INDUCED OXIDATIVE STRESS; PARKINSONS-DISEASE; ELLAGIC ACID; MOUSE MODEL;
   FUNCTIONAL-CHARACTERIZATION; INDUCED NEUROTOXICITY; ALZHEIMERS-DISEASE;
   TANSHINONE I; BRAIN-INJURY; RAT MODEL
AB Background: Nuclear factor erythroid 2-related factor 2 (Nrf2) is a classical nuclear transcription factor that reg-ulates the system's anti-oxidative stress response. The activation of Nrf2 induces the expression of antioxidant proteins and improves the system's anti-oxidative stress ability. Accumulating evidence suggests that Nrf2-centered signaling pathways may be a key pharmacological target for the treatment of neurodegenerative dis-eases (NDDs). However, phytochemicals as new therapeutic agents against NDDs have not been clearly delineated.
   Purpose: To review the therapeutic effects of phytochemical ingredients on NDDs by activating Nrf2 and reducing oxidative stress injury.
   Methods: A comprehensive search of published articles was performed using various literature databases including PubMed, Google Scholar, and China National Knowledge Infrastructure. The search terms included "Nrf2", "phytochemical ingredients", "natural bioactive agents", "neurodegenerative diseases", "Antioxidant", "Alzheimer's disease", "Parkinson's disease", "Huntington's disease", "amyotrophic lateral sclerosis" "multiple sclerosis", "toxicity", and combinations of these keywords. A total of 769 preclinical studies were retrieved until August 2022, and we included 39 of these articless on phytochemistry, pharmacology, toxicology and other fields.
   Results: Numerous in vivo and in vitro studies showed that phytochemical ingredients could act as an Nrf2 acti-vator in the treatment of NDDs through the antioxidant defense mechanism. These phytochemical ingredients, such as salidroside, naringenin, resveratrol, sesaminol, ellagic acid, ginsenoside Re, tanshinone I, sulforaphane, curcumin, naringin, tetramethylpyrazine, withametelin, magnolol, piperine, and myricetin, had the potential to improve Nrf2 signaling, thereby combatting NDDs.
   Conclusion: As Nrf2 activators, phytochemical ingredients may provide a novel potential strategy for the treatment of NDDs. Here, we reviewed the interaction between phytochemical ingredients, Nrf2, and its antioxidant damaging pathway in NDDs and explored the advantages of phytochemical ingredients in anti-oxidative stress, which provides a reliable basis for improving the treatment of NDDs. However, further clinical trials are needed to determine the safety and efficacy of Nrf2 activators for NDDs.
C1 [Bai, Xue; Zhang, Meng] China Med Univ, Shengjing Hosp, Dept Gerontol & Geriatr, 36 Sanhao St, Shenyang 110004, Liaoning, Peoples R China.
   [Bian, Zhigang] China Med Univ, Shengjing Hosp, Dept Otolaryngol Head & Neck Surg, 36 Sanhao St, Shenyang 110004, Liaoning, Peoples R China.
C3 China Medical University; China Medical University
RP Zhang, M (corresponding author), China Med Univ, Shengjing Hosp, Dept Gerontol & Geriatr, 36 Sanhao St, Shenyang 110004, Liaoning, Peoples R China.
EM zhangm0810@163.com
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NR 197
TC 39
Z9 49
U1 0
U2 33
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD JAN
PY 2023
VL 109
AR 154582
DI 10.1016/j.phymed.2022.154582
EA JAN 2023
PG 18
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA 8K9EL
UT WOS:000923396100001
PM 36610130
DA 2026-05-27
ER

PT J
AU Yang, XY
   Dong, X
   Li, JJ
   Zhen, AP
   Shi, WH
   Shen, CF
   Liu, JW
AF Yang, Xinyue
   Dong, Xiang
   Li, Jiajia
   Zhen, Aiping
   Shi, Wenhui
   Shen, Caifu
   Liu, Jiangwei
TI Nanocurcumin attenuates pyroptosis and inflammation through inhibiting
   NF-κB/GSDMD signal in high altitude-associated acute liver injury
SO JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
LA English
DT Article
DE acute liver injury; hypobaric hypoxia; inflammation; nanocurcumin;
   pyroptosis
ID HMGB1 RELEASE; HYPOXIA; ACTIVATION; CURCUMIN; DISEASE; DEATH
AB Exposure to a hypobaric hypoxic environment at high altitudes can lead to liver injury, and mounting evidence indicates that pyroptosis and inflammation play important roles in liver injury. Curcumin (Cur) can inhibit pyroptosis and inflammation. Therefore, our purpose here was to clarify the mechanism underlying the protective effect of nanocurcumin (Ncur) and Cur in a rat model of high altitude-associated acute liver injury. Eighty healthy rats were selected and exposed to different altitudes (6000 or 7000 m) for 0, 24, 48, or 72 h. Fifty normal healthy rats were divided into normal control, high-altitude control, salidroside (40 mg/kg [Sal-40]), Cur (200 mg/kg [Cur-200]), and Ncur (25 mg/kg [Ncur-25]) groups and exposed to a high-altitude hypobaric hypoxic environment (48 h, 7000 m). Serum-liver enzyme activities (alanine transaminase, aspartate transaminase, and lactate dehydrogenase were detected and histopathology of liver injury was evaluated by hematoxylin and eosin staining, and inflammatory factors were detected in liver tissues by enzyme-linked immunosorbent assays. Pyroptosis-associated proteins (gasdermin D, gasdermin D N-terminal [GSDMD-N], pro-Caspase-1, and cleaved-Caspase-1 [cleaved-Casp1]) and inflammation-associated proteins (nuclear factor-kappa B [NF-kappa B], phospho-NF-kappa B [P-NF-kappa B], and high-mobility group protein B1 [HMGB1]) levels were analyzed by immunoblotting. Ncur and Cur inhibited increased serum-liver enzyme activities, alleviated liver injury in rats caused by high-altitude hypobaric hypoxic exposure, and downregulated inflammatory factors, including tumor necrosis factor-alpha, interleukin (IL)-1 beta, IL-6, and IL-18, in rat liver tissues. The level of P-NF-kappa B, GSDMD-N, cleaved-Casp1, and HMGB1 in rat liver tissues increased significantly after high-altitude exposure. Ncur and Cur downregulated P-NF-kappa B, GSDMD-N, cleaved-Casp-1, and HMGB1. Ncur and Cur may inhibit inflammatory responses and pyroptosis in a rat model of high altitude-associated acute liver injury.
C1 [Yang, Xinyue] Gen Hosp Xinjang Mil Command, Key Lab Special Environm Med Xinjiang, Urumqi, Peoples R China.
   [Yang, Xinyue; Dong, Xiang; Li, Jiajia; Shi, Wenhui; Shen, Caifu; Liu, Jiangwei] Xinjiang Med Univ, Grad Sch, Urumqi, Peoples R China.
   [Zhen, Aiping] Acad Mil Med Sci, Inst Pharmacol & Toxicol, Beijing, Peoples R China.
   [Liu, Jiangwei] Gen Hosp Xinjiang Mil Command, Key Lab Special Environm Med Xinjiang, Urumqi 830000, Peoples R China.
C3 Xinjiang Medical University; Academy of Military Medical Sciences -
   China
RP Liu, JW (corresponding author), Gen Hosp Xinjiang Mil Command, Key Lab Special Environm Med Xinjiang, Urumqi 830000, Peoples R China.
EM ljw273273@163.com
RI ; liu, jiangwei/OUH-5011-2025
OI Shen, Caifu/0000-0002-4656-5344; Yang, Xinyue/0000-0001-8230-1322; 
FU Xinjiang Uygur Autonomous Region Department of Education [2019D04022];
   Open Project of Key Laboratory of Xinjiang Uygur Autonomous Region
FX This work was supported by the Open Project of Key Laboratory of
   Xinjiang Uygur Autonomous Region (Grant Number 2019D04022).
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NR 71
TC 8
Z9 12
U1 3
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1095-6670
EI 1099-0461
J9 J BIOCHEM MOL TOXIC
JI J. Biochem. Mol. Toxicol.
PD JAN
PY 2024
VL 38
IS 1
DI 10.1002/jbt.23606
EA DEC 2023
PG 14
WC Biochemistry & Molecular Biology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Toxicology
GA KA8E3
UT WOS:001112783400001
PM 38050447
OA hybrid
DA 2026-05-27
ER

PT J
AU Abou Elazab, MF
   Nasr, NE
   Ahmed, MS
   Alrashdi, BM
   Dahran, N
   Alblihed, MA
   Elmahallawy, EK
AF Abou Elazab, Mohamed F.
   Nasr, Nasr E.
   Ahmed, Mohamed S.
   Alrashdi, Barakat M.
   Dahran, Naief
   Alblihed, Mohamed A.
   Elmahallawy, Ehab Kotb
TI The Effects of Bacterial Lipopolysaccharide (LPS) on Turkey Poults:
   Assessment of Biochemical Parameters and Histopathological Changes
SO VETERINARY SCIENCES
LA English
DT Article
DE LPS; turkey poults; electrophoresis; serum biomarkers; pathology
ID ESCHERICHIA-COLI; ENDOTOXIN; INJURY; LIVER; LUNG; RATS; SALIDROSIDE;
   INHIBITION; METABOLISM; EXPRESSION
AB A lipopolysaccharide (LPS) is a large molecule and an outer membrane glycolipid found in Gram-negative bacteria, including Escherichia coli (E. coli). These molecules (LPS) target acute inflammatory responses and significant physiological changes. Importantly, E. coli is considered one of the most important bacterial causes of avian colibacillosis that affect domestic turkey industry. However, little information is available about the potential influence of LPS on the biochemical parameters and histopathological changes in turkey poults. Therefore, this study aimed to evaluate the influence of bacterial lipopolysaccharide (LPS) molecules on serum biomarkers and histopathological changes in turkey poults. The birds were randomly divided into five groups, as follows: group I did not receive any inoculation; group II was inoculated with sterile saline; and groups III, IV, and V were inoculated intraperitoneally with LPS at 0.01, 0.1, and 1 mg/kg of body weight (BW), respectively. The biochemical parameters and the histopathology of different organs were examined in all birds one day post-inoculation. Our results revealed hypolipidemia, hypoglycemia, a significant decrease in uric acid, and a significant increase in serum activities of aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and creatine kinase (CK), as well as cardiac troponin T concentrations in treated groups. Moreover, there was a significant increase in alpha 1-, beta-, and gamma-globulin concentrations and a decrease in albumin and alpha 2-globulin concentrations in group V. However, a significant increase in alpha 2- and gamma-globulin levels and a decrease in albumin levels were detected in groups III and IV. In addition, significant decreases in the albumin/globulin ratio were recorded in all LPS-treated groups. Hepatocellular and cardiac muscle necrosis, slight renal changes, and massive pulmonary inflammatory reactions were recorded. This study provides valuable information about serum biomarkers, protein fractions, and histopathological changes in turkey poults treated with LPS for further investigations of pathophysiological mechanisms in avian medicine along with biomedical research.
C1 [Abou Elazab, Mohamed F.] Kafrelsheikh Univ, Fac Vet Med, Clin Pathol Dept, Kafr Al Sheikh 33516, Egypt.
   [Nasr, Nasr E.] Kafrelsheikh Univ, Fac Vet Med, Dept Biochem & Clin Biochem, Kafr Al Sheikh 33516, Egypt.
   [Ahmed, Mohamed S.] Kafrelsheikh Univ, Fac Vet Med, Pathol Dept, Kafr Al Sheikh 33516, Egypt.
   [Alrashdi, Barakat M.] Jouf Univ, Coll Sci, Biol Dept, Sakaka 72388, Saudi Arabia.
   [Dahran, Naief] Univ Jeddah, Fac Med, Dept Anat, Jeddah 21959, Saudi Arabia.
   [Alblihed, Mohamed A.] Taif Univ, Coll Med, Dept Microbiol, POB 11099, Taif 21944, Saudi Arabia.
   [Elmahallawy, Ehab Kotb] Sohag Univ, Fac Vet Med, Dept Zoonoses, Sohag 82524, Egypt.
C3 Egyptian Knowledge Bank (EKB); Kafrelsheikh University; Egyptian
   Knowledge Bank (EKB); Kafrelsheikh University; Egyptian Knowledge Bank
   (EKB); Kafrelsheikh University; Al Jouf University; University of
   Jeddah; Taif University; Egyptian Knowledge Bank (EKB); Sohag University
RP Abou Elazab, MF (corresponding author), Kafrelsheikh Univ, Fac Vet Med, Clin Pathol Dept, Kafr Al Sheikh 33516, Egypt.; Elmahallawy, EK (corresponding author), Sohag Univ, Fac Vet Med, Dept Zoonoses, Sohag 82524, Egypt.
EM mohamed.abouelazab@vet.kfs.edu.eg; nasr.nasr@vet.kfs.edu.eg;
   mohamed.abdelrahmanl@vet.kfs.edu.eg; bmalrashdi@ju.edu.sa;
   ndahran@uj.edu.sa; mabulihd@tu.edu.sa; eehaa@unileon.es
RI Kotb Elmahallawy, Ehab/T-9269-2019; Dahran, Naief/AAD-9748-2022;
   ALRASHDI, Barakat/ISB-1904-2023; Alblihed, Mohamed/CAH-4972-2022
OI Kotb Elmahallawy, Ehab/0000-0003-4484-3678; Dahran,
   Naief/0000-0003-3560-8166; 
FU Taif University, Taif, Saudi Arabia [TURSP-2020/93]
FX The authors thank the Taif University Researchers supporting project
   number (TURSP-2020/93), Taif University, Taif, Saudi Arabia, for
   support.
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NR 65
TC 11
Z9 12
U1 1
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2306-7381
J9 VET SCI
JI Vet. Sci.
PD MAY
PY 2022
VL 9
IS 5
AR 240
DI 10.3390/vetsci9050240
PG 13
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 1Q2XZ
UT WOS:000802558300001
PM 35622768
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Li, Y
   Cai, M
   Mao, GX
   Shu, QF
   Liu, XB
   Liu, XL
AF Li, Yan
   Cai, Miao
   Mao, Gen-Xiang
   Shu, Qin-Fen
   Liu, Xiao-Bei
   Liu, Xiao-Li
TI Preclinical Evidence and Possible Mechanisms of Rhodiola rosea L.
   and Its Components for Ischemic Stroke: A Systematic Review and
   Meta-Analysis
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE Rhodiola rosea L; traditional medicine; ischemia stroke; possible
   mechanisms; preclinical evidence
ID GLOBAL CEREBRAL-ISCHEMIA; ANIMAL-EXPERIMENTS; SALIDROSIDE; INJURY;
   THROMBOLYSIS; GUIDELINES; TRIAL
AB Background: Rhodiola rosea L. has long been used as traditional medicines in Europe and Asia to treat a variety of common conditions and diseases including Alzheimer's disease, cardiovascular disease, cognitive dysfunctions, cancer, and stroke. Previous studies reported that Rhodiola rosea L. and its components (RRC) improve ischemia stroke in animal models. Here, we conducted a systematic review and meta-analysis for preclinical studies to evaluate the effects of RRC and the probable neuroprotective mechanisms in ischemic stroke.Methods: Studies of RRC on ischemic stroke animal models were searched in seven databases from inception to Oct 2021. The primary measured outcomes included the neural functional deficit score (NFS), infarct volume (IV), brain water content, cell viability, apoptotic cells, terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-biotin nick end labeling (TUNEL)-positive cells, B-cell lymphoma-2 (Bcl-2) level and tumor necrosis factor-alpha (TNF-alpha) level. The secondary outcome measures were possible mechanisms of RRC for ischemic stroke. All the data were analyzed via RevMan version 5.3.Results: 15 studies involving 345 animals were identified. Methodological quality for each included studies was accessed according to the CAMARADES 10-item checklist. The quality score of studies range from 1 to 7, and the median was 5.53. Pooled preclinical data showed that compared with the controls, RRC could improve NFS (Zea Longa (p < 0.01), modified neurological severity score (mNSS) (p < 0.01), rotarod tests (p < 0.01), IV (p < 0.01), as well as brain edema (p < 0.01). It also can increase cell viability (p < 0.01), Bcl-2 level (p < 0.01) and reduce TNF-alpha level (p < 0.01), TUNEL-positive cells (p < 0.01), apoptotic cells (p < 0.01).Conclusion: The findings suggested that RRC can improve ischemia stroke. The possible mechanisms of RRC are largely through antioxidant, anti-apoptosis activities, anti-inflammatory, repressing lipid peroxidation, antigliosis, and alleviating the pathological blood brain barrier damage.
C1 [Li, Yan; Cai, Miao; Shu, Qin-Fen; Liu, Xiao-Li] Zhejiang Hosp, Dept Neurol, Hangzhou, Peoples R China.
   [Mao, Gen-Xiang] Zhejiang Hosp, Zhejiang Prov Key Lab Geriatr, Hangzhou, Peoples R China.
   [Mao, Gen-Xiang] Zhejiang Hosp, Geriatr Inst Zhejiang Prov, Dept Geriatr, Hangzhou, Peoples R China.
   [Liu, Xiao-Bei] 1 Peoples Hosp Pinghu, Dept Neurol, Jiaxing, Peoples R China.
RP Liu, XL (corresponding author), Zhejiang Hosp, Dept Neurol, Hangzhou, Peoples R China.; Liu, XB (corresponding author), 1 Peoples Hosp Pinghu, Dept Neurol, Jiaxing, Peoples R China.
EM phliuxiaobei@163.com; liuxiaoli@126.com
FU National Natural Science Foundation of China [81771520]
FX Funding This work was supported by the grant of National Natural Science
   Foundation of China (81771520).
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NR 55
TC 13
Z9 14
U1 0
U2 30
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD NOV 5
PY 2021
VL 12
AR 736198
DI 10.3389/fphar.2021.736198
PG 16
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA WZ7SY
UT WOS:000720165100001
PM 34803686
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Li, J
   Chen, YF
AF Li, Jing
   Chen, Yongfeng
TI Rhodiola rosea polysaccharides promote the proliferation of bone
   marrow haematopoietic progenitor cells and stromal cells in mice with
   aplastic anaemia
SO PHARMACEUTICAL BIOLOGY
LA English
DT Article
DE Rhodiola rosea L; haematopoietic progenitor cells; bone marrow stromal
   cells; mice with aplastic anaemia; haematopoiesis regulation
ID OXIDATIVE STRESS; FAS ANTIGEN; SALIDROSIDE; EXPRESSION; SURVIVAL;
   RECEPTOR; EXTRACT; LIGAND; DEATH
AB Context The effects of Rhodiola rosea L. (Crassulaceae) polysaccharides (RRPs) on haematopoiesis are poorly understood. Objective To determine the effects of RRPs on haematopoiesis in mice with aplastic anaemia. Materials and methods Aplastic anaemia was induced in Kunming mice by Co-60 gamma (2.0 Gy) irradiation and cyclophosphamide administration (50 mg/kg/day for 3 consecutive days; intraperitoneal injection). The in vivo effects of RRPs (10, 20, and 40 mg/kg; intraperitoneal injection) on haematopoiesis were analyzed using peripheral blood tests, histopathological examination of haematopoietic tissues, culture of haematopoietic progenitors and bone marrow stromal cells (BMSCs), and Western blotting of Fas and Fas ligand (FasL). The in vitro effects of RRPs on bone-marrow haematopoietic progenitors and BMSCs were also evaluated. Results Compared to anaemic controls, high-dose RRPs (40 mg/kg) significantly increased red blood cells (8.21 +/- 0.57835 versus 6.13 +/- 1.34623 x 10(12)/L), white blood cells (5.11 +/- 1.6141 versus l.54 +/- 1.1539 x 10(9)/L), and BMSCs (10.33 +/- 1.5542 versus 5.87 +/- 3.1567 x 10(12)/L) in mice with aplastic anaemia (all p < 0.01). High-dose RRPs significantly increased the formation of colony-forming unit-granulocyte macrophage (CFU-GM), burst-forming unit-erythroid (BFU-E), and colony-forming unit-erythroid (CFU-E; p < 0.01). Fas and FasL protein expression in BMSCs decreased after RRPs administration. Especially at the high dose, RRPs (150 mu g/mL) significantly promoted in vitro CFUs-E, BFUs-E, and CFUs-GM formation. RRPs (150-300 mu g/mL) also promoted BMSC proliferation. Discussion and conclusions RRPs helped to promote haematopoietic recovery in mice with aplastic anaemia, facilitating haematopoietic tissue recovery. This study indicated some mechanisms of the haematopoietic regulatory effects of RRPs. Our findings provide a laboratory basis for clinical research on RRPs.
C1 [Li, Jing] North Sichuan Med Coll, Dept Histol & Embryol, Nanchong 637000, Sichuan, Peoples R China.
   [Chen, Yongfeng] Taizhou Univ, Dept Basic Med Sci, Med Coll, Taizhou, Peoples R China.
C3 North Sichuan Medical University
RP Li, J (corresponding author), North Sichuan Med Coll, Dept Histol & Embryol, Nanchong 637000, Sichuan, Peoples R China.
EM Jingli@nsmc.edu.cn
OI Chen, Yongfeng/0000-0003-4488-0380; LI, Jing/0009-0009-9298-5188
FU Scientific Research Project of the Sichuan Province Education Department
   [16ZA0241]
FX This research was supported by the Scientific Research Project of the
   Sichuan Province Education Department [No. 16ZA0241].
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NR 41
TC 6
Z9 8
U1 2
U2 51
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1388-0209
EI 1744-5116
J9 PHARM BIOL
JI Pharm. Biol.
PD DEC 31
PY 2022
VL 60
IS 1
BP 1160
EP 1168
DI 10.1080/13880209.2022.2083187
PG 9
WC Plant Sciences; Medical Laboratory Technology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Medical Laboratory Technology; Pharmacology & Pharmacy
GA 2A7DS
UT WOS:000809658700001
PM 35695011
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Saad, HM
   Atef, E
   Elsayed, AE
AF Saad, Hebatallah M.
   Atef, Esraa
   Elsayed, Abeer E.
TI New Insights on the Potential Role of Pyroptosis in Parkinson's
   Neuropathology and Therapeutic Targeting of NLRP3 Inflammasome with
   Recent Advances in Nanoparticle-Based miRNA Therapeutics
SO MOLECULAR NEUROBIOLOGY
LA English
DT Review
DE Pyroptosis; ASC; Inflammasome; Parkinson's disorder
ID IN-VITRO MODEL; CELL-DEATH; MOUSE MODEL; GASDERMIN D; DISEASE;
   ACTIVATION; GSDMD; NEUROINFLAMMATION; SALIDROSIDE; MECHANISM
AB Parkinson's disease (PD) is a widespread neurodegenerative disorder characterized by the gradual degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc). This review aims to summarize the recent advancements in the pathophysiological mechanisms of pyroptosis, mediated by NLRP3 inflammasome, in advancing PD and the anti-pyroptotic agents that target NLRP3 inflammatory pathways and miRNA. PD pathophysiology is primarily linked to the aggregation of alpha-synuclein, the overproduction of reactive oxygen species (ROS), and the development of neuroinflammation due to microglial activation. Prior research indicated that a significant quantity of microglia is activated in both PD patients and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse models, triggering neuroinflammation and resulting in a cascade of cellular death. Microglia possess an inflammatory complex pathway termed the nucleotide-binding oligomerization domain-, leucine-rich repeat, and pyrin domain-containing 3 (NLRP3) inflammasome. Activation of the NLRP-3 inflammasome results in innate cytokines maturation, including IL-18 and IL-1 beta, which initiates the neuroinflammatory signal and induces a type of inflammatory cell death known as pyroptosis. Upon neuronal damage, intracellular levels of damage-associated molecular patterns (DAMPs), including reactive oxygen species (ROS), would build. DAMPs induce unregulated cell death and subsequent release of oxidative intermediates and pro-inflammatory cytokines, leading to the progression of PD. Thus, targeting of neuroinflammation using antipyroptotic medications can be efficiently achieved by blocking NLRP3 and obstructing IL-1 beta signaling and release. Furthermore, many research studies showed that miRNAs have been identified as regulators of the NLRP3 inflammasome and Nrf2 signal, which subsequently modulate the NLRP3-Nrf2 axis in PD. Nanotechnology promises potential for the advancement of miRNA-based therapies. Nanoparticles that ensure miRNA stability, traverse the blood-brain barrier (BBB) and distribute miRNA targeting regions needed to be created. In conclusion, targeting the pyroptosis pathway via NLRP3 or miRNA may serve as a prospective therapeutic strategy for PD in the future.
C1 [Saad, Hebatallah M.] Matrouh Univ, Fac Vet Med, Dept Pathol, Marsa Matruh 51744, Egypt.
   [Atef, Esraa] Menoufia Univ, Fac Med, Dept Med Physiol, Shibin Al Kawm 32511, Egypt.
   [Elsayed, Abeer E.] Matrouh Univ, Fac Vet Med, Dept Pathol, Marsa Matruh 51744, Egypt.
C3 Matrouh University; Egyptian Knowledge Bank (EKB); Menofia University;
   Matrouh University
RP Saad, HM (corresponding author), Matrouh Univ, Fac Vet Med, Dept Pathol, Marsa Matruh 51744, Egypt.
EM heba.magdy@mau.edu.eg; ISRAA.ATEF924@med.menofia.edu.eg;
   abeer.esmael@mau.edu.eg
RI Saad, Hebatallah M/ABF-6201-2020
OI Saad, Hebatallah M/0000-0001-9555-7300; Elsayed,
   Abeer/0009-0003-0900-9896
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NR 158
TC 5
Z9 6
U1 2
U2 8
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0893-7648
EI 1559-1182
J9 MOL NEUROBIOL
JI Mol. Neurobiol.
PD JUL
PY 2025
VL 62
IS 7
BP 9365
EP 9384
DI 10.1007/s12035-025-04818-4
EA MAR 2025
PG 20
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 4KS2C
UT WOS:001448766500001
PM 40100493
DA 2026-05-27
ER

PT J
AU Guo, C
   Huang, QX
   Wang, YS
   Yao, Y
   Li, J
   Chen, JJ
   Wu, MX
   Zhang, ZP
   Mingyao, E
   Qi, HY
   Ji, P
   Liu, Q
   Zhao, DQ
   Su, H
   Qi, WX
   Li, XY
AF Guo, Chen
   Huang, Qingxia
   Wang, Yisa
   Yao, Yao
   Li, Jing
   Chen, Jinjin
   Wu, Mingxia
   Zhang, Zepeng
   Mingyao, E.
   Qi, Hongyu
   Ji, Peng
   Liu, Qing
   Zhao, Daqing
   Su, Hang
   Qi, Wenxiu
   Li, Xiangyan
TI Therapeutic application of natural products: NAD+ metabolism
   as potential target
SO PHYTOMEDICINE
LA English
DT Review
DE Natural products; Nicotinamide adenine dinucleotide; NAD(+) metabolism;
   Diseases; Toxicology
ID NOTOGINSENOSIDE R1; ENERGY-METABOLISM; CEREBRAL-ISCHEMIA; OXIDATIVE
   STRESS; NAMPT; CANCER; INHIBITION; PROTECTS; CELLS; APOPTOSIS
AB Background: Nicotinamide adenine dinucleotide (NAD(+)) metabolism is involved in the entire physiopathological process and is critical to human health. Long-term imbalance in NAD(+) homeostasis is associated with various diseases, including non-alcoholic fatty liver disease, diabetes mellitus, cardiovascular diseases, neurodegenerative disorders, aging, and cancer, making it a potential target for effective therapeutic strategies. Currently, several natural products that target NAD(+) metabolism have been widely reported to have significant therapeutic effects, but systematic summaries are lacking.
   Purpose: To summarize the latest findings on the prevention and treatment of various diseases through the regulation of NAD(+) metabolism by various natural products in vivo and in vitro models, and evaluate the toxicities of the natural products.
   Methods: PubMed, Web of Science, and ScienceDirect were searched using the keywords "natural products sources," "toxicology," "NAD(+) clinical trials," and "NAD(+)," and/or paired with "natural products" and "diseases" for studies published within the last decade until January 2023.
   Results: We found that the natural products mainly include phenols (curcumin, cyclocurcumin, 4-hydroxybenzyl alcohol, salvianolic acid B, pterostilbene, EGCG), flavonoids (pinostrobin, apigenin, acacetin, tilianin, kaempferol, quercetin, isoliquiritigenin, luteolin, silybin, hydroxysafflor yellow A, scutellarin), glycosides (salidroside), quinones (emodin, embelin, beta-LAPachone, shikonin), terpenoids (notoginsenoside R1, ginsenoside F2, ginsenoside Rd, ginsenoside Rb1, ginsenoside Rg3, thymoquinone, genipin), pyrazines (tetramethylpyrazine), alkaloids (evodiamine, berberine), and phenylpropanoids (ferulic acid). These natural products have antioxidant, energy-producing, anti-inflammatory, anti-apoptotic and anti-aging effects, which mainly influence the NAMPT/NAD(+)/SIRT, AMPK/SIRT1/PGC-1 alpha, Nrf2/HO-1, PKCs/PARPs/NF-kappa B, and AMPK/Nrf2/mTOR signaling pathways, thereby regulating NAD(+) metabolism to prevent and treat various diseases. These natural products have been shown to be safe, tolerable and have fewer adverse effects in various in vivo and in vitro studies and clinical trials.
   Conclusion: We evaluated the toxic effects of natural products and summarized the available clinical trials on NAD(+) metabolism, as well as the recent advances in the therapeutic application of natural products targeting NAD(+) metabolism, with the aim to provide new insights into the treatment of multiple disorders.
C1 [Guo, Chen; Huang, Qingxia; Wang, Yisa; Yao, Yao; Li, Jing; Chen, Jinjin; Wu, Mingxia; Zhang, Zepeng; Mingyao, E.; Qi, Hongyu; Ji, Peng; Liu, Qing; Zhao, Daqing; Su, Hang; Qi, Wenxiu; Li, Xiangyan] Changchun Univ Chinese Med, Northeast Asia Res Inst Tradit Chinese Med, Key Lab Act Subst & Biol Mech Ginseng Efficacy, Minis Educ,Jilin Prov Key Lab Biomacromol Chinese, Changchun 130117, Jilin, Peoples R China.
   [Huang, Qingxia; Zhang, Zepeng] Changchun Univ Chinese Med, Coll Tradit Chinese Med, Res Ctr Tradit Chinese Med, Changchun 130021, Jilin, Peoples R China.
C3 Changchun University of Chinese Medicine; Changchun University of
   Chinese Medicine
RP Qi, WX; Li, XY (corresponding author), Changchun Univ Chinese Med, Northeast Asia Res Inst Tradit Chinese Med, Key Lab Act Subst & Biol Mech Ginseng Efficacy, Minis Educ,Jilin Prov Key Lab Biomacromol Chinese, Changchun 130117, Jilin, Peoples R China.
EM qiwenxiu0517@163.com; xiangyan_li1981@163.com
RI ; Qi, Wenxiu/NTQ-3751-2025; Li, Xiangyan/JDW-4460-2023; Chen,
   Jinjin/PUF-4037-2026; Liu, Qing/KCJ-7082-2024; Zhang,
   Zepeng/LLK-2494-2024
OI Huang, Qingxia/0000-0001-8272-0201; Li, Xiangyan/0000-0001-6780-6314;
   Zhang, Zepeng/0000-0001-7057-1341
FU National Natural Science Foundation of China [82104432, U19A2013];
   Science and Tech-nology Development Plan Project of Jilin Province
   [YDZJ202201ZYTS270, 202002053JC]; Jilin Provincial Administration of
   Traditional Chinese Medicine [20222222]
FX Acknowlegement This work was supported by the National Natural Science
   Foundation of China (Grant No. 82104432 and U19A2013) , the Science and
   Tech-nology Development Plan Project of Jilin Province (Grant No.
   YDZJ202201ZYTS270 and 202002053JC) , and the Jilin Provincial
   Administration of Traditional Chinese Medicine (Grant No. 20222222) .
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NR 229
TC 101
Z9 109
U1 35
U2 215
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD JUN
PY 2023
VL 114
AR 154768
DI 10.1016/j.phymed.2023.154768
EA MAR 2023
PG 29
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA A6NT2
UT WOS:000956276000001
PM 36948143
DA 2026-05-27
ER

PT J
AU Amsterdam, JD
   Panossian, AG
AF Amsterdam, Jay D.
   Panossian, Alexander G.
TI Rhodiola rosea L. as a putative botanical antidepressant
SO PHYTOMEDICINE
LA English
DT Article
DE Rhodiola rosea L., Depression; Clinical study; Pharmacology; Molecular
   networks
ID ALTERNATIVE MEDICINE USE; PITUITARY-ADRENAL AXIS;
   CENTRAL-NERVOUS-SYSTEM; PLASMA NEUROPEPTIDE-Y; STAR-ASTERISK-D;
   UNITED-STATES; EXTRACT SHR-5; DEPRESSION; STRESS; COMPLEMENTARY
AB Background: Rhodiola rosea (R. rosea) is a botanical adaptogen with putative anti-stress and antidepressant properties. Evidence-based data supporting the effectiveness of R. rosea for depression in adults is limited, and therefore a comprehensive review of available animal and human studies suggesting a putative antidepressant action is warranted.
   Purpose: A review of the literature was undertaken to ascertain studies of possible antidepressant mechanisms of action and studies of the safety and effectiveness of R. rosea extracts in animals and adult humans.
   Methods: A search of MEDLINE and the Russian state library database was conducted (up to October 2015) on R. rosea.
   Results: Mechanism of action: R. rosea extracts and its purified constituent, salidroside, has been shown to produce a variety of mediator interactions with several molecular networks of neuroendocrine-immune and neurotransmitter receptor systems likely to be involved in the pathophysiology of depression. A wide variety of preclinical in vivo and ex vivo studies with laboratory animals suggests the presence of several biochemical and pharmacological antidepressant-like actions.
   Effectiveness: Clinical assessment of R. rosea L. rhizome extracts in humans with various depressive syndromes is based upon results from two randomized, double-blind, placebo-controlled trials of 146 subjects with major depressive disorder and seven open-label studies totaling 714 individuals with stress-induced mild depression (diagnosed as asthenic syndrome or psychoneurosis). Overall, results of these studies suggests a possible antidepressant action for R. rosea extract in adult humans.
   Safety: In contrast to most conventional antidepressants, R. rosea extract appears to be well-tolerated in short-term studies with a favorable safety profile.
   Conclusions: R. rosea demonstrates multi-target effects on various levels of the regulation of cell response to stress, affecting various components of the neuroendocrine, neurotransmitter receptor and molecular networks associated with possible beneficial effects on mood. (C) 2016 Elsevier GmbH. All rights reserved.
C1 [Amsterdam, Jay D.] Univ Penn, Sch Med, Dept Psychiat, Depress Res Unit,Perelman Sch Med, Philadelphia, PA 19104 USA.
   [Panossian, Alexander G.] Swedish Herbal Inst, Res & Dev Unit, Vallberga, Halland, Sweden.
C3 University of Pennsylvania
RP Amsterdam, JD (corresponding author), Univ Penn, Sch Med, Dept Psychiat, Depress Res Unit,Perelman Sch Med, Philadelphia, PA 19104 USA.
EM jamsterd@mail.med.upenn.edu
RI Panossian, Alexander/AAK-8720-2021
OI Panossian, Alexander/0000-0002-8467-4525
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NR 128
TC 91
Z9 113
U1 1
U2 80
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD JUN 15
PY 2016
VL 23
IS 7
BP 770
EP 783
DI 10.1016/j.phymed.2016.02.009
PG 14
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA DM7IM
UT WOS:000376533500011
PM 27013349
DA 2026-05-27
ER

PT J
AU Das, A
   Kim, DW
   Khadka, P
   Rakwal, R
   Rohila, JS
AF Das, Aayudh
   Kim, Dea-Wook
   Khadka, Pramod
   Rakwal, Randeep
   Rohila, Jai S.
TI Unraveling Key Metabolomic Alterations in Wheat Embryos Derived from
   Freshly Harvested and Water-Imbibed Seeds of Two Wheat Cultivars with
   Contrasting Dormancy Status
SO FRONTIERS IN PLANT SCIENCE
LA English
DT Article
DE wheat; metabolomic profile; pre-harvest sprouting; PHS; raffinose;
   oligosaccharide; oxalate
ID PREHARVEST SPROUTING RESISTANCE; ABSCISIC-ACID; GENE-EXPRESSION; OXALATE
   OXIDASE; COMMON WHEAT; BREAD-WHEAT; MAJOR QTL; FUNCTIONAL GENOMICS;
   ENZYMATIC-ACTIVITY; CHROMOSOME 4A
AB Untimely rains in wheat fields during harvest season can cause pre-harvest sprouting (PHS), which deteriorates the yield and quality of wheat crop. Metabolic homeostasis of the embryo plays a role in seed dormancy, determining the status of the maturing grains either as dormant (PHS-tolerant) or non-dormant (PHS-susceptible). Very little is known for direct measurements of global metabolites in embryonic tissues of dormant and nondormant wheat seeds. In this study, physiologically matured and freshly harvested wheat seeds of PHS-tolerant (cv. Sukang, dormant) and PHS-susceptible (cv. Baegjoong, non-dormant) cultivars were water-imbibed, and the isolated embryos were subjected to high-throughput, global non-targeted metabolomic profiling. A careful comparison of identified metabolites between Sukang and Baegjoong embryos at 0 and 48 h after imbibition revealed that several key metabolic pathways [such as: lipids, fatty acids, oxalate, hormones, the raffinose family of oligosaccharides (RFOs), and amino acids] and phytochemicals were differentially regulated between dormant and nondormant varieties. Most of the membrane lipids were highly reduced in Baegjoong compared to Sukang, which indicates that the cell membrane instability in response to imbibition could also be a key factor in non-dormant wheat varieties for their untimely germination. This study revealed that several key marker metabolites (e. g., RFOs: glucose, fructose, maltose, and verbascose), were highly expressed in Baegjoong after imbibition. Furthermore, the data showed that the key secondary metabolites and phytochemicals (vitexin, chrysoeriol, ferulate, salidroside and gentisic acid), with known antioxidant properties, were comparatively low at basal levels in PHS-susceptible, non-dormant cultivar, Baegjoong. In conclusion, the results of this investigation revealed that after imbibition the metabolic homeostasis of dormant wheat is significantly less affected compared to non-dormant wheat. The inferences from this study combined with proteomic and transcriptomic studies will advance the molecular understanding of the pathways and enzyme regulations during PHS.
C1 [Das, Aayudh] Univ Vermont, Dept Plant Biol, Burlington, VT USA.
   [Das, Aayudh; Khadka, Pramod; Rohila, Jai S.] South Dakota State Univ, Dept Biol & Microbiol, Brookings, SD 57007 USA.
   [Kim, Dea-Wook] Rural Dev Adm, Natl Inst Crop Sci, Wanju Gun, South Korea.
   [Rakwal, Randeep] Univ Tsukuba, Fac Hlth & Sport Sci, Tsukuba, Ibaraki, Japan.
   [Khadka, Pramod] Univ Virginia, Dept Biol, Charlottesville, VA USA.
   [Rohila, Jai S.] USDA ARS, Dale Bumpers Natl Rice Res Ctr, Stuttgart, AR 72160 USA.
C3 University of Vermont; South Dakota State University; Rural Development
   Administration (RDA), Republic of Korea; National Institute of Crop
   Science; University of Tsukuba; University of Virginia; United States
   Department of Agriculture (USDA)
RP Rohila, JS (corresponding author), South Dakota State Univ, Dept Biol & Microbiol, Brookings, SD 57007 USA.; Rohila, JS (corresponding author), USDA ARS, Dale Bumpers Natl Rice Res Ctr, Stuttgart, AR 72160 USA.
EM jai.rohila@ars.usda.gov
RI Das, Aayudh/AHB-4541-2022; Rohila, Jai/A-2175-2013
OI Das, Aayudh/0000-0001-8892-5398; Rohila, Jai/0000-0002-4041-5804
FU Cooperative Research Program for Agriculture Science & Technology
   Development [PJ01149902]; Rural Development Administration, Republic of
   Korea; USDA hatch [SD00H541-15]
FX JR and D-WK acknowledge support from Cooperative Research Program for
   Agriculture Science & Technology Development (Project no. PJ01149902),
   Rural Development Administration, Republic of Korea. JR also
   acknowledges the USDA hatch project (SD00H541-15). We sincerely
   acknowledge Dr. Anna McClung for discussion, encouragement, and
   constructive comments during the writing of this manuscript. The U.S.
   Department of Agriculture-Agricultural Research Service (USDA-ARS), is
   an equal opportunity/affirmative action employer and all agency services
   are available without discrimination. Mention of commercial products and
   organizations in this manuscript is solely to provide specific
   information. It does not constitute endorsement by USDA-ARS over other
   products and organizations not mentioned.
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NR 122
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Z9 24
U1 0
U2 38
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-462X
J9 FRONT PLANT SCI
JI Front. Plant Sci.
PD JUL 12
PY 2017
VL 8
AR 1203
DI 10.3389/fpls.2017.01203
PG 16
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences
GA FA2KP
UT WOS:000405270600001
PM 28747920
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Yang, XY
   Li, JJ
   Ma, Y
   Dong, X
   Qu, JQ
   Liang, FX
   Liu, JW
AF Yang, Xinyue
   Li, Jiajia
   Ma, Yan
   Dong, Xiang
   Qu, Jinquan
   Liang, Feixing
   Liu, Jiangwei
TI Curcumin-mediated enhancement of lung barrier function in rats with
   high-altitude-associated acute lung injury via inhibition of
   inflammatory response
SO RESPIRATORY RESEARCH
LA English
DT Article
DE High altitude; Hypobaric hypoxia; Acute lung injury; Arterial blood gas;
   Curcumin
ID BLOOD-GAS; FEATURES
AB BackgroundExposure to a hypobaric hypoxic environment at high altitudes can lead to lung injury. In this study, we aimed to determine whether curcumin (Cur) could improve lung barrier function and protect against high-altitude-associated acute lung injury.MethodsTwo hundred healthy rats were randomly divided into standard control, high-altitude control (HC), salidroside (40 mg/kg, positive control), and Cur (200 mg/kg) groups. Each group was further divided into five subgroups. Basic vital signs, lung injury histopathology, routine blood parameters, plasma lactate level, and arterial blood gas indicators were evaluated. Protein and inflammatory factor (tumor necrosis factor alpha (TNF-alpha), interleukin [IL]-1 beta, IL-6, and IL-10) concentrations in bronchoalveolar lavage fluid (BALF) were determined using the bicinchoninic acid method and enzyme-linked immunosorbent assay, respectively. Inflammation-related and lung barrier function-related proteins were analyzed using immunoblotting.ResultsCur improved blood routine indicators such as hemoglobin and hematocrit and reduced the BALF protein content and TNF-alpha, IL-1 beta, and IL-6 levels compared with those in the HC group. It increased IL-10 levels and reduced pulmonary capillary congestion, alveolar hemorrhage, and the degree of pulmonary interstitial edema. It increased oxygen partial pressure, oxygen saturation, carbonic acid hydrogen radical, and base excess levels, and the expression of zonula occludens 1, occludin, claudin-4, and reduced carbon dioxide partial pressure, plasma lactic acid, and the expression of phospho-nuclear factor kappa.ConclusionsExposure to a high-altitude environment for 48 h resulted in severe lung injury in rats. Cur improved lung barrier function and alleviated acute lung injury in rats at high altitudes.
   center dot Curcumin (Cur) improves lung barrier function under high-altitude stress in rats center dot Cur mitigated acute lung injury under high-altitude stress center dot Cur improved hemoglobin and hematocrit levels under high-altitude stress center dot Cur reduced bronchoalveolar lavage fluid protein content under high-altitude stress center dot Cur reduced inflammatory factor TNF-alpha, IL-alpha, IL-6 levels under high-altitude stress
C1 [Yang, Xinyue; Li, Jiajia; Dong, Xiang; Qu, Jinquan; Liang, Feixing; Liu, Jiangwei] Gen Hosp Xinjiang Mil Command, Key Lab Special Environm Med Xinjiang, Urumqi 830000, Peoples R China.
   [Yang, Xinyue] Xinjiang Med Univ, Grad Sch, Urumqi 830000, Peoples R China.
   [Ma, Yan] Xinjiang Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Urumqi 830054, Peoples R China.
   [Li, Jiajia] Xinjiang Med Univ, Coll Pharm, Urumqi 830000, Peoples R China.
C3 Xinjiang Medical University; Xinjiang Medical University; Xinjiang
   Medical University
RP Liu, JW (corresponding author), Gen Hosp Xinjiang Mil Command, Key Lab Special Environm Med Xinjiang, Urumqi 830000, Peoples R China.
EM ljw273273@163.com
RI liu, jiangwei/OUH-5011-2025
FU The Open Project of Key Laboratory of Xinjiang Uygur Autonomous Region
FX Not applicable.
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NR 59
TC 12
Z9 12
U1 5
U2 33
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1465-993X
J9 RESP RES
JI Respir. Res.
PD SEP 28
PY 2024
VL 25
IS 1
AR 354
DI 10.1186/s12931-024-02975-z
PG 14
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA H6W7S
UT WOS:001324831900005
PM 39342264
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Hou, Y
   Tang, Y
   Wang, XB
   Ai, XP
   Wang, HL
   Li, XH
   Chen, XR
   Zhang, Y
   Hu, Y
   Meng, XL
   Zhang, J
AF Hou, Ya
   Tang, Yan
   Wang, Xiaobo
   Ai, Xiaopeng
   Wang, Hongling
   Li, Xuanhao
   Chen, Xiaorui
   Zhang, Yi
   Hu, Yao
   Meng, Xianli
   Zhang, Jing
TI Rhodiola Crenulata ameliorates exhaustive exercise-induced
   fatigue in mice by suppressing mitophagy in skeletal muscle
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE Rhodiola crenulata oral liquid; quadriceps femoris; loaded swimming;
   anti-fatigue; mitophagy
ID OXIDATIVE STRESS; HIPPOCAMPAL-NEURONS; MTOR PATHWAY; SALIDROSIDE;
   AUTOPHAGY; P62; MECHANISMS; INDUCTION; APOPTOSIS; EXTRACT
AB The aim of present study was to evaluate the potential effects of Rhodiola crenulata oral liquid (RCOL) on exhaustive exercise (EE)-induced fatigue in mice. Male Institute of Cancer Research mice from five treatment groups (n=10 per group) were orally administered with sterilized water for the Control and EE groups and/or RCOL at doses of 1.02, 3.03 and 6.06 ml/kg/day, once daily for 2 weeks. Anti-fatigue activity was subsequently evaluated by measuring the levels of creatine kinase (CK), lactic acid (LA), lactate dehydrogenase (LDH), malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) and total anti-oxidative capability (T-AOC). Histopathology was assessed using hematoxylin and eosin staining. Ultrastructures of mitochondria were observed by transmission electron microscopy. Energy supply capacity was assessed using citrate synthase (CS), succinate dehydrogenase (SDH), Na+-K+-ATPase, and liver and quadriceps glycogen content assays. Expression levels of mRNA and protein associated with mitophagy in the skeletal muscle were measured by reverse transcription-quantitative PCR and western blotting, respectively. RCOL was observed to markedly inhibit fatigue-induced oxidative stress by increasing the activities of SOD, CAT and T-AOC, whilst reducing the accumulation of LA, CK, LDH and MDA. Histological analysis of the quadriceps femoris tissue suggested increased numbers of muscle fibers in the RCOL groups compared with those in the EE group. RCOL administration was found to reverse EE-induced mitochondrial structural damage and alleviated defects inflicted onto the energy supply mechanism by increasing CS, SDH, Na+-K+-ATPase and glycogen levels. Additionally, RCOL reduced the protein expression of PTEN-induced kinase 1 (PINK1), Parkin, microtubule-associated proteins 1A/1B light chain 3, sequestosome 1 and ubiquitin, whilst lowering the gene expression of PINK1 and Parkin. Taken together, results from the present study clarified the anti-fatigue effect of RCOL, where the underlying mechanism may be associated with increased antioxidant activity, enhanced energy production and the inhibition of mitophagy by suppressing the PINK1/Parkin signaling pathway.
C1 [Hou, Ya; Tang, Yan; Wang, Xiaobo; Ai, Xiaopeng; Li, Xuanhao; Chen, Xiaorui] Chengdu Univ Tradit Chinese Med, Sch Pharm, Dept Pharmacol Chinese Mat Med, Chengdu 611137, Sichuan, Peoples R China.
   [Wang, Hongling; Zhang, Yi; Zhang, Jing] Chengdu Univ Tradit Chinese Med, Ethn Med Acad Heritage Innovat Res Ctr, 1166 Liutai St, Chengdu 611137, Sichuan, Peoples R China.
   [Hu, Yao] Chengdu Univ Tradit Chinese Med, Interdisciplinary Lab Exercise & Med, Chengdu 611137, Sichuan, Peoples R China.
   [Meng, Xianli] Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, 1166 Liutai St, Chengdu 611137, Sichuan, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine; Chengdu University of Traditional
   Chinese Medicine; Chengdu University of Traditional Chinese Medicine
RP Zhang, J (corresponding author), Chengdu Univ Tradit Chinese Med, Ethn Med Acad Heritage Innovat Res Ctr, 1166 Liutai St, Chengdu 611137, Sichuan, Peoples R China.; Meng, XL (corresponding author), Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, 1166 Liutai St, Chengdu 611137, Sichuan, Peoples R China.
EM xlm999@cdutcm.edu.cn; 31649123@qq.com
FU National Key R&D Program of China [2017YFC1703904]; Major Science and
   Technology Project of Sichuan Science and Technology Department
   [19SYXHZ0095]; National Natural Science Foundation of China [81773974,
   81203000]; Science & Technology Department of Sichuan Province
   [2018JY0467]; Sichuan Science and Technology Program [2019YJ0480];
   First-Class Interdisciplinary Project of Chengdu University of
   Traditional Chinese Medicine [CZYJC-1903]
FX The present study was supported by The National Key R&D Program of China
   (grant no. 2017YFC1703904), The Major Science and Technology Project of
   Sichuan Science and Technology Department (grant no. 19SYXHZ0095), The
   National Natural Science Foundation of China (grant nos. 81773974 and
   81203000), The Science & Technology Department of Sichuan Province
   (grant no. 2018JY0467), Sichuan Science and Technology Program (grant
   no. 2019YJ0480), and The First-Class Interdisciplinary Project of
   Chengdu University of Traditional Chinese Medicine (grant no.
   CZYJC-1903).
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NR 62
TC 46
Z9 53
U1 3
U2 63
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD OCT
PY 2020
VL 20
IS 4
BP 3161
EP 3173
DI 10.3892/etm.2020.9072
PG 13
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA NW4UQ
UT WOS:000575004100028
PM 32855685
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Genovese, C
   Garozzo, A
   D'Angeli, F
   Malfa, GA
   Bellia, F
   Tomasello, B
   Nicolosi, D
   Malaguarnera, R
   Ronsisvalle, S
   Guadagni, F
   Acquaviva, R
AF Genovese, Carlo
   Garozzo, Adriana
   D'Angeli, Floriana
   Malfa, Giuseppe Antonio
   Bellia, Francesco
   Tomasello, Barbara
   Nicolosi, Daria
   Malaguarnera, Roberta
   Ronsisvalle, Simone
   Guadagni, Fiorella
   Acquaviva, Rosaria
TI Orobanche crenata Forssk. Extract Affects Human Breast Cancer
   Cell MCF-7 Survival and Viral Replication
SO CELLS
LA English
DT Article
DE Orobanche crenata extract; MCF-7 cells; MDA-MB-231 cells; Herpes simplex
   virus; Coxsackievirus; parasitic plant
ID CYCLE ARREST; IN-VITRO; ANTIVIRAL ACTIVITY; LUTEOLIN; ANTIOXIDANT;
   SALIDROSIDE; APOPTOSIS; APIGENIN; THERAPY; L.
AB Background: Breast cancer (BC) is the leading cause of death worldwide. The severity of BC strictly depends on the molecular subtype. The less aggressive hormone-positive subtype is treated with adjuvant endocrine therapy (AET), which causes both physical and psychological side effects. This condition strongly impacts the adherence and persistence of AET among oncologic patients. Moreover, viral infections also constitute a serious problem for public health. Despite their efficacy, antiviral agents present several therapeutic limits. Accordingly, in the present work, we investigated the antitumor and antiviral activities of Orobanche crenata Forssk. (O. crenata), a parasitic plant, endemic to the Mediterranean basin, traditionally known for its beneficial properties for human health. Methods: The MTT assay was carried out to evaluate the cytotoxic effect of O. crenata leaf extract (OCLE) on human breast cancer cells (MCF-7 and MDA-MB-231) and the primary HFF-1 cell line. The lactic dehydrogenase (LDH) assay was performed on MCF-7 cells to analyze necrotic cell death. The antioxidant effect of OCLE was evaluated by intracellular determination of the reactive oxygen species and thiol groups, by DPPH and ABTS assays. The antiviral activity of OCLE was determined against Poliovirus 1, Echovirus 9, Human respiratory syncytial virus, Adenovirus type 2 and type 5, Coxsackievirus B1 (CoxB1) and B3 (CoxB3), Herpes simplex type 1 (HSV-1) and type 2 (HSV-2), and beta-Coronavirus by the plaque reduction assay. Results: The extract, after 24 h of incubation, did not affect MDA-MB-231 and HFF-1 cell viability. However, at the same time point, it showed a dose-dependent inhibitory effect on MCF-7 cells, with an increase in LDH release. OCLE exhibited free radical scavenging activity and significantly increased non-protein thiol levels in MCF-7 cells. OCLE effectively inhibited HSV-1, HSV-2, CoxB1, and CoxB3 replication. Conclusions: The overall results showed an interesting inhibitory effect of OCLE on both MCF-7 cell survival and viral replication.
C1 [Genovese, Carlo; Malaguarnera, Roberta] Kore Univ Enna, Fac Med & Surg, I-94100 Enna, Italy.
   [Genovese, Carlo; Nicolosi, Daria; Ronsisvalle, Simone; Acquaviva, Rosaria] Spin Off Univ Catania, Nacture Srl, I-95123 Catania, Italy.
   [Garozzo, Adriana] Univ Catania, Dept Biomed & Biotechnol Sci, Microbiol Sect, I-95123 Catania, Italy.
   [D'Angeli, Floriana; Guadagni, Fiorella] San Raffaele Roma Open Univ, Dept Human Sci & Qual Life Promot, I-00166 Rome, Italy.
   [Malfa, Giuseppe Antonio; Tomasello, Barbara; Acquaviva, Rosaria] Univ Catania, Dept Drug & Hlth Sci, Biochem Sect, I-95125 Catania, Italy.
   [Malfa, Giuseppe Antonio; Tomasello, Barbara; Acquaviva, Rosaria] Univ Catania, Res Ctr Nutraceut & Hlth Prod CERNUT, I-95125 Catania, Italy.
   [Bellia, Francesco] Natl Res Council CNR, Inst Crystallog, I-95126 Catania, Italy.
   [Nicolosi, Daria] Univ Catania, Dept Drug & Hlth Sci, Microbiol Sect, I-95125 Catania, Italy.
   [Ronsisvalle, Simone] Univ Catania, Dept Drug & Hlth Sci, Med Chem Sect, I-95125 Catania, Italy.
   [Guadagni, Fiorella] IRCCS San Raffaele Pisana, BioBIM Interinst Multidisciplinary Biobank, I-00166 Rome, Italy.
C3 Universita Kore di ENNA; University of Catania; University of Catania;
   University of Catania; Consiglio Nazionale delle Ricerche (CNR);
   Istituto Di Cristallografia (IC-CNR); University of Catania; University
   of Catania; IRCCS San Raffaele Pisana
RP D'Angeli, F (corresponding author), San Raffaele Roma Open Univ, Dept Human Sci & Qual Life Promot, I-00166 Rome, Italy.
EM carlo.genovese@unikore.it; agar@unict.it; floriana.dangeli@uniroma5.it;
   g.malfa@unict.it; francesco.bellia@cnr.it; btomase@unict.it;
   dnicolosi@unict.it; roberta.malaguarnera@unikore.it;
   s.ronsisvalle@unict.it; fiorella.guadagni@sanraffaele.it;
   racquavi@unict.it
RI Malfa, Giuseppe Antonio/AAG-4234-2020; Acquaviva, Rosaria/A-6750-2018;
   /AAU-5570-2020; Garozzo, Adriana/F-2855-2012; MALAGUARNERA,
   Roberta/K-8838-2016; GENOVESE, Carlo/D-7837-2012; Malfa, Giuseppe
   Antonio/AAG-4234-2020; /AAD-7995-2019; Bellia, Francesco/H-2812-2013;
   /AAR-9902-2020
OI Malfa, Giuseppe Antonio/0000-0002-6733-0587; Acquaviva,
   Rosaria/0000-0002-3139-1177; TOMASELLO, BARBARA/0000-0001-6049-942X;
   MALAGUARNERA, Roberta/0000-0003-4149-9488; GENOVESE,
   Carlo/0000-0003-2463-9047; Malfa, Giuseppe Antonio/0000-0002-6733-0587;
   Bellia, Francesco/0000-0002-9273-5949; 
FU European Social Fund [CUP G88I18000710007]
FX This work was partially supported by Grants from the European Social
   Fund PO FESR 2014-2020 Sicily Region Action 1.1.5, NUVACAL BC (CUP
   G88I18000710007).
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NR 116
TC 10
Z9 10
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD MAY
PY 2022
VL 11
IS 10
AR 1696
DI 10.3390/cells11101696
PG 19
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 1Q1YY
UT WOS:000802493200001
PM 35626733
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Tang, YL
   Pu, X
   Fan, ZL
   Kong, XY
   Zhang, C
   Li, LL
AF Tang, Yilian
   Pu, Xiang
   Fan, Zhiliang
   Kong, Xiangyan
   Zhang, Chen
   Li, Lailai
TI Mechanism of polygonum capitatum intervention in pulmonary nodule based
   on network pharmacology and molecular docking technology
SO MEDICINE
LA English
DT Article
DE molecular docking; network pharmacology; polygonum capitatum; pulmonary
   nodule
ID LIPID-METABOLISM; MIGRATION
AB The present study utilizes network pharmacology and molecular docking methodologies to investigate the mechanism of action behind the intervention of Polygonum capitatum Buch.-Ham.ex D. Don (THL) in treating pulmonary nodules (PN). This research aims to provide a theoretical foundation for broadening the clinical application of THL. Active components of THL were identified and screened through an extensive literature review and the PharmMapper database, followed by an analysis of their target interactions. Relevant targets associated with PN were selected using databases such as OMIM and GeneCards, with an intersection of the two sets being determined. STRING11.5 facilitated the acquisition of protein-protein interaction data, which was then imported into Cytoscape 3.7.2 to establish a protein interaction network topology. This enabled the identification of pivotal targets affected by THL intervention in PN. The study further employed the Metascape database to conduct GO and KEGG bioinformatics enrichment analyses, which illuminated core pathways involved in THL's therapeutic effects on PN. A comprehensive component-target-pathway diagram was constructed utilizing Cytoscape 3.7.2 software, with molecular docking validations carried out via Maestro software. A total of 49 active THL ingredients were discerned, implicating 67 PN-relevant targets. Subsequent software analysis pinpointed 10 key targets, including ALB, EGFR, and SRC. Molecular docking studies indicated strong binding affinities for most protein-compound pairs, with 44 out of 60 docking results exhibiting binding energies below -5 kcal/mol. Enrichment analysis highlights that key targets are mainly involved in pathways such as cancer, lipid metabolism and atherosclerosis, estrogen signaling, IL-17 signaling, complement and coagulation cascades, and chemical carcinogenesis through receptor activation. Through comprehensive network pharmacological approaches, this research delineates the synergy of THL's multiple components, targets, and pathways in mitigating PN. It posits that primary active ingredients of THL - quercetin, salidroside, and oleanolic acid - may exert effects on targets like ALB, EGFR, SRC, potentially modulating pathways associated with cancer, lipid and atherosclerosis, and IL-17 signaling in the context of PN intervention.
C1 [Tang, Yilian; Pu, Xiang; Fan, Zhiliang; Kong, Xiangyan; Zhang, Chen; Li, Lailai] Guizhou Univ Tradit Chinese Med, Guiyang 550025, Guizhou, Peoples R China.
   [Tang, Yilian] Zunyi Med & Pharmaceut Coll, Zunyi, Peoples R China.
C3 Guizhou University of Traditional Chinese Medicine
RP Li, LL (corresponding author), Guizhou Univ Tradit Chinese Med, Guiyang 550025, Guizhou, Peoples R China.
EM 690007324@qq.com; 314745595@qq.com; 103150868@qq.com; 840329848@qq.com;
   862636012@qq.com; 40482740@qq.com
FU National Natural Science Foundation of China [82060913]
FX This work was supported by National Natural Science Foundation of China
   (no. 82060913)
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NR 24
TC 2
Z9 2
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U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JUN 21
PY 2024
VL 103
IS 25
AR e38419
DI 10.1097/MD.0000000000038419
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA WA9I0
UT WOS:001252260600013
PM 38905418
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Li, ZH
   Li, JS
   Li, Y
   Guo, L
   Xu, PY
   Du, HQ
   Lin, N
   Xu, Y
AF Li, Zehui
   Li, Jiashan
   Li, Yuan
   Guo, Li
   Xu, Panyu
   Du, Hanqian
   Lin, Na
   Xu, Ying
TI The role of Cistanches Herba and its ingredients in improving
   reproductive outcomes: A comprehensive review
SO PHYTOMEDICINE
LA English
DT Review
DE Infertility; Cistanche tubulosa; Cistanche deserticola; Oxidative
   stress; Gonadal function; Phenylethanoid glycosides
ID OXIDATIVE STRESS; MALE-INFERTILITY; BETAINE; DAMAGE; CELLS;
   VERBASCOSIDE; ECHINACOSIDE; EXTRACT; OOCYTE; SUPPLEMENTATION
AB Background: Infertility patients account for an astonishing proportion of individuals worldwide. Due to its complex etiology and challenging treatment, infertility has imposed significant psychological and economic burdens on many patients. C. Herba (Cistanche tubulosa (Schenk) Wight and Cistanche deserticola Ma), renowned as one of the most prominent Chinese herbal medicines (CHMs), is abundant in diverse bioactive compounds that exhibit therapeutic effects on many diseases related to oxidative stress (OS) and disorders of sex hormone levels. Objective: Due to the limited drugs currently used in clinical practice to improve reproductive outcomes and their inevitable side effects, developing safe and effective new medications for infertility is of significance. This article comprehensively reviewed the phytochemicals of C. Herba, focusing on their efficacy and mechanisms on infertility and their safety for the first time, aiming to offer valuable insights for the development and application of C. Herba, and for developing novel strategies for treating infertility. Methods: We used "Cistanche" and its known bioactive components in combination with "sperm", "testicles", "epididymis", "ovaries", "uterus", and "infertility" as keywords to search in PubMed, Web of Science, Scopus and CNKI up to November 2023. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guideline was followed. Results: The therapeutic effects of C. Herba on infertility are mainly attributed to echinacoside (ECH), verbascoside (VB), salidroside (SAL), polysaccharides, and betaine. They can effectively improve spermatogenic dysfunction, gonadal dysfunction and erectile dysfunction (ED) by exerting anti-oxidation, sex hormones regulation and anti-hypoxia. Moreover, they can also improve premature ovarian failure (POF), ovarian and uterine cancer, oocyte maturation by exerting anti-oxidation, anti-apoptosis, and anti-cancer. C. Herba and its active ingredients also exhibit pleasing safety. Conclusion: C. Herba is a promising source of natural medicine for infertility. Additionally, compared to current therapeutic drugs, its favorable safety also supports its development as a nutritional supplement. However, highquality clinical studies are required to validate its effectiveness for the development of novel therapeutic strategies.
C1 [Li, Zehui; Li, Jiashan; Li, Yuan; Guo, Li; Xu, Panyu; Du, Hanqian; Lin, Na; Xu, Ying] China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China.
C3 China Academy of Chinese Medical Sciences; Institute of Chinese Materia
   Medica, CACMS
RP Xu, Y (corresponding author), China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China.
EM yxu@icmm.ac.cn
RI Guo, Li/GQP-3510-2022
FU Scientific and technological innovation project of China Academy of
   Chinese Medical Sciences [CI2023E001TS]; Beijing Natural Science
   Foundation [7242250]
FX This work was supported by Scientific and technological innovation
   project of China Academy of Chinese Medical Sciences (Grant Nos.
   CI2021A03802) , Beijing Natural Science Foundation (Grant Nos. 7242250)
   and Scientific and technological innovation project of China Academy of
   Chinese Medical Sciences (Grant Nos. CI2023E001TS) .
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NR 145
TC 26
Z9 29
U1 17
U2 95
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD JUL
PY 2024
VL 129
AR 155681
DI 10.1016/j.phymed.2024.155681
EA MAY 2024
PG 16
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA TB8A4
UT WOS:001238877200001
PM 38718638
DA 2026-05-27
ER

PT J
AU Dhar, P
   Das, SK
   Barhwal, K
   Hota, SK
   Mishra, KP
   Singh, SB
AF Dhar, Priyanka
   Das, Saroj Kumar
   Barhwal, Kalpana
   Hota, Sunil Kumar
   Mishra, Kamla Prasad
   Singh, Shashi Bala
TI Trans-Himalayan Phytococktail Confers Protection Against Hypobaric
   Hypoxia-Induced Hippocampal Neurodegeneration and Memory Impairment in
   Male Sprague Dawley Rats
SO HIGH ALTITUDE MEDICINE & BIOLOGY
LA English
DT Article
DE hypobaric hypoxia; neurodegeneration; neuroprotection; oxidative stress;
   phytococktail
ID HIPPOPHAE-RHAMNOIDES L.; OXIDATIVE STRESS; HIGH-ALTITUDE; EXPOSURE;
   MOOD; CA1; ENVIRONMENT; SALIDROSIDE; DIACETATE; RESPONSES
AB Background: Exposure to hypobaric hypoxia (HH) has been reported to cause neurodegeneration and memory impairment. Hippophae rhamnoides, Prunus armeniaca, and Rhodiola imbricata, the indigenous plants of Indian Trans-Himalaya are widely used in traditional Tibetan and Amchi system of medicine. These are rich sources of diverse bioactive metabolites having prophylactic and therapeutic uses against a wide array of neurodegenerative diseases. The objective of this study was to elucidate the prophylactic and neuroprotective efficacy of formulated phytococktail (PC) against simulated HH-induced neurodegeneration in male Sprague Dawley (SD) rats. Materials and Methods: A PC containing H. rhamnoides fruit pulp, P. armeniaca fruit pulp, and R. imbricata dry root extract (100:50:1) was formulated. The neuroprotective efficacy of PC was evaluated in male SD rats following exposure to 7 day HH at simulated altitude (25,000 ft, 282 mm Hg). Rats were divided into four groups viz., normoxia group (NOR), normoxic group treated with PC (NORPC), 7 day hypoxic group treated with vehicle (7DH), and 7 day hypoxic group treated with PC (7DHPC). Memory impairment and neuromorphological alterations were measured. Targeted protein expression was analyzed by immunoblotting study. Results: PC supplementation significantly reduced the oxidative stress markers during exposure to HH. Spatial memory impairment by HH was significantly ameliorated by PC. HH-induced augmented pyknosis, decreased dendritic arborization, and increased Hoechst-positive neurons in hippocampal CA3 region were significantly ameliorated by PC. Immunoblotting study showed upregulation of BDNF and TrkB expression by PC. PC also prevented the hippocampal neurodegeneration by activating the PI3K/AKT signaling pathway, which leads to GSK-3 beta inactivation by its phosphorylation and alleviation of hippocampal Caspase3 expression leading to inhibition of apoptotic neuronal cell death. Conclusion: The present study advocates the potential role of PC as an effective neuroprotective supplement in preventing HH-induced neurodegeneration. Activation of the PI3K/Akt pathway through BDNF/TrkB interaction following PC supplementation after exposure to HH inhibits hippocampal neuronal apoptosis and memory impairment.
C1 [Dhar, Priyanka; Das, Saroj Kumar; Barhwal, Kalpana; Hota, Sunil Kumar] Def Res & Dev Org, Def Inst High Altitude Res, Leh Ladakh, India.
   [Dhar, Priyanka] Techno India Univ, Dept Biotechnol, Salt Lake City, India.
   [Das, Saroj Kumar] Siksha O Anusandhan Deemed Univ, Ctr Biotechnol, Bhubaneswar, India.
   [Barhwal, Kalpana] All India Inst Med Sci, Bhubaneswar, India.
   [Mishra, Kamla Prasad; Singh, Shashi Bala] Def Res & Dev Org, Def Inst Physiol & Allied Sci, Timarpur, India.
   [Singh, Shashi Bala] Natl Inst Pharmaceut Educ & Res, Balanagar, India.
C3 Defence Research & Development Organisation (DRDO); Defence Institute of
   High Altitude Research (DIHAR); Siksha 'O' Anusandhan University; All
   India Institute of Medical Sciences (AIIMS) Bhubaneswar; Defence
   Research & Development Organisation (DRDO); Defence Institute of
   Physiology & Allied Sciences (DIPAS); National Institute of
   Pharmaceutical Education & Research, S.A.S. Nagar (Mohali)
RP Singh, SB (corresponding author), Natl Inst Pharmaceut Educ & Res, Hyderabad 500037, India.
EM drshashisingh@gmail.com
RI /AAS-9889-2021; Das, Saroj Kumar/W-5452-2019
OI Mishra, KP/0000-0002-8371-3772; Barhwal, Kalpana/0000-0001-7522-391X;
   Das, Saroj Kumar/0000-0002-5717-5333
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NR 62
TC 7
Z9 7
U1 0
U2 10
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1527-0297
EI 1557-8682
J9 HIGH ALT MED BIOL
JI High Alt. Med. Biol.
PD SEP 1
PY 2019
VL 20
IS 3
BP 279
EP 292
DI 10.1089/ham.2019.0011
PG 14
WC Biophysics; Public, Environmental & Occupational Health; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biophysics; Public, Environmental & Occupational Health; Sport Sciences
GA IZ8NZ
UT WOS:000487363700010
PM 31550185
DA 2026-05-27
ER

PT J
AU Li, SY
   Yang, CC
   Wang, WC
   Li, J
   Xu, SH
   Zhao, M
   Xu, CM
   Wang, JQ
   Wang, YJ
AF Li, Shuya
   Yang, Cuicui
   Wang, Weicong
   Li, Jian
   Xu, Shuhong
   Zhao, Min
   Xu, Chunmin
   Wang, Jiaqing
   Wang, Yongjun
TI First-in-human study to assess the safety, tolerability, and
   pharmacokinetics of intravenous SHPL-49 following single- and
   multiple-ascending-dose administration in healthy adults
SO JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
LA English
DT Article
DE SHPL-49; First-in-human; Pharmacokinetics; Tolerability; Neuroprotection
ID ISCHEMIC-STROKE
AB SHPL-49 is an innovative glycoside derivative that is synthesized by structural modifications of salidroside, demonstrating therapeutic effects on animal models of ischemia in pre-clinical experiments. A phase I, single- center, randomized, double-blind, placebo-controlled, single and multiple dose administration study of SHPL49 was conducted in healthy Chinese volunteers. In single-ascending-dose (SAD) study, 32 subjects randomized 6:2 to receive SHPL-49 (30 mg, 75 mg, 150 mg, 300 mg) or placebo with 30 minutes infusion. In multiple- ascending-dose (MAD) study, subjects were randomized 6:2 to receive SHPL-49 (75 mg, 150 mg, 300 mg) or placebo with 30 minutes infusion every 8 h for 7 days. Safety evaluations were conducted throughout the studies. Plasma and urine concentrations of SHPL-49 were detected and its metabolites were identified. Pharmacokinetic parameters were calculated using noncompartmental methods. SHPL-49 was generally safe and well-tolerated at single ascending doses (30-300 mg) and multiple ascending doses (75-300 mg). All adverse events were mild and resolved without any intervention. No serious adverse events were reported. In the SAD study, SHPL-49 exhibited dose-proportional plasma pharmacokinetics, with peak plasma concentration (Cmax) max ) ranging from 673.83 to 6275.00 ng/mL, area under the plasma concentration-time curve (AUC0-t) 0-t ) ranging from 338.57 to 3732.67 h & sdot;ng/mL, and elimination half-life (t1/2) 1/2 ) ranging from 0.49 to 0.67 h. In the MAD, the exposure was also dose-proportional and there was no significant accumulation following multiple dosing. Four metabolites were identified in urine and plasma. SHPL-49 shows a favorable pharmacokinetic, safety, and tolerability profile in healthy Chinese volunteers following a single- and multiple-ascending- dose administration in this study. For future therapeutic investigations, it is recommended to administer SHPL-49 intravenously at 8-hour intervals with a dosage range of 150-300 mg.
C1 [Li, Shuya; Wang, Yongjun] Capital Med Univ, Beijing Tiantan Hosp, Dept Clin Trial Ctr, Dept Neurol, Beijing, Peoples R China.
   [Li, Shuya; Wang, Yongjun] China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China.
   [Yang, Cuicui; Wang, Weicong; Li, Jian; Xu, Shuhong; Zhao, Min; Xu, Chunmin; Wang, Jiaqing] Capital Med Univ, Beijing Tiantan Hosp, Dept Clin Trial Ctr, Beijing, Peoples R China.
C3 Capital Medical University; Capital Medical University; Capital Medical
   University
RP Wang, YJ (corresponding author), Capital Med Univ, Beijing Tiantan Hosp, 119,South 4th Ring West Rd, Beijing 100070, Peoples R China.
EM shuyali85@163.com; ycctmg@126.com; wangweicong@bjtth.org;
   lijianjky@163.com; Beijing12223@163.com; zhaomin@bjtth.org;
   xcm36@sina.com; jiaqingwang2013@163.com; yongjunwang@ncrcnd.org.cn
RI wang, ying/L-2593-2018
FU Beijing Municipal Science & Tech-nology commission [Z221100007422050]
FX Funding This research was supported by Beijing Municipal Science
   & Tech-nology commission (No. Z221100007422050) .
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NR 24
TC 3
Z9 3
U1 1
U2 10
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0731-7085
EI 1873-264X
J9 J PHARMACEUT BIOMED
JI J. Pharm. Biomed. Anal.
PD OCT 15
PY 2024
VL 249
AR 116314
DI 10.1016/j.jpba.2024.116314
EA JUL 2024
PG 8
WC Chemistry, Analytical; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Pharmacology & Pharmacy
GA ZO8V2
UT WOS:001276339300001
PM 39033613
DA 2026-05-27
ER

PT J
AU Chen, BB
   Wei, JP
   Zhu, RY
   Zhang, H
   Xia, BK
   Liu, YG
   Dai, X
   Ye, ZMW
   Tian, YM
   Li, R
   Zhao, DD
   Mo, FF
   Orekhov, AN
   Gao, SH
   Brömme, D
   Wang, LL
   Zhang, DW
AF Chen, Beibei
   Wei, Junping
   Zhu, Ruyuan
   Zhang, Hao
   Xia, Bingke
   Liu, Yage
   Dai, Xuan
   Ye, Zimengwei
   Tian, Yimiao
   Li, Rui
   Zhao, Dandan
   Mo, Fangfang
   Orekhov, Alexander N.
   Gao, Sihua
   Bromme, Dieter
   Wang, Lili
   Zhang, Dongwei
TI Fructus Ligustri Lucidi aqueous extract promotes calcium balance and
   short-chain fatty acids production in ovariectomized rats
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Osteoporosis; Calcium balance; SCFAs; Fructus Ligustri Lucidi;
   Ovariectomized rats; Bone quality
ID GUT MICROBIOTA; GENE-EXPRESSION; ETHANOL EXTRACT; FEMALE RATS;
   ABSORPTION; SALIDROSIDE; METABOLISM; WOMEN; DIET
AB Ethnopharmacological relevance: Fructus Ligustri Lucidi (FLL) is an edible herb with anti-osteoporotic activity, yet whether and how the aqueous extract of this herb affect calcium metabolism in preservation of bone quality remain unclear. Aim of the study: To investigate the effects of FLL aqueous extract on calcium balance and short-chain fatty acids (SCFAs) production in ovariectomized (OVX) rats. Materials and methods: OVX rats were daily and orally administrated with FLL aqueous extract (3.5 g/kg) for 14 weeks. The levels of N-terminal propeptide of type I collagen (PINP) and C-terminal telopeptide of type I collagen (CTx-I) in rat serum were evaluated by ELISA assays. The concentration of calcium in serum, urine, and feces were determined by biochemical assays. Bone quality was determined by Micro-CT, a three-point bending assay, and Fourier Transform Infrared (FTIR) Spectrometry. The expressions of Calbindin D28K and Calcium-sensing receptor (CaSR) in kidney as well as the Vitamin D receptor (VDR), the transient receptor potential vanilloid receptor 6 (TRPV6), Calbindin D9k in the duodenum were measured by immunohistochemistry, western blotting, or real-time PCR. The short-chain fatty acids (SCFAs) levels in the feces of the cecum were tested by gas chromatograghy. Results: The administration of FLL to OVX rats resulted in a significant improvement in bone mineral density and biomechanical strength as well as in maintaining bone microstructures and material quality. Meanwhile, the decreased levels of PINP and increased levels of CTx-I in OVX rats were restored by FLL treatment. Additionally, FLL treatment increased calcium absorption, upregulated VDR, TRPV6, Calbindin D9k expressions in the duodenum, Calbindin D28K in kidney, and down-regulated CaSR expression in the kidney, as well as enhanced SCFAs levels in the feces of OVX rats. Conclusions: FLL aqueous extract may preserve bone quality through regulation of the calcium balance and intestinal SCFAs production in OVX rats. This offers translational value of FLL into osteoporosis clinical trial.
C1 [Chen, Beibei; Zhu, Ruyuan; Zhang, Hao; Xia, Bingke; Liu, Yage; Dai, Xuan; Ye, Zimengwei; Tian, Yimiao; Li, Rui; Zhao, Dandan; Mo, Fangfang; Gao, Sihua; Zhang, Dongwei] Beijing Univ Chinese Med, Tradit Chinese Med Sch, Diabet Res Ctr, Beijing 100029, Peoples R China.
   [Wei, Junping] China Acad Sci Tradit Chinese Med, Guanganmen Hosp, Beijing 100053, Peoples R China.
   [Orekhov, Alexander N.] Russian Acad Med Sci, Inst Gen Pathol & Pathophysiol, Lab Angiopathol, Moscow 125315, Russia.
   [Bromme, Dieter] Univ British Columbia, Fac Dent, Vancouver, BC V6T 1Z3, Canada.
   [Wang, Lili] Beijing Univ Chinese Med, Chinese Mat Med Sch, Dept TCM Pharmacol, Beijing 100029, Peoples R China.
C3 Beijing University of Chinese Medicine; Guang'anmen Hospital, CACMS;
   Russian Academy of Medical Sciences; Institute of General Pathology &
   Pathophysiology, RAMS; University of British Columbia; Beijing
   University of Chinese Medicine
RP Zhang, DW (corresponding author), Beijing Univ Chinese Med, Diabet Res Ctr, Beijing 100029, Peoples R China.; Wang, LL (corresponding author), Beijing Univ Chinese Med, Chinese Mat Med Sch, Beijing 100029, Peoples R China.
EM cbb8969@163.com; weijunping@126.com; zhuruyuan7@163.com;
   zhangxiaohaoxyz@163.com; xiabk1230@163.com; liuyage103@163.com;
   dx15077872512@163.com; yzmw1994@163.com; tymtianyimiao@126.com;
   bucmzhaodandan@163.com; xiaofang.tcm@163.com; a.h.opexob@gmail.com;
   gaosihua1216@163.com; dbromme@dentistry.ubc.ca; liliw0108@163.com;
   dongwei1006@gmail.com
RI Mo, Fangfang/LPQ-9010-2024; Zhang, Dongwei/AAS-8384-2020; ZHAO,
   DANDAN/JDD-3485-2023
FU National Natural Science Foundation of China (NSFC) [82074235,
   81874373]; Beijing Municipal Natural Science Foundation [7172126];
   Fundamental Research Funds for the Central Universities
   [2021JYBXJSJJ007]
FX This work was supported by the Grants from the National Natural Science
   Foundation of China (NSFC, Grant No. 82074235 and 81874373) and Beijing
   Municipal Natural Science Foundation (Grant No. 7172126) as well as the
   Fundamental Research Funds for the Central Universities (Grant No.
   2021JYBXJSJJ007) . The funding sources have no roles in study design,
   data analysis, drafting, and the submission the article.
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NR 46
TC 30
Z9 40
U1 4
U2 43
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
EI 1872-7573
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD OCT 28
PY 2021
VL 279
AR 114348
DI 10.1016/j.jep.2021.114348
EA JUN 2021
PG 11
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA UA4EZ
UT WOS:000685115400002
PM 34153448
DA 2026-05-27
ER

PT J
AU Sun, DC
   Li, XD
   Xu, SJ
   Cao, SX
   Quan, YS
   Cui, SB
   Xu, DY
AF Sun, Dingchun
   Li, Xiangdan
   Xu, Songji
   Cao, Shuxia
   Quan, Yingshi
   Cui, Songbiao
   Xu, Dongyuan
TI Dazhu Hongjingtian injection attenuated alcohol-induced depressive
   symptoms by inhibiting hippocampus oxidative stress and inflammation
   through Nrf2/HO-1/NLRP3 signaling pathway
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Alcohol; Depression; Hippocampus; Dazhu Hongjingtian injection;
   Nrf2/HO-1/NLRP3 signaling pathway
ID MAJOR DEPRESSION; SALIDROSIDE; REDUCTION; RHODIOLA; BEHAVIOR; TYROSOL;
   DISEASE; INJURY; DRUGS
AB Ethnopharmacological relevance: Alcoholic depression, a disorder of the central nervous system, is characterized by alcohol abuse, which causes blood-brain barrier disruption and oxidative damage in the brain. The rhizome of Rhodiola crenulate, from which Dazhu Hongjingtian Injection (DZHJTI) is derived, has been traditionally employed in ethnopharmacology to treat neurological disorders due to its neuroprotective, anti-inflammatory, and antioxidant properties. However, the exact mechanism by which DZHJTI alleviates alcoholic depression remains unclear. Aim of the study: This study aimed to investigate the antidepressant effects of DZHJTI and its underlying mechanisms in a mouse model of alcohol-induced depression. Materials and methods: A model of alcoholic depression was established using C57BL/6J mice, and the effects of DZHJTI on depression-like behaviors induced by alcohol exposure were assessed through behavioral experiments. Histopathological examination was conducted to observe nerve cell damage and microglial activation in the hippocampal region. Oxidative stress indices in the hippocampus, inflammatory factors, and serum levels of dopamine (DA) and 5-hydroxytryptamine (5-HT) were measured using ELISA. Expression of proteins related to the Nrf2/HO-1/NLRP3 signaling pathway was determined by Western blot analysis. Results: DZHJTI attenuated depression-like behaviors, neuronal cell damage, oxidative stress levels, inflammatory responses, and microglial activation. It also restored levels of brain-derived neurotrophic factor, brain myelin basic protein, DA, and 5-HT in mice with chronic alcohol exposure. After DZHJTI treatment, the expressions of Nuclear Respiratory Factor 2 (Nrf2) and Heme Oxygenase-1 (HO-1) increased in the hippocampus, whereas the levels of NOD-like receptor thermal protein domain-associated protein 3 (NLRP3), apoptosisassociated speck-like protein containing CARD, cleaved caspase-1, interleukin (IL)-1 beta, and IL-18 decreased. Conclusions: DZHJTI ameliorates alcohol-induced depressive symptoms in mice through its antioxidant and antiinflammatory effects, involving mechanisms associated with the Nrf2/HO-1/NLRP3 signaling pathway. This study highlights the potential of DZHJTI as a therapeutic option for alcohol-related depression and suggests the scope for future research to further elucidate its mechanisms and broader clinical applications.
C1 [Sun, Dingchun; Li, Xiangdan; Cao, Shuxia; Xu, Dongyuan] Yanbian Univ, Key Lab Cellular Funct & Pharmacol Jilin Prov, Yanji 133000, Jilin, Peoples R China.
   [Xu, Songji] Yanbian Univ, Sch Med, Dept Prevent Med, Yanji, Peoples R China.
   [Quan, Yingshi] Yanbian Univ Hosp, Dept Anesthesiol, Yanji, Jilin, Peoples R China.
   [Cui, Songbiao] Yanbian Univ Hosp, Dept Neurol, Yanji, Jilin, Peoples R China.
C3 Yanbian University; Yanbian University; Yanbian University; Yanbian
   University
RP Xu, DY (corresponding author), Yanbian Univ, Key Lab Cellular Funct & Pharmacol Jilin Prov, Yanji 133000, Jilin, Peoples R China.; Cui, SB (corresponding author), Yanbian Univ Hosp, Dept Neurol, Yanji, Jilin, Peoples R China.
EM sbcui@ybu.edu.cn; dyxu@ybu.edu.cn
RI sun, dingchun/KRQ-3045-2024
FU National Natural Science Foundation of China [82360479]; Natural Science
   Research Foundation of Jilin Province for Sciences and Technology
   [20220101355JC]
FX The authors declare that financial support was received for the
   research, authorship, and/or publication of this article. This study was
   supported by the National Natural Science Foundation of China (82360479,
   Xiangdan Li) and the Natural Science Research Foundation of Jilin
   Province for Sciences and Technology (20220101355JC DX) . We would like
   to thank Editage ( www.editage.cn) for English language editing.
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U1 2
U2 29
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
EI 1872-7573
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD NOV 15
PY 2024
VL 334
AR 118564
DI 10.1016/j.jep.2024.118564
EA JUL 2024
PG 13
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA YX6J3
UT WOS:001271821500001
PM 38996946
DA 2026-05-27
ER

PT J
AU Rungsimakan, S
   Rowan, MG
AF Rungsimakan, Supattra
   Rowan, Michael G.
TI Terpenoids, flavonoids and caffeic acid derivatives from Salvia
   viridis L. cvar. Blue Jeans
SO PHYTOCHEMISTRY
LA English
DT Article
DE Salvia viridis L.; Lamiaceae; Lupane; Triterpenoid; Diterpenoid;
   Abietane; Phenylpropanoid; Verbascoside; Flavonoid; Antibacterial
   activity
ID REARRANGED ABIETANE DITERPENES; PHENYLPROPANOID GLYCOSIDES;
   CONSTITUENTS; ROOTS; HORMINUM; TRITERPENOIDS; PLANTS
AB Three diterpenoids, 1-oxomicrostegiol (1), viroxocin (2), viridoquinone (3), were isolated from the roots of Salvia viridis L. cvar. Blue Jeans. Five known diterpenoids, microstegiol (4), 7 alpha-acetoxy-14-hydroxy-8,13-abietadiene-11,12-dione (5; 7-O-acetylhorminone tautomer), 7 alpha,14-dihydroni-8,13-abietadiene-11,12-dione (6; horminone tautomer), ferruginol and salvinolonyl 12-methyl ether (7) were also found in the roots together with 1-docosyl ferulate (8), and a mixture of 2-(4'-alkoxyphenyl) ethyl alkanoates (9). Two lupane triterpenoids, 2 alpha-acetoxy-lup-20(29)-en-3 beta-ol (10), and 3 beta-acetoxy-lup-20(29)-en-2 alpha-ol (11) were found in the aerial parts together with known compounds, lup-20(29)-ene-2 alpha,3 beta-diol (12), ursolic acid, oleanolic acid, beta-sitosterol and beta-sitosterol glucoside. A known phenylpropanoid, trans-verbascoside (or acteoside; 13), was the main constituent in the polar fraction of the aerial part, and it is now reported in the genus Salvia for the first time. Other polyphenolic compounds were cis-verbascoside (14), leucosceptoside A (15), martynoside (16), caffeic acid, 6-O-caffeoyl-glucose (18), rosmarinic acid, salidroside, luteolin-7-O-alpha-rhamnopyranosyl-(1 -> 6)-beta-galactopyranoside, luteolin-7-O-beta-galactopyranoside, luteolin-7-O-alpha-rhamnopyranosyl-(1 -> 6)-beta-glucopyranoside, luteolin-7-O-beta-glucopyranoside, and apigenin-7-O-alpha-glucopyranoside. The structures were determined by 1D-, 2D-NMR and HR-ESI-MS techniques. Compounds 6, 10, ferruginol, ursolic acid and oleanolic acid exhibited antibacterial activity against Entero coccus faecalis (ATCC 775) with MIC 50 mu M, 25 mu M, 50 mu M, 12.5 mu M, 12.5 mu M respectively. Ferruginol, ursolic acid and oleanolic acid were also active against Staphylococcus aureus (ATCC 6571), and Bacillus cereus (ATCC 2599) with MIC 12.5-50 mu M. 4 was also active against S. aureus (ATCC 6571) with MIC 50 mu M. These values are consistent with previous studies on the antimicrobial activity of Salvia diterpenoids. (c) 2014 Elsevier Ltd. All rights reserved.
C1 [Rungsimakan, Supattra] Mae Fah Luang Univ, Sch Sci, Chiang Rai 57100, Thailand.
   [Rowan, Michael G.] Univ Bath, Dept Pharm & Pharmacol, Bath BA2 7AY, Avon, England.
C3 Mae Fah Luang University; University of Bath
RP Rungsimakan, S (corresponding author), Mae Fah Luang Univ, Sch Sci, Chiang Rai 57100, Thailand.
EM rsupattra@outlook.com
FU Royal Thai government
FX The EPSRC National Mass Spectrometry Service Center, School of Medicine,
   University of Swansea is gratefully acknowledged for GC-CI-MS analysis.
   The authors would like to thank the Royal Thai government for granting a
   PhD studentship to SR.
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U1 1
U2 113
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9422
EI 1873-3700
J9 PHYTOCHEMISTRY
JI Phytochemistry
PD DEC
PY 2014
VL 108
BP 177
EP 188
DI 10.1016/j.phytochem.2014.08.029
PG 12
WC Biochemistry & Molecular Biology; Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Biochemistry & Molecular Biology; Plant Sciences
GA AY5FC
UT WOS:000347597400019
PM 25256822
DA 2026-05-27
ER

PT J
AU Moon, ES
   Lee, JY
   Kim, S
   Lee, SH
   Noh, HB
   Oh, S
   Choi, CW
   Jhun, HP
AF Moon, E. S.
   Lee, J. Y.
   Kim, S.
   Lee, S. H.
   Noh, H. B.
   Oh, S.
   Choi, C. W.
   Jhun, H. P.
TI Antioxidant and Anti-Inflammatory Activities of Ethanol Extract and its
   Fractions from Acer tegmentosum Stem
SO INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
LA English
DT Article
DE Acer tegmentosum stem; ethanol extract and its active fractions;
   anti-inflammatory activity; lipopolysaccharide-stimulated macrophages;
   high-performance liquid chromatography;
   2,2-diphenyl-1picryl-hydrazyl-hydrate 2,2
   '-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid
ID MEDICINAL-PLANTS; IN-VITRO; GENERATION; ACID
AB In this study, the first purpose was to determine total phenolic, total flavonoid and total terpenoid content of the Acer tegmentosum ethanol extract and four different types of fractions, including chloroform, ethyl acetate, n-butanol and water. Among the samples, Acer tegmentosum ethanol extract and fraction of ethyl acetate showed the highest total phenolic, total flavonoid and total terpenoid content. The second purpose was to evaluate the antioxidant activity of the samples assessed by in vitro methods such as scavenging capacity of 2,2-diphenyl-1-picryl-hydrazyl-hydrate and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid free radicals. Especially, Acer tegmentosum ethanol extract and fraction of ethyl acetate showed the strongest scavenging capacity with the lowest half maximal scavenging capacity values of these free radicals. The third purpose was to evaluate the anti-inflammatory activity in the lipopolysaccharide-stimulated Ralph and William's cell line 264.7 macrophages treated with various concentrations of Acer tegmentosum ethanol extract and fraction of ethyl acetate, and no cytotoxic effect on the macrophages was observed at the concentration of 100 mu g/ml of this extract. It suggested that this extract suppresses the activation of macrophages to secrete both pro-inflammatory cytokines (interleukin-1 beta, tumour necrosis factor alpha, inducible nitric oxide synthase and interleukin-6) and enzyme (inducible nitric oxide synthase) and anti-inflammatory cytokine (interleukin-10). The fourth purpose was to identify some compounds in a sample responsible for the antioxidant and anti-inflammation activities. In high-performance liquid chromatography chromatograms, the peak retention times detected from Acer tegmentosum ethanol extract and fraction of ethyl acetate in comparison with those from reference standards identified six compounds such as gallic acid, salidroside, (-)-epigallocatechin, (+)-catechin, scopoletin and trans-ferulic acid. It suggested that these compounds are responsible for antioxidant and anti-inflammation activities. Taken together, Acer tegmentosum seems to be one of the most promising species as a therapeutic source against diseases.
C1 [Moon, E. S.; Lee, J. Y.; Kim, S.; Lee, S. H.; Noh, H. B.; Oh, S.; Choi, C. W.] Pai Chai Univ, Dept Biol & Med Sci, Daejeon 35345, South Korea.
   [Jhun, H. P.] Daeduck Lab Co Ltd, Daejeon 34024, South Korea.
C3 Pai Chai University
RP Choi, CW (corresponding author), Pai Chai Univ, Dept Biol & Med Sci, Daejeon 35345, South Korea.
EM choicw@pcu.ac.kr
FU Ministry of Small and Medium-sized Enterprises (SMEs) and Startups
   (MSS), Korea, under the "Regional Specialized Industry Development Plus
   Program (RD) [S2894086]
FX This research was financially supported by the Ministry of Small and
   Medium-sized Enterprises (SMEs) and Startups (MSS), Korea, under the
   "Regional Specialized Industry Development Plus Program (R&D, S2894086)"
   supervised by the Korea Institute for Advancement of Technology (KIAT).
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NR 40
TC 0
Z9 0
U1 0
U2 36
PU INDIAN PHARMACEUTICAL ASSOC
PI MUMBAI
PA KALINA, SANTA CRUZ EAST, MUMBAI, 00000, INDIA
SN 0250-474X
EI 1998-3743
J9 INDIAN J PHARM SCI
JI Indian J. Pharm. Sci.
PY 2022
VL 84
SI 1
BP 52
EP 61
DI 10.36468/pharmaceutical-sciences.spl.412
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 0W6PZ
UT WOS:000789148100008
OA gold
DA 2026-05-27
ER

PT J
AU Li, N
   Luo, YQ
   Liu, XB
   Tan, DY
   Li, ZQ
AF Li, Na
   Luo, Yiqing
   Liu, Xuanbing
   Tan, Dayong
   Li, Zhanqiang
TI Rhodiola tangutica (maxim.) S. H. Fu protects
   blood-retinal barrier in hypoxia-induced retinal injury rats by
   down-regulating HIF-1α/eNOS/ NO pathway
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Rhodiola tangutica; High altitude retinopathy; Hypobaric hypoxia;
   Blood-retinal barrier; HIF-1 alpha/eNOS/NO
ID NITRIC-OXIDE; ANGIOGENESIS; MODELS
AB Ethnopharmacological relevance: Rhodiola tangutica (Maxim.) S. H. Fu (TS) (RT), as a traditional Tibetan medicine, has been used for treating acute and chronic mountain sickness in Qinghai Province of China for a long time. High altitude retinopathy (HAR), exposed to acute hypobaric hypoxia, is a retinal vascular endothelial dysfunction disease. Retinal vascular endothelial cells (ECs) play a significant role in inner blood-retinal barrier (iBRB) disruption. However, the effect and molecular mechanism of RT on iBRB dysfunction of HAR remains elusive. Aim of the study: Studies focusing on the pharmacological mechanism and effect of RT on acute hypobaric hypoxia-induced iBRB dysfunction. Materials and methods: In vivo, the rat models of acute hypobaric hypoxia-injured retina were established by simulating 5000 m altitude for 3 days. The animal models were administrated RT for 10 days. Retinal morphological changes, central retinal artery (CRA) hemodynamics, iBRB ultrastructure, retinal vascular leakage, nitric oxide (NO) generation, arginase activity assay, and the protein expression of HIF-1 alpha/eNOS pathway were measured. In vitro, 1 % O2-injured rat retinal microvascular endothelial cells (rRMECs) were used to detect RT effect on NO production and cell proliferation. The eNOS associated proteins were determined to explore underlying mechanism of RT by eNOS inhibitor L-NAME. Chemical profile of ethanol extract of RT was analyzed by ultra-high performance liquid chromatography with hybrid quadrupole-orbitrap mass spectrometry (UHPLC-Q-Exactive Orbitrap-MS). Results: RT increased CRA hemodynamic indices in the rat models of acute hypobaric hypoxia-injured retina. RT improved TJ length and lowered the percentage of swollen mitochondria in vascular endothelial ultrastructure of hypobaric hypoxia-injured retina. RT also ameliorated hypobaric hypoxia-induced retinal leakage by upregulating VE-cadherin and ZO-1 protein levels, and down-regulating HIF-1 alpha/eNOS/NO pathway. In addition, RT increased 1 % O2 -injured rRMECs viability by inhibiting eNOS/NO signaling. Salidroside is the main ingredient of RT. Conclusion: RT exerted protective effect on acute hypobaric hypoxia-induced iBRB dysfunction through suppressing HIF-1 alpha/eNOS/NO pathway.
C1 [Li, Na; Luo, Yiqing; Liu, Xuanbing] Qinghai Univ, Affiliated Hosp, Dept Ophthalmol, Xining 810001, Peoples R China.
   [Tan, Dayong] Qinghai Univ, Affiliated Hosp, Dept Gen Surg, Xining 810001, Peoples R China.
   [Li, Zhanqiang] Qinghai Univ, Lab High Altitude Med Qinghai Prov, Res Ctr High Altitude Med,Minist Educ, Key Lab High Altitude Med,Key Lab Applicat, Xining 810001, Peoples R China.
   [Li, Zhanqiang] Qinghai Univ, Fdn High Altitude Med Res Qinghai Prov, Qinghai Utah Joint Res Key Lab High Altitude Med, Xining 810001, Peoples R China.
C3 Qinghai University; Qinghai University; Qinghai University; Qinghai
   University
RP Tan, DY (corresponding author), Qinghai Univ, Affiliated Hosp, Dept Gen Surg, Xining 810001, Peoples R China.; Li, ZQ (corresponding author), Qinghai Univ, Res Ctr High Altitude Med, Xining 810001, Peoples R China.
EM 13519782135@163.com; zhanqiang_li@163.com
RI ; Tan, Dayong/H-4725-2011
OI LI, Zhanqiang/0000-0002-6482-3255; 
FU Science and Technology Plan Project Qinghai Province of China
   [2023-ZJ-768]; Qinghai Province "Kunlun Talents, High-end Innovative and
   Entrepreneurial Talents" Project
FX This work was funded by the Science and Technology Plan Project Qinghai
   Province of China (grant number 2023-ZJ-768) . Qinghai Province "Kunlun
   Talents, High-end Innovative and Entrepreneurial Talents" Project.
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NR 61
TC 2
Z9 2
U1 2
U2 7
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
EI 1872-7573
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD SEP 25
PY 2025
VL 353
AR 120325
DI 10.1016/j.jep.2025.120325
EA JUL 2025
PN A
PG 14
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA 7ZC9B
UT WOS:001583097600003
PM 40714061
DA 2026-05-27
ER

PT J
AU Li, XQ
   Chen, SP
   Shao, WH
   Wang, SX
   Yao, LX
AF Li, Xiuqin
   Chen, Shaopeng
   Shao, Weihua
   Wang, Suxing
   Yao, Lixia
TI Investigating the Effects and Mechanism of Rhodiola rosea
   Injection on Cardiac Function in Rats with Chronic Heart Failure
SO COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
LA English
DT Article
DE Rhodiola rosea injection; chronic heart failure; miRNA; RASS;
   traditional Chinese medication; echocardiographic index
ID MICRORNAS; PERFORMANCE; PROGRESSION
AB Aim To study the effect of Rhodiola rosea injection on cardiac function and the renin-angiotensin-aldosterone system (RASS) in rats with chronic heart failure. Background Rhodiola rosea injection, a traditional Chinese medication for relieving blood stasis and improving blood circulation, is an excellent therapeutic for treating coronary heart disease-angina pectoris. Rhodiola rosea injection's major component, salidroside, protects the cardiovascular system. But there isn't much first-hand evidence about how injectable Rhodiola rosea affects heart failure. Objectives In this study, a rat model of heart failure was established, and the effect of Rhodiola rosea injection on myocardial cell morphology, cardiac function, and ventricular remodelling in rats with heart failure was investigated. Methods 66 SD male rats were selected; 10 were randomly selected as a blank control group, and 56 were treated intraperitoneally with doxorubicin (4 g/g). After 6 weeks, all animals had LVEF 60%. Established a heart failure model. Each group had 14 rats: model control, low-dose, medium-dose, and high-dose Rhodiola rosea injection. The 2 mL/kg of Rhodiola rosea injection was injected into the tail vein once a day for 2 weeks. Both the blank and control groups received normal daily saline. After 2 weeks, the echocardiographic index, RASS-related index, and serum BNP level were assessed in all rats, and myocardial tissue morphology was observed. MiRNA423-5p, miRNA499-5p, and miRNA210-3p were extracted from peripheral blood. Rhodiola rosea injection on its expression was compared to healthy control rats. Results 6 mL/kg Rhodiola rosea injection lowered LVEDV and LVESV while increasing LVEF and LVFS. Injections of 6 mL/kg Rhodiola rosea reduce plasma levels of miR-210-3p, miR-423-5p, miRNA-499, and BNP in heart failure model rats. The 6 mL/kg Rhodiola rosea injection can restore the RASS indexes of heart failure rats to the level of the normal group. Conclusion The present study offers preliminary evidence supporting the use of Rhodiola rosea injection in the treatment of heart failure and offers a solid foundation for clinical off-label medication use.
C1 [Li, Xiuqin; Shao, Weihua; Wang, Suxing; Yao, Lixia] Hebei Gen Hosp, Dept Geriatr Cardiol, 348 Heping West Rd, Shijiazhuang 050050, Peoples R China.
   [Chen, Shaopeng] Hebei Gen Hosp, Dept Prevent Hlth, 348 Heping West Rd, Shijiazhuang 050050, Peoples R China.
RP Yao, LX (corresponding author), Hebei Gen Hosp, Dept Geriatr Cardiol, 348 Heping West Rd, Shijiazhuang 050050, Peoples R China.
EM yaolx2022@163.com
RI chen, shaopeng/MXK-6281-2025
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NR 41
TC 6
Z9 8
U1 1
U2 21
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1386-2073
EI 1875-5402
J9 COMB CHEM HIGH T SCR
JI Comb. Chem. High Throughput Screen
PY 2023
VL 26
IS 12
BP 2238
EP 2246
DI 10.2174/1386207326666230203145254
PG 9
WC Biochemical Research Methods; Chemistry, Applied; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Pharmacology & Pharmacy
GA M2SD5
UT WOS:001028721100011
PM 36740798
DA 2026-05-27
ER

PT J
AU Gu, JJ
   Zhang, LA
   You, J
   Zhan, JC
   Liang, H
   Gu, X
   Zhu, Y
AF Gu, Jianjun
   Zhang, Lina
   You, Jia
   Zhan, Jiacai
   Liang, Hao
   Gu, Xiang
   Zhu, Ye
TI Biomimetic nanoparticles functionalized by macrophage membrane
   ameliorate heart failure in mouse and human cardiac organoid model
SO CHEMICAL ENGINEERING JOURNAL
LA English
DT Article
DE Cardiac organoids; Heart failure; Myocardial infarction; Macrophage
   membranes; Biomimetic nanoparticles
ID OXIDATIVE STRESS; ATHEROSCLEROSIS; TARGET; CELL
AB Background: Heart failure (HF) remains one of the leading causes of morbidity and mortality worldwide, despite great advancements in therapeutic methods. The limitations of traditionally two-dimensional (2D) monolayer cell model makes it inappropriate for studying the physiology and pathology of huma heart. Three-D (3D) self- organizing structures like cardiac organoids (COs) can accurately mimic biological features and functions of heart tissues, and have therefore been widely used for drug cardiotoxicity testing and disease modeling. Recently, biomimetic nanoparticles derived from macrophage membranes (Mrp) are a promising delivery and therapeutic platform. Thus, this study aims to evaluate the therapeutic potential of biomimetic macrophage membranes nanoparticles in mouse and human cardiac organoid HF model. Methods: Human-induced pluripotent stem cells (hiPSCs) were used to generate self-organizing COs. Afterward, the COs were characterized by using inverted microscope, immunofluorescence, and hematoxylin and eosin (HE) staining. Later, biomimetic nanoparticles (Mrp- Salidroside (Active1)- NP and Mrp- hydroxysafflor yellow (HYSA, Active2)- NP) were fabricated by fusing the Mrp onto Active1 or Active2-loaded PLGA NP. Subsequently, the NPs were characterized using transmission electron microscopy (TEM), dynamic light scattering (DLS) and western blotting. Finally, in vitro and in vivo studies were performed to determine the therapeutic efficacy of Mrp-Active1-NP and Mrp-Active2-NP on HF, including histological analysis, echocardiograms, ELISA, quantitative real time polymerase chain reaction (qRT-PCR) and western blotting. Results: The TEM mapping and DLS analysis proved that nanoparticles of Mrp-Active1-NP and Mrp-Active2-NP had negative zeta potential and were spherically shaped and disguised by a cell membrane layer. In COs, Mrp-Active1NP and Mrp-Active2-NP significantly decreased doxorubicin-induced oxidative stress, inflammatory response, and cell apoptosis. Also, in vivo experiments showed that Mrp-Active1-NP and Mrp-Active2-NP markedly improved cardiac function, reversed myocardial structure, and attenuated myocardial apoptosis. These cardioprotective therapeutic effects were associated with the activation of Sirt1/Nrf2 signaling. Conclusion: In summary, our findings revealed that the Mrp-Active1-NP and Mrp-Active2-NP have significant therapeutic effect on HF, which suggests their potential as nano-delivery strategy for attenuation of HF.
C1 [Gu, Jianjun; Zhan, Jiacai; Liang, Hao] Yangzhou Univ, Northern Jiangsu Peoples Hosp, Dept Cardiol, Yangzhou, Jiangsu, Peoples R China.
   [Zhang, Lina] Nantong Univ, Dept Cardiol, Affiliated Hosp, 20 Xisi Rd, Nantong, Jiangsu, Peoples R China.
   [You, Jia] Yangzhou Maternal & Child Hlth Care Hosp, Dept Internal Med, Yangzhou 225001, Jiangsu, Peoples R China.
   [Gu, Xiang; Zhu, Ye] Northern Jiangsu Peoples Hosp, Dept Cardiol, 98 Nantong West Rd, Yangzhou, Jiangsu, Peoples R China.
C3 Yangzhou University; Nantong University
RP Zhu, Y (corresponding author), Northern Jiangsu Peoples Hosp, Dept Cardiol, 98 Nantong West Rd, Yangzhou, Jiangsu, Peoples R China.
EM 307971331@qq.com
FU National Natural Science Foundation of China [81800250]; China
   Postdoctoral Science Foundation [2022M711417]; Jiangsu Province
   Traditional Chinese Medicine Project [MS2023137]; Yangzhou Science and
   Technology Plan Social Development Project [YZ2023096]; Clinical Trials
   from the Northern Jiangsu People's Hospital [SBLC23002]
FX The following agencies supported this work namely National Natural
   Science Foundation of China (81800250) , China Postdoctoral Science
   Foundation (2022M711417) , Jiangsu Province Traditional Chinese Medicine
   Project (MS2023137) , Yangzhou Science and Technology Plan Social
   Development Project (YZ2023096) , Clinical Trials from the Northern
   Jiangsu People's Hospital (SBLC23002) .
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NR 42
TC 6
Z9 6
U1 10
U2 32
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 1385-8947
EI 1873-3212
J9 CHEM ENG J
JI Chem. Eng. J.
PD FEB 1
PY 2025
VL 505
AR 159447
DI 10.1016/j.cej.2025.159447
EA JAN 2025
PG 14
WC Engineering, Environmental; Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering
GA X0V7F
UT WOS:001422638600001
DA 2026-05-27
ER

PT J
AU Lu, KC
   Kuo, KL
   Wu, SC
   Lin, CH
   Lin, CJ
   Hou, YC
   Chen, JS
AF Lu, Kuo-Cheng
   Kuo, Ko-Lin
   Wu, San-Chiang
   Lin, Chih-Hui
   Lin, Cheng-Ju
   Hou, Yi-Chou
   Chen, Jin-Shuen
TI Therapeutic potential of Astragalus-based Eefooton in patients
   with chronic kidney disease: from clinical to bench study
SO INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
LA English
DT Article
DE Chronic kidney disease (CKD); Eefooton (EFT); estimated Glomerular
   Filtration Rate (eGFR); Fibrosis; poly-ADP-ribose polymerase-1(PARP-1);
   Traditional Chinese Medicine (TCM)
ID CODONOPSIS-PILOSULA; INJURY; MEMBRANACEUS; SALIDROSIDE; MEDICINE;
   GINSENG; END; L.
AB Objective: Chronic kidney disease (CKD) is a global health concern, and recent clinical evidence suggests the potential of traditional Chinese medicine (TCM) to slow CKD progression. This offers alternative strategies for CKD patients, mitigating risks related to polypharmacy and adverse drug reactions. Our self-controlled, prospective study aims to assess the impact of Eefooton (EFT), a TCM-based regimen, on kidney health in stage 3-5 CKD patients. Additionally, we conduct a cell culture study to explore the potential mechanisms of EFT in protecting renal function. Materials and methods: Between 2021 and 2022, 75 stage 3-5 CKD patients (56% males; mean age 68.20y) at Kaohsiung Veterans General Hospital and Wu San-Chiang Medical Clinic received six months of EFT treatment alongside conventional CKD medications. The primary outcome assessed was the change in estimated glomerular filtration rate (eGFR) at 6 months, with secondary outcomes including kidney size and blood biomarker changes. Adverse events were monitored. In an in vitro study, EFT effects on HK-2 cell viability and clonogenicity, as well as analysis of apoptosis and fibrosis-related proteins through Western blot, were investigated. Results: Median eGFR significantly improved from 34.37 +/- 13.58 to 42.47 +/- 18.82 mL/min/1.73 m(2) (p < 0.001) at month 6 post-treatment. Notably, improvements were observed across different baseline CKD stages (stage 3: p < 0.001, stage 4: p = 0.037). Ultrasonography scans indicated a slight increase in mean kidney size. In vitro, EFT enhanced HK-2 cell viability and increased clonogenicity. Indoxyl sulfate exposure raised cleaved and total PARP-1 activity. Co-treatment with EFT and IS reduced cleaved PARP-1 activity. EFT decreased IS-induced expression of fibrosis-related proteins (alpha-smooth muscle actin) without affecting apoptosis-related proteins (Caspase 3). Conclusions: When combined with conventional CKD medications, EFT has shown effectiveness in enhancing kidney function in individuals with stage 3-5 CKD, with no reported safety concerns. The PARP-1 inhibition and anti-fibrosis properties of EFT present potential benefits in the context of CKD.
C1 [Lu, Kuo-Cheng; Kuo, Ko-Lin] Taipei Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Dept Med, Div Nephrol, New Taipei City 231, Taiwan.
   [Lu, Kuo-Cheng] Fu Jen Catholic Univ, Fu Jen Catholic Univ Hosp, Sch Med, Dept Med,Div Nephrol, New Taipei City 243, Taiwan.
   [Wu, San-Chiang] Wu San Chiang Med Clin, 240Xianzheng Rd, Kaohsiung, Taiwan.
   [Lin, Chih-Hui; Lin, Cheng-Ju] Gerent Biotech R&D Ctr, Dept Pharm, 2 F,173,Sec 4,New Taipei Blvd, New Taipei City 242032, Taiwan.
   [Hou, Yi-Chou] Fu Jen Catholic Univ, Cardinal Tien Hosp, Sch Med, Dept Internal Med,Div Nephrol, New Taipei City 242, Taiwan.
   [Chen, Jin-Shuen] Chairman Int Affairs Comm, Kaohsiung Vet Gen Hosp Director, Dept Med Educ & Res, Taiwan Soc Nephrol, 386 Dazhong 1st Rd, Kaohsiung 813414, Taiwan.
C3 Buddhist Tzu Chi General Hospital; Taipei Tzu Chi Hospital; Fu Jen
   Catholic University; Fu Jen Catholic University Hospital; Fu Jen
   Catholic University; Cardinal Tien Hospital
RP Chen, JS (corresponding author), Chairman Int Affairs Comm, Kaohsiung Vet Gen Hosp Director, Dept Med Educ & Res, Taiwan Soc Nephrol, 386 Dazhong 1st Rd, Kaohsiung 813414, Taiwan.
EM jinshuen@yandex.com
RI Hou, Yi-Chou/AEE-2302-2022
OI Kuo, Ko-Lin/0000-0002-7477-0388
FU Teh-Tzer Study Group for Human Medical Research Foundation
   [TCRD-TPE-113-RT-3, (1/3)];  [B1121004]
FX The study was funded by the Taipei Tzu Chi Hospital (TCRD-TPE-113-RT-3
   (1/3) ) and the Teh-Tzer Study Group for Human Medical Research
   Foundation (B1121004).r Hospital (TCRD-TPE-113-RT-3 (1/3) ) and the
   Teh-Tzer Study Group for Human Medical Research Foundation (B1121004) .
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NR 60
TC 1
Z9 1
U1 0
U2 3
PU IVYSPRING INT PUBL
PI LAKE HAVEN
PA PO BOX 4546, LAKE HAVEN, NSW 2263, AUSTRALIA
SN 1449-1907
J9 INT J MED SCI
JI Int. J. Med. Sci.
PY 2025
VL 22
IS 1
BP 227
EP 239
DI 10.7150/ijms.102280
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA X0N5E
UT WOS:001422425100019
PM 39744164
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Wang, J
   Sun, ZX
   Tian, L
   Sun, W
   Wang, XN
   Wang, ZH
   Wang, ZY
   Li, Z
   Liu, W
   Ma, QC
   Ren, CY
   Gao, XN
   Li, Y
   Wang, LW
   Wang, XG
   Jiang, CJ
   Zhong, C
   Zhao, XH
   Yu, HQ
AF Wang, Jing
   Sun, Zexin
   Tian, Lei
   Sun, Wei
   Wang, Xinning
   Wang, Zhihao
   Wang, Zhiying
   Li, Zhao
   Liu, Wei
   Ma, Qianchi
   Ren, Chuanyou
   Gao, Xining
   Li, Yue
   Wang, Liwei
   Wang, Xiaoguang
   Jiang, Chunji
   Zhong, Chao
   Zhao, Xinhua
   Yu, Haiqiu
TI Transcriptome-metabolome and anatomy conjoint analysis of vital
   component change of photosynthesis in foxtail millet under different
   drought conditions
SO JOURNAL OF INTEGRATIVE AGRICULTURE
LA English
DT Article
DE foxtail millet; drought stress; RNA-seq; metabolites; photosynthesis
ID CHLOROPHYLL FLUORESCENCE PARAMETERS; MESOPHYLL CELL ULTRASTRUCTURE;
   PHOTOSYSTEM-II; SETARIA-ITALICA; LIGHT REACTIONS; WATER-STRESS; SALT
   STRESS; RNA-SEQ; TOLERANCE; ELECTRON
AB Drought caused by extreme climate change has become more severe and unpredictable, causing imperceptible effects on leaf photosynthesis in foxtail millet. To investigate the damage, we performed light drought (LD) and heavy drought (HD) treatments at both the elongation (Y) and booting stages to obtain a comprehensive understanding of the morphological, anatomical, physiological, transcriptome, and metabolome levels. Under drought stress, the length and area of leaves decreased, especially during the HD treatment at the booting stage. The number of mesophyll cells and the area of large vascular bundles decreased under LD and HD treatments at the booting stage, with more blurring vascular bundle structure and Kranz anatomy. However, these numbers decreased with no significance under Y-LD and Y-HD treatments at the elongation stage. The net photosynthetic rate, stomatal conductivity, transpiration rate, and intercellular CO2 concentration significantly decreased at the booting stage. In addition, the efficiency of electron transfers in photosystem II (PSII) decreased. Conjunction analyses of the transcriptome and metabolome were utilized to uncover the underlying mechanism at the booting stage. The results showed no common differentially enriched pathway in the transcriptome and metabolome under LD treatment. However, 32 pathways were enriched in both the transcript and metabolome under HD treatment. Among these, three pathways, including arginine and proline metabolism, tyrosine metabolism, and ubiquinone, along with other terpenoid-quinone biosynthesis pathways, were differentially enriched in both the transcript and metabolome. The accumulation of homogentisate, salidroside, homoprotocatechuate, L-DOPA, tyramine, and L-tyrosine increased under drought stress. Although genes related to PSII and the Calvin cycle were slightly up-regulated under LD conditions, they were down-regulated under HD conditions. The metabolites of ribose-5P, glycerate-3P, D-fructose-1, 6P2, and D-fructose-6P were all decreased in both the LD and HD treatments, especially D-fructose-6P, confirming that drought stress harmed the Calvin cycle. The results revealed that regardless of the severity of drought, the photosynthetic function was compromised not only at the morphological and anatomical levels but also in terms of impaired ATP synthase and inhibited photosynthetic CO2 assimilation.
C1 [Wang, Jing; Sun, Zexin; Wang, Xinning; Wang, Zhihao; Wang, Zhiying; Li, Zhao; Liu, Wei; Ma, Qianchi; Ren, Chuanyou; Gao, Xining; Li, Yue; Wang, Liwei; Wang, Xiaoguang; Jiang, Chunji; Zhong, Chao; Zhao, Xinhua; Yu, Haiqiu] Shenyang Agr Univ, Coll Agron, Shenyang 110866, Peoples R China.
   [Yu, Haiqiu] Liaoning Agr Vocat Tech Coll, Yingkou 115009, Peoples R China.
   [Tian, Lei; Sun, Wei] Linyi Acad Agr Sci, Linyi 276000, Peoples R China.
C3 Shenyang Agricultural University
RP Wang, J; Sun, ZX; Yu, HQ (corresponding author), Shenyang Agr Univ, Coll Agron, Shenyang 110866, Peoples R China.; Yu, HQ (corresponding author), Liaoning Agr Vocat Tech Coll, Yingkou 115009, Peoples R China.
EM yuhaiqiu@syau.edu.cn
RI 田, 磊/PHF-6008-2026; Ma, Qianchi/PJC-0510-2026
FU National Key Research and Development Program of China [2019YFD1002204];
   National Natural Science Foundation for Youth of China [31901505];
   Shenyang Agricultural University Introduced Talent Research Project,
   China [20153042]
FX This work was supported by the National Key Research and Development
   Program of China (2019YFD1002204) , the National Natural Science
   Foundation for Youth of China (31901505) , and the Shenyang Agricultural
   University Introduced Talent Research Project, China (20153042) .
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NR 125
TC 6
Z9 6
U1 16
U2 16
PU KEAI PUBLISHING LTD
PI BEIJING
PA 16 DONGHUANGCHENGGEN NORTH ST, Building 5, Room 411, BEIJING, DONGCHENG
   DISTRICT 100009, PEOPLES R CHINA
SN 2095-3119
EI 2352-3425
J9 J INTEGR AGR
JI J. Integr. Agric.
PD DEC
PY 2025
VL 24
IS 12
BP 4588
EP 4612
DI 10.1016/j.jia.2024.04.001
EA NOV 2025
PG 25
WC Agriculture, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture
GA D3536
UT WOS:001621447400001
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Adzika, GK
   Mprah, R
   Rizvi, R
   Adekunle, AO
   Noah, MLN
   Wowui, PI
   Adzraku, SY
   Adu-Amankwaah, J
   Wang, FL
   Lin, YW
   Fu, L
   Liu, XM
   Xiang, J
   Sun, H
AF Adzika, Gabriel Komla
   Mprah, Richard
   Rizvi, Ruqayya
   Adekunle, Adebayo Oluwafemi
   Ndzie Noah, Marie Louise
   Wowui, Prosperl Ivette
   Adzraku, Seyram Yao
   Adu-Amankwaah, Joseph
   Wang, Fengli
   Lin, Yuwen
   Fu, Lu
   Liu, Xiaomei
   Xiang, Jie
   Sun, Hong
TI Occlusion preconditioned mice are resilient to hypobaric hypoxia-induced
   myocarditis and arrhythmias due to enhanced immunomodulation, metabolic
   homeostasis, and antioxidants defense
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Article
DE hypobaric hypoxia; myocarditis; myocardial remodeling; arrhythmias;
   remote ischemic preconditioning; immunomodulation; metabolic
   homeostasis; antioxidant responses
ID ALTITUDE; DYSFUNCTION; MECHANISMS; INJURY
AB Background: Sea-level residents experience altitude sickness when they hike or visit altitudes above similar to 2,500 m due to the hypobaric hypoxia (HH) conditions at such places. HH has been shown to drive cardiac inflammation in both ventricles by inducing maladaptive metabolic reprogramming of macrophages, which evokes aggravated proinflammatory responses, promoting myocarditis, fibrotic remodeling, arrhythmias, heart failure, and sudden deaths. The use of salidroside or altitude preconditioning (AP) before visiting high altitudes has been extensively shown to exert cardioprotective effects. Even so, both therapeutic interventions have geographical limitations and/or are inaccessible/unavailable to the majority of the population as drawbacks. Meanwhile, occlusion preconditioning (OP) has been extensively demonstrated to prevent hypoxia-induced cardiomyocyte damage by triggering endogenous cardioprotective cascades to mitigate myocardial damage. Herein, with the notion that OP can be conveniently applied anywhere, we sought to explore it as an alternative therapeutic intervention for preventing HH-induced myocarditis, remodeling, and arrhythmias.
   Methods: OP intervention (6 cycles of 5 min occlusion with 200 mmHg for 5 min and 5 min reperfusion at 0 mmHg - applying to alternate hindlimb daily for 7 consecutive days) was performed, and its impact on cardiac electric activity, immunoregulation, myocardial remodeling, metabolic homeostasis, oxidative stress responses, and behavioral outcomes were assessed before and after exposure to HH in mice. In humans, before and after the application of OP intervention (6 cycles of 5 min occlusion with 130% of systolic pressure and 5 min reperfusion at 0 mmHg - applying to alternate upper limb daily for 6 consecutive days), all subjects were assessed by cardiopulmonary exercise testing (CPET).
   Results: Comparing the outcomes of OP to AP intervention, we observed that similar to the latter, OP preserved cardiac electric activity, mitigated maladaptive myocardial remodeling, induced adaptive immunomodulation and metabolic homeostasis in the heart, enhanced antioxidant defenses, and conferred resistance against HH-induce anxiety-related behavior. Additionally, OP enhanced respiratory and oxygen-carrying capacity, metabolic homeostasis, and endurance in humans.
   Conclusions: Overall, these findings demonstrate that OP is a potent alternative therapeutic intervention for preventing hypoxia-induced myocarditis, cardiac remodeling, arrhythmias, and cardiometabolic disorders and could potentially ameliorate the progression of other inflammatory, metabolic, and oxidative stress-related diseases.
C1 [Adzika, Gabriel Komla; Mprah, Richard; Adekunle, Adebayo Oluwafemi; Ndzie Noah, Marie Louise; Wowui, Prosperl Ivette; Adu-Amankwaah, Joseph; Fu, Lu; Sun, Hong] Xuzhou Med Univ, Dept Physiol, Xuzhou, Jiangsu, Peoples R China.
   [Rizvi, Ruqayya] Xuzhou Med Univ, Dept Clin Med, Xuzhou, Jiangsu, Peoples R China.
   [Adzraku, Seyram Yao] Xuzhou Med Univ, Dept Hematol, Key Lab Bone Marrow Stem Cell, Affiliated Hosp, Xuzhou, Peoples R China.
   [Wang, Fengli; Xiang, Jie] Xuzhou Med Univ, Affiliated Xuzhou Rehabil Hosp, Dept Rehabil Med, Xuzhou, Jiangsu, Peoples R China.
   [Lin, Yuwen] Xuzhou Med Univ, Jiangsu Key Lab New Drug Res & Clin Pharm, Xuzhou, Jiangsu, Peoples R China.
   [Liu, Xiaomei] Xuzhou Med Univ, Dept Pathogen Biol & Immunol, Jiangsu Key Lab Immun & Metab, Xuzhou, Jiangsu, Peoples R China.
   [Liu, Xiaomei] Xuzhou Med Univ, Lab Infect & Immun, Xuzhou, Jiangsu, Peoples R China.
C3 Xuzhou Medical University; Xuzhou Medical University; Xuzhou Medical
   University; Xuzhou Medical University; Xuzhou Medical University; Xuzhou
   Medical University; Xuzhou Medical University
RP Sun, H (corresponding author), Xuzhou Med Univ, Dept Physiol, Xuzhou, Jiangsu, Peoples R China.; Xiang, J (corresponding author), Xuzhou Med Univ, Affiliated Xuzhou Rehabil Hosp, Dept Rehabil Med, Xuzhou, Jiangsu, Peoples R China.
EM 18052268386@163.com; sunh@xzhmu.edu.cn
RI NDZIE NOAH, MARIE LOUISE/IST-0338-2023; Adu-Amankwaah,
   Joseph/ABE-2833-2021; Liu, Xiaomei/PKR-6131-2026; Adzika, Gabriel
   Komla/KIC-3860-2024; Mprah, Richard/AFC-7118-2022; ADEKUNLE, ADEBAYO
   OLUWAFEMI/AAO-3799-2021
OI NDZIE NOAH, MARIE LOUISE/0000-0003-3262-7556; Adzika, Gabriel
   Komla/0000-0002-4827-7266; Mprah, Richard/0000-0001-8762-5481; ADEKUNLE,
   ADEBAYO OLUWAFEMI/0000-0002-8590-1873; Wowui,
   Prosperl/0000-0003-4910-3046; Adzraku, Seyram Yao/0009-0005-6828-2627
FU National Natural Science Foundation of China [81971179]; Postgraduate
   Research & Practice Innovation Program of Jiangsu Province, China
   [KYCX17-1712]; Priority Academic Program Development of Jiangsu Higher
   Education Institutions (PAPD)
FX This research was supported by the National Natural Science Foundation
   of China (81971179) and the Postgraduate Research & Practice Innovation
   Program of Jiangsu Province, China (KYCX17-1712), and Priority Academic
   Program Development of Jiangsu Higher Education Institutions (PAPD).
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NR 49
TC 6
Z9 6
U1 0
U2 16
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD FEB 15
PY 2023
VL 14
AR 1124649
DI 10.3389/fimmu.2023.1124649
PG 14
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA 9K9FK
UT WOS:000941165600001
PM 36875113
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Yu, HC
   Lei, T
   Su, XJ
   Zhang, L
   Feng, ZZ
   Dong, MY
   Hou, ZY
   Guo, H
   Liu, J
AF Yu, Haichuan
   Lei, Ting
   Su, Xiaojie
   Zhang, Lu
   Feng, Zhouzhou
   Dong, Mengya
   Hou, Zheyu
   Guo, Hong
   Liu, Jian
TI Efficacy and safety of three species of Rhodiola L. in patients
   with chronic obstructive pulmonary disease: A systematic review and
   meta-analysis
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE Rhodiola L; chronic obstructive pulmonary disease; safety; efficacy;
   systematic review
ID MAJOR DEPRESSIVE DISORDER; CRENULATA; SALIDROSIDE; HYPERTENSION;
   SERTRALINE; ROSEA
AB Background: Chronic obstructive pulmonary disease (COPD) is characterized by chronic hypoxia, inflammation, oxidative stress, and irreversible airflow limitations. Rhodiola L. is a genus of botanical drugs used in traditional medicine that may influence COPD.Objective: A systematic review of the safety and efficacy of Rhodiola L. in patients with COPD.Material and methods: We searched the PubMed, Embase, Cochrane Library, Web of Science, Scopus, China National Knowledge Infrastructure (CNKI), Chongqing VIP, Wanfang, and SinoMed databases. The search strategy used terms including "COPD" and "Rhodiola." Two independent reviewers conducted the literature screening, data extraction, and risk of bias assessment, with a third reviewer involved to resolve disagreements. Statistical analysis was conducted in Review Manager (version 5.4.1), following the Cochrane Handbook.Results: This review included nine studies, of which two focused on Rhodiola crenulata (Hook.f. and Thomson) H. Ohba (R. crenulata) and two on Rhodiola kirilowii (Regel) Maxim (R. kirilowii); the remaining five focused on Rhodiola wallichiana (Hook.) S.H.Fu (R. wallichiana). Compared with the placebo, patients who received Rhodiola L. presented no more adverse events (p = 0.65) but showed significant improvement in the percentage of forced expiratory volume in 1 s at prediction (FEV1%pred), forced expiratory volume in 1 s (FEV1), the ratio of forced expiratory volume in 1 s on forced vital capacity (FEV1/FVC), saturation of oxygen in arterial blood, partial pressure of oxygen in arterial blood (PaO2), partial pressure of carbon dioxide in arterial blood (PaCO2), systolic pulmonary arterial pressure, diastolic pulmonary arterial pressure, COPD assessment test, efficient rate, C-reactive protein, and N-terminal pro-B-type natriuretic peptide (all p < 0.01). Compared with ambroxol, R. kirilowii provided additional benefits to patients with COPD in FEV1%pred, FEV1, FEV1/FVC, PaO2, PaCO2, 8-iso-prostaglandin F2a, superoxide dismutase, glutathione, malondialdehyde, and total antioxidant capacity (all p < 0.01).Conclusion: Among the Rhodiola L. genus, this review included R. wallichiana, R. crenulata, and R. kirilowii, which might be safe and effective in COPD. Although this study has several limitations, further RCTs are needed.
C1 [Yu, Haichuan; Lei, Ting; Su, Xiaojie; Zhang, Lu; Feng, Zhouzhou; Dong, Mengya; Hou, Zheyu; Guo, Hong; Liu, Jian] Lanzhou Univ, Med Coll 1, Clin Med Dept, Lanzhou, Peoples R China.
   [Yu, Haichuan; Lei, Ting; Su, Xiaojie; Zhang, Lu; Feng, Zhouzhou; Guo, Hong] Lanzhou Univ, Crit Care Dept, Hosp 1, Lanzhou, Peoples R China.
   [Liu, Jian] Gansu Prov Matern & Child Hlth Hosp, Gansu Prov Cent Hosp, Secretarys Off, Lanzhou, Peoples R China.
C3 Lanzhou University; Lanzhou University
RP Liu, J (corresponding author), Lanzhou Univ, Med Coll 1, Clin Med Dept, Lanzhou, Peoples R China.; Liu, J (corresponding author), Gansu Prov Matern & Child Hlth Hosp, Gansu Prov Cent Hosp, Secretarys Off, Lanzhou, Peoples R China.
EM medecinliu@sina.com
RI Lei, Ting/AAB-4274-2022
FU Science and Technology Projects of Gansu Province [18JR3RA344]; Special
   Funding for Big Data Research of Analgesic Sedation [Z-2019-1-002]
FX Funding This work was supported by the Science and Technology Projects
   of Gansu Province (Grant Number 18JR3RA344), and Special Funding for Big
   Data Research of Analgesic Sedation for Severe Infections. (Grant number
   Z-2019-1-002). Funders had no role in the design of the study, the
   collection and analysis of the data, or the preparation of the
   manuscript.
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NR 44
TC 3
Z9 4
U1 1
U2 13
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD APR 6
PY 2023
VL 14
AR 1139239
DI 10.3389/fphar.2023.1139239
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA F7ND4
UT WOS:000984165300001
PM 37089935
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zheng, JN
   Zhuo, JY
   Nie, J
   Liu, YL
   Chen, BY
   Wu, AZ
   Li, YC
AF Zheng, Jing-Na
   Zhuo, Jian-Yi
   Nie, Juan
   Liu, Yan-Lu
   Chen, Bao-Yi
   Wu, Ai-Zhi
   Li, Yu-Cui
TI Phenylethanoid Glycosides From Callicarpa kwangtungensis Chun Attenuate
   TNF-α-Induced Cell Damage by Inhibiting NF-κB Pathway and Enhancing Nrf2
   Pathway in A549 Cells
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE acute lung injury; callicarpa kwangtungensis chun; TNF-alpha; NF-kappa
   B; Nrf2
ID ACUTE LUNG INJURY; HEME OXYGENASE-1; IN-VIVO; INFLAMMATION; SALIDROSIDE;
   ACTIVATION; PREVENTION; RESOLUTION; INDUCTION
AB Background: Acute lung injury (ALI) is a complicated and severe lung disease, which is often characterized by acute inflammation. Poliumoside (POL), acteoside (ACT) and forsythiaside B (FTB) are phenylethanoid glycosides (PGs) with strong antioxidant, anti-inflammatory, and anti-apoptotic properties, which are extracted from Callicarpa kwangtungensis Chun (CK). The aim of this study was to investigate the protective effects of POL, ACT, and FTB against TNF-alpha-induced damage using an ALI cell model and explore their potential mechanisms.
   Methods and Results: MTT method was used to measure cell viability. Flow cytometry was used for detecting the apoptosis rate. Reactive oxygen species (ROS) activity was determined using fluorescence microscope. The expression of mRNA in apoptosis-related genes (Caspase 3, Caspase 8, and Caspase 9) were tested by qPCR. The effects of POL, ACT, FTB on the activities of nuclear factor erythroid-2 related factor 2 (Nrf2), nuclear factor kappa-B (NF-kappa B) and the expression of their downstream genes were assessed by western blotting and RT-PCR in A549 cells. In the current study, POL, ACT, and FTB dose-dependently attenuated TNF-alpha-induced IL-1 beta, IL-6 and IL-8 production, cell apoptosis, the expression of apoptosis-related genes (Caspase 3, Caspase 8, and Caspase 9) and ROS activity. POL, ACT, and FTB not only increased in the mRNA levels of antioxidative enzymes NADPH quinone oxidoreductase (NQO1), glutamate cysteine ligase catalytic subunit (GCLC), heme oxygenase (HO-1), but also decreased the mRNA levels of IL-1 beta, IL-6 and IL-8. Furthermore, they upregulated the expression of Keap1 and enhanced the activation of Nrf2, while decreased the expression of phosphor-I kappa B alpha (p-I kappa B alpha) and nuclear p65. In addition, no significant changes were observed in anti-inflammatory and antioxidant effects of POL, ACT, FTB following Nrf2 and NF-kappa B p65 knockdown.
   Conclusion: Our study revealed that POL, ACT, and FTB alleviated oxidative damage and lung inflammation of TNF-alpha-induced ALI cell model through regulating the Nrf2 and NF-kappa B pathways.
C1 [Zheng, Jing-Na; Nie, Juan; Liu, Yan-Lu; Chen, Bao-Yi; Wu, Ai-Zhi; Li, Yu-Cui] Guangzhou Univ Chinese Med, Sch Pharmaceut Sci, Guangzhou, Peoples R China.
   [Zhuo, Jian-Yi] Guangdong Pharmaceut Univ, Sch Clin Med, Affiliated Hosp 1, Dept Pharm, Guangzhou, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Guangdong Pharmaceutical
   University
RP Wu, AZ; Li, YC (corresponding author), Guangzhou Univ Chinese Med, Sch Pharmaceut Sci, Guangzhou, Peoples R China.
EM wuaizhi@gzucm.edu.cn; liyucui@gzucm.edu.cn
FU National Natural Science Foundation of China [82074082]; Pearl River S
   and T Nova Program of Guangzhou [201710010075]
FX This work was supported by the National Natural Science Foundation of
   China (82074082) and Pearl River S and T Nova Program of Guangzhou
   (201710010075).
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NR 39
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Z9 36
U1 3
U2 40
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD JUL 7
PY 2021
VL 12
AR 693983
DI 10.3389/fphar.2021.693983
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA TL6FA
UT WOS:000674953700001
PM 34305604
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhang, XX
   Wang, X
   Hu, XH
   Chu, XW
   Li, XT
   Han, F
AF Zhang Xiaoxue
   Wang Xue
   Hu Xinhua
   Chu Xiaowen
   Li Xintong
   Han Fei
TI Neuroprotective effects of a Rhodiola crenulata extract on
   amyloid-β peptides (Aβ1-42) -induced cognitive deficits in
   rat models of Alzheimer's disease
SO PHYTOMEDICINE
LA English
DT Article
DE Rhodiola crenulata; A beta(1-42); Intrahippocampal injection; Cognitive
   deficits; Alzheimer's disease
ID OXIDATIVE STRESS; CONSTITUENTS; SALIDROSIDE; SYSTEMS
AB Background: Rhodiola crenulata has been wildly used as a healthy food, antidepressant and antifatigue for many years in China. Recent studies suggested that Rhodiola crenulata extract (RCE) has cognitive protective effects in the treatment of Alzheimer's disease (AD).
   Purpose: To assess the protective effects of RCE on cognitive deficits and clarify its therapeutic mechanisms in A beta(1-42) -induced rat models of AD. Study design: RCE was prepared by freeze-drying technology. Their protective effects on A beta(1-42)-induced rat models of AD and the preliminary therapeutic mechanisms were studied.
   Methods: The Y maze test and Morris water maze (MWM) test were conducted to evaluate the learning and memory abilities of the rats. Subsequently, biochemical assays, hematoxylin-eosin staining, immunohistochemistry and Western blotting were performed to elucidate the mechanisms.
   Results: RCE significantly increased the spontaneous alternation (F (6, 111)=8.165, p< 0.001), prolonged the swimming time (F (6, 111)=20.143, p< 0.001) and decreased the escape latency in rat models of AD. In addition, RCE significantly increased the acetylcholine (Ach) level and the choline acetyl transferase (ChAT) activity (F (6, 34)=6.033, p< 0.001; F (6, 34)=6.958, p< 0.001, respectively), repaired the damage of hippocampus neurons and prevented A beta formation in the hippocampus in A beta(1-42) injected rats. Moreover, RCE increased the superoxide dismutase (SOD) activity and decreased the malondialdehyde (MDA) level in cortex of A beta(1-42) injected rats (F (6, 34)=5.097, p< 0.01; F (6, 34)=2.907, p< 0.05, respectively), significantly reduced the expressions of p-tau (ser396) and induced the expressions of p-GSK3 beta (ser9) in hippocampus (F (6, 34)=15.297, p< 0.001; F (6, 34)=9.652, p< 0.001, respectively).
   Conclusion: Our findings demonstrated that RCE significantly alleviated the learning and memory deficits in the A beta(1-42)-induced rat models of AD. The mechanisms involved its protection effects against cholinergic system deficiency, oxidative stress damage and GSK3 beta activation. RCE may be a potential therapeutic medicine with multi-targets to prevent the progression of cognitive deterioration in AD.
C1 [Zhang Xiaoxue; Wang Xue; Chu Xiaowen; Li Xintong; Han Fei] Shenyang Pharmaceut Univ, Sch Pharm, 103 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China.
   [Hu Xinhua] Shenyang Pharmaceut Univ, Sch Life Sci & Biopharmaceut, 103 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China.
   [Han Fei] Liaoning Univ Tradit Chinese Med, Key Lab, Minist Educ TCM Viscera State Theory & Applicat, 79 Chongshan Eastern Rd, Shenyang 110016, Liaoning, Peoples R China.
C3 Shenyang Pharmaceutical University; Shenyang Pharmaceutical University;
   Liaoning University of Traditional Chinese Medicine
RP Han, F (corresponding author), Shenyang Pharmaceut Univ, Sch Pharm, 103 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China.
EM hanfei_spu@163.com
FU National Natural Science Foundation of China [81673573]; Open fund of
   Key Laboratory of Ministry of Education for TCM Viscera-State Theory and
   Applications, Liaoning University of Traditional Chinese Medicine
   [zyzx1707]
FX This work was supported by the National Natural Science Foundation of
   China (no. 81673573) and the Open fund of Key Laboratory of Ministry of
   Education for TCM Viscera-State Theory and Applications, Liaoning
   University of Traditional Chinese Medicine (no. zyzx1707).
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NR 28
TC 36
Z9 43
U1 1
U2 48
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD APR
PY 2019
VL 57
BP 331
EP 338
DI 10.1016/j.phymed.2018.12.042
PG 8
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA HU2DO
UT WOS:000465081700034
PM 30807987
DA 2026-05-27
ER

PT J
AU Zhang, X
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   Liang, FH
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AF Zhang, Xue
   He, Dan
   Jia, Jialin
   Liang, Feihong
   Mei, Jie
   Li, Wenhua
   Liu, Tingting
   Wang, Zhiyu
   Liu, Yu
   Zhang, Fengxue
   Zhang, Zhiren
   Luo, Bangwei
TI Erythropoietin mediates re-programming of endotoxin-tolerant macrophages
   through PI3K/AKT signaling and protects mice against secondary infection
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Article
DE endotoxin tolerance; sepsis; macrophages; HIF-1 alpha; erythropoietin
ID ENDOTHELIAL GROWTH-FACTOR; BACTERIAL CLEARANCE; PI3K-AKT PATHWAY;
   IRAK-M; RECEPTOR; LIPOPOLYSACCHARIDE; PHAGOCYTOSIS; INFLAMMATION;
   SALIDROSIDE; ACTIVATION
AB Initial lipopolysaccharide (LPS) exposure leads to a hypo-responsive state by macrophages to a secondary stimulation of LPS, known as endotoxin tolerance. However, recent findings show that functions of endotoxintolerant macrophages are not completely suppressed, whereas they undergo a functional re-programming process with upregulation of a panel of molecules leading to enhanced protective functions including antimicrobial and tissue-remodeling activities. However, the underlying molecular mechanisms are still elusive. Erythropoietin (EPO), a glycoprotein regulated by hypoxia-inducible factor 1 alpha (HIF-1 alpha), exerts anti-inflammatory and tissue-protective activities. Nevertheless, the potential effects of EPO on functional re-programming of endotoxin-tolerant macrophages have not been investigated yet. Here, we found that initial LPS exposure led to upregulation of HIF-1 alpha/EPO in macrophages and that EPO enhanced tolerance in tolerized macrophages and mice as demonstrated by suppressed proinflammatory genes such as IL1b, IL6, and Tnfa after secondary LPS stimulation. Moreover, we showed that EPO improved host protective genes in endotoxin-tolerant macrophages and mice, such as the anti-bacterial genes coding for cathelicidin-related antimicrobial peptide (Cnlp) and macrophage receptor with collagenous structure (Marco), and the tissue-repairing gene vascular endothelial growth factor C (Vegfc). Therefore, our findings indicate that EPO mediates the functional re-programming of endotoxin-tolerant macrophages. Mechanistically, we found that PI3K/AKT signaling contributed to EPO-mediated re-programming through upregulation of Irak3 and Wdr5 expression. Specifically, IL-1 receptor-associated kinase 3 (IRAK3) was responsible for inhibiting proinflammatory genes IL1b, Il6, and Tnfa in tolerized macrophages after LPS rechallenge, whereas WDR5 contributed to the upregulation of host beneficial genes including Cnlp, Marco, and Vegfc. In a septic model of mice, EPO pretreatment significantly promoted endotoxin-tolerant re-programming, alleviated lung injury, enhanced bacterial clearance, and decreased mortality in LPS-tolerized mice after secondary infection of Escherichia coli. Collectively, our results reveal a novel role for EPO in mediating functional re-programming of endotoxin-tolerant macrophages; thus, targeting EPO appears to be a new therapeutic option in sepsis and other inflammatory disorders.
C1 [Zhang, Xue; Mei, Jie; Li, Wenhua; Zhang, Fengxue] Guangzhou Univ Chinese Med, Sch Basic Med Sci, Res Ctr Integrat Med, Guangzhou, Peoples R China.
   [He, Dan; Jia, Jialin] Chongqing Univ, Coll Med, Chongqing, Peoples R China.
   [Liang, Feihong] Shunde Polytechn, Dept Med Sci, Foshan, Peoples R China.
   [Liu, Tingting; Wang, Zhiyu; Liu, Yu; Zhang, Zhiren; Luo, Bangwei] Army Med Univ, Inst Immunol, Chongqing, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Chongqing University; Army
   Medical University
RP Zhang, FX (corresponding author), Guangzhou Univ Chinese Med, Sch Basic Med Sci, Res Ctr Integrat Med, Guangzhou, Peoples R China.; Zhang, ZR; Luo, BW (corresponding author), Army Med Univ, Inst Immunol, Chongqing, Peoples R China.
EM zhangfengxue@gzucm.edu.cn; zhangzhiren@tmmu.edu.cn;
   bangwei_luo@outlook.com
RI wang, zhiyu/K-5255-2016; zhang, zhiren/I-1046-2014
FU National Natural Science Foundation of China [32000638, 82071778]
FX This work was supported by grants (32000638 and 82071778) from the
   National Natural Science Foundation of China (BL and ZZ).
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NR 56
TC 10
Z9 12
U1 2
U2 17
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD AUG 9
PY 2022
VL 13
AR 938944
DI 10.3389/fimmu.2022.938944
PG 14
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA 6A1RE
UT WOS:000880437600001
PM 36016936
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Cao, SH
   Xue, JX
   Chen, L
   Hao, Y
   Lu, MJ
   Feng, M
   Wang, HH
   Zhou, J
   Yao, C
AF Cao, Sihan
   Xue, Jingxian
   Chen, Lu
   Hao, Yun
   Lu, Meijuan
   Feng, Ming
   Wang, Huanhuan
   Zhou, Jun
   Yao, Chang
TI Effects of the Chinese herbal medicine Hong Huang decoction, on
   myocardial injury in breast cancer patients who underwent
   anthracycline-based chemotherapy
SO FRONTIERS IN CARDIOVASCULAR MEDICINE
LA English
DT Article
DE breast cancer; chemotherapy; anthracycline; Hong Huang decoction; GLS
ID INDUCED CARDIOTOXICITY; OXIDATIVE STRESS; HEART-FAILURE;
   ECHOCARDIOGRAPHY; SALIDROSIDE; DYSFUNCTION; ACTIVATION; STRAIN
AB ObjectiveTo assess the effects of Hong Huang Decoction (HHD), a Chinese herbal medicine, on myocardial injury in breast cancer patients who underwent anthracycline (ANT)-based chemotherapy. MethodsA total of 51 patients with breast cancer who underwent an ANT-based chemotherapy program and met the inclusion/exclusion criteria were allocated to the treatment or placebo groups using a random number generation process. Patients in the treatment group received liquid HHD twice a day. Treatment was given from 1 day prior to chemotherapy up to the end of chemotherapy (after 6 months). Participants in the placebo group received a placebo over the same schedule. Left ventricular ejection fraction (LVEF), global longitudinal strain (GLS), diagnostic markers of acute myocardial infarction [e.g., lactate dehydrogenase (LDH), creatine kinase-MB (CK-MB), and B-type natriuretic peptide (BNP)], nitric oxide (NO), superoxide dismutase (SOD), as well as pro-inflammatory cytokines [e.g., tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and human C-reactive protein (CRP)], and anti-inflammatory cytokine interleukin-10 (IL-10), were outcome measures assessed before chemotherapy, 3 and 6 months after chemotherapy. ResultsCompared to the placebo group, the GLS value was significantly higher in the treatment group (19.95 +/- 1.16 vs. 19.06 +/- 1.64, P <= 0.001). Significant differences were also noted for levels of SOD (689.71 +/- 203.60 vs. 807.88 +/- 182.10, P < 0.05), IL-6 (58.04 +/- 22.06 vs. 194.20 +/- 40.14, P <= 0.001), IL-10 (237.90 +/- 94.98 vs. 68.81 +/- 32.92, P <= 0.001), NO (75.05 +/- 26.39 vs. 55.83 +/- 19.37, P <= 0.005), and TNF-alpha (301.80 +/- 134.20 vs. 680.30 +/- 199.60, P <= 0.001) in the patients before chemotherapy compared to 6 months after initiating chemotherapy. ConclusionHHD regulated the levels of IL-6, IL-10, SOD, NO, and TNF-alpha. The results demonstrated that GLS is a better indicator of early myocardial injury compared to LVEF, and HHD could modulate oxidative stress to protect against ANT cardio toxicity.
C1 [Cao, Sihan; Xue, Jingxian; Chen, Lu; Hao, Yun; Feng, Ming; Wang, Huanhuan; Zhou, Jun; Yao, Chang] Nanjing Univ Chinese Med, Dept Breast Dis, Aliated Hosp, Nanjing, Peoples R China.
   [Cao, Sihan; Chen, Lu; Hao, Yun; Feng, Ming; Wang, Huanhuan] Nanjing Univ Chinese Med, Clin Coll 1, Nanjing, Peoples R China.
   [Lu, Meijuan] Nanjing Univ Chinese Med, Dept Echocardiog, Aliated Hosp, Nanjing, Peoples R China.
C3 Nanjing University of Chinese Medicine; Nanjing University of Chinese
   Medicine; Nanjing University of Chinese Medicine
RP Yao, C (corresponding author), Nanjing Univ Chinese Med, Dept Breast Dis, Aliated Hosp, Nanjing, Peoples R China.
EM yaochang67@126.com
RI xue, jingxian/OZD-9357-2025
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NR 50
TC 3
Z9 3
U1 0
U2 16
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2297-055X
J9 FRONT CARDIOVASC MED
JI Front. Cardiovasc. Med.
PD JUL 22
PY 2022
VL 9
AR 921753
DI 10.3389/fcvm.2022.921753
PG 12
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 3O8KW
UT WOS:000837084600001
PM 35935647
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Lu, BY
   Li, MQ
   Zhou, F
   Huang, WS
   Jiang, YR
   Mao, SQ
   Zhao, YJ
   Lou, TT
AF Lu, Baiyi
   Li, Maiquan
   Zhou, Fei
   Huang, Weisu
   Jiang, Yirong
   Mao, Shuqin
   Zhao, Yajing
   Lou, Tiantian
TI The Osmanthus fragrans flower phenylethanoid glycoside-rich
   extract: Acute and subchronic toxicity studies
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE OFFE; Phenylethanoid glycoside; Acteoside; Acute toxicity sudy;
   Subchronic toxicity study; Nontoxic
ID MELANOGENESIS; ACTEOSIDE
AB Ethnopharmacological relevance: Osmanthus fragrans var. thunbergii (O. fragrans) flower has been consumed as folk medicine for thousands of years. O. fragrans flower extract is a well-characterized phenylethanoid glycoside-rich extract, which has been used as a natural anti-oxidant. The aim of this study was to evaluate the safety of O. fragrans flower phenylethanoid glycoside-rich extract (OFFE).
   Materials and methods: The OFFE was extracted by 80% (v/v) aqueous ethanol with 0.01% sodium isoascorbate (w/v) from the O. fragrans flower and purified on HPD300 resins. The total phenylethanoid glycosides content and individual phenylethanoid glycosides was determined by photocolorimetric method and reversed phase UPLC respectively. An acute oral toxicity study, reverse mutation test, bone marrow cell micronucleus test, and sperm abnormality test as well as a 90-day oral toxicity study were performed on experimental animals.
   Results: The total content of phenylethanoid glycosides in OFFE was 73.4 g acteoside equivalent per 100 g of extract, include acteoside (52.5 g per 100 g of extract), salidroside (13.8 g per 100 g of extract), and isoacteoside (2.6 g per 100 g of extract) and so on. No acute lethal effect at the maximal tested OFFE dose of 10 g/kg body weight (bw) in either rats or mice was observed, suggesting that OFFE can be considered nontoxic. No evidence for mutagenicity was detected in any of the three mutagenic tests. Administration at levels of 0.50, 1.00, and 2.00 g/kg bw to rats for 90 days failed to induce any significant hematological, clinical, chemical, or histopathological changes. The no-observed adverse-effect-level for OFFE was > 2.00 g/kg bw for the study on subchronic toxicity.
   Conclusion: The results showed that consuming OFFE has no adverse effects and poses no health risk in the acute oral toxicity study, subchronic oral toxicity study, and in the micronucleus test, which may provide supportive evidence for the safety of OFFE powder that has been used in medicine as well as in functional foods, and dietary supplements. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
C1 [Lu, Baiyi; Li, Maiquan; Zhou, Fei; Jiang, Yirong; Mao, Shuqin; Zhao, Yajing; Lou, Tiantian] Zhejiang Univ, Coll Biosyst Engn & Food Sci, Zhejiang R&D Ctr Food Technol & Equipment, Fuli Inst Food Sci,Zhejiang Key Lab Agrofood Proc, Hangzhou 310058, Zhejiang, Peoples R China.
   [Lu, Baiyi; Li, Maiquan; Zhou, Fei; Jiang, Yirong; Mao, Shuqin; Zhao, Yajing; Lou, Tiantian] Minstry Agr, Lab Qual & Safety Risk Assessment Agroprod Storag, Hangzhou 310058, Zhejiang, Peoples R China.
   [Huang, Weisu] Zhejiang Econ & Trade Polytech, Dept Appl Technol, Hangzhou 310018, Peoples R China.
C3 Zhejiang University
RP Lu, BY (corresponding author), Zhejiang Univ, Coll Biosyst Engn & Food Sci, Hangzhou 310003, Zhejiang, Peoples R China.
EM bylu@zju.edu.cn
RI ; Yang, Bowen/KWV-0501-2024
OI Jiang, Yirong/0000-0001-7070-4909; 
FU Zhejiang Provincial Natural Science Foundation of China [R15C200002];
   Special Project of Agricultural Product Quality Safety Risk Assessment,
   Ministry of Agriculture, China [GJFP2016015]
FX This work was supported financially by the Zhejiang Provincial Natural
   Science Foundation of China (No. R15C200002) and the Special Project of
   Agricultural Product Quality Safety Risk Assessment (No. GJFP2016015),
   Ministry of Agriculture, China.
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NR 24
TC 20
Z9 27
U1 1
U2 51
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
EI 1872-7573
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD JUL 1
PY 2016
VL 187
BP 205
EP 212
DI 10.1016/j.jep.2016.04.049
PG 8
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA DP0OZ
UT WOS:000378190400020
PM 27130643
DA 2026-05-27
ER

PT J
AU Elgendy, SA
   Soliman, MM
   Shukry, M
   Mohammed, LA
   Nasr, HE
   Althobaiti, S
   Almalki, DA
   Alotaibi, KS
   Albattal, SB
   Elnoury, HA
AF Elgendy, Salwa A.
   Soliman, Mohamed Mohamed
   Shukry, Mustafa
   Mohammed, Lina Abdelhady
   Nasr, Hend Elsayed
   Althobaiti, Saad
   Almalki, Daklallah A.
   Alotaibi, Khalid S.
   Albattal, Shatha B.
   Elnoury, Heba A.
TI Screening impacts of Tilmicosin-induced hepatic and renal toxicity in
   rats: protection by Rhodiola rosea extract through the involvement of
   oxidative stress, antioxidants, and inflammatory cytokines biomarkers
   (Publication with Expression of Concern. See OCT, 2025)
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Article; Publication with Expression of Concern
DE Hepato-renal dysfunction; Tilmicosin; Rhodiola rosea; Protection; Gene
   expression; Oxidative stress
ID INTERMEDIATE-FILAMENTS; INDUCED CARDIOTOXICITY; L-CARNITINE; L. EXTRACT;
   SALIDROSIDE; PROTEIN; CELLS; ALPHA; PROGRESSION; INFECTIONS
AB Tilmicosin (TIL) is a semisynthetic macrolide antibiotic with a broad spectrum of activity derived from tylosin. TIL is effective in the treatment of bovine and ovine respiratory diseases caused by different microbes. In parallel, Rhodiola rosea (RHO) is a popular herbal remedy because of its anti-inflammatory and antioxidant qualities. The experiment lasted for 12 days. Depending on the experimental group, the animals received either distilled water or RHO root extract dissolved in distilled water for 12 days through a stomach tube, and the single subcutaneous injection on day 6 of the experiment of either 500 mu L of 0.9% NaCl or TIL dissolved in 500 mu L 0.9% NaCl. Samples and blood were collected for serum analysis, gene expression, and immunohistochemistry screening at liver and kidney levels. TIL injection increased serum levels of hepatic and renal markers (ALP, ALT, AST, TC, TG, creatinine, and urea) with decreased total proteins. In parallel, TIL induced hepatic and renal oxidative stress as there was an increase in malondialdehyde levels, with a decrease in catalase and reduced glutathione activities. Of interest, pre-administration of RHO inhibited TIL-induced increase in hepato-renal markers, decreased oxidative stress, and increased liver and kidney antioxidant activities. Quantitative RT-PCR showed that TIL increased the liver's HSP70 (heat shock protein), NFkB, and TNF-alpha mRNA expression. Moreover, TIL upregulated the expression of desmin, nestin, and vimentin expression in the kidney. The upregulated genes were decreased significantly in the protective group that received RHO. Serum inflammatory cytokines and genes of inflammatory markers were affected in liver tissues (HSP70, NFkB, and TNF-alpha) and kidney tissues (desmin, nestin, and vimentin)-TIL-induced hepatic vacuolation and congestion together with glomerular atrophy. The immunoreactivity of PCNA and HMGB1 was examined immunohistochemically. At cellular levels, PCNA was decreased while HMGB1 immunoreactivity was increased in TIL-injected rats, which was improved by pre-administration of RHO. RHO administration protected the altered changes in liver and renal histology. Current findings support the possible use of RHO to shield the liver and kidney from the negative effects of tilmicosin.
C1 [Elgendy, Salwa A.; Elnoury, Heba A.] Benha Univ, Fac Med, Dept Pharmacol, Banha 13511, Egypt.
   [Soliman, Mohamed Mohamed] Taif Univ, Turabah Univ Coll, Dept Clin Lab Sci, POB 11099, Taif 21944, Saudi Arabia.
   [Shukry, Mustafa] Kafrelsheikh Univ, Fac Vet Med, Dept Physiol, Kafrelsheikh 33516, Egypt.
   [Mohammed, Lina Abdelhady; Nasr, Hend Elsayed] Benha Univ, Fac Med, Dept Med Biochem & Mol Biol, Banha 13511, Egypt.
   [Althobaiti, Saad] Taif Univ, Turabah Univ Coll, Dept Biol, Taif 21995, Saudi Arabia.
   [Almalki, Daklallah A.] Al Baha Univ, Fac Sci & Arts Al Mikhwah, Biol Dept, Al Baha, Saudi Arabia.
   [Alotaibi, Khalid S.; Albattal, Shatha B.] AlMaarefa Univ, Coll Appl Sci, Gen Sci & English Language Dept, Riyadh, Saudi Arabia.
C3 Egyptian Knowledge Bank (EKB); Benha University; Taif University;
   Egyptian Knowledge Bank (EKB); Kafrelsheikh University; Egyptian
   Knowledge Bank (EKB); Benha University; Taif University; Al Baha
   University; Almaarefa University
RP Soliman, MM (corresponding author), Taif Univ, Turabah Univ Coll, Dept Clin Lab Sci, POB 11099, Taif 21944, Saudi Arabia.
EM salwa.elabidine@fmed.bu.edu.eg; mmsoliman@tu.edu.sa;
   mostafa.ataa@vet.kfs.edu.eg; lina.mohamed@fmed.bu.edu.eg;
   hend.mosalm@fmed.bu.edu.eg; saed@tu.edu.sa; daalmalki@bu.edu.sa;
   Kaotaibi@um.edu.sa; sbattal@um.edu.sa; heba.elnoury@fmed.bu.edu.eg
RI albattal, shatha/PIH-8458-2026; Soliman, Mohamed Mohamed/ABJ-0997-2022;
   shukry, mustafa/AAB-9324-2019; Alotaibi, Khalid S/ODK-1260-2025;
   Mohammed, A.B./M-5736-2017; Althobaiti, Saed/GRS-4168-2022
OI albattal, shatha/0009-0009-4919-6300; Soliman, Mohamed
   Mohamed/0000-0001-7208-7123; Alotaibi, Khalid S/0009-0000-1333-4446; 
FU Taif University, Saudi Arabia [TU-DSPP-2024-24]; Clinical Pathology
   Departments, Faculty of Medicine at Benha University
FX The authors extend their appreciation to Taif University, Saudi Arabia,
   for supporting this work through project number (TU-DSPP-2024-24). The
   authors would like to thank the Pathology, Pharmacology, and Clinical
   Pathology Departments, Faculty of Medicine at Benha University, Egypt,
   for their invaluable technical and administrative support throughout
   this work.
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NR 74
TC 7
Z9 8
U1 1
U2 10
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0028-1298
EI 1432-1912
J9 N-S ARCH PHARMACOL
JI Naunyn-Schmiedebergs Arch. Pharmacol.
PD OCT
PY 2024
VL 397
IS 10
BP 7623
EP 7637
DI 10.1007/s00210-024-03089-5
EA APR 2024
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA I2O0O
UT WOS:001211478200001
PM 38689072
DA 2026-05-27
ER

PT J
AU Muklada, H
   Klein, JD
   Glasser, TA
   Dvash, L
   Azaizeh, H
   Halabi, N
   Davidovich-Rikanati, R
   Lewinsohn, E
   Landau, SY
AF Muklada, H.
   Klein, J. D.
   Glasser, T. A.
   Dvash, L.
   Azaizeh, H.
   Halabi, N.
   Davidovich-Rikanati, R.
   Lewinsohn, E.
   Landau, S. Y.
TI Initial evaluation of willow (Salix acmophylla) irrigated with
   treated wastewater as a fodder crop for dairy goats
SO SMALL RUMINANT RESEARCH
LA English
DT Article; Proceedings Paper
CT 12th International Goat Conference (ICG)
CY SEP 25-30, 2016
CL Antalya, TURKEY
SP Turkish Minist Agr & Livestock, Cukurova Univ, Sheep & Goat Breeder Assoc Turkey
DE Browse; Nutraceutical; Forage; Health; Caprine
ID NUTRITIVE-VALUE; NEW-ZEALAND; MILK; MANAGEMENT; LACTATION; CADMIUM;
   MAMBER; POPLAR; YIELD; NIRS
AB This research aimed at providing a first evaluation of willow tree (Salix acmophylla) irrigated by secondarily treated wastewater as a fodder for goats. The nutrient and mineral contents in stems and leaves of two willow types (termed "red" and "white" for their bark color) and the concentration of secondary compounds were established. The adaptation of naive goats to willow forage and its effect on the milk composition of late lactating goats were also studied. Willow fodder was composed of 45% leaves and 55% stems, on a DM basis; the weighted content of CP, ME, NDF, Ca, and P were (on a DM basis): 13.6%, 1.8 Mcal, 44.9%, 1.1%, and 0.2%, respectively. Lead, nickel and cadmium were found below the detection threshold in willow fodder and the concentrations of metals did not exceed the recommended ranges in feed. Intake was higher for red than for white willow fodder. The adaptation rate to white willow was low (27 g/d) but steady and intake was similar to that of clover hay after one week. White willow contained 1.2-fold more salicin (P < 0.05), 1.5-fold more gallic acid (P < 0.01) and 1.8-fold more kaempferol than red willow. The two types of willow did not differ in their concentrations of salicylic acid, hyperin, salidroside and helicon. No evidence was found that willow at the amounts consumed in this study - up to 500 g/d during the adaptation period and ca. 600 g/d in late lactation could be harmful to goats, as neither of the liver enzymes increased in blood, following exposure to willow. When Baladi (Mamber) goats at their third lactation at 240 days postpartum were provided with willow after grazing hours for a period of 10 days, milk yield was not affected. Somatic cell counts soared from 1.3*10(6) to up to 2.9*10(6) in the control group, but did not change in the group that was fed willow. These initial results imply that willow that is irrigated with treated wastewater can serve as medium-quality forage for dairy goats. Specific compounds contained in willow fodder may be of significant value in maintaining and improving the health and welfare of dairy goats.
C1 [Muklada, H.; Klein, J. D.; Dvash, L.; Halabi, N.; Landau, S. Y.] Agr Res Org, Inst Plant Sci, Dept Nat Resources, Volcani Ctr, POB 6, IL-50250 Bet Dagan, Israel.
   [Glasser, T. A.] Ramat Hanadiv Nat Pk, Zikhron Yaakov, Israel.
   [Azaizeh, H.] Univ Haifa, Inst Appl Res, Galilee Soc, IL-20200 Shefa Amr, Israel.
   [Azaizeh, H.] Tel Hai Coll, Dept Environm Sci, IL-12208 Upper Galilee, Israel.
   [Davidovich-Rikanati, R.; Lewinsohn, E.] Agr Res Org, Newe Yaar Res Ctr, Inst Plant Sci, IL-30095 Ramat Yishay, Israel.
C3 Volcani Institute of Agricultural Research; University of Haifa; Tel Hai
   Academic College
RP Muklada, H (corresponding author), Agr Res Org, Inst Plant Sci, Dept Nat Resources, Volcani Ctr, POB 6, IL-50250 Bet Dagan, Israel.
EM hussein@agri.gov.il
RI ; Muklada, Hussein/PDW-0456-2025
OI Ghasemi, Ebrahim/0000-0002-5248-1980; Muklada,
   Hussein/0000-0002-0176-549X
FU MERC (Middle East Regional Cooperation - U.S. Agency for International
   Development) [33-018]
FX This work was supported by MERC (Middle East Regional Cooperation - U.S.
   Agency for International Development - project 33-018). We are indebted
   to Ramat Hanadiv Nature Park and in particular to Mr Hugo Yan Trago for
   allowing us to plant the willow plots and use goats from the Ramat
   Hanadiv flock as experimental animals, to Mr. Albert Kaminer for
   logistic support, and to Mrs Liat Hadar for including this study in the
   frame of the scientific activity of the Park.
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TC 21
Z9 24
U1 0
U2 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0921-4488
EI 1879-0941
J9 SMALL RUMINANT RES
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VL 163
SI SI
BP 76
EP 83
DI 10.1016/j.smallrumres.2017.10.013
PG 8
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WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Agriculture
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PT J
AU Booker, A
   Jalil, B
   Frommenwiler, D
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AF Booker, Anthony
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TI The authenticity and quality of Rhodiola rosea products
SO PHYTOMEDICINE
LA English
DT Article
DE Rhodiola; Quality; Adulteration; Metabolomics; Herbal medicinal products
ID LIQUID-CHROMATOGRAPHY; VALUE CHAINS; PERFORMANCE; SPECTROSCOPY; ROOTS
AB Background\ Rhodiola rosea L. Crassulaceae, root (Golden Root, Arctic Root) is a high-value herbal medicinal product, registered in the UK for the treatment of stress-induced fatigue, exhaustion and anxiety based on traditional use and used throughout Europe as a herbal medicinal product for similar indications. Numerous unregistered supplements are also available. There are several Chinese species used in traditional Chinese medicine (TCM), including Rhodiola crenulata (Hook. f. & Thomoson) that is believed to be a common adulterant in the R. rosea value chain.
   Aims: The project is embedded in a larger study aiming to investigate the diverse value chains that lead to the production of R. rosea as an herbal medicinal product or supplement. Here we focus on a comparison of the quality of the finished products and assess any phytochemical variation between products registered under the Traditional Herbal Medicine Products Directive (THMPD) and products obtained from the market without any registration (i.e. generally unlicensed supplements). Our key aim is to establish the extent of the problem in terms of adulteration of consumer products claiming to contain R. rosea (or R. crenulata).
   Methods: Approximately 40 commercial products (granulated powders and extracts) were sourced from different suppliers. We analysed these samples using high performance thin layer chromatography (HPTLC), mass spectrometry (MS) and H-1 NMR spectroscopy coupled with multi-variate analysis software following a method previously developed by our group for the analysis of turmeric products.
   Results: We investigate the phytochemistry of the different species and assess the potential of R. crenulata as an adulterant at the end of the R. rosea value chains. The consistency of the products varies significantly. Approximately one fifth of commercial products that claimed to be R. rosea did not contain rosavin (the key reference markers used to distinguish R. rosea from related species). Moreover some products appeared not to contain salidroside, another marker compound found in other Rhodiola species. Approximately 80% of the remaining commercial products were lower in rosavin content than the registered products and appeared to be adulterated with other Rhodiola species.
   Conclusions: The variation in phytochemical constituents present in Rhodiola products available to European buyers via the internet and other sources is a major cause for concern. Adulteration with different species, and other sometimes unknown adulterants, appears to be commonplace. Good quality systems and manufacturing practices, including those required under the THMPD, enable consumers to have confidence that products are authentic and meet a high specification for quality and safety. (C) 2015 Elsevier GmbH. All rights reserved.
C1 [Booker, Anthony; Jalil, Banaz; Zhai, Lixiang; Heinrich, Michael] UCL Sch Pharm, Ctr Pharmacognosy & Phytotherapy, Res Cluster Biodivers & Med, Brunswick Sq, London, England.
   [Frommenwiler, Debora; Reich, Eike] CAMAG AG, CH-4132 Muttenz, Switzerland.
   [Zhai, Lixiang] Guangdong Pharmaceut Univ, Guangzhou, Guangdong, Peoples R China.
   [Kulic, Zarko] Dr Willmar Schwabe GmbH & Co KG, Preclin Res, Karlsruhe, Germany.
C3 University of London; University College London; University of London
   School of Pharmacy; Guangdong Pharmaceutical University; Dr. Willmar
   Schwabe GmbH & Co. KG
RP Heinrich, M (corresponding author), UCL Sch Pharm, Ctr Pharmacognosy & Phytotherapy, Res Cluster Biodivers & Med, Brunswick Sq, London, England.
EM m.heinrich@ucl.ac.uk
RI Heinrich, Michael/C-3727-2013; ZHAI, Lixiang/M-2660-2019; Booker,
   Anthony/K-8034-2015
OI Jalil, Banaz/0000-0002-1535-3744; ZHAI, Lixiang/0000-0002-3907-5910;
   Booker, Anthony/0000-0002-0471-0638; Kulic, Zarko/0009-0000-0598-6700
FU Schwabe GmbH & Co. KG, Germany
FX Anthony Booker's research position is funded through a charitable
   donation by Dr. Willmar Schwabe GmbH & Co. KG, Germany. The donor had no
   influence on the design of the experiments and their interpretation.
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NR 15
TC 81
Z9 86
U1 2
U2 98
PU ELSEVIER GMBH, URBAN & FISCHER VERLAG
PI JENA
PA OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY
SN 0944-7113
J9 PHYTOMEDICINE
JI Phytomedicine
PD JUN 15
PY 2016
VL 23
IS 7
BP 754
EP 762
DI 10.1016/j.phymed.2015.10.006
PG 9
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA DM7IM
UT WOS:000376533500009
PM 26626192
DA 2026-05-27
ER

PT J
AU Gao, K
   Zhang, W
   Zhao, MN
   Xu, D
   Tao, XR
   Li, WT
   Liu, MY
   Guo, C
   Lu, YY
   Wang, JW
AF Gao, Kai
   Zhang, Wei
   Zhao, Meina
   Xu, Dong
   Tao, Xingru
   Li, Wangting
   Liu, Meiyou
   Guo, Chao
   Lu, Yunyang
   Wang, Jingwen
TI Bioactive compounds and multitarget action mechanism of Erzhi pills in
   alleviating metabolic dysfunction-associated steatohepatitis
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE MASH; Traditional Chinese medicine; Bioactive compounds; Multi-pathway
ID NONALCOHOLIC FATTY LIVER; NASH; RECEPTORS; HIPPO; NAFLD
AB Ethnopharmacological relevance: Erzhi pills (EZP), as a traditional Chinese herbal prescription, have protective effects against various forms of liver injury. However, the therapeutic potential, bioactive ingredients and mechanism of action of EZP for metabolic dysfunction-associated steatohepatitis (MASH) have not been completely elucidated. Aim of the study: This research aimed to evaluate the therapeutic effect of EZP and its bioactive compounds on MASH. Methods: Two typical animal models of MASH, mice fed a methionine-choline-deficient (MCD) diet (representing non-obese MASH) and mice fed a high-fat and high-cholesterol diet (HFHC) (representing obese MASH), were used to investigate the effect of EZP on MASH in vivo. Transcriptomic and proteomic analysis were performed to elucidate the under lying mechanisms of EZP. The compositional analysis of EZP in MASH mice was conducted using UPLC-Q-Exactive-Orbitrap-MS. Free fatty acid (FFA)-stimulated HepG2 cells and transforming growth factor (31 (TGF-(31)-activated LX-2 cells were applied to further explore the effects and mechanisms of bioactive compounds from EZP. Results: Our results indicate that the EZP mitigates hepatic lipid buildup, insulin resistance, inflammation, apoptosis, and fibrosis in different diet-induced MASH mice. Through multiomic analyses, UPLC-Q-ExactiveOrbitrap-MS analysis and molecular docking, we have identified that EZP exerts therapeutic effects on MASH involves activation of PPAR alpha and PI3K/AKT/FoxO1 pathways, and inhibition of NLRP3, p53, and yes-associated protein (YAP) signaling pathways. It had been established that wedelolactone (wed), specnuezhenide (Spe), salidroside (Sal), and echinocystic acid3-o-glucoside (Ech) served as the primary bioactive compounds in EZP for its therapeutic effect against MASH. In vitro experiments have confirmed that Spe, Sal, and Ech mitigate lipid accumulation by activating PPAR alpha. Additionally, Spe and Sal improve insulin resistance through the activation of the PI3K/AKT/FoxO1 signaling pathway. Furthermore, Wed, Sal, and Ech inhibit the NLRP3 inflammasome and p53 signaling pathways, thereby reducing inflammatory markers and providing anti-apoptotic effects. Moreover, Wed and Ech inhibit the activation of hepatic stellate cells (HSCs) by blocking the YAP signaling pathway. Notably, Sal and Ech were the primary bioactive components of EZP, and their combined anti-MASH efficacy was comparable to that of EZP. Conclusion: This study is the comprehensive elucidation of the active ingredients and mechanism of action behind EZP in its anti-MASH properties. EZP, as well as the combination of Sal and Ech are potential treatment for MASH that targets multiple signaling pathways.
C1 [Gao, Kai; Zhang, Wei; Zhao, Meina; Xu, Dong; Tao, Xingru; Li, Wangting; Liu, Meiyou; Guo, Chao; Wang, Jingwen] Fourth Mil Med Univ, Xijing Hosp, Dept Pharm, Xian 710032, Peoples R China.
   [Lu, Yunyang] Fourth Mil Med Univ, Sch Pharm, Dept Chinese Mat Med & Nat Med, Xian 710032, Peoples R China.
   [Lu, Yunyang] Fourth Mil Med Univ, Xijing Hosp, Res Inst, Xian, Peoples R China.
C3 Air Force Medical University; Air Force Medical University; Air Force
   Medical University
RP Wang, JW (corresponding author), Fourth Mil Med Univ, Xijing Hosp, Dept Pharm, Xian 710032, Peoples R China.
EM wangjingwen8021@163.com
RI ; Tao, xingru/OFM-4374-2025; Xu, Dong/PQW-8445-2026; Zhao,
   Meina/KBP-8496-2024
OI Gao, Kai/0000-0003-2317-2019; 
FU Clinical Medicine and Pharmacy Research Center, Fourth Military Medical
   University [LHJJ2024-YX03, LHJJ2024-YX21]; Health Research and
   Innovation Capacity Enhancement Program of Shaanxi Province [2023
   PT-10]; Project for enhancing medical staff training of Xijing Hospital
   [XJZT24CZ14, XJZT24QN55]
FX This study was supported by the financial support of the Clinical
   Medicine and Pharmacy Research Center, Fourth Military Medical
   University (LHJJ2024-YX03, LHJJ2024-YX21) , the project for enhancing
   medical staff training of Xijing Hospital (XJZT24CZ14, XJZT24QN55) and
   the Health Research and Innovation Capacity Enhancement Program of
   Shaanxi Province (2023 PT-10) .
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NR 56
TC 2
Z9 2
U1 3
U2 4
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
EI 1872-7573
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD JAN 30
PY 2026
VL 355
AR 120737
DI 10.1016/j.jep.2025.120737
EA OCT 2025
PN B
PG 16
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA 9DO1A
UT WOS:001603787000006
PM 41093119
DA 2026-05-27
ER

PT J
AU He, J
   Zhou, D
   Yan, B
AF He, Jia
   Zhou, Dong
   Yan, Bo
TI Eriocitrin alleviates oxidative stress and inflammatory response in
   cerebral ischemia reperfusion rats by regulating phosphorylation levels
   of Nrf2/NQO-1/HO-1/NF-κB p65 proteins
SO ANNALS OF TRANSLATIONAL MEDICINE
LA English
DT Article
DE Eriocitrin; cerebral ischemia reperfusion (CI/R); oxidative injury;
   inflammatory response; nuclear factor erythroid 2-related factor pathway
   (Nrf2 pathway)
ID ACUTE LUNG INJURY; APOPTOSIS; CELLS; OVEREXPRESSION; SALIDROSIDE;
   SUPPRESSES; CYTOKINES; PROTECTS; PATHWAY; STROKE
AB Background: Cerebral ischemia (CI) can lead to ischemic stroke. The most effective therapy for cerebral ischemic stroke is the early restoration of blood reperfusion. However, reperfusion after CI can result in cerebral ischemia reperfusion (CI/R) injury. This study aimed to detect the effect of eriocitrin on cerebral I/R injury and investigate the underlying mechanism.
   Methods: Seventy male Sprague-Dawley (SD) rats were randomly divided into 5 groups: the control group, the cerebral I/R group, the I/R + eriocitrin 8 mg/kg group, the I/R + eriocitrin 16 mg/kg group, and the I/R + eriocitrin 32 mg/kg group. Different doses of eriocitrin or 0.5% carboxymethyl cellulose sodium were administrated to the rats once daily for 7 days before middle cerebral artery occlusion (MCAO). PCR staining was performed to observe cerebral infarction. Hematoxylin and eosin (H&E) staining was carried out to observe the damage to the brain tissue. Terminal-deoxynucleotidyl transferase mediated nick end labeling (TUNEL) was used to detect apoptosis. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the relative mRNA levels of related molecules. Western blot was used to detect the expression of related proteins. The detection kits were used to detect superoxide dismutase (SOD) and lactic dehydrogenase (LDH) activity, and malondialdehyde (MDA) content respectively. Enzyme-linked immunosorbent assay (ELISA) was used to detect TNF-radiation, interleukin-6 (IL-6), and interleukin-10 (IL-10).
   Results: The results showed that Eriocitrin significantly reduced the cerebral infarct volume, cerebral water content, and cerebral indexes. Eriocitrin treatment alleviated pathological injury, promoted cell proliferation, and inhibited cell apoptosis. Eriocitrin upregulated SOD activity and downregulated MDA and LDH content. Eriocitrin also effectively decreased the levels of IL-6 and tumor necrosis factor-alpha (TNF-alpha), but increased the content of IL-10 in serum and brain tissues. Furthermore, Eriocitrin increased the phosphorylation of nuclear factor erythroid 2-related factor (Nrf2), as well as the expressions of heme-oxygenase-1 (HO-1) and quinine oxidoreductase 1 (NQO1). Moreover, Eriocitrin decreased the phosphorylation of nuclear factor-kappa B (NF-kappa B) p65.
   Conclusions: Our results indicated that Eriocitrin attenuated oxidative injury and inflammatory response in rats with CI/R via the Nrf2/HO-1/NQO1/NF-kappa B signaling pathway.
C1 [He, Jia; Zhou, Dong; Yan, Bo] Sichuan Univ, West China Hosp, Dept Neurol, 37 Guoxue Lane, Chengdu 610041, Peoples R China.
   [He, Jia] 363 Hosp, Dept Neurol, Chengdu 610041, Peoples R China.
C3 Sichuan University
RP Zhou, D (corresponding author), Sichuan Univ, West China Hosp, Dept Neurol, 37 Guoxue Lane, Chengdu 610041, Peoples R China.
EM ktk7609@163.com
RI He, Jialu/MVY-0732-2025
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NR 37
TC 56
Z9 73
U1 1
U2 14
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2305-5839
EI 2305-5847
J9 ANN TRANSL MED
JI ANN. TRANSL. MED.
PD JUN
PY 2020
VL 8
IS 12
AR 757
DI 10.21037/atm-20-4258
PG 11
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA MI6ZH
UT WOS:000547552700043
PM 32647682
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Wang, QC
   Bao, HY
AF Wang, Qingchun
   Bao, Haiying
TI Integrated metagenomics and metabolomics reveal the dynamic mechanism in
   the rhizosphere soil of Morus alba L. and Fraxinus
   mandshurica Rupr. with Inonotus hispidus
SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY
LA English
DT Article
DE metagenomics; metabolomics; rhizosphere soil; <italic>Morus
   alba</italic> L.; <italic>Inonotus hispidus</italic>; <italic>Fraxinus
   mandshurica </italic>Rupr.
AB Inonotus hispidus is a medicinal fungus that grows on Morus alba L., Fraxinus mandshurica Rupr., and Ziziphus jujuba Mill. However, there have been no reports on the comparative study of microbial diversity and metabolites in the rhizosphere soil of different tree species, specifically M. alba and F. mandshurica, growing with I. hispidus. Therefore, this study conducts a multi-omics joint analysis utilizing metagenomics and metabolomics to explore the differences in the synergistic mechanisms between different hosts of I. hispidus. Using metagenomics technology, a total of 177 phyla and 2,651 genera were identified as significantly different. At both the phylum and genus levels, Actinomycetota and Pseudomonadota as well as Solirubrobacter and Bradyrhizobium emerged as the predominant phyla and genera, respectively. In the Kyoto Encyclopedia of Genes and Genomes database, carbohydrate and amino acid metabolisms were identified as the primary metabolic pathways. Differential analysis of these metabolic pathways revealed that glucokinase and pyruvate kinase were downregulated. Additionally, metabolomics analysis identified 558 differential metabolites, with tyrosine metabolism being the foremost metabolic pathway involved. This pathway included five differential metabolites, among which salidroside, 3,4-dihydroxyphenylpropanoate, rosmarinate, and homovanillate were significantly upregulated in M. alba in association with I. hispidus. Furthermore, correlation analysis indicated that Enhydrobacter was positively correlated with 10 differential metabolites, while Gaiella, Haladaptatus, Jiangella, and Prauserella showed negative correlations. This study lays a solid foundation for elucidating the interactions between I. hispidus and its hosts, as well as for the effective utilization of I. hispidus resources across different tree species.IMPORTANCEInonotus hispidus, which is traditionally recognized as the authentic source of the medicinal fungus, primarily grows on Morus alba L. It is commonly found in ancient regions along the Yellow River, including Linqing, Xiajin, and Wudi in Shandong, as well as Chengde in Hebei Province and Aksu in Xinjiang. In traditional Chinese medicine, it is known as "Sanghuang" and has a long history of medicinal use. In addition to M. alba, I. hispidus also grows on other broad-leaved species, such as Ulmus macrocarpa, Acer truncatum, and Fraxinus mandshurica. The lack of fundamental research on its multi-host and -source diversity has hindered its industrial development and medicinal value. Consequently, this study employs metagenomics and metabolomics to investigate the rhizosphere soil microbial diversity and differential metabolites associated with the different host plants of I. hispidus, specifically M. alba and F. mandshurica, with the aim of providing a reference for its resource conservation and development.
C1 [Wang, Qingchun; Bao, Haiying] Jilin Agr Univ, Key Lab Dev & Utilizat Fungi Tradit Chinese Med Re, Changchun, Peoples R China.
   [Wang, Qingchun; Bao, Haiying] Jilin Agr Univ, Key Lab Edible Fungal Resources & Utilizat North, Changchun, Peoples R China.
C3 Jilin Agricultural University; Jilin Agricultural University
RP Bao, HY (corresponding author), Jilin Agr Univ, Key Lab Dev & Utilizat Fungi Tradit Chinese Med Re, Changchun, Peoples R China.; Bao, HY (corresponding author), Jilin Agr Univ, Key Lab Edible Fungal Resources & Utilizat North, Changchun, Peoples R China.
EM baohaiying@jlau.edu.cn
OI Bao, Haiying/0000-0003-0277-8521
FU National Natural Science Foundation of China [32070021]; Research and
   Development of Authentic Medicinal Materials and High-quality New
   Varieties of Sanghuang in the Old Course of the Yellow River [20240180]
FX This research was supported by the National Natural Science Foundation
   of China (no. 32070021) and the Research and Development of Authentic
   Medicinal Materials and High-quality New Varieties of Sanghuang in the
   Old Course of the Yellow River (no. 20240180).
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NR 37
TC 1
Z9 1
U1 11
U2 12
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0099-2240
EI 1098-5336
J9 APPL ENVIRON MICROB
JI Appl. Environ. Microbiol.
PD DEC 23
PY 2025
VL 91
IS 12
DI 10.1128/aem.01251-25
EA NOV 2025
PG 16
WC Biotechnology & Applied Microbiology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Microbiology
GA AD4IC
UT WOS:001610220600001
PM 41211921
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Liu, MW
   Su, MX
   Zhang, W
   Zhang, LM
   Wang, YH
   Qian, CY
AF Liu, Ming-Wei
   Su, Mei-Xian
   Zhang, Wei
   Zhang, Lin-Ming
   Wang, Yun-Hui
   Qian, Chuan-Yun
TI Rhodiola rosea suppresses thymus T-lymphocyte apoptosis by
   downregulating tumor necrosis factor-α-induced protein 8-like-2 in
   septic rats
SO INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
LA English
DT Article
DE Rhodiola rosea; tumor necrosis factor-alpha-induced protein 8-like-2; T
   lymphocyte; apoptosis; caecal ligation and puncture; mice
ID IMMUNE-RESPONSE; INFLAMMATORY RESPONSE; NEGATIVE REGULATOR; TNFAIP8
   FAMILY; CELL-DEATH; SEPSIS; TIPE2; SALIDROSIDE; INNATE; EXPRESSION
AB In recent years, several studies have shown that Rhodiola rosea can enhance cellular immunity and humoral immune function in mice, and thus, it has become a research hotspot. However, its underlying mechanism of action has remained elusive. The present study investigated whether Rhodiola rosea was able to downregulate the expression of tumor necrosis factor-a-inducible protein 8-like 2 (TIPE2), thereby inhibiting the expression of apoptotic genes, attenuating T-lymphocyte apoptosis and improving immunity in septic mice. A mouse model of caecal ligation and puncture (CLP)-induced sepsis was established, and animals in the treatment group were pre-treated with an intraperitoneal injection of Rhodiola rosea extract, while animals in the control group and sham-operated group were injected with an equivalent amount of normal saline. TIPE2, B-cell lymphoma 2 (Bcl-2), Fas and Fas ligand (FasL) mRNA and protein levels in thymic T cells were determined using reverse transcription quantitative polymerase chain reaction and western blot analysis, respectively. Furthermore, the thymus T-lymphocyte apoptosis rate, thymus T-lymphocyte count and thymus T-lymphocyte sub-sets were assessed using flow cytometry. Levels of T-helper cell type 1 (Th1) cytokines [Interleukin (IL)-2, IL-12 and interferon (IFN)-gamma] and Th2 cytokines (IL-4 and IL-10) were determined using ELISA. The results showed that, compared to that in the CLP group, the expression of TIPE2, Fas and FasL in the treatment group was significantly decreased, while the expression of Bcl-2 was increased (P<0.05). The thymus lymphocyte count in the CLP group was significantly higher compared with that in the treatment group (P<0.05). Furthermore, the apoptotic rate of thymus T-lymphocytes in the treatment group was significantly lower than that in the CLP group (P<0.05). In addition, treatment with Rhodiola rosea rescued decreased in the counts of the CD3+ T and CD4+ T sub-sets of thymus T lymphocytes in the CLP group (P<0.05), while not affecting the increased levels of Th2 cytokines (IL-4 and IL-10) in the CLP group compared with those in the control groups. In addition, the Th1 cytokines (IL-12, IL-2 and IFN-gamma) were significantly increased (P<0.05) in the CLP group, and treatment with Rhodiola rosea led to further increases. The thymus index of septic mice treated with Rhodiola rosea as well as their survival rate were improved as compared with those in the CLP group. These findings suggested that Rhodiola rosea has protective effects against sepsis by decreasing apoptosis, increasing Th1 cytokines and enhancing the host's immunity via the regulation of TIPE2 expression.
C1 [Liu, Ming-Wei; Zhang, Wei; Wang, Yun-Hui; Qian, Chuan-Yun] Kunming Med Univ, Affiliated Hosp 1, Dept Emergency, Kunming 650032, Yunnan, Peoples R China.
   [Su, Mei-Xian] Kunming Med Univ, Affiliated Hosp 2, Dept Emergency, Kunming 650101, Yunnan, Peoples R China.
   [Zhang, Lin-Ming] Kunming Med Univ, Affiliated Hosp 1, Dept Neurol, Kunming 650032, Yunnan, Peoples R China.
C3 Kunming Medical University; Kunming Medical University; Kunming Medical
   University
RP Qian, CY (corresponding author), Kunming Med Univ, Affiliated Hosp 1, Dept Emergency, 295 Xichang Rd, Kunming 650032, Yunnan, Peoples R China.
EM 758437603@126.com
RI Liu, Ming-Wei/AFL-8981-2022
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NR 54
TC 29
Z9 40
U1 1
U2 24
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1107-3756
EI 1791-244X
J9 INT J MOL MED
JI Int. J. Mol. Med.
PD AUG
PY 2015
VL 36
IS 2
BP 386
EP 398
DI 10.3892/ijmm.2015.2241
PG 13
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA CN8GE
UT WOS:000358677000008
PM 26063084
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Du, XQ
   Wang, XR
   Zhang, RD
   Chen, Y
   Chen, Q
   Yao, J
   Shi, LP
   Ren, Y
AF Du, Xuqin
   Wang, Xiaorong
   Zhang, Ruodai
   Chen, Yong
   Chen, Qian
   Yao, Jing
   Shi, Lipeng
   Ren, Yi
TI Standardized Rhodiola rosea injection for left ventricular
   remodeling and inflammation in patients with HFrEF: a systematic review
   and meta-analysis
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE standardized Rhodiola rosea injection; heart failure with reduced
   ejection fraction (HFrEF); left ventricular remodeling (LVR);
   inflammation; systematic review; meta-analysis
ID HEART-FAILURE; SALIDROSIDE; INTERVENTIONS; CELLS
AB Background Heart failure with reduced ejection fraction (HFrEF) affects a substantial portion of the global population, with left ventricular remodeling (LVR) and inflammation identified as key contributors to disease progression. Standardized Rhodiola rosea Injection (SRRI) is a pharmacopoeia-based botanical drug preparation derived from Rhodiola rosea, widely used in China for heart failure treatment. It is standardized in composition and quality control, with known antioxidant, anti-inflammatory, and anti-fibrotic properties. However, comprehensive evaluations of SRRI's effects on LVR and inflammatory mediators in HFrEF patients are limited. Purpose To evaluate the effects of SRRI on LVR and inflammatory mediators in patients with HFrEF. Methods A systematic review and meta-analysis were conducted following PRISMA and Cochrane guidelines. Eight databases were searched for randomized controlled trials (RCTs) on SRRI in HFrEF treatment with studies identified from inception to 31 October 2024. Quality assessment of the included studies was conducted using the Cochrane Collaboration's risk of bias tool and the modified Jadad scale. Statistical analysis was performed using Stata version 17.0, with sensitivity analyses conducted by sequentially excluding studies to assess the robustness of findings. Publication bias was evaluated using Egger's test. Results Twenty-five RCTs with 2,325 participants were included. SRRI significantly improved LVR, indicated by increased LVEF (MD = 6.81, 95% CI: 5.71 to 7.91, P < 0.00001), reduced LVEDD (MD = -4.37, 95% CI: -5.42 to -3.33, P < 0.00001), and decreased LVESD (MD = -4.48, 95% CI: -5.42 to -3.58, P < 0.00001). Additionally, SRRI effectively reduced inflammatory mediators, including TNF-alpha (MD = -10.37, 95% CI: -12.96 to -7.78, P < 0.00001), IL-6 (MD = -6.99, 95% CI: -8.88 to -5.11, P < 0.00001), and hs-CRP (MD = -2.58, 95% CI: -3.37 to -1.79, P < 0.00001). SRRI also significantly reduced BNP (MD = -105.10, 95% CI: -132.29 to -77.90, P < 0.00001) and NT-pro BNP (MD = -415.95, 95% CI: -553.00 to -278.89, P < 0.00001). Clinical effectiveness was improved, with no significant increase in adverse reactions (RR = 0.86, 95% CI: 0.59 to 1.25, P = 0.44). Sensitivity analyses confirmed the robustness of these findings, and no significant publication bias was detected. Conclusion SRRI appears to effectively enhance LVR, reduce inflammatory mediators, and improve clinical effectiveness in HFrEF patients while maintaining a favorable safety profile. However, the current evidence is limited by methodological shortcomings, and further well-designed, multicenter RCTs are needed to validate these findings, especially in diverse populations and over long-term treatment durations. Systematic Review Registration https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=603884, Identifier CRD42024603884.
C1 [Du, Xuqin] Chongqing Univ Chinese Med, Sch Tradit Chinese Med, Chongqing, Peoples R China.
   [Wang, Xiaorong; Zhang, Ruodai; Chen, Qian; Yao, Jing] Chongqing Med Univ, Coll Tradit Chinese Med, Chongqing, Peoples R China.
   [Chen, Yong; Shi, Lipeng; Ren, Yi] Chongqing Tradit Chinese Med Hosp, Dept Class Tradit Chinese Med, Chongqing, Peoples R China.
C3 Chongqing Medical University
RP Shi, LP; Ren, Y (corresponding author), Chongqing Tradit Chinese Med Hosp, Dept Class Tradit Chinese Med, Chongqing, Peoples R China.
EM lipeng_shi@outlook.com; cqszyyzyjdk@163.com
FU National Natural Science Foundation of China [8247296]; National Natural
   Science Foundation of China Youth Science Foundation Project [82405234];
   Chongqing University of Chinese Medicine "Three-Tier Distinguished
   Teacher" Scientific Research Enhancement Program [SQMS2024QNXM-008];
   Chongqing Leading Medical Talent Project [YXLJ202401]; Chongqing Youth
   Talent Support Program [CQYC202005018]
FX The author(s) declare that financial support was received for the
   research, authorship, and/or publication of this article. This work was
   supported by the National Natural Science Foundation of China (No.
   8247296), the National Natural Science Foundation of China Youth Science
   Foundation Project (No. 82405234), the Chongqing University of Chinese
   Medicine "Three-Tier Distinguished Teacher" Scientific Research
   Enhancement Program (No. SQMS2024QNXM-008), the Chongqing Leading
   Medical Talent Project (No. YXLJ202401), and the Chongqing Youth Talent
   Support Program (No. CQYC202005018).
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NR 62
TC 1
Z9 1
U1 2
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD MAR 3
PY 2025
VL 16
AR 1536686
DI 10.3389/fphar.2025.1536686
PG 17
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 0FO3X
UT WOS:001446179000001
PM 40098619
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Lin, TX
   Huang, L
   Cheng, NN
   Wang, YZ
   Ning, Z
   Huang, SK
   Wu, YH
   Chen, TB
   Su, SK
   Lin, Y
AF Lin, Tianxing
   Huang, Lei
   Cheng, Ningna
   Wang, Yuzhen
   Ning, Zhen
   Huang, Shaokang
   Wu, Yuanhua
   Chen, Tianbao
   Su, Songkun
   Lin, Yan
TI The in vitro and in vivo antibacterial activities of
   uniflorous honey from a medicinal plant, Scrophularia ningpoensis
   Hemsl., and characterization of its chemical profile with UPLC-MS/MS
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Honey; Antibacterial; Mechanism; In vitro; In vivo; Untargeted
   metabolomics
ID NECROSIS-FACTOR-ALPHA; STAPHYLOCOCCUS-AUREUS; HELICOBACTER-PYLORI;
   BIOFILM FORMATION; NATURAL-PRODUCTS; BACTERIA; BIOSYNTHESIS; PEPTIDES;
   DISEASES; GROWTH
AB Ethnopharmacological relevance: According to the Compendium of Materia Medica, honey has been used as a traditional medicine in treatment against mucositis, tinea, hemorrhoids and psoriasis. In complementary medicine, due to its significant antimicrobial activity, honey has been widely used as a remedy for skin wounds and gastrohelcosis for thousands of years.
   Aim of the study: This study is aimed at exploring the antimicrobial activity and mechanisms of honey sourced from medicinal plants, and revealing the composition-activity relationship, to facilitate their complementary and alternative application in the therapy of bacterial infectious diseases.
   Materials and methods: Eight kinds of medicinal plant-derived uniflorous honey, native to China, were gathered. Their antimicrobial activities were evaluated in vitro, and then in vivo with the systemically infected mouse model and the acute skin infection model. SYTOX uptake assay, scanning electron microscopy, DNA binding assay, and quantitative real-time PCR, were carried out to elucidate the antibacterial mechanisms. This was followed by an investigation of the componential profile with the UPLC-MS/MS technique.
   Results: It was found that Scrophularia ningpoensis Hemsl. (figwort) honey (S. ningpoensis honey) exhibited broad-spectrum and the strongest antibacterial potency (MICs of 7.81-125.00%, w/v), comparable to manuka honey. In the in vivo assays, S. ningpoensis honey significantly decreased the bacterial load of the muscles under the acute MRSA-infected skin wounds; the sera level of TNF-alpha in the S. aureus and P. aeruginosa-infected mice decreased by 45.38% and 51.75%, respectively, after the treatment of S. ningpoensis honey (125 mg/10 g). It was capable of killing bacteria through disrupting the cell membranes and the genomic DNA, as well as down-regulating the expression of genes associated with virulence, biofilm formation and invasion, including icaA, icaD, eno, sarA, agrA, sigB, fib and ebps in S. aureus, and last, lasR, rhII, rhlR and algC in P. aeruginosa. Apart from H2O2, some other nonperoxide compounds such as adenosine, chavicol, 4-methylcatechol, trehalose, palmitoleic acid and salidroside, might play a vital role in the antibacterial properties of S. ningpoensis honey.
   Conclusions: This is the first study to thoroughly investigate the antibacterial activity, mode of action, and componential profile of S. ningpoensis honey. It suggested that S. ningpoensis honey might be a potential supplement or substitute for manuka honey, for the prevention or treatment of bacterial infections. It will facilitate the precise application of medicinal plant-sourced honey, provide a new thread for the development of antibacterial drugs, and assist in the distinction of different kinds of honey.
C1 [Lin, Tianxing; Huang, Lei; Cheng, Ningna; Wang, Yuzhen; Ning, Zhen; Huang, Shaokang; Wu, Yuanhua; Su, Songkun; Lin, Yan] Fujian Agr & Forestry Univ, Coll Bee Sci, Coll Anim Sci, 15 Shangxiadian Rd, Fuzhou 350002, Peoples R China.
   [Lin, Tianxing] Fujian Agr & Forestry Univ, Coll Marine Sci, Fuzhou 350002, Peoples R China.
   [Chen, Tianbao] Queens Univ, Sch Pharm, Nat Drug Discovery Grp, Belfast BT9 7BL, Antrim, North Ireland.
C3 Fujian Agriculture & Forestry University; Fujian Agriculture & Forestry
   University; Queens University Belfast
RP Su, SK (corresponding author), Fujian Agr & Forestry Univ, Coll Bee Sci, Coll Anim Sci, 15 Shangxiadian Rd, Fuzhou 350002, Peoples R China.; Lin, Y (corresponding author), Fujian Agr & Forestry Univ, Coll Marine Sci, Coll Anim Sci, Coll Bee Sci, 15 Shang Xiadian Rd, Fuzhou 350002, Peoples R China.
EM susongkun@zju.edu.cn; ylin19@qub.ac.uk
RI ; Lin, Yan/AAH-1808-2020
OI Lin, Tianxing/0000-0001-8939-5579; Lin, Yan/0000-0002-0351-3763
FU Natural Science Foundation of Fujian Province [2019J01408]; Outstanding
   Young Scientist Program of Fujian Agriculture and Forestry University
   [xjq201916]; National Natural Science Foundation of China [31772684];
   Fuzhou Science and Technology Project [2019-N-3, KH190316A, KH190025A];
   earmarked fund for CARS [CARS-44-KXJ4]
FX This work was supported by the Natural Science Foundation of Fujian
   Province [No. 2019J01408]; the Outstanding Young Scientist Program of
   Fujian Agriculture and Forestry University [No. xjq201916]; the National
   Natural Science Foundation of China [No. 31772684]; the Fuzhou Science
   and Technology Project [2019-N-3, KH190316A, KH190025A]; and the
   earmarked fund for CARS [No. CARS-44-KXJ4].
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NR 94
TC 17
Z9 18
U1 7
U2 84
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
EI 1872-7573
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD OCT 5
PY 2022
VL 296
AR 115499
DI 10.1016/j.jep.2022.115499
EA JUN 2022
PG 17
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA 4O9BJ
UT WOS:000854987500004
PM 35752262
DA 2026-05-27
ER

PT J
AU Li, N
   Chen, K
   Bai, JR
   Geng, ZJ
   Tang, Y
   Hou, Y
   Fan, FF
   Ai, XP
   Hu, Y
   Meng, XL
   Wang, XB
   Zhang, Y
AF Li, Ning
   Chen, Ke
   Bai, Jinrong
   Geng, Zangjia
   Tang, Yan
   Hou, Ya
   Fan, Fangfang
   Ai, Xiaopeng
   Hu, Yao
   Meng, Xianli
   Wang, Xiaobo
   Zhang, Yi
TI Tibetan medicine Duoxuekang ameliorates hypobaric hypoxia-induced brain
   injury in mice by restoration of cerebrovascular function
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Tibetan medicine; Duoxuekang; Hypobaric hypoxia; Brain injury;
   Cerebrovascular function
ID INDUCED OXIDATIVE STRESS; VASCULAR-PERMEABILITY; ALZHEIMERS-DISEASE;
   BLOOD-FLOW; INFLAMMATION; QUERCETIN; CURCUMIN; OXYGEN; RATS; L.
AB Ethnopharmacological relevance: Duoxuekang (DXK,) is a clinical experience prescription of CuoRu-Cailang, a famous Tibetan medicine master, which has effective advantages in the treatment of hypobaric hypoxia (HH)-induced brain injury. However, its underlying mechanisms remain unclear.
   Aim of the study: The present study was designed to investigate the effects of DXK on cerebrovascular function of HH-induced brain injury in mice.
   Materials and methods: DSC-MR imaging was used to evaluate the effect of DXK on the brain blood perfusion of patients with hypoxic brain injury. HPLC analysis was used to detect the content of salidmside, gallic acid, tyrosol, corilagin, ellagic acid, isorhamnetin, quercetin and gingerol in DXK. The model of HH-induced brain injury in mice was established by an animal hypobaric and hypoxic chamber. The BABL/c mice were randomly divided into six groups: control group, model group, Hongjingtian oral liquid group (HOL, 3.3 ml/kg) and DXK groups (0.9, 1.8 and 3.6 g/kg). All mice (except the control group) were intragastrically administrated for a continuous 7 days and put into the animal hypobaric and hypoxic chamber after the last intragastric administration. Hematoxylin-eosin staining was employed to evaluate the pathological changes of brain tissue. Masson and Weigert stainings were used to detect the content of collagen fibers and elastic fibers of brain, respectively. Routine blood test and biochemical kits were used to analyze hematological parameters and oxidative stress indices. Immunofluorescence staining was applied to detect the protein levels of VEGF, CD31/vWF and alpha-SMA.
   Results: The results of DSC-MR imaging confirmed that DXK can increased CBV in the left temporal lobe while decreased MTT in the right frontal lobe, right temporal lobe and right occipital lobe of the brain. DXK contains salidroside, gallic acid, tymsol, corilagin, ellagic acid, isorhamnetin, quercetin and gingerol. Compared with the model group, DXK can ameliorate the atrophy and deformation, and increase the number of pyramidal neurons in hippocampal CA3 area and cortical neurocytes. Masson and Weigert stainings results revealed that DXK can significantly increase the content of collagen fibers and elastic fibers in brain. Routine blood test results demonstrated that DXK can dramatically decrease the levels of WBC, MCH and MCHC, while increase RBC, HGB, HCT, MCV and PLT in the blood samples. Biochemical results revealed that DXK can markedly increase SOD, CAT and GSH activities, while decrease MDA activity. Immunofluorescence revealed that DXK can notably increase the protein levels of VEGF, CD31/vWF and alpha-SMA.
   Conclusions: In conclusion, this study proved that DXK can ameliorate HH-induced brain injury by improving brain blood perfusion, increasing the number of collagen and elastic fibers and inhibiting oxidative stress injury. The underlying mechanisms may be involved in maintaining the integrity of cerebrovascular endothelial cells and vascular function. However, further in vivo and in vitro investigations are still needed to elucidate the mechanisms of DXK on regulating cerebral blood vessels.
C1 [Li, Ning; Fan, Fangfang; Meng, Xianli; Zhang, Yi] Chengdu Univ Tradit Chinese Med, Sch Ethn Med, Chengdu 611137, Peoples R China.
   [Li, Ning; Fan, Fangfang; Wang, Xiaobo; Zhang, Yi] Chengdu Univ Tradit Chinese Med, Ethn Med Acad Heritage Innovat Res Ctr, Chengdu 611137, Peoples R China.
   [Chen, Ke; Bai, Jinrong; Tang, Yan; Hou, Ya; Ai, Xiaopeng] Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 611137, Peoples R China.
   [Geng, Zangjia] Southwest Minzu Univ, Sch Pharm, Chengdu 610041, Peoples R China.
   [Hu, Yao] Chengdu Univ Tradit Chinese Med, Interdisciplinary Lab Exercise & Med, Chengdu 611137, Sichuan, Peoples R China.
   [Meng, Xianli; Wang, Xiaobo] Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Chengdu 611137, Peoples R China.
   [Zhang, Yi] Chengdu Univ Tradit Chinese Med, NMPA Key Lab Qual Evaluat Tradit Chinese Med Trad, Chengdu 611137, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine; Chengdu University of Traditional
   Chinese Medicine; Southwest Minzu University; Chengdu University of
   Traditional Chinese Medicine; Chengdu University of Traditional Chinese
   Medicine; Chengdu University of Traditional Chinese Medicine
RP Zhang, Y (corresponding author), Chengdu Univ Tradit Chinese Med, Ethn Med Acad Heritage Innovat Res Ctr, Chengdu 611137, Peoples R China.; Meng, XL; Wang, XB (corresponding author), Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Chengdu 611137, Peoples R China.
EM xlm999@cdutcm.edu.cn; 1461875871@qq.com; Zhangyi@cdutcm.edu.cn
RI Li, Ning/ACN-2379-2022
OI Li, Ning/0000-0002-2396-1408
FU National Key R&D Program of China [2017YFC1703904]; China Postdoctoral
   Science Foundation [2020M683273]; National Natural Science Foundation of
   China [81973569]; State Administration of Traditional Chinese Medicine
   of the People's Republic of China [201507002]; Major Science and
   Technology Project of Sichuan Science and Technology Department
   [19SYXHZ0095]; Science and Technology Department of Sichuan Province
   [21YYJC0173]; Project First-Class Disciplines Development of Chengdu
   University of Traditional Chinese Medicine [CZYJC1903]; Xinglin Scholar
   Research Premotion Project of Chengdu University of TCM [CXTD2018015,
   CXTD2018020]; State Key Laboratory of Characteristic Chinese Medicine
   Resources in Southwest China [2020XSGG004]
FX This study was supported by National Key R&D Program of China
   (2017YFC1703904), the project funded by China Postdoctoral Science
   Foundation (2020M683273), the National Natural Science Foundation of
   China (81973569), State Administration of Traditional Chinese Medicine
   of the People's Republic of China (201507002), the Major Science and
   Technology Project of Sichuan Science and Technology Department
   (19SYXHZ0095), Project of Science and Technology Department of Sichuan
   Province (21YYJC0173), Project First-Class Disciplines Development of
   Chengdu University of Traditional Chinese Medicine (CZYJC1903), and
   Xinglin Scholar Research Premotion Project of Chengdu University of TCM
   (CXTD2018015 and CXTD2018020), and the State Key Laboratory of
   Characteristic Chinese Medicine Resources in Southwest China
   (2020XSGG004).
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NR 95
TC 25
Z9 27
U1 5
U2 62
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
EI 1872-7573
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD APR 24
PY 2021
VL 270
AR 113629
DI 10.1016/j.jep.2020.113629
EA JAN 2021
PG 13
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA QH8OK
UT WOS:000618531500004
PM 33246120
DA 2026-05-27
ER

PT J
AU Elgendy, SA
   Soliman, MM
   Ghamry, HI
   Shukry, M
   Mohammed, LA
   Nasr, HE
   Alotaibi, BS
   Jafri, I
   Sayed, S
   Osman, A
   Elnoury, HA
AF Elgendy, Salwa A.
   Soliman, Mohamed Mohamed
   Ghamry, Heba I.
   Shukry, Mustafa
   Mohammed, Lina Abdelhady
   Nasr, Hend Elsayed
   Alotaibi, Badriyah S.
   Jafri, Ibrahim
   Sayed, Samy
   Osman, Amira
   Elnoury, Heba A.
TI Exploration of Tilmicosin Cardiotoxicity in Rats and the Protecting Role
   of the Rhodiola rosea Extract: Potential Roles of Cytokines,
   Antioxidant, Apoptotic, and Anti-Fibrotic Pathways
SO TOXICS
LA English
DT Article
DE cardiomyopathy; tilmicosin; Rhodiola rosea; antioxidants; oxidative
   stress; apoptosis
ID OXIDATIVE STRESS; INTERFERON-GAMMA; GENE-EXPRESSION; L-CARNITINE;
   DNA-DAMAGE; IN-VITRO; CARVEDILOL; DOXORUBICIN; SALIDROSIDE; INFECTIONS
AB Tilmicosin (TIL) is a common macrolide antibiotic in veterinary medicine. High doses of TIL can have adverse cardiovascular effects. This study examined the effects of Rhodiola rosea (RHO) that have anti-inflammatory, antioxidant, and anti-fibrotic effects on tilmicosin (TIL)-induced cardiac injury targeting anti-inflammatory, antioxidant, apoptotic, and anti-apoptotic signaling pathways with anti-fibrotic outcomes. Thirty-six male Wistar albino rats were randomly divided into groups of six rats each. Rats received saline as a negative control, CARV 1 mL orally (10 mg/kg BW), and RHO 1 mL orally at 400 mg/kg BW daily for 12 consecutive days. The TIL group once received a single subcutaneous injection (SC) dose of TIL (75 mg/kg BW) on the sixth day of the experiment to induce cardiac damage. The standard group (CARV + TIL) received CARV daily for 12 consecutive days with a single TIL SC injection 1 h after CARV administration only on the sixth day of study and continued for another six successive days on CARV. The protective group (RHO + TIL) received RHO daily for the same period as in CARV + TIL-treated rats and with the dosage mentioned before. Serum was extracted at the time of the rat's scarification at 13 days of study and examined for biochemical assessments in serum lactate dehydrogenase (LDH), cardiac troponin I (cTI), and creatine phosphokinase (CK-MB). Protein carbonyl (PC) contents, malondialdehyde (MDA), and total antioxidant capacity (TAC) in cardiac homogenate were used to measure these oxidative stress markers. Quantitative RT-PCR was used to express interferon-gamma (INF-gamma), cyclooxygenase-2 (COX-2), OGG1, BAX, caspase-3, B-cell lymphoma-2 (Bcl-2), and superoxide dismutase (SOD) genes in cardiac tissues, which are correlated with inflammation, antioxidants, and apoptosis. Alpha-smooth muscle actin (alpha-SMA), calmodulin (CaMKII), and other genes associated with Ca2+ hemostasis and fibrosis were examined using IHC analysis in cardiac cells (myocardium). TIL administration significantly increased the examined cardiac markers, LDH, cTI, and CK-MB. TIL administration also increased ROS, PC, and MDA while decreasing antioxidant activities (TAC and SOD mRNA) in cardiac tissues. Serum inflammatory cytokines and genes of inflammatory markers, DNA damage (INF-gamma, COX-2), and apoptotic genes (caspase-3 and BAX) were upregulated with downregulation of the anti-apoptotic gene Bcl-2 as well as the DNA repair OGG1 in cardiac tissues. Furthermore, CaMKII and alpha-SMA genes were upregulated at cellular levels using cardiac tissue IHC analysis. On the contrary, pretreatment with RHO and CARV alone significantly decreased the cardiac injury markers induced by TIL, inflammatory and anti-inflammatory cytokines, and tissue oxidative-antioxidant parameters. INF-gamma, COX-2, OGG1, BAX, and caspase-3 mRNA were downregulated, as observed by real-time PCR, while SOD and Bcl-2 mRNA were upregulated. Furthermore, the CaMKII and alpha-SMA genes' immune reactivities were significantly decreased in the RHO-pretreated rats.
C1 [Elgendy, Salwa A.; Elnoury, Heba A.] Benha Univ, Fac Med, Dept Otorhinolaryngol, Banha 13511, Egypt.
   [Soliman, Mohamed Mohamed] Taif Univ, Turabah Univ Coll, Dept Clin Lab Sci, POB 11099, Taif 21944, Saudi Arabia.
   [Soliman, Mohamed Mohamed] Benha Univ, Fac Vet Med, Biochem Dept, Toukh 13736, Egypt.
   [Ghamry, Heba I.] King Khalid Univ, Fac Home Econ, Dept Home Econ, Nutr & Food Sci, POB 960, Abha 61421, Saudi Arabia.
   [Shukry, Mustafa] Kafrelsheikh Univ, Fac Vet Med, Dept Physiol, Kafrelsheikh 33516, Egypt.
   [Mohammed, Lina Abdelhady; Nasr, Hend Elsayed] Benha Univ, Fac Med, Dept Med Biochem & Mol Biol, Banha 13511, Egypt.
   [Alotaibi, Badriyah S.] Princess Nourah Bint Abdulrahman Univ, Coll Pharm, Dept Pharmaceut Sci, POB 84428, Riyadh 11671, Saudi Arabia.
   [Jafri, Ibrahim] Taif Univ, Coll Sci, Dept Biotechnol, POB 11099, Taif 21944, Saudi Arabia.
   [Sayed, Samy] Cairo Univ, Fac Agr, Dept Econ Entomol & Pesticides, Giza 12613, Egypt.
   [Sayed, Samy] Taif Univ, Univ Coll Ranyah, Dept Sci & Technol, POB 11099, Taif 21944, Saudi Arabia.
   [Osman, Amira] Zarqa Univ, Fac Dent, Dept Basic Med & Dent Sci, Zarqa 13110, Jordan.
   [Osman, Amira] Kafrelsheikh Univ, Fac Med, Dept Histol & Cell Biol, Kafrelsheikh 33516, Egypt.
C3 Egyptian Knowledge Bank (EKB); Benha University; Taif University;
   Egyptian Knowledge Bank (EKB); Benha University; King Khalid University;
   Egyptian Knowledge Bank (EKB); Kafrelsheikh University; Egyptian
   Knowledge Bank (EKB); Benha University; Princess Nourah bint Abdulrahman
   University; Taif University; Egyptian Knowledge Bank (EKB); Cairo
   University; Taif University; Zarqa University; Egyptian Knowledge Bank
   (EKB); Kafrelsheikh University
RP Shukry, M (corresponding author), Kafrelsheikh Univ, Fac Vet Med, Dept Physiol, Kafrelsheikh 33516, Egypt.; Alotaibi, BS (corresponding author), Princess Nourah Bint Abdulrahman Univ, Coll Pharm, Dept Pharmaceut Sci, POB 84428, Riyadh 11671, Saudi Arabia.
EM mmsoliman@tu.edu.sa; hgmry@kku.edu.sa; mostafa.ataa@vet.kfs.edu.eg;
   hend.mosalm@fmed.bu.edu.eg; bsalotaibi@pnu.edu.sa;
   samy_mahmoud@hotmail.com; mero.osman@med.kfs.edu.eg
RI Mohammed, A.B./M-5736-2017; Jafri, Ibrahim/JZK-8099-2024; Ghamry,
   Heba/AFQ-2276-2022; Sayed, Samy/AAD-2389-2020; Soliman, Mohamed
   Mohamed/ABJ-0997-2022; Osman, Amira/ABE-2431-2021; Shukry,
   Mustafa/AAB-9324-2019
OI Sayed, Samy/0000-0002-7002-568X; Jafri, Ibrahim/0000-0002-8465-6829;
   Soliman, Mohamed Mohamed/0000-0001-7208-7123; Alotaibi, Baiyah
   Shadid/0000-0002-4066-5694; Shukry, Mustafa/0000-0003-2722-2466
FU The authors thank the Pharmacology, Pathology, and Clinical Pathology
   Departments, Faculty of Medicine at Benha University, Egypt, for their
   invaluable technical and administrative support throughout this work.
   The authors would like to thank King Khalid U; Clinical Pathology
   Departments, Faculty of Medicine at Benha University [RGP2/435/44,
   PNURSP2023R73]; King Khalid University's Deanship of Scientific Research
   for the Large Group Research Project; Princess Nourah bint Abdulrahman
   University, Riyadh, Saudi Arabia
FX The authors thank the Pharmacology, Pathology, and Clinical Pathology
   Departments, Faculty of Medicine at Benha University, Egypt, for their
   invaluable technical and administrative support throughout this work.
   The authors would like to thank King Khalid University's Deanship of
   Scientific Research for the Large Group Research Project (Grant number
   RGP2/435/44). We appreciate the resources provided by Princess Nourah
   bint Abdulrahman University Researchers Supporting Project number
   (PNURSP2023R73), Princess Nourah bint Abdulrahman University, Riyadh,
   Saudi Arabia.
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NR 80
TC 5
Z9 5
U1 0
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2305-6304
J9 TOXICS
JI Toxics
PD OCT
PY 2023
VL 11
IS 10
AR 857
DI 10.3390/toxics11100857
PG 22
WC Environmental Sciences; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Toxicology
GA W6HF2
UT WOS:001092609900001
PM 37888707
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Han, LZ
   Wu, LY
   Yin, QN
   Li, L
   Zheng, XY
   Du, S
   Huang, XF
   Bai, L
   Wang, Y
   Bian, Y
AF Han, Lizhu
   Wu, Liuyun
   Yin, Qinan
   Li, Lian
   Zheng, Xingyue
   Du, Shan
   Huang, Xuefei
   Bai, Lan
   Wang, Yi
   Bian, Yuan
TI A promising therapy for fatty liver disease: PCSK9 inhibitors
SO PHYTOMEDICINE
LA English
DT Article
DE Fatty liver disease (fld); Nonalcoholic fatty liver disease (nafld);
   Alcoholic fatty liver disease (afld); Proprotein convertase subtilisin/
   kexin type 9 (pcsk9); PCSK9 inhibitor; traditional Chinese medicine
ID SUBTILISIN/KEXIN TYPE 9; LIPOPROTEIN RECEPTOR LDLR; CELL-SURFACE LDLR;
   HEPATIC STEATOSIS; GENE-EXPRESSION; TANSHINONE IIA; NONALCOHOLIC
   STEATOHEPATITIS; PROBABLE INTERACTION; CIRCULATING PCSK9; REDUCING
   LIPIDS
AB Background: Fatty liver disease (FLD) poses a significant global health concern worldwide, with its classification into nonalcoholic fatty liver disease (NAFLD) and alcoholic fatty liver disease (AFLD) contingent upon the presence or absence of chronic and excessive alcohol consumption. The absence of specific therapeutic interventions tailored to FLD at various stages of the disease renders its treatment exceptionally arduous. Despite the fact that FLD and hyperlipidemia are intimately associated, there is still debate over how lipid-lowering medications affect FLD. Proprotein Convertase Subtilisin/ Kexin type 9 (PCSK9) is a serine protease predominantly synthesized in the liver, which has a crucial impact on cholesterol homeostasis. Research has confirmed that PCSK9 inhibitors have prominent lipid-lowering properties and substantial clinical effectiveness, thereby justifying the need for additional exploration of their potential role in FLD. Purpose: Through a comprehensive literature search, this review is to identify the relationship and related mechanisms between PCSK9, lipid metabolism and FLD. Additionally, it will assess the pharmacological mechanism and applicability of PCSK9 inhibitors (including naturally occurring PCSK9 inhibitors, such as conventional herbal medicines) for the treatment of FLD and serve as a guide for updating the treatment protocol for such conditions. Methods: A comprehensive literature search was conducted using several electronic databases, including Pubmed, Medline, Embase, CNKI, Wanfang database and ClinicalTrials.gov, from the inception of the database to 30 Jan 2024. Key words used in the literature search were "fatty liver", "hepatic steatosis", "PCSK9", "traditional Chinese medicine", "herb medicine", "botanical medicine", "clinical trial", "vivo", "vitro", linked with AND/OR. Most of the included studies were within five years. Results: PCSK9 participates in the regulation of circulating lipids via both LDLR dependent and independent pathways, and there is a potential association with de novo lipogenesis. Major clinical studies have demonstrated a positive correlation between circulating PCSK9 levels and the severity of NAFLD, with elevated levels of circulating PCSK9 observed in individuals exposed to chronic alcohol. Numerous studies have demonstrated the potential of PCSK9 inhibitors to ameliorate non-alcoholic steatohepatitis (NASH), potentially completely alleviate liver steatosis, and diminish liver impairment. In animal experiments, PCSK9 inhibitors have exhibited efficacy in alleviating alcoholic induced liver lipid accumulation and hepatitis. Traditional Chinese medicine such as berberine, curcumin, resveratrol, piceatannol, sauchinone, lupin, quercetin, salidroside, ginkgolide, tanshinone, lunasin, Capsella bursa-pastoris, gypenosides, and Morus alba leaves are the main natural PCS9 inhibitors. Excitingly, by inhibiting transcription, reducing secretion, direct targeting and other pathways, traditional Chinese medicine exert inhibitory effects on PCSK9, thereby exerting potential FLD therapeutic effects. Conclusion: PCSK9 plays an important role in the development of FLD, and PCSK9 inhibitors have demonstrated beneficial effects on lipid regulation and FLD in both preclinical and clinical studies. In addition, some traditional Chinese medicines have improved the disease progression of FLD by inhibiting PCSK9 and anti-inflammatory and antioxidant effects. Consequently, the inhibition of PCSK9 appears to be a promising therapeutic strategy for FLD.
C1 [Han, Lizhu; Wu, Liuyun; Yin, Qinan; Li, Lian; Zheng, Xingyue; Du, Shan; Huang, Xuefei; Bai, Lan; Bian, Yuan] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Dept Pharm, Chengdu 610072, Peoples R China.
   [Han, Lizhu; Yin, Qinan; Du, Shan; Huang, Xuefei; Bai, Lan; Bian, Yuan] Univ Elect Sci & Technol China, Sch Med, Personalized Drug Therapy Key Lab Sichuan Prov, Chengdu 610072, Peoples R China.
   [Wang, Yi] Sichuan Acad Med Sci & Sichuan Prov Peoples Hosp, Ctr Organ Transplantat, Clin Immunol Translat Med Key Lab Sichuan Prov, Chengdu 610072, Peoples R China.
   [Bai, Lan; Wang, Yi; Bian, Yuan] 32,West Sect 2,1st Ring Rd, Chengdu, Sichuan, Peoples R China.
C3 University of Electronic Science & Technology of China; Sichuan
   Provincial People's Hospital; University of Electronic Science &
   Technology of China; Sichuan Provincial People's Hospital
RP Bai, L; Wang, Y; Bian, Y (corresponding author), 32,West Sect 2,1st Ring Rd, Chengdu, Sichuan, Peoples R China.
EM blci@163.com; w_yi2022@163.com; bianyuan567@126.com
RI Bian, Yuan/JWA-4495-2024; yin, qinan/AAC-1140-2019; du,
   shan/JNS-8863-2023; Bai, Lan/PJA-9238-2026; Han, Liizhu/KDO-4646-2024
OI Bian, Yuan/0000-0003-2365-9177; 
FU National Key Research and Develop- ment Program of China
   [2020YFC2005500]; Natural Science Foundation of Sichuan Province
   [2022NSFSC0818]
FX <BOLD>Fundings</BOLD> This work has been funded by National Key Research
   and Develop- ment Program of China (2020YFC2005500) , and the Natural
   Science Foundation of Sichuan Province (2022NSFSC0818) .
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NR 173
TC 19
Z9 24
U1 3
U2 37
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD JUN
PY 2024
VL 128
AR 155505
DI 10.1016/j.phymed.2024.155505
EA MAR 2024
PG 20
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA QA2S1
UT WOS:001218100600001
PM 38547616
OA hybrid
DA 2026-05-27
ER

PT J
AU Hou, Y
   Fan, FH
   Xie, N
   Zhang, Y
   Wang, XB
   Meng, XL
AF Hou, Ya
   Fan, Fuhan
   Xie, Na
   Zhang, Yi
   Wang, Xiaobo
   Meng, Xianli
TI Rhodiola crenulata alleviates hypobaric hypoxia-induced brain
   injury by maintaining BBB integrity and balancing energy metabolism
   dysfunction
SO PHYTOMEDICINE
LA English
DT Article
DE Rhodiola crenulata; Hypobaric hypoxia-induced brain injury; BBB
   integrity; Energy metabolism
ID ISCHEMIA-REPERFUSION INJURY; SUBARACHNOID HEMORRHAGE; RAT-BRAIN;
   MITOCHONDRIAL; INHIBITION; LIVER; PATHWAY; BARRIER; STRESS
AB Background/Purpose: : Rhodiola crenulata (Hook. f. et Thoms.) H. Ohba ( R. crenulate ), a famous and characteristic Tibetan medicine, has been demonstrated to exert an outstanding brain protection role in the treatment of highaltitude hypoxia disease. However, the metabolic effects of R. crenulate on high-altitude hypoxic brain injury (HHBI) are still incompletely understood. Herein, the anti-hypoxic effect and associated mechanisms of R. crenulate were explored through both in vivo and in vitro experiments. Study design/Methods: The mice model of HHBI was established using an animal hypobaric and hypoxic chamber. R. crenulate extract (RCE, 0.5, 1.0 and 2.0 g/kg) and salidroside (Sal, 25, 50 and 100 mg/kg) was given by gavage for 7 days. Pathological changes and neuronal apoptosis of mice hippocampus and cortex were evaluated using H &E and TUNEL staining, respectively. The effects of RCE and Sal on the permeability of blood brain barrier (BBB) were detected by Evans blue staining and NIR-II fluorescence imaging. Meanwhile, the ultrastructural BBB and cerebrovascular damages were observed using a transmission electron microscope (TEM). The levels of tight junction proteins Claudin-1, ZO-1 and occludin were detected by immunofluorescence. Additionally, the metabolites in mice serum and brain were determined using UHPLC-MS and MALDI-MSI analysis. The cell viability of Sal on hypoxic HT22 cells induced by CoCl 2 was investigated by cell counting kit-8. The contents of LDH, MDA, SOD, GSH-PX and SDH were detected by using commercial biochemical kits. Meanwhile, intracellular ROS, Ca 2 + and mitochondrial membrane potential were determined by corresponding specific labeled probes. The intracellular metabolites of HT22 cells were performed by the targeted metabolomics analysis of the Q300 kit. The cell apoptosis and necrosis were examined by YO-PRO-1/PI, Annexin V/PI and TUNEL staining. In addition, mitochondrial morphology was tested by Mito-tracker red with confocal microscopy and TEM. Realtime ATP production, oxygen consumption rate, and proton efflux rate were measured using a Seahorse analyzer. Subsequently, MCU, OPA1, p-Drp1ser616, p-AMPK alpha, p-AMPK beta and Sirt1 were determined by immunofluorescent and western blot analyses. Results: The results demonstrated that R. crenulate and Sal exert anti-hypoxic brain protection from inhibiting neuronal apoptosis, maintaining BBB integrity, increasing tight junction protein Claudin-1, ZO-1 and occludin and improving mitochondrial morphology and function. Mechanistically, R. crenulate and Sal alleviated HHBI by enhancing the tricarboxylic acid cycle to meet the demand of energy of brain. Additionally, experiments in vitro confirmed that Sal could ameliorate the apoptosis of HT22 cells, improve mitochondrial morphology and energy metabolism by enhancing mitochondrial respiration and glycolysis. Meanwhile, Sal-mediated MCU inhibited the activation of Drp1 and enhanced the expression of OPA1 to maintain mitochondrial homeostasis, as well as activation of AMPK and Sirt1 to enhance ATP production. Conclusion: Collectively, the findings suggested that RCE and Sal may afford a protective intervention in HHBI through maintaining BBB integrity and improving energy metabolism via balancing MCU-mediated mitochondrial homeostasis by activating the AMPK/Sirt1 signaling pathway.
C1 [Hou, Ya; Fan, Fuhan; Xie, Na; Zhang, Yi; Meng, Xianli] Chengdu Univ Tradit Chinese Med, Sch Pharm, Sch Modern Chinese Med Ind, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China.
   [Wang, Xiaobo; Meng, Xianli] Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Acad Interdiscipline, Chengdu 611137, Peoples R China.
   [Wang, Xiaobo; Meng, Xianli] Chengdu Univ Tradit Chinese Med, Meishan Hosp, Meishan 620010, Peoples R China.
   [Wang, Xiaobo; Meng, Xianli] 1166 Liutai Ave, Chengdu 611137, Sichuan, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine; Chengdu University of Traditional
   Chinese Medicine
RP Wang, XB; Meng, XL (corresponding author), 1166 Liutai Ave, Chengdu 611137, Sichuan, Peoples R China.
EM VitaDrwang@cdutcm.edu.cn; xlm999@cdutcm.edu.cn
FU National Natural Science Foundation of China [82274207, 82104533,
   U23A20520]; Science & Tech-nology Department of Sichuan Province
   [24NSFSC5095]; Key Research and Development Program of Ningxia
   [2023BEG02012]; Xinglin Scholar Research Promotion Project of Chengdu
   University of TCM [QJRC2023037, XKTD2022013]
FX Funding statement This work was supported by the National Natural
   Science Foundation of China (82274207, 82104533 and U23A20520) , the
   Science & Tech-nology Department of Sichuan Province (24NSFSC5095) , the
   Key Research and Development Program of Ningxia (2023BEG02012) and the
   Xinglin Scholar Research Promotion Project of Chengdu University of TCM
   (QJRC2023037 and XKTD2022013) .
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NR 83
TC 78
Z9 90
U1 25
U2 233
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD JUN
PY 2024
VL 128
AR 155529
DI 10.1016/j.phymed.2024.155529
EA MAR 2024
PG 22
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA RG9V4
UT WOS:001226640200001
PM 38503156
DA 2026-05-27
ER

PT J
AU Yan, D
   Zhao, LL
   Yue, BW
   Qian, H
   Zhang, ZH
   Wang, N
   Yan, SH
   Qian, YL
AF Yan, Dong
   Zhao, Li-li
   Yue, Bo-wen
   Qian, Hui
   Zhang, Zi-han
   Wang, Ning
   Yan, Shi-hai
   Qian, Yu-liang
TI Granule of BU-XIN RUAN-MAI Attenuates the Patients' Angina Pectoris of
   Coronary Heart Disease via Regulating miR-542-3p/GABARAP Signaling
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID OPHIOPOGON-JAPONICUS; RHODIOLA-ROSEA; GINKGO-BILOBA; ENDOTHELIAL-CELLS;
   AUTOPHAGY; APOPTOSIS; EXTRACT; CONSTITUENTS; MEDICATIONS; INHIBITION
AB Objective. Coronary heart disease (CHD) has been regarded as a serious and common disease in the modern society. This study aims to investigate the effect of Granule of BU-XIN RUAN-MAI (BXRM) on angina pectoris of coronary heart disease and to explore the molecular mechanisms underlying Granule of BU-XIN RUAN-MAI-mediated protective activity against this disease. Methods. The effects of Granule of BU-XIN RUAN-MAI on clinical symptoms of patients' angina were indicated by hemorheology indicators including high shear of blood viscosity, low shear of blood viscosity, plasma viscosity, erythrocyte rigidity index, D-D dimer, fibrinogen content, and lipid content. The effects of Granule of BU-XIN RUAN-MAI on isoprenaline-induced myocardial cell injury were determined by conducting H&E staining and by performing ELISA to examine the serum content of MDA, SOD, Na+/K+-ATPase, cAMP, and the content of inflammatory factors in isoprenaline-induced rats. Meanwhile, western blot and real time PCR were used to determine the expression of genes involved in oxidation and energy metabolism, and real time PCR was also used for determination of miR-542-3p expression. Luciferase reporter assay was conducted to test the binding sites of miR-542-3p on GABARAP 3 ' UTR. The chemical compositions of Granule of BU-XIN RUAN-MAI were determined by liquid LC-QTOF-MS. Results. Granule of BU-XIN RUAN-MAI significantly attenuated the clinical symptoms of patients' angina by improving the patients' heart rate and by decreasing the level of hemorheology indicators and also by reducing the serum content of TC, TG, LDL, and elevated HDL content. H&E staining demonstrated that Granule of BU-XIN RUAN-MAI ameliorated the myocardial ischemia in a dose-dependent manner. Besides, Granule of BU-XIN RUAN-MAI downregulated serum MDA content and upregulated the content of SOD, Na+/K+-ATPase, and cAMP in isoprenaline-induced rats. Granule of BU-XIN RUAN-MAI significantly improved oxidation stress by increasing PPAR alpha expression, and it inhibited inflammation by downregulating expression and contents of IL-6, IL-1 beta, and TNF-alpha. Then, Granule of BU-XIN RUAN-MAI-containing serum increased the SOD content, and reduced the MDA content in angiotensin II-stimulated HUVEC cells. The granule of BU-XIN RUAN-MAI-containing serum obviously downregulated protein expressions of P40phox, P47phox, and P67phox in plasma membrane, and it significantly increased protein levels of P40phox, P47phox, and P67phox in the cytoplasm of HUVEC cells. Furthermore, GABARAP was reduced in heart tissues of ISO-induced rats and in angiotensin II-stimulated cell lines, and GABARAP was required for the inhibitory activity of Granule of BU-XIN RUAN-MAI on oxidation and inflammation in vivo and in vivo. GABARAP could be upregulated by Granule of BU-XIN RUAN-MAI by inhibiting the expression of miR-542-3p, which may significantly enhance oxidation and inflammation by targeting GABARAP in cardiomyocytes. Moreover, the silencing of GABARAP could obviously reverse the granule of BU-XIN RUAN-MAI-mediated protective activity against coronary heart disease, and interfering GABARAP expression also could partly block the anti-miR-542-3p-controlled oxidation and inflammation in cardiomyocytes. Besides, salidroside, loganin, and polydatin were the main compounds of granules of BU-XIN RUAN-MAI. Conclusion. Granule of BU-XIN RUAN-MAI is an excellent prescription for treatment of coronary heart disease by suppressing inflammation and NAPDH-mediated oxidative stress.
   The miR-542-3p/GABARAP axis is required for Granule of BU-XIN RUAN-MAI, exhibiting its protective activity against the pectoris of coronary heart disease.
C1 [Yan, Dong; Yan, Shi-hai; Qian, Yu-liang] Nanjing Univ TCM, Dept Pharmacol, Affiliated Hosp, Nanjing, Peoples R China.
   [Yan, Dong; Zhao, Li-li; Yue, Bo-wen; Qian, Hui; Zhang, Zi-han; Wang, Ning; Yan, Shi-hai; Qian, Yu-liang] Nanjing Univ TCM, Nanjing, Peoples R China.
C3 Nanjing University of Chinese Medicine; Nanjing University of Chinese
   Medicine
RP Yan, SH; Qian, YL (corresponding author), Nanjing Univ TCM, Dept Pharmacol, Affiliated Hosp, Nanjing, Peoples R China.; Yan, SH; Qian, YL (corresponding author), Nanjing Univ TCM, Nanjing, Peoples R China.
EM sea-y@qq.com; drqyl1972@163.com
RI Wang, Ning/JTT-2198-2023; Yan, Shihai/NHQ-4125-2025; zhang,
   zihan/JHU-2592-2023; Qian, Yuliang/OFN-7165-2025
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NR 70
TC 14
Z9 15
U1 2
U2 12
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PD DEC 27
PY 2019
VL 2019
DI 10.1155/2019/1808419
PG 20
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA KA7CJ
UT WOS:000505954500002
PM 31949464
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Lieshchova, M
   Brygadyrenko, V
AF Lieshchova, Maryna
   Brygadyrenko, Viktor
TI Effect of Rhodiola rosea Rhizome and Punica granatum Fruit
   Peel on the Metabolic Processes and Physiological Activity of Rats Fed
   with Excessively Fat Diet
SO FOOD TECHNOLOGY AND BIOTECHNOLOGY
LA English
DT Article
DE high-fat diet; body mass increase; obesity correction; golden root
   rhizome; pomegranate peel; atherogenic index of plasma
ID POMEGRANATE JUICE; OFFICINALIS; SALIDROSIDE
AB Research background. Rhodiola rosea (golden root) and Punica granatum (pomegranate), as well as a number of other species of medicinal plants, exert an array of biological effects: adaptogenic, antioxidant and anti-inflammatory. However, there are not enough contemporary studies of their influence on metabolic processes, especially in cases of imbalanced diet. Lipid dysregulation is the main reason for many diseases, including obesity, cardiovascular disorders, non-alcoholic fatty liver disease, hypertension, atherosclerosis and insulin resistance. Recently, a growing amount of evidence has suggested the positive effects of certain natural nutrients on lipid metabolism. This work aims to define the general effect of golden root rhizome and pomegranate peel on physiological activity and metabolic processes in model animals fed with excessively fat diet. This study is relevant for the development of drugs and food additives for treatment and prophylaxis of metabolism disorders.
   Experimental approach. In a 30-day experiment, we determined the effect of golden root (Rhodiola rosea L.) rhizome and pomegranate (Punica granatum L.) peel on the physiological activity and metabolic processes of 24 laboratory rats consuming a high-fat diet. The physical activity was evaluated according to the mass gain of animals and change in the relative mass of the internal organs, and also the functional conditions of the central nervous system, as demonstrated by the indicators of the locomotor activity and emotional status, determined in the open field test. The influence on the metabolic processes was revealed by biochemical and clinical blood analyses.
   Results and conclusions. Body mass of rats fed with golden root (R. rosea) reached 125.8 % of the initial body mass; when fed on pomegranate (P. granatum), it reached 123.9 %; and the control group reached only 111.5 % of the initial body mass. The rhizomes of R. rosea in the diet of male rats during the month of the experiment did not cause significant changes in the relative organ mass, and the pomegranate peel fruits led to a decrease in the thymus relative mass, as well as liver and brain. R. rosea rhizomes in the rats' diet led to an increase in the activity of alkaline phosphatase, and also to a decrease in the concentration of urea and urea nitrogen. Diet supplemented with R. rosea also contributed to a strong decrease in plasma concentrations of bilirubin and triglycerides (up to 57.0 % compared with the concentration in the control group). The rhizomes of R. rosea contributed to an unreliable decrease in the atherogenicity index. The pomegranate peel also greatly increased alkaline phosphatase activity and reduced plasma triglyceride concentrations. In addition, in rats consuming the peel of P. granatum, blood glucose concentration decreased. Under the influence of P. granatum, a strong increase in the atherogenic index of plasma (up to 518.6 % of the control) was observed because of a decrease in the concentration of high-density lipoproteins (up to 57.1 %) and a simultaneous elevation of the concentration of low-density lipoproteins (up to 158.3 % of the control). Open field test between groups remained without significant changes.
   Novelty and scientific contribution. The results indicate that the rhizome of R. rosea and peel of P. granatum are safe as food additives to high-fat diet and did not cause pathological changes and side effects, and at the same time significantly influence the metabolic processes (lipid and carbohydrate). Our study theoretically substantiates the use of R. rosea rhizome and P. granatum peel for the production of nutraceutical and pharmacological products for the correction of metabolic disorders of people and animals. Doses and periods of their application require further research.
C1 [Lieshchova, Maryna; Brygadyrenko, Viktor] Dnipro State Agrarian & Econ Univ, Dept Anat Histol & Pathomorphol Anim, Sergiy Efremov St 25, UA-49000 Dnipro, Ukraine.
   [Brygadyrenko, Viktor] Oles Honchar Dnipro Natl Univ, Dept Zool & Ecol, Gagarin Ave 72, UA-49010 Dnipro, Ukraine.
C3 Ministry of Education & Science of Ukraine; Dnipro State Agrarian and
   Economic University; Ministry of Education & Science of Ukraine; Oles
   Honchar Dnipro National University
RP Lieshchova, M; Brygadyrenko, V (corresponding author), Dnipro State Agrarian & Econ Univ, Dept Anat Histol & Pathomorphol Anim, Sergiy Efremov St 25, UA-49000 Dnipro, Ukraine.; Brygadyrenko, V (corresponding author), Oles Honchar Dnipro Natl Univ, Dept Zool & Ecol, Gagarin Ave 72, UA-49010 Dnipro, Ukraine.
EM lieshchova.m.o@dsau.dp.ua; brigad@ua.fm
RI Lieshchova, Maryna/D-8371-2019; Brygadyrenko, Viktor/B-7287-2015
OI Lieshchova, Maryna/0000-0002-4251-4152; Brygadyrenko,
   Viktor/0000-0002-9448-8232
FU Ministry of Education and Science of Ukraine [0122U000975]
FX This research was funded by the Ministry of Education and Science of
   Ukraine, grant number 0122U000975.
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NR 44
TC 8
Z9 8
U1 2
U2 6
PU FACULTY FOOD TECHNOLOGY BIOTECHNOLOGY
PI ZAGREB
PA UNIV ZAGREB, KACIECEVA 23, 41000 ZAGREB, CROATIA
SN 1330-9862
EI 1334-2606
J9 FOOD TECHNOL BIOTECH
JI Food Technol. Biotechnol.
PD APR-JUN
PY 2023
VL 61
IS 2
BP 202
EP 211
DI 10.17113/ftb.61.02.23.7913
PG 10
WC Biotechnology & Applied Microbiology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Food Science & Technology
GA U5ZH7
UT WOS:001085578800005
PM 37457904
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Ren, X
   Hu, R
   Zhang, H
AF Ren, Xing
   Hu, Rong
   Zhang, Hui
TI A Mendelian analysis of the causality between inflammatory cytokines and
   digestive tract cancers
SO POSTGRADUATE MEDICAL JOURNAL
LA English
DT Article
DE inflammatory cytokines; digestive tract cancers; Mendelian
   randomization; GWAS; molecular docking
ID COLORECTAL-CANCER; GROWTH-FACTOR; EXPRESSION; RANDOMIZATION;
   INTERLEUKIN-7; IL-7; IRINOTECAN
AB Purpose In this study, we performed a two-sample Mendelian randomization (MR) analysis to assess the causality between inflammatory cytokines and the risk of digestive tract cancers (DTCs). Furthermore, we conducted a molecular docking study to predict the therapeutic mechanisms of traditional Chinese medicine (TCM) compounds in the treatment of DTCs.Methods In our MR analysis, genetic variations associated with eight types of DTCs were utilized, which were sourced from a large publicly available genome-wide association study dataset (7929 cases and 1 742 407 controls of European ancestry) and inflammatory cytokines data from a genome-wide association study summary of 8293 European participants. Inverse-variance weighted method, MR-Egger, and weighted median were performed to analyze and strengthen the final results. We investigated the effects of 41 inflammatory molecules on 8 types of DTCs. Subsequently, the effect of DTCs on positive inflammatory factors was analyzed by means of inverse MR. Molecular docking was exploited to predict therapeutic targets with TCM compounds.Results Interleukin-7, interleukin-16, macrophage colony-stimulating factor, monokine induced by interferon-gamma, and vascular endothelial growth factor may be significantly associated with various types of DTCs. Five TCM compounds (baicalin, berberine, curcumin, emodin, and salidroside) demonstrated better binding energies to both interleukin-7 and vascular endothelial growth factor than carboplatin.Conclusion This study provides strong evidence to support the potential causality of some inflammatory cytokines on DTCs and indicates the potential molecular mechanism of TCM compounds in the treatment of DTCs. Key message What is already known on this topic The increasing evidence indicates that inflammatory cytokines are implicated in the pathogenesis of digestive tract cancers (DTCs). Nevertheless, the causal relationship between inflammatory cytokines and DTCs remains indistinct. Additionally, certain traditional Chinese medicine compounds have been demonstrated to treat DTCs by influencing inflammatory factors, yet their underlying potential mechanisms remain ambiguous. What this study adds In this study, Mendelian randomization analysis was performed for the first time regarding the causality between human inflammatory cytokines and eight types of DTCs, which revealed that inflammatory factors may play different roles in different types of DTCs. Moreover, molecular docking of key inflammatory factors was implemented, indicating the targets for drug actions. How this study might affect research, practice, or policy This research has the potential to reveal the causality between 41 inflammatory factors and 8 DTCs, offering novel perspectives for the prevention and management strategies of DTCs. Additionally, it indicates the targets for the actions of traditional Chinese medicine on the key inflammatory factors of these cancers.Conclusion This study provides strong evidence to support the potential causality of some inflammatory cytokines on DTCs and indicates the potential molecular mechanism of TCM compounds in the treatment of DTCs. Key message What is already known on this topic The increasing evidence indicates that inflammatory cytokines are implicated in the pathogenesis of digestive tract cancers (DTCs). Nevertheless, the causal relationship between inflammatory cytokines and DTCs remains indistinct.
   Additionally, certain traditional Chinese medicine compounds have been demonstrated to treat DTCs by influencing inflammatory factors, yet their underlying potential mechanisms remain ambiguous. What this study adds In this study, Mendelian randomization analysis was performed for the first time regarding the causality between human inflammatory cytokines and eight types of DTCs, which revealed that inflammatory factors may play different roles in different types of DTCs. Moreover, molecular docking of key inflammatory factors was implemented, indicating the targets for drug actions. How this study might affect research, practice, or policy This research has the potential to reveal the causality between 41 inflammatory factors and 8 DTCs, offering novel perspectives for the prevention and management strategies of DTCs. Additionally, it indicates the targets for the actions of traditional Chinese medicine on the key inflammatory factors of these cancers.
C1 [Ren, Xing; Zhang, Hui] Shanghai Univ Tradit Chinese Med, Inst Interdisciplinary Integrat Med Res, Shanghai 201203, Peoples R China.
   [Hu, Rong] Shanghai Univ Tradit Chinese Med, Inst Sci Technol & Humanities, Shanghai 201203, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Shanghai University
   of Traditional Chinese Medicine
RP Zhang, H (corresponding author), Shanghai Univ Tradit Chinese Med, Inst Interdisciplinary Integrat Med Res, Shanghai 201203, Peoples R China.; Hu, R (corresponding author), Shanghai Univ Tradit Chinese Med, Inst Sci Technol & Humanities, Shanghai 201203, Peoples R China.
EM rstar9797@163.com; hong_hurong@126.com; zhanghuiman@126.com
FU National Natural Science Foundation of China [82074101]; Shanghai
   Municipal Health Commission [202040486]
FX This study was supported by the National Natural Science Foundation of
   China (No. 82074101) and Shanghai Municipal Health Commission
   (202040486).
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NR 56
TC 0
Z9 0
U1 0
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0032-5473
EI 1469-0756
J9 POSTGRAD MED J
JI Postgrad. Med. J.
PD AUG
PY 2025
VL 101
IS 1198
BP 704
EP 715
DI 10.1093/postmj/qgae132
EA OCT 2024
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 5CH3G
UT WOS:001325542000001
PM 39362654
DA 2026-05-27
ER

PT J
AU Guo, LX
   Yi, J
   Zhang, A
   Zheng, XQ
   Wang, M
   Yang, F
   Kong, XB
   Meng, JY
AF Guo, Luxuan
   Yi, Jia
   Zhang, Ao
   Zheng, Xiaoqing
   Wang, Miao
   Yang, Fan
   Kong, Xianbin
   Meng, Jingyan
TI Zhenqi Fuzheng Granule targets the SCFAs-GPR109A axis to enhance PD-1
   antibody efficacy via immunometabolic remodeling in colorectal cancer
SO PHYTOMEDICINE
LA English
DT Article
DE Zhenqi Fuzheng Granule; Immune checkpoint inhibitors; Short-chain fatty
   acids; GPR109A; Immunometabolic remodeling
ID CELLS; SUPPRESSES; GROWTH
AB Background: Immune checkpoint inhibitors (ICIs), particularly PD-1 antibodies, represent a breakthrough in colorectal cancer (CRC) treatment. However, their clinical efficacy remains limited by tumour-induced immunosuppression. Traditional Chinese medicine (TCM) has attracted growing interest as a potential adjuvant to immunotherapy. Zhenqi Fuzheng Granule (ZQFZ) is a clinically approved herbal prescription widely used as an adjuvant therapy for CRC, yet its mechanistic underpinnings remain elusive. Objective: To investigate how ZQFZ improves the efficacy in CRC, with emphasis on gut microbiota modulation, SCFAs production, and downstream immunometabolic pathways involving GPR109A, and confirms that butyrate plays an important role in colorectal cancer inhibition. Methods: Phytochemical analysis of ZQFZ was conducted using LC-MS/MS and UPLC-MS/MS, identifying and quantifying seven major compounds. In vivo experiments, AOM/DSS-induced CRC mouse models were treated with ZQFZ, PD-1 antibody, or their combination. Tumour progression, body weight, and survival were monitored. Gut microbial composition and colonic SCFAs levels were assessed via 16S rRNA sequencing and gas chromatography. RT-qPCR was employed to validate the expression of key genes associated with the GPR109A/ AKT/mTOR/HIF-1 alpha signaling pathway. Molecular changes in the GPR109A/AKT/mTOR/HIF-1 alpha pathway were evaluated through Western blotting, transcriptomic, and proteomic analyses. Immune cell infiltration and phenotypes were analyzed by flow cytometry. Molecular docking and molecular dynamics simulations were conducted to predict the binding affinity and structural stability between GPR109A and AKT1. The interactions between GPR109A and AKT1, as well as between butyrate and GPR109A, were further validated in vitro using microscale thermophoresis (MST) assays. To evaluate the microbial basis of ZQFZ activity, antibiotic-pretreated mice received ZQFZ-derived fecal microbiota transplantation (FMT). In vitro experiments, to investigate the mechanism by which sodium butyrate (NaB), the major gut microbial metabolite of ZQFZ, inhibits glycolysis in colorectal cancer under hypoxic conditions, CCK-8 assays, flow cytometry, lactate measurements, and Western blotting were performed to assess cell viability, apoptosis, lactate production, and the expression of AKT/mTOR/ HIF-1 alpha and glycolysis-related proteins. Results: LC-MS/MS profiling identified multiple bioactive constituents in ZQFZ. Targeted UPLC-MS/MS quantification revealed that the formulation contained Adenosine (0.87mg/g), Salidroside (0.11 mg/g), Astragaloside IV (0.07 mg/g), Calycosin (0.03 mg/g), Formononetin (6.7 mu g /g), Chlorogenic acid (1.4 mu g/g), Apigenin (0.5 mu g/ g). In vivo studies, both ZQFZ and PD-1 antibody inhibited tumour growth, with the combination treatment exerting the most pronounced antitumour effects. ZQFZ reshaped the gut microbiota, increased the levels of short-chain fatty acids (SCFAs), particularly butyrate, and activated the GPR109A pathway, leading to down-regulation of the AKT/mTOR/HIF-1 alpha signaling axis, suppression of HK2 expression and lactate production, and consequent inhibition of glycolysis. Immune remodeling was also observed, including reduced infiltration of myeloid-derived suppressor cells (MDSCs), polarization of macrophages toward the M1 phenotype, restoration of the CD4*/CD8* T cell ratio, and modulation of serum cytokines including upregulation of IL-2, IL-12, and IFN-gamma, along with downregulation of IL-4 and IL-10.
   ZQFZ-derived FMT significantly inhibited tumour growth, suppressed glycolysis-related markers (PKM2, GLUT1, HIF-1 alpha, LDHA), and remodeled the immune microenvironment by reducing MDSCs and enhancing M1 macrophages and CD8+ T cell infiltration. In hypoxia-mimicking in vitro experiments, sodium butyrate (NaB), the principal gut microbial metabolite of ZQFZ, suppressed colorectal cancer cell viability and induced apoptosis. Through activation of GPR109A, NaB inhibited the AKT/mTOR/HIF-1 alpha pathway and glycolysis-related enzymes, reduced lactate production, and further suppressed glycolysis. Molecular docking and dynamics simulations suggested a stable interaction between GPR109A and AKT1, which was confirmed in vitro by MST showing high-affinity binding (Kd=74.5 +/- 20.8 nM); MST also verified moderate-affinity binding between GPR109A and sodium butyrate (Kd=43.3 +/- 6.5 mu M), supporting a dual interaction model wherein butyrate activates GPR109A, which in turn directly binds AKT1 to inhibit downstream glycolytic signaling. Conclusion: This study uncovers a novel integrated mechanism whereby ZQFZ enhances PD-1 antibody efficacy via the gut microbiota-SCFAs-GPR109A axis, and NaB-mediated glycolysis inhibition under hypoxia further confirms its immunometabolic mechanism against CRC.
C1 [Guo, Luxuan; Yi, Jia; Zhang, Ao; Zheng, Xiaoqing; Wang, Miao; Yang, Fan; Kong, Xianbin; Meng, Jingyan] Tianjin Univ Tradit Chinese Med, Coll Tradit Chinese Med, Tianjin 301617, Peoples R China.
   [Guo, Luxuan; Yi, Jia; Zhang, Ao; Zheng, Xiaoqing; Wang, Miao; Yang, Fan; Kong, Xianbin; Meng, Jingyan] Tianjin Univ Tradit Chinese Med, Tianjin Key Lab Modern Chinese Med Theory Innovat, Tianjin 301617, Peoples R China.
   [Guo, Luxuan; Zhang, Ao] Tianjin Univ Tradit Chinese Med, Grad Sch, Tianjin 301617, Peoples R China.
C3 Tianjin University of Traditional Chinese Medicine; Tianjin University
   of Traditional Chinese Medicine; Tianjin University of Traditional
   Chinese Medicine
RP Kong, XB; Meng, JY (corresponding author), Tianjin Univ Tradit Chinese Med, Coll Tradit Chinese Med, Tianjin 301617, Peoples R China.
EM 89kongxianbin@tjutcm.edu.cn; mengjy@163.com
OI Xian-bin, kong/0000-0002-2274-3142; Yi, Jia/0009-0007-3687-8105
FU National Natural Science Foundation of China [82274396]; National
   Natural Science Foundation of China Youth Program [82204962]; Science &
   Technology Development Fund of Tianjin Education Commission for Higher
   Education [2024ZD005]; Science and Technology Program of Tianjin, China
   [22JCQNJC00490]; College Students' Innovation and Entrepreneurship
   Training Program of Tianjin Municipality, China [202410063025]
FX This research was funded by the National Natural Science Foundation of
   China (82274396) ; National Natural Science Foundation of China Youth
   Program (82204962) ; The Science & Technology Development Fund of
   Tianjin Education Commission for Higher Education (2024ZD005) ; Science
   and Technology Program of Tianjin, China (22JCQNJC00490) ; the College
   Students' Innovation and Entrepreneurship Training Program of Tianjin
   Municipality, China (202410063025) .
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NR 87
TC 9
Z9 9
U1 22
U2 31
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD NOV 25
PY 2025
VL 148
AR 157312
DI 10.1016/j.phymed.2025.157312
EA OCT 2025
PG 27
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA 8HB1U
UT WOS:001588493300001
PM 41038145
DA 2026-05-27
ER

PT J
AU Fan, FH
   Chen, M
   Li, YY
   Yan, JR
   Wang, XB
   Zhang, Y
   Zheng, C
   Zhou, J
   Ren, DS
   Meng, XL
   Hou, Y
AF Fan, Fuhan
   Chen, Min
   Li, Yuying
   Yan, Jierui
   Wang, Xiaobo
   Zhang, Yi
   Zheng, Chuan
   Zhou, Jie
   Ren, Dongsheng
   Meng, Xianli
   Hou, Ya
TI Association between systemic immune-inflammation indexes and Nuodikang
   capsule's protection in LPS-induced acute lung injury in mice
SO PHYTOMEDICINE
LA English
DT Article
DE Nuodikang capsule; Acute lung injury; Immune-inflammation; Pulmonary
   function homeostasis; Air-blood barrier
ID PATHOGENESIS; TYROSOL; CELLS
AB Background: Acute lung injury (ALI) is a prevalent clinical syndrome characterized by respiratory distress and progressive hypoxemia, which arises from diverse intrapulmonary and extrapulmonary etiological factors. Currently, there is no definitive treatment for ALI. The Nuodikang capsule (NDK) is a traditional Tibetan medicine composed of Rhodiola crenulata (Hook. f. & Thomson) H. Ohba (R. crenulata), which is known for its remarkable therapeutic effects on lung diseases by regulating Chiba, benefiting Qi and clearing lung-heat. However, its efficacy in treating ALI and the underlying mechanisms remain unclear. Methods: This study initially employed UPLC-Q-Exactive Orbitrap/MS technology to analyze the chemical constituents of NDK. Subsequently, the protective effects and underlying mechanisms of NDK on an ALI model in C57BL/6 J mice were investigated. Following a 14-day intragastric administration of varying doses of NDK (0.14, 0.28 and 0.56 g/kg), an ALI model was constructed by noninvasive intratracheal instillation of lipopolysaccharide (LPS, 5 mg/kg). Respiratory function and the degree of lung injury in ALI mice were assessed using whole-body plethysmography (WBP). Additionally, complete blood counts in blood and bronchoalveolar lavage fluid (BALF) of mice were analysed by hematology analyzer. The water content in the lung tissue of mice was determined by calculating the ratio of dry weight to wet weight. Pathological damage to mouse lung tissue was evaluated using hematoxylin and eosin (H&E) staining, periodic acid-Schiff (PAS) staining and immunohistochemical staining (IHC), while structural damage was evaluated via micro-computed tomography (micro-CT). Synchronously, the Luminex 200 system was employed to analyze the levels of 23 chemokines and immuneinflammatory factors in serum, BALF and lung tissue of mice. Meanwhile, flow cytometry was utilized to determine the M1/M2 macrophage ratio, as well as the levels of B lymphocytes, dendritic cells (DCs), natural killer cells (NKs), T lymphocytes and their subtypes in the blood and lung tissues of mice with ALI. Additionally, the immunoregulatory and anti-inflammatory effects of NDK were validated using Kyoto Encyclopedia of Genes , Genomes (KEGG) and Gene Set Enrichment Analysis (GSEA) in transcriptomic studies. The ultrastructural changes of blood vessels, alveoli and other lung tissue structures in ALI mice were measured by transmission electron microscopy (TEM). Finally, the gene and protein expression levels of Zonula Occludens-1 (ZO-1), Occludin (OCLN) and VE-cadherin in the lung tissues samples of ALI mice were detected by qRT-PCR, western blot (WB) and immunofluorescence. Results: Through the use of UPLC-Q-Exactive Orbitrap/MS, 95 chemical components in NDK were identified overall, which cover anti-inflammatory compounds such as salidroside, tyrosol and gallic acid. The results from WBP indicated that NDK intervention significantly ameliorated the aberrant changes in respiratory frequency (RF), minute volume (Mv), enhanced pause (Penh) , peak expiratory flow (PEF) observed in ALI mice, thereby improving their respiratory function. Furthermore, NDK was effective in reducing pulmonary water content and decreasing the levels of inflammatory cells in both the peripheral blood and BALF of ALI mice. Histological analysis via H&E &E staining revealed that NDK intervention markedly diminished inflammatory cell infiltration in lung tissue, reduced capillary congestion, and mitigated collagen fiber proliferation.
   PAS staining corroborated these findings, demonstrated that NDK effectively decreased mucus secretion in the lung tissue of ALI mice, thereby preserving normal pulmonary physiological functions. The IHC results also suggested that NDK had the effect of inhibiting the expression of alpha-SMA in lung alveolar interstitium and effectively inhibited the development of fibrosis in the later stage of ALI. Additionally, micro-CT imaging illustrated that the lung ar- chitecture of NDK-treated mice exhibited enhanced clarity and structural integrity. Marvelously, a high-dose NDK intervention (0.56 g/kg) effectively reduced the levels of chemokines and inflammatory mediators, including GM-CSF, TNF-alpha, IL-1 alpha, IL-1 beta, beta, IL-3, and KC, in the lung-tissue, serum and BALF samples of mice. Moreover, the administration of 0.56 g/kg NDK statistically plummeted the ratio of M1 macrophages in the peripheral blood and lung tissue of ALI mice, counteracted the upregulation of B lymphocytes, DCs, T lym- phocytes, NKs and Th1/2/17 cells, and increased the levels of Treg cells. The findings from KEGG and GSEA enrichment analyses further corroborated that the anti-ALI effects of NDK are associated with the modulation of immune responses and the suppression of inflammatory responses. Furthermore, TEM results demonstrated that NDK intervention substantially reduced endothelial cell swelling and the number of neutrophils in lung tissue, while improving the stability of tight junction structures. Concurrently, results from qRT-PCR, Western blot and immunofluorescence assays further substantiated that 0.56 g/kg NDK effectively maintained the structural integrity of the pulmonary air-blood barrier via increasing the expression of ZO-1, OCLN and VE-cadherin, thereby supporting its therapeutic potential in ALI. Conclusions: Our study innovatively revealed that NDK protected against ALI through a unique mechanism: beyond preserving pulmonary respiratory function and enhancing immune response, it specifically mitigated inflammatory factor-induced damage to the lung air-blood barrier. This distinct interplay of immune regulation and barrier protection, rarely reported previously, highlighted NDK as a novel therapeutic candidate and offered new insights into ALI pathogenesis.
C1 [Fan, Fuhan; Chen, Min; Yan, Jierui; Zhang, Yi] Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 611137, Peoples R China.
   [Fan, Fuhan; Hou, Ya] Hosp Chengdu Univ Tradit Chinese Med, TCM Prevent & Treatment Metab & Chron Dis Key Lab, Chengdu 610075, Peoples R China.
   [Fan, Fuhan; Wang, Xiaobo] Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Acad Interdiscipline, Chengdu 611137, Peoples R China.
   [Fan, Fuhan; Zheng, Chuan; Meng, Xianli] Hosp Chengdu Univ Tradit Chinese Med, Inst High Altitude Multimorbid, TCM Integrated High Altitude Med Ctr, Chengdu 610075, Peoples R China.
   [Li, Yuying; Zhou, Jie; Ren, Dongsheng] Tibet Rhodiola Pharmaceut Holding Co Ltd, Lasa 850000, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine; Chengdu University of Traditional
   Chinese Medicine; Chengdu University of Traditional Chinese Medicine
RP Hou, Y (corresponding author), Hosp Chengdu Univ Tradit Chinese Med, TCM Prevent & Treatment Metab & Chron Dis Key Lab, Chengdu 610075, Peoples R China.; Meng, XL (corresponding author), Hosp Chengdu Univ Tradit Chinese Med, Inst High Altitude Multimorbid, TCM Integrated High Altitude Med Ctr, Chengdu 610075, Peoples R China.; Ren, DS (corresponding author), Tibet Rhodiola Pharmaceut Holding Co Ltd, Lasa 850000, Peoples R China.
EM rendongsheng@xzyy.cn; xlm999@cdutcm.edu.cn; yahou@cdutcm.edu.cn
FU Postdoctoral Fellowship Program of CPSF [GZB20250890]; University
   (Chengdu University of TCM)-Enterprise (Tibet Rhodiola Pharmaceutical
   Holding Co. Ltd.) Cooperation Project [301024062]; Science & Technology
   Department of Sichuan Province [2024NSFSC0701]
FX This work was supported by the Postdoctoral Fellowship Program of CPSF
   (GZB20250890), the University (Chengdu University of TCM)-Enterprise
   (Tibet Rhodiola Pharmaceutical Holding Co. Ltd.) Cooperation Project
   (301024062) and the Science & Technology Department of Sichuan Province
   (2024NSFSC0701).
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NR 71
TC 4
Z9 4
U1 18
U2 29
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD NOV
PY 2025
VL 147
AR 157229
DI 10.1016/j.phymed.2025.157229
EA SEP 2025
PG 22
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA 7YS7F
UT WOS:001582830700001
PM 40946659
DA 2026-05-27
ER

EF